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[1][TOP]
>UniRef100_B9HSU8 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HSU8_POPTR
          Length = 462

 Score =  263 bits (673), Expect = 3e-69
 Identities = 129/141 (91%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISVAGATYKSMEFVG+TVESLTMEERMTLCNMVVEAGGKNGVVPADSTT+KYLE KT++ 
Sbjct: 215 ISVAGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTFKYLEDKTTLP 274

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD QARFLSEYRFD+SKLEPLVAKPHSPDNRALAREC+DVKIDRVYIGSCTGGKT
Sbjct: 275 YEPVYSDAQARFLSEYRFDISKLEPLVAKPHSPDNRALARECRDVKIDRVYIGSCTGGKT 334

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDFMA AK+FLASGK VKVPT
Sbjct: 335 EDFMAVAKVFLASGKKVKVPT 355

[2][TOP]
>UniRef100_UPI0001983BAD PREDICTED: similar to Os02g0125100 n=1 Tax=Vitis vinifera
           RepID=UPI0001983BAD
          Length = 508

 Score =  263 bits (672), Expect = 4e-69
 Identities = 130/141 (92%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMVVEAGGKNGVVPADSTT+KYLE KT V 
Sbjct: 261 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYLEDKTDVP 320

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD+QARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 321 YEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 380

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+F ASGK VKVPT
Sbjct: 381 EDFLAAAKVFHASGKKVKVPT 401

[3][TOP]
>UniRef100_A7QRJ3 Chromosome chr8 scaffold_150, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7QRJ3_VITVI
          Length = 424

 Score =  263 bits (672), Expect = 4e-69
 Identities = 130/141 (92%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMVVEAGGKNGVVPADSTT+KYLE KT V 
Sbjct: 215 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYLEDKTDVP 274

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD+QARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 275 YEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 334

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+F ASGK VKVPT
Sbjct: 335 EDFLAAAKVFHASGKKVKVPT 355

[4][TOP]
>UniRef100_C5XT62 Putative uncharacterized protein Sb04g002120 n=1 Tax=Sorghum
           bicolor RepID=C5XT62_SORBI
          Length = 507

 Score =  263 bits (671), Expect = 6e-69
 Identities = 127/141 (90%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMV+EAGGKNGVVPAD TT+KYLEGKTSV 
Sbjct: 260 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYLEGKTSVD 319

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD QARF S+YRFDVSKLEP+VAKPHSPDNRALARECKDVK+DRVYIGSCTGGKT
Sbjct: 320 YEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKVDRVYIGSCTGGKT 379

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+FLASGK VKVPT
Sbjct: 380 EDFLAAAKVFLASGKKVKVPT 400

[5][TOP]
>UniRef100_B9HKV5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HKV5_POPTR
          Length = 443

 Score =  262 bits (669), Expect = 1e-68
 Identities = 128/141 (90%), Positives = 135/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISVAGATYKSMEF GTTVESLTMEERMTLCNMV+EAGGKNGVVP DSTT+KYLE KTS+ 
Sbjct: 196 ISVAGATYKSMEFAGTTVESLTMEERMTLCNMVIEAGGKNGVVPPDSTTFKYLEDKTSLP 255

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD QARFL+EYRFDV+KLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 256 YEPVYSDAQARFLTEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 315

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDFMAAAK+FLASGK V+VPT
Sbjct: 316 EDFMAAAKVFLASGKKVRVPT 336

[6][TOP]
>UniRef100_B9SQS5 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS5_RICCO
          Length = 510

 Score =  261 bits (666), Expect = 2e-68
 Identities = 128/141 (90%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVGTTVESL MEERMTLCNMVVEAGGKNGV+P+DSTT+KYLE KTSV 
Sbjct: 263 ISVSGATYKSMEFVGTTVESLNMEERMTLCNMVVEAGGKNGVIPSDSTTFKYLEDKTSVP 322

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +EPVYSD++ARFLSEYRFDVSKLEPLVAKPHSPDN ALARECKDVKIDRVYIGSCTGGKT
Sbjct: 323 FEPVYSDEKARFLSEYRFDVSKLEPLVAKPHSPDNCALARECKDVKIDRVYIGSCTGGKT 382

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDFMAAAK+FLASGK VKVPT
Sbjct: 383 EDFMAAAKVFLASGKKVKVPT 403

[7][TOP]
>UniRef100_B4FG11 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B4FG11_MAIZE
          Length = 505

 Score =  260 bits (665), Expect = 3e-68
 Identities = 127/141 (90%), Positives = 135/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMV+EAGGKNGVVPAD TT+KYLEGKTSV 
Sbjct: 258 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYLEGKTSVD 317

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD QARF S+YRFDVSKLEP+VAKPHSPDNRA ARECKDVKIDRVYIGSCTGGKT
Sbjct: 318 YEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDVKIDRVYIGSCTGGKT 377

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+FLASGK VKVPT
Sbjct: 378 EDFLAAAKVFLASGKKVKVPT 398

[8][TOP]
>UniRef100_C4JBG7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4JBG7_MAIZE
          Length = 505

 Score =  260 bits (664), Expect = 4e-68
 Identities = 126/141 (89%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMVVEAGGKNGVVPAD TT+KYLEG+TSV 
Sbjct: 258 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYLEGRTSVD 317

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+PVYSD +ARF S+YRFDVSKLEP+VAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 318 YQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 377

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+FLASGK VKVPT
Sbjct: 378 EDFLAAAKVFLASGKKVKVPT 398

[9][TOP]
>UniRef100_B6U6T6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6U6T6_MAIZE
          Length = 504

 Score =  260 bits (664), Expect = 4e-68
 Identities = 127/141 (90%), Positives = 135/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMV+EAGGKNGVVPAD TT+KYLEGKTSV 
Sbjct: 257 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYLEGKTSVD 316

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD QARF S+YRFDVSKLEP+VAKPHSPDNRA ARECKDVKIDRVYIGSCTGGKT
Sbjct: 317 YEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDVKIDRVYIGSCTGGKT 376

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+FLASGK VKVPT
Sbjct: 377 EDFLAAAKLFLASGKKVKVPT 397

[10][TOP]
>UniRef100_B6TYJ6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6TYJ6_MAIZE
          Length = 492

 Score =  260 bits (664), Expect = 4e-68
 Identities = 126/141 (89%), Positives = 136/141 (96%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMVVEAGGKNGVVPAD TT+KYLEG+TSV 
Sbjct: 258 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYLEGRTSVD 317

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+PVYSD +ARF S+YRFDVSKLEP+VAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 318 YQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 377

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+FLASGK VKVPT
Sbjct: 378 EDFLAAAKVFLASGKKVKVPT 398

[11][TOP]
>UniRef100_UPI0001983576 PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI0001983576
          Length = 508

 Score =  259 bits (661), Expect = 8e-68
 Identities = 127/141 (90%), Positives = 135/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVGTTVESLTMEERMTLCNMV+EAGGKNGVVPADSTT+KYLE KTS+ 
Sbjct: 261 ISVSGATYKSMEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYLEDKTSLP 320

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD+QARFLSEYRFD+SKLEPLVAKPHSPD  ALARECKDVKIDRVYIGSCTGGKT
Sbjct: 321 YEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDKCALARECKDVKIDRVYIGSCTGGKT 380

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+F ASGK VKVPT
Sbjct: 381 EDFLAAAKVFHASGKKVKVPT 401

[12][TOP]
>UniRef100_Q6Z702 Os02g0125100 protein n=2 Tax=Oryza sativa RepID=Q6Z702_ORYSJ
          Length = 514

 Score =  259 bits (661), Expect = 8e-68
 Identities = 125/141 (88%), Positives = 134/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESL MEERMTLCNMV+EAGGKNGVVPAD TT+ YLEGKTSV 
Sbjct: 267 ISVSGATYKSMEFVGSTVESLNMEERMTLCNMVIEAGGKNGVVPADQTTFNYLEGKTSVE 326

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD QARF+S+YRFDVSKLEP++AKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 327 YEPVYSDAQARFVSDYRFDVSKLEPVIAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 386

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF AAAK+FLASGK VKVPT
Sbjct: 387 EDFFAAAKVFLASGKKVKVPT 407

[13][TOP]
>UniRef100_A7NXJ3 Chromosome chr5 scaffold_2, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7NXJ3_VITVI
          Length = 507

 Score =  259 bits (661), Expect = 8e-68
 Identities = 127/141 (90%), Positives = 135/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVGTTVESLTMEERMTLCNMV+EAGGKNGVVPADSTT+KYLE KTS+ 
Sbjct: 278 ISVSGATYKSMEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYLEDKTSLP 337

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVYSD+QARFLSEYRFD+SKLEPLVAKPHSPD  ALARECKDVKIDRVYIGSCTGGKT
Sbjct: 338 YEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDKCALARECKDVKIDRVYIGSCTGGKT 397

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAAK+F ASGK VKVPT
Sbjct: 398 EDFLAAAKVFHASGKKVKVPT 418

[14][TOP]
>UniRef100_C4IZQ5 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4IZQ5_MAIZE
          Length = 505

 Score =  258 bits (660), Expect = 1e-67
 Identities = 125/141 (88%), Positives = 135/141 (95%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATYKSMEFVG+TVESLTMEERMTLCNMVVEAGGKNGVVPAD TT+KYLEG+TSV 
Sbjct: 258 ISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYLEGRTSVD 317

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+PVYSD +ARF S+YRFDVSKLEP+VAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 318 YQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 377

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AA K+FLASGK VKVPT
Sbjct: 378 EDFLAAVKVFLASGKKVKVPT 398

[15][TOP]
>UniRef100_Q94AR8 3-isopropylmalate dehydratase n=1 Tax=Arabidopsis thaliana
           RepID=LEUC_ARATH
          Length = 509

 Score =  240 bits (612), Expect = 4e-62
 Identities = 115/141 (81%), Positives = 130/141 (92%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISVAGATYK+MEF GTT+ESL+MEERMTLCNMVVEAGGKNGV+P D+TT  Y+E +TSV 
Sbjct: 262 ISVAGATYKTMEFSGTTIESLSMEERMTLCNMVVEAGGKNGVIPPDATTLNYVENRTSVP 321

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +EPVYSD  A F+++YRFDVSKLEP+VAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT
Sbjct: 322 FEPVYSDGNASFVADYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 381

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDFMAAAK+F A+G+ VKVPT
Sbjct: 382 EDFMAAAKLFHAAGRKVKVPT 402

[16][TOP]
>UniRef100_B8LQY6 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQY6_PICSI
          Length = 515

 Score =  231 bits (590), Expect = 1e-59
 Identities = 110/141 (78%), Positives = 129/141 (91%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+V+G TY++MEF G+TV+SLTME+RMTLCNMVVEAGGKNGVV AD TT+ YLEGKTS +
Sbjct: 269 ITVSGGTYRAMEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVAADQTTFDYLEGKTSSS 328

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E +YSD+ AR+L EYRFDVSKLEPLVAKPHSPDNRALAREC+ +KIDRVYIGSCTGGKT
Sbjct: 329 FEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKT 388

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDFMAAAKI +++G+ VKVPT
Sbjct: 389 EDFMAAAKILISAGQKVKVPT 409

[17][TOP]
>UniRef100_B8LQ24 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQ24_PICSI
          Length = 516

 Score =  231 bits (588), Expect = 2e-59
 Identities = 110/141 (78%), Positives = 129/141 (91%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+V+GATY++MEF G+TV+SLTME+RMTLCNMVVEAGGKNGVV AD  T+ YLEGKTS +
Sbjct: 270 ITVSGATYRAMEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVDADQITFDYLEGKTSSS 329

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E +YSD+ AR+L EYRFDVSKLEPLVAKPHSPDNRALAREC+ +KIDRVYIGSCTGGKT
Sbjct: 330 FEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKT 389

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDFMAAAKI +++G+ VKVPT
Sbjct: 390 EDFMAAAKIMISAGQKVKVPT 410

[18][TOP]
>UniRef100_A9TGU1 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9TGU1_PHYPA
          Length = 518

 Score =  231 bits (588), Expect = 2e-59
 Identities = 113/141 (80%), Positives = 125/141 (88%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISVAGATY++MEFVGT V+++TME+RMTLCNMVVEAGGKNGVVPAD+TT KYLEGKTS  
Sbjct: 272 ISVAGATYRAMEFVGTAVDAMTMEDRMTLCNMVVEAGGKNGVVPADATTAKYLEGKTSKP 331

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   SD  A FL EYRFDVSKLEPLVAKPHSPDNR LARECKDVKIDRVYIGSCTGGKT
Sbjct: 332 YQVFTSDGNASFLQEYRFDVSKLEPLVAKPHSPDNRGLARECKDVKIDRVYIGSCTGGKT 391

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAA++   SG+ VKVPT
Sbjct: 392 EDFLAAAELLAISGQKVKVPT 412

[19][TOP]
>UniRef100_B9SQS6 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS6_RICCO
          Length = 621

 Score =  229 bits (583), Expect = 9e-59
 Identities = 110/121 (90%), Positives = 116/121 (95%)
 Frame = +1

Query: 61  LTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPVYSDQQARFLSEYRFDV 240
           L MEERMTLCNMV+EAGGKNGV+PADSTT+KYLE KTSV YEPVYSD+QARFLSEYRFD+
Sbjct: 394 LQMEERMTLCNMVIEAGGKNGVIPADSTTFKYLEDKTSVPYEPVYSDEQARFLSEYRFDI 453

Query: 241 SKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFMAAAKIFLASGKTVKVP 420
           SKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDF AAAK+FLASGK VKVP
Sbjct: 454 SKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFTAAAKVFLASGKKVKVP 513

Query: 421 T 423
           T
Sbjct: 514 T 514

[20][TOP]
>UniRef100_C0PRG9 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=C0PRG9_PICSI
          Length = 237

 Score =  219 bits (559), Expect = 6e-56
 Identities = 105/131 (80%), Positives = 120/131 (91%)
 Frame = +1

Query: 31  MEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPVYSDQQA 210
           MEF G+TV+SLTME+RMTLCNMVVEAGGKNGVV AD TT+ YLEGKTS ++E +YSD+ A
Sbjct: 1   MEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVAADQTTFDYLEGKTSSSFEALYSDEAA 60

Query: 211 RFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFMAAAKIF 390
           R+L EYRFDVSKLEPLVAKPHSPDNRALAREC+ +KIDRVYIGSCTGGKTEDFMAAAKI 
Sbjct: 61  RYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKTEDFMAAAKIL 120

Query: 391 LASGKTVKVPT 423
           +++G+ VKVPT
Sbjct: 121 ISAGQKVKVPT 131

[21][TOP]
>UniRef100_A8JG03 Isopropylmalate dehydratase, large subunit n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8JG03_CHLRE
          Length = 487

 Score =  209 bits (531), Expect = 1e-52
 Identities = 96/141 (68%), Positives = 119/141 (84%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISVAGATYK+MEF G+ +E + M+ERMT+CNMVVEAGGKNGV+  D TT+ Y++ +T  A
Sbjct: 241 ISVAGATYKAMEFAGSAIEGMNMDERMTICNMVVEAGGKNGVIAPDQTTFDYVKARTQEA 300

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +EPVYSD  A ++++Y++DVSKLEPLVA PHSPDNR  AREC DVKIDRVYIGSCTGGKT
Sbjct: 301 FEPVYSDGAASYIADYKWDVSKLEPLVAAPHSPDNRKTARECSDVKIDRVYIGSCTGGKT 360

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF++AAK+F  + + VKVPT
Sbjct: 361 EDFISAAKLFYRAKRQVKVPT 381

[22][TOP]
>UniRef100_Q111B2 Homoaconitate hydratase family protein n=1 Tax=Trichodesmium
           erythraeum IMS101 RepID=Q111B2_TRIEI
          Length = 439

 Score =  192 bits (487), Expect = 1e-47
 Identities = 93/141 (65%), Positives = 111/141 (78%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV+GATY++MEF G TV  +TMEERMTLCNMV+EAGGKNGV+  D  T++YL G+T   
Sbjct: 198 ISVSGATYRTMEFAGETVGQMTMEERMTLCNMVIEAGGKNGVIAPDEMTFEYLRGRTDKP 257

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E  YSD+ A F S+  +DV+KLEP+VAKPHSPDN+ LAR C+DVKIDRVYIGSCTGGKT
Sbjct: 258 FESFYSDKNAEFYSDRSYDVTKLEPVVAKPHSPDNKELARNCQDVKIDRVYIGSCTGGKT 317

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF+ AAK  L     VKVPT
Sbjct: 318 SDFLHAAK--LIKDHQVKVPT 336

[23][TOP]
>UniRef100_C1ZRL8 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Rhodothermus marinus
           DSM 4252 RepID=C1ZRL8_RHOMR
          Length = 432

 Score =  157 bits (397), Expect = 3e-37
 Identities = 77/141 (54%), Positives = 99/141 (70%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I + GATY++MEF G  V  L++EERMTL NM +EAGGK+G++  D  T  Y+  +T   
Sbjct: 191 IGIDGATYRAMEFDGEAVYDLSIEERMTLTNMAIEAGGKSGIIAPDEKTIAYVRERTDAP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E  +SD  AR+ SEY +DVSKLEP+VAKPH PDNRA   E    K+DR YIGSCTGGK 
Sbjct: 251 FEIYHSDPDARYHSEYVYDVSKLEPVVAKPHRPDNRATVTEVAGTKLDRAYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           EDF+AAA+I    G+ V++ T
Sbjct: 311 EDFIAAARIL--KGQEVRIDT 329

[24][TOP]
>UniRef100_UPI00016C35D3 homoaconitate hydratase family protein n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C35D3
          Length = 435

 Score =  155 bits (392), Expect = 1e-36
 Identities = 80/143 (55%), Positives = 101/143 (70%), Gaps = 2/143 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSV- 177
           I V GATY++MEF G  V +L +EERMTLCNM +EAGGKNG++ AD  T  Y+  + +  
Sbjct: 192 IGVDGATYRAMEFDGDGVYALNIEERMTLCNMAIEAGGKNGIIAADQVTLDYVNKRNAGN 251

Query: 178 -AYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
             Y  V SD  A+F+ E  +DVSKLEP++AKPHSPDN+A   + K  K+DR YIGSCTGG
Sbjct: 252 RPYTVVKSDPGAQFVFEKVYDVSKLEPVIAKPHSPDNKAFVSQVKGTKLDRAYIGSCTGG 311

Query: 355 KTEDFMAAAKIFLASGKTVKVPT 423
           K  DF AAA+  L +GKTVK+ T
Sbjct: 312 KLTDFKAAAQ--LLNGKTVKIDT 332

[25][TOP]
>UniRef100_B3EHN8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium limicola
           DSM 245 RepID=B3EHN8_CHLL2
          Length = 431

 Score =  153 bits (387), Expect = 5e-36
 Identities = 78/141 (55%), Positives = 96/141 (68%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY++MEF G  V SL ++ERMTLCNM +EAGG NG++ AD+ T  Y++  +S  
Sbjct: 191 IGTDGATYRAMEFDGEAVYSLPVDERMTLCNMAIEAGGMNGIIAADAVTEAYVKAHSSKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A + S YR++  +LEP+VAKPHSPDNRA  R  +  KI + YIGSCTGGK 
Sbjct: 251 YEIFQSDPDADYHSVYRYNARELEPVVAKPHSPDNRATVRSMQGTKITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DFM AAKI    GK V VPT
Sbjct: 311 TDFMLAAKIL--KGKQVTVPT 329

[26][TOP]
>UniRef100_C4C1N1 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Sebaldella termitidis
           ATCC 33386 RepID=C4C1N1_9FUSO
          Length = 435

 Score =  150 bits (379), Expect = 4e-35
 Identities = 71/141 (50%), Positives = 97/141 (68%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATYK M+F G  +    MEERMT+CNM +EAGGK G++  D  T +Y+  KT   
Sbjct: 191 IGFDGATYKCMQFDGDAIHGFNMEERMTICNMAIEAGGKCGIIEPDEITVEYVTEKTDKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E +YSD+ A + +EY+++ +++EP+VAKP +P N  LA+   DVK+DR YIGSCTGGKT
Sbjct: 251 FELIYSDKDADYSAEYKYNANEMEPIVAKPFNPGNTDLAKNLGDVKLDRAYIGSCTGGKT 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF+AAAKI    G+ V + T
Sbjct: 311 TDFVAAAKIL--KGRKVAIET 329

[27][TOP]
>UniRef100_B3QSN7 Homoaconitate hydratase family protein n=1 Tax=Chloroherpeton
           thalassium ATCC 35110 RepID=B3QSN7_CHLT3
          Length = 431

 Score =  150 bits (378), Expect = 5e-35
 Identities = 71/141 (50%), Positives = 97/141 (68%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  GATY++MEF G  + SL ++ERMTL NM +EAGG +G++ AD  T  +++ +TS  
Sbjct: 191 ITTDGATYRAMEFAGEAIHSLPIDERMTLTNMAIEAGGMSGIIAADEITEAFVKARTSAP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE  +SD  A++ S Y ++V +LEP+VAKPHSPDNR   R     K+ + Y+GSCTGGK 
Sbjct: 251 YEIFHSDPDAKYFSTYHYNVEELEPVVAKPHSPDNRDTVRNVAGTKLTKCYLGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF  AAK+    G+TVKVPT
Sbjct: 311 TDFEFAAKVL--HGQTVKVPT 329

[28][TOP]
>UniRef100_A4SFC8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeovibrioides DSM 265 RepID=A4SFC8_PROVI
          Length = 431

 Score =  150 bits (378), Expect = 5e-35
 Identities = 76/141 (53%), Positives = 94/141 (66%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY++MEF G  + SL MEERMTL NM +E GG NG++  D  T  +++ KTS  
Sbjct: 191 IGTDGATYRAMEFNGEAIHSLPMEERMTLTNMAIEGGGMNGIIAVDEITEAFVKSKTSKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A + S+ R++ S++EP+VAKPHSPDNRA  +  K  KI + YIGSCTGGK 
Sbjct: 251 YEIFTSDPGAAYFSKTRYNASEMEPVVAKPHSPDNRATVQSMKGTKITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF  AAKI   SGK V VPT
Sbjct: 311 ADFKLAAKIL--SGKRVSVPT 329

[29][TOP]
>UniRef100_A1BES2 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides DSM 266 RepID=A1BES2_CHLPD
          Length = 431

 Score =  150 bits (378), Expect = 5e-35
 Identities = 78/141 (55%), Positives = 94/141 (66%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY++MEF G  V SL +EERMTL NM +EAGG NG++ AD+ T  Y+  +T   
Sbjct: 191 IGTDGATYRAMEFDGEAVFSLPIEERMTLTNMAIEAGGMNGIIAADAITEAYVNARTQKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  AR+ S Y ++V +LEP+VA PHSPDNRA  R  +   I R YIGSCTGGK 
Sbjct: 251 YELFRSDPDARYHSSYTYNVRELEPVVACPHSPDNRATVRSVQGTAITRSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DFM AAKI   +GK V VPT
Sbjct: 311 SDFMMAAKIL--NGKKVSVPT 329

[30][TOP]
>UniRef100_B3QM97 Homoaconitate hydratase family protein n=1 Tax=Chlorobaculum parvum
           NCIB 8327 RepID=B3QM97_CHLP8
          Length = 431

 Score =  149 bits (376), Expect = 9e-35
 Identities = 76/141 (53%), Positives = 95/141 (67%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY++MEF G  V SL ++ERMTLCNM +EAGG NG++ AD+ T  +++ +TS  
Sbjct: 191 IGTDGATYRAMEFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVTEAFVKARTSKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A++ S YR++V KLEP+VA+PHSPDNRA  R      I + YIGSCTGGK 
Sbjct: 251 YEIFQSDPDAQYHSMYRYNVEKLEPVVAQPHSPDNRATVRSVAGTPITKSYIGSCTGGKI 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF  AAKI    GK V V T
Sbjct: 311 TDFRLAAKIL--KGKKVAVTT 329

[31][TOP]
>UniRef100_B4SDL0 Homoaconitate hydratase family protein n=1 Tax=Pelodictyon
           phaeoclathratiforme BU-1 RepID=B4SDL0_PELPB
          Length = 431

 Score =  149 bits (375), Expect = 1e-34
 Identities = 77/141 (54%), Positives = 94/141 (66%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  GATY +MEF G  + SL MEERMTL NM +EAGG NG++ ADS    Y++ ++   
Sbjct: 191 ITTDGATYCAMEFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADSIAENYVKARSQKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  AR+ S+YR+DV  LEP+VA+PHSPDNRA  R  +  KI + YIGSCTGGK 
Sbjct: 251 YELFQSDPDARYHSKYRYDVRTLEPVVAQPHSPDNRATVRSVQGTKITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DFM AAKI    G  V V T
Sbjct: 311 TDFMMAAKIL--KGHKVSVTT 329

[32][TOP]
>UniRef100_Q8KER8 3-isopropylmalate dehydratase, large subunit, putative n=1
           Tax=Chlorobaculum tepidum RepID=Q8KER8_CHLTE
          Length = 431

 Score =  148 bits (374), Expect = 2e-34
 Identities = 75/141 (53%), Positives = 95/141 (67%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  GATY++MEF G  V SL ++ERMTLCNM +EAGG NG++ AD+ T  +++ +TS  
Sbjct: 191 ITTDGATYRAMEFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVTEAFVKARTSKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A++ S YR++V K+EP+VAKPHSPDNRA         I + YIGSCTGGK 
Sbjct: 251 YEIFTSDPDAQYHSMYRYNVEKMEPIVAKPHSPDNRATVHSVAGTPITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF  AAKI    GK V V T
Sbjct: 311 TDFKLAAKIL--KGKKVAVTT 329

[33][TOP]
>UniRef100_Q3APC5 3-isopropylmalate dehydratase n=1 Tax=Chlorobium chlorochromatii
           CaD3 RepID=Q3APC5_CHLCH
          Length = 431

 Score =  147 bits (372), Expect = 3e-34
 Identities = 75/141 (53%), Positives = 95/141 (67%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  GATY++MEF G  + SL MEERMTL NM +EAGG NG++ AD+   +Y++ +T   
Sbjct: 191 ITTDGATYRAMEFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADNIAEEYVKARTKKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A++ S YR++V  LEP+VA+PHSPDNRA  R     KI + YIGSCTGGK 
Sbjct: 251 YEIFQSDPDAKYHSTYRYNVRDLEPVVAQPHSPDNRATVRSVAGTKITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DFM AAKI    G+ V V T
Sbjct: 311 SDFMMAAKIL--KGQKVTVTT 329

[34][TOP]
>UniRef100_Q0YQD5 Homoaconitate hydratase family protein:3-isopropylmalate
           dehydratase, prokaryotic n=1 Tax=Chlorobium ferrooxidans
           DSM 13031 RepID=Q0YQD5_9CHLB
          Length = 431

 Score =  147 bits (372), Expect = 3e-34
 Identities = 75/141 (53%), Positives = 94/141 (66%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  GATYK+MEF G  + SL MEERMTL NM +EAGG NG++ ADS    Y+  ++   
Sbjct: 191 ITTDGATYKAMEFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADSVAESYVRARSQKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A++ S Y ++V +LEP+VA+PHSPDNRA  R  +  KI + YIGSCTGGK 
Sbjct: 251 YEIFRSDPDAKYHSRYHYNVRELEPVVAQPHSPDNRATVRSVQGTKITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF+ AAKI    GK V V T
Sbjct: 311 TDFVMAAKIL--KGKKVSVTT 329

[35][TOP]
>UniRef100_Q3B597 3-isopropylmalate dehydratase n=1 Tax=Chlorobium luteolum DSM 273
           RepID=Q3B597_PELLD
          Length = 431

 Score =  147 bits (371), Expect = 4e-34
 Identities = 73/141 (51%), Positives = 95/141 (67%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY+++EF G  + SL MEERMTL NM +EAGG NG++  D  T  +++ +T+ +
Sbjct: 191 IGTDGATYRALEFDGDAIHSLPMEERMTLTNMAIEAGGMNGIIAVDEITEAFVKARTTKS 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE  +SD  A++ S YR+D SKLEP+VAKPHSPDNRA  R      I + YIGSCTGGK 
Sbjct: 251 YEIFHSDPDAKYHSLYRYDASKLEPVVAKPHSPDNRATVRSVAGTPITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF  AA+I   +G+ V V T
Sbjct: 311 TDFKMAARIL--NGRKVAVTT 329

