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[1][TOP] >UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum RepID=TOP1_DICDI Length = 893 Score = 177 bits (449), Expect = 4e-43 Identities = 83/172 (48%), Positives = 118/172 (68%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA+ L+TDHV K+ F+ NFF +F+ LL + +++ ++KCDFS I HL+ + Sbjct: 347 EEVATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTK 405 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++KA K E K+A AE +++++ A +DG +E VGN+ +EPP LFLGRG H Sbjct: 406 KEQRKARSK-----EEKDAETAEKKKIQEKHGFATIDGFKEKVGNYMIEPPGLFLGRGQH 460 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TG +K+RI P DVTLN+G IP P+PG W +I+HN+ VTWLA W++ Sbjct: 461 PKTGMLKQRIMPSDVTLNIGEGEVIPPSPIPGEKWKEIVHNNTVTWLAFWRE 512 [2][TOP] >UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO Length = 910 Score = 174 bits (440), Expect = 4e-42 Identities = 85/171 (49%), Positives = 116/171 (67%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A L TD++ K +F+ NFF D++ +L VI +LE CDFS I + E Sbjct: 401 EEVATMFAVMLDTDYMNKPRFKENFFGDWKKILGKNH---VIQNLENCDFSPIYEWHQSE 457 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK TT E+K +E + ++ ++ A VDG++E VGNFRVEPP LF GRG+HP Sbjct: 458 KEKKKQ----MTTEEKKALKEEKLKQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHP 513 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RI+P D+T+N+G +APIPECPVPG W ++ H++ VTWLA W D Sbjct: 514 KMGKLKKRIRPCDITINIGKDAPIPECPVPGERWKEVRHDNTVTWLAFWND 564 [3][TOP] >UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI Length = 857 Score = 172 bits (436), Expect = 1e-41 Identities = 84/171 (49%), Positives = 115/171 (67%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A L TD++ KEKF+ NF AD+R +L VI L+ CDF+ I ++E Sbjct: 351 EEVATMFAVMLDTDYMQKEKFKENFMADWRKILGKNH---VIQRLDDCDFTPIYEWHQEE 407 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK +T E+K +E + + ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 408 KEKKKQ----MSTEEKKTLKEEKLKLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHP 463 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+KRRI P D+T+N+G N+ IPECP+PG +W ++ H++ VTWLA W D Sbjct: 464 KMGKLKRRIHPSDITINIGKNSQIPECPIPGESWKEVKHDNTVTWLAFWND 514 [4][TOP] >UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum bicolor RepID=C5YGY1_SORBI Length = 921 Score = 169 bits (428), Expect = 1e-40 Identities = 85/172 (49%), Positives = 113/172 (65%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A TD+ K F NFF D+R +L +I E CDF+ I E HL Sbjct: 414 EEVATMFAVMKDTDYAGKPTFIDNFFTDWRKILGKNH---IIKKFELCDFTPIYEWHL-- 468 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 ++K +KK TT E+K RE + ++ ++ A+VDG +E VGNFRVEPP LF GRG+H Sbjct: 469 ---REKEKKKQMTTEEKKALREEKLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEH 525 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+KRRIQP D+T+N+G AP+PECP+PG +W +I H++ VTWLA W D Sbjct: 526 PKMGKLKRRIQPSDITINIGKGAPVPECPIPGESWKEIKHDNTVTWLAFWND 577 [5][TOP] >UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT Length = 926 Score = 169 bits (428), Expect = 1e-40 Identities = 81/171 (47%), Positives = 114/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A+ L TD++ K +F+ NFF+D++ +L I +LE CDF I + E Sbjct: 418 EEVATMFAAMLDTDYMNKPRFKENFFSDWKKILGKNH---TIQNLEDCDFGPIYEWHQQE 474 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK TT E+K +E + ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 475 KEKKKQ----MTTEEKKALKEERLQLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHP 530 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RI+P D+T+N+G +APIPECP+PG W ++ +++ VTWLA W D Sbjct: 531 KVGKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWND 581 [6][TOP] >UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis RepID=B9SSQ1_RICCO Length = 891 Score = 169 bits (427), Expect = 1e-40 Identities = 85/171 (49%), Positives = 113/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A TD++ K KF NF+ D+R LL VI LE CDF+ I E E Sbjct: 383 EEVATMFAVMKDTDYMQKPKFLENFWNDWRKLLGRNH---VIQKLEDCDFTPIYEWHERE 439 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK +T E+K +E + + ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 440 KEKKKQ----MSTEEKKAQKEEKLRQEEKYMWAIVDGVKEKVGNFRVEPPALFRGRGEHP 495 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RIQP D+T+N+G +APIPECP+PG +W ++ H++ VTWLA W D Sbjct: 496 KMGKLKKRIQPSDITINIGKDAPIPECPIPGESWKEVKHDNTVTWLAFWND 546 [7][TOP] >UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC Length = 852 Score = 168 bits (425), Expect = 2e-40 Identities = 82/171 (47%), Positives = 112/171 (65%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT YA L TD++ K +F+ NF D+R +L VI +L+ CDF+ I E Sbjct: 370 EEVATMYAVMLDTDYMSKLQFKENFMNDWRKILGKNH---VIQNLDDCDFTPIYERPSSE 426 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK +T ++ RE + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 427 KEKKKQ----MSTKRKRPLREEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHP 482 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+KRRI+P D+T+N+G APIPECP+PG W ++ H++ VTWLA W D Sbjct: 483 KMGKLKRRIRPNDITINIGKGAPIPECPIPGERWKEVRHDNTVTWLAFWND 533 [8][TOP] >UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT Length = 926 Score = 168 bits (425), Expect = 2e-40 Identities = 79/171 (46%), Positives = 114/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A L TD++ K +F+ NFF+D++ +L + +LE CDF I + E Sbjct: 418 EEVATMFAVMLDTDYMTKPRFKENFFSDWKKMLGKNH---TVQNLEDCDFGPIYEWHQQE 474 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K K+K TT E+K +E ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 475 KEKRKQ----MTTEEKKALKEERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHP 530 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RI+P D+T+N+G +APIPECP+PG W ++ +++ VTWLA W D Sbjct: 531 KMGKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWND 581 [9][TOP] >UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q84ZL5_ORYSJ Length = 916 Score = 167 bits (424), Expect = 3e-40 Identities = 83/172 (48%), Positives = 114/172 (66%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A TD+ K+ F NFF D+R +L VI E CDF+ I E HL Sbjct: 409 EEVATMFAVMKDTDYASKQTFIDNFFTDWRKILGKNH---VIKKFELCDFTPIYEWHL-- 463 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 ++K +KK T+ E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+H Sbjct: 464 ---REKEKKKQMTSEEKKALKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEH 520 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+KRRI+P D+T+N+G APIPECP+PG +W ++ H++ VTWLA W D Sbjct: 521 PKMGKLKRRIKPSDITINIGKGAPIPECPIPGESWKEVKHDNTVTWLAFWND 572 [10][TOP] >UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT Length = 927 Score = 167 bits (424), Expect = 3e-40 Identities = 81/171 (47%), Positives = 115/171 (67%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A L TD++ K +F+ NFF+D++ +L I +LE CDF I + E Sbjct: 419 EEVATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNH---TIQNLEDCDFGPIYEWHQQE 475 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK TT E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 476 KEKKKQ----MTTEEKKALKEDKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHP 531 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RI+P D+T+N+G +APIPECP+PG W ++ +++ VTWLA W D Sbjct: 532 KMGKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWID 582 [11][TOP] >UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=A2YRB7_ORYSI Length = 916 Score = 167 bits (424), Expect = 3e-40 Identities = 83/172 (48%), Positives = 114/172 (66%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A TD+ K+ F NFF D+R +L VI E CDF+ I E HL Sbjct: 409 EEVATMFAVMKDTDYASKQTFIDNFFTDWRKILGKNH---VIKKFELCDFTPIYEWHL-- 463 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 ++K +KK T+ E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+H Sbjct: 464 ---REKEKKKQMTSEEKKALKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEH 520 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+KRRI+P D+T+N+G APIPECP+PG +W ++ H++ VTWLA W D Sbjct: 521 PKMGKLKRRIKPSDITINIGKGAPIPECPIPGESWKEVKHDNTVTWLAFWND 572 [12][TOP] >UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B7ZWU7_MAIZE Length = 574 Score = 166 bits (421), Expect = 6e-40 Identities = 83/172 (48%), Positives = 112/172 (65%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A TD+ K F NFF D+R +L +I + E CDF+ I E HL Sbjct: 67 EEVATMFAVMKDTDYAAKPTFIDNFFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL-- 121 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 ++K KK TT E+K RE + ++ ++ A+VDG +E VGNFRVEPP LF GRG+H Sbjct: 122 ---REKERKKQMTTEEKKTLREDKLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEH 178 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+KRRI P D+T+N+G AP+PECP+PG +W ++ H++ VTWLA W D Sbjct: 179 PKMGKLKRRILPSDITINIGKGAPVPECPIPGESWKEVKHDNTVTWLAFWND 230 [13][TOP] >UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE Length = 904 Score = 166 bits (420), Expect = 8e-40 Identities = 83/172 (48%), Positives = 111/172 (64%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A TD+ K F NFF D+R +L +I + E CDF+ I E HL Sbjct: 397 EEVATMFAVMKDTDYAAKPTFIDNFFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL-- 451 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 ++K KK TT E+K RE ++ ++ A+VDG +E VGNFRVEPP LF GRG+H Sbjct: 452 ---REKERKKQMTTEEKKTLREDNLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEH 508 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+KRRI P D+T+N+G AP+PECP+PG +W ++ H++ VTWLA W D Sbjct: 509 PKMGKLKRRILPSDITINIGKGAPVPECPIPGESWKEVKHDNTVTWLAFWND 560 [14][TOP] >UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC Length = 894 Score = 166 bits (420), Expect = 8e-40 Identities = 82/171 (47%), Positives = 114/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A L TD++ K KF+ NF D+R +L VI +LE CDF+ I + E Sbjct: 387 EEVATMFAVMLDTDYMTKSKFKENFMDDWRKILGKNH---VIQNLEDCDFTPIYEWHQRE 443 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK T E+K +E ++ ++ A+V+G +E VGNFRVEPP+LF GRG+HP Sbjct: 444 KEKKKK----MTAEEKKVLKEERLKQEEKYMWAIVNGVKEKVGNFRVEPPSLFRGRGEHP 499 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+ I+P D+T+N+G +APIPECP+PG +W +I H++ VTWLA W D Sbjct: 500 KMGKLKKCIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAFWND 550 [15][TOP] >UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI Length = 760 Score = 166 bits (420), Expect = 8e-40 Identities = 85/179 (47%), Positives = 118/179 (65%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI 159 EEVA F+ + L+TDH F+ NFF DF+A+L ++ AK I + KCDFS + Sbjct: 172 EEVAGFFGAMLETDHAKNPTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDM 231 Query: 160 EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNL 336 AH E K + EKKA + AE+K A +AE +++ + F V L++GR+E VGNFR+EPP L Sbjct: 232 YAHFE----KMREEKKAMSAAEKK-AIKAERDKIEEPFKVCLLNGRKEQVGNFRIEPPGL 286 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG HP TGK+KRR+ PE +T+N+G P+PE P GH WG++ H++ V WLA W + Sbjct: 287 FRGRGAHPKTGKLKRRVMPEQITINIGKGVPVPE-PPAGHKWGEVRHDNSVAWLAMWHE 344 [16][TOP] >UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR Length = 877 Score = 166 bits (419), Expect = 1e-39 Identities = 82/171 (47%), Positives = 113/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A TD+V K +FR NF+ D+R LL VI L+ CDF+ I + E Sbjct: 370 EEVATMFAVMKDTDYVQKPQFRQNFWNDWRKLLGKNH---VIQKLDDCDFNPIYEWHQQE 426 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK +T E+K +E + ++ ++ A+V+G +E VGNFRVEPP LF GRG+HP Sbjct: 427 KEKKKQ----MSTEEKKVLKEEKLKQEEKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHP 482 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K RI+P D+T+N+G +APIPECP+PG W ++ H++ VTWLA W D Sbjct: 483 KMGKLKSRIRPSDITINIGKDAPIPECPIPGERWKEVKHDNTVTWLAFWND 533 [17][TOP] >UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJG7_9ALVE Length = 551 Score = 165 bits (417), Expect = 2e-39 Identities = 86/171 (50%), Positives = 113/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ Sbjct: 131 EEVATFFAQTLGTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD-- 187 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+ KKA+T E++ +EA+ +T +VD E VGNFRVEPPNLF GRGDHP Sbjct: 188 --KRSEAKKARTKEEKEAEKEAKRLNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHP 245 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+ I PEDVT+N +AP P CPVPGH + ++H+ VTWLA + D Sbjct: 246 KMGKLKQYILPEDVTVNCAADAPAPRCPVPGHAYKDVVHDPAVTWLAWFTD 296 [18][TOP] >UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5L755_9ALVE Length = 647 Score = 165 bits (417), Expect = 2e-39 Identities = 86/171 (50%), Positives = 113/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ Sbjct: 131 EEVATFFAQTLGTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD-- 187 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+ KKA+T E++ +EA+ +T +VD E VGNFRVEPPNLF GRGDHP Sbjct: 188 --KRSEAKKARTKEEKEAEKEAKRLNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHP 245 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+ I PEDVT+N +AP P CPVPGH + ++H+ VTWLA + D Sbjct: 246 KMGKLKQYILPEDVTVNCAADAPAPRCPVPGHAYKDVVHDPAVTWLAWFTD 296 [19][TOP] >UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe RepID=TOP1_SCHPO Length = 814 Score = 164 bits (416), Expect = 2e-39 Identities = 75/171 (43%), Positives = 109/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FYA+ L+TDH F+ NFF DF + + F I KCDF+++ H E Sbjct: 232 EEVAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFE-- 289 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 +K+ EKK+ ++K ++ + E ++ ++DGR+E VGNFR+EPP LF GRG HP Sbjct: 290 --QKREEKKSMPKEQKKAIKQKKDEEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHP 347 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 TG +KRR+ PE +T+N+G P+PE P+PGH W ++ H++ VTWLA W + Sbjct: 348 KTGSLKRRVYPEQITINIGEGVPVPE-PLPGHQWAEVKHDNTVTWLATWHE 397 [20][TOP] >UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST Length = 780 Score = 163 bits (413), Expect = 5e-39 Identities = 86/173 (49%), Positives = 114/173 (65%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA FY + L+TDH F+ NFF DF ++ +T + V I EK DFS+I AH E Sbjct: 194 EEVAGFYGAMLETDHAKNPVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE- 252 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 354 K E+K T ++K+A + E ER+ + + L +G +E VGNFRVEPP LF GRG Sbjct: 253 ----KLREEKKLLTKDQKKAMKEEKERIEEPYKTCLFNGHKELVGNFRVEPPGLFRGRGA 308 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PE VTLN+G A IPE P PGH+WG+I +++ VTWLA W++ Sbjct: 309 HPRTGKLKRRVYPEMVTLNIGAGAKIPEAP-PGHSWGEIKNDNTVTWLAMWRE 360 [21][TOP] >UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q8RX06_ARATH Length = 514 Score = 162 bits (411), Expect = 9e-39 Identities = 82/172 (47%), Positives = 114/172 (66%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A +TD+ K +FR NF+ D+R LL VI L+ CDF+ I E HLE+ Sbjct: 4 EEVATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE 60 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K +KK +T E+K +E + ++ ++ A+VDG +E +GNFRVEPP LF GRG+H Sbjct: 61 -----KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEH 115 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D Sbjct: 116 PKMGKLKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWAD 167 [22][TOP] >UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa RepID=B9I1A0_POPTR Length = 860 Score = 162 bits (411), Expect = 9e-39 Identities = 81/171 (47%), Positives = 111/171 (64%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A T++V K +F NF+ D+R LL VI LE CDF+ I + E Sbjct: 353 EEVATMFAVMKDTEYVQKPQFLQNFWNDWRTLLGKNH---VIQKLEACDFNPIYEWHQKE 409 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK +T E+K RE + ++ + A+V+G +E VGNFRVEPP LF GRG+HP Sbjct: 410 KEKKKQ----MSTEEKKAVREEKLKQEEMYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHP 465 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K RI+P D+T+N+G +APIP+CP+PG W ++ H++ VTWLA W D Sbjct: 466 KMGKLKSRIRPSDITINIGKDAPIPKCPIPGERWKEVKHDNTVTWLAFWND 516 [23][TOP] >UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE Length = 2575 Score = 162 bits (411), Expect = 9e-39 Identities = 79/171 (46%), Positives = 113/171 (66%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A FYA L D+V K+ F NF D+RA + + K +T ++KCDFS I +H + Sbjct: 1906 EEIAGFYAMMLTRDYVHKDIFNENFMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQR 1964 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 +KA K E+++ +EAEA+ ++ AL+DGR+ T+GNFR+EPP LF GRG+HP Sbjct: 1965 AEARKAASKE----EKEKRKEAEAKLKEEYGFALMDGRKVTIGNFRIEPPGLFQGRGEHP 2020 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K R+ PEDV +N+GP +PE P GH W ++ H++ VTWLAGWK+ Sbjct: 2021 KMGKLKLRVMPEDVIINVGPKDKVPE-PPAGHKWKEVKHDNTVTWLAGWKE 2070 [24][TOP] >UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XZS7_CLAL4 Length = 764 Score = 162 bits (411), Expect = 9e-39 Identities = 82/172 (47%), Positives = 107/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+A L+TDH F+ NFF DF +L + V IT +KCDFS++ AH Sbjct: 180 EEVAGFFAEMLETDHAKNPVFQKNFFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF-- 237 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K + EKK + AE+ ++ + L++GR E VGNF+VEPP+LF GRG H Sbjct: 238 --VKVREEKKNMSKAEKLRLKQEREALEEPYRTCLLNGRRENVGNFKVEPPSLFRGRGAH 295 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+K+R+ PED+TLNLG APIP P GH WG+I H+ V WLA WK+ Sbjct: 296 PKTGKLKKRVYPEDITLNLGIEAPIPPAP-EGHKWGEIRHDKSVVWLAMWKE 346 [25][TOP] >UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH Length = 916 Score = 162 bits (411), Expect = 9e-39 Identities = 82/172 (47%), Positives = 114/172 (66%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A +TD+ K +FR NF+ D+R LL VI L+ CDF+ I E HLE+ Sbjct: 406 EEVATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE 462 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K +KK +T E+K +E + ++ ++ A+VDG +E +GNFRVEPP LF GRG+H Sbjct: 463 -----KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEH 517 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D Sbjct: 518 PKMGKLKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWAD 569 [26][TOP] >UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59XR0_CANAL Length = 780 Score = 162 bits (410), Expect = 1e-38 Identities = 85/172 (49%), Positives = 110/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 196 EEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE- 254 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K + EKKA + E+K +E + + + ++GR+E VGNFR+EPP LF GRG H Sbjct: 255 ---KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAH 311 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+KRR+ PE VTLNLG +A IPE P GH WG+I H++ VTWLA WK+ Sbjct: 312 PKTGKLKRRVVPEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKE 362 [27][TOP] >UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59WV6_CANAL Length = 780 Score = 162 bits (410), Expect = 1e-38 Identities = 85/172 (49%), Positives = 110/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 196 EEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE- 254 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K + EKKA + E+K +E + + + ++GR+E VGNFR+EPP LF GRG H Sbjct: 255 ---KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAH 311 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+KRR+ PE VTLNLG +A IPE P GH WG+I H++ VTWLA WK+ Sbjct: 312 PKTGKLKRRVVPEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKE 362 [28][TOP] >UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T3W2_PHYPA Length = 632 Score = 161 bits (408), Expect = 2e-38 Identities = 80/171 (46%), Positives = 110/171 (64%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+AT +A L+TD+ KE+F NF+ D++ L VI E CDF+ I D Sbjct: 126 EEIATMFAVMLETDYAKKERFIKNFWDDWKPYLGKNH---VIKKFELCDFTPIF----DW 178 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 A++K KK+ +T E+K +E + ++ A+VDG +E VGNFRVEPP LF GRGDHP Sbjct: 179 HAREKERKKSMSTEEKKRLKEEKLAVEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHP 238 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K RI P D+ +N+G +A +PECP+PG W +I H++ VTWLA WKD Sbjct: 239 KMGKLKTRILPHDIVINIGKDAAVPECPIPGQRWKEIRHDNTVTWLAYWKD 289 [29][TOP] >UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36 RepID=B9WIH6_CANDC Length = 777 Score = 161 bits (408), Expect = 2e-38 Identities = 85/172 (49%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 193 EEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE- 251 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K + EKKA + E+K +E + + F ++GR+E VGNFR+EPP LF GRG H Sbjct: 252 ---KLREEKKAMSKEEKKRIKEEKEKEEEPFKTCYLNGRKELVGNFRIEPPGLFRGRGAH 308 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+KRR+ PE VTLNL +A IPE P GH WG+I H++ VTWLA WK+ Sbjct: 309 PKTGKLKRRVAPEQVTLNLSKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKE 359 [30][TOP] >UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera RepID=UPI000198447D Length = 883 Score = 161 bits (407), Expect = 3e-38 Identities = 81/171 (47%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A TD+ K +F NF D+R L VI E CDF+ I E E Sbjct: 376 EEVATMFAVMKDTDYATKPRFIENFMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKE 432 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK TT E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 433 KEKKKQ----MTTEEKKALKEEKLKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHP 488 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RI P D+T+N+G