Result of FASTA (omim) for pF1KB0475
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB0475, 517 aa
  1>>>pF1KB0475 517 - 517 aa - 517 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.4670+/-0.000403; mu= 14.9462+/- 0.025
 mean_var=172.5963+/-36.130, 0's: 0 Z-trim(117.4): 226  B-trim: 7 in 2/53
 Lambda= 0.097624
 statistics sampled from 29108 (29402) to 29108 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.345), width:  16
 Scan time:  9.170

The best scores are:                                      opt bits E(85289)
NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 ( 517) 3505 506.3 9.1e-143
NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 ( 458) 2272 332.5 1.6e-90
NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 ( 352) 2249 329.2 1.3e-89
XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 is ( 510)  748 117.9   7e-26
NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Ho ( 487)  747 117.8 7.5e-26
XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 is ( 541)  747 117.8 8.1e-26
NP_056295 (OMIM: 607147) nectin-3 isoform 1 precur ( 549)  718 113.8 1.4e-24
XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 is ( 526)  717 113.6 1.5e-24
XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 is ( 534)  717 113.6 1.5e-24
XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 is ( 580)  717 113.6 1.6e-24
NP_001230215 (OMIM: 607147) nectin-3 isoform 2 pre ( 366)  709 112.3 2.6e-24
NP_001129242 (OMIM: 173850) poliovirus receptor is ( 392)  650 104.0 8.5e-22
NP_006496 (OMIM: 173850) poliovirus receptor isofo ( 417)  650 104.0 8.9e-22
NP_001129240 (OMIM: 173850) poliovirus receptor is ( 372)  633 101.6 4.3e-21
NP_001129241 (OMIM: 173850) poliovirus receptor is ( 364)  615 99.0 2.5e-20
NP_002847 (OMIM: 600798) nectin-2 isoform alpha pr ( 479)  614 99.0 3.2e-20
NP_001036189 (OMIM: 600798) nectin-2 isoform delta ( 538)  569 92.8 2.8e-18
XP_011508324 (OMIM: 609607,613573) PREDICTED: nect ( 486)  555 90.7   1e-17
XP_011508325 (OMIM: 609607,613573) PREDICTED: nect ( 460)  552 90.3 1.3e-17
XP_011508323 (OMIM: 609607,613573) PREDICTED: nect ( 511)  552 90.3 1.4e-17
XP_005245565 (OMIM: 609607,613573) PREDICTED: nect ( 485)  545 89.3 2.8e-17
NP_112178 (OMIM: 609607,613573) nectin-4 precursor ( 510)  542 88.9 3.8e-17
XP_011525494 (OMIM: 600798) PREDICTED: nectin-2 is ( 369)  530 87.1   1e-16
XP_016861616 (OMIM: 607147) PREDICTED: nectin-3 is ( 337)  421 71.7   4e-12
XP_005271551 (OMIM: 605686) PREDICTED: cell adhesi ( 425)  347 61.4 6.3e-09
NP_001091987 (OMIM: 605686) cell adhesion molecule ( 414)  323 58.0 6.4e-08
NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398)  318 57.3   1e-07
NP_067012 (OMIM: 609743) cell adhesion molecule 3  ( 432)  318 57.3 1.1e-07
XP_016872947 (OMIM: 605686) PREDICTED: cell adhesi ( 402)  310 56.1 2.3e-07
NP_055148 (OMIM: 605686) cell adhesion molecule 1  ( 442)  310 56.2 2.4e-07
NP_001287973 (OMIM: 605686) cell adhesion molecule ( 453)  303 55.2 4.8e-07
NP_001287972 (OMIM: 605686) cell adhesion molecule ( 471)  303 55.2 4.9e-07
XP_016872946 (OMIM: 605686) PREDICTED: cell adhesi ( 477)  303 55.2   5e-07
XP_016881941 (OMIM: 609744) PREDICTED: cell adhesi ( 369)  300 54.7 5.7e-07
NP_001287974 (OMIM: 605686) cell adhesion molecule ( 443)  301 54.9 5.8e-07
NP_660339 (OMIM: 609744) cell adhesion molecule 4  ( 388)  300 54.7 5.8e-07
XP_005258677 (OMIM: 609744) PREDICTED: cell adhesi ( 345)  256 48.4   4e-05
XP_006713145 (OMIM: 609938) PREDICTED: cell adhesi ( 395)  253 48.1 5.8e-05
XP_016861552 (OMIM: 609938) PREDICTED: cell adhesi ( 397)  253 48.1 5.8e-05
NP_001161147 (OMIM: 609938) cell adhesion molecule ( 404)  253 48.1 5.9e-05
NP_001161146 (OMIM: 609938) cell adhesion molecule ( 435)  244 46.9 0.00015
XP_006713144 (OMIM: 609938) PREDICTED: cell adhesi ( 435)  244 46.9 0.00015
NP_694854 (OMIM: 609938) cell adhesion molecule 2  ( 437)  244 46.9 0.00015
XP_016861551 (OMIM: 609938) PREDICTED: cell adhesi ( 449)  244 46.9 0.00015
XP_016872950 (OMIM: 605686) PREDICTED: cell adhesi ( 267)  240 46.1 0.00016
XP_016872949 (OMIM: 605686) PREDICTED: cell adhesi ( 295)  227 44.3 0.00061
XP_016872948 (OMIM: 605686) PREDICTED: cell adhesi ( 324)  220 43.3  0.0013