[36][TOP]
>UniRef100_B3EKV4 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides BS1 RepID=B3EKV4_CHLPB
          Length = 432

 Score =  144 bits (364), Expect = 2e-33
 Identities = 75/141 (53%), Positives = 95/141 (67%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           IS  GATY++MEF G+ V SL MEERMTL NM +EAGG +G++ ADS T  Y++ ++   
Sbjct: 191 ISTDGATYRAMEFDGSAVFSLPMEERMTLTNMAIEAGGMSGIIAADSITEAYVKERSDKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A + S +R+   +LEP+VA PHSPDNRA  R  +  KI + YIGSCTGGK 
Sbjct: 251 YEIFTSDPDALYHSIHRYKTEELEPVVAMPHSPDNRATVRSVQGTKITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF+ AAK+    G TV VPT
Sbjct: 311 IDFVMAAKVL--KGNTVSVPT 329

[37][TOP]
>UniRef100_B4S6N0 Homoaconitate hydratase family protein n=1 Tax=Prosthecochloris
           aestuarii DSM 271 RepID=B4S6N0_PROA2
          Length = 432

 Score =  144 bits (362), Expect = 4e-33
 Identities = 72/141 (51%), Positives = 95/141 (67%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY++MEF G+ V  L +EERMTL NM +EAGG NG++ AD  T  Y++ +TS  
Sbjct: 191 IGTDGATYRAMEFDGSAVYQLPVEERMTLTNMAIEAGGMNGIIAADEVTEAYVKARTSKP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE  +SD  A + S Y ++V +LEP+VA+PHSPDNRA  R  +  +I + YIGSCTGGK 
Sbjct: 251 YEIFHSDPDAIYHSIYHYNVEELEPVVAQPHSPDNRATVRSVQGTRITKSYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF  AAKI   +G+ V + T
Sbjct: 311 SDFKMAAKIL--NGQQVSIQT 329

[38][TOP]
>UniRef100_B2VKF3 3-isopropylmalate dehydratase large subunit n=1 Tax=Erwinia
           tasmaniensis RepID=B2VKF3_ERWT9
          Length = 436

 Score =  136 bits (342), Expect = 8e-31
 Identities = 65/141 (46%), Positives = 96/141 (68%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ++V GATY+++EF G+ ++++++EERMT+CNMVVE G KNG++  +  T  YL  +T + 
Sbjct: 191 LTVDGATYEAIEFGGSVIDAMSVEERMTICNMVVECGAKNGIMVPNQATLDYLATRTDIP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +  V  D  AR+      +V++++PLVAKPHSPDN       K+V I + YIGSCTGGK 
Sbjct: 251 FSVVEPDADARYSQVLDINVTEMQPLVAKPHSPDNVVAIDTLKNVAISQAYIGSCTGGKL 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
            DF+AAA++    G+ V VPT
Sbjct: 311 ADFIAAARVI--KGRKVVVPT 329

[39][TOP]
>UniRef100_Q6B920 3-isopropylmalate dehydratase large subunit n=1 Tax=Gracilaria
           tenuistipitata var. liui RepID=Q6B920_GRATL
          Length = 439

 Score =  135 bits (340), Expect = 1e-30
 Identities = 60/130 (46%), Positives = 93/130 (71%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ++  GATY+S+EF G T++++++E+RMTLCNMV+EAG KNG++  +++T +Y+  ++ + 
Sbjct: 195 LTTQGATYQSIEFTGETIDNMSIEDRMTLCNMVIEAGAKNGIIIPNNSTIEYINARSDIK 254

Query: 181 -YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            ++ +  DQ A +     +DV+ ++P +AKPHSPDN       +  KIDR YIGSCTGGK
Sbjct: 255 DFDIIVPDQSAHYTKVLEYDVTNIQPQIAKPHSPDNVDSIDNVEGEKIDRAYIGSCTGGK 314

Query: 358 TEDFMAAAKI 387
           + DF AAAKI
Sbjct: 315 SSDFYAAAKI 324

[40][TOP]
>UniRef100_A9A5B7 3-isopropylmalate dehydratase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A5B7_NITMS
          Length = 422

 Score =  133 bits (334), Expect = 7e-30
 Identities = 64/141 (45%), Positives = 90/141 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   G  Y++M+F GT ++ +++E R+TLCNM  EAG KNG+  AD     YL  + +  
Sbjct: 191 IGTDGGNYRTMQFGGTGIDEMSVESRLTLCNMTTEAGAKNGIAEADQKVVDYLSSRGATN 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
            +    D  A++ + Y ++ S++EPLVAKP SP+N A+ RE   V++D+ YIGSCTG K 
Sbjct: 251 AQVFKGDDDAQYANVYEYEASEMEPLVAKPFSPENIAVVREAPSVELDKSYIGSCTGAKY 310

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED  AAAKI    GKTVK+ T
Sbjct: 311 EDLEAAAKIL--KGKTVKIRT 329

[41][TOP]
>UniRef100_Q8TLF1 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina acetivorans RepID=LEUC1_METAC
          Length = 424

 Score =  132 bits (332), Expect = 1e-29
 Identities = 62/139 (44%), Positives = 87/139 (62%)
 Frame = +1

Query: 7   VAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYE 186
           +AGATYK++EF G  +  LT+  RMTLCNM +E G K G+VP D  T+++L+ + +  YE
Sbjct: 196 IAGATYKAVEFYGQAIRELTVAGRMTLCNMAIEMGAKTGIVPPDEKTFEFLKNRAAATYE 255

Query: 187 PVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
           PVY+D  A +L E+ +D   +EP VA PH  DN     E +   +D+V+IG+CT G+ ED
Sbjct: 256 PVYADPDAVYLEEFTYDADDIEPQVACPHQVDNVKPVGEVEGTHVDQVFIGTCTNGRLED 315

Query: 367 FMAAAKIFLASGKTVKVPT 423
              AA +    GK V V T
Sbjct: 316 LEVAAAVL--KGKQVAVRT 332

[42][TOP]
>UniRef100_B0TCR2 3-isopropylmalate dehydratase large subunit n=1 Tax=Heliobacterium
           modesticaldum Ice1 RepID=LEUC_HELMI
          Length = 420

 Score =  130 bits (328), Expect = 3e-29
 Identities = 65/137 (47%), Positives = 88/137 (64%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G+ ++ L+M+ RMT+CNM +EAGGKNG++  D  T  Y+E + +  
Sbjct: 186 IGVDGALYQSMEFTGSAIDDLSMDGRMTMCNMAIEAGGKNGIIAPDKKTIAYVEERATRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   SD  A++    ++DV KLEP+VA PH P+N     E   V+ID+V IGSCT G+ 
Sbjct: 246 YKVYTSDPDAKYARVIKYDVEKLEPVVAFPHLPENTRPVSEAGHVEIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AAKI    GK V
Sbjct: 306 EDLRMAAKIL--QGKKV 320

[43][TOP]
>UniRef100_A5D4W1 3-isopropylmalate dehydratase large subunit n=1 Tax=Pelotomaculum
           thermopropionicum SI RepID=A5D4W1_PELTS
          Length = 420

 Score =  130 bits (327), Expect = 4e-29
 Identities = 62/129 (48%), Positives = 84/129 (65%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G  VE L+M+ R T+CNM VEAGGKNG++  D TT  Y+EG+    
Sbjct: 186 IGVDGALYKAMEFTGPAVEKLSMDGRFTMCNMAVEAGGKNGIIAPDETTRVYVEGRCKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  A++   YR+D +++EP VA PH P+N     E  +++ID+V IGSCT G+ 
Sbjct: 246 YRFYRSDPDAKYEKIYRYDAAQIEPQVAFPHLPENSRPVSEAGNIEIDQVVIGSCTNGRM 305

Query: 361 EDFMAAAKI 387
           ED   AA++
Sbjct: 306 EDLREAARV 314

[44][TOP]
>UniRef100_C9RAX0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ammonifex
           degensii KC4 RepID=C9RAX0_9THEO
          Length = 421

 Score =  130 bits (327), Expect = 4e-29
 Identities = 67/137 (48%), Positives = 84/137 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y +MEF G  +E L+M+ R T+CNM VEAG KNG++  D  T  YLEG+    
Sbjct: 185 IGVEGALYCAMEFTGPVIEELSMDGRFTMCNMAVEAGAKNGIIAPDEKTAAYLEGRARRP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   SD  AR+ + Y FDVS+LEP VA PHSP N     E   + ID+V IGSCT G+ 
Sbjct: 245 YKFFQSDPDARYQAVYEFDVSRLEPQVALPHSPANTRPVTEVTHITIDQVVIGSCTNGRL 304

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA++    GK V
Sbjct: 305 EDLRVAAQVL--KGKKV 319

[45][TOP]
>UniRef100_A6DRT0 3-isopropylmalate dehydratase n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DRT0_9BACT
          Length = 433

 Score =  130 bits (327), Expect = 4e-29
 Identities = 64/129 (49%), Positives = 84/129 (65%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I  +GATY +MEF G  ++ L++EERMT+CNM +EAGGKNGV+ AD+    Y++ +T V 
Sbjct: 191 IGFSGATYCAMEFEGPVIDELSIEERMTICNMAIEAGGKNGVIAADAKVEAYVKERTDVP 250

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D  A +   Y  + S+LEP VA P +PD R    E     + R YIGSCTGGKT
Sbjct: 251 YTLFKADADADYKDVYEINCSELEPTVAIPSAPDKRKGVSEIAGTDLTRAYIGSCTGGKT 310

Query: 361 EDFMAAAKI 387
           EDF AAA+I
Sbjct: 311 EDFAAAAEI 319

[46][TOP]
>UniRef100_Q12TV2 Homoaconitase large subunit n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=Q12TV2_METBU
          Length = 413

 Score =  130 bits (326), Expect = 6e-29
 Identities = 63/141 (44%), Positives = 88/141 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           +  +GATYK+ EF G T+  L++  RMTL NM +E G K G+VP D  T+ +LEG+    
Sbjct: 183 VGASGATYKAAEFYGDTITDLSISGRMTLSNMAIEMGAKAGIVPPDQKTFDFLEGRAVEG 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPVY+D+ A + +EY  D + LEP +A PH  DN     E +  K+D+V+IG+CT G+ 
Sbjct: 243 YEPVYADEDAEYCAEYDIDGANLEPQIALPHQVDNVCDVSEIEGKKVDQVFIGTCTNGRL 302

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED   AA+I    G+ V V T
Sbjct: 303 EDLEVAAEIL--KGEQVAVRT 321

[47][TOP]
>UniRef100_Q8PZT3 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina mazei RepID=LEUC1_METMA
          Length = 391

 Score =  130 bits (326), Expect = 6e-29
 Identities = 62/139 (44%), Positives = 85/139 (61%)
 Frame = +1

Query: 7   VAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYE 186
           +AGATYK++EF G  +  L++  RMTLCNM +E G K G+VP D  T+ +L+ +    YE
Sbjct: 163 IAGATYKAVEFYGQAISELSVAGRMTLCNMAIEMGAKTGIVPPDEKTFDFLKNRAVAPYE 222

Query: 187 PVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
           PVYSD  A +L E+ +D   +EP VA PH  DN     E +   +D+V+IG+CT G+ ED
Sbjct: 223 PVYSDPDASYLKEFVYDAGDIEPQVACPHQVDNVKPVGEVEGTHVDQVFIGTCTNGRLED 282

Query: 367 FMAAAKIFLASGKTVKVPT 423
              AA +    GK V V T
Sbjct: 283 LEVAASVL--KGKKVTVRT 299

[48][TOP]
>UniRef100_B8CX22 3-isopropylmalate dehydratase large subunit n=1 Tax=Halothermothrix
           orenii H 168 RepID=LEUC_HALOH
          Length = 420

 Score =  129 bits (325), Expect = 8e-29
 Identities = 63/129 (48%), Positives = 82/129 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G T+E+L+M+ RMT+ NM +EAGGK G++  D  T+KYLE +    
Sbjct: 186 IGVDGALYRAMEFTGETIENLSMDNRMTISNMAIEAGGKCGLIAPDEKTFKYLENRAQRD 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y P YSD  A +     +DVS +EP VA PH P+N     E  D+KID+  IGSCT G+ 
Sbjct: 246 YTPCYSDDDAEYEKVIEYDVSDIEPQVAFPHLPENTRPISEEGDIKIDQAVIGSCTNGRM 305

Query: 361 EDFMAAAKI 387
           ED   AA I
Sbjct: 306 EDLRIAAGI 314

[49][TOP]
>UniRef100_B4D0Q5 Aconitate hydratase domain protein n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0Q5_9BACT
          Length = 456

 Score =  129 bits (324), Expect = 1e-28
 Identities = 67/146 (45%), Positives = 91/146 (62%), Gaps = 5/146 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYL-----EG 165
           I   GATY++M++ G  V  ++M++RMT+ NM +EAGGKNG+ P D  T  Y+     E 
Sbjct: 209 IGFDGATYRAMQWEGPGVYGMSMDDRMTIANMAIEAGGKNGIFPFDEKTDAYVKDRVQEN 268

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   +EP   DQ  +F+ +  FD+SKLEP VA    P  R  A+E   V +DR YIGSC
Sbjct: 269 GTKSTFEPAEIDQDQKFIYDKVFDLSKLEPTVACHPDPGQRKTAKELAGVSLDRAYIGSC 328

Query: 346 TGGKTEDFMAAAKIFLASGKTVKVPT 423
           TGGKT DF+A A++    GK+VK+ T
Sbjct: 329 TGGKTSDFLAFARV--VKGKSVKIDT 352

[50][TOP]
>UniRef100_A0RXN9 3-isopropylmalate dehydratase large subunit n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RXN9_CENSY
          Length = 429

 Score =  129 bits (323), Expect = 1e-28
 Identities = 59/137 (43%), Positives = 89/137 (64%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           G  Y++M+F GT +  +++E R+TL NM  EAG KNG++ AD  T  YL  + +   +PV
Sbjct: 201 GGAYRTMQFAGTGITEMSVEGRLTLANMTTEAGAKNGIIEADKKTAGYLSSRGATGIKPV 260

Query: 193 YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFM 372
             D  A +   + ++ S++EPLVAKP+SP+N ++ RE   V++D+ YIGSCTG K ED  
Sbjct: 261 IGDDDAEYSEVFEYEGSEMEPLVAKPYSPENVSIVREAPSVELDKAYIGSCTGAKMEDLE 320

Query: 373 AAAKIFLASGKTVKVPT 423
           AAA+I    G+ V++ T
Sbjct: 321 AAARIL--KGRKVRIRT 335

[51][TOP]
>UniRef100_C4FRW1 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC
           17748 RepID=C4FRW1_9FIRM
          Length = 419

 Score =  128 bits (322), Expect = 2e-28
 Identities = 63/131 (48%), Positives = 87/131 (66%), Gaps = 1/131 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y ++EF G  V+ +TM +R+T+CNM +EAGGK GV P D+ T +Y++G+ +  
Sbjct: 185 IGVDGARYMALEFAGDGVQHMTMADRLTICNMAIEAGGKCGVFPYDAVTEEYIKGRVNRP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC-KDVKIDRVYIGSCTGGK 357
            EP+  D  A +      D+SKL+P+VA PH P N     E  KD+KID+V IGSCT G+
Sbjct: 245 VEPIAPDADAVYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKDIKIDQVIIGSCTNGR 304

Query: 358 TEDFMAAAKIF 390
            ED +AAA+IF
Sbjct: 305 YEDLVAAAEIF 315

[52][TOP]
>UniRef100_B3E0P6 3-isopropylmalate dehydratase large subunit n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3E0P6_METI4
          Length = 455

 Score =  128 bits (321), Expect = 2e-28
 Identities = 69/146 (47%), Positives = 88/146 (60%), Gaps = 5/146 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTY-----KYLEG 165
           I   GATY +M+F G  V +L +E+RMT+ NM +EAG KNG+ PAD  T      K L+ 
Sbjct: 209 IGFDGATYMAMQFEGPGVSTLEIEDRMTVANMAIEAGAKNGIFPADQKTIDFVRQKVLKN 268

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   +E V  D+   F + Y  D+S +EP VA PH+P NR  A+E   VKIDR Y+GSC
Sbjct: 269 GTKKEFEVVDPDKDQHFFASYFIDLSLVEPTVAAPHNPGNRMKAKELGSVKIDRAYLGSC 328

Query: 346 TGGKTEDFMAAAKIFLASGKTVKVPT 423
           TGGK  DF+A A I     +TV V T
Sbjct: 329 TGGKLSDFIAFASIL--KNRTVSVET 352

[53][TOP]
>UniRef100_C0V4R3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Veillonella
           parvula DSM 2008 RepID=C0V4R3_9FIRM
          Length = 419

 Score =  128 bits (321), Expect = 2e-28
 Identities = 63/131 (48%), Positives = 87/131 (66%), Gaps = 1/131 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y ++EF G  V+ +TM +R+T+CNM +EAGGK GV P D+ T +Y++G+ +  
Sbjct: 185 IGVDGARYMALEFAGEGVQHMTMADRLTICNMAIEAGGKCGVFPYDAITEEYIKGRVNRP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC-KDVKIDRVYIGSCTGGK 357
            EP+  D  A +      D+SKL+P+VA PH P N     E  KD+KID+V IGSCT G+
Sbjct: 245 VEPIAPDADAVYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKDIKIDQVIIGSCTNGR 304

Query: 358 TEDFMAAAKIF 390
            ED +AAA+IF
Sbjct: 305 YEDLVAAAEIF 315

[54][TOP]
>UniRef100_A5AN38 Putative uncharacterized protein n=1 Tax=Vitis vinifera
           RepID=A5AN38_VITVI
          Length = 252

 Score =  128 bits (321), Expect = 2e-28
 Identities = 67/90 (74%), Positives = 69/90 (76%), Gaps = 15/90 (16%)
 Frame = +1

Query: 199 DQQARFLSEYRFDVSKLEPLVAK---------------PHSPDNRALARECKDVKIDRVY 333
           D   RFLSEYRFDVSKLEPLVAK               PHSPDNRALARECKDVKIDRVY
Sbjct: 23  DSVHRFLSEYRFDVSKLEPLVAKVRDFYMALSEIIFIFPHSPDNRALARECKDVKIDRVY 82

Query: 334 IGSCTGGKTEDFMAAAKIFLASGKTVKVPT 423
           IGSCTGGKTEDF+AAAK+F  SGK VKVPT
Sbjct: 83  IGSCTGGKTEDFLAAAKVFHVSGKKVKVPT 112

[55][TOP]
>UniRef100_UPI0001966B48 hypothetical protein SUBVAR_01587 n=1 Tax=Subdoligranulum variabile
           DSM 15176 RepID=UPI0001966B48
          Length = 419

 Score =  127 bits (320), Expect = 3e-28
 Identities = 61/129 (47%), Positives = 84/129 (65%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V+GA YKS+EF G  V+SLTME+R+ +CNM +EAG KNG+ P D     YL+G++   
Sbjct: 186 IGVSGALYKSLEFTGDGVKSLTMEDRLCICNMAIEAGAKNGIFPVDEICEAYLKGRSQRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +    +D  A +      D+  LEP V+ PH P+N  LA+E KD+KID++ IGSCT G+ 
Sbjct: 246 WVKYEADPDAEYERTVIIDLDTLEPTVSYPHLPENTHLAKEGKDIKIDQIVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED  AA +I
Sbjct: 306 EDMQAAYEI 314

[56][TOP]
>UniRef100_A4J182 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum reducens MI-1 RepID=A4J182_DESRM
          Length = 418

 Score =  127 bits (319), Expect = 4e-28
 Identities = 64/137 (46%), Positives = 84/137 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G  +  L+M+ R T+CNM +EAGGKNG++  D  T +Y+EG+T   
Sbjct: 184 IGVDGALYKAMEFCGEAISQLSMDGRFTMCNMAIEAGGKNGIIQPDEITRQYVEGRTKRP 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  A++   Y FDV+K+EP VA PH P+N     +   V ID+  IGSCT G+ 
Sbjct: 244 YTFYTSDPDAQYSKVYEFDVNKIEPQVAFPHLPENARPVSQAGHVDIDQAVIGSCTNGRM 303

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA+I    GK V
Sbjct: 304 EDLRLAAEIL--KGKKV 318

[57][TOP]
>UniRef100_B5ICW8 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5ICW8_9EURY
          Length = 419

 Score =  127 bits (319), Expect = 4e-28
 Identities = 65/132 (49%), Positives = 85/132 (64%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK-TSV 177
           I   GATYKSMEF G T++ ++ME R T+ NM +EAGGK G++  D+TT KYLE      
Sbjct: 182 IGADGATYKSMEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYLEEMGRGE 241

Query: 178 AYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECK--DVKIDRVYIGSCTG 351
            Y  + SD  A F  EY F+V +LEP V+ PH+ DN     E K  +++ID+VYIG+CT 
Sbjct: 242 KYREIKSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKMNIRIDQVYIGTCTN 301

Query: 352 GKTEDFMAAAKI 387
           G+ ED   AAKI
Sbjct: 302 GRIEDLRVAAKI 313

[58][TOP]
>UniRef100_B5IBC4 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IBC4_9EURY
          Length = 419

 Score =  127 bits (318), Expect = 5e-28
 Identities = 65/132 (49%), Positives = 85/132 (64%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK-TSV 177
           I   GATYKSMEF G T++ ++ME R T+ NM +EAGGK G++  D+TT KYLE      
Sbjct: 182 IGADGATYKSMEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYLEEMGRGD 241

Query: 178 AYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECK--DVKIDRVYIGSCTG 351
            Y  + SD  A F  EY F+V +LEP V+ PH+ DN     E K  +++ID+VYIG+CT 
Sbjct: 242 KYREIKSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKMNIRIDQVYIGTCTN 301

Query: 352 GKTEDFMAAAKI 387
           G+ ED   AAKI
Sbjct: 302 GRIEDLRVAAKI 313

[59][TOP]
>UniRef100_Q2RG98 3-isopropylmalate dehydratase large subunit n=1 Tax=Moorella
           thermoacetica ATCC 39073 RepID=LEUC_MOOTA
          Length = 421

 Score =  127 bits (318), Expect = 5e-28
 Identities = 61/129 (47%), Positives = 80/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y +MEF G  + +L+ME R T+ NM +EAGGKNG+ P D  T +Y+ G+    
Sbjct: 186 IGVDGARYMAMEFTGEAITNLSMEGRFTMANMAIEAGGKNGIFPVDEKTVEYIRGRLQRD 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  AR+  E   D SK+EP VA PH P+N    +E  ++KID+V IGSCT G+ 
Sbjct: 246 YRIYQSDPDARYNQEIDIDASKIEPQVALPHLPENARSVKEIGEIKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
           ED   AA+I
Sbjct: 306 EDLRVAAQI 314

[60][TOP]
>UniRef100_B5YEF5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           thermophilum H-6-12 RepID=B5YEF5_DICT6
          Length = 424

 Score =  126 bits (316), Expect = 8e-28
 Identities = 60/130 (46%), Positives = 84/130 (64%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G  + +L M +R+T+CNM +EAG KNG++  D  T  Y+  +    
Sbjct: 186 IGVDGARYKAMEFTGEVIRNLPMSDRLTICNMAIEAGAKNGIIEPDEITLDYVRNRAKRD 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKDVKIDRVYIGSCTGGK 357
           ++   SD+ A++   Y +DVS LEP+VA PH P N + ++   KD+ ID+VYIGSCT G+
Sbjct: 246 FKIYKSDEDAQYKEVYEWDVSDLEPIVAFPHLPSNIKKISEISKDIYIDQVYIGSCTNGR 305

Query: 358 TEDFMAAAKI 387
            ED   AAKI
Sbjct: 306 IEDLRIAAKI 315

[61][TOP]
>UniRef100_C0FYL9 Putative uncharacterized protein n=1 Tax=Roseburia inulinivorans
           DSM 16841 RepID=C0FYL9_9FIRM
          Length = 436

 Score =  126 bits (316), Expect = 8e-28
 Identities = 64/138 (46%), Positives = 85/138 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +  LTM++R T+ NM +EAGGKNG+ P D    +Y+E  +   
Sbjct: 202 IGVDGALYKSMEFVGDGIRYLTMDDRFTIANMAIEAGGKNGIFPVDDLAKQYMEEHSKRP 261

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A + +EY  D+S L+P V+ PH P+N     E  DVKID+V IGSCT G+ 
Sbjct: 262 YVVYEADEDAEYDAEYTIDLSTLKPTVSFPHLPENTRTIDEVGDVKIDQVVIGSCTNGRM 321

Query: 361 EDFMAAAKIFLASGKTVK 414
           +D   AA +    GK VK
Sbjct: 322 DDLRIAASVL--KGKKVK 337

[62][TOP]
>UniRef100_Q3Z9A7 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides
           ethenogenes 195 RepID=Q3Z9A7_DEHE1
          Length = 417

 Score =  125 bits (315), Expect = 1e-27
 Identities = 62/131 (47%), Positives = 86/131 (65%), Gaps = 1/131 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATYK++EF G  V ++T+ ER+T+ NM VEAG K G+ P+D  T +YL      A
Sbjct: 182 IGADGATYKALEFSGNVVNNMTIAERLTIANMAVEAGAKVGLFPSDRQTLEYLRSVGREA 241

Query: 181 -YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            Y+P+ +D+ A +      D + LEP+VAKPH+ DN A ARE K  K+D+V+IG+CTGG+
Sbjct: 242 DYQPLAADEDAVYERVIEIDATALEPMVAKPHTVDNTATARELKGTKLDQVFIGTCTGGR 301

Query: 358 TEDFMAAAKIF 390
            +D   AA IF
Sbjct: 302 LDDLAVAAAIF 312

[63][TOP]
>UniRef100_C7H4B6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Faecalibacterium prausnitzii A2-165
           RepID=C7H4B6_9FIRM
          Length = 419

 Score =  125 bits (315), Expect = 1e-27
 Identities = 67/132 (50%), Positives = 82/132 (62%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG---KT 171
           I V GA YKSMEF G  V SLTME+R+ +CNM +EAG KNG+ P D  T  YL G   +T
Sbjct: 186 IGVDGALYKSMEFTGPGVASLTMEDRLCVCNMAIEAGAKNGIFPVDEVTRAYLNGRSQRT 245

Query: 172 SVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTG 351
            V YE   +D  A +      D+ KLEP V+ PH P+N   A E KD++ID+V IGSCT 
Sbjct: 246 PVYYE---ADPDAEYEKTIEIDLDKLEPTVSYPHLPENTHPASEGKDIRIDQVVIGSCTN 302

Query: 352 GKTEDFMAAAKI 387
           G+ ED  AA  I
Sbjct: 303 GRLEDMEAAYNI 314

[64][TOP]
>UniRef100_A6TTR7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Alkaliphilus
           metalliredigens QYMF RepID=A6TTR7_ALKMQ
          Length = 420

 Score =  125 bits (314), Expect = 1e-27
 Identities = 65/137 (47%), Positives = 84/137 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ LTM++R T+ NM +EAGGKNG+ P D  T +Y+   +   
Sbjct: 186 IGVDGALYKSMEFVGEGIKHLTMDDRFTMANMAIEAGGKNGIFPVDELTLEYVRVHSKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +   Y  D+S+L P VA PH PDN     E  DVKID+V IGSCT G+ 
Sbjct: 246 YTVYRADEDAVYEETYEIDLSRLLPTVAFPHIPDNIRTIDEVGDVKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
           +D   AAK+    GK V
Sbjct: 306 QDLRMAAKVM--EGKQV 320

[65][TOP]
>UniRef100_A8SZ55 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SZ55_9FIRM
          Length = 461

 Score =  125 bits (314), Expect = 1e-27
 Identities = 60/129 (46%), Positives = 85/129 (65%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +++LTM++R T+ NM +EAG KNG+ P D  T +Y++  ++ +
Sbjct: 226 IGVDGALYKSMEFVGEGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTEEYMKEHSTKS 285