AP+PECP+PG W ++ H++ VTWLA W D Sbjct: 489 KMGKLKKRICPSDITINIGKEAPVPECPIPGERWKEVRHDNTVTWLAFWND 539 [31][TOP] >UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri RepID=Q00XV7_OSTTA Length = 783 Score = 161 bits (407), Expect = 3e-38 Identities = 79/171 (46%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A F+A TD+ K F NF F+ LA+ A IT KCDF+++ H Sbjct: 272 EEIAGFFAVMKDTDYAQKAVFVKNFMDGFKEALANGPHA-FITDFRKCDFTKMYNHF--- 327 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 AK + EKK T+ E+K + + + +T A +DGR E VGNFR+EPP LF GRG+HP Sbjct: 328 -AKIREEKKQMTSEEKKRIKAEKDKAEEMYTWATIDGRREKVGNFRIEPPGLFRGRGEHP 386 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+KRR+ PED+T+N+G +A +P P PGH+W +IHN TWLAGW D Sbjct: 387 KMGKIKRRVMPEDITINIGKDARVPP-PPPGHSWKAVIHNDTATWLAGWND 436 [32][TOP] >UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7PX10_VITVI Length = 789 Score = 161 bits (407), Expect = 3e-38 Identities = 81/171 (47%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A TD+ K +F NF D+R L VI E CDF+ I E E Sbjct: 282 EEVATMFAVMKDTDYATKPRFIENFMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKE 338 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK TT E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 339 KEKKKQ----MTTEEKKALKEEKLKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHP 394 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+RI P D+T+N+G AP+PECP+PG W ++ H++ VTWLA W D Sbjct: 395 KMGKLKKRICPSDITINIGKEAPVPECPIPGERWKEVRHDNTVTWLAFWND 445 [33][TOP] >UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum RepID=Q94705_PHYPO Length = 1015 Score = 161 bits (407), Expect = 3e-38 Identities = 81/172 (47%), Positives = 113/172 (65%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L+TD+ KE F +NF++DFR L + KVI K DF+ I +L ++ Sbjct: 447 EEVATFYAKYLETDYPKKENFNTNFWSDFRTYLTPEQ-KKVIKDFSKADFTHIHKYLVEQ 505 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K E KA TAE K+A +AE E++ Q + A+++G + + N+ +E P LFLGRG H Sbjct: 506 K-----ELKANRTAEEKKAEKAEKEKLLQKYGFAMINGHRQRISNWAIERPGLFLGRGAH 560 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TG VK+RI+ ED+T+N+G P+PE P PGH W K++H+ V WLA WK+ Sbjct: 561 PKTGLVKKRIEAEDITINIGKGVPVPE-PPPGHKWCKVVHDDKVAWLAMWKE 611 [34][TOP] >UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH Length = 917 Score = 159 bits (403), Expect = 8e-38 Identities = 81/172 (47%), Positives = 110/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A +T++ K KFR NF+ D+R LL K SL+ CDF+ I E Sbjct: 404 EEVATMFAVMRETEYYKKPKFRENFWNDWRKLLGKNHMIK---SLDDCDFTPIYEWYMQE 460 Query: 181 KAKKKAEKKAQTTAERKE-AREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K KK Q TAE K +E + ++ ++ A++DG E +GNFRVEPP LF GRG+H Sbjct: 461 KETKK-----QMTAEEKRIVKEEKLKQEEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEH 515 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+K+RI+P D+T+N+G APIPECP+PG W ++ H++ VTWLA W D Sbjct: 516 PKMGKLKKRIRPCDITINIGKEAPIPECPIPGERWKEVKHDNTVTWLAFWSD 567 [35][TOP] >UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus RepID=A5E508_LODEL Length = 849 Score = 159 bits (403), Expect = 8e-38 Identities = 82/172 (47%), Positives = 111/172 (64%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+ + ++TDH F+ NFF DF+ +L ++ V I EK DFS+I A+ E Sbjct: 265 EEVAGFFGAMVETDHAKNPVFQKNFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE- 323 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 KK+ EKKA + E+K +E + F L++GR+E VGNFR+EPP LF GRG H Sbjct: 324 ---KKREEKKAMSREEKKRLKEEKDRIEEPFKTCLLNGRKELVGNFRIEPPGLFRGRGAH 380 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+KRR++PE VTLNL IPE P GH+W ++ H++ VTWLA WK+ Sbjct: 381 PKTGKLKRRVRPEQVTLNLSKGVKIPE-PPAGHHWAEVRHDNEVTWLAMWKE 431 [36][TOP] >UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG Length = 763 Score = 159 bits (402), Expect = 1e-37 Identities = 79/172 (45%), Positives = 114/172 (66%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+ + L T+H F++NFF+DF+ ++ + A V I S +KCDFS+I H E Sbjct: 178 EEVACFFGAMLNTEHAQNPAFQNNFFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYET 237 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +K+ KK+ T A+++E + + + ++ L++GR E VGNFR+EPP LF GRG H Sbjct: 238 QKSLKKS----LTAAQKREIKSEKDKFEEKYKYCLLNGRRERVGNFRIEPPGLFRGRGSH 293 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TG+VK+RI PEDV+LNL +APIP P GH W +I H++ V WLA W++ Sbjct: 294 PKTGRVKKRIYPEDVSLNLSEDAPIPP-PPEGHQWKEIKHDNTVAWLATWRE 344 [37][TOP] >UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL Length = 778 Score = 159 bits (402), Expect = 1e-37 Identities = 84/172 (48%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 194 EEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE- 252 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K + EKKA + E+K +E + + + ++GR+E VGNFR+EPP LF GRG H Sbjct: 253 ---KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAH 309 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+KRR+ E VTLNLG +A IPE P GH WG+I H++ VTWLA WK+ Sbjct: 310 PKTGKLKRRVVSEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKE 360 [38][TOP] >UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MGX0_9CHLO Length = 685 Score = 158 bits (400), Expect = 2e-37 Identities = 76/172 (44%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLED 177 EE A F+A TD+ K+ F NF+ F+ +L A I +KCDF+++ HL Sbjct: 199 EEAANFFAVMKDTDYAQKDVFVKNFWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHL-- 256 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K++ +KKA + ++K+A+ A+ ++ A++DGR E VGNFRVEPP LF GRG+H Sbjct: 257 ---KEREKKKAISNEDKKKAKAAKDAEEEKYNWAVIDGRRERVGNFRVEPPGLFRGRGEH 313 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G++K+RI PED+T+N+G P P+ P PGH W +IHN VTWL GW D Sbjct: 314 PKMGRIKKRIMPEDITINIGKGVPAPD-PGPGHKWKDVIHNDTVTWLCGWND 364 [39][TOP] >UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FNH4_CANGA Length = 744 Score = 157 bits (397), Expect = 4e-37 Identities = 82/174 (47%), Positives = 112/174 (64%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHL 171 EEVA F+A+ L TDH F+ NFF DF +L + T+ IT +KCDFS++ + Sbjct: 157 EEVAGFFANLLHTDHAKNPVFQKNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYF 216 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 E KK EK+ + E+K+ + + + +F +DGR+E VGNFRVEPP+LF GRG Sbjct: 217 E----LKKEEKRNMSREEKKQIKLEKDKFEEKFKFCELDGRKEQVGNFRVEPPDLFRGRG 272 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PED+ LNL +APIP P GH+WG+I H++ V WLA WK+ Sbjct: 273 AHPKTGKLKRRVYPEDIILNLSKDAPIPPAP-QGHHWGEIRHDNTVQWLAMWKE 325 [40][TOP] >UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IDM1_CHLRE Length = 586 Score = 157 bits (396), Expect = 5e-37 Identities = 78/172 (45%), Positives = 110/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A +TD++ K+ F NF+ F+ +L VI L+KCDF+ I + H+ Sbjct: 66 EEVATMFAVMKETDYMNKKVFLDNFWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQ 122 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +AKK K+ E+ ++ + E+ ++ VA VDGR E VGNFRVEPP LF GRG+H Sbjct: 123 REAKKGISKE-----EKDRIKKEKDEKEAKYKVAYVDGRPEPVGNFRVEPPGLFRGRGEH 177 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+K+R+ P D+T+N+G N P+PE P PG W ++ H+ VTWLA WKD Sbjct: 178 PKMGKIKKRVYPRDITINIGENEPVPEHPYPGQTWKEVKHDHTVTWLAYWKD 229 [41][TOP] >UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N6Y9_COPC7 Length = 863 Score = 157 bits (396), Expect = 5e-37 Identities = 78/173 (45%), Positives = 109/173 (63%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLE 174 EEVA FY + L+TDH F NFF DF+ +L + IT+ E CDF + + E Sbjct: 295 EEVAGFYGALLETDHAKDATFNKNFFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFE 354 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 354 EKAK+KA T E+K A++ + E ++ ++DGR+E VGNFR+EPP LF GRG+ Sbjct: 355 AEKAKRKA----MTNEEKKAAKKKKDELEEKYKTCVMDGRKEKVGNFRIEPPGLFRGRGE 410 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP G +K+R+ PED+T+N+G A IP +PG W K+IH++ VTWLA W + Sbjct: 411 HPKKGSLKKRVYPEDITINIGKEAKIPVPNIPG-KWKKVIHDNTVTWLATWTE 462 [42][TOP] >UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404 RepID=C5M985_CANTT Length = 777 Score = 156 bits (394), Expect = 9e-37 Identities = 82/172 (47%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA FY + L+TDH F+ NFF DF +L + V I EK DFS++ A+ E Sbjct: 193 EEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKEFEKMDFSKMYAYYEQ 252 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 ++ EKKA + E+K +E + + ++GR+E VGNFR+EPP LF GRG H Sbjct: 253 QRE----EKKALSRDEKKRLKEERDKFEEPYKTCYLNGRKELVGNFRIEPPGLFRGRGAH 308 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+KRR+ PE VTLNLG +A +PE P GH WG+I H++ VTWLA WK+ Sbjct: 309 PKTGKLKRRVAPEQVTLNLGKDAKVPE-PPAGHQWGEIRHDNEVTWLAMWKE 359 [43][TOP] >UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera RepID=UPI0000DB758E Length = 973 Score = 155 bits (391), Expect = 2e-36 Identities = 72/171 (42%), Positives = 110/171 (64%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L D+ K F SNFF D+R ++ +++ K++ L KC+F I A+ Sbjct: 480 EEVATFYARMLDHDYTTKPAFNSNFFHDWREVMTESERTKIV-DLSKCNFKEIHAYF--- 535 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 +K E+KA T E+++ +E E +++ ++DG +E +GNF++EPP LF GRG+HP Sbjct: 536 -IQKSEERKAMTKEEKQKIKEKNEEIQKEYGYCIIDGHKEKIGNFKIEPPGLFRGRGEHP 594 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+R+ PED+ +N ++ IP+ P PGH W +I H+ VTWLA W + Sbjct: 595 KMGKLKKRVMPEDILINCSKDSNIPK-PPPGHKWKEIRHDPNVTWLASWTE 644 [44][TOP] >UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio RepID=Q6T721_DANRE Length = 600 Score = 154 bits (388), Expect = 4e-36 Identities = 77/170 (45%), Positives = 109/170 (64%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ATFYA L ++ KE F+ NFF D+R + + K+IT+L KCDF+ I + + Sbjct: 90 EEIATFYAKMLDHEYTTKEVFQKNFFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE- 147 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 KAE+K T E K+ + EA R+ +F L+DG E +GNF++EPP LF GRG+H Sbjct: 148 ----KAEEKKNMTKEEKQVLKDEAARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEH 203 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G++K+RIQPEDV +N ++ IPE P GH W ++ H++ VTWLA W Sbjct: 204 PKMGRLKKRIQPEDVAINCSKDSKIPE-PPAGHKWKRVQHDNTVTWLASW 252 [45][TOP] >UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans RepID=Q5KB99_CRYNE Length = 881 Score = 154 bits (388), Expect = 4e-36 Identities = 83/174 (47%), Positives = 110/174 (63%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLE 174 EEVA F+ + L+TD+ KFR NFF DF+A++ K + LEKCDF + + E Sbjct: 296 EEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFE 355 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRG 351 EK KKKA T E K+A +AE +++ + A VDGR+E VGNFR EPP LF GRG Sbjct: 356 KEKEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRG 410 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +HP G VK R++PED+ +N+G APIP +PG W I H++ VTWLA WK+ Sbjct: 411 EHPKKGTVKNRLRPEDIIINIGKEAPIPVPNIPG-QWKGIQHDNTVTWLAHWKE 463 [46][TOP] >UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans RepID=O59891_CRYNE Length = 844 Score = 154 bits (388), Expect = 4e-36 Identities = 83/174 (47%), Positives = 110/174 (63%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLE 174 EEVA F+ + L+TD+ KFR NFF DF+A++ K + LEKCDF + + E Sbjct: 259 EEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFE 318 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRG 351 EK KKKA T E K+A +AE +++ + A VDGR+E VGNFR EPP LF GRG Sbjct: 319 KEKEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRG 373 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +HP G VK R++PED+ +N+G APIP +PG W I H++ VTWLA WK+ Sbjct: 374 EHPKKGTVKNRLRPEDIIINIGKEAPIPVPNIPG-QWKGIQHDNTVTWLAHWKE 426 [47][TOP] >UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TJW1_VANPO Length = 799 Score = 154 bits (388), Expect = 4e-36 Identities = 80/174 (45%), Positives = 108/174 (62%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEK---CDFSRIEAHL 171 EEVA F+A+ L TDH F+ NFF DF+ +L + LEK CDFS++ + Sbjct: 212 EEVAGFFAALLHTDHAKNTVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYF 271 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 E ++ ++K + E+K+ R + E+ F +DGR E VGNFRVEPP+LF GRG Sbjct: 272 EIQRE----QRKKLSPQEKKQLRLEKEEQEEPFKFCELDGRREQVGNFRVEPPDLFRGRG 327 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PED+ LNL NAPIP P GH WG+I H++ V WLA W++ Sbjct: 328 AHPKTGKLKRRVYPEDIVLNLDRNAPIPAVP-EGHKWGEIKHDNTVQWLAMWRE 380 [48][TOP] >UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC 6260 RepID=UPI000151AE34 Length = 754 Score = 153 bits (386), Expect = 7e-36 Identities = 76/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+A+ L+TDH F+ NF+ DF ++ ++ A V + K DF+++ AH E Sbjct: 170 EEVAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE- 228 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K +KK + E+K +EA+ + + L++GR+E VGNFRVEPP LF GRG H Sbjct: 229 ---MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAH 285 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+K+R+ PED+TLNL +PE P GH WG++ H++ V WLA WK+ Sbjct: 286 PKTGKLKKRVYPEDITLNLSKECKVPE-PPAGHKWGEVRHDNTVAWLAMWKE 336 [49][TOP] >UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP RepID=B2WCA4_PYRTR Length = 905 Score = 153 bits (386), Expect = 7e-36 Identities = 85/179 (47%), Positives = 107/179 (59%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVATFY S L + H V F NFF DF A+L T K I EKCDF Sbjct: 312 EEVATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKP 371 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E+AKKKA A+ A + E AEA+ + L DGR++ VGNFRVEPP L Sbjct: 372 IFEWFDAERAKKKALSAAEKKALKAEKEAAEAD----YMYCLWDGRKQKVGNFRVEPPGL 427 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK+R+ PE +T+N+G NA +PE P GH W +I H+ TWLA W++ Sbjct: 428 FRGRGEHPKTGRVKKRVMPEQITINIGENAKVPE-PPAGHRWKEIKHDHEGTWLAMWQE 485 [50][TOP] >UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii RepID=A5DLX4_PICGU Length = 754 Score = 153 bits (386), Expect = 7e-36 Identities = 76/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+A+ L+TDH F+ NF+ DF ++ ++ A V + K DF+++ AH E Sbjct: 170 EEVAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE- 228 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K +KK + E+K +EA+ + + L++GR+E VGNFRVEPP LF GRG H Sbjct: 229 ---MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAH 285 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+K+R+ PED+TLNL +PE P GH WG++ H++ V WLA WK+ Sbjct: 286 PKTGKLKKRVYPEDITLNLSKECKVPE-PPAGHKWGEVRHDNTVAWLAMWKE 336 [51][TOP] >UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299 RepID=C1FD86_9CHLO Length = 635 Score = 152 bits (385), Expect = 1e-35 Identities = 80/174 (45%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A TD+ K+ F NFF F+ L I +KCDF++I E Sbjct: 147 EEVATFFAVMKDTDYAQKDIFVKNFFDGFKKTLRGGPHG-FIKDFKKCDFTKIYMWNLQE 205 Query: 181 KAKKK---AEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + +KK AE+K + AE+ A E ++ A +DGR E VGN++VEPP LF GRG Sbjct: 206 RERKKSVSAEEKRKVKAEQAAAEE-------KYCWATIDGRRERVGNYKVEPPGLFRGRG 258 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +HP G+VK+RI PED+ +N+G A +PE P+PGH W +IIHN+ VTWL GW D Sbjct: 259 EHPKMGRVKKRIMPEDIIINIGKGAKVPE-PLPGHKWKQIIHNNTVTWLCGWND 311 [52][TOP] >UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E5D8 Length = 961 Score = 152 bits (384), Expect = 1e-35 Identities = 74/171 (43%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L D+ KEKF +NFF D+R ++ D K KVIT L KC+F + + ++ Sbjct: 458 EEVATFYAKMLTHDYTTKEKFNTNFFNDWRKVMTD-KERKVITDLSKCNFKPMALYFQE- 515 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K E+KA + E+K ++ +++ +DG +E +GNFR+EPP LF GRG+HP Sbjct: 516 ---KSEERKAMSKEEKKVIKDQNDAIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHP 572 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+R+ PEDV +N ++ IP+ P GH W K+ H+ VTWLA W + Sbjct: 573 KMGMLKKRVLPEDVIINCSKDSKIPK-PPDGHKWKKVQHDPSVTWLASWTE 622 [53][TOP] >UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FVE9_CANGA Length = 717 Score = 152 bits (384), Expect = 1e-35 Identities = 81/174 (46%), Positives = 108/174 (62%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHL 171 EEVA F+A L+T H F+ NFF DF+ +L D T+ I S ++ DFS + Sbjct: 130 EEVAGFFAHLLETPHAQNPVFQKNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----M 185 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 D + K EKK+ T ++KE R + ++ +DGR E VGNF+VEPP+LF GRG Sbjct: 186 HDYFVQLKEEKKSMTAMQKKEIRLEREKFEEKYKFCELDGRREQVGNFKVEPPDLFRGRG 245 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRRI+PED+ LNLG APIP P GH WG+I H++ V WLA W++ Sbjct: 246 AHPKTGKLKRRIRPEDIVLNLGEGAPIPP-PPSGHQWGEIRHDNTVQWLAMWRE 298 [54][TOP] >UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JVY3_SCHJY Length = 654 Score = 152 bits (384), Expect = 1e-35 Identities = 76/173 (43%), Positives = 105/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLE 174 EEVA F+ + L++DH F+ NFF DF+A+ A K A + CDF + + E Sbjct: 277 EEVAGFFGALLESDHAQNPTFQKNFFRDFQAVCKEAGMKSADIPKEFNSCDFRPMFEYFE 336 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 354 K KK K E+KE ++ + E +F L+DGR+E VGNFR+EPP LF GRG Sbjct: 337 SLKEAKKNMSKE----EKKELKKKKEEEEEKFKWCLLDGRKEKVGNFRIEPPGLFRGRGS 392 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TG +KRR+ PE +T+N+G A +PE P+PGH W ++ H+ VTWLA W + Sbjct: 393 HPKTGTLKRRVYPEQITINIGKGAKVPE-PLPGHKWAEVRHDDQVTWLAMWHE 444 [55][TOP] >UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia vitripennis RepID=UPI00015B4D8F Length = 1019 Score = 151 bits (381), Expect = 3e-35 Identities = 72/171 (42%), Positives = 110/171 (64%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L+ D+ K+ F NFF D+R ++ +++ AK IT L+KC+F+ + + Sbjct: 510 EEVATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAK-ITDLKKCNFTEMHKYF--- 565 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K E+KA + E+K +E E +++ + +DG +E +GNF++EPP LF GRG+HP Sbjct: 566 -IMKSEERKAMSKEEKKAIKEKNDEIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHP 624 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GK+K+R+ PEDV +N ++ P+ P PGH W +I H+ VTWLA W + Sbjct: 625 KMGKLKKRLVPEDVLINCSKDSVHPK-PPPGHKWKEIRHDPTVTWLASWTE 674 [56][TOP] >UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA Length = 892 Score = 151 bits (381), Expect = 3e-35 Identities = 73/165 (44%), Positives = 105/165 (63%) Frame = +1 Query: 19 YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA 198 YA TD++ K++F+ NF+ D+R LL VI +L+ CDF+ I + EK KKK Sbjct: 386 YAVMRDTDYMQKDRFKENFWNDWRKLLGRNH---VIQNLKDCDFTPIYDWCQSEKEKKKQ 442 Query: 199 EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVK 378 TT E+K +E + ++ ++T A+VDG + VGNFRVEPP LF GRG+HP G++K Sbjct: 443 ----MTTEEKKALKEEKLKQEEKYTWAIVDGVKRRVGNFRVEPPGLFRGRGEHPKMGRLK 498 Query: 379 RRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +RI P D+ +N+G A +PECP+PG W I +++ VTWL W D Sbjct: 499 KRIHPSDIVINIGSEAQVPECPIPGEGWKDIRNDNTVTWLCYWSD 543 [57][TOP] >UniRef100_A9T368 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T368_PHYPA Length = 502 Score = 150 bits (380), Expect = 4e-35 Identities = 74/166 (44%), Positives = 105/166 (63%), Gaps = 1/166 (0%) Frame = +1 Query: 19 YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKK 195 +A ++TD+ KE+F NF+ D++ L VI E CDF+ I + H A++K Sbjct: 2 FAVMIETDYAKKERFVKNFWDDWKPYLGKNH---VIKKFELCDFTPIFQWH-----AREK 53 Query: 196 AEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKV 375 KK + E+K +E + ++ A+VDG +E VGNFRVEPP LF GRGDHP GK+ Sbjct: 54 ERKKNMSAEEKKRLKEEKLAAEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKMGKL 113 Query: 376 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 K RI P D+ +N+G +AP+PECP+PG W ++ H++ VTWLA WKD Sbjct: 114 KTRILPHDIVINIGKDAPVPECPIPGQKWKEVRHDNTVTWLAYWKD 159 [58][TOP] >UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes RepID=TOP1M_PANTR Length = 601 Score = 149 bits (376), Expect = 1e-34 Identities = 77/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ Sbjct: 90 EEVATFYGRMLGHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDK 148 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 A +K + E K+ + EAE++ R+F ++DG +E +GNF++EPP LF GRGDH Sbjct: 149 AAARKVLSR-----EEKQKLKEEAEKLQREFGYCILDGHQEKIGNFKIEPPGLFRGRGDH 203 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 204 PKMGMLKRRIMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTE 254 [59][TOP] >UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens RepID=TOP1M_HUMAN Length = 601 Score = 149 bits (376), Expect = 1e-34 Identities = 77/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ Sbjct: 90 EEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDK 148 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 A +K + E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDH Sbjct: 149 AAARKVLSR-----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDH 203 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 204 PKMGMLKRRITPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTE 254 [60][TOP] >UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UUB0_PHANO Length = 887 Score = 149 bits (375), Expect = 1e-34 Identities = 81/179 (45%), Positives = 105/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EE ATFY S L + H V F NFF DF A+L T K I EKCDF Sbjct: 294 EEAATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDFKP 353 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I H E ++A KKA A+ A + E AEAE + + DGR++ VGNFRVEPP L Sbjct: 354 IFEHFEADRAAKKALPAAEKKALKAEKDAAEAE----YMFCMWDGRKQKVGNFRVEPPGL 409 