>>NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 pre  (517 aa)
 initn: 3505 init1: 3505 opt: 3505  Z-score: 2684.1  bits: 506.3 E(85289): 9.1e-143
Smith-Waterman score: 3505; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517)

               10        20        30        40        50        60
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB0 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB0 DSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDG
              430       440       450       460       470       480

              490       500       510       
pF1KB0 YGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
       :::::::::::::::::::::::::::::::::::::
NP_002 YGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
              490       500       510       

>>NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 pre  (458 aa)
 initn: 2276 init1: 2250 opt: 2272  Z-score: 1746.2  bits: 332.5 E(85289): 1.6e-90
Smith-Waterman score: 2279; 76.4% identity (83.7% similar) in 479 aa overlap (1-477:1-454)

               10        20        30        40        50        60
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
       ::::::::::::::::::::::::::::::::::: :     :..:   : .   . : :
NP_976 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEKPR----PQRG--LGSAARLLAGTV
              310       320       330           340         350    

              370       380       390       400       410          
pF1KB0 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHP-PMAQNLQYP
       :  ..:.:..:  .     :....         .. : : ..    . .: :  :.   :
NP_976 A--VFLILVAVLTVFFLYNRQQKS-------PPETDGAGTDQPLSQKPEPSPSRQSSLVP
            360       370              380       390       400     

     420       430       440       450       460        470        
pF1KB0 DDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYF-TVDEAEARQ
       .: .   .  :  : . ..:::. .       :..   : ::  ..  :  .:  .: : 
NP_976 EDIQ-VVHLDP--GRQQQQEEEDLQ-------KLSLQPPYYDLGVSPSYHPSVRTTEPRG
          410         420              430       440       450     

      480       490       500       510       
pF1KB0 DGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
                                              
NP_976 ECP                                    
                                              

>>NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 pre  (352 aa)
 initn: 2249 init1: 2249 opt: 2249  Z-score: 1729.9  bits: 329.2 E(85289): 1.3e-89
Smith-Waterman score: 2249; 96.8% identity (97.1% similar) in 349 aa overlap (1-349:1-349)

               10        20        30        40        50        60
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
       :::::::::::::::::::::::::::::::::: :     : .   ::           
NP_976 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITAFCQLIYPGKGRTRARMF        
              310       320       330       340       350          

              370       380       390       400       410       420
pF1KB0 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPD

>>XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 isofor  (510 aa)
 initn: 658 init1: 308 opt: 748  Z-score: 585.6  bits: 117.9 E(85289): 7e-26
Smith-Waterman score: 756; 32.4% identity (61.6% similar) in 438 aa overlap (25-448:52-471)

