染色体工学研究室
論 文 リ ス ト
2020
- An Artificial Conversion of Roots into Organs with Shoot Stem Characteristics by Inducing Two Transcription Factors.
- Hanano S, Tomatsu H, Ohnishi A, Kobayashi K, Kondo Y, Betsuyaku S, Takita E, Ogata Y, Ozawa K, Suda K, Hosouchi T, Nagase T, Suzuki H, Sakurai N, Masumoto H, Fukuda H, Shibata D.
- iScience. 23(7): 101332. (2020)
- H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory..
- Martins NMC, Cisneros-Soberanis F, Pesenti E, Kochanova NY, Shang WH, Hori T, Nagase T, Kimura H, Larionov V, Masumoto H, Fukagawa T, Earnshaw WC.
- J Cell Sci. 133(14): jcs242610. (2020)
- CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly.
- Otake K, Ohzeki JI, Shono N, Kugou K, Okazaki K, Nagase T, Yamakawa H, Kouprina N, Larionov V, Kimura H, Earnshaw WC, Masumoto H.
- J Cell Sci. 133(15): jcs243303. (2020)
- Analysis of Complex DNA Rearrangements during Early Stages of HAC Formation.
- Pesenti E, Liskovykh M, Okazaki K, Mallozzi A, Reid C, Abad MA, Jeyaprakash AA, Kouprina N, Larionov V, Masumoto H, Earnshaw WC.
- ACS Synth Biol. 9(12): 3267-3287. (2020)
- Human artificial chromosome: Chromatin assembly mechanisms and CENP-B.
- Ohzeki J, Otake K, Masumoto H.
- Exp. Cell Res. 389(2), 111900. (2020) Review
- Artificial chromosomes.
- Fachinetti D, Masumoto H, Kouprina N.
- Exp Cell Res. 396(1): 112302. Editorial. (2020) Review
- 染色体の安定性制御と創薬スクリーニング
- 大関淳一郎、Vladimir Larionov、舛本寛
- 細胞 52(8): 412-415. (2020)
2019
- De novo formation and epigenetic maintenance of centromere chromatin.
- Ohzeki J, Larionov V, Earnshaw WC, Masumoto H.
- Curr Opin Cell Biol. 58: 15-25. (2019)
- Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant α‐amyrin‐producing activity.
- Srisawat P, Fukushima EO, Yasumoto S, Robertlee J, Suzuki H, Seki H, Muranaka T.
- New Phytol. 224(1): 352-366. (2019)
- A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission.
- Liskovykh M, Goncharov NV, Petrov N, Aksenova V, Pegoraro G, Ozbun LL, Reinhold WC, Varma S, Dasso M, Kumeiko V, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
- Genome Res. 29(10): 1719-1732. (2019)
2018
- Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.
- Ito T, Okazaki K, Nakajima D, Shibata D, Murakami S, Schaffer S.
- Amino Acids 50(1): 117-124. (2018)
- The conserved histone variant H2A.Z illuminates meiotic recombination initiation.
- Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T.
- Current Genetics 64(5): 1015-1019. (2018)
- Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.
- Pesenti E, Kouprina N, Liskovykh M, Aurich-Costa J, Larionov V, Masumoto H, Earnshaw WC, Molina O.
- ACS Synthetic Biology 7(4): 1116-1130. (2018)
- Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.
- Kouprina N, Petrov N, Molina O, Liskovykh M, Pesenti E, Ohzeki J, Masumoto H, Earnshaw WC, Larionov V.
- ACS Synthetic Biology 7(9): 1974–1989. (2018)
- Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.
- Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.
- Cancer Research 78(21): 6282-6296. (2018)
2017
- The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast.
- Yamada, S., Kugou, K., Ding, D. Q., Fujita, Y., Hiraoka, Y., Murakami, H., Ohta, K. and Yamada, T. 2017
- Nucleic Acids Res., doi: 10.1093/nar/gkx1110.
- Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis.