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A + +EY  D+S+L+P VA PH P+N     E  D+KID+V IGSCT G+ 
Sbjct: 286 YTKYEADEDAVYDAEYTIDLSQLKPTVAFPHLPENTKTIDEVGDIKIDQVVIGSCTNGRI 345

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 346 SDMRIAADI 354

[66][TOP]
>UniRef100_A5ZAM9 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum
           ATCC 27560 RepID=A5ZAM9_9FIRM
          Length = 421

 Score =  125 bits (314), Expect = 1e-27
 Identities = 61/129 (47%), Positives = 82/129 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEFVG  ++ L+M++R  + NM +EAGGKNG+ P D  T +Y++  ++  
Sbjct: 186 IGVDGALYRSMEFVGDGIKYLSMDDRFAMTNMAIEAGGKNGIFPVDDLTIEYMKEHSTKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +  EY  D+S L P VA PH P+N     E  DVKID+V IGSCT G+ 
Sbjct: 246 YTVYEADEDAEYDEEYTIDLSTLRPTVAFPHLPENTRTIDEVGDVKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED   AAKI
Sbjct: 306 EDMRTAAKI 314

[67][TOP]
>UniRef100_B3TBB7 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8O8 RepID=B3TBB7_9ARCH
          Length = 423

 Score =  125 bits (314), Expect = 1e-27
 Identities = 61/141 (43%), Positives = 88/141 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  G    +M+F G  +  +++E R+TL NM  EAG KNG++  D   + YL  +    
Sbjct: 192 ITTEGGAGCAMQFGGDGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLAERGVTE 251

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+ VY D+ A++   Y +DVS+LEPLVAKP SP N ++ +E   ++ID+ YIGSCTG K 
Sbjct: 252 YDAVYDDEDAQYAKTYEYDVSELEPLVAKPFSPQNVSVVQETTGIEIDKSYIGSCTGAKY 311

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED +A A+I    G+ VKV T
Sbjct: 312 EDLVAVARIL--KGRKVKVRT 330

[68][TOP]
>UniRef100_B8E2X0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           turgidum DSM 6724 RepID=B8E2X0_DICTD
          Length = 424

 Score =  125 bits (313), Expect = 2e-27
 Identities = 59/130 (45%), Positives = 85/130 (65%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G  + +L+M +R+T+CNM +EAG KNG++  D  T +Y+  +    
Sbjct: 186 IGVDGARYKAMEFTGEVIRNLSMSDRLTICNMAIEAGAKNGIIEPDEITLEYVRNRAKRN 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKDVKIDRVYIGSCTGGK 357
           ++   SD+ A +   Y +DV+ LEP+VA PH P N + ++   KD+ ID+VYIGSCT G+
Sbjct: 246 FKVYKSDEDAHYKEIYEWDVTNLEPIVAFPHLPSNIKKISDIGKDIYIDQVYIGSCTNGR 305

Query: 358 TEDFMAAAKI 387
            ED   AAKI
Sbjct: 306 IEDLRLAAKI 315

[69][TOP]
>UniRef100_B3T8D2 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG5E24 RepID=B3T8D2_9ARCH
          Length = 423

 Score =  124 bits (312), Expect = 2e-27
 Identities = 60/141 (42%), Positives = 86/141 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  G    +M+F G  +  +++E R+TL NM  EAG KNG++  D   + YL  +    
Sbjct: 192 ITTEGGAGHAMQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLSERGVTE 251

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+ VY D  A++   Y +DV++LEPLVAKP SP N ++ +E   +++D+ YIGSCTG K 
Sbjct: 252 YDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIGSCTGAKY 311

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED  A AKI    GK VK+ T
Sbjct: 312 EDLEAVAKIL--KGKKVKIRT 330

[70][TOP]
>UniRef100_B3TAM8 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8G2 RepID=B3TAM8_9ARCH
          Length = 423

 Score =  124 bits (311), Expect = 3e-27
 Identities = 60/141 (42%), Positives = 86/141 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  G    +M+F G  +  +++E R+TL NM  EAG KNG++  D   + YL  +    
Sbjct: 192 ITTEGGAGYAMQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLSERGVTE 251

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+ VY D  A++   Y +DV++LEPLVAKP SP N ++ +E   +++D+ YIGSCTG K 
Sbjct: 252 YDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIGSCTGAKY 311

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED  A AKI    GK VK+ T
Sbjct: 312 EDLEAVAKIL--KGKKVKIRT 330

[71][TOP]
>UniRef100_B3T9D1 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG6J21 RepID=B3T9D1_9ARCH
          Length = 423

 Score =  124 bits (311), Expect = 3e-27
 Identities = 60/141 (42%), Positives = 86/141 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+  G    +M+F G  +  +++E R+TL NM  EAG KNG++  D   + YL  +    
Sbjct: 192 ITTEGGAGYAMQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLSERGVTE 251

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+ VY D  A++   Y +DV++LEPLVAKP SP N ++ +E   +++D+ YIGSCTG K 
Sbjct: 252 YDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIGSCTGAKY 311

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED  A AKI    GK VK+ T
Sbjct: 312 EDLEAVAKIL--KGKKVKIRT 330

[72][TOP]
>UniRef100_A7VIP8 Putative uncharacterized protein n=1 Tax=Clostridium sp. L2-50
           RepID=A7VIP8_9CLOT
          Length = 441

 Score =  124 bits (310), Expect = 4e-27
 Identities = 61/129 (47%), Positives = 81/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +++LTM++R T+ NM +EAG KNG+ P D  T  Y++  ++ A
Sbjct: 206 IGVDGALYKSMEFVGDGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTEAYMKEHSTKA 265

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   +D  A +  EY  D+S L P VA PH P+N     E  D+KID+V IGSCT G+ 
Sbjct: 266 YKKYEADADAVYDEEYTIDLSTLRPTVAFPHLPENTKTIDEVGDIKIDQVVIGSCTNGRI 325

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 326 SDMRIAADI 334

[73][TOP]
>UniRef100_C7GFH7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Roseburia
           intestinalis L1-82 RepID=C7GFH7_9FIRM
          Length = 420

 Score =  123 bits (308), Expect = 7e-27
 Identities = 62/137 (45%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D+   +Y+E  +   
Sbjct: 186 IGVDGALYKSMEFVGDGISFLSMDDRFTIANMAIEAGGKNGIFPVDNLAKEYMEAHSKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +   Y  D+S L+P VA PH P+N     E  D+KID+V IGSCT G+ 
Sbjct: 246 YVVYEADEDAEYEETYTIDLSTLKPTVAFPHLPENTKTIDEVGDIKIDQVVIGSCTNGRM 305

Query: 361 EDFMAAAKIFLASGKTV 411
           +D   AA I    GK V
Sbjct: 306 DDLRVAASIL--KGKKV 320

[74][TOP]
>UniRef100_C0FIT9 Putative uncharacterized protein n=1 Tax=Clostridium sp. M62/1
           RepID=C0FIT9_9CLOT
          Length = 278

 Score =  123 bits (308), Expect = 7e-27
 Identities = 61/138 (44%), Positives = 86/138 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  + +L+M++R T+CNM +EAGGKNG+ P D    +Y++  +   
Sbjct: 43  IGVDGALYKSMEFTGDGIRNLSMDDRFTICNMAIEAGGKNGIFPVDEKAVQYMKEHSKRE 102

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D+ A + + Y  D+S L+P VA PH P+N     E  DV ID+V IGSCT G+ 
Sbjct: 103 FQIHEADEDAEYEAVYTIDLSALKPTVAFPHLPENTKTIDEAGDVAIDQVVIGSCTNGRL 162

Query: 361 EDFMAAAKIFLASGKTVK 414
           ED   AA+I    G+ VK
Sbjct: 163 EDMRIAAEIL--KGRKVK 178

[75][TOP]
>UniRef100_Q46B45 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosarcina
           barkeri str. Fusaro RepID=Q46B45_METBF
          Length = 413

 Score =  123 bits (308), Expect = 7e-27
 Identities = 60/139 (43%), Positives = 84/139 (60%)
 Frame = +1

Query: 7   VAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYE 186
           + GATYK++EF G  +  L++  RMTLCNM +E G K G+VP D  T+ +L+ + +  Y+
Sbjct: 185 IDGATYKAVEFYGQAISELSVSGRMTLCNMAIEMGAKTGIVPPDEKTFAFLKNRAAAPYD 244

Query: 187 PVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
           PVY+DQ A ++ E  +    +EP VA PH  DN     E +   ID+V+IG+CT G+ ED
Sbjct: 245 PVYADQDAVYVKEPVYSAEDIEPQVACPHQVDNVKPVGEVEGTHIDQVFIGTCTNGRLED 304

Query: 367 FMAAAKIFLASGKTVKVPT 423
              AA I    GK V V T
Sbjct: 305 LEVAAAIL--KGKKVAVRT 321

[76][TOP]
>UniRef100_C9LTJ0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Selenomonas
           sputigena ATCC 35185 RepID=C9LTJ0_9FIRM
          Length = 420

 Score =  122 bits (307), Expect = 9e-27
 Identities = 61/128 (47%), Positives = 81/128 (63%), Gaps = 1/128 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKS+EF G  V +LTM +R+T+ NM +EAG KNG+ P D  T +Y+EG+   A
Sbjct: 185 IGVDGALYKSLEFTGEGVAALTMTDRLTIANMAIEAGAKNGIFPFDEKTKEYVEGRVKGA 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE-CKDVKIDRVYIGSCTGGK 357
           YEPV SD  A++      D+S L P+VA PH P N     +  + +KID+V IGSCT G+
Sbjct: 245 YEPVTSDADAKYCRTVEIDLSSLRPVVAFPHLPGNTKRVMDIAEPIKIDQVVIGSCTNGR 304

Query: 358 TEDFMAAA 381
            ED   +A
Sbjct: 305 LEDLEISA 312

[77][TOP]
>UniRef100_B9XBH0 Aconitate hydratase domain protein n=1 Tax=bacterium Ellin514
           RepID=B9XBH0_9BACT
          Length = 455

 Score =  122 bits (307), Expect = 9e-27
 Identities = 66/146 (45%), Positives = 92/146 (63%), Gaps = 5/146 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK---- 168
           I   GATY++M+F G+ V SL+M++RMT+ NM +EAGGKNG+   D+ T  +++ +    
Sbjct: 209 IGFDGATYRAMQFDGSGVASLSMDDRMTIANMAIEAGGKNGIFEFDAQTKAFVDYRCKLN 268

Query: 169 -TSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   Y+PV  D   +F+ +   D+SKLEP VA    P  R  A+E  DVK+DR YIGSC
Sbjct: 269 GTKATYQPVERDANEKFVYDMVVDLSKLEPTVACHPDPGQRKKAKE-MDVKLDRAYIGSC 327

Query: 346 TGGKTEDFMAAAKIFLASGKTVKVPT 423
           TGGKT DF+  A++    GK V + T
Sbjct: 328 TGGKTSDFLEFARVL--KGKRVMIDT 351

[78][TOP]
>UniRef100_A8S7H1 Putative uncharacterized protein n=1 Tax=Faecalibacterium
           prausnitzii M21/2 RepID=A8S7H1_9FIRM
          Length = 419

 Score =  122 bits (307), Expect = 9e-27
 Identities = 65/132 (49%), Positives = 82/132 (62%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTS-- 174
           I V GA YKSMEF G  V  LTM++R+ +CNM +EAG KNG+ P D  T  YL G++   
Sbjct: 186 IGVDGALYKSMEFTGPGVAGLTMDDRLCICNMAIEAGAKNGIFPVDEVTKAYLAGRSQRP 245

Query: 175 -VAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTG 351
            V YE   +D  A +      D+S LEP V+ PH P+N  +A E KD+KID+V IGSCT 
Sbjct: 246 PVFYE---ADPDAVYEKTIEIDLSALEPTVSYPHLPENTHVASEGKDIKIDQVVIGSCTN 302

Query: 352 GKTEDFMAAAKI 387
           G+ ED  AA  I
Sbjct: 303 GRLEDMEAAYNI 314

[79][TOP]
>UniRef100_Q24XT4 3-isopropylmalate dehydratase large subunit n=2
           Tax=Desulfitobacterium hafniense RepID=LEUC_DESHY
          Length = 421

 Score =  122 bits (305), Expect = 2e-26
 Identities = 58/129 (44%), Positives = 82/129 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  + +L+M+ R+T+CNM VEAG KNG++P D  T  Y+  +    
Sbjct: 187 IGVDGARYRSMEFTGEGIAALSMDGRLTMCNMAVEAGAKNGIIPPDEKTLAYVNERAKRP 246

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+  +SD  A+++  Y +DV+ +   VA PH P+N     E K +KID+V IGSCT G+ 
Sbjct: 247 YKVYHSDPDAQYVEVYEWDVADIPLQVAFPHLPENAKPVSEGKGIKIDQVVIGSCTNGRL 306

Query: 361 EDFMAAAKI 387
           ED   AA+I
Sbjct: 307 EDMQVAAQI 315

[80][TOP]
>UniRef100_A5FS15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FS15_DEHSB
          Length = 431

 Score =  122 bits (305), Expect = 2e-26
 Identities = 60/131 (45%), Positives = 84/131 (64%), Gaps = 1/131 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATYK++EF G  V ++T+ ER+T+ NM VEAG K G+ P+D  T +YL      A
Sbjct: 196 IGADGATYKALEFSGNVVNNMTVAERLTIANMAVEAGAKVGLFPSDRQTLEYLRSVGREA 255

Query: 181 -YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            Y+P+ +D  A +      D + LEP ++KPH+ DN A ARE K  K+D+V+IG+CTGG+
Sbjct: 256 DYQPLAADADAVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFIGTCTGGR 315

Query: 358 TEDFMAAAKIF 390
            +D   AA IF
Sbjct: 316 LDDLAVAAAIF 326

[81][TOP]
>UniRef100_C4ZBK5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Eubacterium
           rectale ATCC 33656 RepID=C4ZBK5_EUBR3
          Length = 420

 Score =  121 bits (304), Expect = 2e-26
 Identities = 63/137 (45%), Positives = 84/137 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D  T +Y++  +   
Sbjct: 186 IGVDGALYKSMEFVGDGLKYLSMDDRFTIANMAIEAGGKNGIFPVDDLTREYMKEHSKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +    +D  A +  EY  D+S L+  V+ PH PDN     E  DVKID+V IGSCT G+ 
Sbjct: 246 FTEYEADSDAEYDEEYTIDLSTLKSTVSFPHLPDNTRTIDEVGDVKIDQVVIGSCTNGRM 305

Query: 361 EDFMAAAKIFLASGKTV 411
           +D   AAKI    GK V
Sbjct: 306 DDLRIAAKIL--EGKKV 320

[82][TOP]
>UniRef100_B1I1Y2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Candidatus
           Desulforudis audaxviator MP104C RepID=B1I1Y2_DESAP
          Length = 420

 Score =  121 bits (304), Expect = 2e-26
 Identities = 59/129 (45%), Positives = 82/129 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G  + +L+M+ R T+ NM +EAG KNG++  D  T +Y++G+T   
Sbjct: 186 IGVEGALYQAMEFTGPAIANLSMDGRFTMANMAIEAGAKNGIIAPDIRTLEYVQGRTIRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E   SD  A +     +DVSK+EP VA PHSPDN     E   V+ID+V IGSCT G+ 
Sbjct: 246 FELFASDPDAVYARTITYDVSKIEPQVAFPHSPDNTRPVTEAGRVEIDQVVIGSCTNGRM 305

Query: 361 EDFMAAAKI 387
           ED   AA++
Sbjct: 306 EDLRLAARV 314

[83][TOP]
>UniRef100_UPI00019E5A8A 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=UPI00019E5A8A
          Length = 310

 Score =  121 bits (303), Expect = 3e-26
 Identities = 63/137 (45%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G  +E L+M+ R+T+ NM +EAGGKNG+V  D  T  Y+EG+    
Sbjct: 76  IGVDGALYKAMEFAGPAIEKLSMDGRLTMANMAIEAGGKNGIVAPDEITRAYVEGRVKKP 135

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  A +    R+D SK+EPLVA PH P+N     +   V++D+V IGSCT G+ 
Sbjct: 136 YTFYKSDADAVYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGLVELDQVVIGSCTNGRM 195

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA +    GK V
Sbjct: 196 EDLRLAAGVL--KGKKV 210

[84][TOP]
>UniRef100_C8W661 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=C8W661_9FIRM
          Length = 420

 Score =  121 bits (303), Expect = 3e-26
 Identities = 63/137 (45%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G  +E L+M+ R+T+ NM +EAGGKNG+V  D  T  Y+EG+    
Sbjct: 186 IGVDGALYKAMEFAGPAIEKLSMDGRLTMANMAIEAGGKNGIVAPDEITRAYVEGRVKKP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  A +    R+D SK+EPLVA PH P+N     +   V++D+V IGSCT G+ 
Sbjct: 246 YTFYKSDADAVYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGLVELDQVVIGSCTNGRM 305

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA +    GK V
Sbjct: 306 EDLRLAAGVL--KGKKV 320

[85][TOP]
>UniRef100_A8CU07 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           VS RepID=A8CU07_9CHLR
          Length = 417

 Score =  121 bits (303), Expect = 3e-26
 Identities = 60/131 (45%), Positives = 84/131 (64%), Gaps = 1/131 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATYK++EF G  V ++ + ER+T+ NM VEAG K G+ P+D  T +YL      A
Sbjct: 182 IGADGATYKALEFSGNVVNNMMIAERLTIANMAVEAGAKVGLFPSDRQTLEYLRSVGREA 241

Query: 181 -YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            Y+P+ +D+ A +      D + LEP V+KPH+ DN A ARE K  K+D+V+IG+CTGG+
Sbjct: 242 DYQPLAADENAVYERVIEIDATALEPTVSKPHTVDNTATARELKGTKLDQVFIGTCTGGR 301

Query: 358 TEDFMAAAKIF 390
            +D   AA IF
Sbjct: 302 LDDLAVAAAIF 312

[86][TOP]
>UniRef100_A8AB09 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ignicoccus
           hospitalis KIN4/I RepID=A8AB09_IGNH4
          Length = 419

 Score =  121 bits (303), Expect = 3e-26
 Identities = 61/129 (47%), Positives = 85/129 (65%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ++V GATYK++E+ G T++ + + +RMTL NM VE G K G+VPAD  T K+ E +  ++
Sbjct: 186 VTVDGATYKAVEYHGDTIKRMNIADRMTLANMSVEMGAKAGMVPADEVTVKFFE-EAGIS 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
            +P   D  A++   + FDVSKLEP VA PHS DN     E +   ID+ +IGSCT G+ 
Sbjct: 245 VKPFGPDPGAQYEDVWEFDVSKLEPQVAVPHSVDNVVAVGEVEGTPIDQAFIGSCTNGRY 304

Query: 361 EDFMAAAKI 387
           EDF+ AAKI
Sbjct: 305 EDFVEAAKI 313

[87][TOP]
>UniRef100_O67078 3-isopropylmalate dehydratase large subunit n=1 Tax=Aquifex
           aeolicus RepID=LEUC_AQUAE
          Length = 432

 Score =  121 bits (303), Expect = 3e-26
 Identities = 59/138 (42%), Positives = 87/138 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G T+ +L+ME+R T+ NM +EAGGK+G++  D  T +Y++ +    
Sbjct: 185 IGVDGALYRAMEFDGETIRNLSMEQRFTIANMAIEAGGKSGIISPDEKTIEYVKQRAKRP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   SD  A + S Y +D S++EPLVA P+ P N     E   + ID+ +IGSCT G+ 
Sbjct: 245 WKVYQSDPDAEYHSVYEWDASQIEPLVAWPYLPSNVHPVSESTHITIDQAFIGSCTNGRI 304

Query: 361 EDFMAAAKIFLASGKTVK 414
           ED   AAK+F A+ K  K
Sbjct: 305 EDLRVAAKVFEAALKQGK 322

[88][TOP]
>UniRef100_B9L0Y1 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0Y1_THERP
          Length = 422

 Score =  120 bits (301), Expect = 5e-26
 Identities = 61/129 (47%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y  MEF G  ++ L M++R+T+ NM +EAG K G+   D  T ++L   T+  
Sbjct: 188 IGVDGALYACMEFTGPVIDQLPMDDRITMANMAIEAGAKTGIFACDDKTREWLAKVTTEP 247

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPV SD  AR+     FDVS L PLVA PH P N   A E +D+ ID+V IGSCT G+ 
Sbjct: 248 YEPVDSDPDARYAQIIEFDVSNLRPLVALPHLPSNVRPADEVRDLPIDQVVIGSCTNGRL 307

Query: 361 EDFMAAAKI 387
            D   AA+I
Sbjct: 308 SDLRIAAEI 316

[89][TOP]
>UniRef100_C0D3T2 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0D3T2_9CLOT
          Length = 446

 Score =  120 bits (301), Expect = 5e-26
 Identities = 59/129 (45%), Positives = 81/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  V++LTM++R T+CNM +EAGGKNG+ P D  T  YL+  +   
Sbjct: 212 IGVDGALYKSMEFTGEGVKNLTMDDRFTICNMAIEAGGKNGIFPVDEQTVAYLKEHSKRD 271

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D  A + + Y  D+S+L+P V+ PH P N        DVKID+  IGSCT G+ 
Sbjct: 272 FKVYEADPDAEYDATYVIDLSELKPTVSFPHLPSNTRTIDNVGDVKIDQSVIGSCTNGRI 331

Query: 361 EDFMAAAKI 387
           +D   AA+I
Sbjct: 332 DDMRVAAEI 340

[90][TOP]
>UniRef100_A1HLS2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HLS2_9FIRM
          Length = 420

 Score =  120 bits (301), Expect = 5e-26
 Identities = 62/137 (45%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+S+EF G  V +LTM +R+T+ NM +EAG KNG+ P D  T +YL  +    
Sbjct: 185 IGVDGARYQSLEFCGEGVAALTMADRLTIANMAIEAGAKNGIFPVDDATIRYLSTRVERD 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE V  D  A ++     ++  LEP+VA PH P+N   A + +D+ ID+V IGSCT G+ 
Sbjct: 245 YEAVSPDADASYVRTVVINLDDLEPVVALPHLPENVRPAAQVRDIAIDQVVIGSCTNGRL 304

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA I    GKTV
Sbjct: 305 EDLAQAAAIL--EGKTV 319

[91][TOP]
>UniRef100_Q3ZZK0 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           CBDB1 RepID=Q3ZZK0_DEHSC
          Length = 417

 Score =  120 bits (300), Expect = 6e-26
 Identities = 60/131 (45%), Positives = 84/131 (64%), Gaps = 1/131 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATYK++EF G  V ++T+ ER+T+ NM VEAG K G+ P+D  T +YL      A
Sbjct: 182 IGADGATYKALEFSGNVVNNMTVAERLTIANMAVEAGAKVGLFPSDRQTLEYLCSVGREA 241

Query: 181 -YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            Y+P+ +D  A +      D + LEP ++KPH+ DN A ARE K  K+D+V+IG+CTGG+
Sbjct: 242 DYQPLAADVDAVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFIGTCTGGR 301

Query: 358 TEDFMAAAKIF 390
            +D   AA IF
Sbjct: 302 LDDLAVAAAIF 312

[92][TOP]
>UniRef100_C8WM14 3-isopropylmalate dehydratase, large subunit n=2 Tax=Eggerthella
           lenta DSM 2243 RepID=C8WM14_9ACTN
          Length = 422

 Score =  120 bits (300), Expect = 6e-26
 Identities = 58/137 (42%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G+ + ++ M+ERM++ NM +EAGGK G++  D  T  YL+G+T   
Sbjct: 188 IGVDGALYQAMEFTGSAIRAMDMDERMSISNMAIEAGGKAGLIEVDDVTRAYLDGRTERP 247

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y   +SD  A +   Y  D + + P V+ PH P N   A E +DVKID+  IGSCT G+ 
Sbjct: 248 YTEYHSDADATYAKVYEIDAASIVPTVSFPHLPSNTRPAAEARDVKIDQAVIGSCTNGRI 307

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA +    G+TV
Sbjct: 308 ADMRQAADVL--RGRTV 322

[93][TOP]
>UniRef100_Q3AEQ4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AEQ4_CARHZ
          Length = 421

 Score =  119 bits (299), Expect = 8e-26
 Identities = 59/138 (42%), Positives = 85/138 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G+ ++ +++E R+T+ NM +EAG KNG+ P D  T +Y++G+    
Sbjct: 187 IGVDGALYKAMEFAGSALKLISVEGRLTMANMAIEAGAKNGIFPVDELTLEYVKGRAKRE 246

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   SD  AR+ + Y  +V ++EP VA PH P+N    +E     ID+V IGSCT G+ 
Sbjct: 247 FKVFASDPDARYEAVYEINVEEIEPQVALPHLPENAVPVKEVSGKDIDQVVIGSCTNGRI 306

Query: 361 EDFMAAAKIFLASGKTVK 414
           ED   AA I    GK VK
Sbjct: 307 EDLRVAAAIL--KGKKVK 322

[94][TOP]
>UniRef100_C9KJM7 3-isopropylmalate dehydratase, large subunit n=2 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KJM7_9FIRM
          Length = 420

 Score =  119 bits (299), Expect = 8e-26
 Identities = 59/130 (45%), Positives = 84/130 (64%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKS+EF G  V++LTM +R+T+ NM +EAGGK G+ P D  T  Y++ + +  
Sbjct: 185 IGVDGALYKSLEFAGPGVKALTMTDRLTISNMAIEAGGKAGIFPFDEITKAYVDARVTKP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD-VKIDRVYIGSCTGGK 357
           YEPV +D  A +  E   ++S+L+P+VA PH P N     + K+ ++ID+V IGSCT G+
Sbjct: 245 YEPVAADDDAEYCREVDINLSELKPVVAFPHLPGNTKRVEDIKEPIEIDQVIIGSCTNGR 304

Query: 358 TEDFMAAAKI 387
            ED   AA I
Sbjct: 305 LEDMEIAASI 314

[95][TOP]
>UniRef100_UPI00016C08CB 3-isopropylmalate dehydratase, large subunit n=1 Tax=Epulopiscium
           sp. 'N.t. morphotype B' RepID=UPI00016C08CB
          Length = 421

 Score =  119 bits (298), Expect = 1e-25
 Identities = 63/137 (45%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ L+M+ R T+ NM +EAG KNG+   D  T +YL+G+T   
Sbjct: 186 IGVDGALYKSMEFVGDGIQHLSMDSRFTMANMAIEAGAKNGIFEVDFITREYLKGRTDRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  A +      D+SK+ P V+ PHSPDN     E  ++KID+V IGSCT G+ 
Sbjct: 246 YIVYTSDADAIYDEVITIDLSKVRPTVSCPHSPDNTXTLDELPEIKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   A+ I    GK V
Sbjct: 306 EDLRMASDIL--KGKKV 320

[96][TOP]
>UniRef100_B0PBC0 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PBC0_9FIRM
          Length = 419

 Score =  119 bits (298), Expect = 1e-25
 Identities = 61/137 (44%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  +  L+M++R+T+ NM +EAGGKNG+   D  T  Y++G+ +  
Sbjct: 186 IGVDGALYQSMEFGGEGLRHLSMDDRLTMANMAIEAGGKNGIFEVDEVTRAYMQGRVNRT 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE    D  A +      D+S + P VA PH P+N     E  DV+ID+V IGSCT G+ 
Sbjct: 246 YETFMPDDGAAYARVIEIDLSSIRPTVAFPHLPENTRTVDEAGDVRIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D  AAA+  L SGK V
Sbjct: 306 GDLAAAAR--LMSGKKV 320

[97][TOP]
>UniRef100_Q0W1Q4 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W1Q4_UNCMA
          Length = 414

 Score =  119 bits (298), Expect = 1e-25
 Identities = 60/137 (43%), Positives = 82/137 (59%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           GATYK+MEF G  ++ +++  RMTLCNM +E GGK G+VP D  T+ +L+G+    Y PV
Sbjct: 187 GATYKAMEFYGPVIDHMSIAGRMTLCNMAIEMGGKAGIVPPDEKTFAFLKGRAVEEYRPV 246

