Result of FASTA (omim) for pF1KSDA0053
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0053, 638 aa
  1>>>pF1KSDA0053 638 - 638 aa - 638 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.7141+/-0.000438; mu= 5.5968+/- 0.027
 mean_var=260.9238+/-54.511, 0's: 0 Z-trim(118.8): 358  B-trim: 1055 in 1/53
 Lambda= 0.079399
 statistics sampled from 31715 (32141) to 31715 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.377), width:  16
 Scan time:  9.550

The best scores are:                                      opt bits E(85289)
NP_055697 (OMIM: 610587) rho GTPase-activating pro ( 638) 4247 500.3 8.7e-141
NP_001159748 (OMIM: 610587) rho GTPase-activating  ( 639) 4235 498.9 2.3e-140
XP_016860913 (OMIM: 610587) PREDICTED: rho GTPase- ( 649) 4178 492.4 2.1e-138
XP_005264732 (OMIM: 610587) PREDICTED: rho GTPase- ( 645) 4169 491.3 4.3e-138
XP_016860912 (OMIM: 610587) PREDICTED: rho GTPase- ( 650) 4166 491.0 5.5e-138
NP_001007232 (OMIM: 610587) rho GTPase-activating  ( 646) 4157 490.0 1.1e-137
XP_011531509 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 4118 485.5 2.4e-136
XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 4118 485.5 2.4e-136
XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 4118 485.5 2.4e-136
XP_005264733 (OMIM: 610587) PREDICTED: rho GTPase- ( 607) 3230 383.8 9.9e-106
XP_016860914 (OMIM: 610587) PREDICTED: rho GTPase- ( 611) 3230 383.8 9.9e-106
NP_001159749 (OMIM: 610587) rho GTPase-activating  ( 606) 3228 383.5 1.2e-105
XP_011531511 (OMIM: 610587) PREDICTED: rho GTPase- ( 528) 3226 383.2 1.2e-105
XP_011531512 (OMIM: 610587) PREDICTED: rho GTPase- ( 372) 2426 291.4 3.7e-78
XP_016860915 (OMIM: 610587) PREDICTED: rho GTPase- ( 372) 2426 291.4 3.7e-78
XP_016860916 (OMIM: 610587) PREDICTED: rho GTPase- ( 372) 2426 291.4 3.7e-78
XP_016860917 (OMIM: 610587) PREDICTED: rho GTPase- ( 313) 1713 209.7 1.3e-53
NP_067049 (OMIM: 610585) rho GTPase-activating pro ( 698) 1351 168.6 6.8e-41
XP_011538306 (OMIM: 610585) PREDICTED: rho GTPase- ( 704) 1346 168.0   1e-40
NP_001242954 (OMIM: 610585) rho GTPase-activating  ( 704) 1346 168.0   1e-40
NP_001020787 (OMIM: 610586) rho GTPase-activating  ( 748) 1239 155.8 5.2e-37
XP_016871965 (OMIM: 610585) PREDICTED: rho GTPase- ( 414) 1181 148.9 3.4e-35
XP_016871962 (OMIM: 610585) PREDICTED: rho GTPase- ( 420) 1176 148.3 5.2e-35
NP_001242955 (OMIM: 610585) rho GTPase-activating  ( 608) 1031 131.9 6.7e-30
XP_011538313 (OMIM: 610585) PREDICTED: rho GTPase- ( 565)  962 123.9 1.5e-27
NP_001274734 (OMIM: 610586) rho GTPase-activating  ( 663)  963 124.1 1.6e-27
XP_005270071 (OMIM: 610585) PREDICTED: rho GTPase- ( 624)  955 123.2 2.8e-27
XP_011538307 (OMIM: 610585) PREDICTED: rho GTPase- ( 624)  955 123.2 2.8e-27
XP_011538309 (OMIM: 610585) PREDICTED: rho GTPase- ( 637)  955 123.2 2.9e-27
NP_001242953 (OMIM: 610585) rho GTPase-activating  ( 714)  955 123.2 3.1e-27
XP_011538304 (OMIM: 610585) PREDICTED: rho GTPase- ( 720)  955 123.2 3.1e-27
XP_011538305 (OMIM: 610585) PREDICTED: rho GTPase- ( 720)  955 123.2 3.1e-27
XP_011530602 (OMIM: 610586) PREDICTED: rho GTPase- ( 653)  952 122.8 3.7e-27
NP_001036134 (OMIM: 610586) rho GTPase-activating  ( 653)  952 122.8 3.7e-27
XP_016871959 (OMIM: 610585) PREDICTED: rho GTPase- ( 655)  952 122.9 3.7e-27
XP_011538308 (OMIM: 610585) PREDICTED: rho GTPase- ( 661)  952 122.9 3.7e-27
XP_016871961 (OMIM: 610585) PREDICTED: rho GTPase- ( 552)  949 122.4 4.2e-27
XP_016871960 (OMIM: 610585) PREDICTED: rho GTPase- ( 552)  949 122.4 4.2e-27
XP_011538314 (OMIM: 610585) PREDICTED: rho GTPase- ( 552)  949 122.4 4.2e-27
NP_112595 (OMIM: 610586) rho GTPase-activating pro ( 655)  860 112.3 5.5e-24
XP_011538315 (OMIM: 610585) PREDICTED: rho GTPase- ( 436)  785 103.5 1.6e-21
XP_011538317 (OMIM: 610585) PREDICTED: rho GTPase- ( 359)  775 102.3 3.1e-21
NP_001333022 (OMIM: 610586) rho GTPase-activating  ( 555)  537 75.2 6.8e-13
NP_001287881 (OMIM: 606524) SLIT-ROBO Rho GTPase-a ( 789)  329 51.6 1.3e-05
XP_005277572 (OMIM: 606524) PREDICTED: SLIT-ROBO R ( 789)  329 51.6 1.3e-05
XP_005277571 (OMIM: 606524) PREDICTED: SLIT-ROBO R ( 790)  329 51.6 1.3e-05
XP_016856330 (OMIM: 606524) PREDICTED: SLIT-ROBO R ( 840)  329 51.6 1.3e-05
XP_011507661 (OMIM: 606524) PREDICTED: SLIT-ROBO R ( 841)  329 51.6 1.3e-05
XP_016878879 (OMIM: 608293) PREDICTED: rho GTPase- ( 794)  328 51.5 1.4e-05
XP_016856327 (OMIM: 606524) PREDICTED: SLIT-ROBO R ( 931)  329 51.6 1.4e-05


