# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fh21445.fasta.nr -Q ../query/KIAA1566.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1566, 1313 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7824373 sequences Expectation_n fit: rho(ln(x))= 6.1452+/-0.000191; mu= 10.5889+/- 0.011 mean_var=99.5328+/-19.385, 0's: 39 Z-trim: 54 B-trim: 392 in 2/62 Lambda= 0.128556 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 40, opt: 28, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|41688792|sp|Q9BYP7.2|WNK3_HUMAN RecName: Full=S (1743) 8559 1598.9 0 gi|114688769|ref|XP_001146822.1| PREDICTED: WNK ly (1743) 8514 1590.6 0 gi|109130874|ref|XP_001089789.1| PREDICTED: WNK ly (1740) 8290 1549.0 0 gi|149758014|ref|XP_001495798.1| PREDICTED: simila (1745) 7590 1419.2 0 gi|74007027|ref|XP_864627.1| PREDICTED: similar to (1748) 7268 1359.5 0 gi|74007023|ref|XP_864589.1| PREDICTED: similar to (1786) 7268 1359.5 0 gi|57209549|emb|CAI40707.1| WNK lysine deficient p (1790) 5335 1001.0 0 gi|19908348|gb|AAL99253.1| putative protein kinase (1800) 5335 1001.0 0 gi|40738019|gb|AAR89465.1| putative protein kinase (1800) 5335 1001.0 0 gi|114688771|ref|XP_521078.2| PREDICTED: WNK lysin (1800) 5311 996.5 0 gi|109130872|ref|XP_001089672.1| PREDICTED: WNK ly (1797) 5161 968.7 0 gi|74007029|ref|XP_864644.1| PREDICTED: similar to (1795) 4616 867.6 0 gi|74007025|ref|XP_549020.2| PREDICTED: similar to (1805) 4616 867.6 0 gi|194045108|ref|XP_001926671.1| PREDICTED: simila (1145) 4314 811.5 0 gi|94408423|ref|XP_914679.2| PREDICTED: similar to (1790) 4141 779.5 0 gi|126253824|sp|Q80XP9.2|WNK3_MOUSE RecName: Full= (1789) 4136 778.6 0 gi|149031320|gb|EDL86318.1| rCG38922 [Rattus norve (1691) 2293 436.8 5.8e-119 gi|27695440|gb|AAH43119.1| Wnk3 protein [Mus muscu ( 462) 2167 413.0 2.3e-112 gi|148675544|gb|EDL07491.1| mCG53652 [Mus musculus (1705) 2070 395.4 1.6e-106 gi|149272327|ref|XP_001481348.1| PREDICTED: simila (1798) 1859 356.3 1e-94 gi|119923285|ref|XP_612806.3| PREDICTED: similar t ( 700) 1538 296.5 4.1e-77 gi|149049592|gb|EDM02046.1| protein kinase, lysine (2085) 700 141.4 6e-30 gi|148667212|gb|EDK99628.1| WNK lysine deficient p (2086) 690 139.5 2.2e-29 gi|74184785|dbj|BAE27991.1| unnamed protein produc (2065) 653 132.6 2.5e-27 gi|194224969|ref|XP_001917974.1| PREDICTED: simila (2060) 603 123.4 1.5e-24 gi|126336546|ref|XP_001379127.1| PREDICTED: hypoth (2243) 581 119.3 2.8e-23 gi|194669647|ref|XP_582977.4| PREDICTED: WNK lysin (2280) 570 117.3 1.2e-22 gi|109112348|ref|XP_001108626.1| PREDICTED: simila (2142) 561 115.6 3.5e-22 gi|119583261|gb|EAW62857.1| WNK lysine deficient p (2296) 554 114.3 9.1e-22 gi|41688799|sp|Q9Y3S1.4|WNK2_HUMAN RecName: Full=S (2297) 554 114.3 9.1e-22 gi|28386091|gb|AAH46464.1| Wnk2 protein [Mus muscu (1557) 542 112.0 3.1e-21 gi|189536379|ref|XP_001921648.1| PREDICTED: hypoth (2977) 544 112.5 4e-21 gi|37994554|gb|AAH60187.1| Wnk2 protein [Mus muscu (1349) 538 111.2 4.7e-21 gi|119583262|gb|EAW62858.1| WNK lysine deficient p (2216) 541 111.9 4.7e-21 gi|157057176|ref|NP_083637.2| WNK lysine deficient (2059) 538 111.3 6.5e-21 gi|150044395|emb|CAO03351.1| WNK lysine deficient (1772) 537 111.1 6.6e-21 gi|126253823|sp|Q3UH66.2|WNK2_MOUSE RecName: Full= (2149) 538 111.3 6.8e-21 gi|208965700|dbj|BAG72864.1| WNK lysine deficient (2210) 537 111.2 7.9e-21 gi|119583264|gb|EAW62860.1| WNK lysine deficient p (2210) 537 111.2 7.9e-21 gi|119583263|gb|EAW62859.1| WNK lysine deficient p (2217) 537 111.2 7.9e-21 gi|32455273|ref|NP_006639.3| WNK lysine deficient (2217) 537 111.2 7.9e-21 gi|189536026|ref|XP_695795.3| PREDICTED: im:715275 (2980) 536 111.1 1.1e-20 gi|109504743|ref|XP_225204.4| PREDICTED: similar t (2364) 532 110.2 1.6e-20 gi|148726102|emb|CAN88670.1| novel protein [Danio (1088) 515 106.9 7.6e-20 gi|47203572|emb|CAG13577.1| unnamed protein produc ( 103) 484 100.4 6.3e-19 gi|149412695|ref|XP_001508024.1| PREDICTED: simila (2425) 498 104.0 1.3e-18 gi|11527775|dbj|BAB18648.1| mitogen-activated prot ( 779) 488 101.8 1.9e-18 gi|150175959|emb|CAO03646.1| WNK lysine deficient ( 790) 488 101.8 1.9e-18 gi|189537421|ref|XP_683307.3| PREDICTED: similar t (1629) 461 97.0 1.1e-16 gi|118083044|ref|XP_001235131.1| PREDICTED: simila (2380) 445 94.1 1.1e-15 >>gi|41688792|sp|Q9BYP7.2|WNK3_HUMAN RecName: Full=Serin (1743 aa) initn: 8559 init1: 8559 opt: 8559 Z-score: 8572.5 bits: 1598.9 E(): 0 Smith-Waterman score: 8559; 99.924% identity (99.924% similar) in 1311 aa overlap (3-1313:433-1743) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|416 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|416 SKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 830 840 850 860 870 KIAA15 HLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 HLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAK 1250 1260 1270 1280 1290 1300 880 890 900 910 920 930 KIAA15 MTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 MTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKEN 1310 1320 1330 1340 1350 1360 940 950 960 970 980 990 KIAA15 KGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 KGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQP 1370 1380 1390 1400 1410 1420 1000 1010 1020 1030 1040 1050 KIAA15 SSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 SSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIE 1430 1440 1450 1460 1470 1480 1060 1070 1080 1090 1100 1110 KIAA15 DEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 DEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRP 1490 1500 1510 1520 1530 1540 1120 1130 1140 1150 1160 1170 KIAA15 RSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 RSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTK 1550 1560 1570 1580 1590 1600 1180 1190 1200 1210 1220 1230 KIAA15 EAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 EAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLP 1610 1620 1630 1640 1650 1660 1240 1250 1260 1270 1280 1290 KIAA15 QGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|416 QGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGM 1670 1680 1690 1700 1710 1720 1300 1310 KIAA15 NMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::: gi|416 NMQAFPTSSVQNPATIPPGPK 1730 1740 >>gi|114688769|ref|XP_001146822.1| PREDICTED: WNK lysine (1743 aa) initn: 8514 init1: 8514 opt: 8514 Z-score: 8527.4 bits: 1590.6 E(): 0 Smith-Waterman score: 8514; 99.313% identity (99.771% similar) in 1311 aa overlap (3-1313:433-1743) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|114 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: gi|114 NTTLPLAPAQQSGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL ::::::::::::::::::::::::::::::::::::::::::::::::::. :::::::: gi|114 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKQPKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|114 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGVEQQAALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QEHSISNIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|114 SKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 830 840 850 860 870 KIAA15 HLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 HLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAK 1250 1260 1270 1280 1290 1300 880 890 900 910 920 930 KIAA15 MTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKEN ::::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::: gi|114 MTSFGIEHISVFSETNHSSEEAFIETAKSQLVEIEPATQNPKTSFSSEKLQALQETCKEN 1310 1320 1330 1340 1350 1360 940 950 960 970 980 990 KIAA15 KGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQP 1370 1380 1390 1400 1410 1420 1000 1010 1020 1030 1040 1050 KIAA15 SSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIE 1430 1440 1450 1460 1470 1480 1060 1070 1080 1090 1100 1110 KIAA15 DEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRP 1490 1500 1510 1520 1530 1540 1120 1130 1140 1150 1160 1170 KIAA15 RSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTK 1550 1560 1570 1580 1590 1600 1180 1190 1200 1210 1220 1230 KIAA15 EAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLP 1610 1620 1630 1640 1650 1660 1240 1250 1260 1270 1280 1290 KIAA15 QGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGM 1670 1680 1690 1700 1710 1720 1300 1310 KIAA15 NMQAFPTSSVQNPATIPPGPK ::::::.:::::::::::::: gi|114 NMQAFPSSSVQNPATIPPGPK 1730 1740 >>gi|109130874|ref|XP_001089789.1| PREDICTED: WNK lysine (1740 aa) initn: 4497 init1: 