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG++K+R+ PE +T+N+G NA +P P GH W ++ H+ TWLA W++ Sbjct: 410 FRGRGEHPKTGRIKKRVAPEQITINIGENAKVPP-PPAGHRWKEVKHDHEGTWLAMWQE 467 [61][TOP] >UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEP3_LACTC Length = 756 Score = 148 bits (374), Expect = 2e-34 Identities = 79/175 (45%), Positives = 109/175 (62%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHL 171 EEVA F+A+ L++DH F+ NFF DF +L + K I E CDFS++ + Sbjct: 169 EEVAGFFAALLESDHAQNPVFQKNFFNDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYF 228 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGR 348 + +K +KK Q +++ K+ + E E+ + F +DGR+E VGNFR+EPP LF GR Sbjct: 229 QLQKEQKK-----QLSSQEKKKLKIEKEQFEEPFKFCFLDGRKEQVGNFRIEPPGLFRGR 283 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G HP TGK+KRR+ PEDV LNL A IP+ P GH WG+I H+S V WLA W++ Sbjct: 284 GAHPKTGKLKRRVYPEDVVLNLDKEAEIPKAP-EGHKWGEIRHDSTVQWLAMWRE 337 [62][TOP] >UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187DC43 Length = 343 Score = 147 bits (372), Expect = 3e-34 Identities = 80/169 (47%), Positives = 104/169 (61%), Gaps = 2/169 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIEAHLE 174 EEVA FYA+ ++TDH F NFF D+ +L D I T +KCDF + + E Sbjct: 18 EEVAGFYAALIETDHAQDAAFNKNFFEDWLKVLQDHPPCNGIKATDFDKCDFRPMYEYFE 77 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 354 EKAKKKA A+ +K+ EAEA+ +F +DGR+E VGNFRVEPP LF GRG+ Sbjct: 78 AEKAKKKATSAAEKKEIKKQKDEAEAKYTHRF----LDGRKEKVGNFRVEPPGLFRGRGE 133 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLA 501 HP G +K R+ PED+ LN+G +AP P +PG W I H++ VTWLA Sbjct: 134 HPKKGSLKYRVCPEDIALNIGKDAPTPIPNIPG-KWKAIQHDNTVTWLA 181 [63][TOP] >UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BE191 Length = 789 Score = 147 bits (371), Expect = 4e-34 Identities = 77/173 (44%), Positives = 106/173 (61%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+ + +TDH F+ NFF DF +L D V I + DFS++ AH E Sbjct: 205 EEVAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEM 264 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 354 + +KK K + K+A +AE ++ + + L++G +E VGNFR+EPP LF GRG Sbjct: 265 LRDQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGA 319 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PEDVTLNL IPE P GH W ++ H++ V+WLA WK+ Sbjct: 320 HPKTGKLKRRVMPEDVTLNLSEGCKIPE-PPQGHKWAEVRHDNTVSWLAMWKE 371 [64][TOP] >UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA Length = 789 Score = 147 bits (371), Expect = 4e-34 Identities = 77/173 (44%), Positives = 106/173 (61%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLED 177 EEVA F+ + +TDH F+ NFF DF +L D V I + DFS++ AH E Sbjct: 205 EEVAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEM 264 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 354 + +KK K + K+A +AE ++ + + L++G +E VGNFR+EPP LF GRG Sbjct: 265 LRDQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGA 319 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PEDVTLNL IPE P GH W ++ H++ V+WLA WK+ Sbjct: 320 HPKTGKLKRRVMPEDVTLNLSEGCKIPE-PPQGHKWAEVRHDNTVSWLAMWKE 371 [65][TOP] >UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1 Tax=Tribolium castaneum RepID=UPI00017582B6 Length = 936 Score = 146 bits (369), Expect = 7e-34 Identities = 71/172 (41%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA+FY+ L D+ KE F +NFF D+R ++++++ KVI L+KC+F + A+ D Sbjct: 427 EEVASFYSKMLDHDYTTKEVFNNNFFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMD- 484 Query: 181 KAKKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 AEK T E K+A +E ++++ +DG +E +GNF++EPP LF GRG+H Sbjct: 485 ----LAEKNRNRTKEEKQALKEKNEALIKEYGFCNIDGHKEKIGNFKIEPPGLFRGRGEH 540 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRR++ ED+ +N ++ IPE P PGH W ++ H+ VTWLA W + Sbjct: 541 PKMGMLKRRVEAEDIIINCSQDSKIPE-PPPGHKWKEVRHDDNVTWLASWTE 591 [66][TOP] >UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO Length = 1043 Score = 146 bits (369), Expect = 7e-34 Identities = 71/172 (41%), Positives = 106/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + K ++I KC+F + + + E Sbjct: 534 EEAATFYAKMLNHDYCTKDVFNNNFFKDFRKTMTP-KEKEIIKDFRKCNFQEMFEYFQAE 592 Query: 181 KAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K+KA T E K A++ E+E ++++ ++DG +E +GNFR+EPP LF GRG+H Sbjct: 593 SEKRKA-----ATKEEKLAKKVESEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEH 647 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI DV++N G N+ +P+ P PG W ++ H++ VTWLA W + Sbjct: 648 PKMGMIKRRIAARDVSINCGKNSKVPQ-PPPGERWKEVRHDNTVTWLASWTE 698 [67][TOP] >UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO Length = 732 Score = 146 bits (369), Expect = 7e-34 Identities = 75/174 (43%), Positives = 110/174 (63%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV---ITSLEKCDFSRIEAHL 171 EEVA F+A+ LQ+DH F+ NFF DF ++L A+ I KCDFS++ A++ Sbjct: 145 EEVAGFFAALLQSDHAQNPVFQKNFFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYI 204 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + ++ + K ++ ERK ++ + + V L+ GR+E V F+++PP+LF GRG Sbjct: 205 QQQRV----QMKQLSSHERKLLKQEKGQTEGPVQVLLLTGRKEQVDTFKIDPPDLFRGRG 260 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+QPEDV LNL +APIPE P GH WG+I H++ V WL W++ Sbjct: 261 AHPKTGKLKRRVQPEDVVLNLDKDAPIPE-PPAGHKWGEIRHDNTVQWLCMWRE 313 [68][TOP] >UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus RepID=UPI00017968A4 Length = 655 Score = 145 bits (367), Expect = 1e-33 Identities = 75/172 (43%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY L ++ KE F++NFF+D+R + + K+I L+KCDF+ I + D+ Sbjct: 144 EEVATFYGKMLDHEYTTKEVFQNNFFSDWRKEMTAEE-RKIIKHLDKCDFTEIHRYFVDK 202 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 A +KA + E K+ + EAE+++Q F +DG E +GNF+ EPP LF GRGDH Sbjct: 203 TAARKALSR-----EEKQKLKEEAEKLQQEFGYCTLDGHREKIGNFKTEPPGLFRGRGDH 257 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI PEDVT+N ++ IP+ P GH W ++ ++ VTWLA W + Sbjct: 258 PKMGMLKRRILPEDVTINCSRDSKIPK-PPAGHQWKEVRSDNTVTWLASWTE 308 [69][TOP] >UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA Length = 763 Score = 145 bits (367), Expect = 1e-33 Identities = 73/172 (42%), Positives = 106/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEK-FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED 177 EEVA F+ + L ++ +K F+ NFF DF+ T + E CDF+ + + E Sbjct: 179 EEVAGFFGAILSSEQYVKNPTFQKNFFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFE- 237 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 KKK EKK ++ E+K+ +E + ++ +DGR+E VGNFR+EPP LF GRGDH Sbjct: 238 ---KKKEEKKNKSKEEKKKIKEEKDALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDH 294 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P TGK+K R+ PE V +N+G ++ IP P PGHNW ++ H++ VTWLA W + Sbjct: 295 PKTGKLKTRVVPEQVIINIGKDSVIPS-PPPGHNWKEVRHDNTVTWLATWNE 345 [70][TOP] >UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=UPI0001760D92 Length = 748 Score = 145 bits (366), Expect = 2e-33 Identities = 73/172 (42%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L+ ++ E FR NFF D+R + + +K IT L+KCDF+++ + Sbjct: 237 EEVATFYAKMLEHEYTTNEIFRKNFFKDWRKEMTSEEKSK-ITELKKCDFTQMHEYF--- 292 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + E ER+ Q + L+D E +GNFR+EPP LF GRGDH Sbjct: 293 --KAQSEARKQMSKEEKQKNKEENERILQEYGFCLMDNHRERIGNFRIEPPGLFRGRGDH 350 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWL W + Sbjct: 351 PKMGKLKRRIRPEDIIINCSKDSVQPKAP-PGTRWKEVRHDNKVTWLVSWTE 401 [71][TOP] >UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi RepID=A8Q2Z1_BRUMA Length = 751 Score = 145 bits (366), Expect = 2e-33 Identities = 68/171 (39%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA+FYA L+ ++ K+ F NFF D+R ++ + K IT L KCDF + H Sbjct: 250 EEVASFYAKILEHEYTTKDIFNKNFFTDWRKVMTPAEREK-ITDLTKCDFREMHDHY--- 305 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K + E+++ + E+++ +E + E + + VA +DG ++ +GNFR+EPP+LF GRG HP Sbjct: 306 -IKLREERRSLSKEEKQKLKEIKQEEAKIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHP 364 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G++K+R+ PEDV +N ++ IP+ P GH W ++ H++ VTWL W D Sbjct: 365 KMGRLKKRVNPEDVIINCSKDSEIPK-PPEGHRWKEVRHDNTVTWLCSWTD 414 [72][TOP] >UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7Q9Y0_IXOSC Length = 499 Score = 145 bits (365), Expect = 2e-33 Identities = 70/172 (40%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FY L D+ KE F NFF D+R + K A++IT L KC+F I+ + Sbjct: 268 EEVAGFYGRMLDHDYTSKEAFNKNFFKDWRKTMTP-KEAELITDLSKCNFKEIDVYY--- 323 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K+K+E++ + E K+A +A+ E++ ++ ++DG + +GNF++EPP LF GRG+H Sbjct: 324 --KQKSEERKAMSKEEKQAIKAQNEKLLEEYGFCIIDGHRQKIGNFKIEPPGLFRGRGEH 381 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRR+ PEDV +N+G A IP P GH W ++ H++ V+WL+ W + Sbjct: 382 PKMGMLKRRVMPEDVIINIGKEAKIPP-PPEGHRWKEVRHDNTVSWLSSWTE 432 [73][TOP] >UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732 RepID=C5DTC9_ZYGRC Length = 843 Score = 145 bits (365), Expect = 2e-33 Identities = 79/175 (45%), Positives = 109/175 (62%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHL 171 EEVA F+A+ LQ+DH F+SNFF DF +L + TK I S +KCDF+++ Sbjct: 256 EEVAGFFAALLQSDHAKNTVFQSNFFNDFIEVLNENGGTKNGINIESFDKCDFTKMFEFF 315 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGR 348 E +K ++K Q + + K+ E E+ + F +DGR+E VGNF++EPP LF GR Sbjct: 316 EMQKEQRK-----QLSPQEKKQLRMEREKFEEPFKYCELDGRKEQVGNFKIEPPGLFRGR 370 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G HP TGK+KRR+ PEDV LNL +A IP P G WG+I H++ V WLA W++ Sbjct: 371 GAHPKTGKLKRRVYPEDVVLNLDKDATIPPLP-EGQKWGEIRHDNTVQWLAMWRE 424 [74][TOP] >UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN Length = 990 Score = 144 bits (364), Expect = 3e-33 Identities = 69/169 (40%), Positives = 102/169 (60%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + + + E Sbjct: 495 EEAATFYAKMLNHDYCTKDVFNTNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAE 553 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + A++ E V+++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 554 SEKRKAATKEEKLAKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 609 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G + +P P PG W ++ H++ VTWLA W Sbjct: 610 KMGMIKRRIQASDVSINCGKESHVPS-PPPGQRWKEVRHDNTVTWLASW 657 [75][TOP] >UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA Length = 909 Score = 144 bits (363), Expect = 3e-33 Identities = 74/172 (43%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEV ++ T+++ K FR N D++ +L +I +L+ CDF+ I E Sbjct: 386 EEVHMIAVMQILTEYLTKPVFRENVMNDWKIILGRNH---IIKNLDDCDFTPIY-----E 437 Query: 181 KAKKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 + K EKK Q +AE K+A +E + ++ ++ A+VDG +E VGNFRVEPP LF GR Sbjct: 438 WFRLKKEKKKQMSAEEKKAVKEEKLKQEEKYMWAVVDGVKENVGNFRVEPPGLFRGRESI 497 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+K+RI P D+T+N+G +APIPECP+PG +W ++ H++ VTWLA W D Sbjct: 498 PKMGKLKKRISPSDITINIGKDAPIPECPIPGESWKEVRHDNTVTWLAYWND 549 [76][TOP] >UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2 Length = 745 Score = 144 bits (363), Expect = 3e-33 Identities = 73/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHL 171 EEVA F+A+ L++DH F+ NFF DF +L ++ I +CDF+++ + Sbjct: 158 EEVAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYF 217 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + +K +KK T+ E+K+ R + + +DGR E VGNF+VEPP+LF GRG Sbjct: 218 Q----LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRG 273 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PED+ LNL +AP+P P GH WG+I H++ V WLA W++ Sbjct: 274 AHPKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRE 326 [77][TOP] >UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae RepID=B3LJ50_YEAS1 Length = 769 Score = 144 bits (363), Expect = 3e-33 Identities = 73/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHL 171 EEVA F+A+ L++DH F+ NFF DF +L ++ I +CDF+++ + Sbjct: 182 EEVAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYF 241 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + +K +KK T+ E+K+ R + + +DGR E VGNF+VEPP+LF GRG Sbjct: 242 Q----LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRG 297 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PED+ LNL +AP+P P GH WG+I H++ V WLA W++ Sbjct: 298 AHPKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRE 350 [78][TOP] >UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae RepID=TOP1_YEAST Length = 769 Score = 144 bits (363), Expect = 3e-33 Identities = 73/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHL 171 EEVA F+A+ L++DH F+ NFF DF +L ++ I +CDF+++ + Sbjct: 182 EEVAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYF 241 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + +K +KK T+ E+K+ R + + +DGR E VGNF+VEPP+LF GRG Sbjct: 242 Q----LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRG 297 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP TGK+KRR+ PED+ LNL +AP+P P GH WG+I H++ V WLA W++ Sbjct: 298 AHPKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRE 350 [79][TOP] >UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y3I3_PHATR Length = 594 Score = 144 bits (362), Expect = 4e-33 Identities = 78/176 (44%), Positives = 102/176 (57%), Gaps = 5/176 (2%) Frame = +1 Query: 1 EEVATFYASK-LQTDHVLKEK----FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA 165 EE ATF+A+ + H+ K F NFFADFR +L K +KCDF I Sbjct: 53 EEAATFFAAMDPEGMHLGNPKTGKIFIKNFFADFREILGKKHIVK---EFKKCDFEPIRK 109 Query: 166 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 345 HL ++K +KA T ERK +E ++ + QF ++VDG E VGNF +EPP F G Sbjct: 110 HLNEQKIIRKAI----TDEERKANKEDRSQTLHQFGFSIVDGHIERVGNFNMEPPGAFRG 165 Query: 346 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 RG+HP GK+K R+ PE V+LNL AP+P CPVPGH W + H+ WLA WK+ Sbjct: 166 RGEHPKMGKLKSRVLPEQVSLNLSECAPVPPCPVPGHAWSDVRHDPRGQWLATWKE 221 [80][TOP] >UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B1 Length = 751 Score = 143 bits (361), Expect = 6e-33 Identities = 73/171 (42%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + Sbjct: 240 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF--- 295 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A +KA T E+ + +E ++QF ++D +E + NFR+EPP LF GRGDHP Sbjct: 296 KAQTEA-RKAMTKEEKLKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHP 354 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI+PED+ +N ++ PE P PG W ++ H++ VTWL W + Sbjct: 355 KMGMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTE 404 [81][TOP] >UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B0 Length = 751 Score = 143 bits (361), Expect = 6e-33 Identities = 73/171 (42%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + Sbjct: 240 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF--- 295 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A +KA T E+ + +E ++QF ++D +E + NFR+EPP LF GRGDHP Sbjct: 296 KAQTEA-RKAMTKEEKLKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHP 354 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI+PED+ +N ++ PE P PG W ++ H++ VTWL W + Sbjct: 355 KMGMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTE 404 [82][TOP] >UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus RepID=TOP1M_RAT Length = 593 Score = 143 bits (361), Expect = 6e-33 Identities = 74/170 (43%), Positives = 104/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY L + KE FR NFF+D++ + + K+IT L+KCDFS I H + Sbjct: 83 EEVATFYGKMLHLECTTKEVFRRNFFSDWQKEMTAEE-RKLITHLDKCDFSEIHRHFME- 140 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +AE + E+K+ + EAE+++Q F ++DG E +GNF+ EPP LF GRGDH Sbjct: 141 ----RAEARRTLPREQKQKLKEEAEKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDH 196 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G +KRR+ PEDV +N ++ IPE P GH W ++ ++ V WLA W Sbjct: 197 PKMGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAW 245 [83][TOP] >UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792028 Length = 1011 Score = 143 bits (360), Expect = 8e-33 Identities = 69/169 (40%), Positives = 102/169 (60%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L+ D+ KE F NF D+R + K ++IT L C+F + + Sbjct: 238 EEVATFYAKMLEHDYTTKEVFNKNFLKDWRKTMTP-KEKELITDLSLCNFKEMNVYF--- 293 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KK E+KA + E+K+ +E +++ +DG +E +GNF++EPP LF GRG+HP Sbjct: 294 -TKKSEERKAMSKEEKKKIKEENEALQKEYGFCTIDGHKEKIGNFKIEPPGLFRGRGEHP 352 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +K+R+ PEDV +N ++ IP+ P PGH W ++ H+ VTWLA W Sbjct: 353 KMGMLKKRVVPEDVLINCSKDSNIPK-PPPGHKWKEVRHDFGVTWLASW 400 [84][TOP] >UniRef100_A4S5R8 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901 RepID=A4S5R8_OSTLU Length = 491 Score = 143 bits (360), Expect = 8e-33 Identities = 72/159 (45%), Positives = 96/159 (60%) Frame = +1 Query: 37 TDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 216 +D+ K F NF F+A L + A IT KCDF+++ H + KKK T Sbjct: 4 SDYATKPVFVKNFMDGFKAALKNGPHA-FITDFSKCDFTKMYMHFLAIREKKKE----MT 58 Query: 217 TAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPE 396 + E+K + + +T A +DGR E VGNFRVEPP LF GRG+HP GK+KRR+ PE Sbjct: 59 SEEKKRIKAQKDIDEEPYTWATIDGRREKVGNFRVEPPGLFRGRGEHPKMGKIKRRVVPE 118 Query: 397 DVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 D+T+N+G +A +PE P GH+W +IHN TWLAGW D Sbjct: 119 DITINIGKDAKVPE-PPAGHSWKAVIHNDTATWLAGWND 156 [85][TOP] >UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus RepID=UPI0000ECD01B Length = 593 Score = 142 bits (359), Expect = 1e-32 Identities = 71/172 (41%), Positives = 107/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ Sbjct: 82 EEIATFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDK 140 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +KA K E K+ + EA+++++ + ++DG E +GNF+ EPP LF GRGDH Sbjct: 141 NEARKALSK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDH 195 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +K+RI PEDV +N ++ IPE PV GH W ++ ++ VTWLA W + Sbjct: 196 PKMGMLKKRIMPEDVIINCSKDSKIPEPPV-GHKWKEVRFDNTVTWLASWTE 246 [86][TOP] >UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus RepID=Q6T722_CHICK Length = 593 Score = 142 bits (359), Expect = 1e-32 Identities = 71/172 (41%), Positives = 107/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ Sbjct: 82 EEIATFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDK 140 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +KA K E K+ + EA+++++ + ++DG E +GNF+ EPP LF GRGDH Sbjct: 141 NEARKALSK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDH 195 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +K+RI PEDV +N ++ IPE PV GH W ++ ++ VTWLA W + Sbjct: 196 PKMGMLKKRIMPEDVIINCSKDSKIPEPPV-GHKWKEVRFDNTVTWLASWTE 246 [87][TOP] >UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei RepID=Q581U8_9TRYP Length = 661 Score = 142 bits (359), Expect = 1e-32 Identities = 76/169 (44%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A + D+ E FR NFF +R +L K I LE CDFS I + E Sbjct: 109 EEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYEWHQRE 166 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+K+ +T E+KE + E + + +G++E V NFRVEPP LF GRG+HP Sbjct: 167 VEKRKS----RTREEKKELKRIADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHP 222 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 + GK+K+RI PEDV LN+G APIP+ P GH W ++H+ VTWLA W Sbjct: 223 MRGKLKKRILPEDVVLNIGKEAPIPQAPA-GHKWKGVVHDQNVTWLAMW 270 [88][TOP] >UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma brucei RepID=C9ZLY6_TRYBG Length = 696 Score = 142 bits (359), Expect = 1e-32 Identities = 76/169 (44%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A + D+ E FR NFF +R +L K I LE CDFS I + E Sbjct: 144 EEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYEWHQRE 201 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+K+ +T E+KE + E + + +G++E V NFRVEPP LF GRG+HP Sbjct: 202 VEKRKS----RTREEKKELKRIADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHP 257 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 + GK+K+RI PEDV LN+G APIP+ P GH W ++H+ VTWLA W Sbjct: 258 MRGKLKKRILPEDVVLNIGKEAPIPQAPA-GHKWKGVVHDQNVTWLAMW 305 [89][TOP] >UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5C65 Length = 755 Score = 142 bits (358), Expect = 1e-32 Identities = 71/171 (41%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + Sbjct: 244 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF--- 299 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A +KA T E+ + +E ++Q+ ++D +E + NFR+EPP LF GRGDHP Sbjct: 300 KAQSEA-RKAMTKEEKLKIKEENERLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHP 358 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI+P+D+ +N ++ PE P PG W ++ H++ VTWL W + Sbjct: 359 KMGMLKRRIRPQDIIINCSKDSKYPE-PPPGTKWKEVRHDNKVTWLVSWTE 408 [90][TOP] >UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU Length = 753 Score = 142 bits (358), Expect = 1e-32 Identities = 71/171 (41%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + Sbjct: 242 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF--- 297 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A +KA T E+ + +E ++Q+ ++D +E + NFR+EPP LF GRGDHP Sbjct: 298 KAQSEA-RKAMTKEEKLKIKEENERLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHP 356 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI+P+D+ +N ++ PE P PG W ++ H++ VTWL W + Sbjct: 357 KMGMLKRRIRPQDIIINCSKDSKYPE-PPPGTKWKEVRHDNKVTWLVSWTE 406 [91][TOP] >UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA Length = 785 Score = 142 bits (358), Expect = 1e-32 Identities = 76/174 (43%), Positives = 106/174 (60%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHL 171 EEVA F+A+ L++DHV F+ NF DF +L + A+ I K DF++I + Sbjct: 198 EEVAGFFAAILESDHVKIPTFQKNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYF 257 Query: 172 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + +K +KK + E+K+ R + E + + +DGR E VGNFR+EPP LF GRG Sbjct: 258 QVQKE----QKKQLSPQEKKQLRLEKEELEKPYKFCEIDGRVEQVGNFRIEPPGLFRGRG 313 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP GK+KRR+ PEDV LNL APIPE P GH WG+I H++ V WL+ W++ Sbjct: 314 AHPKNGKLKRRVYPEDVVLNLDKEAPIPE-PPKGHKWGEIRHDNTVQWLSMWRE 366 [92][TOP] >UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HDT9_CHAGB Length = 907 Score = 142 bits (358), Expect = 1e-32 Identities = 80/179 (44%), Positives = 106/179 (59%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVATF+ S L T +V F+ NFFADF+ +L T AK I +K DF++ Sbjct: 310 EEVATFFGSMLHSTQNVENPVFQKNFFADFKDILKKTGGAKDKQGKPVDIKEFKKLDFTK 369 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I H + +KA A+ AE+ E +AE F DGR+E VGNFRVEPP L Sbjct: 370 IFDHYKALGDARKARPAAEKKAEKAEKDKAEGH----FMFCKWDGRKEKVGNFRVEPPGL 425 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG VK+R+ PE VT+N+G +A +P P PGH W + H++ TWLA W++ Sbjct: 426 FRGRGEHPKTGTVKKRVMPEQVTINIGKDAKVP-APPPGHKWKAVQHDNKATWLAMWQE 483 [93][TOP] >UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FTA8_NANOT Length = 896 Score = 142 bits (358), Expect = 1e-32 Identities = 76/179 (42%), Positives = 108/179 (60%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEK-FRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA+ + + L + H ++ F+ NFF DF+A++ T AK + KCDF Sbjct: 303 EEVASHFGTMLNSTHNVENPVFQKNFFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVP 362 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I H E K +A+KKA T AE+K A+ + + + DGR++ VGNFRVEPP L Sbjct: 363 IFEHHE----KLRAQKKAMTAAEKKAAKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPAL 418 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++ Sbjct: 419 FRGRGEHPKTGTVKTRVQPEQITINIGKDAPVP-APPEGHRWKEVRHDQEGTWLAMWQE 476 [94][TOP] >UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC Length = 884 Score = 142 bits (358), Expect = 1e-32 Identities = 77/179 (43%), Positives = 106/179 (59%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVA F+ L T HV F+ NFF DFR +L T AK I KCDF Sbjct: 291 EEVAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQP 350 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I A+ ++++ EKKA AE+K + + + + + DGR++ VGNFRVEPP L Sbjct: 351 IFAYYDNQRQ----EKKALPPAEKKRLKAEKDAQEAPYMFCMWDGRKQKVGNFRVEPPAL 406 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++ Sbjct: 407 FRGRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHKWKEVKHDQEGTWLAMWQE 464 [95][TOP] >UniRef100_B8CC91 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8CC91_THAPS Length = 536 Score = 142 bits (357), Expect = 2e-32 Identities = 67/151 (44%), Positives = 95/151 (62%) Frame = +1 Query: 61 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 240 F NFF DFR +L +I +KCDF I+ HL ++K +KA T ERK + Sbjct: 12 FIKNFFTDFRTILGKNH---IIKDFKKCDFGPIQRHLNEQKLIRKAI----TDEERKVNK 64 Query: 241 EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 420 +++ E + +F ALVDG E VGN+ +EPP F GRG+HP GK+K+R++PE V +N+ Sbjct: 65 DSKNETLFKFGYALVDGHLEKVGNYNMEPPGAFRGRGEHPKMGKLKQRVEPEQVMINVSE 124 Query: 421 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +AP+P C VPGH WG++ H+ V WL WK+ Sbjct: 125 DAPVPMCSVPGHAWGEVRHDPTVQWLCQWKE 155 [96][TOP] >UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster RepID=Q8IR39_DROME Length = 581 Score = 142 bits (357), Expect = 2e-32 Identities = 68/169 (40%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E Sbjct: 86 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAE 144 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 145 SEKRKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 200 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W Sbjct: 201 KMGMIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASW 248 [97][TOP] >UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster RepID=Q494M1_DROME Length = 974 Score = 142 bits (357), Expect = 2e-32 Identities = 68/169 (40%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E Sbjct: 479 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAE 537 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 538 SEKRKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 593 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W Sbjct: 594 KMGMIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASW 641 [98][TOP] >UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME Length = 581 Score = 142 bits (357), Expect = 2e-32 Identities = 68/169 (40%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E Sbjct: 86 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAE 144 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 145 SEKRKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 200 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W Sbjct: 201 KMGMIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASW 248 [99][TOP] >UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=B5DMS2_DROPS Length = 1054 Score = 142 bits (357), Expect = 2e-32 Identities = 70/170 (41%), Positives = 104/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + + + E Sbjct: 545 EEAATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE 603 Query: 181 KAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +EK+ Q T E K A++ E E ++++ ++DG +E +GNFR+EPP LF GRG+H Sbjct: 604 -----SEKRKQATKEEKLAKKNENEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEH 658 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G +KRRI DV++N G + +P P PG W ++ H++ VTWLA W Sbjct: 659 PKMGMIKRRIGASDVSINCGKESKVPP-PPPGSRWKEVRHDNTVTWLASW 707 [100][TOP] >UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE Length = 1042 Score = 142 bits (357), Expect = 2e-32 Identities = 70/170 (41%), Positives = 104/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + + + E Sbjct: 533 EEAATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE 591 Query: 181 KAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +EK+ Q T E K A++ E E ++++ ++DG +E +GNFR+EPP LF GRG+H Sbjct: 592 -----SEKRKQATKEEKLAKKNENEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEH 646 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G +KRRI DV++N G + +P P PG W ++ H++ VTWLA W Sbjct: 647 PKMGMIKRRIGASDVSINCGKESKVPP-PPPGSRWKEVRHDNTVTWLASW 695 [101][TOP] >UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR Length = 881 Score = 142 bits (357), Expect = 2e-32 Identities = 78/179 (43%), Positives = 107/179 (59%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSR 156 EEVA F+ S L T HV F+ NFF DF+ +L D+K KV I KCDF Sbjct: 288 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQP 347 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I A+ + K+ EKK AE+K + + + + DGR++ VGNFRVEPP+L Sbjct: 348 IFAYYD----MKRLEKKNLPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSL 403 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++ Sbjct: 404 FRGRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQE 461 [102][TOP] >UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JVV4_UNCRE Length = 889 Score = 142 bits (357), Expect = 2e-32 Identities = 78/179 (43%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A++ T AK I +KCDF Sbjct: 314 EEVAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQP 373 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E K+ EKKA AERK + + + + DGR++ VGNFRVEPP L Sbjct: 374 IFEYYE----MKRLEKKALPAAERKRLKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPAL 429 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P PGH W ++ H+ TWLA W++ Sbjct: 430 FRGRGEHPKTGRVKTRVQPEQITINIGKGAAVPP-PPPGHKWKEVKHDQEGTWLAMWQE 487 [103][TOP] >UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8MY66_ASPFN Length = 881 Score = 142 bits (357), Expect = 2e-32 Identities = 78/179 (43%), Positives = 107/179 (59%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSR 156 EEVA F+ S L T HV F+ NFF DF+ +L D+K KV I KCDF Sbjct: 288 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQP 347 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I A+ + K+ EKK AE+K + + + + DGR++ VGNFRVEPP+L Sbjct: 348 IFAYYD----MKRLEKKNLPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSL 403 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++ Sbjct: 404 FRGRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQE 461 [104][TOP] >UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster RepID=TOP1_DROME Length = 972 Score = 142 bits (357), Expect = 2e-32 Identities = 68/169 (40%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E Sbjct: 477 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAE 535 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 536 SEKRKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 591 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W Sbjct: 592 KMGMIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASW 639 [105][TOP] >UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus RepID=TOP1M_MOUSE Length = 593 Score = 142 bits (357), Expect = 2e-32 Identities = 73/170 (42%), Positives = 104/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY L + KE FR NFF+D+R + + ++IT L+KCDF+ I H + Sbjct: 83 EEVATFYGKMLHLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE- 140 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +AE + E+K+ + EAE+++Q F ++DG E +GNF+ EPP LF GRGDH Sbjct: 141 ----RAEARRTLPREQKQKLKEEAEKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDH 196 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G +KRR+ PEDV +N ++ IPE P GH W ++ ++ V WLA W Sbjct: 197 PKMGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAW 245 [106][TOP] >UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MH68_TALSN Length = 864 Score = 141 bits (356), Expect = 2e-32 Identities = 77/179 (43%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF+A+L T AK I KCDF Sbjct: 271 EEVAGFFGSMLNSTHNVENPTFQKNFFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKP 330 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + K+ EKKA + AE+K + + + + DGR++ VGNFRVEPP L Sbjct: 331 IFEYYD----AKRLEKKAMSAAEKKALKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPGL 386 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 387 FRGRGEHPKTGKVKTRVQPEQITINIGKEAKVPP-PPEGHKWKEVRHDQEGTWLAMWQE 444 [107][TOP] >UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL Length = 886 Score = 141 bits (356), Expect = 2e-32 Identities = 77/179 (43%), Positives = 105/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L T HV F+ NFF+DF+ +L T AK I KCDF Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQS 352 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I A+ + K+ EK+ AE+K + + + L DGR++ VGNFRVEPP+L Sbjct: 353 IFAYYD----AKRIEKRNIPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPSL 408 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G AP+P P GH W ++ H+ TWLA W++ Sbjct: 409 FRGRGEHPKTGRVKARVQPEQITINIGKGAPVPP-PPEGHRWKEVKHDQEGTWLAMWQE 466 [108][TOP] >UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR Length = 767 Score = 141 bits (356), Expect = 2e-32 Identities = 66/171 (38%), Positives = 105/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + VIT+L KCDF+++ + +D+ Sbjct: 256 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQ 314 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 +K K E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 315 SEARKQMSKE----EKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 370 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 371 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 420 [109][TOP] >UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG Length = 622 Score = 141 bits (355), Expect = 3e-32 Identities = 73/175 (41%), Positives = 103/175 (58%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAH 168 EEVA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I +A Sbjct: 80 EEVALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAK 138 Query: 169 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 348 +E K K EK RK +EA + + ++ L+D E +GNF++EPP LF GR Sbjct: 139 VEARKNMSKEEKLVCNIQFRKVLKEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGR 198 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G+HP GK+K+RIQPEDV +N + IP P GH W ++ H++ VTWLA W + Sbjct: 199 GEHPKQGKLKKRIQPEDVIINCSKESRIP-VPPAGHRWKEVRHDNTVTWLASWTE 252 [110][TOP] >UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER Length = 969 Score = 141 bits (355), Expect = 3e-32 Identities = 69/169 (40%), Positives = 100/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + +K ++I KC F+ + + E Sbjct: 474 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFNEMFNFFQAE 532 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 533 SEKRKAATKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 588 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G + +P P PG W ++ H++ VTWLA W Sbjct: 589 KMGMIKRRIQASDVSINCGKESKVPS-PPPGSRWKEVRHDNTVTWLASW 636 [111][TOP] >UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6R590_AJECN Length = 651 Score = 141 bits (355), Expect = 3e-32 Identities = 77/179 (43%), Positives = 105/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + ++ AK + S EKCDF Sbjct: 316 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKP 375 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E + EKK+ +AE+K + + E + + DGR++ VGNFRVEPP L Sbjct: 376 IFEYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 431 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P PGH W +I H+ TWLA W++ Sbjct: 432 FRGRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEIKHDQEGTWLAMWQE 489 [112][TOP] >UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI0001555600 Length = 689 Score = 140 bits (354), Expect = 4e-32 Identities = 71/172 (41%), Positives = 106/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ATFY L ++ K+ F++NFF+D+R + + K I LE+CDF+ I + D+ Sbjct: 178 EEIATFYGKMLDHEYTTKDIFQNNFFSDWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDK 236 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +KA K E K+ + EAE++++ F ++DG E +GNF+ EPP LF GRGDH Sbjct: 237 NEARKALPK-----EEKQKLKEEAEKLQEEFGYCILDGHREKIGNFKTEPPGLFRGRGDH 291 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +K+RI PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 292 PKMGLLKKRIMPEDVIINCSKDSKIPE-PPSGHKWKEVRFDNTVTWLASWTE 342 [113][TOP] >UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023DEFB Length = 910 Score = 140 bits (354), Expect = 4e-32 Identities = 79/184 (42%), Positives = 109/184 (59%), Gaps = 13/184 (7%) Frame = +1 Query: 1 EEVATFYASKLQT---DHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFS 153 EEVATF+ + + H+ FR NFF DF+ + D + KV I SL+KC+F Sbjct: 307 EEVATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFD 366 Query: 154 RIEAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRV 321 +I + +E K K +++ + +K+A EA FT DGR+E VGNFRV Sbjct: 367 KINDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEAP------FTHCTWDGRKEKVGNFRV 420 Query: 322 EPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLA 501 EPP+LF GRG+HP TGKVK+R+QPE +T+N+G A IPE P GH W + H+ TWLA Sbjct: 421 EPPSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKIPE-PPKGHQWKAVQHDQKATWLA 479 Query: 502 GWKD 513 W++ Sbjct: 480 MWQE 483 [114][TOP] >UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE Length = 592 Score = 140 bits (354), Expect = 4e-32 Identities = 74/170 (43%), Positives = 105/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY L + KE FR NFF+D+R + + ++IT L+KCDF+ I H + Sbjct: 83 EEVATFYGKMLHLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE- 140 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +AE + E+K+ +E EAE+++Q F ++DG E +GNF+ EPP LF GRGDH Sbjct: 141 ----RAEARRTLPREQKQLKE-EAEKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDH 195 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G +KRR+ PEDV +N ++ IPE P GH W ++ ++ V WLA W Sbjct: 196 PKMGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAW 244 [115][TOP] >UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA Length = 580 Score = 140 bits (354), Expect = 4e-32 Identities = 69/169 (40%), Positives = 99/169 (58%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + +K ++I KC F + + E Sbjct: 85 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAE 143 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 144 SEKRKAATKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 199 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRIQ DV++N G + +P P PG W ++ H++ VTWLA W Sbjct: 200 KMGMIKRRIQASDVSINCGKESKVPS-PPPGSRWKEVRHDNTVTWLASW 247 [116][TOP] >UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI Length = 997 Score = 140 bits (354), Expect = 4e-32 Identities = 67/169 (39%), Positives = 101/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + D + ++I KC+F + + E Sbjct: 488 EEAATFYAKMLNHDYCTKDVFNTNFFKDFRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAE 546 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 ++KA K + A++ E V+++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 547 SERRKAATKDEKLAKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 602 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRI +V++N G N+ +P P PG W ++ H++ VTWLA W Sbjct: 603 KMGMIKRRIGASEVSINCGKNSKVP-TPPPGQRWKEVRHDNTVTWLASW 650 [117][TOP] >UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU Length = 909 Score = 140 bits (354), Expect = 4e-32 Identities = 79/184 (42%), Positives = 109/184 (59%), Gaps = 13/184 (7%) Frame = +1 Query: 1 EEVATFYASKLQT---DHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFS 153 EEVATF+ + + H+ FR NFF DF+ + D + KV I SL+KC+F Sbjct: 306 EEVATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFD 365 Query: 154 RIEAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRV 321 +I + +E K K +++ + +K+A EA FT DGR+E VGNFRV Sbjct: 366 KINDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEAP------FTHCTWDGRKEKVGNFRV 419 Query: 322 EPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLA 501 EPP+LF GRG+HP TGKVK+R+QPE +T+N+G A IPE P GH W + H+ TWLA Sbjct: 420 EPPSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKIPE-PPKGHQWKAVQHDQKATWLA 478 Query: 502 GWKD 513 W++ Sbjct: 479 MWQE 482 [118][TOP] >UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QNQ2_PENMQ Length = 860 Score = 140 bits (354), Expect = 4e-32 Identities = 77/179 (43%), Positives = 107/179 (59%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVA F+ + L + H V F+ NFF DF+A+L T AK I +KCDF Sbjct: 267 EEVAGFFGAMLNSTHNVENPTFQKNFFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKP 326 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E ++ +KK A+ A + E EAEA + + DGR++ VGNFRVEPP+L Sbjct: 327 IFEYYEGKRLEKKNLSAAEKKALKAERDEAEAP----YMYCIWDGRKQKVGNFRVEPPSL 382 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G +A +P P GH W ++ H+ TWLA W++ Sbjct: 383 FRGRGEHPKTGKVKTRVMPEQITINIGKDAKVPP-PPEGHKWKEVRHDQEGTWLAMWQE 440 [119][TOP] >UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YQG7_NECH7 Length = 919 Score = 140 bits (353), Expect = 5e-32 Identities = 79/181 (43%), Positives = 109/181 (60%), Gaps = 10/181 (5%) Frame = +1 Query: 1 EEVATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFS 153 EEVATF+ + + + H+ FR NFF DF+ + D KV I SL+KCDF+ Sbjct: 316 EEVATFWVAMMTPASSHHMENPVFRKNFFEDFQEYCKKYGVTDADGKKVQIKSLDKCDFT 375 Query: 154 RIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPP 330 ++ + AK + K T E KEA +A+ E + FT + DGR++ VGNFRVEPP Sbjct: 376 KLADYW---LAKAEQNKTKNMTKEEKEAAKAKKEALEAPFTHCMWDGRKQKVGNFRVEPP 432 Query: 331 NLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWK 510 +LF GRG+HP TGKVK R+ PE +T+N+G A IP+ P GH W + H+ TWLA W+ Sbjct: 433 SLFRGRGEHPKTGKVKNRVTPEQITINIGKGAKIPD-PPKGHQWKAVQHDQKATWLAMWQ 491 Query: 511 D 513 + Sbjct: 492 E 492 [120][TOP] >UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HAF8_AJECH Length = 909 Score = 140 bits (352), Expect = 6e-32 Identities = 76/179 (42%), Positives = 105/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + ++ AK I S +KCDF Sbjct: 316 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKP 375 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E + EKK+ +AE+K + + E + + DGR++ VGNFRVEPP L Sbjct: 376 IFEYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 431 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P PGH W ++ H+ TWLA W++ Sbjct: 432 FRGRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQE 489 [121][TOP] >UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR RepID=C0NC53_AJECG Length = 909 Score = 140 bits (352), Expect = 6e-32 Identities = 76/179 (42%), Positives = 105/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + ++ AK I S +KCDF Sbjct: 316 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKP 375 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E + EKK+ +AE+K + + E + + DGR++ VGNFRVEPP L Sbjct: 376 IFEYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 431 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P PGH W ++ H+ TWLA W++ Sbjct: 432 FRGRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQE 489 [122][TOP] >UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=O17966-2 Length = 734 Score = 140 bits (352), Expect = 6e-32 Identities = 70/171 (40%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A