>>NP_055697 (OMIM: 610587) rho GTPase-activating protein  (638 aa)
 initn: 4247 init1: 4247 opt: 4247  Z-score: 2648.5  bits: 500.3 E(85289): 8.7e-141
Smith-Waterman score: 4247; 100.0% identity (100.0% similar) in 638 aa overlap (1-638:1-638)

               10        20        30        40        50        60
pF1KSD MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD SYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD LEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD PWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD SVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQK
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD NDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPRE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD KPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD QDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSGE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD EEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALE
              550       560       570       580       590       600

              610       620       630        
pF1KSD ISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       ::::::::::::::::::::::::::::::::::::::
NP_055 ISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
              610       620       630        

>>NP_001159748 (OMIM: 610587) rho GTPase-activating prot  (639 aa)
 initn: 4233 init1: 3226 opt: 4235  Z-score: 2641.1  bits: 498.9 E(85289): 2.3e-140
Smith-Waterman score: 4235; 99.8% identity (99.8% similar) in 639 aa overlap (1-638:1-639)

               10        20        30        40        50        60
pF1KSD MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
               70        80        90       100       110       120

              130       140        150       160       170         
pF1KSD SYVLMASSQAEMEEWVKFLRRVAGTPCG-VFGQRLDETVAYEQKFGPHLVPILVEKCAEF
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_001 SYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHLVPILVEKCAEF
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KSD ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
              190       200       210       220       230       240

     240       250       260       270       280       290         
pF1KSD VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
              250       260       270       280       290       300

     300       310       320       330       340       350         
pF1KSD MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
              310       320       330       340       350       360

     360       370       380       390       400       410         
pF1KSD KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
              370       380       390       400       410       420

     420       430       440       450       460       470         
pF1KSD EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
              430       440       450       460       470       480

     480       490       500       510       520       530         
pF1KSD SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
              490       500       510       520       530       540

     540       550       560       570       580       590         
pF1KSD EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
              550       560       570       580       590       600

     600       610       620       630        
pF1KSD EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::
NP_001 EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
              610       620       630         