Query: 193 YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFM 372
           Y+ + A +  E   DVSKL P V+ P   DN     E +   +D+V IGSCT G+ ED  
Sbjct: 247 YASRDAVYCDELHLDVSKLHPQVSCPPDVDNVKDVGEVEGTHVDQVLIGSCTNGRYEDLA 306

Query: 373 AAAKIFLASGKTVKVPT 423
            AA I    G+ V+  T
Sbjct: 307 GAAAIL--KGRKVRCRT 321

[98][TOP]
>UniRef100_A8UWH6 3-isopropylmalate dehydratase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1
           RepID=A8UWH6_9AQUI
          Length = 432

 Score =  119 bits (297), Expect = 1e-25
 Identities = 58/140 (41%), Positives = 86/140 (61%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G  +  L++E+R+T+ NM +EAGGK+G++  D  T +Y++ +    
Sbjct: 185 IGVDGALYRAMEFEGEAIRELSVEQRLTITNMAIEAGGKSGIIAPDDKTIEYVKERAQKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   SD  A + S Y +D SK+EPLVA P+ P N     E   + +D+ +IGSCT G+ 
Sbjct: 245 WKVYESDPDAEYHSVYEWDASKIEPLVAWPYLPSNVHPVSESTHINVDQAFIGSCTNGRI 304

Query: 361 EDFMAAAKIF---LASGKTV 411
           ED   AAK+F   L  GK V
Sbjct: 305 EDLRIAAKVFESALKQGKKV 324

[99][TOP]
>UniRef100_C8SB74 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SB74_FERPL
          Length = 419

 Score =  119 bits (297), Expect = 1e-25
 Identities = 64/132 (48%), Positives = 83/132 (62%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           +   GA YK+ EFVG+T+E + M ER+T+ NM +E GGK G++P D  T  YL+    V 
Sbjct: 185 VGANGANYKACEFVGSTIEKMEMSERLTMTNMAIEMGGKTGIIPPDKVTEDYLK-SIGVD 243

Query: 181 YEP---VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTG 351
           YE    +YSD+ A +  E   DVS LEP VA PHS DN     E + VKID+V+IGSCT 
Sbjct: 244 YEIPEWLYSDEDA-YWKEVSLDVSNLEPQVACPHSVDNVKPVSEVEGVKIDQVFIGSCTN 302

Query: 352 GKTEDFMAAAKI 387
           G+ ED   AA+I
Sbjct: 303 GRYEDLKVAAEI 314

[100][TOP]
>UniRef100_A9KT79 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           phytofermentans ISDg RepID=LEUC_CLOPH
          Length = 421

 Score =  119 bits (297), Expect = 1e-25
 Identities = 57/129 (44%), Positives = 81/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +++LTM++R T+ NM +EAG KNG+ P D  T  Y++   +  
Sbjct: 186 IGVDGALYKSMEFVGAGIKNLTMDDRFTIANMAIEAGAKNGIFPVDDLTISYMKEHGAKP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +      ++S+LEP VA PH P+N    +E  +V+ID+V IGSCT G+ 
Sbjct: 246 YTIYEADEDAEYEQIITINLSELEPTVAFPHLPENTKTVKEAGEVRIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
            D   AAK+
Sbjct: 306 GDLRIAAKV 314

[101][TOP]
>UniRef100_Q8U2A1 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           furiosus RepID=LEUC1_PYRFU
          Length = 424

 Score =  119 bits (297), Expect = 1e-25
 Identities = 58/131 (44%), Positives = 86/131 (65%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK MEF G  +E L++E+RMT+ NM +EAG K G++  D  T +Y++G+    
Sbjct: 187 IGVNGALYKVMEFSGEVIEKLSVEQRMTMTNMAIEAGAKTGIIEPDKKTIEYVKGRAKRE 246

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRA-LARECK-DVKIDRVYIGSCTGG 354
           Y+   SD+ A++     +DVSK+EP VA PH P+N   +++  K ++KID+V IGSCT G
Sbjct: 247 YKIYKSDEDAKYYKVIEYDVSKIEPQVAFPHLPENTVPISKAAKMNIKIDQVVIGSCTNG 306

Query: 355 KTEDFMAAAKI 387
           + ED   AA++
Sbjct: 307 RLEDLRMAAEV 317

[102][TOP]
>UniRef100_C0R088 3-isopropylmalate dehydratase large subunit n=1 Tax=Brachyspira
           hyodysenteriae WA1 RepID=C0R088_BRAHW
          Length = 415

 Score =  118 bits (296), Expect = 2e-25
 Identities = 63/137 (45%), Positives = 81/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  V SLTM++R  + NM +EAG KNG+   D  T +YL+      
Sbjct: 184 IGVDGALYKSMEFRGEGVSSLTMDDRACIANMAIEAGAKNGIFEVDDQTIEYLKDIVKRD 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D  A +  EY  D+S +EP VA PH P+N   A+E K++K+D+V IGSCT G+ 
Sbjct: 244 YTVFKADDDAVYDKEYDIDLSLIEPTVACPHLPENTKEAKELKNIKVDQVVIGSCTNGRL 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA I    GK V
Sbjct: 304 SDMATAANIL--KGKKV 318

[103][TOP]
>UniRef100_A9BGP4 3-isopropylmalate dehydratase, large subunit n=1 Tax=Petrotoga
           mobilis SJ95 RepID=A9BGP4_PETMO
          Length = 419

 Score =  118 bits (296), Expect = 2e-25
 Identities = 60/129 (46%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKS+EF G T+E L+M+ RMT+ NM +EAG K G+   D  T +YL+ +    
Sbjct: 184 IGVDGALYKSIEFTGETIEDLSMDSRMTMANMAIEAGAKCGLFEYDEKTKEYLKERAVRD 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y PV SD  A +     +DVS +EP VA PH P+N     E K +KID+  IGSCT G+ 
Sbjct: 244 YTPVSSDPDASYEEVIEYDVSNIEPQVAFPHLPENTKPVTEAKRIKIDQSVIGSCTNGRI 303

Query: 361 EDFMAAAKI 387
           ED   AA +
Sbjct: 304 EDLRIAAHV 312

[104][TOP]
>UniRef100_C7LW15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LW15_DESBD
          Length = 420

 Score =  118 bits (296), Expect = 2e-25
 Identities = 57/127 (44%), Positives = 77/127 (60%)
 Frame = +1

Query: 7   VAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYE 186
           VAGA YK++EF G  +E L++E RMT+ NM +EAGGK G+  AD  T  Y +    +   
Sbjct: 188 VAGALYKALEFGGEIIEGLSVEARMTMANMAIEAGGKAGLFAADEKTLAYCQAHGRMGDS 247

Query: 187 PVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
           P+ +D+ A +  E  FDVS   P +A PH PDN     E  DV++D+V +GSCT G+  D
Sbjct: 248 PIAADEGAHYWKEMTFDVSSFSPQIACPHLPDNVRPVEEVSDVRVDQVVLGSCTNGRISD 307

Query: 367 FMAAAKI 387
              AAKI
Sbjct: 308 LREAAKI 314

[105][TOP]
>UniRef100_C4G1B4 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1B4_ABIDE
          Length = 421

 Score =  118 bits (296), Expect = 2e-25
 Identities = 59/137 (43%), Positives = 84/137 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++LTM++R T+ NM +EAG KNG+ P D  T  Y++  ++  
Sbjct: 186 IGVDGALYKSMEFTGDGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTLNYIKEHSTKP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   +D+ A +      ++S+LEP VA PH P+N     E  D+KID+V IGSCT G+ 
Sbjct: 246 YKVYEADEDAVYDEVIEINLSELEPTVAFPHLPENTRTIGETGDIKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA++    GK V
Sbjct: 306 SDIRVAAEVM--KGKKV 320

[106][TOP]
>UniRef100_Q7M9Z9 3-isopropylmalate dehydratase large subunit n=1 Tax=Wolinella
           succinogenes RepID=LEUC_WOLSU
          Length = 422

 Score =  118 bits (296), Expect = 2e-25
 Identities = 63/141 (44%), Positives = 91/141 (64%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G T+E L+M++R +LCNM +EAG KNG++ ADS T ++L  + S+ 
Sbjct: 185 IGVDGALYKALEFQGDTIEQLSMDDRFSLCNMAIEAGAKNGIIAADSITKEFLASRKSLR 244

Query: 181 YEPVY--SDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECK-DVKIDRVYIGSCT 348
            EP Y  +D  A +      DV KLEP++A P  P N +++++  K D+KID+ +IGSCT
Sbjct: 245 AEPKYYQADADALYEQTIEIDVEKLEPVIAYPFLPSNGKSISQAVKDDLKIDQAFIGSCT 304

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   AA+I    GK V
Sbjct: 305 NGRLSDLRIAAQIL--KGKRV 323

[107][TOP]
>UniRef100_A8RZ58 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RZ58_9CLOT
          Length = 420

 Score =  118 bits (295), Expect = 2e-25
 Identities = 54/129 (41%), Positives = 81/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  + +L+M++R T+CNM +EAGGKNG+ P D    +Y++  +   
Sbjct: 186 IGVDGALYKSMEFVGEGIRNLSMDDRFTICNMAIEAGGKNGIFPVDELAVEYMKEHSKRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +    +D+ A +   Y  D+S+L+P V+ PH P N     +  +VK+D+  IGSCT G+ 
Sbjct: 246 FTVYEADEDAEYDETYVIDLSELKPTVSFPHLPSNTRTIDQVGEVKVDQAVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED   AA++
Sbjct: 306 EDMRIAAEV 314

[108][TOP]
>UniRef100_Q8TVF2 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Methanopyrus
           kandleri RepID=LEUC1_METKA
          Length = 418

 Score =  118 bits (295), Expect = 2e-25
 Identities = 57/129 (44%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY ++E+ G  V  +++ +RM LCNM +E G K G+VP D  T +Y++ +    
Sbjct: 184 IGADGATYMAIEYHGEVVREMSVSDRMCLCNMAIEMGAKTGMVPPDEKTLEYVKKRAGTE 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
             PV  D  AR+ +E   DVS LEP VAKP SPDN     E + + ID+V+IGSCT G+ 
Sbjct: 244 GRPVEPDPDARYEAELTLDVSDLEPQVAKPFSPDNVVPVGEVEGIAIDQVFIGSCTNGRY 303

Query: 361 EDFMAAAKI 387
           ED   AA++
Sbjct: 304 EDLKVAAEV 312

[109][TOP]
>UniRef100_Q2FSZ6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanospirillum hungatei JF-1 RepID=Q2FSZ6_METHJ
          Length = 417

 Score =  117 bits (294), Expect = 3e-25
 Identities = 61/129 (47%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+V GATYK++EF G T+ESL M  RMT CNM +E GGK G+VP D  T +YL G+ +  
Sbjct: 183 ITVDGATYKTVEFTGDTIESLNMAGRMTCCNMAIEMGGKAGIVPPDQVTKEYLSGRGTWR 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
            E + SD  A + S   +DVS L P VA PH+ D      E     +D+V+IGSCT G+ 
Sbjct: 243 EENLASDPDAVYASWRDYDVSDLVPQVAVPHNVDQVVDVTEIAGTHVDQVFIGSCTNGRF 302

Query: 361 EDFMAAAKI 387
           ED   AA +
Sbjct: 303 EDLKEAALV 311

[110][TOP]
>UniRef100_B9D2G7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           rectus RM3267 RepID=B9D2G7_WOLRE
          Length = 424

 Score =  117 bits (293), Expect = 4e-25
 Identities = 60/133 (45%), Positives = 87/133 (65%), Gaps = 4/133 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G T+E+L M+ R ++CNM +EAGGK+G++  D TT ++L+GK ++ 
Sbjct: 188 IGVDGALYKALEFTGETIENLDMDGRFSMCNMAIEAGGKSGIIAVDETTKEFLKGK-NLR 246

Query: 181 YEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVYIGSCT 348
            EP   YSD+ A +    + DVSKL+P++A P  P N    RE    D+ ID+ +IGSCT
Sbjct: 247 AEPKLHYSDEGANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVKDDIAIDQAFIGSCT 306

Query: 349 GGKTEDFMAAAKI 387
            G+  D   AA+I
Sbjct: 307 NGRLSDLRIAAEI 319

[111][TOP]
>UniRef100_B1QZX5 3-isopropylmalate dehydratase, large subunit n=2 Tax=Clostridium
           butyricum RepID=B1QZX5_CLOBU
          Length = 419

 Score =  117 bits (293), Expect = 4e-25
 Identities = 61/137 (44%), Positives = 80/137 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL+      
Sbjct: 186 IGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDEKTEEYLKDHAKRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D+ A++   Y  D+S L P V+ PH PDN        DVKID+V IGSCT G+ 
Sbjct: 246 WKKYEADEDAQYDEVYEIDLSTLRPTVSFPHLPDNTRTIDNTGDVKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   A  I    GK V
Sbjct: 306 SDLRVARDIL--KGKKV 320

[112][TOP]
>UniRef100_A6LPX4 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           beijerinckii NCIMB 8052 RepID=LEUC_CLOB8
          Length = 419

 Score =  117 bits (293), Expect = 4e-25
 Identities = 61/138 (44%), Positives = 82/138 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D  T +YL+   S  
Sbjct: 186 IGVDGALYKSMEFVGDGLQYLSMDDRFTMANMAIEAGGKNGIFPVDDKTEEYLKDHASRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D+ A +   +  D+S+L P V+ PH PDN        DV ID+V IGSCT G+ 
Sbjct: 246 WKVYEADEDAEYDKVFEIDLSELRPTVSFPHLPDNTRTIDNTGDVAIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTVK 414
            D   A  I    GK VK
Sbjct: 306 SDLRMARDIL--KGKKVK 321

[113][TOP]
>UniRef100_C6RH21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           showae RM3277 RepID=C6RH21_9PROT
          Length = 424

 Score =  117 bits (292), Expect = 5e-25
 Identities = 60/133 (45%), Positives = 86/133 (64%), Gaps = 4/133 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G T+E+L M+ R ++CNM +EAGGK+G++  D TT ++L+GK ++ 
Sbjct: 188 IGVDGALYKALEFTGETIENLDMDGRFSMCNMAIEAGGKSGIIAVDETTKEFLKGK-NLR 246

Query: 181 YEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVYIGSCT 348
            EP   YSD+ A +      DVSKL+P++A P  P N    RE    D+ ID+ +IGSCT
Sbjct: 247 AEPKLHYSDEGANYEQILEIDVSKLDPVIAYPFLPSNGKSVREAVRDDIAIDQAFIGSCT 306

Query: 349 GGKTEDFMAAAKI 387
            G+  D   AA+I
Sbjct: 307 NGRLSDLRIAAEI 319

[114][TOP]
>UniRef100_C1TNL5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNL5_9BACT
          Length = 419

 Score =  117 bits (292), Expect = 5e-25
 Identities = 62/137 (45%), Positives = 79/137 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ISV GA Y ++EF G  + S++M+ R T+ NM VEAGGK G+   D TT  Y E + S  
Sbjct: 184 ISVQGARYMALEFGGDALASMSMDHRFTVANMAVEAGGKAGLFVPDETTLAYAEARASRP 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +   Y D+   +      DV KL PLVA PHSPDN   A    D +I +V+IGSCT G+ 
Sbjct: 244 FTARYPDEGCEYAKRVEIDVEKLTPLVAAPHSPDNVRPASTFGDTEIQQVFIGSCTNGRL 303

Query: 361 EDFMAAAKIFLASGKTV 411
           ED  AAA +    GK V
Sbjct: 304 EDMAAAASVL--EGKKV 318

[115][TOP]
>UniRef100_C0EDN6 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EDN6_9CLOT
          Length = 421

 Score =  117 bits (292), Expect = 5e-25
 Identities = 61/137 (44%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++LTM++R+ + NM +EAGGKNG+   D  T  Y++ K +  
Sbjct: 186 IGVDGALYKSMEFGGEGLKNLTMDDRLCMANMAIEAGGKNGIFEVDEVTIAYMKDKVNRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y     D  A + + Y  D+S+++  V+ PH PDN     E  DVKID+V IGSCT G+ 
Sbjct: 246 YTAYAPDPDAEYDAVYDIDLSQIKSTVSFPHLPDNTRTIDEVGDVKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AAKI    GK V
Sbjct: 306 SDIAVAAKIL--EGKQV 320

[116][TOP]
>UniRef100_Q2NE97 LeuC1 n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NE97_METST
          Length = 418

 Score =  117 bits (292), Expect = 5e-25
 Identities = 58/125 (46%), Positives = 81/125 (64%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           GA YK+ E+ G TV+++ M +RM L NM +E GGK G+VPAD  T +YL+ +T+  Y   
Sbjct: 189 GARYKACEYTGETVQNMDMSDRMVLSNMAIECGGKTGIVPADKITDEYLKNRTTKQYTKF 248

Query: 193 YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFM 372
            +D+ A  L     DVS LEP VA P+  DN   A E +DV+ID+V+IGSCT G+ +D  
Sbjct: 249 TTDKDAASLEVMDIDVSDLEPQVACPNYVDNVKPASEVEDVEIDQVFIGSCTNGRLKDLE 308

Query: 373 AAAKI 387
            AA++
Sbjct: 309 QAARV 313

[117][TOP]
>UniRef100_Q0AV21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Syntrophomonas
           wolfei subsp. wolfei str. Goettingen RepID=Q0AV21_SYNWW
          Length = 419

 Score =  116 bits (291), Expect = 7e-25
 Identities = 57/129 (44%), Positives = 77/129 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y SMEF G  +++L+M+ R T+ NM +EAGGKNG+  AD  T  Y++ +    
Sbjct: 186 IGVDGARYMSMEFTGEVIQNLSMDNRFTMANMAIEAGGKNGIFAADEITLDYVKKRVKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E   SD  A +     +DVSKLEP+VA PH P+N     E   V +D+V IGSCT G+ 
Sbjct: 246 FELYQSDPDAVYFDIKEYDVSKLEPVVAFPHLPENTRPVTEATHVSLDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED    A +
Sbjct: 306 EDMEITASL 314

[118][TOP]
>UniRef100_B9E370 Putative uncharacterized protein n=1 Tax=Clostridium kluyveri NBRC
           12016 RepID=B9E370_CLOK1
          Length = 426

 Score =  116 bits (290), Expect = 9e-25
 Identities = 55/129 (42%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y SMEF G  V  L+M++R T+ NM +EAG KNG+ P D  T +Y++  ++ +
Sbjct: 192 IGVDGALYNSMEFTGEGVGELSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYVKEHSNRS 251

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A ++     D+SK+ P VA PH P+N     E  ++KID+V IGSCT G+ 
Sbjct: 252 YTVYEADEDAEYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEIKIDQVVIGSCTNGRI 311

Query: 361 EDFMAAAKI 387
            D   AAK+
Sbjct: 312 GDLRVAAKV 320

[119][TOP]
>UniRef100_C6LJ75 3-isopropylmalate dehydratase, large subunit n=1 Tax=Bryantella
           formatexigens DSM 14469 RepID=C6LJ75_9FIRM
          Length = 422

 Score =  116 bits (290), Expect = 9e-25
 Identities = 60/139 (43%), Positives = 86/139 (61%), Gaps = 1/139 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  V++L+M++R T+ NM +EAGGKNG+ P D     Y++  +   
Sbjct: 186 IGVDGALYRSMEFTGEGVKNLSMDDRFTIANMAIEAGGKNGIFPVDDLAIAYMKEHSQRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKDVKIDRVYIGSCTGGK 357
           Y+   +D+ A +  EY  D+S L+P VA PH P+N + +    +DV ID+  IGSCT G+
Sbjct: 246 YKIYEADEDAVYDEEYTIDLSALKPTVAFPHLPENTKTIDEITEDVVIDQAVIGSCTNGR 305

Query: 358 TEDFMAAAKIFLASGKTVK 414
            +D   AAKI    G+ VK
Sbjct: 306 IDDLRCAAKIL--EGRKVK 322

[120][TOP]
>UniRef100_A5MZ75 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           kluyveri DSM 555 RepID=LEUC_CLOK5
          Length = 420

 Score =  116 bits (290), Expect = 9e-25
 Identities = 55/129 (42%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y SMEF G  V  L+M++R T+ NM +EAG KNG+ P D  T +Y++  ++ +
Sbjct: 186 IGVDGALYNSMEFTGEGVGELSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYVKEHSNRS 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A ++     D+SK+ P VA PH P+N     E  ++KID+V IGSCT G+ 
Sbjct: 246 YTVYEADEDAEYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEIKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
            D   AAK+
Sbjct: 306 GDLRVAAKV 314

[121][TOP]
>UniRef100_C0CLF7 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CLF7_9FIRM
          Length = 422

 Score =  115 bits (289), Expect = 1e-24
 Identities = 60/139 (43%), Positives = 85/139 (61%), Gaps = 1/139 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D     Y+   +   
Sbjct: 186 IGVDGALYKSMEFVGDGIQHLSMDDRFTIANMAIEAGGKNGIFPVDDLAVAYMREHSKRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKDVKIDRVYIGSCTGGK 357
           ++   +D+ A +  EY  D+S+L+P +A PH P+N R +     DV ID+  IGSCT G+
Sbjct: 246 FKIYEADEDAVYEEEYTIDLSQLKPTIAFPHLPENTRTIDEITADVVIDQSVIGSCTNGR 305

Query: 358 TEDFMAAAKIFLASGKTVK 414
            ED   AA+I    G+ VK
Sbjct: 306 MEDLRIAAEIL--KGRKVK 322

[122][TOP]
>UniRef100_A6Q5L6 3-isopropylmalate dehydratase large subunit n=1 Tax=Nitratiruptor
           sp. SB155-2 RepID=LEUC_NITSB
          Length = 421

 Score =  115 bits (289), Expect = 1e-24
 Identities = 61/133 (45%), Positives = 85/133 (63%), Gaps = 4/133 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G T+E+L M+ R +LCNM +EAG KNG++  D  T  +L  K  +A
Sbjct: 185 IGVDGALYKALEFTGDTIENLDMDGRFSLCNMAIEAGAKNGIIAVDEVTKAFLADK-PLA 243

Query: 181 YEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECK-DVKIDRVYIGSCT 348
            EP   YSD+ A +      DV+ LEP++A PH P N R ++   K D+K+D+V+IGSCT
Sbjct: 244 REPKIHYSDEDAEYEQVIEIDVNNLEPVIAFPHLPSNGRPISEAAKMDLKVDQVFIGSCT 303

Query: 349 GGKTEDFMAAAKI 387
            G+  D   AA+I
Sbjct: 304 NGRLSDIAIAAEI 316

[123][TOP]
>UniRef100_Q97EE0 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           acetobutylicum RepID=LEUC_CLOAB
          Length = 422

 Score =  115 bits (289), Expect = 1e-24
 Identities = 57/138 (41%), Positives = 83/138 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSME+ G  +E L+M++R T+ NM +EAG KNG+ P D  T +Y++G++   
Sbjct: 188 IGVDGALYKSMEYTGDGLEYLSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYMKGRSDRE 247

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
            +   +D+ A +      D+S L+P VA PH P+N     +  +V +D+V IGSCT G+ 
Sbjct: 248 LKKFDADEDAEYSRVIEIDLSTLKPTVAFPHLPENTKTIDQVGEVNVDQVVIGSCTNGRM 307

Query: 361 EDFMAAAKIFLASGKTVK 414
           ED   AA I    GK +K
Sbjct: 308 EDLRIAASIL--KGKKIK 323

[124][TOP]
>UniRef100_C7MMM0 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Cryptobacterium curtum DSM 15641 RepID=C7MMM0_CRYCD
          Length = 423

 Score =  115 bits (288), Expect = 1e-24
 Identities = 60/137 (43%), Positives = 81/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G  +E L++E RMT+ NM +EAGGK G+ P D+TT  YL+ +T   
Sbjct: 189 IGVDGALYQAMEFHGGAIEGLSIEGRMTMANMAIEAGGKAGLFPVDTTTRAYLDARTERP 248

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y     D+ A +      D + + P VA PH P N     E +DV ID+  IGSCT G+ 
Sbjct: 249 YTVYNPDEGAVYARTITIDAADIVPTVAFPHLPSNTRPVAEARDVAIDQAVIGSCTNGRI 308

Query: 361 EDFMAAAKIFLASGKTV 411
           ED  AAA +   +G+TV
Sbjct: 309 EDMRAAAHVL--NGRTV 323

[125][TOP]
>UniRef100_C1I927 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium sp.
           7_2_43FAA RepID=C1I927_9CLOT
          Length = 424

 Score =  115 bits (288), Expect = 1e-24
 Identities = 56/129 (43%), Positives = 77/129 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEFVG  ++ L++++R T+ NM +EAGGKNG+ P D  T +YL       
Sbjct: 186 IGVDGALYRSMEFVGNGLKYLSIDDRFTMANMAIEAGGKNGIFPVDDVTIRYLVDHAQRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D+ A +   Y  D+SKL P VA PH PDN     E  +V +D+V IGSCT G+ 
Sbjct: 246 WKVYEADEDAEYDEVYEIDLSKLRPTVAFPHLPDNTRTIDEVGEVAVDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
            D   A  I
Sbjct: 306 SDLRVARDI 314

[126][TOP]
>UniRef100_B1L3C3 Homoaconitate hydratase family protein n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L3C3_KORCO
          Length = 384

 Score =  115 bits (287), Expect = 2e-24
 Identities = 65/138 (47%), Positives = 83/138 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G+ ++ + M+ER  L NM VEAG K  ++P D  T  YL G+   A
Sbjct: 152 IGVDGANYKALEFNGSILKVMEMDERFVLTNMSVEAGAKTAIIPVDDVTLSYLNGRLRRA 211

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
             P YSD  +    E   DVS LEPLVA PHSP N   A E  D +ID+ +IGSCTGG+ 
Sbjct: 212 PRPEYSDDGSH-SDEISIDVSSLEPLVAIPHSPANVKPASEV-DAEIDQAFIGSCTGGRL 269

Query: 361 EDFMAAAKIFLASGKTVK 414
           +D   AA+I    G+ VK
Sbjct: 270 KDLEVAARIL--RGRRVK 285

[127][TOP]
>UniRef100_A4XJ48 3-isopropylmalate dehydratase large subunit n=1
           Tax=Caldicellulosiruptor saccharolyticus DSM 8903
           RepID=LEUC_CALS8
          Length = 429

 Score =  115 bits (287), Expect = 2e-24
 Identities = 59/139 (42%), Positives = 85/139 (61%), Gaps = 1/139 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSME+ G  ++SL+M++R T+ NM +EAG KNG+   D  T +Y++  ++  
Sbjct: 188 IGVDGALYKSMEYTGEGLKSLSMDDRFTIANMAIEAGAKNGIFEVDEKTIEYVKQHSTKP 247

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD-VKIDRVYIGSCTGGK 357
           Y+   +D+ A +   Y  D+SK+ P VA PH P+N     E  + + ID+V IGSCT G+
Sbjct: 248 YKIFKADEDAEYSEVYEIDISKIRPTVAFPHLPENTKTIDEITEKIYIDQVVIGSCTNGR 307

Query: 358 TEDFMAAAKIFLASGKTVK 414
            ED   AAKI    G+ VK
Sbjct: 308 IEDLRIAAKIL--KGRKVK 324

[128][TOP]
>UniRef100_C7II84 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           papyrosolvens DSM 2782 RepID=C7II84_9CLOT
          Length = 419

 Score =  114 bits (286), Expect = 3e-24
 Identities = 54/129 (41%), Positives = 82/129 (63%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  V +L+M++R ++ NM +EAG KNG+   D  T +Y++  +  +
Sbjct: 186 IGVDGALYKSMEFTGDGVNALSMDDRFSMANMAIEAGAKNGIFEVDEKTVEYVKEHSIRS 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A++   Y  D+++++P VA PH P+N     +  D+KID+V IGSCT G+ 
Sbjct: 246 YTVYKADEDAQYSEVYEIDLAEIKPTVAFPHLPENARTIDKVGDIKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED   AA+I
Sbjct: 306 EDMRIAAQI 314

[129][TOP]
>UniRef100_B4WHZ3 3-isopropylmalate dehydratase, large subunit subfamily n=1
           Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ3_9SYNE
          Length = 567

