# /usr/local/bin/fasta34 -b50 -d10 -E0.01 -H -O./tmp/hh10131mrp1.fasta.huge -Q ../query/KIAA1643.ptfa ./tmplib.25089 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1643, 993 aa vs ./tmplib.25089 library 1986512 residues in 2037 sequences Expectation_n fit: rho(ln(x))= 7.9520+/-0.00805; mu= 5.3221+/- 0.546 mean_var=248.6246+/-59.201, 0's: 0 Z-trim: 10 B-trim: 4 in 1/39 Lambda= 0.081340 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 39, opt: 27, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2037) KIAA0371 ( 1203 res) hh00252 (1203) 273 45.8 3.9e-05 KIAA1362 ( 699 res) fj02381 ( 699) 264 44.5 5.8e-05 KIAA1537 ( 619 res) fj02581s1 ( 619) 242 41.8 0.00032 KIAA1589 ( 816 res) fj08951 ( 816) 234 41.0 0.00073 KIAA0993 ( 1556 res) bf03014 (1556) 238 41.8 0.0008 KIAA0647 ( 1195 res) hj03819s1 (1195) 232 41.0 0.0011 KIAA1255 ( 1232 res) hh14633s1 (1232) 228 40.5 0.0016 KIAA0305 ( 1547 res) hg00042 (1547) 223 40.1 0.0027 KIAA0321 ( 1542 res) hg00426 (1542) 219 39.6 0.0037 >>KIAA0371 ( 1203 res) hh00252 (1203 aa) initn: 375 init1: 249 opt: 273 Z-score: 184.0 bits: 45.8 E(): 3.9e-05 Smith-Waterman score: 344; 24.420% identity (49.304% similar) in 647 aa overlap (390-979:572-1180) 360 370 380 390 400 410 KIAA16 SELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAP ::: . . : .: :. .:. .. KIAA03 WSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPC------PSPTTPVDDSC 550 560 570 580 590 420 430 440 450 460 470 KIAA16 LPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRP : .: .. : ..: . .::. . : :. . : .: . . :: KIAA03 APYPAPGTSPDDPPLSRLPKTRSYDNLTTA-CDNTVPLASRRCS---DPSLNEKWQEHRR 600 610 620 630 640 650 480 490 500 510 520 530 KIAA16 GAEGSPGGEASPGRPRLRSGS-DEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWAD . : : . :.::. : . : . :: : :: . : . . : KIAA03 SLELS--SLAGPGEDPLSADSLGKPTRV------PGGAELSVAAGVAEGQMENILQE-AT 660 670 680 690 700 540 550 560 570 580 590 KIAA16 PQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEG---TDGASLAGTSSCSCLDS---RL .:.: :. ::: . . ::. : :: :. : :: : . : . : KIAA03 KEESGVEEPAHRAGIEIQEG-KEDPL----LEKESRRKTPEASAIGLHQDPELGDAALRS 710 720 730 740 750 600 610 620 630 640 650 KIAA16 HLD-GWEVGADDAETAEMIAHRTGGMK-LSATVIFNPKSPTSLDSAVATQEAASEPVAEG ::: .: . .. :... .:.. : ... :.. ::. : ... : .::: KIAA03 HLDMSWPL------FSQGISEQQSGLSVLLSSLQVPPRGEDSLE--VPVEQFRIEEIAEG 760 770 780 790 800 660 670 680 690 KIAA16 MDGG--P----HKLSTGAT-NC-LLHSCVCCGSCG---DSREDVVERLREKCSPGGVIGA . . : :.. :.. .: :: : : . : :: :.. . . : : .: : KIAA03 REEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVK-SVSGPQGH 810 820 830 840 850 860 700 710 720 730 740 KIAA16 SYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAP--------------TSDKC-LPHT . . ...:: :. .: : ::: . : :.. : . : :: . KIAA03 HRSCLVNSGKDRLPQTME--PSPSETSLVER-PQVGSVVHRTSLGSTLSLTRSPCALPLA 870 880 890 900 910 920 750 760 770 780 790 KIAA16 SGSQVDTASGLQGEAGVAGQQEPEARELHAGSPPAHEAPQALSGSSSST------AGSCS .. . .: . :..: : :. : . .. .: :... : ::: KIAA03 ECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCS 930 940 950 960 970 980 800 810 820 830 840 KIAA16 SDKMGPE-----------AAPAATHAAPQATREKIRSRFHGSH-DLIH-RLFVCISGVAD : .. . . :.:: . : .: .. . . . : :. :: :: . KIAA03 SAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQ 990 1000 1010 1020 1030 1040 850 860 870 880 890 900 KIAA16 QLQT--NYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDC-ALCQETLSS ...: . ...:.: :.. . . . . . : ... .. .. .: ..: . :. . : KIAA03 EVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDS-ESNLDQNCLSRCSTEIFS 1050 1060 1070 1080 1090 1100 910 920 930 940 950 960 KIAA16 SELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAP : . . : . . .:.::. . : :: . : . ::::::.::..::: : ....: KIAA03 -EASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVP 1110 1120 1130 1140 1150 1160 970 980 990 KIAA16 LPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL .: .: ::: :: KIAA03 VPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN 1170 1180 1190 1200 >>KIAA1362 ( 699 res) fj02381 (699 aa) initn: 238 init1: 163 opt: 264 Z-score: 181.0 bits: 44.5 E(): 5.8e-05 Smith-Waterman score: 264; 28.205% identity (58.974% similar) in 156 aa overlap (828-979:457-609) 800 810 820 830 840 850 KIAA16 SSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLR- : . : . : . : : : ..:. KIAA13 ILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKI 430 440 450 460 470 480 860 870 880 890 900 910 KIAA16 -SILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALC-QETLSSSELAAKTRDGDF :. ... ..... :. : :. ...... : . ..: ...:. .. : . . . KIAA13 ESVERSF--ILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPL 490 500 510 520 530 540 920 930 940 950 960 970 KIAA16 -EDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVR : :.:: .: : . ::. :.::::.:::: :. :::.. : : . .:.: KIAA13 GSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLD-YLKNQPAR 550 560 570 580 590 600 980 990 KIAA16 VCTHCYMFHVTPFYSDKAGL :: ::. KIAA13 VCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANT 610 620 630 640 650 660 >>KIAA1537 ( 619 res) fj02581s1 (619 aa) initn: 227 init1: 175 opt: 242 Z-score: 167.7 bits: 41.8 E(): 0.00032 Smith-Waterman score: 242; 30.345% identity (57.241% similar) in 145 aa overlap (846-983:477-611) 820 830 840 850 860 870 KIAA16 QATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPE---- : . . : ::. . .... : : KIAA15 QISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQ---QIISLKKEFLNL 450 460 470 480 490 500 880 890 900 910 920 KIAA16 TDDKEKLRKVTQTLRSAALE-DCALCQETLSSSEL--AAKTRDGDFEDPPEWVPDEACGF :....:.:. . ..: : : . :. .. : :. .: :. :. KIAA15 QDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLV-----WLKDKEATH 510 520 530 540 550 930 940 950 960 970 980 KIAA16 CTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYS : :. :.. .::::::.::.:::. ::.. ::: .. :::::: :. . . KIAA15 CKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLP--SSPKPVRVCDSCHALLIQRCSS 560 570 580 590 600 610 990 KIAA16 DKAGL KIAA15 NLP >>KIAA1589 ( 816 res) fj08951 (816 aa) initn: 375 init1: 224 opt: 234 Z-score: 161.2 bits: 41.0 E(): 0.00073 Smith-Waterman score: 234; 38.824% identity (56.471% similar) in 85 aa overlap (897-978:725-809) 870 880 890 900 910 920 KIAA16 ATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFED---PPEWVPD :.::.. : : .: : :::: KIAA15 EARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPD 700 710 720 730 740 750 930 940 950 960 970 980 KIAA16 EACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHV . : :. :.. :::::.::. ::..:: .: : .::::: .: KIAA15 HEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPG 760 770 780 790 800 810 990 KIAA16 TPFYSDKAGL KIAA15 DL >>KIAA0993 ( 1556 res) bf03014 (1556 aa) initn: 271 init1: 238 opt: 238 Z-score: 160.5 bits: 41.8 E(): 0.0008 Smith-Waterman score: 238; 43.333% identity (75.000% similar) in 60 aa overlap (920-979:1481-1540) 890 900 910 920 930 940 KIAA16 LEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCG :: ::. :..:.. :.. .:.::::.:: KIAA09 DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG 1460 1470 1480 1490 1500 1510 950 960 970 980 990 KIAA16 KIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL ..::..:: .. . : .::::: .:: KIAA09 QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC 1520 1530 1540 1550 >>KIAA0647 ( 1195 res) hj03819s1 (1195 aa) initn: 283 init1: 230 opt: 232 Z-score: 158.0 bits: 41.0 E(): 0.0011 Smith-Waterman score: 232; 33.333% identity (52.381% similar) in 105 aa overlap (875-979:1074-1170) 850 860 870 880 890 900 KIAA16 DQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSE ::. . :. . : ::: :: KIAA06 RELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCL--------SE 1050 1060 1070 1080 1090 910 920 930 940 950 960 KIAA16 LAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLP . . : . .::::. . : : : . .:.::::.::..::. : . :.: KIAA06 ASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIP 1100 1110 1120 1130 1140 1150 970 980 990 KIAA16 RYGQVKPVRVCTHCYMFHVTPFYSDKAGL :: ::. :: KIAA06 DQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS 1160 1170 1180 1190 >>KIAA1255 ( 1232 res) hh14633s1 (1232 aa) initn: 237 init1: 181 opt: 228 Z-score: 155.3 bits: 40.5 E(): 0.0016 Smith-Waterman score: 228; 36.250% identity (62.500% similar) in 80 aa overlap (900-979:1148-1223) 870 880 890 900 910 920 KIAA16 PETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFC .....: . : ..:: : ..: KIAA12 GNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPP-WCDG---SYC 1120 1130 1140 1150 1160 1170 930 940 950 960 970 980 KIAA16 TACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSD : : : : :::::: ::...: .::.. :. .. ::::::. :. KIAA12 YECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1180 1190 1200 1210 1220 1230 990 KIAA16 KAGL >>KIAA0305 ( 1547 res) hg00042 (1547 aa) initn: 217 init1: 184 opt: 223 Z-score: 151.0 bits: 40.1 E(): 0.0027 Smith-Waterman score: 223; 45.161% identity (67.742% similar) in 62 aa overlap (918-979:750-809) 890 900 910 920 930 940 KIAA16 AALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRS : :::: : :.. :: .:.::::. KIAA03 SEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRA 720 730 740 750 760 770 950 960 970 980 990 KIAA16 CGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL :::.::. : ... : .: . : .:::. :: KIAA03 CGKVFCGVCCNRKCKL-QYLE-KEARVCVVCYETISKAQAFERMMSPTGSNLKSNHSDEC 780 790 800 810 820 830 KIAA03 TTVQPPQENQTSSIPSPATLPVSALKQPGVEGLCSKEQKRVWFADGILPNGEVADTTKLS 840 850 860 870 880 890 >>KIAA0321 ( 1542 res) hg00426 (1542 aa) initn: 263 init1: 124 opt: 219 Z-score: 148.5 bits: 39.6 E(): 0.0037 Smith-Waterman score: 219; 40.580% identity (71.014% similar) in 69 aa overlap (917-981:806-873) 890 900 910 920 930 940 KIAA16 SAALEDCALCQETLSSSELAAKTRDGDFEDPP---EWVPDEACGFCTAC-KAPFTVIRRK :: .:::::. ..: .: . ::.. :. KIAA03 PGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRR 780 790 800 810 820 830 950 960 970 980 990 KIAA16 HHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL :::: ::.. :: ::... . . . .:.::: .:: . KIAA03 HHCRRCGRLVCSSCSTKKM-VVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKS 840 850 860 870 880 890 KIAA03 ESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACG 900 910 920 930 940 950 993 residues in 1 query sequences 1986512 residues in 2037 library sequences Scomplib [34.26] start: Thu Dec 18 15:11:28 2008 done: Thu Dec 18 15:11:29 2008 Total Scan time: 0.670 Total Display time: 0.230 Function used was FASTA [version 34.26.5 April 26, 2007]