>>XP_016860913 (OMIM: 610587) PREDICTED: rho GTPase-acti  (649 aa)
 initn: 4166 init1: 4166 opt: 4178  Z-score: 2605.7  bits: 492.4 E(85289): 2.1e-138
Smith-Waterman score: 4178; 98.7% identity (99.5% similar) in 636 aa overlap (5-638:14-649)

                        10          20        30        40         
pF1KSD          MSLGQSACLFLS--IARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQ
                    ...: ::.  .::::::::::::::::::::::::::::::::::::
XP_016 MDSISNVDASLHHKNTCSFLGCGLARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQ
               10        20        30        40        50        60

      50        60        70        80        90       100         
pF1KSD RSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIP
               70        80        90       100       110       120

     110       120       130       140       150       160         
pF1KSD ASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLV
              130       140       150       160       170       180

     170       180       190       200       210       220         
pF1KSD PILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLK
              190       200       210       220       230       240

     230       240       250       260       270       280         
pF1KSD LYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLH
              250       260       270       280       290       300

     290       300       310       320       330       340         
pF1KSD EIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKS
              310       320       330       340       350       360

     350       360       370       380       390       400         
pF1KSD KDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDA
              370       380       390       400       410       420

     410       420       430       440       450       460         
pF1KSD FPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEA
              430       440       450       460       470       480

     470       480       490       500       510       520         
pF1KSD KAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNS
              490       500       510       520       530       540

     530       540       550       560       570       580         
pF1KSD ETGPGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETGPGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEEL
              550       560       570       580       590       600

     590       600       610       620       630        
pF1KSD EKEKKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKEKKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
              610       620       630       640         

>>XP_005264732 (OMIM: 610587) PREDICTED: rho GTPase-acti  (645 aa)
 initn: 4169 init1: 4169 opt: 4169  Z-score: 2600.2  bits: 491.3 E(85289): 4.3e-138
Smith-Waterman score: 4169; 100.0% identity (100.0% similar) in 626 aa overlap (13-638:20-645)

                      10        20        30        40        50   
pF1KSD        MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIV
                          :::::::::::::::::::::::::::::::::::::::::
XP_005 MSLKLPRNWDFNLKVEAAKIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIV
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KSD KNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWD
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KSD QNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILV
              130       140       150       160       170       180

           180       190       200       210       220       230   
pF1KSD EKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLR
              190       200       210       220       230       240

           240       250       260       270       280       290   
pF1KSD DLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQL
              250       260       270       280       290       300

           300       310       320       330       340       350   
pF1KSD NCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP
              310       320       330       340       350       360

           360       370       380       390       400       410   
pF1KSD LSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPED
              370       380       390       400       410       420

           420       430       440       450       460       470   
pF1KSD SSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGE
              430       440       450       460       470       480

           480       490       500       510       520       530   
pF1KSD GHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGP
              490       500       510       520       530       540

           540       550       560       570       580       590   
pF1KSD GKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEK
              550       560       570       580       590       600

           600       610       620       630        
pF1KSD KKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
              610       620       630       640     

>>XP_016860912 (OMIM: 610587) PREDICTED: rho GTPase-acti  (650 aa)
 initn: 4152 init1: 3226 opt: 4166  Z-score: 2598.3  bits: 491.0 E(85289): 5.5e-138
Smith-Waterman score: 4166; 98.6% identity (99.4% similar) in 637 aa overlap (5-638:14-650)

                        10          20        30        40         
pF1KSD          MSLGQSACLFLS--IARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQ
                    ...: ::.  .::::::::::::::::::::::::::::::::::::
XP_016 MDSISNVDASLHHKNTCSFLGCGLARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQ
               10        20        30        40        50        60

      50        60        70        80        90       100         
pF1KSD RSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIP
               70        80        90       100       110       120

     110       120       130       140        150       160        
pF1KSD ASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCG-VFGQRLDETVAYEQKFGPHL
       ::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_016 ASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHL
              130       140       150       160       170       180

      170       180       190       200       210       220        
pF1KSD VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLL
              190       200       210       220       230       240

      230       240       250       260       270       280        
pF1KSD KLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFL
              250       260       270       280       290       300

      290       300       310       320       330       340        
pF1KSD HEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPK
              310       320       330       340       350       360

      350       360       370       380       390       400        
pF1KSD SKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSD
              370       380       390       400       410       420

      410       420       430       440       450       460        
pF1KSD AFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSE
              430       440       450       460       470       480