 Score =  114 bits (286), Expect = 3e-24
 Identities = 59/127 (46%), Positives = 77/127 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GAT   +EF G+ VE L M+ERMTL NMV+E G   G++P D TT +Y++  T+  
Sbjct: 335 IGCHGATGTVVEFAGSVVEQLPMDERMTLANMVIECGAMCGLMPVDQTTREYVKAHTNQP 394

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +  V +D  A++   YRFD+S+L P VA P +PD      E   V I R +IGSCTGGK 
Sbjct: 395 FTEVTADLDAQYEQSYRFDLSQLTPQVAAPPTPDRVVPVHELDGVAITRAFIGSCTGGKL 454

Query: 361 EDFMAAA 381
            D  AAA
Sbjct: 455 HDLAAAA 461

[130][TOP]
>UniRef100_B4U7U5 3-isopropylmalate dehydratase large subunit n=1
           Tax=Hydrogenobaculum sp. Y04AAS1 RepID=LEUC_HYDS0
          Length = 424

 Score =  114 bits (286), Expect = 3e-24
 Identities = 56/137 (40%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G  + SL + +R+T+ NM +EAGGK+G++  D  T +Y+E +    
Sbjct: 185 IGVDGALYRAMEFDGEAIRSLDVSQRLTIANMAIEAGGKSGIISPDEKTIEYVEKRAKKP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   SD+ A ++  Y +D S +EP+VA P+ P N     E   + ID+ +IGSCT G+ 
Sbjct: 245 YKIYQSDKDAHYVEVYEWDASSIEPMVAWPYLPSNVHPVSESTHITIDQAFIGSCTNGRI 304

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA I    GK V
Sbjct: 305 EDLRIAASIL--KGKKV 319

[131][TOP]
>UniRef100_A0LMK9 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMK9_SYNFM
          Length = 419

 Score =  114 bits (285), Expect = 3e-24
 Identities = 57/129 (44%), Positives = 77/129 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++MEF G  ++ L M +R ++CNM +EAG K G++  D  T +Y++G+   +
Sbjct: 186 IGVDGARYRAMEFTGEVIDRLPMSDRFSMCNMAIEAGAKAGIIAPDPVTEEYVKGRAKRS 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE   SD  A F S + +DVS  EP+VA PHSP N           ID+V IGSCT G+ 
Sbjct: 246 YEFYRSDPDAAFESVHEWDVSAFEPMVALPHSPANVRPVSRIPRTVIDQVVIGSCTNGRY 305

Query: 361 EDFMAAAKI 387
           ED   AA I
Sbjct: 306 EDLETAAAI 314

[132][TOP]
>UniRef100_B8GJ01 Homoaconitate hydratase family protein n=1 Tax=Methanosphaerula
           palustris E1-9c RepID=B8GJ01_METPE
          Length = 419

 Score =  114 bits (285), Expect = 3e-24
 Identities = 56/129 (43%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATYK++EF G+T+  + M  RMTL NM +E GGK G+VP D  T+ YL+ +  V 
Sbjct: 186 IGADGATYKAVEFAGSTIRGMEMPGRMTLSNMAIEMGGKAGIVPPDQVTWDYLKSRRQVT 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
              + SD+ A F  + R+DV+ L P VA PH+ D+     E     +D+V+IGSCT G+ 
Sbjct: 246 PFELDSDEDATFADQRRYDVTNLVPKVAVPHNVDHVVDVTEVAGTHLDQVFIGSCTNGRF 305

Query: 361 EDFMAAAKI 387
           ED   AA +
Sbjct: 306 EDLAEAAAV 314

[133][TOP]
>UniRef100_A8ABG2 3-isopropylmalate dehydratase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8ABG2_IGNH4
          Length = 429

 Score =  114 bits (285), Expect = 3e-24
 Identities = 56/135 (41%), Positives = 87/135 (64%), Gaps = 2/135 (1%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEP- 189
           GATY S EFVG  ++ + ++ R+T+ NMVVE G K G++PAD    +++EG+     +P 
Sbjct: 188 GATYMSAEFVGDGLKDMRIDSRLTVSNMVVEMGAKVGLMPADEEVMRFVEGRARGVPKPE 247

Query: 190 -VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
             + D  A +  E+ +D+S++EP+VAKP+SP N     E + +++D+V+IGSCT G+ ED
Sbjct: 248 LTFPDPGAHYKDEFTYDLSEIEPMVAKPYSPANSVPVSEVEGIEVDQVFIGSCTNGRLED 307

Query: 367 FMAAAKIFLASGKTV 411
              AA+I    GK V
Sbjct: 308 VAVAARIL--KGKKV 320

[134][TOP]
>UniRef100_Q2LWJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Syntrophus
           aciditrophicus SB RepID=LEUC_SYNAS
          Length = 420

 Score =  114 bits (285), Expect = 3e-24
 Identities = 58/129 (44%), Positives = 75/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF G T+ SLTM +R T+ NM +EAGGKNG+   D  T  Y++ +    
Sbjct: 186 IGVDGALYKAMEFTGDTIASLTMADRFTIANMAIEAGGKNGIFTPDEITEAYVKPRAKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    SD  A +      DV+++EP VA PH P N     E   V +D+V IGSCT G+ 
Sbjct: 246 YTFYASDPDAAYAQVIEIDVNRIEPQVAFPHLPSNTKGISEVGQVPLDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED  AAA +
Sbjct: 306 EDLRAAAAV 314

[135][TOP]
>UniRef100_C1DUH4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium azorense Az-Fu1
           RepID=C1DUH4_SULAA
          Length = 431

 Score =  114 bits (284), Expect = 4e-24
 Identities = 57/137 (41%), Positives = 84/137 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+ME+ G  +++L ++ R+T+ NM +EAGGKN V+ AD  T +++  +T+  
Sbjct: 186 IGVDGALYKAMEYHGEAIKALDIDNRLTIANMAIEAGGKNAVIEADEKTIEWVRKRTNRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   SD  A++  EY FD +K+EP+VA P+ P N     E     ID+V+IGSCT G+ 
Sbjct: 246 FKIYKSDPDAKYCCEYEFDANKIEPVVACPNLPSNVKPVSEVAGTHIDQVFIGSCTNGRL 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA I    GK V
Sbjct: 306 SDLRIAAAIL--KGKKV 320

[136][TOP]
>UniRef100_B0A9M7 Putative uncharacterized protein n=1 Tax=Clostridium bartlettii DSM
           16795 RepID=B0A9M7_9CLOT
          Length = 429

 Score =  114 bits (284), Expect = 4e-24
 Identities = 62/134 (46%), Positives = 83/134 (61%), Gaps = 5/134 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG---KT 171
           I V GA Y SMEF G  V+ L+M++R T+CNM +EAG KNG+ P D  T +Y+E    KT
Sbjct: 186 IGVDGARYMSMEFAGDGVQYLSMDDRFTICNMAIEAGAKNGIFPVDEKTKEYMEAHPCKT 245

Query: 172 SVAYEPVY-SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE-CKDVKIDRVYIGSC 345
                 VY +D+ A +      D+S+L+P VA PH P+N     E  +D+KID+V IGSC
Sbjct: 246 IEKNPTVYEADEDAEYDRVIEIDLSELKPTVAFPHLPENTKTTDEITEDIKIDQVVIGSC 305

Query: 346 TGGKTEDFMAAAKI 387
           T G+ ED   AA+I
Sbjct: 306 TNGRIEDMRIAAEI 319

[137][TOP]
>UniRef100_O27668 3-isopropylmalate dehydratase large subunit 2 n=1
           Tax=Methanothermobacter thermautotrophicus str. Delta H
           RepID=LEUC2_METTH
          Length = 428

 Score =  114 bits (284), Expect = 4e-24
 Identities = 54/129 (41%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GATY+S+EF G T+ES+ +  RMT+CNM VE G KNG++  +  T  Y+  +T   
Sbjct: 190 IGVDGATYRSVEFTGDTIESMDVSGRMTICNMAVEMGAKNGIMEPNRQTLDYVRARTGRE 249

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +    SD+ +++L ++ FDVS LEP VA P   DN       +   ID  ++GSCT G+ 
Sbjct: 250 FRVYSSDEDSQYLEDHHFDVSDLEPQVACPDDVDNVYPVHRVEGTHIDEAFLGSCTNGRY 309

Query: 361 EDFMAAAKI 387
           ED   AA++
Sbjct: 310 EDLKIAAEV 318

[138][TOP]
>UniRef100_Q1Q122 Similar to 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q122_9BACT
          Length = 437

 Score =  113 bits (283), Expect = 6e-24
 Identities = 53/129 (41%), Positives = 75/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+MEF GT +  L M++R T+CNM +EAG K+G++  D  T  Y+ G+    
Sbjct: 193 IGVDGALYKAMEFTGTAISDLPMDDRFTICNMAIEAGAKSGIIAPDKITENYVAGRVKRE 252

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y   +SD  + +   Y F+  ++ P VA P  P+N     +   +KID+V IGSCT G+ 
Sbjct: 253 YVAYHSDPDSHYSKVYEFNAEEIVPQVALPSLPENTKSVYDVCGIKIDQVVIGSCTNGRI 312

Query: 361 EDFMAAAKI 387
            D   AAKI
Sbjct: 313 SDLRIAAKI 321

[139][TOP]
>UniRef100_C4V4K3 3-isopropylmalate dehydratase n=1 Tax=Selenomonas flueggei ATCC
           43531 RepID=C4V4K3_9FIRM
          Length = 420

 Score =  113 bits (283), Expect = 6e-24
 Identities = 57/130 (43%), Positives = 78/130 (60%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKS+EF G  V SL+M +R+T+ NM +EAG KNG+ P D     Y+EG+ +  
Sbjct: 185 IGVDGALYKSLEFTGEGVASLSMTDRLTIANMAIEAGAKNGIFPYDDVCRAYVEGRMTKP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC-KDVKIDRVYIGSCTGGK 357
           + PV +D  AR+      D+S L P+V+ PH P+N     +    + ID+V IGSCT G+
Sbjct: 245 FAPVAADADARYAQTVEIDLSALRPVVSFPHLPENTKRVMDIGAPIAIDQVVIGSCTNGR 304

Query: 358 TEDFMAAAKI 387
            ED   AA I
Sbjct: 305 LEDMEIAASI 314

[140][TOP]
>UniRef100_Q6LY44 3-isopropylmalate dehydratase n=1 Tax=Methanococcus maripaludis
           RepID=Q6LY44_METMP
          Length = 424

 Score =  113 bits (283), Expect = 6e-24
 Identities = 56/139 (40%), Positives = 81/139 (58%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG----- 165
           +   GATYK+ +F G TV+++T+  RMT+ NM +E GGK G++  D  T  Y++      
Sbjct: 185 VGADGATYKAAQFAGNTVDNMTIASRMTMSNMAIEMGGKAGLIAPDDKTINYVKNAMEAN 244

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T+  +E V  D+ A F  ++  DVS LEP++A PH+ DN    RE     ID+V+IGSC
Sbjct: 245 NTAKPFELVLGDKNAEFEEKFEIDVSNLEPVMACPHNVDNVKAVREVAGTPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED  AA  +    G
Sbjct: 305 TNGRLEDLRAALNVIEKHG 323

[141][TOP]
>UniRef100_B2TIQ9 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum B str. Eklund 17B RepID=LEUC_CLOBB
          Length = 419

 Score =  113 bits (283), Expect = 6e-24
 Identities = 59/138 (42%), Positives = 79/138 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL+  T   
Sbjct: 186 IGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDDKTVEYLKEHTKKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E   +D+ A +      +++ L P V+ PH PDN        D+ ID+V IGSCT G+ 
Sbjct: 246 WEVYKADEDAEYDEVIEIELNTLRPTVSFPHLPDNTRTIDNVGDIDIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTVK 414
            D   A  I    GK VK
Sbjct: 306 SDLRIARDIL--KGKKVK 321

[142][TOP]
>UniRef100_B9MLV4 3-isopropylmalate dehydratase large subunit n=1 Tax=Anaerocellum
           thermophilum DSM 6725 RepID=LEUC_ANATD
          Length = 429

 Score =  113 bits (283), Expect = 6e-24
 Identities = 58/139 (41%), Positives = 85/139 (61%), Gaps = 1/139 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSME+ G  ++SL+M++R T+ NM +EAG KNG+   D  T +Y++  ++  
Sbjct: 188 IGVDGALYKSMEYTGEGLKSLSMDDRFTIANMAIEAGAKNGIFEVDEKTIEYVKQHSTKP 247

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD-VKIDRVYIGSCTGGK 357
           Y+   +D+ A +   +  D+SK+ P VA PH P+N     E  + + ID+V IGSCT G+
Sbjct: 248 YKIFKADEDAEYSQVFEIDISKIRPTVAFPHLPENTKTIDEITEKIYIDQVVIGSCTNGR 307

Query: 358 TEDFMAAAKIFLASGKTVK 414
            ED   AAKI    G+ VK
Sbjct: 308 IEDLRIAAKIL--KGRKVK 324

[143][TOP]
>UniRef100_B8I2I1 Homoaconitate hydratase family protein n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I2I1_CLOCE
          Length = 418

 Score =  113 bits (282), Expect = 7e-24
 Identities = 57/129 (44%), Positives = 80/129 (62%), Gaps = 1/129 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + + GA Y  +EF G  +++L +  R+TLCNMV+E G K G++ AD+ T KY   K    
Sbjct: 185 LGINGANYDMLEFDGELIKNLDISSRLTLCNMVIEMGAKAGIINADAVTQKYFREKNLKT 244

Query: 181 YEPVY-SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            +  + SD  AR+      DVSK+EP++A P+SP N   A+E  D+KID+V IGSCT G+
Sbjct: 245 EDIDFNSDNGARYKKIIEIDVSKIEPVIACPYSPGNIKTAKELVDLKIDQVVIGSCTNGR 304

Query: 358 TEDFMAAAK 384
            EDF  A K
Sbjct: 305 IEDFRVAHK 313

[144][TOP]
>UniRef100_A4FX22 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanococcus
           maripaludis C5 RepID=A4FX22_METM5
          Length = 424

 Score =  113 bits (282), Expect = 7e-24
 Identities = 55/139 (39%), Positives = 82/139 (58%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG----- 165
           +   GATYK+ +F G TV+++T+  RMT+ NM +E GGK G++  D  T  Y++      
Sbjct: 185 VGADGATYKAAQFAGNTVDNMTIASRMTMSNMAIEMGGKAGLIAPDDKTINYVKNAMEMN 244

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T+  +E +  D+ A F  ++  DVS LEP++A PH+ DN    RE     ID+V+IGSC
Sbjct: 245 NTAKPFEFILGDKDAEFEKKFEIDVSNLEPVMACPHNVDNVKAVREVAGTPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED  AA ++    G
Sbjct: 305 TNGRLEDLRAALEVIEKHG 323

[145][TOP]
>UniRef100_B9L6Y8 3-isopropylmalate dehydratase large subunit n=1 Tax=Nautilia
           profundicola AmH RepID=LEUC_NAUPA
          Length = 425

 Score =  113 bits (282), Expect = 7e-24
 Identities = 66/146 (45%), Positives = 87/146 (59%), Gaps = 9/146 (6%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G  +E+L M++RM+LCNM +EAG KNG+V  D  T  +LE      
Sbjct: 185 IGVDGALYKALEFTGEVIENLPMDDRMSLCNMAIEAGAKNGIVAYDKITEAFLEEVKK-- 242

Query: 181 YEPV-------YSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECK-DVKIDRVY 333
           Y P+       YSD  A +      DV+KLEPLVA P  P N + +++  K D++ID+VY
Sbjct: 243 YNPLRSEPKIHYSDPDANYSQVIEIDVNKLEPLVAYPFLPSNGKPISQAVKDDIEIDQVY 302

Query: 334 IGSCTGGKTEDFMAAAKIFLASGKTV 411
           IGSCT G   D   AA+I    GK V
Sbjct: 303 IGSCTNGTLSDLRIAAEIL--KGKRV 326

[146][TOP]
>UniRef100_A7IA28 3-isopropylmalate dehydratase large subunit n=1 Tax=Candidatus
           Methanoregula boonei 6A8 RepID=LEUC_METB6
          Length = 416

 Score =  113 bits (282), Expect = 7e-24
 Identities = 52/129 (40%), Positives = 80/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY+++EF G T+  + M  RMT CNM +E G K G+VP D  T++Y++G+  + 
Sbjct: 183 IGADGATYQAIEFTGKTISKMDMAGRMTCCNMAIEMGAKAGIVPPDKVTWEYMKGRRKIT 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
              + SD  A+F  +  ++V+ LEP VA PH+ D      + +   ID+V+IGSCT G+ 
Sbjct: 243 PFALASDDDAKFAEKRTYNVADLEPQVAVPHNVDQGIPVGKVEGTHIDQVFIGSCTNGRY 302

Query: 361 EDFMAAAKI 387
           ED + AA++
Sbjct: 303 EDLVEAAEV 311

[147][TOP]
>UniRef100_B2UYH6 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum E3 str. Alaska E43 RepID=LEUC_CLOBA
          Length = 419

 Score =  113 bits (282), Expect = 7e-24
 Identities = 60/138 (43%), Positives = 79/138 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL+  T   
Sbjct: 186 IGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDDKTVEYLKEHTEKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D+ A +      D+S L+P V+ PH PDN         V ID+V IGSCT G+ 
Sbjct: 246 WKIYEADEDAEYDEVIEIDLSTLKPTVSFPHLPDNTRTIDNANRVNIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTVK 414
            D   A  I    GK VK
Sbjct: 306 SDLRIARGIL--KGKKVK 321

[148][TOP]
>UniRef100_A8EQZ0 3-isopropylmalate dehydratase large subunit n=1 Tax=Arcobacter
           butzleri RM4018 RepID=LEUC_ARCB4
          Length = 426

 Score =  113 bits (282), Expect = 7e-24
 Identities = 61/146 (41%), Positives = 92/146 (63%), Gaps = 8/146 (5%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYL----EGK 168
           + V GA YK++EF G T++ L+M++R +LCNM +EAG KNG+V  D  T ++L    E  
Sbjct: 185 LGVDGALYKALEFTGDTIQYLSMDDRFSLCNMAIEAGAKNGIVAYDEITKEFLDKVGEAN 244

Query: 169 TSVAYEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKD-VKIDRVYI 336
             +  EP   YSD+ A +      DV+KLEP++A P+ P N  ++++   D +K+D+V+I
Sbjct: 245 GGLRAEPKIHYSDEDANYCQVIEIDVAKLEPVIAYPYLPSNGHSVSQAVSDNIKVDQVFI 304

Query: 337 GSCTGGKTEDFMAAAKIFLASGKTVK 414
           GSCT G+  DF  AA+I LA  K  +
Sbjct: 305 GSCTNGRLSDFKIAAEI-LAGQKVAR 329

[149][TOP]
>UniRef100_Q9UZ07 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           abyssi RepID=LEUC1_PYRAB
          Length = 423

 Score =  113 bits (282), Expect = 7e-24
 Identities = 55/131 (41%), Positives = 85/131 (64%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK MEF G+ +E L++E+RMT+ NM +EAG K G++  D  T  Y++ +    
Sbjct: 186 IGVNGALYKVMEFSGSVIEELSVEQRMTMSNMAIEAGAKTGIIEPDKKTLDYVKERAKRK 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRA-LARECK-DVKIDRVYIGSCTGG 354
           ++   SD+ A++     +DV+  EP+VA PH P+N   +++  K ++KID+V+IGSCT G
Sbjct: 246 FKVYKSDEDAKYYKVIEYDVTNWEPVVAFPHLPENTVPISKAAKMNIKIDQVFIGSCTNG 305

Query: 355 KTEDFMAAAKI 387
           + ED   AA+I
Sbjct: 306 RIEDLRMAAEI 316

[150][TOP]
>UniRef100_C6PQI2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           carboxidivorans P7 RepID=C6PQI2_9CLOT
          Length = 421

 Score =  112 bits (281), Expect = 1e-23
 Identities = 54/130 (41%), Positives = 79/130 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSME+ G  +++L+M++R T+ NM +EAG KNG+   D  T +Y++  ++  
Sbjct: 186 IGVDGALYKSMEYTGEGLKNLSMDDRFTMANMAIEAGAKNGIFEVDDKTIEYVKEHSNRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +      D+S + P VA PH P+N     E  +V ID+  IGSCT G+ 
Sbjct: 246 YTVYTADEDAEYSKVIEIDLSSIRPTVAFPHLPENTRTIDEVGEVFIDQAVIGSCTNGRI 305

Query: 361 EDFMAAAKIF 390
           ED  AAAK+F
Sbjct: 306 EDLRAAAKVF 315

[151][TOP]
>UniRef100_B1C4Q4 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C4Q4_9FIRM
          Length = 424

 Score =  112 bits (280), Expect = 1e-23
 Identities = 61/140 (43%), Positives = 80/140 (57%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ LTM++R T+CNM +EAG KNG+ P D  T  Y+E  +   
Sbjct: 185 IGVDGALYKSMEFVGDGIQYLTMDDRFTICNMAIEAGAKNGIFPVDDQTIAYMEEHSKKD 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE---CKDVKIDRVYIGSCTG 351
           Y+   +D+ A +      D+SK+ P VA PH P N     E    + + ID+V IGSCT 
Sbjct: 245 YKVYTADEDAEYERVIEIDLSKVRPTVAFPHLPGNGHTIDEIEAMEPIYIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+  D   AA I    GK V
Sbjct: 305 GRISDLRKAAAIL--KGKKV 322

[152][TOP]
>UniRef100_A3DHI4 3-isopropylmalate dehydratase large subunit n=3 Tax=Clostridium
           thermocellum RepID=LEUC_CLOTH
          Length = 419

 Score =  112 bits (280), Expect = 1e-23
 Identities = 52/129 (40%), Positives = 80/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  V  L+M++R  + NM +EAG KNG+   D  T +Y++  ++  
Sbjct: 186 IGVDGALYRSMEFTGDGVAHLSMDDRFAMANMAIEAGAKNGIFEVDEKTIEYVKEHSTRQ 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   +D+ A +++ Y  D+S+++P VA PH P N        ++KID+V IGSCT G+ 
Sbjct: 246 YKVYKADEDAEYVATYEIDLSQVKPTVAFPHLPSNTRTIDNVGNIKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED   AA++
Sbjct: 306 EDLRVAAEV 314

[153][TOP]
>UniRef100_Q3Z894 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z894_DEHE1
          Length = 416

 Score =  112 bits (279), Expect = 2e-23
 Identities = 54/129 (41%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y +M F G  +++L+ME R T+ NM +EAGGK G+   D  T +Y+  +    
Sbjct: 183 IGVDGALYSAMYFCGEAIDALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQ 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D  A +   Y FD+SKLEP V+ PHSP N     +   +K+D+V IGSCT G+ 
Sbjct: 243 YTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPISQIGKIKVDQVIIGSCTNGRL 302

Query: 361 EDFMAAAKI 387
           ED   +AK+
Sbjct: 303 EDLAISAKL 311

[154][TOP]
>UniRef100_A5FR41 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FR41_DEHSB
          Length = 416

 Score =  112 bits (279), Expect = 2e-23
 Identities = 54/127 (42%), Positives = 75/127 (59%)
 Frame = +1

Query: 7   VAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYE 186
           V GA Y +M F G  +E+L+ME R T+ NM +EAGGK G+   D  T +Y+  +    Y 
Sbjct: 185 VDGALYSAMFFCGEAIEALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQYT 244

Query: 187 PVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
              +D  A +   Y FD+SKLEP V+ PHSP N     +   +K+D+V IGSCT G+ ED
Sbjct: 245 VYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPVSQIGKIKVDQVIIGSCTNGRLED 304

Query: 367 FMAAAKI 387
              +AK+
Sbjct: 305 LAVSAKL 311

[155][TOP]
>UniRef100_C5UT24 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           botulinum E1 str. 'BoNT E Beluga' RepID=C5UT24_CLOBO
          Length = 419

 Score =  112 bits (279), Expect = 2e-23
 Identities = 59/138 (42%), Positives = 79/138 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D+ T KYL+  T   
Sbjct: 186 IGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDNKTVKYLKEHTVKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   +D+ A +      +++ L P V+ PH PDN         V ID+V IGSCT G+ 
Sbjct: 246 WKVYKADEDAEYDEVIEIELNTLRPTVSFPHLPDNTRTIDNANGVDIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTVK 414
            D   A  I    GK VK
Sbjct: 306 SDLRIARDIL--KGKKVK 321

[156][TOP]
>UniRef100_C4FI11 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium yellowstonense SS-5
           RepID=C4FI11_9AQUI
          Length = 431

 Score =  112 bits (279), Expect = 2e-23
 Identities = 56/137 (40%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+ME+ G  +++L ++ R+T+ NM +EAGGK+G++  D  T +++  +T   
Sbjct: 186 IGVDGALYKAMEYHGEAIKALDIDNRLTIANMAIEAGGKSGIIEPDEKTVEWVRKRTDRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   SD  A++  EY FD SK+EP+VA P  P N     E     ID+V+IGSCT G+ 
Sbjct: 246 FKLYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTHIDQVFIGSCTNGRL 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA I    GK V
Sbjct: 306 SDLRIAAAIL--KGKKV 320

[157][TOP]
>UniRef100_A8CP51 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. VS RepID=A8CP51_9CHLR
          Length = 416

 Score =  112 bits (279), Expect = 2e-23
 Identities = 54/129 (41%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y +M F G  +++L+ME R T+ NM +EAGGK G+   D  T +Y+  +    
Sbjct: 183 IGVDGALYSAMYFCGEAIDALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQ 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D  A +   Y FD+SKLEP V+ PHSP N     +   +K+D+V IGSCT G+ 
Sbjct: 243 YTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPISQIGKIKVDQVIIGSCTNGRL 302

Query: 361 EDFMAAAKI 387
           ED   +AK+
Sbjct: 303 EDLAISAKL 311

[158][TOP]
>UniRef100_B5YKE0 3-isopropylmalate dehydratase large subunit n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=LEUC_THEYD
          Length = 421

 Score =  112 bits (279), Expect = 2e-23
 Identities = 52/129 (40%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA+Y +MEF+G  ++++ M  R ++CNM +EAG K G++  D  T +Y++ +    
Sbjct: 186 IGVDGASYMAMEFIGEVIDNMPMSGRFSMCNMAIEAGAKAGIIVPDKITEEYVKLRAKRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   SDQ A++     +D S++ P+VA PH P N   A E   +KID+V IGSCT G+ 
Sbjct: 246 YKIYNSDQDAKYFEIKEYDCSRIPPVVACPHLPSNVKPANELSHIKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
           ED   AA +
Sbjct: 306 EDLREAAMV 314

[159][TOP]
>UniRef100_A0RMG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           fetus subsp. fetus 82-40 RepID=LEUC_CAMFF
          Length = 421

 Score =  112 bits (279), Expect = 2e-23
 Identities = 62/141 (43%), Positives = 87/141 (61%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G  ++ L M+ R +LCNM +EAGGK+G++  D  T ++LE K ++ 
Sbjct: 185 IGVDGALYKALEFCGDAMKYLDMDSRFSLCNMAIEAGGKSGIIAVDDITKEFLESK-NLR 243

Query: 181 YEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVYIGSCT 348
            +P   YSD+ A +    R DVSKL+P++A P  P N     E    D+KID+V+IGSCT
Sbjct: 244 SKPKFHYSDEGANYEQVLRIDVSKLDPVIAYPFLPSNGKSINEALKDDLKIDQVFIGSCT 303

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   AA+I    GK V
Sbjct: 304 NGRLSDLRIAARIL--KGKRV 322

[160][TOP]
>UniRef100_C4CHB6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CHB6_9CHLR
          Length = 418

 Score =  111 bits (278), Expect = 2e-23
 Identities = 58/129 (44%), Positives = 74/129 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y  MEF G  +++L M+ R+ + NM +EAG K G+   D  T ++L   T   
Sbjct: 184 IGVDGALYAVMEFTGEVIDALDMDGRIAMANMAIEAGAKTGIFACDDKTREWLARVTDRP 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YEPV SD  A +L    FDVS L+P+VA PH P N   A E  D+ I +V IGSCT G+ 
Sbjct: 244 YEPVESDPDAEYLKVIEFDVSNLKPVVALPHLPSNVYPADEVGDMPIHQVVIGSCTNGRI 303

