hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj24184/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4239  ( 1059 res)   mfj24184

Scores for sequence family classification (score includes all domains):
Model      Description                                  Score    E-value  N 
--------   -----------                                  -----    ------- ---
RhoGEF     RhoGEF domain                                299.9    3.2e-86   1
PH         PH domain                                    140.7    2.6e-38   2
FYVE       FYVE zinc finger                             110.9    2.4e-29   1
Extensin_2 Extensin-like region                        -134.0        0.3   1

Parsed for domains:
Model      Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------   ------- ----- -----    ----- -----      -----  -------
Extensin_2   1/1      36   375 ..     1   385 []  -134.0      0.3
RhoGEF       1/1     475   658 ..     1   207 []   299.9  3.2e-86
PH           1/2     689   787 ..     1    92 []    78.1  1.8e-19
FYVE         1/1     823   889 ..     1    77 []   110.9  2.4e-29
PH           2/2     920  1019 ..     1    92 []    62.6  8.6e-15

Alignments of top-scoring domains:
Extensin_2: domain 1 of 1, from 36 to 375: score -134.0, E = 0.3
                   *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy
                      ll + +   + +  s+ +   ++  PPP ++      PP   p    
   mKIAA4239    36    LLPPRLLAGARVGGSSLRSGAEPAAPPPEPEA---AAPPGAGP---- 75   

                   kSPPPpkkpYvYsSPPPPsyvykSPPPPkp......yvYkSPPpP...ky
                    SPP p          PP     S  P ++ + ++    + P  P+++ +
   mKIAA4239    76 -SPPAP----------PPQELEPSGEPGPRaqartmHGHRVPGGPgpsDP 114  

                   vYkSPPpPv..........ykYkSPPPPthsppPpyvykSPPPPpkkyvy
                     +   +P   +    ++++    P  P+ s         P  P+  +v 
   mKIAA4239   115 ERSAANTPGaaplacadsdPGALEPGLPV-SRGSGTALGGPLDPQ--FVG 161  

                   kSpPpptPvYkYkSPPPPpyvYkspPpPvkk.ripyvYkSPPPPpPYvYk
                    S             PP + v    P P +++  ++ Y            
   mKIAA4239   162 PSDASLG-------APPSSRVLPCGPSPQHHrALRFSY--------HLEG 196  

                   SpPppvkkyiyksppppephkYvYkSPPPPpPYvyesvpeqkikYvYkSP
                   S P+p    +++          +  S  P +       p+++ +   +S 
   mKIAA4239   197 SQPRPG---LHQGNRIL----VKSLSLDPGQ----SLEPHPEGPQRLRSD 235  

                   PPPkksYkspsppkyVYkSpPpPvipykYkSPPPPkkkyspaPrkpyvYk
                   P P+   + p p +   k +P P +    + PP P  +y   Pr+     
   mKIAA4239   236 PGPPT--EIPGPRPSPLKRAPGPKP----QVPPKP--SYLQMPRVL---- 273  

                   SPPPPtyvYkSpPpPykpptppkiyksPPPPtPvyvYkspPpippiksss
                     PPP ++   pPpP++p +  +       P       s+     i+   
   mKIAA4239   274 --PPPEPI---PPPPSRPLPADPRVAKGLVPRAEASTSSAAVSSLIEKFE 318  

                   ppPvyvYkSpPppvysPPPP.yvYssPPPPvyvynsaPvykksPPkhhYi
                    +Pv v    P p + P PP++   + PPP    +  P       +  + 
   mKIAA4239   319 REPVIVASDRPAPGPCPVPPePAMLPQPPPQPTGSQLP--EGEASRCLFL 366  

                   YsSPPPphh<-*
                    +  P       
   mKIAA4239   367 LAPGPRDGE    375  

RhoGEF: domain 1 of 1, from 475 to 658: score 299.9, E = 3.2e-86
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      +++Ell+TEk+Yv++L++ld+v++++L+e+a+++ +++++d+++ iF
   mKIAA4239   475    IANELLQTEKAYVSRLHLLDQVFCARLLEEARNR-SSFPADVVHGIF 520  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                   sNi++iy+fh++FL+++Le+r++++           ++++r+Gd+++kl 
   mKIAA4239   521 SNICSIYCFHQQFLLPELEKRMEEW-----------DRYPRIGDILQKL- 558  

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                   +pfl++YgeY++n+++A+el+++  ++++++qF+++++ev++++++g   
   mKIAA4239   559 APFLKMYGEYVKNFDRAVELVNT--WTERSTQFKVIIHEVQKEEACG--- 603  

                   davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkaldl
                      +ltLq+++l+PvqRi+rY+LLLk++L++ p+  ++pd++d++k+l+l
   mKIAA4239   604 ---NLTLQHHMLEPVQRIPRYELLLKDYLLKLPH--GSPDSKDAQKSLEL 648  

                   lqdlaksiNe<-*
                   ++++a+++N+   
   mKIAA4239   649 IATAAEHSNA    658  

PH: domain 1 of 2, from 689 to 787: score 78.1, E = 1.8e-19
                   *->vikeGwLlkkg.gkkswkkRyfvLfndvLlyykdkk......kkpkg
                      +ikeG++lk + ++++ ++Ry++Lfnd+Lly+ ++ +  +++++ + 
   mKIAA4239   689    LIKEGHILKLSaKNGTTQDRYLILFNDRLLYCVPRLrllgqkFSVRA 735  

                   sipLsgiqvekvpdnkrkncFeirt.dretlllqaeseeerkeWvkaiqs
                    i+++g+++++ ++ + + +F ++ ++r +l+lqa +eee+k+Wv+ai+s
   mKIAA4239   736 RIDVDGMELKESSNLNMPRTFLVSGkQR-SLELQARTEEEKKDWVQAINS 784  

                   air<-*
                    +    
   mKIAA4239   785 TLL    787  

FYVE: domain 1 of 1, from 823 to 889: score 110.9, E = 2.4e-29
                   *->phWvpDeevsnCmrCgkpFtkltkRrHHCRaCGrifCgsCssktvll
                      p+ + ++ev++CmrC++pF+++tkRrHHC+aCG+++Cg+Cs+++++l
   mKIAA4239   823    PTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARL 869  

                   pylgiaallkndviekpvRVCdsCydrlnk<-*
                    y++          +++ RVC +Cy  l++   
   mKIAA4239   870 IYDN----------NRSNRVCTDCYVALHG    889  

PH: domain 2 of 2, from 920 to 1019: score 62.6, E = 8.6e-15
                   *->vikeGwLlkkg.gkkswkkRyfvLfn...dvLlyykdkk.kkpkgsi
                       +++ +L+ +++g+k+w+k +fv+ ++++ vL++y  +++ k ++s+
   mKIAA4239   920    SVICSFLHYMEkGGKGWHKAWFVVPEnepLVLYIYGAPQdVKAQRSL 966  

                   pLsgiqvekvpdn...krkncFeirt.dretlllqaeseeerkeWvkaiq
                   pL g +v +++++++++r+++F+i+ ++  +++++ e+ee  ++W++ + 
   mKIAA4239   967 PLIGFEVGPPEAGerpDRRHVFKITQsHL-SWYFSPETEELQRRWMAVLG 1015 

                   sair<-*
                   +a r   
   mKIAA4239  1016 RAGR    1019 

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