hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mia/mia41047/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1362  ( 1407 res)   mia41047

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   168.8    5.3e-46   1
FYVE     Protein present in Fab1, YOTB, Vac1, and EEA   107.4    1.7e-27   1
PH       Pleckstrin homology domain.                     99.3    4.5e-25   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1     853  1037 ..     1   211 []   168.8  5.3e-46
PH         1/2    1068  1163 ..     1    82 []    65.3  7.6e-15
FYVE       1/1    1191  1259 ..     1    81 []   107.4  1.7e-27
PH         2/2    1311  1406 ..     1    82 []    34.1    2e-05

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 853 to 1037: score 168.8, E = 5.3e-46
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      ++kE++ +E+ +V+ Lk+l   f+ +    +++ ++p++ ++ ++++
   mKIAA1362   853    IAKEIMSSEKVFVDVLKLLHIDFRGAVAHASRQLGKPVIEDRILNQI 899  

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                    +  ++ +ye++r++L+eLeer+  w                 ++ri+d+
   mKIAA1362   900 LY-YLPQLYELNRDLLKELEERMLTW---------------TEQQRIADI 933  

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeiesk
                   F+k     +++k+Ys+Y++ +++ ++ll++  ++kknp F+++++e+e +
   mKIAA1362   934 FVKK---GPYLKMYSTYIKEFDKNVALLDE--QCKKNPGFAAVVREFEMS 978  

                   pncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLkk
                   p+c      +l L+++L+kPvQR+++Y LLL ++lk+  +d+ d+ d ++
   mKIAA1362   979 PRCA-----NLALKHYLLKPVQRIPQYRLLLTDYLKNLLEDSVDHRDTQD 1023 

                   AleaikelasqvNe<-*
                   Al+++ e+a++ N+   
   mKIAA1362  1024 ALAVVIEVANHAND    1037 

PH: domain 1 of 2, from 1068 to 1163: score 65.3, E = 7.6e-15
                   *->vikeGwLlkksk.swkkryfvLfngvLlyyksk.....kpkgsipLs
                      ++keG+L+k+s++  ++r f+Lfn+ Lly+ + +++  k+  +++L 
   mKIAA1362  1068    FLKEGTLMKLSRkVMQPRMFFLFNDALLYTTPMqsgmyKLNNMLSLA 1114 

                   gcsvre.p......cFeivt.drtlllqAeseeereeWvealqsaiaka<
                   g++vr+++ +   + ++i + +r+++l+A+s+ er++W+ea+ s i+++ 
   mKIAA1362  1115 GMKVRKpTqeayqnELKIESvERSFILSASSAAERDDWLEAISSSIEEY  1163 

                   -*
                     
   mKIAA1362     -    -    

FYVE: domain 1 of 1, from 1191 to 1259: score 107.4, E = 1.7e-27
                   *->etaphWvpDeeasnClmnCgkeFtlvtrRrHHCRnCGrifCskCssk
                       +ap W+pD +a +C m C  eFtl t RrHHCR+CG+i+C+ Css+
   mKIAA1362  1191    AKAPIWIPDTRATMC-MICTSEFTL-TWRRHHCRACGKIVCQACSSN 1235 

                   kaplpklgkekkngknedftpvRVCdsCyerlsk<-*
                   k  l++l+             +RVC +C+++l+k   
   mKIAA1362  1236 KYGLDYLKGQ----------LARVCEHCFQELQK    1259 

PH: domain 2 of 2, from 1311 to 1406: score 34.1, E = 2e-05
                   *->vikeGwLlkks..k.swkkryfvLfngvLlyyksk...kpkgsipLs
                       +++G+L++ +++k+ wk  +fv++n+vL+ y  +++ +  +s pL 
   mKIAA1362  1311    STMSGYLYRSKgsKkPWKHLWFVIKNKVLYTYAASedvAALESQPLL 1357 

                   gcsvre.p.......cFeivt.dr.tlllqAeseeereeWvealqsaiak
                   g +v+  +++++++++F++ +++   ++++A+++ + ++W++a+q+    
   mKIAA1362  1358 GFTVTLvKdenseskVFQLLHkGMvFYVFKADDAHSTQRWIDAFQE--GT 1405 

                   a<-*
                       
   mKIAA1362  1406 V    1406 

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