Query: 361 EDFMAAAKI 387
            D    AKI
Sbjct: 304 SDLREVAKI 312

[161][TOP]
>UniRef100_C0B4W1 Putative uncharacterized protein n=1 Tax=Coprococcus comes ATCC
           27758 RepID=C0B4W1_9FIRM
          Length = 417

 Score =  111 bits (278), Expect = 2e-23
 Identities = 53/139 (38%), Positives = 79/139 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           +   G  Y+ MEF G   ++LT+ +R+ LCNM VEAG K G+   D    +YL+      
Sbjct: 184 VGANGCNYQVMEFTGEGAKTLTISDRIALCNMAVEAGAKTGIFEVDDVAMEYLKEHGREP 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
               +SD  A ++ EY FD+SK+EP+VAKP   DN A A++ + +KID  ++GSC  G+ 
Sbjct: 244 KAVYHSDPDAHYVREYTFDLSKVEPVVAKPDFVDNLAPAKDVRGIKIDEAFLGSCNNGRI 303

Query: 361 EDFMAAAKIFLASGKTVKV 417
           ED    A++      + KV
Sbjct: 304 EDLRVGAQVIKGKKVSEKV 322

[162][TOP]
>UniRef100_Q18AJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile 630 RepID=LEUC_CLOD6
          Length = 425

 Score =  111 bits (278), Expect = 2e-23
 Identities = 64/142 (45%), Positives = 84/142 (59%), Gaps = 5/142 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG-KTSV 177
           I V GA YKSMEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+   K S 
Sbjct: 186 IGVDGALYKSMEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYINSHKCST 245

Query: 178 AYEPV---YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC-KDVKIDRVYIGSC 345
             + V    +D+ A +   Y  D++KL+  VA PH P+N     E  KD+KID+V IGSC
Sbjct: 246 MTKDVNIYEADEDAVYDEVYEIDLAKLKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSC 305

Query: 346 TGGKTEDFMAAAKIFLASGKTV 411
           T G+  D    A+I    GK V
Sbjct: 306 TNGRISDLEVVAEIM--KGKKV 325

[163][TOP]
>UniRef100_Q3ZXI5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. CBDB1 RepID=Q3ZXI5_DEHSC
          Length = 416

 Score =  111 bits (277), Expect = 3e-23
 Identities = 53/127 (41%), Positives = 75/127 (59%)
 Frame = +1

Query: 7   VAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYE 186
           V GA Y +M F G  +E+L+ME R T+ NM +EAGGK G+   D  T +Y+  +    Y 
Sbjct: 185 VDGALYSAMFFCGEAIEALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQYT 244

Query: 187 PVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTED 366
              +D  A +   Y FD+SK+EP V+ PHSP N     +   +K+D+V IGSCT G+ ED
Sbjct: 245 VYDNDADASYAKTYNFDISKIEPQVSLPHSPANARPVSQIGKIKVDQVIIGSCTNGRLED 304

Query: 367 FMAAAKI 387
              +AK+
Sbjct: 305 LAVSAKL 311

[164][TOP]
>UniRef100_A6DDD6 3-ISOPROPYLMALATE DEHYDRATASE, LARGE SUBUNIT n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDD6_9PROT
          Length = 425

 Score =  111 bits (277), Expect = 3e-23
 Identities = 63/146 (43%), Positives = 84/146 (57%), Gaps = 9/146 (6%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G T+E+L M++RM+LCNMV+EAG KNG++  D  T  +LE      
Sbjct: 185 IGVDGALYKALEFTGDTIENLPMDDRMSLCNMVIEAGAKNGIIAYDKITESFLEEVKK-- 242

Query: 181 YEPV-------YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVY 333
           + P+       YSD  A+++     DV  LEP+VA P+ P N     E    D++I +VY
Sbjct: 243 HNPLRSTPKIHYSDPDAKYVKIIEIDVDNLEPMVAYPYLPSNGKPISEAVKDDIEIHQVY 302

Query: 334 IGSCTGGKTEDFMAAAKIFLASGKTV 411
           IGSCT G   D   AA I    GK V
Sbjct: 303 IGSCTNGTLSDLRTAANIL--KGKRV 326

[165][TOP]
>UniRef100_A6BFK8 Putative uncharacterized protein n=1 Tax=Dorea longicatena DSM
           13814 RepID=A6BFK8_9FIRM
          Length = 424

 Score =  111 bits (277), Expect = 3e-23
 Identities = 61/140 (43%), Positives = 81/140 (57%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++L+M +R T+ NM +EAG KNG+ P D  T +YL+  T   
Sbjct: 185 IGVDGALYKSMEFTGDGIKNLSMADRFTMANMAIEAGAKNGIFPVDEKTEEYLKEHTKKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE---CKDVKIDRVYIGSCTG 351
           Y+   +D  A + S    D+S++ P VA PH P N     E    + +KID+V IGSCT 
Sbjct: 245 YKVYEADGDAEYESVVEIDLSEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+ ED   AA I    G TV
Sbjct: 305 GRMEDMRKAAAIL--QGHTV 322

[166][TOP]
>UniRef100_B1H0A6 3-isopropylmalate dehydratase large subunit n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=LEUC_UNCTG
          Length = 420

 Score =  111 bits (277), Expect = 3e-23
 Identities = 59/137 (43%), Positives = 77/137 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y SMEF G   + LTM +R T+ NM +EAGGKNG+   D  T  Y+  +    
Sbjct: 186 IGVDGALYNSMEFDGPLCKKLTMADRFTITNMAIEAGGKNGIFTPDEITENYVAKRAQRK 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   SD+ A++L  Y  D SK+ P V+ P  P N    ++ K   ID+V IGSCT G+ 
Sbjct: 246 YKFYISDKDAKYLKIYEIDCSKILPQVSMPFLPSNTKAVKDIKKTYIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA I +  GK V
Sbjct: 306 EDLRVAASI-IKKGKKV 321

[167][TOP]
>UniRef100_B2V844 3-isopropylmalate dehydratase large subunit n=1
           Tax=Sulfurihydrogenibium sp. YO3AOP1 RepID=LEUC_SULSY
          Length = 431

 Score =  111 bits (277), Expect = 3e-23
 Identities = 53/129 (41%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK+ME+ G  + +L ++ R+T+ NM +EAGGK+G++  D  T  ++  +T+  
Sbjct: 186 IGVDGALYKAMEYQGEAIRALDIDNRLTIANMAIEAGGKSGIIEPDEKTVDWVRKRTNRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++   SD  A++  EY FD SK+EP+VA P  P N     E     ID+V+IGSCT G+ 
Sbjct: 246 FKLYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTHIDQVFIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 306 SDLRIAAAI 314

[168][TOP]
>UniRef100_B8FMM4 3-isopropylmalate dehydratase large subunit n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=LEUC_DESAA
          Length = 419

 Score =  111 bits (277), Expect = 3e-23
 Identities = 57/131 (43%), Positives = 83/131 (63%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y +MEF G  +++L M ER+T+ NM +EAGGK G++  D+ T +Y +G+  V 
Sbjct: 186 IGVDGALYMAMEFTGEVIDALPMAERLTMANMAIEAGGKAGIIAPDAKTKEYADGR--VI 243

Query: 181 YEPVY--SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
            +PV+  SD  A++     +DV+ LEP VA PH P+N     +  +V I +V IGSCT G
Sbjct: 244 RKPVFYASDPDAKYAKVIEYDVTDLEPQVAFPHLPENTRPISQVGEVPIHQVIIGSCTNG 303

Query: 355 KTEDFMAAAKI 387
           + ED  +AA+I
Sbjct: 304 RIEDMRSAARI 314

[169][TOP]
>UniRef100_C0QS35 3-isopropylmalate dehydratase, large subunit n=1 Tax=Persephonella
           marina EX-H1 RepID=C0QS35_PERMH
          Length = 428

 Score =  110 bits (276), Expect = 4e-23
 Identities = 53/129 (41%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y++ME+ G  +++L +E R+T+ NM +EAGGKN ++ AD    ++L+ KT   
Sbjct: 186 IGVDGALYRAMEYHGEAIQALDVENRLTIANMAIEAGGKNAIMEADEKVLEWLKDKTDRP 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
              + +D  A++  EY FD SK+EP+VA P+ P N     E     I++V+IGSCT G+ 
Sbjct: 246 LRMLKADPDAKYCCEYEFDASKIEPVVAAPNLPSNVKPVTEVAGKPINQVFIGSCTNGRM 305

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 306 SDLRIAAHI 314

[170][TOP]
>UniRef100_B8I4G0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I4G0_CLOCE
          Length = 419

 Score =  110 bits (276), Expect = 4e-23
 Identities = 53/129 (41%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  V +L+M++R ++ NM +EAG KNG+   D  T +Y++  +   
Sbjct: 186 IGVDGALYKSMEFTGDGVNALSMDDRFSMANMAIEAGAKNGIFEVDEKTVEYVKEHSIRH 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +   Y  D+++++P VA PH P+N        D+KID+V IGSCT G+ 
Sbjct: 246 YTVYKADEDAEYSEVYEIDLAEVKPTVAFPHLPENARTIDNVGDIKIDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED   AA +
Sbjct: 306 EDMRIAAGV 314

[171][TOP]
>UniRef100_C9L6F6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Blautia
           hansenii DSM 20583 RepID=C9L6F6_RUMHA
          Length = 425

 Score =  110 bits (276), Expect = 4e-23
 Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKS+EF G  V++L+M++R T+ NM +EAG KNG+ P D  T +Y++  +   
Sbjct: 189 IGVDGALYKSLEFTGEGVKNLSMDDRFTIANMAIEAGAKNGIFPVDEKTEEYMKEHSKRP 248

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECK-DVKIDRVYIGSCTGGK 357
           Y+    D+ A +  EY  D+SKL P VA PH P N     E + DV I +  IGSCT G+
Sbjct: 249 YKRYEPDEDAVYDEEYTIDLSKLRPTVAFPHLPSNTKTIDEIQDDVIIQQSVIGSCTNGR 308

Query: 358 TEDFMAAAKI 387
            +D   AA+I
Sbjct: 309 IDDLRCAAQI 318

[172][TOP]
>UniRef100_B1C9W1 Putative uncharacterized protein n=1 Tax=Anaerofustis
           stercorihominis DSM 17244 RepID=B1C9W1_9FIRM
          Length = 424

 Score =  110 bits (276), Expect = 4e-23
 Identities = 56/141 (39%), Positives = 80/141 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  ++ L+M++R ++ NM +EAG KNG+ P D  T +Y +  ++  
Sbjct: 186 IGVDGALYRSMEFTGDGIKYLSMDDRFSMANMAIEAGAKNGIFPVDDKTIEYAKEHSTKT 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E   +D+ A++      D+SKL P V+ PH P+N     E   V ID+  IGSCT G+ 
Sbjct: 246 FEVFEADEDAQYDEVIEIDLSKLRPTVSFPHLPENTKTVDEAGKVYIDQAVIGSCTNGRL 305

Query: 361 EDFMAAAKIFLASGKTVKVPT 423
           ED   AA I        KV T
Sbjct: 306 EDIKMAADILRGKQVDKKVRT 326

[173][TOP]
>UniRef100_C8SBC1 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SBC1_FERPL
          Length = 427

 Score =  110 bits (276), Expect = 4e-23
 Identities = 54/130 (41%), Positives = 79/130 (60%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYL-EGKTSV 177
           + V GATYK++EF G T++ L M+ R+T+ NM +E G K G+  +D  T K+L E     
Sbjct: 192 LGVDGATYKALEFHGETIDKLDMDSRLTIANMAIECGAKAGLFKSDEVTKKFLMERGRGD 251

Query: 178 AYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            +  +  D+ A +  E  FDVS L P+VAKPH  DN A   E + VK+D+V++G+CT G+
Sbjct: 252 KFREIKPDEDAEYEKEMYFDVSDLTPIVAKPHQVDNIARIDEVEGVKVDQVFVGTCTNGR 311

Query: 358 TEDFMAAAKI 387
             D    A+I
Sbjct: 312 LSDLEVVARI 321

[174][TOP]
>UniRef100_C8PKG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           gracilis RM3268 RepID=C8PKG7_9PROT
          Length = 421

 Score =  110 bits (275), Expect = 5e-23
 Identities = 59/133 (44%), Positives = 83/133 (62%), Gaps = 4/133 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G  +E L M+ R +LCNM +EAGGK+G+V  D  T ++L  K ++ 
Sbjct: 185 IGVDGARYKALEFCGDALEYLDMDSRFSLCNMAIEAGGKSGIVAVDEITKEFLADK-NLR 243

Query: 181 YEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVYIGSCT 348
            EP   YSD+ A +    + DVSKL+P++A P  P N    RE    D+ +D+V+IGSCT
Sbjct: 244 AEPKFHYSDEGANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVRDDIAVDQVFIGSCT 303

Query: 349 GGKTEDFMAAAKI 387
            G+  D   AA+I
Sbjct: 304 NGRLSDLRIAAQI 316

[175][TOP]
>UniRef100_C3RJS7 Putative uncharacterized protein n=1 Tax=Mollicutes bacterium D7
           RepID=C3RJS7_9MOLU
          Length = 422

 Score =  110 bits (275), Expect = 5e-23
 Identities = 60/140 (42%), Positives = 78/140 (55%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ LTM++R T+CNM +EAG KNG+ P D  T  Y+E  +   
Sbjct: 183 IGVDGARYKSMEFVGEGIQHLTMDDRFTICNMAIEAGAKNGIFPVDEQTIAYMEKHSVKE 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECK---DVKIDRVYIGSCTG 351
           Y    +D+ A +      D+ K+ P VA PH P N     E +    + ID+V IGSCT 
Sbjct: 243 YAVYEADEDAEYDEVIEIDLGKVRPTVAFPHLPGNGHTIDEIEAMDKIMIDQVVIGSCTN 302

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+  D   AA I    GK V
Sbjct: 303 GRLSDLRKAAAIL--KGKQV 320

[176][TOP]
>UniRef100_B0N943 Putative uncharacterized protein n=1 Tax=Clostridium ramosum DSM
           1402 RepID=B0N943_9FIRM
          Length = 424

 Score =  110 bits (275), Expect = 5e-23
 Identities = 60/140 (42%), Positives = 78/140 (55%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  ++ LTM++R T+CNM +EAG KNG+ P D  T  Y+E  +   
Sbjct: 185 IGVDGARYKSMEFVGEGIQHLTMDDRFTICNMAIEAGAKNGIFPVDEQTIAYMEKHSVKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECK---DVKIDRVYIGSCTG 351
           Y    +D+ A +      D+ K+ P VA PH P N     E +    + ID+V IGSCT 
Sbjct: 245 YAVYEADEDAEYDEVIEIDLGKVRPTVAFPHLPGNGHTIDEIEAMDKIMIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+  D   AA I    GK V
Sbjct: 305 GRLSDLRKAAAIL--KGKQV 322

[177][TOP]
>UniRef100_A6NUW5 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6NUW5_9BACE
          Length = 422

 Score =  110 bits (275), Expect = 5e-23
 Identities = 55/129 (42%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKS+EF G  V+ L M++R T+ NM +EAGGKNG+ P D  T  YL G+ +  
Sbjct: 186 IGVDGALYKSLEFGGEGVKELAMDDRFTISNMAIEAGGKNGIFPVDDVTRAYLNGRVTRE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E   +D  A +  E   D+ +L P VA PH P N     + + + I +V IGSCT G+ 
Sbjct: 246 WEAFEADPDAVYEREVVIDLDQLRPTVALPHLPSNTRTVDQVEGMPIQQVVIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
           +D   AA+I
Sbjct: 306 KDIKEAAEI 314

[178][TOP]
>UniRef100_A5KNQ3 Putative uncharacterized protein n=1 Tax=Ruminococcus torques ATCC
           27756 RepID=A5KNQ3_9FIRM
          Length = 451

 Score =  110 bits (275), Expect = 5e-23
 Identities = 61/140 (43%), Positives = 79/140 (56%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  + +L+M++R T+ NM +EAG KNG+ P D  T +YL+      
Sbjct: 192 IGVDGALYKSMEFTGDGIGNLSMDDRFTMANMAIEAGAKNGIFPVDEKTVEYLDAHCEKP 251

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC---KDVKIDRVYIGSCTG 351
           Y    +D+ A +      D+SK+ P VA PH P N     E    + VKID+V IGSCT 
Sbjct: 252 YTVYEADEDAVYDDVVEIDLSKVRPTVAFPHLPGNAKTIDEIEAEEQVKIDQVVIGSCTN 311

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+ ED   AA I    G TV
Sbjct: 312 GRMEDMRKAAAIL--KGHTV 329

[179][TOP]
>UniRef100_A2SR25 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanocorpusculum labreanum Z RepID=A2SR25_METLZ
          Length = 392

 Score =  110 bits (275), Expect = 5e-23
 Identities = 51/129 (39%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GATY+++EF G     + +  RMT  NM +E G K G+VP D  T++Y+ G+T V 
Sbjct: 159 IGADGATYRALEFCGNAFSEMDIPGRMTCANMAIEMGAKAGIVPPDEKTWEYMRGRTEVT 218

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
              + SD+ A F     +D++K+ P +A PH+ DN     E     +D+V+IGSCT G+ 
Sbjct: 219 PFSLASDEDAVFFETRNYDIAKINPKIAVPHNVDNVVDVTEVAGKPVDQVFIGSCTNGRY 278

Query: 361 EDFMAAAKI 387
           EDF  AA++
Sbjct: 279 EDFAEAAEV 287

[180][TOP]
>UniRef100_UPI00016C5FE1 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile QCD-97b34 RepID=UPI00016C5FE1
          Length = 425

 Score =  110 bits (274), Expect = 6e-23
 Identities = 63/142 (44%), Positives = 84/142 (59%), Gaps = 5/142 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG-KTSV 177
           I V GA YKSMEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+   K S 
Sbjct: 186 IGVDGALYKSMEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYINSHKCST 245

Query: 178 AYEPV---YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC-KDVKIDRVYIGSC 345
             + V    +D+ A +   Y  D+++L+  VA PH P+N     E  KD+KID+V IGSC
Sbjct: 246 ITKDVNIYEADEDAVYDEVYEIDLAELKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSC 305

Query: 346 TGGKTEDFMAAAKIFLASGKTV 411
           T G+  D    A+I    GK V
Sbjct: 306 TNGRISDLEVVAEIM--KGKKV 325

[181][TOP]
>UniRef100_C9XME3 3-isopropylmalate dehydratase large subunit n=2 Tax=Clostridium
           difficile RepID=C9XME3_CLODI
          Length = 364

 Score =  110 bits (274), Expect = 6e-23
 Identities = 63/142 (44%), Positives = 84/142 (59%), Gaps = 5/142 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG-KTSV 177
           I V GA YKSMEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+   K S 
Sbjct: 125 IGVDGALYKSMEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYINSHKCST 184

Query: 178 AYEPV---YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC-KDVKIDRVYIGSC 345
             + V    +D+ A +   Y  D+++L+  VA PH P+N     E  KD+KID+V IGSC
Sbjct: 185 ITKDVNIYEADEDAVYDEVYEIDLAELKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSC 244

Query: 346 TGGKTEDFMAAAKIFLASGKTV 411
           T G+  D    A+I    GK V
Sbjct: 245 TNGRISDLEVVAEIM--KGKKV 264

[182][TOP]
>UniRef100_C4GAI7 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4GAI7_9FIRM
          Length = 434

 Score =  110 bits (274), Expect = 6e-23
 Identities = 55/132 (41%), Positives = 81/132 (61%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLE---GKT 171
           I V GA Y+SMEF G  ++ L+M++R T+ NM +E G KNG+ P D  T  Y++    + 
Sbjct: 200 IGVDGARYQSMEFDGEGIQYLSMDDRFTIANMAIEGGAKNGIFPVDDQTLAYIKEHADRK 259

Query: 172 SVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTG 351
            + YE   +D  A + +EY  D+S L+P V+ PH P+N     + +D+ ID+V IGSCT 
Sbjct: 260 PLVYE---ADADADYAAEYTIDLSSLKPTVSFPHLPENTRTIDQIEDIAIDQVVIGSCTN 316

Query: 352 GKTEDFMAAAKI 387
           G+  D  AAA+I
Sbjct: 317 GRLSDLKAAAEI 328

[183][TOP]
>UniRef100_C0C2K0 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0C2K0_9CLOT
          Length = 417

 Score =  110 bits (274), Expect = 6e-23
 Identities = 56/124 (45%), Positives = 71/124 (57%)
 Frame = +1

Query: 10  AGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEP 189
           AGATY S+E+ G T+  L ++ERM + NM VE G K G++P D  T  YL+      YEP
Sbjct: 188 AGATYMSVEYDGQTIRGLPVDERMAITNMAVEMGAKAGLMPFDDITEAYLDSIGVKDYEP 247

Query: 190 VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDF 369
             SD  A F   Y+F   +L P VA PH  D    A   +DVKI + Y+GSCTGG+  D 
Sbjct: 248 YQSDADASFYRTYQFRAEELRPQVACPHEVDRVTEADNVRDVKIQQAYLGSCTGGRLHDL 307

Query: 370 MAAA 381
             AA
Sbjct: 308 KTAA 311

[184][TOP]
>UniRef100_A6VG92 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C7 RepID=A6VG92_METM7
          Length = 424

 Score =  110 bits (274), Expect = 6e-23
 Identities = 53/139 (38%), Positives = 81/139 (58%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG----- 165
           +   GATYK+ +F G TV+++T+  RM++ NM +E GGK G++  D  T  Y++      
Sbjct: 185 VGADGATYKAAQFAGNTVDNMTIASRMSMSNMAIEMGGKAGLIAPDDKTINYVKNAMETN 244

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T+  +E +  D+ A F  ++  +V  LEP++A PH+ DN    RE     ID+V+IGSC
Sbjct: 245 NTAKPFEFILGDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKTVREVAGTPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED  AA K+    G
Sbjct: 305 TNGRIEDLRAALKVIEKHG 323

[185][TOP]
>UniRef100_C6PDK3 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571
           RepID=C6PDK3_CLOTS
          Length = 418

 Score =  109 bits (273), Expect = 8e-23
 Identities = 56/137 (40%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  + SL++++R T+ NM +EAG KNG+   D  T  Y++G+ +  
Sbjct: 185 IGVDGALYKSMEFTGD-ISSLSIDDRFTIANMAIEAGAKNGIFDYDEITETYVKGRANRK 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   +D+ A ++  Y  D+SK++P VA PH P+N     E  ++KID+V IGSCT G+ 
Sbjct: 244 YKVFKADKDADYVESYDIDLSKIKPQVAFPHLPENTKPIDEVGNIKIDQVVIGSCTNGRI 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D     ++    GK V
Sbjct: 304 SDMEVTYEVL--KGKKV 318

[186][TOP]
>UniRef100_C5ZZ28 3-isopropylmalate dehydratase, large subunit n=1 Tax=Helicobacter
           canadensis MIT 98-5491 RepID=C5ZZ28_9HELI
          Length = 421

 Score =  109 bits (273), Expect = 8e-23
 Identities = 56/141 (39%), Positives = 91/141 (64%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+++EF G  ++ L+M++R +LCNM +EAG KNG++ +D  T ++L  +  + 
Sbjct: 185 IGVDGALYQTLEFCGDGIQYLSMDDRFSLCNMAIEAGAKNGIIASDEITREFLASRKELR 244

Query: 181 YEP--VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECK-DVKIDRVYIGSCT 348
            +P   YSD+ A +    + D+S LEP++A P  P N +++++  K D+KID+V+IGSCT
Sbjct: 245 AKPKEFYSDKDANYTRVLKIDISTLEPVIAYPFLPSNGKSISQALKDDLKIDQVFIGSCT 304

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   A++I    GK V
Sbjct: 305 NGRLADLKIASEIL--KGKKV 323

[187][TOP]
>UniRef100_A1HUD1 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HUD1_9FIRM
          Length = 419

 Score =  109 bits (273), Expect = 8e-23
 Identities = 54/129 (41%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I  AGATYK MEF G+ +E+L+++ERMT+ NM VEAG K G++  D   + YLE   +  
Sbjct: 185 IGQAGATYKVMEFAGSCIENLSVDERMTIANMAVEAGAKTGLMAPDDKVFAYLESIGAPK 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
             P+YSD  A +  ++ F+   L P +A PH  D      E +   I + Y+GSCT G+ 
Sbjct: 245 GTPLYSDPDAEYAQKFEFNADTLVPQIALPHEVDKVVDITEAEGEVIHQAYLGSCTNGRY 304

Query: 361 EDFMAAAKI 387
            D + AAKI
Sbjct: 305 PDLVEAAKI 313

[188][TOP]
>UniRef100_A1HRB9 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HRB9_9FIRM
          Length = 420

 Score =  109 bits (273), Expect = 8e-23
 Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK-TSV 177
           I  AGATYK++E+VG  + +L ++ERM + NM VE G K G++  D+   +YL+ +  + 
Sbjct: 185 IGHAGATYKAVEYVGDAITNLCLDERMAITNMAVEMGAKAGLMAPDTKVVEYLKARGITE 244

Query: 178 AYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            Y    SD  A F + YRFD S+LEP+VA PH  DN       K   I + YIGSCTGG+
Sbjct: 245 GYTLFASDSDAVFCATYRFDASELEPVVACPHEVDNVTELSNVKGQVIHQAYIGSCTGGR 304

Query: 358 TEDFMAAAKI 387
             D  AAA++
Sbjct: 305 YNDLAAAARV 314

[189][TOP]
>UniRef100_A5UMS7 3-isopropylmalate dehydratase, large subunit, LeuC n=1
           Tax=Methanobrevibacter smithii ATCC 35061
           RepID=A5UMS7_METS3
          Length = 415

 Score =  109 bits (273), Expect = 8e-23
 Identities = 60/137 (43%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V G+TYK+ EF G TV ++++ +RM L NM +E GGK G+V  D  T  Y+E +++ A
Sbjct: 185 VGVDGSTYKACEFAGETVSNMSISDRMVLTNMAIEMGGKTGLVEPDKKTIDYVESRSNKA 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   +D  A  L+    DVS+LEP VA PH  DN     E  D +ID+V++GSCT G+ 
Sbjct: 245 YKVFKTDLDAPSLNIIDIDVSELEPQVACPHHVDNVKAVSEV-DQEIDQVFLGSCTNGRI 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AAKI    GK V
Sbjct: 304 SDLRDAAKIL--KGKKV 318

[190][TOP]
>UniRef100_Q1AVC5 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Rubrobacter
           xylanophilus DSM 9941 RepID=LEUC2_RUBXD
          Length = 424

 Score =  109 bits (273), Expect = 8e-23
 Identities = 52/129 (40%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V G     +EFVG    SL++++R+ + NM VEAG + G+ PAD  T +YL+ +    
Sbjct: 185 IGVGGGANAVLEFVGEGAASLSLDDRLAVANMAVEAGAETGIFPADEVTARYLDRRADRE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           + P  SD  A ++ + + D++ LEPLVA PHSP N     E +  KID+VYIG+C+ G  
Sbjct: 245 WHPERSDPDASYVRKVKIDLNSLEPLVALPHSPGNVVAVSEARGTKIDQVYIGNCSNGTI 304

Query: 361 EDFMAAAKI 387
            D    A+I
Sbjct: 305 TDLRQTAEI 313

[191][TOP]
>UniRef100_C5F2A2 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           pullorum MIT 98-5489 RepID=C5F2A2_9HELI
          Length = 422

 Score =  109 bits (272), Expect = 1e-22
 Identities = 57/141 (40%), Positives = 89/141 (63%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+++EF G  ++ L M++R +LCNM +EAG KNG++  D  T ++L+ +  + 
Sbjct: 185 IGVDGALYQTLEFCGEGIKYLGMDDRFSLCNMAIEAGAKNGIIAPDEITREFLKSRPFLR 244