                     10        20        30        40        50    
pF1KB0       MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFA
                                     : :. .  . :.  . .  : .: :.: . 
XP_016 ASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIE
              30        40        50        60        70        80 

           60        70        80        90       100       110    
pF1KB0 NPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRL
           .  :::..:.:  . :.:.::...:..: :: . :. :: :   :..:.:: :  .
XP_016 V---NETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNI
                 90       100       110       120       130        

          120       130       140        150       160       170   
pF1KB0 ELEDEGVYICEFATFPTGNRESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCT
        . : : :::. .::: :: .:. ..::...:: . :.: ....    : .. : .: : 
XP_016 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICI
      140       150       160       170       180           190    

           180       190       200       210       220       230   
pF1KB0 SANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-M
       .:.::: . ..::  : :: :      :: :.:.::.:.: :.: :. . ..:.:..  .
XP_016 AATGKPVAHIDWEGDL-GEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPAL
          200       210        220       230       240       250   

             240       250       260       270       280       290 
pF1KB0 DR-FKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPK
       .. .. :. :..:: :::.. :.::::.. :  :.: :.::::::  .  :. :.:. : 
XP_016 EKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPD
           260       270       280       290       300       310   

             300       310       320       330       340       350 
pF1KB0 GVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGP
       :. :.. :: :  :.... .:.:::..:: .: :: :  . :.. :.  .          
XP_016 GLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDVPFKQTSS--------
           320       330       340       350       360             

             360       370         380         390       400       
pF1KB0 VPTAIIGGVAGSILLVLIVVGGIVVAL--RRRRHTF--KGDYSTKKHVYGNGYSKAGIPQ
          :. :.: :..: ..:..  ..: :  :..: ..  :       :     : . . : 
XP_016 --IAVAGAVIGAVLALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPL
           370       380       390       400       410       420   

       410       420        430             440       450       460
pF1KB0 HHPPMAQNLQYPDDSD-DEKKAGPLGGS------SYEEEEEEEEGGGGGERKVGGPHPKY
        .  . :  . : ...  :...: :  :      :.. :.:.  :  :            
XP_016 PQKDLFQPEHLPLQTQFKEREVGNLQHSNGLNSRSFDYEDENPVGEDGIQQMYPLYNQMC
           430       440       450       460       470       480   

              470       480       490       500       510       
pF1KB0 DEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
                                                                
XP_016 YQDRSPGKHHQNNDPKRVYIDPREHYV                              
           490       500       510                              

>>NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Homo s  (487 aa)
 initn: 658 init1: 308 opt: 747  Z-score: 585.1  bits: 117.8 E(85289): 7.5e-26
Smith-Waterman score: 755; 33.2% identity (63.2% similar) in 419 aa overlap (44-448:48-448)

            20        30        40        50        60        70   
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
                                     : .: :.: .     .  :::..:.:  . 
NP_001 RGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLIEV---NETITQISWEKIHGK
        20        30        40        50           60        70    

            80        90       100       110       120       130   
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
       :.:.::...:..: :: . :. :: :   :..:.:: :  . . : : :::. .::: ::
NP_001 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
           80        90       100       110       120       130    

           140        150       160       170       180       190  
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
        .:. ..::...:: . :.: ....    : .. : .: : .:.::: . ..::  : ::
NP_001 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
          140       150          160        170       180          

            200       210       220       230         240       250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
        :      :: :.:.::.:.: :.: :. . ..:.:..  ... .. :. :..:: :::.
NP_001 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
     190       200       210       220       230       240         

              260       270       280       290       300       310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
       . :.::::.. :  :.: :.::::::  .  :. :.:. : :. :.. :: :  :.... 
NP_001 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
     250       260       270       280       290       300         

              320       330       340       350       360       370
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIV
       .:.:::..:: .: :: :  . :.. :.        .... .  :. :.: :..: ..:.
NP_001 SGVYICKVTNSLGQRSDQKVIYISDVPF--------KQTSSI--AVAGAVIGAVLALFII
     310       320       330               340         350         