FYA L ++ KE F NF D+R ++ + + I L+KCDF I+A+ +++ Sbjct: 224 EEIAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQ 282 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + +KA K + + KE +EAE V+ + +A++DG + V NFR+EPP +F GRG HP Sbjct: 283 REIRKAMTKEEKL-KIKEEKEAE---VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHP 338 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RI PEDV +N G + IP+ P PGH W ++ H++ VTWL W + Sbjct: 339 KMGLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVRHDNTVTWLCSWTE 388 [123][TOP] >UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL Length = 806 Score = 140 bits (352), Expect = 6e-32 Identities = 70/171 (40%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A FYA L ++ KE F NF D+R ++ + + I L+KCDF I+A+ +++ Sbjct: 296 EEIAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQ 354 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + +KA K + + KE +EAE V+ + +A++DG + V NFR+EPP +F GRG HP Sbjct: 355 REIRKAMTKEEKL-KIKEEKEAE---VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHP 410 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RI PEDV +N G + IP+ P PGH W ++ H++ VTWL W + Sbjct: 411 KMGLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVRHDNTVTWLCSWTE 460 [124][TOP] >UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata RepID=UPI000194D872 Length = 775 Score = 139 bits (351), Expect = 8e-32 Identities = 69/172 (40%), Positives = 105/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ + + Sbjct: 264 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF--- 319 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + E ER+ +++ ++D +E + NF++EPP LF GRG+H Sbjct: 320 --KAQSEARKQMSKEEKQKIKEENERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNH 377 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI PED+ +N ++ IP P PGH W ++ H++ VTWL W + Sbjct: 378 PKMGMLKRRIMPEDIIINCSKDSKIP-APPPGHKWKEVRHDNKVTWLVSWTE 428 [125][TOP] >UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus caballus RepID=UPI0001797824 Length = 765 Score = 139 bits (351), Expect = 8e-32 Identities = 67/171 (39%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +ITSL KCDF+++ + Sbjct: 254 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF--- 309 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 310 KAQTEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 368 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 369 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 418 [126][TOP] >UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta RepID=UPI00006D45A8 Length = 767 Score = 139 bits (351), Expect = 8e-32 Identities = 66/171 (38%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 256 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 311 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 312 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHP 370 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 371 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 420 [127][TOP] >UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA Length = 560 Score = 139 bits (351), Expect = 8e-32 Identities = 66/171 (38%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 49 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 104 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 105 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHP 163 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 164 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 213 [128][TOP] >UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI Length = 1045 Score = 139 bits (351), Expect = 8e-32 Identities = 67/171 (39%), Positives = 100/171 (58%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + K ++I KC+F + E Sbjct: 536 EEAATFYAKMLNHDYCTKDVFNNNFFKDFRKSMTP-KEKEIIKDFRKCNFQEMHQFFLAE 594 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + A++ E ++++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 595 SEKRKAATKEEKLAKKNENEAL----IKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 650 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI DV++N G + +P+ P PG W ++ H++ VTWLA W + Sbjct: 651 KMGMIKRRIAAADVSINCGKQSKVPQ-PPPGERWKEVRHDNTVTWLASWTE 700 [129][TOP] >UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735 delta SOWgp RepID=C5P0Y8_COCP7 Length = 905 Score = 139 bits (351), Expect = 8e-32 Identities = 77/179 (43%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A++ T AK +I +KCDF Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRP 371 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E K+ EKKA AERK + + + + DGR++ VGNFRVEPP L Sbjct: 372 IFEYYE----MKREEKKALPAAERKRLKVEKEAAEAPYMYCMWDGRKQKVGNFRVEPPAL 427 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 428 FRGRGEHPKTGRVKTRVQPEQITINIGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQE 485 [130][TOP] >UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1D4R5_NEOFI Length = 886 Score = 139 bits (351), Expect = 8e-32 Identities = 78/179 (43%), Positives = 103/179 (57%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L T HV F+ NFF DF+ +L T AK I KCDF Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRP 352 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E K+ EKK AE+K + + + L DGR++ VGNFRVEPP L Sbjct: 353 IFDYYE----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPAL 408 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++ Sbjct: 409 FRGRGEHPKTGRVKARVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQE 466 [131][TOP] >UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra magnipapillata RepID=UPI000192545C Length = 726 Score = 139 bits (350), Expect = 1e-31 Identities = 72/170 (42%), Positives = 104/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L D+V K+ F NFF D+R + + +I SL+KCDF + A+ Sbjct: 203 EEVATFYAKMLDHDYVKKDIFNENFFEDWRKEMTAEE-RNIIKSLDKCDFKEMHAYF--- 258 Query: 181 KAKKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K AE+K T E K+A +EA + ++ +DG ++ VGNFR+EPP LF GRGDH Sbjct: 259 --MKCAEEKRNMTKEEKQAIKEANLKIAEKYGFCEMDGHKQKVGNFRIEPPGLFRGRGDH 316 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P GK+K+R+ ++V +N+G A +P+ P G W + H++ V+WLA W Sbjct: 317 PKQGKLKKRVSAKEVIINIGKEAKVPQ-PPEGQKWKAVQHDNTVSWLACW 365 [132][TOP] >UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus scrofa RepID=UPI00017EFDA4 Length = 748 Score = 139 bits (350), Expect = 1e-31 Identities = 66/171 (38%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 238 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 293 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 294 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHP 352 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 353 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 402 [133][TOP] >UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B1DB6 Length = 770 Score = 139 bits (350), Expect = 1e-31 Identities = 71/172 (41%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 259 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NE 312 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + E ER+ Q + ++D +E +GNFR+EPP LF GRGDH Sbjct: 313 YFKAQSEARKQMSKEEKQKIKEENERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDH 372 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W + Sbjct: 373 PKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTE 423 [134][TOP] >UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A48 Length = 632 Score = 139 bits (350), Expect = 1e-31 Identities = 73/171 (42%), Positives = 101/171 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA F+A L ++ K+ FR NFF D+R + D + +I L KCDF I A Sbjct: 120 EEVALFFAQMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---H 175 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KAK +A K T E++ +EA + V +F L+D E +GNF++EPP LF GRG+HP Sbjct: 176 KAKVEARKN-MTKEEKQALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHP 234 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RIQPED+ +N A IP P GH W ++ H++ VTWL W + Sbjct: 235 KQGMLKKRIQPEDIIINCSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTE 284 [135][TOP] >UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG Length = 783 Score = 139 bits (350), Expect = 1e-31 Identities = 71/172 (41%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 240 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NE 293 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + E ER+ Q + ++D +E +GNFR+EPP LF GRGDH Sbjct: 294 YFKAQSEARKQMSKEEKQKIKEENERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDH 353 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W + Sbjct: 354 PKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTE 404 [136][TOP] >UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE Length = 970 Score = 139 bits (350), Expect = 1e-31 Identities = 67/169 (39%), Positives = 99/169 (58%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ KE F +NFF DFR + + ++I KC F + + + E Sbjct: 475 EEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCGFQEMFNYFQAE 533 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 534 SEKRKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 589 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +KRRI DV++N G ++ +P P PG W ++ H++ VTWLA W Sbjct: 590 KMGMIKRRIHASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASW 637 [137][TOP] >UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN Length = 765 Score = 139 bits (350), Expect = 1e-31 Identities = 66/171 (38%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 254 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 309 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 310 KAQTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHP 368 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 369 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 418 [138][TOP] >UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis RepID=Q1DXZ1_COCIM Length = 905 Score = 139 bits (350), Expect = 1e-31 Identities = 77/179 (43%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A++ T AK +I +KCDF Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRP 371 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E K+ EKKA AERK + + + + DGR++ VGNFRVEPP L Sbjct: 372 IFEYYE----MKREEKKALPAAERKRLKAEKEAAEAPYMYCMWDGRKQKVGNFRVEPPAL 427 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 428 FRGRGEHPKTGRVKIRVQPEQITINIGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQE 485 [139][TOP] >UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN Length = 765 Score = 139 bits (350), Expect = 1e-31 Identities = 66/171 (38%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 254 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 309 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 310 KAQTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHP 368 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 369 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 418 [140][TOP] >UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE Length = 767 Score = 139 bits (350), Expect = 1e-31 Identities = 66/171 (38%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 256 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 311 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 312 KAQTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHP 370 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 371 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 420 [141][TOP] >UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155C8C4 Length = 781 Score = 139 bits (349), Expect = 1e-31 Identities = 66/171 (38%), Positives = 108/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + + + IT+L KCDF+ + + Sbjct: 270 EEVATFFAKMLDHEYTTKDIFRKNFFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF--- 325 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+++ +E + ++++ ++D E + NFR+EPP LF GRG+HP Sbjct: 326 KAQSEARKQ-MSKEEKQKIKEENEQLLKEYGFCVMDNHRERIANFRIEPPGLFRGRGNHP 384 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRIQPED+ +N ++ +P P PGH W ++ H++ VTWL W + Sbjct: 385 KMGMLKRRIQPEDIIINCSKDSKVPP-PPPGHRWKEVRHDNKVTWLVSWTE 434 [142][TOP] >UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum RepID=Q9Y180_LEIIN Length = 635 Score = 139 bits (349), Expect = 1e-31 Identities = 83/175 (47%), Positives = 104/175 (59%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL-- 171 EEVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL Sbjct: 81 EEVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQ 138 Query: 172 -EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 348 E + ++ K EKKA KE ++AEAE R + DGR E V NFRVEPP LF GR Sbjct: 139 REKKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGR 190 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G HPL GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+D Sbjct: 191 GKHPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRD 244 [143][TOP] >UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani RepID=Q9NJG8_LEIDO Length = 949 Score = 139 bits (349), Expect = 1e-31 Identities = 83/175 (47%), Positives = 104/175 (59%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL-- 171 EEVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL Sbjct: 396 EEVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQ 453 Query: 172 -EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 348 E + ++ K EKKA KE ++AEAE R + DGR E V NFRVEPP LF GR Sbjct: 454 REKKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGR 505 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G HPL GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+D Sbjct: 506 GKHPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRD 559 [144][TOP] >UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN Length = 635 Score = 139 bits (349), Expect = 1e-31 Identities = 83/175 (47%), Positives = 104/175 (59%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL-- 171 EEVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL Sbjct: 81 EEVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQ 138 Query: 172 -EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 348 E + ++ K EKKA KE ++AEAE R + DGR E V NFRVEPP LF GR Sbjct: 139 REKKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGR 190 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G HPL GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+D Sbjct: 191 GKHPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRD 244 [145][TOP] >UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DTW1_TRYCR Length = 664 Score = 139 bits (349), Expect = 1e-31 Identities = 76/173 (43%), Positives = 105/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A + D+ E FR NFF+ +R +L K I LE CDF I + HL + Sbjct: 84 EEVATMFAVMREHDYYRNEIFRRNFFSSWREIL--DKRQHPIRRLELCDFEPIYQWHLRE 141 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 354 EKK T E K+ EAE+ + + + DG++E V NFRVEPP LF GRG Sbjct: 142 R------EKKLSRTKEEKKQLRLEAEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQ 195 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP+ GK+K+R++PED+T+N+ +PIP+ P GH W +++H VTWLA W+D Sbjct: 196 HPMMGKLKKRVEPEDITINIDEFSPIPK-PPEGHRWKEVLHEHNVTWLAMWRD 247 [146][TOP] >UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus RepID=UPI00006154BF Length = 769 Score = 138 bits (348), Expect = 2e-31 Identities = 66/171 (38%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 258 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 313 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 314 KAQTEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 372 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 373 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 422 [147][TOP] >UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK Length = 766 Score = 138 bits (348), Expect = 2e-31 Identities = 68/172 (39%), Positives = 104/172 (60%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ + + Sbjct: 255 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF--- 310 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K + E + Q + E K+ + E ER+ +++ ++D +E + NF++EPP LF GRG+H Sbjct: 311 --KAQTEARKQMSKEEKQKIKEENERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNH 368 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI PED+ +N ++ +P P PGH W ++ H++ VTWL W + Sbjct: 369 PKMGMLKRRIMPEDIIINCSKDSKVPP-PPPGHKWKEVRHDNKVTWLVSWTE 419 [148][TOP] >UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major RepID=Q4Q2K0_LEIMA Length = 634 Score = 138 bits (348), Expect = 2e-31 Identities = 79/171 (46%), Positives = 100/171 (58%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A + D+ E FR NFF +R +L K I LE CDF I + Sbjct: 81 EEVATMFAVMKEHDYYRMEVFRRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQ 138 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + KK + K + A KE ++AEAE R + DGR E V NFRVEPP LF GRG HP Sbjct: 139 REKKLSRTKEEKKAI-KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHP 194 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 L GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+D Sbjct: 195 LMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRD 244 [149][TOP] >UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC Length = 998 Score = 138 bits (348), Expect = 2e-31 Identities = 77/179 (43%), Positives = 103/179 (57%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L T HV F+ NFF DF+ +L T AK I KCDF Sbjct: 405 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRP 464 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + K+ EKK AE+K + + + L DGR++ VGNFRVEPP L Sbjct: 465 IFDYYD----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPAL 520 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++ Sbjct: 521 FRGRGEHPKTGRVKARVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQE 578 [150][TOP] >UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus norvegicus RepID=UPI0001B7BF13 Length = 760 Score = 138 bits (347), Expect = 2e-31 Identities = 66/171 (38%), Positives = 107/171 (62%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + Sbjct: 254 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF--- 309 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 310 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHKERIANFKIEPPGLFRGRGNHP 368 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 369 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 418 [151][TOP] >UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16 RepID=A8XXL4_CAEBR Length = 840 Score = 138 bits (347), Expect = 2e-31 Identities = 66/171 (38%), Positives = 109/171 (63%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA + ++ + +F +NF D+R L+ + K IT L KCDF+ H+ + Sbjct: 315 EECATFYAGVVNHEYSSQVQFNTNFMKDWRKLMTSGEREK-ITDLAKCDFT----HIVEY 369 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + +++ +KA T E+ + +E +A+ V + +A++DG +E + NFR+EPP +F GRG HP Sbjct: 370 QNEQREIRKAMTKEEKAKIKEEKAQEVVDYGIAIIDGHKEKIANFRIEPPGVFRGRGGHP 429 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RI PEDV +N G ++ IP+ P+ GH W ++ H++ V+WL W + Sbjct: 430 KMGFIKKRIVPEDVIVNCGKDSVIPKPPL-GHKWKEVRHDNTVSWLCSWTE 479 [152][TOP] >UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA Length = 829 Score = 138 bits (347), Expect = 2e-31 Identities = 70/172 (40%), Positives = 104/172 (60%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D++ + T +IT+L KCDF+ + + Sbjct: 310 EEVATFFAKMLDHEYTTKDIFRKNFFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF--- 365 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K+++E + T E K +AE ER+ Q + ++D +E + NFR+EPP LF GRGDH Sbjct: 366 --KEQSEARKNMTKEEKLKIKAENERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDH 423 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P GK+K+RI PED+ +N ++ IP P GH W ++ H+ VTWL W + Sbjct: 424 PKMGKLKKRIMPEDIIINCSKDSKIPVAPA-GHKWKEVRHDGKVTWLVSWTE 474 [153][TOP] >UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0 Length = 758 Score = 137 bits (346), Expect = 3e-31 Identities = 66/171 (38%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + Sbjct: 247 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF--- 302 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 303 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 361 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 362 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 411 [154][TOP] >UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR Length = 664 Score = 137 bits (346), Expect = 3e-31 Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 177 EEVAT +A + D+ E FR NFF+ +R +L + I LE CDF I + HL + Sbjct: 84 EEVATMFAVMREHDYYRNEIFRRNFFSSWREILDRRQHP--IRRLELCDFEPIYQWHLRE 141 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 354 EKK T E K+ EAE+ + + + DG++E V NFRVEPP LF GRG Sbjct: 142 R------EKKLSRTKEEKKQLRLEAEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQ 195 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP+ GK+K+R++PED+T+N+ +PIP+ P GH W +++H VTWLA W+D Sbjct: 196 HPMMGKLKKRVEPEDITINIDEFSPIPK-PPEGHRWKEVLHEHNVTWLAMWRD 247 [155][TOP] >UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2 Tax=Emericella nidulans RepID=C8VUK1_EMENI Length = 871 Score = 137 bits (346), Expect = 3e-31 Identities = 75/179 (41%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVA F+ S L T H F+ NFFADF+ +L T AK I KCDF Sbjct: 278 EEVAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQP 337 