- Tashiro, S., Nishihara, Y., Kugou, K., Ohta, K. and Kanoh, J. 2017
- Nucleic Acids Res., 45, 10333-10349.
- Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.
- Ito, T., Okazaki, K., Nakajima, D., Shibata, D., Murakami, S. and Schaffer, S. 2017
- Amino Acids, doi: 10.1007/s00726-017-2498-y.
- Method to assemble genomic DNA fragments or genes on human artificial chromosome with regulated kinetochore using a multi-integrase system.
- Lee, N. C. O., Kim, J. H., Petrov, N. S., Lee, H. S., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2017
- ACS Synth Biol., doi: 10.1021/acssynbio.7b00209.
- Using human artificial chromosomes to study centromere assembly and function.
- Molina, O., Kouprina, N., Masumoto, H., Larionov, V. and Earnshaw, W. C. 2017
- Chromosoma., 126, 559-575.
- CENP-Bによるセントロメアのエピジェネティクス制御への関わり CENP-B and centromere chromatin.
- 久郷和人、大竹興一郎、舛本 寛 2017
- Medical Science Digest, Vol. 43. ニューサイエンス社, pp. 629-632.
- 人工染色体を用いたセントロメア機能獲得のエピゲノム制御解析 Analyses for epigenetic controls of functional centromere acquisition using human artificial chromosomes.
- 大関淳一郎、舛本 寛 2017
- バイオサイエンスとインダストリー (B&I), Vol. 75. バイオインダストリー協会, pp. 304-309.
2016
- Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
- Tashiro, S., Handa, T., Matsuda, A., Ban, T., Takigawa, T., Miyasato, K., Ishii, K., Kugou, K., Ohta, K., Hiraoka, Y., Masukata, H. and Kanoh, J. 2016
- Nat Commun., 7, 10393.
- Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae.
- Mitsumori, R., Ohashi, T., Kugou, K., Ichino, A., Taniguchi, K., Ohta, K., Uchida, H. and Oki, M. 2016
- J Biochem., 160, 11-17.
- Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.
- Kim, J. H., Lee, H. S., Lee, N. C., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. and Larionov, V. 2016
- Oncotarget., 7, 14841-14856.
- CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.
- Suntronpong, A., Kugou, K., Masumoto, H., Srikulnath, K., Ohshima, K., Hirai, H. and Koga, A. 2016
- Biol. Lett., 12, 20150817.
- KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation.
- Ohzeki, J., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2016
- Dev Cell., 37, 413-427.
- Formation of functional CENP-B boxes at diverse locations in repeat units of centromeric DNA in New World monkeys.
- Kugou, K., Hirai, H., Masumoto, H. and Koga, A. 2016
- Sci Rep., 6, 27833.
- 3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin.
- Booth, D. G., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A. and Earnshaw, W. C. 2016
- Mol Cell, 64, 790-802.
- Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.
- Molina, O., Vargiu, G., Abad, M. A., Zhiteneva, A., Jeyaprakash, A. A., Masumoto, H., Kouprina, N., Larionov, V. and Earnshaw, W. C. 2016
- Nat Commun., 7, 13334.
2015
- CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
- Shono, N., Ohzeki, J., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2015
- J. Cell Science, 128, 4572-4587.
- Stable complex formation of CENP-B with the CENP-A nucleosome.
- Fujita, R., Otake, K., Arimura, Y., Horikoshi, N., Miya, Y., Shiga, T., Osakabe, A., Tachiwana, H., Ohzeki, J., Larionov, V., Masumoto, H. and Kurumizaka, H. 2015
- Nucleic Acids Res., 43, 4909-4922.
- Genetic and epigenetic regulation of centromeres: A look at HAC formation.
- Ohzeki, J., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2015
- Chromosome Res., 23, 87-103.
- Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.
- Kononenko, A. V., Lee, N. C., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2015
- Nucleic Acids Res., 43, e57.
- Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs.
- Hasegawa, Y., Ishikura, T., Hasegawa, T., Watanabe, T., Suzuki, J., Nakayama, M., Okamura, Y., Okazaki, T., Koseki, H., Ohara, O., Ikeno, M. and Masumoto, H. 2015
- Chromosoma, 124, 107-118.
- Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome.
- Erliandri, I., Fu, H., Nakano, M., Kim, J. H., Miga, K. H., Liskovykh, M., Earnshaw, W. C., Masumoto, H., Kouprina, N., Aladjem, M. I. and Larionov, V. 2015
- Nucleic Acids Res., 42, 11502-11516.
2014 以前
- A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.
- Kononenko, A. V., Bansal, R., Lee, N. C., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2014
- Nucleic Acids Res., 42, e164.
- The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
- Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarashi, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H., Koseki, H. and Hase, K. 2014
- Nat Immunol., 15, 571-579.
- Human artificial chromosome based gene delivery vectors for biomedicine and biotechnology.
- Kouprina, N., Tomilin, A. N., Masumoto, H., Earnshaw, W. C. and Larionov, V. 2014
- Expert Opin. Drug Deliv., 11, 517-35.
- Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA
- Dai, X., Otake, K., You, C., Cai, Q., Wang, Z., Masumoto, H. and Wang, Y. 2013
- J Proteome Res., 12, 4167-4175.
- A new generation of human artificial chromosomes for functional genomics and gene therapy.
- Kouprina, N., Earnshaw, W. C., Masumoto, H. and Larionov, V. 2013
- Cell Mol Life Sci., 70, 1135-1148.
- A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells.
- Lee, H. S., Lee, N. C., Grimes, B. R., Samoshkin, A., Kononenko, A. V., Bansal, R., Masumoto, H., Earnshaw, W. C., Kouprina, N. and Larionov, V. 2013
- BMC Cancer, 13, 252.
- Protecting a transgene expression from the HAC-based vector by different chromatin insulators.
- Lee, N. C., Kononenko, A. V., Lee, H. S., Tolkunova, E. N., Liskovykh, M. A., Masumoto, H., Earnshaw, W. C., Tomilin, A. N., Larionov, V. and Kouprina, N. 2013
- Cell Mol Life Sci., 70, 3723-3737.
- Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
- Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H., Copenhaver, G. P., Deluca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J., Harrison, S. C., Heun, P., Hirota, T., Jansen, L. E., Karpen, G., Kops, G. J., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D, Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K. and Cleveland, D. W. 2013
- Chromosome Res., 21, 101-106.
- Nap1 regulates proper CENP-B binding to nucleosomes.
- Tachiwana, H., Miya, Y., Shono, N., Ohzeki, J., Osakabe, A., Otake, K., Larionov, V., Earnshaw, W. C., Kimura, H., Masumoto, H. and Kurumizaka, H. 2013
- Nucleic Acids Res., 41, 2869-2880.
- Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly.
- Ohzeki, J., Bergmann, J. H., Kouprina, N., Noskov, V. N., Nakano, M., Kimura, H., Earnshaw, W. C., Larionov, V., Masumoto, H. 2012
- EMBO J., 31, 2391-2402.
- Inactivation of a human kinetochore by specific targeting of chromatin modifiers.
- Nakano, M., Cardinale, S., Noskov, V., Gassmann, R., Vagnarelli, P., Kandels-Lewis, S., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2008
- Developmental Cell, 14, 507-522.
- CENP-B controls centromere formation depending on the chromatin context.
- Okada, T., Ohzeki, J., Nakano, M., Yoda, K., Brinkley, W. R., Larionov, V. and Masumoto, H. 2007
- Cell, 131, 1287-1300.
- A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere.
- Okamoto, Y., Nakano, M., Ohzeki, J., Larionov, V. and Masumoto, H. 2007
- EMBO J., 26, 1279-1291.
- Construction of YAC based Mammalian Artificial Chromosomes.
- Ikeno, M., Grimes, B., Okazaki T., Nakano, M., Saitoh, K., Hoshino, H., McGill, N., Cooke, H. and Masumoto H.1998
- Nature Biotech., 16, 431-439.