hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj24184/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4239  ( 1059 res)   mfj24184

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   237.8    9.1e-67   1
PH       Pleckstrin homology domain.                    130.3      2e-34   2
FYVE     Protein present in Fab1, YOTB, Vac1, and EEA   104.8    9.8e-27   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1     475   658 ..     1   211 []   237.8  9.1e-67
PH         1/2     689   789 ..     1    82 []    77.0  2.3e-18
FYVE       1/1     820   889 ..     1    81 []   104.8  9.8e-27
PH         2/2     920  1021 ..     1    82 []    53.3  3.1e-11

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 475 to 658: score 237.8, E = 9.1e-67
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      +++ELlqTE++YV  L++l++vf  +L++ea++ +   ++ d v+ +
   mKIAA4239   475    IANELLQTEKAYVSRLHLLDQVFCARLLEEARNRS--SFPADVVHGI 519  

                   FgpNieeiyefHrrFLd.eLeerveewllskdlKsernsviedsgerigd
                   F+ Ni +iy fH++FL++eLe+r+eew               d ++rigd
   mKIAA4239   520 FS-NICSIYCFHQQFLLpELEKRMEEW---------------DRYPRIGD 553  

                   vFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeies
                   +++kl   ++f+k+Y+eY++n+++a+el ++  +++ + +F+  + e+++
   mKIAA4239   554 ILQKL---APFLKMYGEYVKNFDRAVELVNT--WTERSTQFKVIIHEVQK 598  

                   kpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLk
                   ++ c+     +ltL++++++PvQR+++Y LLLk++l + p++++d +d++
   mKIAA4239   599 EEACG-----NLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQ 643  

                   kAleaikelasqvNe<-*
                   k le+i + a++ N+   
   mKIAA4239   644 KSLELIATAAEHSNA    658  

PH: domain 1 of 2, from 689 to 789: score 77.0, E = 2.3e-18
                   *->vikeGwLlkks..k.swkkryfvLfngvLlyyksk........kpkg
                      +ikeG++lk+s ++++ ++ry++Lfn++Lly+ ++ +  +++ + + 
   mKIAA4239   689    LIKEGHILKLSakNgTTQDRYLILFNDRLLYCVPRlrllgqkfSVRA 735  

                   sipLsgcsvre.p......cFeivt.drtlllqAeseeereeWvealqsa
                   +i+++g++++e+ + + +++F ++ ++r+l+lqA++eee+++Wv+a++s 
   mKIAA4239   736 RIDVDGMELKEsSnlnmprTFLVSGkQRSLELQARTEEEKKDWVQAINST 785  

                   iaka<-*
                   + k+   
   mKIAA4239   786 LLKH    789  

FYVE: domain 1 of 1, from 820 to 889: score 104.8, E = 9.8e-27
                   *->etaphWvpDeeasnClmnCgkeFtlvtrRrHHCRnCGrifCskCssk
                      ++ap+ ++++e+ +C m+C+++F+ +t+RrHHC +CG+++C+kCs++
   mKIAA4239   820    KRAPTPIREKEVTMC-MRCQEPFNSITKRRHHCKACGHVVCGKCSEF 865  

                   kaplpklgkekkngknedftpvRVCdsCyerlsk<-*
                   +a+l++++++          ++RVC +Cy+ l++   
   mKIAA4239   866 RARLIYDNNR----------SNRVCTDCYVALHG    889  

PH: domain 2 of 2, from 920 to 1021: score 53.3, E = 3.1e-11
                   *->vikeGwLlkks..k.swkkryfvLfn...gvLlyyksk...kpkgsi
                       +++ +L+ +++++++w+k +fv+ ++++ vL++y  +++ k + s+
   mKIAA4239   920    SVICSFLHYMEkgGkGWHKAWFVVPEnepLVLYIYGAPqdvKAQRSL 966  

                   pLsgcsvre.p.........cFeivt.drtlllqAeseeereeWvealqs
                   pL g +v +++ +++++++++F+i+ ++ +++++ e+ee +++W++ l +
   mKIAA4239   967 PLIGFEVGPpEagerpdrrhVFKITQsHLSWYFSPETEELQRRWMAVLGR 1016 

                   aiaka<-*
                   a +     
   mKIAA4239  1017 AGRGD    1021 

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