      470       480       490       500       510       520        
pF1KSD AKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPN
              490       500       510       520       530       540

      530       540       550       560       570       580        
pF1KSD SETGPGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SETGPGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEE
              550       560       570       580       590       600

      590       600       610       620       630        
pF1KSD LEKEKKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKEKKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
              610       620       630       640       650

>>NP_001007232 (OMIM: 610587) rho GTPase-activating prot  (646 aa)
 initn: 4155 init1: 3226 opt: 4157  Z-score: 2592.7  bits: 490.0 E(85289): 1.1e-137
Smith-Waterman score: 4157; 99.8% identity (99.8% similar) in 627 aa overlap (13-638:20-646)

                      10        20        30        40        50   
pF1KSD        MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIV
                          :::::::::::::::::::::::::::::::::::::::::
NP_001 MSLKLPRNWDFNLKVEAAKIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIV
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KSD KNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWD
               70        80        90       100       110       120

           120       130       140        150       160       170  
pF1KSD QNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCG-VFGQRLDETVAYEQKFGPHLVPIL
       ::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 QNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHLVPIL
              130       140       150       160       170       180

            180       190       200       210       220       230  
pF1KSD VEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYL
              190       200       210       220       230       240

            240       250       260       270       280       290  
pF1KSD RDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQ
              250       260       270       280       290       300

            300       310       320       330       340       350  
pF1KSD LNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDI
              310       320       330       340       350       360

            360       370       380       390       400       410  
pF1KSD PLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPE
              370       380       390       400       410       420

            420       430       440       450       460       470  
pF1KSD DSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAG
              430       440       450       460       470       480

            480       490       500       510       520       530  
pF1KSD EGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETG
              490       500       510       520       530       540

            540       550       560       570       580       590  
pF1KSD PGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKE
              550       560       570       580       590       600

            600       610       620       630        
pF1KSD KKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
              610       620       630       640      

>>XP_011531509 (OMIM: 610587) PREDICTED: rho GTPase-acti  (620 aa)
 initn: 4116 init1: 3226 opt: 4118  Z-score: 2568.8  bits: 485.5 E(85289): 2.4e-136
Smith-Waterman score: 4118; 99.8% identity (99.8% similar) in 620 aa overlap (20-638:1-620)

               10        20        30        40        50        60
pF1KSD MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
                          :::::::::::::::::::::::::::::::::::::::::
XP_011                    MTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
                                  10        20        30        40 

               70        80        90       100       110       120
pF1KSD FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
              50        60        70        80        90       100 

              130       140        150       160       170         
pF1KSD SYVLMASSQAEMEEWVKFLRRVAGTPCG-VFGQRLDETVAYEQKFGPHLVPILVEKCAEF
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 SYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHLVPILVEKCAEF
             110       120       130       140       150       160 

     180       190       200       210       220       230         
pF1KSD ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
             170       180       190       200       210       220 

     240       250       260       270       280       290         
pF1KSD VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
             230       240       250       260       270       280 

     300       310       320       330       340       350         
pF1KSD MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
             290       300       310       320       330       340 

     360       370       380       390       400       410         
pF1KSD KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
             350       360       370       380       390       400 

     420       430       440       450       460       470         
pF1KSD EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
             410       420       430       440       450       460 

     480       490       500       510       520       530         
pF1KSD SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
             470       480       490       500       510       520 

     540       550       560       570       580       590         
pF1KSD EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
             530       540       550       560       570       580 

     600       610       620       630        
pF1KSD EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::
XP_011 EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
             590       600       610       620

>>XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase-acti  (620 aa)
 initn: 4116 init1: 3226 opt: 4118  Z-score: 2568.8  bits: 485.5 E(85289): 2.4e-136
Smith-Waterman score: 4118; 99.8% identity (99.8% similar) in 620 aa overlap (20-638:1-620)

               10        20        30        40        50        60
pF1KSD MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
                          :::::::::::::::::::::::::::::::::::::::::
XP_011                    MTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
                                  10        20        30        40 

               70        80        90       100       110       120
pF1KSD FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
              50        60        70        80        90       100 

              130       140        150       160       170         
pF1KSD SYVLMASSQAEMEEWVKFLRRVAGTPCG-VFGQRLDETVAYEQKFGPHLVPILVEKCAEF
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 SYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHLVPILVEKCAEF
             110       120       130       140       150       160 