                380         390       400       410       420      
pF1KB0 VGGIVVAL--RRRRHTF--KGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSD-DE
       .  ..: :  :..: ..  :       :     : . . :  .  . :  . : ...  :
NP_001 AIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEHLPLQTQFKE
     360       370       380       390       400       410         

         430             440       450       460       470         
pF1KB0 KKAGPLGGS------SYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQD
       ...: :  :      :.. :.:.  :  :                               
NP_001 REVGNLQHSNGLNSRSFDYEDENPVGEDGIQQMYPLYNQMCYQDRSPGKHHQNNDPKRVY
     420       430       440       450       460       470         

>>XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 isofor  (541 aa)
 initn: 658 init1: 308 opt: 747  Z-score: 584.5  bits: 117.8 E(85289): 8.1e-26
Smith-Waterman score: 755; 33.2% identity (63.2% similar) in 419 aa overlap (44-448:102-502)

            20        30        40        50        60        70   
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
                                     : .: :.: .     .  :::..:.:  . 
XP_016 ILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLIEV---NETITQISWEKIHGK
              80        90       100       110          120        

            80        90       100       110       120       130   
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
       :.:.::...:..: :: . :. :: :   :..:.:: :  . . : : :::. .::: ::
XP_016 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
      130       140       150       160       170       180        

           140        150       160       170       180       190  
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
        .:. ..::...:: . :.: ....    : .. : .: : .:.::: . ..::  : ::
XP_016 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
      190       200       210          220        230       240    

            200       210       220       230         240       250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
        :      :: :.:.::.:.: :.: :. . ..:.:..  ... .. :. :..:: :::.
XP_016 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
           250       260       270       280       290       300   

              260       270       280       290       300       310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
       . :.::::.. :  :.: :.::::::  .  :. :.:. : :. :.. :: :  :.... 
XP_016 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
           310       320       330       340       350       360   

              320       330       340       350       360       370
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIV
       .:.:::..:: .: :: :  . :.. :.        .... .  :. :.: :..: ..:.
XP_016 SGVYICKVTNSLGQRSDQKVIYISDVPF--------KQTSSI--AVAGAVIGAVLALFII
           370       380       390                 400       410   

                380         390       400       410       420      
pF1KB0 VGGIVVAL--RRRRHTF--KGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSD-DE
       .  ..: :  :..: ..  :       :     : . . :  .  . :  . : ...  :
XP_016 AIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEHLPLQTQFKE
           420       430       440       450       460       470   

         430             440       450       460       470         
pF1KB0 KKAGPLGGS------SYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQD
       ...: :  :      :.. :.:.  :  :                               
XP_016 REVGNLQHSNGLNSRSFDYEDENPVGEDGIQQMYPLYNQMCYQDRSPGKHHQNNDPKRVY
           480       490       500       510       520       530   

>>NP_056295 (OMIM: 607147) nectin-3 isoform 1 precursor   (549 aa)
 initn: 786 init1: 308 opt: 718  Z-score: 562.4  bits: 113.8 E(85289): 1.4e-24
Smith-Waterman score: 833; 32.8% identity (60.3% similar) in 527 aa overlap (25-517:52-549)

                     10        20        30        40        50    
pF1KB0       MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFA
                                     : :. .  . :.  . .  : .: :.: . 
NP_056 ASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIE
              30        40        50        60        70        80 

           60        70        80        90       100       110    
pF1KB0 NPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRL
           .  :::..:.:  . :.:.::...:..: :: . :. :: :   :..:.:: :  .
NP_056 ---VNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNI
                 90       100       110       120       130        

          120       130       140        150       160       170   
pF1KB0 ELEDEGVYICEFATFPTGNRESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCT
        . : : :::. .::: :: .:. ..::...:: . :.: ....    : .. : .: : 
NP_056 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICI
      140       150       160       170       180           190    

           180       190       200       210       220       230   
pF1KB0 SANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-M
       .:.::: . ..::  : :: :      :: :.:.::.:.: :.: :. . ..:.:..  .
NP_056 AATGKPVAHIDWEGDL-GEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPAL
          200       210        220       230       240       250   