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + ++ EKKA AE+K + + + + + DGR++ VGNFRVEPP+L Sbjct: 338 IFQYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSL 393 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 394 FRGRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQE 451 [156][TOP] >UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT Length = 767 Score = 137 bits (346), Expect = 3e-31 Identities = 66/171 (38%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + Sbjct: 256 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF--- 311 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 312 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 370 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 371 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 420 [157][TOP] >UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE Length = 767 Score = 137 bits (346), Expect = 3e-31 Identities = 66/171 (38%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + Sbjct: 256 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF--- 311 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 312 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 370 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 371 KMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTE 420 [158][TOP] >UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5FAF Length = 573 Score = 137 bits (345), Expect = 4e-31 Identities = 70/172 (40%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 62 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NE 115 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDH Sbjct: 116 YFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDH 175 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W + Sbjct: 176 PKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTE 226 [159][TOP] >UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F97 Length = 790 Score = 137 bits (345), Expect = 4e-31 Identities = 70/172 (40%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 294 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NE 347 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDH Sbjct: 348 YFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDH 407 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W + Sbjct: 408 PKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTE 458 [160][TOP] >UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F96 Length = 767 Score = 137 bits (345), Expect = 4e-31 Identities = 70/172 (40%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 256 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NE 309 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDH Sbjct: 310 YFKAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDH 369 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W + Sbjct: 370 PKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTE 420 [161][TOP] >UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I, mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B7ZAR5_HUMAN Length = 503 Score = 137 bits (345), Expect = 4e-31 Identities = 70/162 (43%), Positives = 103/162 (63%), Gaps = 1/162 (0%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L ++ KE FR NFF+D+R +A + +VI SL+KCDF+ I + D+ A +K + Sbjct: 2 LDHEYTTKEVFRKNFFSDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59 Query: 211 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 387 E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP G +KRRI Sbjct: 60 ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115 Query: 388 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTE 156 [162][TOP] >UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia guttata RepID=UPI000194BDF0 Length = 662 Score = 137 bits (344), Expect = 5e-31 Identities = 67/172 (38%), Positives = 105/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + ++ Sbjct: 151 EEIATFYAKMLNHEYTTKEIFQNNFFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEK 209 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +K K E K+ + EA+++++ + ++DG E +GNF+ EPP LF GRG+H Sbjct: 210 NEARKGLPK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGEH 264 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +K+RI PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 265 PKMGMLKKRIMPEDVIINCSKDSKIPE-PPEGHKWKEVRFDNTVTWLASWTE 315 [163][TOP] >UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio RepID=UPI000176075D Length = 531 Score = 137 bits (344), Expect = 5e-31 Identities = 70/172 (40%), Positives = 104/172 (60%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLED 177 EEVA ++A L ++ KE FR+NFF D+R + + ++I L+KCDF + A H E Sbjct: 20 EEVALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEK 78 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +A+K K+ E+ +EA + V ++ ++D E +GNF++EPP LF GRGDH Sbjct: 79 VEARKNLSKE-----EKLVNKEANQKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDH 133 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +K+RI+PEDV +N + IPE P GH W ++ H+ VTWLA W + Sbjct: 134 PKQGMLKKRIRPEDVIINCSKESRIPEAPA-GHKWKEVRHDKTVTWLASWTE 184 [164][TOP] >UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio RepID=UPI0001A2C88D Length = 609 Score = 137 bits (344), Expect = 5e-31 Identities = 70/172 (40%), Positives = 104/172 (60%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLED 177 EEVA ++A L ++ KE FR+NFF D+R + + ++I L+KCDF + A H E Sbjct: 98 EEVALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEK 156 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 +A+K K+ E+ +EA + V ++ ++D E +GNF++EPP LF GRGDH Sbjct: 157 VEARKNLSKE-----EKLVNKEANQKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDH 211 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +K+RI+PEDV +N + IPE P GH W ++ H+ VTWLA W + Sbjct: 212 PKQGMLKKRIRPEDVIINCSKESRIPEAPA-GHKWKEVRHDKTVTWLASWTE 262 [165][TOP] >UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus (Silurana) tropicalis RepID=Q0V9D3_XENTR Length = 495 Score = 137 bits (344), Expect = 5e-31 Identities = 67/171 (39%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA+F+A L ++ KE FR+N+F D+R + + VIT L KCDF+ + + + Sbjct: 170 EEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG- 227 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K EKK ++ ++ + +E + ++++ +D E +GNF++EPP LF GRGDHP Sbjct: 228 ---KMEEKKNKSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHP 284 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RI PED+ +N ++ IPE P PGH W ++ H++ VTWLA W + Sbjct: 285 KQGMLKKRILPEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTE 334 [166][TOP] >UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA Length = 969 Score = 137 bits (344), Expect = 5e-31 Identities = 69/170 (40%), Positives = 105/170 (61%), Gaps = 1/170 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FYA L+ D+ K+ F NFF D+R + + + IT LEKC+F + A+ + Sbjct: 479 EEVAGFYARMLEHDYTSKQAFNDNFFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEI 537 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 AE+ + E K A +A E++ +++ + ++DG +E +GNF++EPP LF GRG+H Sbjct: 538 -----AEQNRNRSKEEKAALKAANEQLTKEYGICVIDGHKEKIGNFKIEPPGLFRGRGEH 592 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 P G VKRR+ PEDV +N ++ IP P PG W ++ H++ V+WLA W Sbjct: 593 PKMGLVKRRVMPEDVIINCSQDSKIPS-PPPGRRWKEVRHDNTVSWLASW 641 [167][TOP] >UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis RepID=A4HB62_LEIBR Length = 637 Score = 137 bits (344), Expect = 5e-31 Identities = 75/171 (43%), Positives = 96/171 (56%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A + D+ E FR NFF +R +L K I LE CDF I E Sbjct: 81 EEVATMFAVMKEHDYYRMEAFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWYLAE 138 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + KK +T E+K +E + + + DGR E V NFRVEPP LF GRG HP Sbjct: 139 REKKLN----RTKEEKKSIKEKQDMDAEPYRYCMWDGRREQVANFRVEPPGLFRGRGKHP 194 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 L GK+K R+QPE +T+N+G A +P P GH WG + H+ VTWLA W+D Sbjct: 195 LMGKLKARVQPEGITINIGETAEVP-VPPAGHKWGAVQHDHTVTWLAMWRD 244 [168][TOP] >UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CUT4_ASPTN Length = 872 Score = 137 bits (344), Expect = 5e-31 Identities = 76/179 (42%), Positives = 105/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSR 156 EEVA F+ S L T H F+ NFF DF+ +L D K KV I +KCDF Sbjct: 279 EEVAGFFGSMLNSTQHTENPTFQKNFFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQP 338 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E K+ EK+ AE+K + + E+ + + DGR++ VGNFRVEPP+L Sbjct: 339 IFDYYE----AKRIEKRNLPAAEKKRLKAEKDEQEAPYMYCMWDGRKQKVGNFRVEPPSL 394 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 395 FRGRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQE 452 [169][TOP] >UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6H1W4_PENCW Length = 864 Score = 137 bits (344), Expect = 5e-31 Identities = 73/179 (40%), Positives = 111/179 (62%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEK-FRSNFFADFRALLA------DTKFAKV-ITSLEKCDFSR 156 EEVA+F+ + L + H ++ F+ NFF+DF+ ++ D+K KV I KCDF Sbjct: 270 EEVASFFGTMLNSTHNVENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKP 329 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + ++ EK+ AE+K A+ + E+ + + DGR++ VGNFRVEPP+L Sbjct: 330 IFEFYDAQRE----EKRHLPPAEKKAAKALKDEQEAPYQYCIWDGRKQKVGNFRVEPPSL 385 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G +A +P P PGH W ++ H+ TWLA W++ Sbjct: 386 FRGRGEHPKTGRVKTRVQPEQITINIGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQE 443 [170][TOP] >UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica RepID=UPI0000F2B3E5 Length = 916 Score = 136 bits (343), Expect = 7e-31 Identities = 68/172 (39%), Positives = 105/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + + IT+L KCDF++I + Sbjct: 405 EEVATFFAKMLDHEYTTKDIFRKNFFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF--- 460 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K + E ER+ +++ ++D E + NF++EPP LF GRG+H Sbjct: 461 --KAQSEARKQMSKEEKLKIKEENERLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNH 518 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W + Sbjct: 519 PKMGMLKRRIMPEDIIINCSKDAKVPP-PPPGHKWKEVRHDNKVTWLVSWTE 569 [171][TOP] >UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU Length = 767 Score = 136 bits (343), Expect = 7e-31 Identities = 69/172 (40%), Positives = 107/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + + Sbjct: 256 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGMNDYF--- 311 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDH Sbjct: 312 --KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDH 369 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 P G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W + Sbjct: 370 PKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTE 420 [172][TOP] >UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI Length = 871 Score = 136 bits (343), Expect = 7e-31 Identities = 75/179 (41%), Positives = 103/179 (57%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVA F+ S L T H F+ NFFADF+ +L T AK I KCDF Sbjct: 278 EEVAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQP 337 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + ++ EKKA AE+K + + + + + DGR++ VGNFRVEPP L Sbjct: 338 IFQYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPPL 393 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 394 FRGRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQE 451 [173][TOP] >UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina RepID=B2AY06_PODAN Length = 904 Score = 136 bits (343), Expect = 7e-31 Identities = 77/179 (43%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVATF+ + L T +V F+ NFF DFR +L +T AK I K DF++ Sbjct: 307 EEVATFFGAMLHSTQNVENPTFQKNFFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTK 366 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + KKA A+ AE+ E + EA + DGR+E VGNFRVEPP L Sbjct: 367 IFEYYKGLSEAKKARPAAEKKAEKAEKDKFEAP----YMYCKWDGRKEKVGNFRVEPPGL 422 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG VK+R+ PE VT+N+G A +P+ P GH W + H++ TWLA W++ Sbjct: 423 FRGRGEHPKTGTVKKRVMPEQVTINIGKEAKVPD-PPAGHKWKAVQHDNKATWLAMWQE 480 [174][TOP] >UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR Length = 1063 Score = 136 bits (342), Expect = 9e-31 Identities = 66/171 (38%), Positives = 100/171 (58%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L D+ K+ F +NFF DFR + K ++I KC+F + + E Sbjct: 554 EEAATFYAKMLNHDYCTKDVFNTNFFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAE 612 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+KA K + ++ E V+++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 613 SEKRKAATKEEKLLKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHP 668 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI DV++N G + +P+ P+ G W ++ H++ VTWLA W + Sbjct: 669 KMGMIKRRIAAADVSINCGKQSKVPQPPM-GGRWKEVRHDNTVTWLASWTE 718 [175][TOP] >UniRef100_B7Z9E8 cDNA, FLJ78812, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B7Z9E8_HUMAN Length = 503 Score = 136 bits (342), Expect = 9e-31 Identities = 70/162 (43%), Positives = 102/162 (62%), Gaps = 1/162 (0%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ A +K + Sbjct: 2 LDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59 Query: 211 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 387 E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP G +KRRI Sbjct: 60 ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115 Query: 388 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTE 156 [176][TOP] >UniRef100_B4DYD2 cDNA FLJ50294, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4DYD2_HUMAN Length = 503 Score = 136 bits (342), Expect = 9e-31 Identities = 70/162 (43%), Positives = 102/162 (62%), Gaps = 1/162 (0%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ A +K + Sbjct: 2 LDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59 Query: 211 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 387 E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP G +KRRI Sbjct: 60 ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115 Query: 388 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 PEDV +N ++ IPE P GH W ++ ++ VTWLA W + Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTE 156 [177][TOP] >UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis RepID=C5GB81_AJEDR Length = 911 Score = 136 bits (342), Expect = 9e-31 Identities = 75/179 (41%), Positives = 102/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + + AK I S + CDF Sbjct: 318 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKP 377 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + E + EKK AE+K + + E + + DGR++ VGNFRVEPP L Sbjct: 378 IFEYYE----AARLEKKNLPAAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 433 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G +A +P P PGH W ++ H+ TWLA W++ Sbjct: 434 FRGRGEHPKTGKVKTRVMPEQITINIGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQE 491 [178][TOP] >UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI00005A45B7 Length = 1004 Score = 135 bits (341), Expect = 1e-30 Identities = 65/171 (38%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 493 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 548 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 549 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 607 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P GH W ++ H++ VTWL W + Sbjct: 608 KMGMLKRRIMPEDIIINCSKDAKVPS-PPTGHKWKEVRHDNKVTWLVSWTE 657 [179][TOP] >UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30 Length = 752 Score = 135 bits (341), Expect = 1e-30 Identities = 65/171 (38%), Positives = 106/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + Sbjct: 241 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF--- 296 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 297 KAQSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHP 355 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI PED+ +N +A +P P GH W ++ H++ VTWL W + Sbjct: 356 KMGMLKRRIMPEDIIINCSKDAKVPS-PPTGHKWKEVRHDNKVTWLVSWTE 405 [180][TOP] >UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE Length = 469 Score = 135 bits (341), Expect = 1e-30 Identities = 68/171 (39%), Positives = 105/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF++ L ++ K+ FR NFF D+R + + +K IT L KCDFS + + Sbjct: 247 EEVATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF--- 302 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A +KA T E+ + +E ++++ ++D +E + NFR+EPP LF GRGDHP Sbjct: 303 KAQSEA-RKAMTKEEKLKIKEENERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHP 361 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI+PED+ +N ++ P P PG W ++ H++ VTWL W + Sbjct: 362 KMGMLKRRIRPEDIIINCSKDSKHP-TPPPGTKWKEVRHDNKVTWLVSWTE 411 [181][TOP] >UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE Length = 758 Score = 135 bits (341), Expect = 1e-30 Identities = 68/171 (39%), Positives = 105/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF++ L ++ K+ FR NFF D+R + + +K IT L KCDFS + + Sbjct: 247 EEVATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF--- 302 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KA+ +A +KA T E+ + +E ++++ ++D +E + NFR+EPP LF GRGDHP Sbjct: 303 KAQSEA-RKAMTKEEKLKIKEENERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHP 361 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRRI+PED+ +N ++ P P PG W ++ H++ VTWL W + Sbjct: 362 KMGMLKRRIRPEDIIINCSKDSKHP-TPPPGTKWKEVRHDNKVTWLVSWTE 411 [182][TOP] >UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax adhaerens RepID=B3S6N7_TRIAD Length = 560 Score = 135 bits (341), Expect = 1e-30 Identities = 72/174 (41%), Positives = 104/174 (59%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLE 174 EE A FYA L D+ K+ F NF+ DFR + A+ KV + KCDFS+I Sbjct: 49 EEAAGFYAKMLDHDYTQKKIFNDNFWTDFRKEMTPAEKNHIKVFS---KCDFSKIA---- 101 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRG 351 E K KAE++ + E K + E E + Q + ++DG + VGNF++EPP LF GRG Sbjct: 102 -EYYKMKAEERRNMSKEEKNKLKKENEELMQEYGFCIIDGHRQRVGNFKIEPPGLFRGRG 160 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 DHP GK+KRRI+ +D+ +N+G +A +P P PG W ++ +++ VTWLA W + Sbjct: 161 DHPKQGKIKRRIEAKDIIINIGKDAKLP-APPPGQKWKEVRYDNKVTWLASWTE 213 [183][TOP] >UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus RepID=B0WA62_CULQU Length = 962 Score = 135 bits (341), Expect = 1e-30 Identities = 68/171 (39%), Positives = 103/171 (60%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FYA ++ ++ K+ F NFF D+R + ++ K I L+KC+F + A+ D Sbjct: 456 EEVAGFYARMIEHEYTSKDVFNDNFFKDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDL 514 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K + K + A KE EA V+++ + +DG +E +GNFR+EPP LF GRG+HP Sbjct: 515 SEKNRNRSKEEKLA-LKEQNEA---LVKEYGICNIDGHKEKIGNFRIEPPGLFRGRGEHP 570 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G VKRR+ PEDV +N ++ P+ P GH W ++ H++ V+WLA W + Sbjct: 571 KMGLVKRRVMPEDVIINCAKDSVYPKAP-EGHRWKEVRHDNTVSWLASWTE 620 [184][TOP] >UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG Length = 806 Score = 135 bits (339), Expect = 2e-30 Identities = 74/190 (38%), Positives = 107/190 (56%), Gaps = 19/190 (10%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + + + Sbjct: 222 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQ 280 Query: 181 KAKKKAEKKAQTTAE------RKEAREA------------EAERV-RQFTVALVDGREET 303 +KA K + R+ R A E ER+ +QF ++D +E Sbjct: 281 TEARKAMTKEEKLVSPHPHSCRRRLRAAGFIPSAFQKIKEENERILQQFGFCIMDNHKER 340 Query: 304 VGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNS 483 + NFR+EPP LF GRGDHP G +KRRI+PED+ +N ++ PE P PG W ++ H++ Sbjct: 341 IANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDN 399 Query: 484 CVTWLAGWKD 513 VTWL W + Sbjct: 400 KVTWLVSWTE 409 [185][TOP] >UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01 RepID=C1H484_PARBA Length = 900 Score = 135 bits (339), Expect = 2e-30 Identities = 76/179 (42%), Positives = 101/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF Sbjct: 307 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKP 366 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I E + EKKA AE+K + + E + + DGR++ VGNFRVEPP L Sbjct: 367 IFEFYE----AARLEKKALPAAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 422 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 423 FRGRGEHPKTGKVKTRVMPEQITINIGKEAKVP-TPPAGHKWKEVKHDQEGTWLAMWQE 480 [186][TOP] >UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294 Length = 786 Score = 134 bits (338), Expect = 3e-30 Identities = 69/173 (39%), Positives = 104/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRA-LLADTKFAKVITSLEKCDFSRIEAHLED 177 EEVATF+A L ++ K+ FR NFF D++ + AD + +IT+L KCDF+ + + Sbjct: 273 EEVATFFAKMLDHEYTTKDIFRKNFFKDWKKEMTADER--NLITNLGKCDFNAMSQYF-- 328 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 354 K+++E + T E K+ + E ER+ Q + ++D E + NFR+EPP LF GRGD Sbjct: 329 ---KEQSEARKNMTKEEKQKIKEENERLLQEYGFCVMDNHRERIANFRIEPPGLFRGRGD 385 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP GK+K+RI PED+ +N ++ P P GH W ++ H+ VTWL W + Sbjct: 386 HPKMGKLKKRIMPEDIIINCSKDSKYPVAPA-GHKWKEVRHDGKVTWLVSWTE 437 [187][TOP] >UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI Length = 871 Score = 134 bits (338), Expect = 3e-30 Identities = 74/179 (41%), Positives = 103/179 (57%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVA F+ S L T H F+ NFFADF+ +L T AK I KCD Sbjct: 278 EEVAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQP 337 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + ++ EKKA AE+K + + + + + DGR++ VGNFRVEPP+L Sbjct: 338 IFQYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSL 393 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 394 FRGRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQE 451 [188][TOP] >UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum RepID=Q5C1T3_SCHJA Length = 330 Score = 134 bits (337), Expect = 4e-30 Identities = 66/169 (39%), Positives = 100/169 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FYA L D+ KE F NFF D+ + + + + I SL KCDF + + Sbjct: 167 EEVAGFYARMLDHDYTTKEVFNHNFFHDWVKTMNEEE-RRTIKSLSKCDFQEMHQYF--- 222 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K E+K +T E+++ +E + ++ ++DG ++ +GNFR+EPP LF GRG+HP Sbjct: 223 -LKLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHP 281 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 G +K+RI PEDV +N ++ +P P GH W ++ H++ VTWLA W Sbjct: 282 KMGMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACW 329 [189][TOP] >UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni RepID=C4Q6C8_SCHMA Length = 587 Score = 134 bits (337), Expect = 4e-30 Identities = 66/171 (38%), Positives = 101/171 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FYA L D+ KE F NFF D+ + + + + I SL KCDF + + Sbjct: 175 EEVAGFYARMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF--- 230 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K E+K +T E+++ +E + ++ ++DG ++ +GNFR+EPP LF GRG+HP Sbjct: 231 -LKLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHP 289 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RI PEDV +N ++ +P P GH W ++ H++ VTWLA W + Sbjct: 290 KMGMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACWTE 339 [190][TOP] >UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni RepID=C4Q6C7_SCHMA Length = 652 Score = 134 bits (337), Expect = 4e-30 Identities = 66/171 (38%), Positives = 101/171 (59%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA FYA L D+ KE F NFF D+ + + + + I SL KCDF + + Sbjct: 175 EEVAGFYARMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF--- 230 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K E+K +T E+++ +E + ++ ++DG ++ +GNFR+EPP LF GRG+HP Sbjct: 231 -LKLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHP 289 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +K+RI PEDV +N ++ +P P GH W ++ H++ VTWLA W + Sbjct: 290 KMGMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACWTE 339 [191][TOP] >UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7EXF7_SCLS1 Length = 911 Score = 134 bits (337), Expect = 4e-30 Identities = 74/179 (41%), Positives = 101/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EE+A F+ + L + H V F+ NFF DF + T AK I K DF Sbjct: 314 EEIAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKP 373 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + K E+KA++ AE+K + A+ E + + DGR+E VGNFRVEPP L Sbjct: 374 IFEYYDG----KSTERKARSAAEKKAEKAAKDEAEAPYKTCIWDGRKEDVGNFRVEPPGL 429 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P GH W I H++ TWLA W++ Sbjct: 430 FRGRGEHPKTGKVKLRVTPEQITINIGKEATVPS-PPEGHKWKAIQHDNKATWLAMWQE 487 [192][TOP] >UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R0K7_MAGGR Length = 906 Score = 134 bits (337), Expect = 4e-30 Identities = 80/179 (44%), Positives = 100/179 (55%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EEVATF+ S L T +V F NFF F+ L T AK I EK DF Sbjct: 308 EEVATFFGSMLHSTQNVENPTFIKNFFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKP 367 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I H + + KKA K + AE KEAR+ E + DGR+E VGNFRVEPP L Sbjct: 368 IFQHFQAQSEAKKARSKEEKKAE-KEARDKMEE---PYKYCKWDGRKEKVGNFRVEPPAL 423 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TG +K R+ PE VT+N+G A +PE P GH W + H++ TWLA W++ Sbjct: 424 FRGRGEHPKTGTIKERVPPEAVTINIGKGAKVPE-PPAGHKWKAVQHDNKATWLAMWQE 481 [193][TOP] >UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B3173 Length = 622 Score = 134 bits (336), Expect = 5e-30 Identities = 71/175 (40%), Positives = 103/175 (58%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I A Sbjct: 104 EEVALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAM---H 159 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 KAK +A K + E+ +EA + + ++ L+D E +GNF++EPP LF GRG+HP Sbjct: 160 KAKVEARKN-MSKEEKLVLKEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHP 218 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVP----GHNWGKIIHNSCVTWLAGWKD 513 GK+K+RIQPEDV +N + E +P GH W ++ H++ VTWLA W + Sbjct: 219 KQGKLKKRIQPEDVIINCSNSRVDRESRIPVPPAGHRWKEVRHDNTVTWLASWTE 273 [194][TOP] >UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A49 Length = 692 Score = 133 bits (335), Expect = 6e-30 Identities = 70/178 (39%), Positives = 100/178 (56%), Gaps = 7/178 (3%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLED 177 EEVA F+A L ++ K+ FR NFF D+R + D + +I L KCDF I A H Sbjct: 119 EEVALFFAQMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAMHKAK 177 Query: 178 EKAKKKAEKKAQTTAE------RKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLF 339 +A+K K+ + + +EA + V +F L+D E +GNF++EPP LF Sbjct: 178 VEARKNMTKEEKQVCNIHFIMLKNALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLF 237 Query: 340 LGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GRG+HP G +K+RIQPED+ +N A IP P GH W ++ H++ VTWL W + Sbjct: 238 RGRGEHPKQGMLKKRIQPEDIIINCSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTE 294 [195][TOP] >UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66 RepID=B6ABX7_9CRYT Length = 660 Score = 133 bits (335), Expect = 6e-30 Identities = 71/173 (41%), Positives = 105/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+AT++A L T+ KE+F N F + + + +KCDFS I+ H ++E Sbjct: 88 EEIATYWAQILDTEWSSKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEE 147 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K +KK K Q +++ E+E+ + ALVD +E VGNFR+EPP LF GRG+HP Sbjct: 148 KERKKNMNKEQKEQQKRIKNESESP----YIYALVDWIKEKVGNFRIEPPGLFRGRGEHP 203 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIP--ECPVPGHNWGKIIHNSCVTWLAGWKD 513 +G +K+RI E+VTLN+ +AP+P + + GH W + H+S VTWLA +KD Sbjct: 204 KSGMLKKRIFSEEVTLNVAEDAPVPKVDSSIIGHAWKDVFHDSNVTWLAYYKD 256 [196][TOP] >UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18 RepID=C1GKM6_PARBD Length = 825 Score = 133 bits (335), Expect = 6e-30 Identities = 75/179 (41%), Positives = 100/179 (55%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I E + EKKA E+K + + E + + DGR++ VGNFRVEPP L Sbjct: 372 IFEFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 427 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 428 FRGRGEHPKTGKVKTRVMPEQITINIGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQE 485 [197][TOP] >UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03 RepID=C0SEQ3_PARBP Length = 905 Score = 133 bits (335), Expect = 6e-30 Identities = 75/179 (41%), Positives = 100/179 (55%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I E + EKKA E+K + + E + + DGR++ VGNFRVEPP L Sbjct: 372 IFEFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPAL 427 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G A +P P GH W ++ H+ TWLA W++ Sbjct: 428 FRGRGEHPKTGKVKTRVMPEQITINIGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQE 485 [198][TOP] >UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE Length = 966 Score = 133 bits (334), Expect = 8e-30 Identities = 67/171 (39%), Positives = 100/171 (58%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A FYA L+ ++ K+ F NFF D+R + ++ K I L+KC+F + H + Sbjct: 461 EEIAGFYARMLEHEYTSKDAFNDNFFKDWRKSMTSSEREK-IKDLKKCNFRSMHKHFAEI 519 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + K Q A KE EA ++++ +DG +E +GNFR+EPP LF GRG+HP Sbjct: 520 SEANRNRTKEQKLA-LKEQNEA---LMKEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHP 575 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G VKRR+ PEDV +N G + P+ P GH W ++ H++ V+WLA W + Sbjct: 576 KMGMVKRRVMPEDVIINCGKESVWPKAP-EGHRWKEVRHDNSVSWLASWTE 625 [199][TOP] >UniRef100_A7SLG4 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SLG4_NEMVE Length = 502 Score = 133 bits (334), Expect = 8e-30 Identities = 64/159 (40%), Positives = 98/159 (61%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L+ D+ KE F NFF+D+R + + + K I L+ CDF + + E K E+K Sbjct: 2 LEHDYTSKEIFNKNFFSDWRKEMTEEE-RKHIKDLKNCDFKEMHKYFE----MKNEERKN 56 Query: 211 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 390 T E+ E ++ E + ++ ++D ++ VGNF++EPP LF GRGDHP GK+K+R+ Sbjct: 57 MTKEEKLEIKKKNEEILNEYGFCMMDHHKQRVGNFKIEPPGLFRGRGDHPKQGKLKKRVM 116 Query: 391 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 PE+VT+N+G +A +P+ P GH W K+I + VTWLA W Sbjct: 117 PEEVTINIGKDAKVPD-PPAGHKWKKVICDDTVTWLACW 154 [200][TOP] >UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana B05.10 RepID=A6S3Q9_BOTFB Length = 912 Score = 133 bits (334), Expect = 8e-30 Identities = 74/179 (41%), Positives = 101/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 156 EE+A F+ + L + H V F+ NFF DF + T AK I K DF Sbjct: 315 EEIAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKP 374 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 I + + + ++KA A+ AE+ EAEA + + DGR+E VGNFRVEPP L Sbjct: 375 IFEYYDGKSTERKARSAAEKKAEKALKDEAEAP----YKTCIWDGRKEDVGNFRVEPPGL 430 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRG+HP TGKVK R+ PE +T+N+G +A +P P GH W I H++ TWLA W++ Sbjct: 431 FRGRGEHPKTGKVKLRVTPEQITINIGKDATVPS-PPEGHKWKAIQHDNKATWLAMWQE 488 [201][TOP] >UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SIQ6_9PEZI Length = 891 Score = 132 bits (332), Expect = 1e-29 Identities = 69/175 (39%), Positives = 108/175 (61%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQT-DHVLKEKFRSNFFADFRALLADTKFA--KVITSLEKCDFSRIEAH- 168 EE A F+ S + ++V F+ NFF DFR ++ + A K ++ DF +I Sbjct: 295 EEAAWFFGSMFHSKNNVDNPTFQKNFFEDFREVIKEHGSATDKDGKKVDIKDFHKINWQP 354 Query: 169 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 348 + D ++ A +K +T E+K+ +E + R F L DGR+E +GNFRVEPP+LF GR Sbjct: 355 MADYAEQQSAMRKNRTKEEKKQIKEEKDAREEPFKYCLWDGRKEKMGNFRVEPPSLFRGR 414 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 GDHP TG++K+++ PE +T+N+G +A IP+ P GH W ++H++ TWLA W++ Sbjct: 415 GDHPKTGRIKKQVFPEQITINIGKDAKIPK-PPDGHKWKAVVHDNKATWLASWQE 468 [202][TOP] >UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F98 Length = 790 Score = 131 bits (330), Expect = 2e-29 Identities = 69/186 (37%), Positives = 108/186 (58%), Gaps = 15/186 (8%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAH 168 EEVATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +A Sbjct: 229 EEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGMNEYFKAQ 287 Query: 169 LEDEKAKKKAEKKA-----------QTTAERKEAREAEAERVRQFTVALVDGREETVGNF 315 E K K EK+ +T++ + +E ++++ ++D +E +GNF Sbjct: 288 SEARKQMSKEEKQVSLHSITCSPALKTSSHLNKIKEDNERILQEYGFCIMDNHKERIGNF 347 Query: 316 RVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTW 495 R+EPP LF GRGDHP G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTW Sbjct: 348 RIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTW 406 Query: 496 LAGWKD 513 LA W + Sbjct: 407 LASWTE 412 [203][TOP] >UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium parvum Iowa II RepID=Q5CY81_CRYPV Length = 653 Score = 131 bits (330), Expect = 2e-29 Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A++++ T+ KEKF +N F + EKC+F I+ + EDE Sbjct: 92 EEIASYWSVMKDTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDE 151 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KK K + ++K + E+ F ALVD +E VGNFR+EPP LF GRG+HP Sbjct: 152 KEAKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNFRIEPPGLFKGRGEHP 207 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCVTWLAGWKD 513 +G +KRRI PEDVTLN+ +AP+P+ P + GH W I H++ VTWLA ++D Sbjct: 208 KSGMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRD 260 [204][TOP] >UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis RepID=Q5CN58_CRYHO Length = 641 Score = 131 bits (330), Expect = 2e-29 Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A++++ T+ KEKF +N F + EKC+F I+ + EDE Sbjct: 80 EEIASYWSVMKDTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDE 139 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KK K + ++K + E+ F ALVD +E VGNFR+EPP LF GRG+HP Sbjct: 140 KEAKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNFRIEPPGLFKGRGEHP 195 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCVTWLAGWKD 513 +G +KRRI PEDVTLN+ +AP+P+ P + GH W I H++ VTWLA ++D Sbjct: 196 KSGMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRD 248 [205][TOP] >UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA Length = 1019 Score = 131 bits (330), Expect = 2e-29 Identities = 71/173 (41%), Positives = 93/173 (53%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLE 174 EE+A FYA KL+T H F NFF DF+ L + I S +K DF + + Sbjct: 200 EEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWR 259 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 354 K + KKA + RK E ++ + LVDG E+ VGN VEPP LFLGRG Sbjct: 260 SLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGA 319 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP GKVKRRI P D+T+N + P P+ P +W +++ VTWLA WK+ Sbjct: 320 HPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKE 372 [206][TOP] >UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE Length = 725 Score = 130 bits (328), Expect = 4e-29 Identities = 72/174 (41%), Positives = 102/174 (58%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ T++A + + + KE +R NF + L TKF L+K DF++I HLE + Sbjct: 80 EELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIREHLEQQ 132 Query: 181 KA---KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + K E+K Q ER + R + ALVDG E VGN+ +E P LF GRG Sbjct: 133 RLLRLNKSDEQKKQEKLERDQ-------RELFYGYALVDGCLERVGNYTLEQPTLFKGRG 185 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +HP G +K RI PE++T+NL AP+P+C +PGH+WGKI+H + VTWL + D Sbjct: 186 EHPKAGLLKARIFPEELTVNLSTQAPVPQCKLPGHSWGKIVHRNDVTWLFSYVD 239 [207][TOP] >UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PY85_MALGO Length = 877 Score = 129 bits (325), Expect = 9e-29 Identities = 71/173 (41%), Positives = 93/173 (53%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLE 174 EEVA FYA KL++ H F NFF DF L K I EK DF + + Sbjct: 159 EEVAMFYAVKLESQHASNPIFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWM 218 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 354 K + KK+ + RK A ++ + LVDG E+ GN VEPP LFLGRG Sbjct: 219 SLKVAEAERKKSMAPSMRKAELAARRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGA 278 Query: 355 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HP G+VK RIQPE +T+N + P P+ P GH+WG+++ VTWLA W++ Sbjct: 279 HPKAGRVKTRIQPEQITINHSADHPPPK-PPKGHSWGEVVERKDVTWLALWRE 330 [208][TOP] >UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE Length = 596 Score = 129 bits (323), Expect = 1e-28 Identities = 71/174 (40%), Positives = 103/174 (59%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ T++A + + + KE +R NF + L TKF L+K DF++I+ +LE + Sbjct: 80 EELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIKEYLEQQ 132 Query: 181 KA---KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 + K E+K Q ER + R + ALVDG E VGN+ +E P LF GRG Sbjct: 133 RLLRLNKSDEQKKQEKLERDQ-------RELFYGYALVDGCLERVGNYTLEQPTLFKGRG 185 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +HP G +K RI PE++T+NL AP+P+C +PGH+WGKI+H + VTWL + D Sbjct: 186 EHPKAGLLKARIFPEELTVNLSTQAPVPQCKLPGHSWGKIVHRNDVTWLFSYVD 239 [209][TOP] >UniRef100_Q1WWG8 IP16129p (Fragment) n=1 Tax=Drosophila melanogaster RepID=Q1WWG8_DROME Length = 382 Score = 128 bits (322), Expect = 2e-28 Identities = 61/159 (38%), Positives = 94/159 (59%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L D+ KE F +NFF DFR + + ++I KC+F + + + E K+KA K Sbjct: 2 LNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKE 60 Query: 211 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 390 + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G +KRRIQ Sbjct: 61 EKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQ 116 Query: 391 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 DV++N G ++ +P P PG W ++ H++ VTWLA W Sbjct: 117 ASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASW 154 [210][TOP] >UniRef100_Q4V7M4 MGC115546 protein n=1 Tax=Xenopus laevis RepID=Q4V7M4_XENLA Length = 503 Score = 127 bits (320), Expect = 3e-28 Identities = 62/161 (38%), Positives = 98/161 (60%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L ++ KE FR+NFF D+R + + VIT L+KCDF+ + + + K EKK Sbjct: 2 LDHEYTTKEIFRNNFFVDWRKEMT-LEEKMVITDLDKCDFTEMFTYYKG----KMEEKKN 56 Query: 211 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 390 ++ ++ + +E + + ++ +D E +GNF++EPP LF GRGDHP G +K+RI Sbjct: 57 KSKEDKLKIKEENEKLLEEYGYCAMDHHREKIGNFKIEPPALFRGRGDHPKQGMLKKRIL 116 Query: 391 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 PED+ +N ++ IPE P PGH W ++ H++ VTWLA W + Sbjct: 117 PEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTE 156 [211][TOP] >UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH Length = 713 Score = 127 bits (319), Expect = 4e-28 Identities = 72/190 (37%), Positives = 100/190 (52%), Gaps = 19/190 (10%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+AT+++ L TD K K+R NF F K +K DF+ I+ HLE++ Sbjct: 171 EEMATYWSQTLGTDWEHKPKYRENFSKQFLDTFGKDKGKY---DFDKFDFTPIKIHLEEQ 227 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTV-ALVDGREETVGNFRVEPPNLFLGRGDH 357 K +K K E K + + ER+ + A++DG E VG F +EPP LF GRG+H Sbjct: 228 KEIRKNRSK-----EEKNQEKQKKERLSDYYAGAILDGFREKVGQFMIEPPTLFKGRGEH 282 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVP------------------GHNWGKIIHNS 483 P G +K RIQPE V +N+ +AP+P+C VP GH W +I+H Sbjct: 283 PKMGMMKGRIQPEAVVINISKDAPVPKCSVPDCIHICRQIFNEFPKKQLGHGWSEIVHKQ 342 Query: 484 CVTWLAGWKD 513 VTWLA +KD Sbjct: 343 DVTWLASYKD 352 [212][TOP] >UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI Length = 638 Score = 127 bits (318), Expect = 6e-28 Identities = 70/171 (40%), Positives = 93/171 (54%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE ATFYA L + F NFF DFR L + K+I KC+F I + E Sbjct: 117 EEAATFYAKMLNHECCRNRIFYRNFFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAE 175 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K+ A K + A+RK+ V ++ LVDG E + NFR+EPP LF GRGDHP Sbjct: 176 SNKRLAATKEEKLAKRKKNEAF----VNKYGFCLVDGHRERISNFRLEPPGLFRGRGDHP 231 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G +KRR+Q D+ +N G ++ IP P G W ++ H++ VTWLA W D Sbjct: 232 KMGMIKRRVQACDIIINCGRDSKIP-MPPRGQMWKEVRHDNTVTWLASWVD 281 [213][TOP] >UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7 Length = 839 Score = 126 bits (317), Expect = 7e-28 Identities = 71/179 (39%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIE---- 162 EE+AT++ S + +D+ KEKF NFF F L + K T L+K D S + Sbjct: 191 EELATYWCSAIGSDYCTKEKFILNFFKTFINSLENDNIIKQENETKLKKGDISNFKFIDF 250 Query: 163 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 342 ++D K + EK +T E++E ++ E+ +T ALVD E + + + EPP LF Sbjct: 251 MPIKDHLLKLREEKLNKTKEEKEEEKKMRMEKELPYTYALVDWIREKISSNKAEPPGLFR 310 Query: 343 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKD 513 GRG+HP G +K+RI PEDV +N+ +AP+P + GHNWG I H++ VTWLA +KD Sbjct: 311 GRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDNMCGHNWGDIYHDNKVTWLAYYKD 369 [214][TOP] >UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR Length = 874 Score = 126 bits (317), Expect = 7e-28 Identities = 73/179 (40%), Positives = 101/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSR 156 EE ATF+ L T +V F+ NFF DF+ +L T AK I EK DFS+ Sbjct: 277 EEAATFFGFMLNSTVNVENPTFQKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQ 336 Query: 157 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 336 + A+ + + K A A+ AE+ E + +A + DGR+E VGN RVE P L Sbjct: 337 LWAYKDAQTKAKNARSSAEKKAEKAERDKRDAP----YLYCKWDGRKEKVGNPRVEIPGL 392 Query: 337 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 F GRGDHP TG +K+R+ PE +T+N+G A +PE P GH W + H++ TWLA W++ Sbjct: 393 FRGRGDHPKTGCIKKRVLPEQITINIGKEAKVPE-PPAGHKWKAVQHDNKATWLAMWQE 450 [215][TOP] >UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO Length = 701 Score = 126 bits (316), Expect = 1e-27 Identities = 72/175 (41%), Positives = 100/175 (57%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK-FAKVITSLEKCDFSRIEAHLED 177 EEVATF+A + T++ E +R NF+ F ++ K +L+ CDFS I AHL+ Sbjct: 151 EEVATFWAQSIGTNYEESEIYRRNFWNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHLDM 210 Query: 178 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 E+ KKK +K+ K +E A++ + ALVD E VG+ R+EPP LF GRG H Sbjct: 211 EREKKKEQKEYY-----KALKEETAKKEHPYCYALVDWIREKVGSNRMEPPGLFKGRGLH 265 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPV---PGHNWGKIIHNSCVTWLAGWKD 513 P G +K R P V LNL +AP+P+ + GH W I H+S VTWLA ++D Sbjct: 266 PKQGLLKGRTFPHSVVLNLSKDAPVPKVSMFERQGHGWSDIFHDSSVTWLAYYRD 320 [216][TOP] >UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1 RepID=A9A2H9_NITMS Length = 551 Score = 125 bits (315), Expect = 1e-27 Identities = 78/175 (44%), Positives = 102/175 (58%), Gaps = 4/175 (2%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+ +A K T + + F+ NF ADF L D+KF K+ S E DFS ++ E Sbjct: 38 EEMIYQWAKKKDTPYAQDKVFQKNFTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKE 94 Query: 181 KAKK----KAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 348 K K K EKKA A+RKE RE E ++ VA++DG+E VGN+ EPP +F+GR Sbjct: 95 KDLKEMMTKEEKKA-IAAKRKELRE---ELKSKYGVAVMDGKEVEVGNYMAEPPGIFIGR 150 Query: 349 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G+HPL G+ K R+ +DVTLNLG A +PE WGKIIH+ WLA W D Sbjct: 151 GEHPLRGRWKPRVTAKDVTLNLGKEAKVPE-----GKWGKIIHDKDSMWLASWMD 200 [217][TOP] >UniRef100_UPI000069F011 UPI000069F011 related cluster n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069F011 Length = 503 Score = 125 bits (313), Expect = 2e-27 Identities = 61/161 (37%), Positives = 98/161 (60%) Frame = +1 Query: 31 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 210 L ++ KE FR+N+F D+R + + VIT L KCDF+ + + + K EKK Sbjct: 2 LDHEYTTKEIFRNNYFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKN 56 Query: 211 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 390 ++ ++ + +E + ++++ +D E +GNF++EPP LF GRGDHP G +K+RI Sbjct: 57 KSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRIL 116 Query: 391 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 PED+ +N ++ IPE P PGH W ++ H++ VTWLA W + Sbjct: 117 PEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTE 156 [218][TOP] >UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG RepID=B9Q6S5_TOXGO Length = 953 Score = 123 bits (309), Expect = 6e-27 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE------- 138 EEVA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 343 EEVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERM 402 Query: 139 ----KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETV 306 CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD E V Sbjct: 403 VGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKV 458 Query: 307 GNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSC 486 GN RVEPP LF GRG+HP G +KRRI DV LNL +AP+P +PGH W + H++ Sbjct: 459 GNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNS 518 Query: 487 VTWLAGWKD 513 VTWLA ++D Sbjct: 519 VTWLAFYRD 527 [219][TOP] >UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1 RepID=B9PWF4_TOXGO Length = 953 Score = 123 bits (309), Expect = 6e-27 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE------- 138 EEVA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 343 EEVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERM 402 Query: 139 ----KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETV 306 CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD E V Sbjct: 403 VGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKV 458 Query: 307 GNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSC 486 GN RVEPP LF GRG+HP G +KRRI DV LNL +AP+P +PGH W + H++ Sbjct: 459 GNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNS 518 Query: 487 VTWLAGWKD 513 VTWLA ++D Sbjct: 519 VTWLAFYRD 527 [220][TOP] >UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49 RepID=B6KM03_TOXGO Length = 953 Score = 123 bits (309), Expect = 6e-27 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE------- 138 EEVA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 343 EEVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERM 402 Query: 139 ----KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETV 306 CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD E V Sbjct: 403 VGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKV 458 Query: 307 GNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSC 486 GN RVEPP LF GRG+HP G +KRRI DV LNL +AP+P +PGH W + H++ Sbjct: 459 GNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNS 518 Query: 487 VTWLAGWKD 513 VTWLA ++D Sbjct: 519 VTWLAFYRD 527 [221][TOP] >UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio RepID=UPI0001A2BD10 Length = 349 Score = 123 bits (308), Expect = 8e-27 Identities = 65/150 (43%), Positives = 92/150 (61%), Gaps = 1/150 (0%) Frame = +1 Query: 61 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 240 FR F D + + + + K+IT+L KCDF+ I + +K EKK T KE Sbjct: 191 FRMFFACDCQEMTKEER--KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----KEVL 240 Query: 241 EAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLG 417 + EA R+ +F L+DG E +GNF++EPP LF GRG+HP G++K+RIQPEDV +N Sbjct: 241 KDEAARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCS 300 Query: 418 PNAPIPECPVPGHNWGKIIHNSCVTWLAGW 507 ++ IPE P GH W ++ H++ VTWLA W Sbjct: 301 KDSKIPE-PPAGHKWKRVQHDNTVTWLASW 329 [222][TOP] >UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L6G4_PLAKH Length = 924 Score = 122 bits (305), Expect = 2e-26 Identities = 68/179 (37%), Positives = 102/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITS--LEKCDFSRIE---- 162 EE+AT++ S + +D+ KEKF NFF F L + L+K D S + Sbjct: 225 EELATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDF 284 Query: 163 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 342 ++D K + EK +T E++E ++ +E+ T ALVD E + + + EPP LF Sbjct: 285 MPIKDHLVKLREEKLNRTKEEKEEEKKLRSEKELPHTYALVDWIREKISSNKAEPPGLFR 344 Query: 343 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKD 513 GRG+HP G +K+RI PEDV +N+ +AP+P + GH+WG I H++ VTWLA +KD Sbjct: 345 GRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYGDMCGHSWGDIYHDNKVTWLAYYKD 403 [223][TOP] >UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2) (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD Length = 620 Score = 121 bits (303), Expect = 3e-26 Identities = 65/171 (38%), Positives = 105/171 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFY KL ++ KE F++NFF+D+R + + +VI L++CDF+ I H D Sbjct: 47 EEVATFYGKKLDREYT-KEVFQNNFFSDWRKEMTAEE-GRVIKHLDRCDFTEIHRHSVD- 103 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K A +KA + E+++ +E E + ++F +++DG E +G+F+ EP ++ GRGDHP Sbjct: 104 ---KTASQKALSREEKQKLKEEEEKLQQEFGCSILDGHREKIGSFKTEPWSV-RGRGDHP 159 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 ++KRR+ PEDV +N ++ +PE P G W ++ + V WLA W + Sbjct: 160 KMERLKRRVLPEDVVINCSRDSTVPE-PPAGPQWKEVGCDCTVMWLAAWTE 209 [224][TOP] >UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1 Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO Length = 886 Score = 120 bits (301), Expect = 5e-26 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDF 150 EE+AT++ S + TD+ K+KF NFF F L + I++ + DF Sbjct: 243 EELATYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENENKIKNGDISNFKFIDF 302 Query: 151 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPP 330 I+ HL K + E+ +T E++E ++ E+ +T ALVD E + + + EPP Sbjct: 303 MTIKEHL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREKISSNKAEPP 358 Query: 331 NLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAG 504 LF GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H++ VTWLA Sbjct: 359 GLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAY 418 Query: 505 WKD 513 +KD Sbjct: 419 YKD 421 [225][TOP] >UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax RepID=A5KB33_PLAVI Length = 931 Score = 120 bits (300), Expect = 7e-26 Identities = 67/179 (37%), Positives = 102/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIE---- 162 EE+AT++ S + +D+ KEKF NFF F L + + L+K D S + Sbjct: 225 EELATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDF 284 Query: 163 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 342 ++D K + EK +T E++E ++ +E+ +T ALVD E + + + EPP LF Sbjct: 285 MPIKDHLVKLREEKLNRTKEEKEEEKKLRSEKELPYTYALVDWIREKISSNKAEPPGLFR 344 Query: 343 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKD 513 GRG+HP G +K+RI PEDV +N+ +AP+P + GH WG H++ VTWLA +KD Sbjct: 345 GRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDDMCGHCWGDTYHDNKVTWLAYYKD 403 [226][TOP] >UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi RepID=Q4XMK5_PLACH Length = 429 Score = 119 bits (299), Expect = 9e-26 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDF 150 EE+AT++ S + TD+ K+KF NFF F L + I++ + DF Sbjct: 218 EELATYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDF 277 Query: 151 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPP 330 I+ HL K + E+ +T E++E ++ E+ +T ALVD E + + + EPP Sbjct: 278 MTIKEHL----IKLRDERLNKTKEEKEEDKKIRMEKELPYTFALVDWIREKISSNKAEPP 333 Query: 331 NLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAG 504 LF GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H++ VTWLA Sbjct: 334 GLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAY 393 Query: 505 WKD 513 +KD Sbjct: 394 YKD 396 [227][TOP] >UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei RepID=Q4YYG2_PLABE Length = 805 Score = 119 bits (297), Expect = 2e-25 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDF 150 EE+AT++ S + TD+ KEKF NFF F L + I++ + DF Sbjct: 188 EELATYWCSVIGTDYCTKEKFILNFFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDF 247 Query: 151 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPP 330 I+ +L K + E+ +T E++E ++ E+ +T ALVD E + + + EPP Sbjct: 248 MTIKENL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREKISSNKAEPP 303 Query: 331 NLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAG 504 LF GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H++ VTWLA Sbjct: 304 GLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAY 363 Query: 505 WKD 513 +KD Sbjct: 364 YKD 366 [228][TOP] >UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA Length = 790 Score = 119 bits (297), Expect = 2e-25 Identities = 70/174 (40%), Positives = 103/174 (59%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A L+T+++ K KFR NF +D+R +L + +I +LE CDF+ I + E Sbjct: 252 EEVATMFAVMLETEYMTKPKFRENFMSDWRKILGEKH---IIQNLEDCDFTPIYEWHQRE 308 Query: 181 KAKKKAEKKAQTTAERKEAREAEAE-RVRQFTVALVDGRE-ETVGNFRVEPPNLFLGRGD 354 K KKK +T E+K +E + E R ++ A+VDG E VGNFRV + Sbjct: 309 KEKKKQ----MSTDEKKAIKEGKDETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWR 364 Query: 355 HPLTGKVKRRIQPE-DVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 +VK+ + + D+T+N+G +APIPE P+PG W +I H++ VTWLA W D Sbjct: 365 ASKDPQVKKNVYSQIDITINIGKDAPIPEPPIPGERWKEIRHDNTVTWLAFWND 418 [229][TOP] >UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva RepID=Q4N5U3_THEPA Length = 1003 Score = 117 bits (293), Expect = 5e-25 Identities = 69/174 (39%), Positives = 99/174 (56%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+AT +A + T++ + + NF+ F + F + L DFS I+ HLEDE Sbjct: 372 EEIATMWAQSIGTNYETSDIYCKNFWQVFVSKFEKDHFIRRC-KLTDVDFSLIKTHLEDE 430 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK K+ K ++ +A+R +F ALVD E V + ++EPP LF GRG HP Sbjct: 431 KQKKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSSNKLEPPGLFKGRGLHP 485 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNSCVTWLAGWKD 513 G +K R+ P+DV LNL +AP+P+ GH+W I H++ VTWLA +KD Sbjct: 486 KQGLLKARMFPKDVILNLSKDAPVPKVSNFQREGHSWKDIYHDNSVTWLAYYKD 539 [230][TOP] >UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata RepID=Q4UDP8_THEAN Length = 999 Score = 117 bits (292), Expect = 6e-25 Identities = 69/174 (39%), Positives = 99/174 (56%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+AT +A + T++ E + NF+ F + F + L DFS I+ HLE+E Sbjct: 373 EEIATMWAQSMGTNYETSEIYCKNFWQVFVSKFEKDHFIRRC-KLSDADFSLIKNHLEEE 431 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 K KKK K+ K ++ +A+R +F ALVD E V + ++EPP LF GRG HP Sbjct: 432 KQKKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSSNKLEPPGLFKGRGLHP 486 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNSCVTWLAGWKD 513 G +K R+ P+DV LNL +AP+P+ GH+W I H++ VTWLA +KD Sbjct: 487 KQGLLKSRMFPKDVILNLSKDAPVPKVTNFQREGHSWKDIYHDNSVTWLAYYKD 540 [231][TOP] >UniRef100_UPI000180B1AE PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Ciona intestinalis RepID=UPI000180B1AE Length = 482 Score = 113 bits (282), Expect = 8e-24 Identities = 52/130 (40%), Positives = 82/130 (63%) Frame = +1 Query: 124 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 303 IT L KC+F + ++ + +K E+KA++ E++E ++ + +F DG E Sbjct: 10 ITDLGKCNFRDVCSYFQ----QKSEERKARSKEEKQEEKKKNEALIEEFGFCDWDGHREK 65 Query: 304 VGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNS 483 +GNFR+EPP LF GRG+HP GK+K+RI PE++T+N N+ IP+ P GH W ++ H++ Sbjct: 66 IGNFRLEPPGLFRGRGNHPKMGKLKKRIIPENITINCSKNSKIPK-PPAGHKWKEVRHDN 124 Query: 484 CVTWLAGWKD 513 VTWL W + Sbjct: 125 AVTWLVSWTE 134 [232][TOP] >UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187E0BD Length = 265 Score = 111 bits (278), Expect = 2e-23 Identities = 61/140 (43%), Positives = 83/140 (59%), Gaps = 2/140 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLE 174 EEVA FYA+ ++TDH F NFF D+ +L D + +T +KCDF + + E Sbjct: 121 EEVAGFYAALIETDHAQDATFNKNFFEDWLKVLQDHPPRNGIKVTDFDKCDFRPMYEYFE 180 Query: 175 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 354 EKAKKKA + AE+KE ++ + E ++T +DGR+E VGNFRVEPP LF GRG+ Sbjct: 181 AEKAKKKA----MSAAEKKEIKKQKDEAEAKYTHCFLDGRKEKVGNFRVEPPGLFRGRGE 236 Query: 355 HPLTGKVKRRIQPEDVTLNL 414 HP G +K P + L L Sbjct: 237 HPKKGSLKVIGSPSLIALGL 256 [233][TOP] >UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum RepID=A0RU10_CENSY Length = 519 Score = 106 bits (265), Expect = 8e-22 Identities = 66/174 (37%), Positives = 92/174 (52%), Gaps = 3/174 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+A +A K T + + F+ NF DF L K + DFS ++ E Sbjct: 38 EEMAYQWAKKKDTPYAQDKVFQKNFARDFAKELGIKLLYKDL------DFSEAYRLVDME 91 Query: 181 KAKKKA---EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRG 351 K KK E+K + A+RKE RE + + +A++DG+E + ++ EPP +F+GRG Sbjct: 92 KDKKDMMTKEEKKEIAAKRKEIREGLKAK---YGIAVMDGKEVEIASYMAEPPGIFIGRG 148 Query: 352 DHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 HPL GK KRRI P+DV LN+G A P PG W KI+H W+A W D Sbjct: 149 KHPLRGKWKRRIGPQDVVLNMGTKAKAP----PG-KWKKIVHEKDGIWIAKWTD 197 [234][TOP] >UniRef100_B3TAG0 Putative eukaryotic DNA topoisomerase I, catalytic core n=1 Tax=uncultured marine crenarchaeote HF4000_APKG8D22 RepID=B3TAG0_9ARCH Length = 563 Score = 105 bits (263), Expect = 1e-21 Identities = 55/158 (34%), Positives = 89/158 (56%) Frame = +1 Query: 40 DHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTT 219 D + ++ F S+F F + +++ + SL + ++ E+++ K +KKA Sbjct: 62 DSIFQKNFVSDFAKTFNGKFKNLQYSDIDFSLA---YQLVDKEKEEKELLTKEDKKA-LA 117 Query: 220 AERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPED 399 +RKE RE E ++ ++DG+E +GN+ EPP +F+GRG+HP+ G+ K R+ +D Sbjct: 118 IKRKEIRE---EMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKD 174 Query: 400 VTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 VTLNLG A IPE WGKI+H+ W+A W D Sbjct: 175 VTLNLGKEAKIPEA-----KWGKIVHDRNSMWIASWMD 207 [235][TOP] >UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI Length = 557 Score = 104 bits (260), Expect = 3e-21 Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 2/173 (1%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA L T V +F NFF DFR+ L+ + TS + C+F +I +LE Sbjct: 105 EEVATFYAKVLGTPFVELSEFNENFFKDFRSCLSVEQRLH-FTSFDLCNFQKIHQYLE-- 161 Query: 181 KAKKKAEKKAQTTAERKEAR-EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 357 E++EAR + E E ++ +DG + FR++PP L R + Sbjct: 162 --------------EQQEARSQQELEEDERYGYCYIDGERHRINQFRIKPPGLCCPRKGY 207 Query: 358 PLT-GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 LT G ++ R+ PED+ +N A P P PGH W +++H+ V+WL W D Sbjct: 208 SLTMGMIRPRVLPEDIMINCDEYAE-PPAPPPGHRWRQVVHDRSVSWLYSWHD 259 [236][TOP] >UniRef100_B3T4E9 Putative eukaryotic DNA topoisomerase I, catalytic core n=1 Tax=uncultured marine crenarchaeote HF4000_ANIW133O4 RepID=B3T4E9_9ARCH Length = 563 Score = 104 bits (260), Expect = 3e-21 Identities = 60/154 (38%), Positives = 86/154 (55%), Gaps = 3/154 (1%) Frame = +1 Query: 61 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERK 231 F+ NF +DF A + KF + S DFS ++ EK +K+ E K +RK Sbjct: 65 FQKNFVSDF-AKTFNGKFKNLQYS--DIDFSLAHQLVDKEKEEKELLTKEDKKALAIKRK 121 Query: 232 EAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLN 411 E RE E ++ ++DG+E +GN+ EPP +F+GRG+HP+ G+ K R+ +DVTLN Sbjct: 122 EIRE---EMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLN 178 Query: 412 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 LG A IPE WGKI+H+ W+A W D Sbjct: 179 LGKEAKIPEA-----KWGKIVHDRNSMWIASWMD 207 [237][TOP] >UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO Length = 555 Score = 97.1 bits (240), Expect = 6e-19 Identities = 57/172 (33%), Positives = 84/172 (48%), Gaps = 1/172 (0%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATFYA ++T V +F NFF +FR+ L++ + + IT E C+F I +LE Sbjct: 102 EEVATFYAKLMKTAFVQMREFNQNFFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLE-- 158 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR-GDH 357 +R++ +E AE + + LVDG + FR+ P L R G Sbjct: 159 -------------CQREDEKERIAEENKLYGYCLVDGESRRITQFRISRPGLCCPRHGFS 205 Query: 358 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G ++ R+ PEDV +N N P P GH W ++H+ V W+ W D Sbjct: 206 TTMGTIRPRVLPEDVVINCDENEE-PPAPPCGHLWAAVVHDRTVRWVYAWND 256 [238][TOP] >UniRef100_UPI0000E48333 PREDICTED: similar to topoisomerase I alpha isoform 3, partial n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000E48333 Length = 440 Score = 96.3 bits (238), Expect = 1e-18 Identities = 43/94 (45%), Positives = 60/94 (63%) Frame = +1 Query: 232 EAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLN 411 E + E +++ DG +E +GNFRVEPP+LF GRG+HP G++K+RI PEDV +N Sbjct: 1 ENKRKNEEIQKEYGFCSFDGHKEKIGNFRVEPPSLFRGRGEHPKQGQLKKRIGPEDVIIN 60 Query: 412 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 ++ P P GH W K+IH + VTWLA W + Sbjct: 61 CSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTE 93 [239][TOP] >UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN Length = 240 Score = 85.9 bits (211), Expect = 1e-15 Identities = 55/171 (32%), Positives = 83/171 (48%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EE+AT YA + + + + F NFF DF++ L+ + I S E CDF++I +++ + Sbjct: 56 EELATLYAKFMNSPLAITDTFNENFFKDFQSHLS-RALRRQILSFELCDFTKIAFYIQGQ 114 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + ++K T R + +DG+ V +F + P+L+ R P Sbjct: 115 QG---VQRKLMTPMMR-----------NHYGYCTIDGKRHRVPHFSFDGPSLY--RRSGP 158 Query: 361 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G VK RIQPEDV +N N P P GH W +IH+ V WL W D Sbjct: 159 KYGMVKPRIQPEDVNINSQENG-APGAP-DGHTWKSVIHDRRVDWLWSWTD 207 [240][TOP] >UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major RepID=Q7YXA0_LEIMA Length = 200 Score = 85.5 bits (210), Expect = 2e-15 Identities = 56/126 (44%), Positives = 69/126 (54%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVAT +A + D+ E F NFF +R +L K I LE CDF I + Sbjct: 81 EEVATMFAVMKEHDYYRMEVFWRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQ 138 Query: 181 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 360 + KK + K + A KE ++AEAE R + DGR E V NFRVEPP LF GRG HP Sbjct: 139 REKKLSRTKEEKEAI-KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHP 194 Query: 361 LTGKVK 378 L GK+K Sbjct: 195 LMGKLK 200 [241][TOP] >UniRef100_Q56XA9 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q56XA9_ARATH Length = 396 Score = 68.2 bits (165), Expect = 3e-10 Identities = 26/49 (53%), Positives = 37/49 (75%) Frame = +1 Query: 367 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKD 513 G++K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D Sbjct: 1 GELKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWAD 49 [242][TOP] >UniRef100_Q504F2 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q504F2_DANRE Length = 321 Score = 55.5 bits (132), Expect = 2e-06 Identities = 32/80 (40%), Positives = 49/80 (61%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF++ L ++ K+ FR NFF D+R + + +K IT L KCDFS + + Sbjct: 247 EEVATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF--- 302 Query: 181 KAKKKAEKKAQTTAERKEAR 240 KA+ +A +KA T E+K+ + Sbjct: 303 KAQSEA-RKAMTKEEKKKKK 321 [243][TOP] >UniRef100_UPI000194EAF8 PREDICTED: similar to rCG63558, partial n=1 Tax=Taeniopygia guttata RepID=UPI000194EAF8 Length = 79 Score = 54.3 bits (129), Expect = 5e-06 Identities = 30/78 (38%), Positives = 44/78 (56%) Frame = +1 Query: 1 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 180 EEVATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ + + Sbjct: 8 EEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF--- 63 Query: 181 KAKKKAEKKAQTTAERKE 234 K ++E + Q + E K+ Sbjct: 64 --KAQSEARKQMSKEEKQ 79 [244][TOP] >UniRef100_B9Q1D7 Chloride channel, putative n=1 Tax=Toxoplasma gondii GT1 RepID=B9Q1D7_TOXGO Length = 1756 Score = 54.3 bits (129), Expect = 5e-06 Identities = 43/125 (34%), Positives = 53/125 (42%) Frame = -1 Query: 409 SASRPRAECGA*PYPSTDGPRDQGIGWAAPHGSCPPSLRDRPPERP*TDEHARPQPHGPP 230 S+S P + PS P ++P S PP PP P P P P Sbjct: 184 SSSSPSSSPSTSTSPSPSSPPSSSPPSSSPSSSSPPPSSSPPPSSP-------PSPSSAP 236 Query: 229 CARPSSAPSSPPSSSPFHPLSAPRSD*SHTFPGW*SPWQTWCPPGGL*SPRRSWIGTSPS 50 + S +PSSPPSSSP P SAP S T P SP + P SP S ++PS Sbjct: 237 SSSTSPSPSSPPSSSPPSPSSAPSSS---TSPSPSSPPPSSPPSSSSTSPSPS---SAPS 290 Query: 49 THGPS 35 + PS Sbjct: 291 SSPPS 295 [245][TOP] >UniRef100_B6KLS9 Voltage gated chloride channel domain-containing protein n=1 Tax=Toxoplasma gondii ME49 RepID=B6KLS9_TOXGO Length = 1779 Score = 53.5 bits (127), Expect = 8e-06 Identities = 44/129 (34%), Positives = 54/129 (41%), Gaps = 3/129 (2%) Frame = -1 Query: 415 PGSASRPRAECGA*PYPSTDGPRDQGIGWAAPHGSCPPSLRDRPPERP*TDEHARPQPHG 236 P S+S P + P PS+ P ++P S PP PP P P P Sbjct: 259 PPSSSSPSSSS---PPPSSSPPSSSPPSSSSPSSSSPPPSSSPPPPSP-PSSSTSPSPSS 314 Query: 235 PPCA---RPSSAPSSPPSSSPFHPLSAPRSD*SHTFPGW*SPWQTWCPPGGL*SPRRSWI 65 PP + PS PSSPPSSSP P S+P S S + P SP + P P S Sbjct: 315 PPSSSPPSPSPPPSSPPSSSP--PSSSPPSPPSPSSPPPSSPPSSSSPSSSSPPPSSSPP 372 Query: 64 GTSPSTHGP 38 SP + P Sbjct: 373 PPSPPSSSP 381