hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mia/mia41047/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1362  ( 1407 res)   mia41047

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   RhoGEF domain                                  127.8    2.1e-34   1
PH       PH domain                                      112.2    9.7e-30   2
FYVE     FYVE zinc finger                               104.0    2.9e-27   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1     853  1037 ..     1   207 []   127.8  2.1e-34
PH         1/2    1068  1161 ..     1    92 []    63.9  3.5e-15
FYVE       1/1    1194  1259 ..     1    77 []   104.0  2.9e-27
PH         2/2    1311  1406 ..     1    92 []    48.4  1.6e-10

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 853 to 1037: score 127.8, E = 2.1e-34
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaiss.kpvltpddieti
                      ++kE++ +Ek +v+ L +l  +++  +  a++  +kpv+  + ++ i
   mKIAA1362   853    IAKEIMSSEKVFVDVLKLLHIDFRGAVAHASRQLgKPVIEDRILNQI 899  

                   FsNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlkl
                      ++ +ye++r++Lk +Le+r+ ++            ++qr++d+F k 
   mKIAA1362   900 LYYLPQLYELNRDLLK-ELEERMLTW-----------TEQQRIADIFVKK 937  

                   kepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAk
                     p l++Y  Y++ ++  + ll+   q+++np Fa ++ e e s+ +   
   mKIAA1362   938 -GPYLKMYSTYIKEFDKNVALLDE--QCKKNPGFAAVVREFEMSPRCA-- 982  

                   ddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkald
                       +l L ++LlkPvqRi+ Y LLL ++Lk   e  d+ d+ d ++al+
   mKIAA1362   983 ----NLALKHYLLKPVQRIPQYRLLLTDYLKNLLE--DSVDHRDTQDALA 1026 

                   llqdlaksiNe<-*
                    + ++a++ N+   
   mKIAA1362  1027 VVIEVANHAND    1037 

PH: domain 1 of 2, from 1068 to 1161: score 63.9, E = 3.5e-15
                   *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk...kkpkgsipL
                        keG L+k + +k  ++R f+Lfnd Lly  + +++ +k+  +++L
   mKIAA1362  1068    FLKEGTLMKLS-RKVMQPRMFFLFNDALLYTTPMQsgmYKLNNMLSL 1113 

                   sgiqvekvpdnkrkncFeirt.dretlllqaeseeerkeWvkaiqsair<
                    g++v+k++    +n ++i + +r +++l+a+s+ er++W++ai+s+i+ 
   mKIAA1362  1114 AGMKVRKPTQEAYQNELKIESvER-SFILSASSAAERDDWLEAISSSIE  1161 

                   -*
                     
   mKIAA1362     -    -    

FYVE: domain 1 of 1, from 1194 to 1259: score 104.0, E = 2.9e-27
                   *->phWvpDeevsnCmrCgkpFtkltkRrHHCRaCGrifCgsCssktvll
                      p W+pD  +++Cm+C  +Ft lt RrHHCRaCG+i+C+ Css++  l
   mKIAA1362  1194    PIWIPDTRATMCMICTSEFT-LTWRRHHCRACGKIVCQACSSNKYGL 1239 

                   pylgiaallkndviekpvRVCdsCydrlnk<-*
                   +yl          + + +RVC++C++ l+k   
   mKIAA1362  1240 DYL----------KGQLARVCEHCFQELQK    1259 

PH: domain 2 of 2, from 1311 to 1406: score 48.4, E = 1.6e-10
                   *->vikeGwLlkkg.gkkswkkRyfvLfndvLlyykdkk.kkpkgsipLs
                       +++G+L++  ++kk wk  +fv++n+vL+ y  + +     s pL 
   mKIAA1362  1311    STMSGYLYRSKgSKKPWKHLWFVIKNKVLYTYAASEdVAALESQPLL 1357 

                   giqvekvpdn.krkncFeirt.dretlllqaeseeerkeWvkaiqsair<
                   g +v+ v+d + +  +F++ +++   ++++a+++ + ++W++a+q+    
   mKIAA1362  1358 GFTVTLVKDEnSESKVFQLLHkGMVFYVFKADDAHSTQRWIDAFQEGTV  1406 

                   -*
                     
   mKIAA1362     -    -    

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