             240       250       260       270       280       290 
pF1KB0 DR-FKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPK
       .. .. :. :..:: :::.. :.::::.. :  :.: :.::::::  .  :. :.:. : 
NP_056 EKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPD
           260       270       280       290       300       310   

             300       310       320       330           340       
pF1KB0 GVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGR
       :. :.. :: :  :.... .:.:::..:: .: :: :  . :.. : :    :.   :  
NP_056 GLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPS
           320       330       340       350       360       370   

       350                               360       370       380   
pF1KB0 RAG-----------PVP-------------TAIIGGVAGSILLVLIVVGGIVVALRRRRH
        :            : :             : : . :.:....::. : . .   :::: 
NP_056 TADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-
           380       390       400       410       420       430   

           390       400       410        420       430       440  
pF1KB0 TFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEE
       ::.::: .:...  . ..: .  :    . ..:. :::.   :.: .:...   ..  ::
NP_056 TFRGDYFAKNYIPPSDMQKES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEE
            440       450         460       470        480         

            450       460       470       480       490        500 
pF1KB0 EEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-
        :       :.   . .  .  .::.          : : :  .:... . :. :  :. 
NP_056 PE-------KTQWNNVENLNRFERPM----------DYYEDLKMGMKFVSDEHYDENEDD
     490              500                 510       520       530  

              510       
pF1KB0 MVSQNDGSFISKKEWYV
       .::. ::: ::..::::
NP_056 LVSHVDGSVISRREWYV
            540         

>>XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 isofor  (526 aa)
 initn: 786 init1: 308 opt: 717  Z-score: 561.8  bits: 113.6 E(85289): 1.5e-24
Smith-Waterman score: 832; 33.5% identity (60.8% similar) in 508 aa overlap (44-517:48-526)

            20        30        40        50        60        70   
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
                                     : .: :.: .     .  :::..:.:  . 
XP_016 RGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLIE---VNETITQISWEKIHGK
        20        30        40        50           60        70    

            80        90       100       110       120       130   
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
       :.:.::...:..: :: . :. :: :   :..:.:: :  . . : : :::. .::: ::
XP_016 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
           80        90       100       110       120       130    

           140        150       160       170       180       190  
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
        .:. ..::...:: . :.: ....    : .. : .: : .:.::: . ..::  : ::
XP_016 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
          140       150          160        170       180          

            200       210       220       230         240       250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
        :      :: :.:.::.:.: :.: :. . ..:.:..  ... .. :. :..:: :::.
XP_016 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
     190       200       210       220       230       240         

              260       270       280       290       300       310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
       . :.::::.. :  :.: :.::::::  .  :. :.:. : :. :.. :: :  :.... 
XP_016 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
     250       260       270       280       290       300         

              320       330           340       350                
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGRRAG-----------PVP--
       .:.:::..:: .: :: :  . :.. : :    :.   :   :            : :  
XP_016 SGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
     310       320       330       340       350       360         

                      360       370       380       390       400  
pF1KB0 -----------TAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK
                  : : . :.:....::. : . .   :::: ::.::: .:...  . ..:
XP_016 TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-TFRGDYFAKNYIPPSDMQK
     370       380       390       400        410       420        

            410        420       430       440       450       460 
pF1KB0 AGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYD
        .  :    . ..:. :::.   :.: .:...   ..  :: :       :.   . .  
XP_016 ES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEEPE-------KTQWNNVENL
      430         440       450        460              470        

             470       480       490        500        510       
pF1KB0 EDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-MVSQNDGSFISKKEWYV
       .  .::.          : : :  .:... . :. :  :. .::. ::: ::..::::
XP_016 NRFERPM----------DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
      480                 490       500       510       520      

>>XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 isofor  (534 aa)
 initn: 786 init1: 308 opt: 717  Z-score: 561.8  bits: 113.6 E(85289): 1.5e-24
Smith-Waterman score: 832; 33.5% identity (60.8% similar) in 508 aa overlap (44-517:56-534)

            20        30        40        50        60        70   
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
                                     : .: :.: .     .  :::..:.:  . 
XP_016 ILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLIE---VNETITQISWEKIHGK
          30        40        50        60           70        80  