     180       190       200       210       220       230         
pF1KSD ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
             170       180       190       200       210       220 

     240       250       260       270       280       290         
pF1KSD VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
             230       240       250       260       270       280 

     300       310       320       330       340       350         
pF1KSD MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
             290       300       310       320       330       340 

     360       370       380       390       400       410         
pF1KSD KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
             350       360       370       380       390       400 

     420       430       440       450       460       470         
pF1KSD EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
             410       420       430       440       450       460 

     480       490       500       510       520       530         
pF1KSD SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
             470       480       490       500       510       520 

     540       550       560       570       580       590         
pF1KSD EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
             530       540       550       560       570       580 

     600       610       620       630        
pF1KSD EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::
XP_011 EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
             590       600       610       620

>>XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase-acti  (620 aa)
 initn: 4116 init1: 3226 opt: 4118  Z-score: 2568.8  bits: 485.5 E(85289): 2.4e-136
Smith-Waterman score: 4118; 99.8% identity (99.8% similar) in 620 aa overlap (20-638:1-620)

               10        20        30        40        50        60
pF1KSD MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
                          :::::::::::::::::::::::::::::::::::::::::
XP_011                    MTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
                                  10        20        30        40 

               70        80        90       100       110       120
pF1KSD FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
              50        60        70        80        90       100 

              130       140        150       160       170         
pF1KSD SYVLMASSQAEMEEWVKFLRRVAGTPCG-VFGQRLDETVAYEQKFGPHLVPILVEKCAEF
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 SYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHLVPILVEKCAEF
             110       120       130       140       150       160 

     180       190       200       210       220       230         
pF1KSD ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPV
             170       180       190       200       210       220 

     240       250       260       270       280       290         
pF1KSD VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNK
             230       240       250       260       270       280 

     300       310       320       330       340       350         
pF1KSD MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQ
             290       300       310       320       330       340 

     360       370       380       390       400       410         
pF1KSD KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPR
             350       360       370       380       390       400 

     420       430       440       450       460       470         
pF1KSD EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTM
             410       420       430       440       450       460 

     480       490       500       510       520       530         
pF1KSD SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG
             470       480       490       500       510       520 

     540       550       560       570       580       590         
pF1KSD EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAAL
             530       540       550       560       570       580 

     600       610       620       630        
pF1KSD EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::
XP_011 EISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
             590       600       610       620

>>XP_005264733 (OMIM: 610587) PREDICTED: rho GTPase-acti  (607 aa)
 initn: 3226 init1: 3226 opt: 3230  Z-score: 2019.2  bits: 383.8 E(85289): 9.9e-106
Smith-Waterman score: 3815; 93.9% identity (93.9% similar) in 626 aa overlap (13-638:20-607)

                      10        20        30        40        50   
pF1KSD        MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIV
                          :::::::::::::::::::::::::::::::::::::::::
XP_005 MSLKLPRNWDFNLKVEAAKIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIV
               10        20        30        40        50        60

            60        70        80        90       100       110   
pF1KSD KNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWD
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::   
XP_005 KNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPA---
               70        80        90       100       110          

           120       130       140       150       160       170   
pF1KSD QNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILV
                                          :::::::::::::::::::::::::
XP_005 -----------------------------------VFGQRLDETVAYEQKFGPHLVPILV
                                          120       130       140  

           180       190       200       210       220       230   
pF1KSD EKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLR
            150       160       170       180       190       200  

           240       250       260       270       280       290   
pF1KSD DLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQL
            210       220       230       240       250       260  

           300       310       320       330       340       350   
pF1KSD NCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP
            270       280       290       300       310       320  

           360       370       380       390       400       410   
pF1KSD LSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPED
            330       340       350       360       370       380  

           420       430       440       450       460       470   
pF1KSD SSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGE
            390       400       410       420       430       440  

           480       490       500       510       520       530   
pF1KSD GHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGP
            450       460       470       480       490       500  

           540       550       560       570       580       590   
pF1KSD GKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEK
            510       520       530       540       550       560  

           600       610       620       630        
pF1KSD KKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
       :::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
            570       580       590       600       




638 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 23:39:26 2016 done: Wed Nov  2 23:39:27 2016
 Total Scan time:  9.550 Total Display time:  0.140

Function used was FASTA [36.3.4 Apr, 2011]
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