Query: 181 YEP--VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECK-DVKIDRVYIGSCT 348
             P   YSD  A +    + D+SKLEP++A P  P N +++++  K D+KID+V+IGSCT
Sbjct: 245 ANPREFYSDADANYTQTIQIDISKLEPVIAYPFLPSNGKSISQALKDDLKIDQVFIGSCT 304

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   A++I    GK V
Sbjct: 305 NGRLSDLKIASEIL--KGKKV 323

[192][TOP]
>UniRef100_C4CQ67 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CQ67_9CHLR
          Length = 424

 Score =  109 bits (272), Expect = 1e-22
 Identities = 56/129 (43%), Positives = 72/129 (55%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V G T   +EFVG    +LT++ER+ + NM VEAG + G+ PAD  T  YL G+T   
Sbjct: 185 IGVGGGTNTVLEFVGPGAAALTIDERLAVANMAVEAGAETGLFPADEVTAAYLAGRTDRP 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++P  SD  A F    R D+  + PL+A PHSP N     E    KID+VYIG+C  G  
Sbjct: 245 WQPERSDPDASFARRVRIDLDGVPPLIALPHSPGNVVPVAEAAGRKIDQVYIGNCANGTM 304

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 305 TDLRQAASI 313

[193][TOP]
>UniRef100_B0G7V2 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G7V2_9FIRM
          Length = 425

 Score =  109 bits (272), Expect = 1e-22
 Identities = 56/132 (42%), Positives = 76/132 (57%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  + +L+M++R T+ NM +EAG KNG+ P D  T +YL   T   
Sbjct: 185 IGVDGALYKSMEFTGDGIANLSMDDRFTMANMAIEAGAKNGIFPVDDKTIQYLNEHTKKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE---CKDVKIDRVYIGSCTG 351
           Y    +D+ A +      D++++ P VA PH P N     E    + +KID+V IGSCT 
Sbjct: 245 YTVYEADEDAEYEQVVEIDLAEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKI 387
           G+ ED   AA I
Sbjct: 305 GRMEDMRKAAAI 316

[194][TOP]
>UniRef100_Q0W0U0 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W0U0_UNCMA
          Length = 418

 Score =  109 bits (272), Expect = 1e-22
 Identities = 60/143 (41%), Positives = 88/143 (61%), Gaps = 2/143 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLE--GKTS 174
           I+  GATY SMEF+G TV+++++E R+ + NM +EAGGK G+  AD    ++L   G+  
Sbjct: 184 ITADGATYMSMEFMGDTVKNMSVESRLVMSNMAIEAGGKVGLCAADEKVRQFLAKYGREH 243

Query: 175 VAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
             Y+P+ +D  A + +E + D +KLEPL+A PH  DN     E   +++D+V IGSCT G
Sbjct: 244 -EYKPLAADPDAHYANELQVDATKLEPLIAYPHRVDNVKPVSEFAGMELDQVCIGSCTNG 302

Query: 355 KTEDFMAAAKIFLASGKTVKVPT 423
           + ED   AA+I    GK V   T
Sbjct: 303 RLEDLKVAAEIL--KGKKVHKDT 323

[195][TOP]
>UniRef100_Q8TQZ3 3-isopropylmalate dehydratase large subunit 2 n=1
           Tax=Methanosarcina acetivorans RepID=LEUC2_METAC
          Length = 420

 Score =  109 bits (272), Expect = 1e-22
 Identities = 55/131 (41%), Positives = 82/131 (62%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKT-SV 177
           + V GA Y + E+ G+T+ SL++ ERMT+ NM +E GGK G++ AD  T  YL+ +    
Sbjct: 185 VGVEGARYMAAEYAGSTIRSLSIPERMTISNMAIEMGGKAGIIEADEVTEAYLQERIPGY 244

Query: 178 AYEPVY-SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
             +P + SD++A++L    +DVS LEP VA PH+ DN     E +  K+D+V++GSCT G
Sbjct: 245 KLDPYWKSDEEAKYLDIRHYDVSDLEPQVACPHNVDNVKSVSEVEGTKLDQVFMGSCTNG 304

Query: 355 KTEDFMAAAKI 387
           + ED    A I
Sbjct: 305 RFEDIKIMADI 315

[196][TOP]
>UniRef100_O28084 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Archaeoglobus
           fulgidus RepID=LEUC2_ARCFU
          Length = 416

 Score =  109 bits (272), Expect = 1e-22
 Identities = 58/139 (41%), Positives = 85/139 (61%), Gaps = 1/139 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYL-EGKTSV 177
           + V GATYK++EF G   E++T+EER+T+ NM VE G K G+  +D  T K+L E     
Sbjct: 181 LGVDGATYKALEFHGECAENMTVEERLTIANMAVECGAKAGIFESDENTRKFLAELGREG 240

Query: 178 AYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGK 357
            +  V +D+ A +  E   DVS L P+V+KPH+ DN A   E +  ++++VYIG+CT G+
Sbjct: 241 DFREVKADEDAEYEKEIYMDVSSLVPVVSKPHNVDNVAEISEVEGTEVNQVYIGTCTNGR 300

Query: 358 TEDFMAAAKIFLASGKTVK 414
             D   AA+I    G+ VK
Sbjct: 301 LSDLEVAARIL--KGRKVK 317

[197][TOP]
>UniRef100_UPI0001966774 hypothetical protein METSMIF1_00490 n=1 Tax=Methanobrevibacter
           smithii DSM 2374 RepID=UPI0001966774
          Length = 415

 Score =  108 bits (271), Expect = 1e-22
 Identities = 60/137 (43%), Positives = 82/137 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V G+TYK+ EF G TV ++++ +RM L NM +E GGK G+V  D  T  Y+E +++ A
Sbjct: 185 VGVDGSTYKACEFAGETVSNMSISDRMVLTNMAIEMGGKTGLVEPDKKTIDYVESRSNKA 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+   +D  A  L+    DVS LEP VA PH  DN     E  D +ID+V++GSCT G+ 
Sbjct: 245 YKVFKTDLDAPSLNIIDIDVSDLEPQVACPHHVDNVKAVSEV-DQEIDQVFLGSCTNGRI 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AAKI    GK V
Sbjct: 304 SDLRDAAKIL--KGKKV 318

[198][TOP]
>UniRef100_C6BSG9 3-isopropylmalate dehydratase, large subunit n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG9_DESAD
          Length = 419

 Score =  108 bits (271), Expect = 1e-22
 Identities = 55/129 (42%), Positives = 80/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V+GA YK++EF G+ VE+L++E RMT+ NM +EAGGK G+ P D+ T +Y +      
Sbjct: 186 IGVSGALYKALEFSGSVVENLSIEGRMTIANMAIEAGGKVGLFPVDAKTLEYCKAAGRTG 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
              + +D+ A +    + DV+ ++P VA PH PDN     E KD++I +  IGSCT G+ 
Sbjct: 246 DVEMRADEGASYERVVKIDVTGMKPQVACPHLPDNVKPVDEVKDMRIHQAVIGSCTNGRI 305

Query: 361 EDFMAAAKI 387
           ED   AA I
Sbjct: 306 EDLREAAAI 314

[199][TOP]
>UniRef100_B9KB94 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Thermotoga
           neapolitana DSM 4359 RepID=B9KB94_THENN
          Length = 417

 Score =  108 bits (271), Expect = 1e-22
 Identities = 59/139 (42%), Positives = 84/139 (60%), Gaps = 2/139 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V GA YK++EF G  V+ ++M+ R T+ NM +EAGGK G+ P D TT  Y E +  + 
Sbjct: 183 LGVDGANYKAIEFSGPGVKEISMDGRFTISNMAIEAGGKTGLFPVDETTIAY-EKERGIE 241

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD--VKIDRVYIGSCTGG 354
            E +Y D+ A ++ E   ++S+LEP VA P  P N     E +   +KID+V IGSCT G
Sbjct: 242 VEEMYPDEDAEYVKEVEMNLSELEPQVAYPFLPSNTKDISESEKERIKIDQVVIGSCTNG 301

Query: 355 KTEDFMAAAKIFLASGKTV 411
           + ED   AA+I    G+TV
Sbjct: 302 RIEDLRLAAQIL--KGRTV 318

[200][TOP]
>UniRef100_A7B6Z9 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC
           29149 RepID=A7B6Z9_RUMGN
          Length = 425

 Score =  108 bits (271), Expect = 1e-22
 Identities = 60/140 (42%), Positives = 79/140 (56%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +  L+M++R T+ NM +EAG KNG+ P D  T  YLE  +   
Sbjct: 185 IGVDGALYKSMEFTGDGIAHLSMDDRFTMANMAIEAGAKNGIFPVDEQTKAYLEEHSKKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE---CKDVKIDRVYIGSCTG 351
           Y+   +D+ A +      D+S++ P VA PH P N     E    + +KID+V IGSCT 
Sbjct: 245 YQIFEADEDADYEQVVTIDLSEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+ ED   AA I    G TV
Sbjct: 305 GRMEDMRKAAAIL--KGHTV 322

[201][TOP]
>UniRef100_A4FW44 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanococcus
           maripaludis C5 RepID=A4FW44_METM5
          Length = 418

 Score =  108 bits (271), Expect = 1e-22
 Identities = 54/133 (40%), Positives = 79/133 (59%), Gaps = 9/133 (6%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           GATY S+E+ G  V++L M+ERM L NM +E GGK G++ AD TTYKYLE    V+ E +
Sbjct: 184 GATYLSLEYGGNAVQNLDMDERMVLSNMAIEMGGKAGIIEADDTTYKYLE-NAGVSREEI 242

Query: 193 ---------YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
                     ++ +  +   + FD++ +E  +A PH PDN     E   +++D+V+IGSC
Sbjct: 243 LNLKKNKIKVNESEENYYKTFEFDITDMEEQIACPHHPDNVKGVSEVSGIELDQVFIGSC 302

Query: 346 TGGKTEDFMAAAK 384
           T G+  D   AAK
Sbjct: 303 TNGRLNDLRIAAK 315

[202][TOP]
>UniRef100_B5IER5 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IER5_9EURY
          Length = 418

 Score =  108 bits (271), Expect = 1e-22
 Identities = 51/137 (37%), Positives = 83/137 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ++ +GA YK++EF G T++ +T+  RM L NM  E G KNG++ AD  T  YL+ +    
Sbjct: 184 VTASGAVYKAVEFKGETIKDMTIASRMVLTNMSAEMGAKNGIIEADEKTEAYLKTRARAP 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE ++ D+ A +   Y +D S L P +A PH+ DN     + + +++++V++G+CT G+ 
Sbjct: 244 YEIMHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGIEVNQVFLGTCTNGRV 303

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AA+I    GK V
Sbjct: 304 EDLEIAARIL--KGKKV 318

[203][TOP]
>UniRef100_Q30NZ0 3-isopropylmalate dehydratase large subunit n=1 Tax=Sulfurimonas
           denitrificans DSM 1251 RepID=LEUC_SULDN
          Length = 419

 Score =  108 bits (271), Expect = 1e-22
 Identities = 60/141 (42%), Positives = 90/141 (63%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G+T+E L++++R ++CNM +EAG K+G+V  D TT  +L  K ++A
Sbjct: 185 IGVDGALYKTLEFTGSTIEHLSIDDRFSMCNMAIEAGAKSGIVAYDETTKAFLADK-NLA 243

Query: 181 YEP--VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKD-VKIDRVYIGSCT 348
            EP   YSD  A ++     DV+ L+P++A P  P N  ++ +  KD +KID+ +IGSCT
Sbjct: 244 REPRIHYSDADASYVQILNIDVASLDPVIAYPFLPSNGHSVVQAQKDNIKIDQAFIGSCT 303

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   AA+I    GK V
Sbjct: 304 NGRLSDLKVAAEIL--KGKRV 322

[204][TOP]
>UniRef100_P81291 Isopropylmalate/citramalate isomerase large subunit n=1
           Tax=Methanocaldococcus jannaschii RepID=LEUC_METJA
          Length = 424

 Score =  108 bits (271), Expect = 1e-22
 Identities = 55/139 (39%), Positives = 79/139 (56%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK---- 168
           + V GATYK+ +F G TV+ +++  RMT+ NM +E GGK G++  D  T +Y++      
Sbjct: 185 VGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKEAMKKH 244

Query: 169 -TSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   +E +  D+ A F   Y  +  K+EP+ A PH+ DN   ARE     ID+V+IGSC
Sbjct: 245 GTERPFEVIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKQAREVAGKPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED   A KI    G
Sbjct: 305 TNGRLEDLRMAIKIIEKHG 323

[205][TOP]
>UniRef100_C5CJ10 Homoaconitate hydratase family protein n=1 Tax=Kosmotoga olearia
           TBF 19.5.1 RepID=C5CJ10_KOSOT
          Length = 417

 Score =  108 bits (270), Expect = 2e-22
 Identities = 57/131 (43%), Positives = 76/131 (58%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLE--GKTS 174
           I   GA YK MEF G  +E ++ E R T+ NM +EAG K+G++  D  T  +L   G+ S
Sbjct: 181 IGADGANYKVMEFEGEVIEQISQEARFTITNMAIEAGAKSGIIAPDEKTRAFLRAYGRES 240

Query: 175 VAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
             Y  + SD  A +   Y  DVS LEP VA PH+ DN     E + +KID+V+IG+CT G
Sbjct: 241 -DYREIKSDPDAVYEKIYEIDVSNLEPAVALPHTVDNTKSISEVEGIKIDQVFIGTCTNG 299

Query: 355 KTEDFMAAAKI 387
           + ED   AA I
Sbjct: 300 RLEDLRVAASI 310

[206][TOP]
>UniRef100_A6TSE5 3-isopropylmalate dehydratase n=1 Tax=Alkaliphilus metalliredigens
           QYMF RepID=A6TSE5_ALKMQ
          Length = 425

 Score =  108 bits (270), Expect = 2e-22
 Identities = 50/124 (40%), Positives = 76/124 (61%)
 Frame = +1

Query: 16  ATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPVY 195
           A YK++E+ G TV  +++ ERM +CNM VE G K   +  D     Y++ +T   +E + 
Sbjct: 187 AVYKAIEYTGETVAEMSIAERMVICNMAVEMGAKTSYIQPDEKIIAYVKERTGKTFEILK 246

Query: 196 SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFMA 375
           +D    + + Y F+V  L+P VA PHS DN     + K+VK+D+V+IG+CTGG+ ED   
Sbjct: 247 TDDDYEYAASYTFNVEDLKPQVALPHSVDNGVDIDKIKEVKVDQVFIGTCTGGRLEDIEV 306

Query: 376 AAKI 387
           AA+I
Sbjct: 307 AARI 310

[207][TOP]
>UniRef100_C0WAT0 3-isopropylmalate dehydratase n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WAT0_9FIRM
          Length = 418

 Score =  108 bits (270), Expect = 2e-22
 Identities = 59/137 (43%), Positives = 78/137 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+S+EF G  +  L+M +R T+ NM +EAG KNG+ P D  T  Y +G+    
Sbjct: 185 IGVDGALYQSLEFTGDGIAELSMTDRFTMANMAIEAGAKNGIFPVDEKTKAYEQGRVE-D 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE V +D  A +      D++ L P+VA PH P N        D+ ID+V IGSCT G+ 
Sbjct: 244 YEIVTADSDAVYKRTVTIDLTALTPVVAFPHLPGNTKAIGTFGDIPIDQVVIGSCTNGRL 303

Query: 361 EDFMAAAKIFLASGKTV 411
           ED   AAKI    G+TV
Sbjct: 304 EDLAIAAKIL--EGRTV 318

[208][TOP]
>UniRef100_A7H0L8 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           curvus 525.92 RepID=LEUC_CAMC5
          Length = 421

 Score =  108 bits (270), Expect = 2e-22
 Identities = 56/133 (42%), Positives = 83/133 (62%), Gaps = 4/133 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G T+++L M+ R ++CNM +EAGGK+G++  D TT ++L+GK ++ 
Sbjct: 185 IGVDGARYKALEFCGETIDALDMDGRFSMCNMAIEAGGKSGIIAVDETTREFLKGK-NLR 243

Query: 181 YEP--VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVYIGSCT 348
            EP   YSD+ A +         KL+P++A P  P N    RE    D+ ID+ +IGSCT
Sbjct: 244 AEPKFFYSDEGAGYERVLEIYADKLDPVIAYPFLPSNGKSVREAVKDDIAIDQAFIGSCT 303

Query: 349 GGKTEDFMAAAKI 387
            G+  D   AA+I
Sbjct: 304 NGRLSDLRIAAEI 316

[209][TOP]
>UniRef100_Q0QLE2 2,3-dimethylmalate dehydratase large subunit n=1 Tax=Eubacterium
           barkeri RepID=Q0QLE2_EUBBA
          Length = 420

 Score =  108 bits (269), Expect = 2e-22
 Identities = 61/139 (43%), Positives = 81/139 (58%), Gaps = 1/139 (0%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  V  L+M++R T+ NM +EAGGKNG+ P D  T  Y+E   S  
Sbjct: 186 IGVDGALYRSMEFTGPGVACLSMDDRFTISNMAIEAGGKNGIFPVDDQTISYMEEHGSGD 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD-VKIDRVYIGSCTGGK 357
           Y+   +D  A +   +  D+S+L+  VA PH P+N       ++ V ID+V IGSCT G+
Sbjct: 246 YKVYAADADAVYEKTFDIDLSQLKSTVAFPHLPENTKTVDAIEEPVTIDQVVIGSCTNGR 305

Query: 358 TEDFMAAAKIFLASGKTVK 414
            ED   AA I    GK VK
Sbjct: 306 FEDLKRAADIL--RGKHVK 322

[210][TOP]
>UniRef100_C7I822 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermotoga
           naphthophila RKU-10 RepID=C7I822_9THEM
          Length = 417

 Score =  108 bits (269), Expect = 2e-22
 Identities = 58/139 (41%), Positives = 83/139 (59%), Gaps = 2/139 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V GA YK++EF G  V+ ++M+ R T+ NM +EAGGK G+ P D  T  Y E +  + 
Sbjct: 183 LGVDGANYKAIEFSGPGVKEISMDGRFTISNMAIEAGGKTGLFPVDEITIAY-ERERGIE 241

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD--VKIDRVYIGSCTGG 354
            E +Y D+ A+++ E   D+S+LEP VA P  P N     E +   +KID+  IGSCT G
Sbjct: 242 VEEMYPDEDAKYVREVEMDLSELEPQVAYPFLPSNAKDVSEAEKERIKIDQAVIGSCTNG 301

Query: 355 KTEDFMAAAKIFLASGKTV 411
           + ED   AA+I    G+TV
Sbjct: 302 RIEDLRLAAQIL--KGRTV 318

[211][TOP]
>UniRef100_C2KW91 3-isopropylmalate dehydratase n=1 Tax=Oribacterium sinus F0268
           RepID=C2KW91_9FIRM
          Length = 421

 Score =  108 bits (269), Expect = 2e-22
 Identities = 52/129 (40%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+S+EF G  V SL+M++R  +CNM +EAGGKNG+ P D  T +Y++  ++  
Sbjct: 186 IGVDGALYESIEFTGEGVASLSMDDRFAICNMAIEAGGKNGIFPVDEKTLEYIKAHSNKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y    +D+ A +      D+S L+  VA PH P+N       + + ID+  IGSCT G+ 
Sbjct: 246 YHIYEADEDAEYDRVIEIDLSSLKSTVAFPHLPENTHEIGSFEKISIDQAVIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
            D   AA+I
Sbjct: 306 SDIKVAAEI 314

[212][TOP]
>UniRef100_B6BGP4 3-isopropylmalate dehydratase large subunit n=1
           Tax=Campylobacterales bacterium GD 1 RepID=B6BGP4_9PROT
          Length = 419

 Score =  108 bits (269), Expect = 2e-22
 Identities = 60/141 (42%), Positives = 89/141 (63%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G+T+E L M++R ++CNM +EAG K+G+V  D  T ++L  K  +A
Sbjct: 185 IGVDGALYKTLEFTGSTIEHLNMDDRFSMCNMAIEAGAKSGIVAYDDITKEFLADK-DLA 243

Query: 181 YEPV--YSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKD-VKIDRVYIGSCT 348
            EP   YSD  A ++     +V++LEP++A P  P N  ++ +  KD +KID+ +IGSCT
Sbjct: 244 REPKIHYSDADAAYVQVLDINVAELEPVIAYPFLPSNGHSITQAVKDKIKIDQAFIGSCT 303

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   AA+I    GK V
Sbjct: 304 NGRLGDLKTAAEIL--DGKKV 322

[213][TOP]
>UniRef100_A9AAG0 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C6 RepID=A9AAG0_METM6
          Length = 424

 Score =  108 bits (269), Expect = 2e-22
 Identities = 52/139 (37%), Positives = 80/139 (57%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEG----- 165
           +   GATYK+ +F G TV+++T+  RM++ NM +E GGK G++  D  T  Y++      
Sbjct: 185 VGADGATYKAAQFAGNTVDNMTIASRMSMSNMAIEMGGKAGLIAPDDKTINYVKNAMETN 244

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T+  +E +  D+ A F  ++  +V  LEP++A PH+ DN    RE     ID+V+IGSC
Sbjct: 245 NTAKPFEFILGDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKAVREVAGTPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED  AA  +    G
Sbjct: 305 TNGRIEDLRAALNVIEKHG 323

[214][TOP]
>UniRef100_A0B7A3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosaeta
           thermophila PT RepID=A0B7A3_METTP
          Length = 382

 Score =  108 bits (269), Expect = 2e-22
 Identities = 57/137 (41%), Positives = 81/137 (59%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           GA Y S+EFVG  VE L++  RMTLCNM VE G K  +VP D +   YL  +    Y  +
Sbjct: 157 GANYMSVEFVGGAVERLSISGRMTLCNMGVEMGAKAAIVPPDESVDAYLARRARRPYTHI 216

Query: 193 YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFM 372
           +SD    +  E  +DVS + P++A P+  DN    R+   +++D+V+IG+CT G+ ED  
Sbjct: 217 HSD-PGSYYREIEYDVSDIPPMIAAPYRVDNVHPVRDLAGIEVDQVFIGTCTNGRLEDLE 275

Query: 373 AAAKIFLASGKTVKVPT 423
            AA+I    GK VK+ T
Sbjct: 276 MAARI--VKGKRVKIRT 290

[215][TOP]
>UniRef100_Q9WZ24 3-isopropylmalate dehydratase large subunit 2 n=2 Tax=Thermotoga
           RepID=LEUC2_THEMA
          Length = 417

 Score =  108 bits (269), Expect = 2e-22
 Identities = 58/139 (41%), Positives = 83/139 (59%), Gaps = 2/139 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V GA YK++EF G  V+ ++M+ R T+ NM +EAGGK G+ P D  T  Y E +  + 
Sbjct: 183 LGVDGANYKAIEFSGPGVKEISMDGRFTISNMAIEAGGKTGLFPVDEITIAY-ERERGIE 241

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD--VKIDRVYIGSCTGG 354
            E +Y D+ A+++ E   D+S+LEP VA P  P N     E +   +KID+  IGSCT G
Sbjct: 242 VEEMYPDEDAKYVREVEMDLSELEPQVAYPFLPSNAKDVSEAEKERIKIDQAVIGSCTNG 301

Query: 355 KTEDFMAAAKIFLASGKTV 411
           + ED   AA+I    G+TV
Sbjct: 302 RIEDLRLAAQIL--KGRTV 318

[216][TOP]
>UniRef100_C0GFG9 Homoaconitate hydratase family protein n=1 Tax=Dethiobacter
           alkaliphilus AHT 1 RepID=C0GFG9_9FIRM
          Length = 428

 Score =  107 bits (268), Expect = 3e-22
 Identities = 60/139 (43%), Positives = 77/139 (55%), Gaps = 10/139 (7%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYL------- 159
           ++V GAT K +EF G  V+ ++ME RMTLCNM +EAGG  GV   D TT +YL       
Sbjct: 184 LTVNGATNKVIEFSGPVVDEMSMESRMTLCNMAIEAGGTCGVCYPDMTTVEYLWEFIKDE 243

Query: 160 ---EGKTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRV 330
              + +    Y    SD  A +   Y +DVS+LEP+V     PD     RE    KID++
Sbjct: 244 FNSKEEALKEYSKWMSDDDATYEKVYEYDVSELEPMVTFGFKPDQVKPVREMAGTKIDQI 303

Query: 331 YIGSCTGGKTEDFMAAAKI 387
           YIGSCT G+ ED   AA I
Sbjct: 304 YIGSCTNGRIEDLRIAASI 322

[217][TOP]
>UniRef100_A5IJM1 3-isopropylmalate dehydratase, large subunit n=2 Tax=Thermotogaceae
           RepID=A5IJM1_THEP1
          Length = 417

 Score =  107 bits (268), Expect = 3e-22
 Identities = 58/139 (41%), Positives = 83/139 (59%), Gaps = 2/139 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V GA YK++EF G  V+ ++M+ R T+ NM +EAGGK G+ P D  T  Y E +  + 
Sbjct: 183 LGVDGANYKAIEFSGPGVKEISMDGRFTVSNMAIEAGGKTGLFPVDEITIAY-ERERGIE 241

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKD--VKIDRVYIGSCTGG 354
            E +Y D+ A+++ E   D+S+LEP VA P  P N     E +   +KID+  IGSCT G
Sbjct: 242 VEEMYPDEDAKYVREVEMDLSELEPQVAYPFLPSNAKDVSEAEKERIKIDQAVIGSCTNG 301

Query: 355 KTEDFMAAAKIFLASGKTV 411
           + ED   AA+I    G+TV
Sbjct: 302 RIEDLRLAAQIL--KGRTV 318

[218][TOP]
>UniRef100_Q46AJ7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosarcina
           barkeri str. Fusaro RepID=Q46AJ7_METBF
          Length = 431

 Score =  107 bits (268), Expect = 3e-22
 Identities = 54/131 (41%), Positives = 81/131 (61%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTS-V 177
           + V GA Y + EF G+T+ SL++ ERMT+ NM +E GGK G++ AD  T  YL+ +    
Sbjct: 196 VGVEGARYMAAEFGGSTIHSLSIPERMTMSNMAIEMGGKAGIIEADEVTANYLKERIMYY 255

Query: 178 AYEPVY-SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
            ++P + SD+ A+++    +DVS LEP VA PH  DN     E +  K+D++++GSCT G
Sbjct: 256 EFDPYWKSDEDAKYVGIRHYDVSDLEPQVACPHHVDNVKPVTEVEGTKLDQIFVGSCTNG 315

Query: 355 KTEDFMAAAKI 387
           + ED    A I
Sbjct: 316 RFEDIKIMADI 326

[219][TOP]
>UniRef100_C6PJB4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacter italicus Ab9 RepID=C6PJB4_9THEO
          Length = 418

 Score =  107 bits (267), Expect = 4e-22
 Identities = 57/137 (41%), Positives = 79/137 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++L+M++R T+ NM +EAG KNG+   D  T  Y++G+    
Sbjct: 185 IGVDGALYKSMEFTGN-IKTLSMDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKRE 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+    D+ A +   Y  ++ ++ P VA PH P+N     E   VKID+V IGSCT G+ 
Sbjct: 244 YKVFERDEDAEYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKVKIDQVVIGSCTNGRL 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D   A KI    GK V
Sbjct: 304 SDMEIAYKIL--KGKKV 318

[220][TOP]
>UniRef100_C3XJX6 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           winghamensis ATCC BAA-430 RepID=C3XJX6_9HELI
          Length = 422

 Score =  107 bits (267), Expect = 4e-22
 Identities = 57/141 (40%), Positives = 89/141 (63%), Gaps = 4/141 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+++EF G  +  L+M++R +LCNM +EAG KNG++  DS T ++L  ++++ 
Sbjct: 185 IGVDGALYQALEFCGEGISYLSMDDRFSLCNMAIEAGAKNGIIAPDSITREFLASRSNLR 244

Query: 181 YEP--VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDN-RALARECKD-VKIDRVYIGSCT 348
            +P   +SD  A +      D+SKLEP+VA P  P N + +++  KD +KID+ +IGSCT
Sbjct: 245 AKPKEFFSDIDANYTRTLTIDISKLEPVVAYPFLPSNGKNISQAVKDNLKIDQAFIGSCT 304