            80        90       100       110       120       130   
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
       :.:.::...:..: :: . :. :: :   :..:.:: :  . . : : :::. .::: ::
XP_016 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
             90       100       110       120       130       140  

           140        150       160       170       180       190  
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
        .:. ..::...:: . :.: ....    : .. : .: : .:.::: . ..::  : ::
XP_016 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
            150       160          170        180       190        

            200       210       220       230         240       250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
        :      :: :.:.::.:.: :.: :. . ..:.:..  ... .. :. :..:: :::.
XP_016 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
       200       210       220       230       240       250       

              260       270       280       290       300       310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
       . :.::::.. :  :.: :.::::::  .  :. :.:. : :. :.. :: :  :.... 
XP_016 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
       260       270       280       290       300       310       

              320       330           340       350                
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGRRAG-----------PVP--
       .:.:::..:: .: :: :  . :.. : :    :.   :   :            : :  
XP_016 SGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
       320       330       340       350       360       370       

                      360       370       380       390       400  
pF1KB0 -----------TAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK
                  : : . :.:....::. : . .   :::: ::.::: .:...  . ..:
XP_016 TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-TFRGDYFAKNYIPPSDMQK
       380       390       400       410        420       430      

            410        420       430       440       450       460 
pF1KB0 AGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYD
        .  :    . ..:. :::.   :.: .:...   ..  :: :       :.   . .  
XP_016 ES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEEPE-------KTQWNNVENL
          440       450       460        470              480      

             470       480       490        500        510       
pF1KB0 EDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-MVSQNDGSFISKKEWYV
       .  .::.          : : :  .:... . :. :  :. .::. ::: ::..::::
XP_016 NRFERPM----------DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
        490                 500       510       520       530    

>>XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 isofor  (580 aa)
 initn: 786 init1: 308 opt: 717  Z-score: 561.4  bits: 113.6 E(85289): 1.6e-24
Smith-Waterman score: 832; 33.5% identity (60.8% similar) in 508 aa overlap (44-517:102-580)

            20        30        40        50        60        70   
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
                                     : .: :.: .     .  :::..:.:  . 
XP_011 ILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLIE---VNETITQISWEKIHGK
              80        90       100       110          120        

            80        90       100       110       120       130   
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
       :.:.::...:..: :: . :. :: :   :..:.:: :  . . : : :::. .::: ::
XP_011 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
      130       140       150       160       170       180        

           140        150       160       170       180       190  
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
        .:. ..::...:: . :.: ....    : .. : .: : .:.::: . ..::  : ::
XP_011 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
      190       200       210          220        230       240    

            200       210       220       230         240       250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
        :      :: :.:.::.:.: :.: :. . ..:.:..  ... .. :. :..:: :::.
XP_011 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
           250       260       270       280       290       300   

              260       270       280       290       300       310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
       . :.::::.. :  :.: :.::::::  .  :. :.:. : :. :.. :: :  :.... 
XP_011 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
           310       320       330       340       350       360   

              320       330           340       350                
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGRRAG-----------PVP--
       .:.:::..:: .: :: :  . :.. : :    :.   :   :            : :  
XP_011 SGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
           370       380       390       400       410       420   

                      360       370       380       390       400  
pF1KB0 -----------TAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK
                  : : . :.:....::. : . .   :::: ::.::: .:...  . ..:
XP_011 TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-TFRGDYFAKNYIPPSDMQK
           430       440       450       460        470       480  

            410        420       430       440       450       460 
pF1KB0 AGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYD
        .  :    . ..:. :::.   :.: .:...   ..  :: :       :.   . .  
XP_011 ES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEEPE-------KTQWNNVENL
              490       500        510       520              530  

             470       480       490        500        510       
pF1KB0 EDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-MVSQNDGSFISKKEWYV
       .  .::.          : : :  .:... . :. :  :. .::. ::: ::..::::
XP_011 NRFERPM----------DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
                      540       550       560       570       580




517 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 17:03:32 2016 done: Sat Nov  5 17:03:33 2016
 Total Scan time:  9.170 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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