Query: 349 GGKTEDFMAAAKIFLASGKTV 411
            G+  D   A++I    GK V
Sbjct: 305 NGRLSDLKIASEIL--KGKKV 323

[221][TOP]
>UniRef100_C2A003 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurospirillum deleyianum DSM 6946
           RepID=C2A003_SULDE
          Length = 421

 Score =  107 bits (267), Expect = 4e-22
 Identities = 56/133 (42%), Positives = 81/133 (60%), Gaps = 4/133 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V GA Y+++EF G T+  L+M++R +LCNM +EAG K+G+V  D  T  +L  K ++A
Sbjct: 185 LGVDGALYRTLEFTGDTIGHLSMDDRFSLCNMAIEAGAKSGIVAVDEITKAFLSDK-NLA 243

Query: 181 YEP--VYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALAREC--KDVKIDRVYIGSCT 348
            EP   YSD  A ++     DV+ L+P++A P  P N     E    D+ ID+V+IGSCT
Sbjct: 244 REPKFFYSDDDATYVQVLHIDVANLDPVIAYPFLPSNGKSINEAVKDDLAIDQVFIGSCT 303

Query: 349 GGKTEDFMAAAKI 387
            G+ ED   AA I
Sbjct: 304 NGRLEDLRIAASI 316

[222][TOP]
>UniRef100_Q12UW0 Homoaconitase large subunit n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=Q12UW0_METBU
          Length = 428

 Score =  107 bits (267), Expect = 4e-22
 Identities = 52/131 (39%), Positives = 81/131 (61%), Gaps = 2/131 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK-TSV 177
           +   GA Y + E+ G+ +E LT+ ERMT+ NM +E GGK G++ AD TT  YL+ +    
Sbjct: 193 VGAEGARYMAAEYAGSAIEGLTISERMTISNMAIEMGGKAGIIEADKTTEAYLKERIPDY 252

Query: 178 AYEPVY-SDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGG 354
            ++P + SD+ A +   + ++VS LEP VA PH+ DN     E +  K+D+V++GSCT G
Sbjct: 253 EFDPYWKSDEDAEYAEFHDYNVSDLEPQVACPHNVDNVKPVSEVEGTKVDQVFVGSCTNG 312

Query: 355 KTEDFMAAAKI 387
           + ED    A++
Sbjct: 313 RFEDIKIVAEM 323

[223][TOP]
>UniRef100_A6VH65 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C7 RepID=A6VH65_METM7
          Length = 418

 Score =  107 bits (267), Expect = 4e-22
 Identities = 58/147 (39%), Positives = 82/147 (55%), Gaps = 9/147 (6%)
 Frame = +1

Query: 10  AGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEP 189
           +GATY S+E+ G  V++L M ERM L NM +E GGK G++ AD TTYKYLE    V+ E 
Sbjct: 183 SGATYMSLEYGGNAVQNLEMNERMVLSNMAIEMGGKAGIIEADDTTYKYLE-NAGVSREE 241

Query: 190 V---------YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGS 342
           +          ++ +  +     FD++ +E  +A PH+PDN     E    ++D+V+IGS
Sbjct: 242 ILNLKKNKITVNESEENYYKTIEFDITDMEEQIACPHNPDNVKGVSEVSGTELDQVFIGS 301

Query: 343 CTGGKTEDFMAAAKIFLASGKTVKVPT 423
           CT G+  D   AAK     GK V   T
Sbjct: 302 CTNGRLNDLRIAAKYL--KGKKVNENT 326

[224][TOP]
>UniRef100_B0NXK1 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1
           RepID=B0NXK1_9CLOT
          Length = 423

 Score =  107 bits (266), Expect = 5e-22
 Identities = 54/137 (39%), Positives = 78/137 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           +   G  YK MEF G    +L ++ER+ LCN+ VEAG K G+V  D    +Y+E +   A
Sbjct: 190 VGANGCNYKIMEFAGEGAHNLDIDERLVLCNLAVEAGAKTGIVEPDEKVVEYVESRGRKA 249

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
                SD  A F   Y  ++ +++P+VA+PH  D+   A+E KDVKID  ++GSC  G+ 
Sbjct: 250 ENLFKSDDDAVFEKVYDINLDEIKPVVARPHQIDDVVDAKEVKDVKIDEAFLGSCNNGRI 309

Query: 361 EDFMAAAKIFLASGKTV 411
           E+   AA+I    GK V
Sbjct: 310 EELRVAAEIL--KGKKV 324

[225][TOP]
>UniRef100_B0MIT8 Putative uncharacterized protein n=1 Tax=Anaerostipes caccae DSM
           14662 RepID=B0MIT8_9FIRM
          Length = 413

 Score =  107 bits (266), Expect = 5e-22
 Identities = 53/137 (38%), Positives = 77/137 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           +   G  YK MEF G    +L++ ER+ LCN+ VEAG K G+V  D    +Y+E +   A
Sbjct: 183 VGANGCNYKIMEFAGEGAHNLSINERLVLCNLAVEAGAKTGIVEPDEKVVEYVESRGRKA 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
                SD+ ARF   Y  ++ ++EP+VA+PH  D+     E  DVKID  ++GSC  G+ 
Sbjct: 243 ENLFVSDEDARFEKVYHINLDEIEPVVARPHLIDDVVPVEEAGDVKIDEAFLGSCNNGRI 302

Query: 361 EDFMAAAKIFLASGKTV 411
           ++   AA+I    GK V
Sbjct: 303 DELRLAAEIL--KGKKV 317

[226][TOP]
>UniRef100_A5ZNE1 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC
           29174 RepID=A5ZNE1_9FIRM
          Length = 416

 Score =  107 bits (266), Expect = 5e-22
 Identities = 54/137 (39%), Positives = 78/137 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           +   G  Y+ MEF G   ++L++ +RMTLCNM VEAG K G+  AD    +YL+      
Sbjct: 183 VGANGCNYQVMEFTGEGAKTLSISDRMTLCNMAVEAGAKTGIFEADEKAMEYLKEHGREP 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
               +SD  A+++ EY FD+SK+ P+VAKP   DN   A E   ++I+  ++GSC  G+ 
Sbjct: 243 KAVFHSDPDAKYVREYTFDLSKVRPVVAKPDFVDNVVPAEEACGIEINEAFLGSCNNGRI 302

Query: 361 EDFMAAAKIFLASGKTV 411
           ED    A+I    GK V
Sbjct: 303 EDLRVGAEII--KGKKV 317

[227][TOP]
>UniRef100_C7P908 3-isopropylmalate dehydratase n=1 Tax=Methanocaldococcus fervens
           AG86 RepID=C7P908_METFA
          Length = 420

 Score =  107 bits (266), Expect = 5e-22
 Identities = 55/143 (38%), Positives = 82/143 (57%), Gaps = 9/143 (6%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           GATY ++E+ G  V+ + M+ R+TLCNM +E GGK GV+ AD  TY YL+ +  ++ E +
Sbjct: 183 GATYMAIEYGGEVVKRMNMDGRLTLCNMAIEMGGKTGVIEADEITYNYLKNERGLSDEKI 242

Query: 193 ---------YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
                     +  +A +  E   D++ +E  VA PH PDN     E +  +I++V+IGSC
Sbjct: 243 AELKKERITVNKDEANYYREIEIDITDMEEQVAVPHHPDNVKPVSEVEGTEINQVFIGSC 302

Query: 346 TGGKTEDFMAAAKIFLASGKTVK 414
           T G+  D   AAK +L  GK  K
Sbjct: 303 TNGRLSDLREAAK-YLKGGKVHK 324

[228][TOP]
>UniRef100_C8X2U8 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfohalobium retbaense DSM 5692
           RepID=C8X2U8_9DELT
          Length = 419

 Score =  106 bits (265), Expect = 7e-22
 Identities = 58/137 (42%), Positives = 79/137 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YK++EF G TV  L +E R+T+ NM +EAGGK G+ PAD TT  YL+      
Sbjct: 186 IGVDGALYKALEFGGGTVRDLDLEARLTIANMAIEAGGKVGLFPADQTTLDYLQAHGRSG 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
              + +D+ A +      D + L+P VA PH P+N    R+  D+ +D+V IGSCT G+ 
Sbjct: 246 DTFLEADEGAGYERRVAIDAASLQPQVACPHLPENVHPVRDVGDIPLDQVVIGSCTNGRI 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA+  L  GK V
Sbjct: 306 SDLREAAE--LLKGKKV 320

[229][TOP]
>UniRef100_C4EWE6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermanaerovibrio acidaminovorans DSM 6589
           RepID=C4EWE6_9BACT
          Length = 417

 Score =  106 bits (265), Expect = 7e-22
 Identities = 55/129 (42%), Positives = 77/129 (59%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           + V GA Y+++EF G  V SL+M+ RMT+ NM +E G K  +   D  T  Y+  +   +
Sbjct: 183 LGVDGARYRALEFHGDGVRSLSMDGRMTMANMGIECGAKAALFVPDEATLAYVAPRARRS 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +EPVY D  A +  E    +  L PLVA P+ P N   ARE +DV+I +V+IGSCT G+ 
Sbjct: 243 FEPVYPDPGAAYERELTVRLDSLPPLVACPNLPSNVRPARELRDVEIHQVFIGSCTNGRI 302

Query: 361 EDFMAAAKI 387
           ED   AAK+
Sbjct: 303 EDLRQAAKV 311

[230][TOP]
>UniRef100_C0UYG1 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermobaculum
           terrenum ATCC BAA-798 RepID=C0UYG1_9BACT
          Length = 380

 Score =  106 bits (265), Expect = 7e-22
 Identities = 55/129 (42%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GATY ++E+ G  V  +++ ERMTL NM VE GGK G+V  D T  +YL G+    
Sbjct: 180 IGVDGATYMAVEYGGPAVRRMSISERMTLANMAVEMGGKTGLVEPDDTVDEYLRGRARDP 239

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE + + +   +      D S +EP+VA P  P++ A A E + VKID+V+IG+CT G+ 
Sbjct: 240 YERI-TPRDPVYSRVVEIDASSIEPMVAVPPDPEHLAPAAEMRKVKIDQVFIGTCTNGRL 298

Query: 361 EDFMAAAKI 387
           +D   AA+I
Sbjct: 299 DDIEIAARI 307

[231][TOP]
>UniRef100_A7VNU8 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753
           RepID=A7VNU8_9CLOT
          Length = 428

 Score =  106 bits (265), Expect = 7e-22
 Identities = 57/137 (41%), Positives = 76/137 (55%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+SMEF G  ++ L++++R+ + NM +EAG KNG+ P D  T  Y  G+    
Sbjct: 186 IGVDGALYQSMEFAGDGLQYLSIDDRLCIANMAIEAGAKNGIFPVDDVTRAYCNGRFQGT 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
                +D+ A +  EY  D+S L P VA PH P+N         VKID+V IGSCT G+ 
Sbjct: 246 PVEYAADEDAVYEKEYVIDLSALRPTVAFPHLPENTRTIDNVGQVKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKIFLASGKTV 411
            D   AA   L  GK V
Sbjct: 306 SDLRIAAN--LLKGKKV 320

[232][TOP]
>UniRef100_A0ZF76 3-isopropylmalate dehydratase, LeuC subunit n=1 Tax=Nodularia
           spumigena CCY9414 RepID=A0ZF76_NODSP
          Length = 574

 Score =  106 bits (265), Expect = 7e-22
 Identities = 50/129 (38%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I  AGAT K MEF G+ +E +  +ER+TL NM +E G   G++  D TT  Y+  ++   
Sbjct: 342 IGCAGATSKVMEFRGSILEQMPFDERLTLANMAIECGAICGLIVPDETTRNYVRSRSDQE 401

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +E + +D  A +   Y+FD+S LEP +A+P  PD      + ++  I + +IGSCTGGK 
Sbjct: 402 FEELIADPDAEYEKVYKFDISNLEPQIARPPKPDQVVPISQIEETPITKAFIGSCTGGKL 461

Query: 361 EDFMAAAKI 387
            D   AA++
Sbjct: 462 YDLAQAAEV 470

[233][TOP]
>UniRef100_A6UPF6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           vannielii SB RepID=A6UPF6_METVS
          Length = 424

 Score =  106 bits (265), Expect = 7e-22
 Identities = 51/139 (36%), Positives = 81/139 (58%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLE-----G 165
           +   GATYK+ +F G TV+ +T+  RMT+ NM +E GGK G++  D  T +Y++      
Sbjct: 185 VGADGATYKAAQFAGETVKEMTIASRMTMSNMAIEMGGKAGLIEPDRKTVEYVKTAMEKN 244

Query: 166 KTSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T+  ++ +  D+ A +  ++  +V+ LEP++A PH+ DN    RE     ID+V+IGSC
Sbjct: 245 NTARPFDIIIGDKNAEYEEKFEIEVNDLEPVMACPHNVDNVKTVREVSGTPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED  AA  +    G
Sbjct: 305 TNGRIEDLRAALNVIEKHG 323

[234][TOP]
>UniRef100_B8DM92 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=LEUC_DESVM
          Length = 418

 Score =  106 bits (265), Expect = 7e-22
 Identities = 56/129 (43%), Positives = 79/129 (61%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA Y+++EF G  +E+L++E RMT+ NM +EAGGK G+  AD+ T  Y   +    
Sbjct: 186 IGVDGALYRALEFDGAAIEALSVEGRMTIANMAIEAGGKAGLFAADAKTLAYTAARGRKD 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
             P+ +D  A +  E  FDVS +EPLVA PH P+N     E + V +D+V IGSCT G+ 
Sbjct: 246 -APLSADPGATYERELTFDVSGMEPLVACPHLPENVKPVGEVRGVTLDQVVIGSCTNGRI 304

Query: 361 EDFMAAAKI 387
            D   AA++
Sbjct: 305 SDMREAAEV 313

[235][TOP]
>UniRef100_UPI0001979722 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI0001979722
          Length = 420

 Score =  106 bits (264), Expect = 9e-22
 Identities = 50/129 (38%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++LT+++R+ + NM +EAG KNG+   D  T +Y +G+TS  
Sbjct: 186 IGVDGALYKSMEFSGEGLKNLTIDDRLCIANMAIEAGAKNGIFEVDDITIEYAKGRTSKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +    +D+ A +   +  ++  ++  VA PH P+N     +  ++KID+V IGSCT G+ 
Sbjct: 246 FRIYKADEDAEYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEIKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 306 SDMEVAANI 314

[236][TOP]
>UniRef100_UPI000196B289 hypothetical protein CATMIT_00953 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196B289
          Length = 425

 Score =  106 bits (264), Expect = 9e-22
 Identities = 59/140 (42%), Positives = 77/140 (55%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  V+ L+M +R T+CNM +EAG KNG+ P D    +YL+      
Sbjct: 185 IGVDGALYKSMEFTGEGVKELSMADRFTICNMAIEAGAKNGIFPVDEAAIEYLDKHAKRD 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECK---DVKIDRVYIGSCTG 351
           Y+   +D+ A +      D+S + P VA PH P N     E +    + ID+V IGSCT 
Sbjct: 245 YKIYEADKDAEYEEIVDVDLSAIRPTVAFPHLPGNAKTVDEIEAMDKIYIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+ ED   AA I    GK V
Sbjct: 305 GRMEDLRKAAAIL--KGKKV 322

[237][TOP]
>UniRef100_Q3AD33 3-isopropylmalate dehydratase, large subunit family protein n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AD33_CARHZ
          Length = 417

 Score =  106 bits (264), Expect = 9e-22
 Identities = 49/129 (37%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           ++  GATY + E+ G  +  L+M+ R T+ NM +E G K G++ AD  T+ +++      
Sbjct: 183 VTADGATYMAAEYTGEAISDLSMDGRFTIANMAIEMGAKAGLMEADEKTFAFVKEHGGKD 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           + PV++D  A +     +DVS+LEP+VAKPH+ DN A   E     I +  +G+CT G+ 
Sbjct: 243 FTPVFADPDAVYAKVLEYDVSELEPMVAKPHTVDNTARVTEVAGTPIHQAVLGTCTNGRL 302

Query: 361 EDFMAAAKI 387
           ED   AAKI
Sbjct: 303 EDLRIAAKI 311

[238][TOP]
>UniRef100_B2J8P2 Homoaconitate hydratase family protein n=1 Tax=Nostoc punctiforme
           PCC 73102 RepID=B2J8P2_NOSP7
          Length = 569

 Score =  106 bits (264), Expect = 9e-22
 Identities = 52/129 (40%), Positives = 76/129 (58%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I  AGAT K MEF G+ +  L  +ER+TL NM VE G   G++  D  T +YL+ + S  
Sbjct: 337 IGCAGATSKVMEFRGSILAQLPFDERLTLANMAVECGAICGLIVPDEVTREYLKNRVSEE 396

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           ++ +  D  A +   Y+FD+S LEP VA+P  PD      + +++ I + +IGSCTGGK 
Sbjct: 397 FQEIIGDADAEYERVYQFDLSSLEPQVARPPKPDRVVAISQLENIPITKAFIGSCTGGKL 456

Query: 361 EDFMAAAKI 387
            D   AA++
Sbjct: 457 YDLAQAAEV 465

[239][TOP]
>UniRef100_C3XG48 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XG48_9HELI
          Length = 420

 Score =  106 bits (264), Expect = 9e-22
 Identities = 50/129 (38%), Positives = 78/129 (60%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++LT+++R+ + NM +EAG KNG+   D  T +Y +G+TS  
Sbjct: 186 IGVDGALYKSMEFSGEGLKNLTIDDRLCIANMAIEAGAKNGIFEVDDITIEYAKGRTSKE 245

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           +    +D+ A +   +  ++  ++  VA PH P+N     +  ++KID+V IGSCT G+ 
Sbjct: 246 FRIYKADEDAEYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEIKIDQVVIGSCTNGRL 305

Query: 361 EDFMAAAKI 387
            D   AA I
Sbjct: 306 SDMEVAANI 314

[240][TOP]
>UniRef100_B5CQV8 Putative uncharacterized protein n=1 Tax=Ruminococcus lactaris ATCC
           29176 RepID=B5CQV8_9FIRM
          Length = 424

 Score =  106 bits (264), Expect = 9e-22
 Identities = 60/140 (42%), Positives = 76/140 (54%), Gaps = 3/140 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +  L+M++R T+ NM +EAG KNG+ P D  T  YL       
Sbjct: 185 IGVDGALYKSMEFTGDGIACLSMDDRFTMANMAIEAGAKNGIFPVDEKTKAYLAEHCKKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE---CKDVKIDRVYIGSCTG 351
           Y    +D+ A +      D+SK+ P VA PH P N     E    + +KID+V IGSCT 
Sbjct: 245 YTVYEADEDAVYDEVIEIDLSKVRPTVAFPHLPGNAKTIDEVEAMEPIKIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKIFLASGKTV 411
           G+ ED   AA I    G TV
Sbjct: 305 GRMEDLRKAAAIL--KGHTV 322

[241][TOP]
>UniRef100_C9RGT8 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           vulcanius M7 RepID=C9RGT8_9EURY
          Length = 422

 Score =  106 bits (264), Expect = 9e-22
 Identities = 53/139 (38%), Positives = 80/139 (57%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK---- 168
           + V GATYK+ +F G TV+++++  RMT+ NM +E GGK G++  D  T +Y++      
Sbjct: 183 VGVDGATYKACQFGGETVKNMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKEAMKKH 242

Query: 169 -TSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   +E +  D+ A F   Y  +  K+EP+ A PH+ DN   ARE     ID+V+IGSC
Sbjct: 243 GTERPFEIIKGDEDAEFEEVYEIEADKIEPVFACPHNVDNVKQAREVAGRPIDQVFIGSC 302

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED   A ++    G
Sbjct: 303 TNGRVEDLRMAIEVIEKHG 321

[242][TOP]
>UniRef100_B5IEF0 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IEF0_9EURY
          Length = 418

 Score =  106 bits (264), Expect = 9e-22
 Identities = 47/129 (36%), Positives = 80/129 (62%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I+ +GA YK++EF G T+ ++++  R+ L NM  E G KNG++ AD  T  YL+ +    
Sbjct: 184 ITASGAVYKAVEFKGETIRNMSIASRIVLTNMSAEMGAKNGIIEADEKTEAYLKTRARAP 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           YE ++ D+ A +   Y +D S L P +A PH+ DN     + + +++++V++G+CT G+ 
Sbjct: 244 YEIMHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGIEVNQVFLGTCTNGRV 303

Query: 361 EDFMAAAKI 387
           ED   AA+I
Sbjct: 304 EDLEVAARI 312

[243][TOP]
>UniRef100_B6FST2 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM
           1787 RepID=B6FST2_9CLOT
          Length = 438

 Score =  105 bits (263), Expect = 1e-21
 Identities = 54/132 (40%), Positives = 76/132 (57%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  + +L+M++R T+ NM +EAG KNG+   D     Y++  +   
Sbjct: 199 IGVDGALYKSMEFVGDGIANLSMDDRFTMANMAIEAGAKNGIFIVDEKAEAYMKEHSEKE 258

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRAL---ARECKDVKIDRVYIGSCTG 351
           Y+   +D+ A +      D+SK+ P VA PH P N        E + +KID+V IGSCT 
Sbjct: 259 YKVYTADEDAEYDEVVEIDLSKVRPTVAFPHLPGNAKTIDEVEEMEPIKIDQVVIGSCTN 318

Query: 352 GKTEDFMAAAKI 387
           G+ ED   AA +
Sbjct: 319 GRMEDMRRAAAV 330

[244][TOP]
>UniRef100_C5U763 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           infernus ME RepID=C5U763_9EURY
          Length = 424

 Score =  105 bits (263), Expect = 1e-21
 Identities = 52/139 (37%), Positives = 78/139 (56%), Gaps = 5/139 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK---- 168
           + V GATYK+ +F G TV+++++  RMT+ NM +E GGK G++  D  T  Y++      
Sbjct: 185 VGVDGATYKACQFGGETVKNMSIASRMTMTNMAIEMGGKTGIIEPDEKTINYVKEAMEKH 244

Query: 169 -TSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   ++P+  D+ A F   Y  +  K+EP+ A PH+ DN    RE     ID+V+IGSC
Sbjct: 245 GTLREFKPIKGDEDAEFSEVYEIEADKIEPVFACPHNVDNVKQCREVAGKPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKIFLASG 402
           T G+ ED   A  +    G
Sbjct: 305 TNGRLEDLRMAINVIEKHG 323

[245][TOP]
>UniRef100_B0K0Y2 3-isopropylmalate dehydratase large subunit n=4
           Tax=Thermoanaerobacter RepID=LEUC_THEPX
          Length = 418

 Score =  105 bits (263), Expect = 1e-21
 Identities = 56/137 (40%), Positives = 79/137 (57%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++L++++R T+ NM +EAG KNG+   D  T  Y++G+    
Sbjct: 185 IGVDGALYKSMEFTGN-IKALSIDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKRE 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+    D+ A +   Y  ++ ++ P VA PH P+N     E   VKID+V IGSCT G+ 
Sbjct: 244 YKVFERDEDAEYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKVKIDQVVIGSCTNGRL 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D   A KI    GK V
Sbjct: 304 SDMEIAYKIL--KGKKV 318

[246][TOP]
>UniRef100_A9A9I4 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C6 RepID=A9A9I4_METM6
          Length = 418

 Score =  105 bits (262), Expect = 2e-21
 Identities = 56/146 (38%), Positives = 80/146 (54%), Gaps = 9/146 (6%)
 Frame = +1

Query: 13  GATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVAYEPV 192
           GATY S+E+ G  V++L M+ERM L NM +E GGK G++ AD TTY+YLE    V+ E +
Sbjct: 184 GATYMSLEYAGNAVQNLDMDERMVLSNMAIEMGGKAGIIEADDTTYRYLE-NAGVSREEI 242

Query: 193 ---------YSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
                     ++ +  +     FD+  +E  +A PH PDN     E    ++D+V+IGSC
Sbjct: 243 LNLKKNKITVNESEENYYKTVEFDIIDMEEQIACPHHPDNVKGVSEVSGTELDQVFIGSC 302

Query: 346 TGGKTEDFMAAAKIFLASGKTVKVPT 423
           T G+  D   AA+     GK V   T
Sbjct: 303 TNGRLNDLRTAARYL--KGKKVNEST 326

[247][TOP]
>UniRef100_C7P7J9 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           fervens AG86 RepID=C7P7J9_METFA
          Length = 424

 Score =  105 bits (262), Expect = 2e-21
 Identities = 53/134 (39%), Positives = 78/134 (58%), Gaps = 5/134 (3%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGK---- 168
           + V GATYK+ +F G TV+ +++  RMT+ NM +E GGK G++  D  T +Y++      
Sbjct: 185 VGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTVQYVKEAMKKH 244

Query: 169 -TSVAYEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSC 345
            T   +E +  D+ A F   Y  +  K+EP+ A PH+ DN   ARE     ID+V+IGSC
Sbjct: 245 GTERPFEIIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKPAREVAGRPIDQVFIGSC 304

Query: 346 TGGKTEDFMAAAKI 387
           T G+ ED   A +I
Sbjct: 305 TNGRFEDLKMAIEI 318

[248][TOP]
>UniRef100_C0F065 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM
           3353 RepID=C0F065_9FIRM
          Length = 417

 Score =  105 bits (261), Expect = 2e-21
 Identities = 56/139 (40%), Positives = 78/139 (56%), Gaps = 2/139 (1%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I   GA YK MEF G    +L++++RM LCN+ VEAG K G+V  D    +Y +     A
Sbjct: 183 IGANGANYKIMEFAGDGAHNLSVDDRMVLCNLTVEAGAKAGIVEPDEKVVEYCKAHGREA 242

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVK--IDRVYIGSCTGG 354
                SD+ A F   Y +D+SK+EP+V +P   DN AL ++ K  K  ID  ++GSC  G
Sbjct: 243 VHMFKSDEDAHFCEVYDYDLSKIEPVVVRPDFVDNFALLKDVKKEKIAIDEAFLGSCNNG 302

Query: 355 KTEDFMAAAKIFLASGKTV 411
           + +D   AA+I    GK V
Sbjct: 303 RIDDLRVAAEI--VKGKQV 319

[249][TOP]
>UniRef100_B0KAH5 3-isopropylmalate dehydratase large subunit n=3
           Tax=Thermoanaerobacter RepID=LEUC_THEP3
          Length = 417

 Score =  105 bits (261), Expect = 2e-21
 Identities = 57/137 (41%), Positives = 77/137 (56%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEF G  +++L+M++R T+ NM +EAG KNG+   D  T  Y++G+    
Sbjct: 185 IGVDGALYKSMEFTGN-IKALSMDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKRE 243

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKT 360
           Y+    D  A +   Y   + ++ P VA PH P+N     E   VKID+V IGSCT G+ 
Sbjct: 244 YKVFERDVDAEYSEVYEISLDEIRPQVAFPHLPENTRNIDEVGKVKIDQVVIGSCTNGRI 303

Query: 361 EDFMAAAKIFLASGKTV 411
            D   A KI    GK V
Sbjct: 304 SDMEIAYKIL--KGKKV 318

[250][TOP]
>UniRef100_B0NJ74 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC
           35704 RepID=B0NJ74_EUBSP
          Length = 424

 Score =  104 bits (260), Expect = 3e-21
 Identities = 55/132 (41%), Positives = 77/132 (58%), Gaps = 3/132 (2%)
 Frame = +1

Query: 1   ISVAGATYKSMEFVGTTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTYKYLEGKTSVA 180
           I V GA YKSMEFVG  + SLTM++R T+ NM +EAG KNG+   D    +Y++  +   
Sbjct: 185 IGVDGALYKSMEFVGDGIASLTMDDRFTMANMAIEAGAKNGIFLVDEKAEEYMKEHSDKE 244

Query: 181 YEPVYSDQQARFLSEYRFDVSKLEPLVAKPHSPDNRALARE---CKDVKIDRVYIGSCTG 351
           Y+   +D  A + +    D++K+ P VA PH P N     E    + +KID+V IGSCT 
Sbjct: 245 YKIYEADADADYDAVVEVDLAKVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTN 304

Query: 352 GKTEDFMAAAKI 387
           G+ ED   AA +
Sbjct: 305 GRMEDMRRAAAV 316