3832 opt: 8290 Z-score: 8302.9 bits: 1549.0 E(): 0 Smith-Waterman score: 8290; 97.178% identity (98.627% similar) in 1311 aa overlap (3-1313:433-1740) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|109 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS ::::: ::.::::::::::::::::::::::::::::::::.:::::::::::::::::: gi|109 NTTLPPAPTQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVAGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL :::::::::::::::::::::::::.::::::::::::::::::::::::. :::::::: gi|109 SQPSVAYSSNQTMGSQMVSNIPQAEINVPGQIYSSQQLVGHYQQVSGLQKQPKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL ::::::::::::::::::::::::::::::::::::::::::::.:: :::::::::::: gi|109 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGVEQ-AALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::: :::.::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 NQDVATMKENISSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHS 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 ATERAIGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::.::: .::::::::::::: :::::::::::::::::::::::::: gi|109 ETQSPPSLQHSMSSVPGLYPLPSPKNTSNKEIPPDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::: :::::::.:: :::::::::::::: gi|109 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSCSYSTTSVHAVRAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::.:::::::::::::::::::::::::: ::::::: gi|109 PVYPCHQTASQADALMSHPGESTQTAGNSLTTLAFDQKPQTLSVQQPAMDAECISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: gi|109 TVNTEASSPKTVIPTQTPGLEPPTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|109 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIQDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI ::::::::::::.::::::::::::::: ::::::::::::::::::::::::::::::: gi|109 SKLLSNVAASQPTNISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 830 840 850 860 870 KIAA15 HLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: gi|109 HLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQ-SAK 1250 1260 1270 1280 1290 1300 880 890 900 910 920 930 KIAA15 MTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKEN .:::::::::::::::::::::::..:::::::::::::::::::: ::::::::::::: gi|109 VTSFGIEHISVFSETNHSSEEAFIEAAKSQLVEIEPATQNPKTSFSSEKLQALQETCKEN 1310 1320 1330 1340 1350 1360 940 950 960 970 980 990 KIAA15 KGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQP :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: gi|109 KGVPKQGDNFLSFSAACETDVSSVTPEKELEETSATGSSMQSGSELLLKEREILTAGKQP 1370 1380 1390 1400 1410 1420 1000 1010 1020 1030 1040 1050 KIAA15 SSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIE ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|109 SSDSEFSASLAGSGKSVAKTGPESDQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIE 1430 1440 1450 1460 1470 1480 1060 1070 1080 1090 1100 1110 KIAA15 DEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 DEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRP 1490 1500 1510 1520 1530 1540 1120 1130 1140 1150 1160 1170 KIAA15 RSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTK 1550 1560 1570 1580 1590 1600 1180 1190 1200 1210 1220 1230 KIAA15 EAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLP :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: gi|109 EAVGNSLIKPSLNQLKQSQHKLETENWNKVYENTPSTMGYTSTWISSLSQIRGAVPTSLP 1610 1620 1630 1640 1650 1660 1240 1250 1260 1270 1280 1290 KIAA15 QGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGM ::::::::::::::::::::::::::.::::::::::::::::::::::.::::::::: gi|109 QGLSLPSFPGPLSSYGMPHVCQYNAVGGAGYPVQWVGISGTTQQSVVIPTQSGGPFQPG- 1670 1680 1690 1700 1710 1300 1310 KIAA15 NMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::: gi|109 NMQAFPTSSVQNPATIPPGPK 1720 1730 1740 >>gi|149758014|ref|XP_001495798.1| PREDICTED: similar to (1745 aa) initn: 5971 init1: 3492 opt: 7590 Z-score: 7601.2 bits: 1419.2 E(): 0 Smith-Waterman score: 7590; 87.747% identity (96.043% similar) in 1314 aa overlap (3-1313:433-1745) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|149 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ ::::::::::::::::::::::::::: ::::::::: ::.::::::::::.::..:: : gi|149 AYEMVKSGFFHESDSKAVAKSIRDRVTLIKKTREKKPPGCFEERRDSQCKSVGNILPQHQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS ::::: ::::.:::::::::::::::::::. ::::: ::::::.::::::.:: ::::: gi|149 NTTLPPAPAQHTGAECEETEVDQHVRQQLLRGKPQQHSSSVTGDSLSEAGAGSVKHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL :::..::::.: :::::::::::::.::::.:: ::::::::::.:::::. ::::: :: gi|149 SQPNIAYSSDQMMGSQMVSNIPQAEINVPGKIYPSQQLVGHYQQISGLQKQPKLTQPPIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL ::::::::::::::::: ::::::::::::::: :.:::::::::::::.:::::::::: gi|149 PLVQGQSTVLPVHVLGPPVVSQPQVSPLTVQKVSQVKPVSQPVGAEQQATLLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :.:::..:::...::::::::::::::::::::::::::::::::::::::::::::::: gi|149 NHDVAAVKENTNTPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHS 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :.::: ::::.::. :::::::::::::::. :.:::::::::::::::::::::::::: gi|149 AAERAIGVDSVTVEPNSSQTGSSEQVQINSAPTHTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :.:::::.: ::::::: .: ::.::::::::.:::::.:::::.:.:::::::::::: gi|149 EAQSPPSFQPSMSAVPGLQPHFSPRNTSNKEISQDTLLTLENNPCQRVLFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::: ::::::::::.:::::.:::::::..::::..:::.:::.::::::.:::.:. gi|149 DGKISEYASVETKQPAIFYQVEDDRQIMAPVATSSSYTATSVHAVPVECEGLTNQASMFL 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAF--DQKPQTLSVQQPAMDAEFISQEG :::::::.:.:::.::.::::::: .:::::: : :::::.: ::::.::.::::::: gi|149 PVYPCHQAANQADVLMAHPGESTQIAGNSLTTPACMSDQKPQSL-VQQPTMDTEFISQEG 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 ETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNL :::::::::: : :::::::.:::::: ::::::::::::::.::::::::::::::::: gi|149 ETTVNTEASSSKMVIPTQTPSLEPTTLLPTTVLESDGERPPKMEFADNRIKTLDEKLRNL 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQ ::::::::::::::::::::::::::::::::::::: ::.:::::::.:::.::::::: gi|149 LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVPEVVAISHCGIQDSPAQSPNFQQ 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 TGSKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGG ::::.:::::::::.::::::::::::::: ::::::::: ::::::::::::::::.:: gi|149 TGSKILSNVAASQPTNISVFKRDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSGGG 1190 1200 1210 1220 1230 1240 820 830 840 850 860 870 KIAA15 AIHLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQS :::::::::::. :::.:::::::: :::::::::.::::::::::::::::::.::::: gi|149 AIHLQTGVETEDRRSAVAPDPIPLTGESTADTRALSRCKAMSGSFQRGRFQVITVPQQQS 1250 1260 1270 1280 1290 1300 880 890 900 910 920 KIAA15 AKMTSFGIEHISVFSE-TNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETC .:.::::.::: .::: :.::::::: .::::.:::.::::.::.:::: .::: :.:: gi|149 VKVTSFGVEHIPAFSEMTSHSSEEAFTETAKSHLVEMEPATHNPQTSFSSQKLQFLHETF 1310 1320 1330 1340 1350 1360 930 940 950 960 970 980 KIAA15 KENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAG ::.: .:::::.: :::.::::::::.:::::.::.::::::::::::::.:: ::::.: gi|149 KEDKRIPKQGDKFSSFSTACETDVSSMTPEKELEENSATGSSMQSGSELLVKEIEILTVG 1370 1380 1390 1400 1410 1420 990 1000 1010 1020 1030 1040 KIAA15 KQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDES :::.:::::::.:.:.:::::::::::.:::: ::.::::.:::::::::::::::::: gi|149 KQPGSDSEFSAALSGKGKSVAKTGPESDQCLPLGEEKAYAQAQSSLFYSPSSPMSSDDES 1430 1440 1450 1460 1470 1480 1050 1060 1070 1080 1090 1100 KIAA15 EIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASP :::::::::::::::::::::::::::::::::::::::::.:::::.::.::::::::: gi|149 EIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRAIKDSKVQSSEIPLPPASP 1490 1500 1510 1520 1530 1540 1110 1120 1130 1140 1150 1160 KIAA15 RRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDD ::::::::::::::::::.:::: :::::::::::::::::::::::::::::::::::: gi|149 RRPRSFKSKLRSRPQSLTQVDNGAVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDD 1550 1560 1570 1580 1590 1600 1170 1180 1190 1200 1210 1220 KIAA15 WTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPT ::::.:::::::::::::::::::.::.::::: :::::::::::::::::::::::.:: gi|149 WTKETVGNSLIKPSLNQLKQSQHKVETDNWNKVHENTPSTMGYTSTWISSLSQIRGAAPT 1610 1620 1630 1640 1650 1660 1230 1240 1250 1260 1270 1280 KIAA15 SLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQ :::::::::::: ::::::::::::::::.: :::::::::::: :::::::.:::.::: gi|149 SLPQGLSLPSFPRPLSSYGMPHVCQYNAVGGPGYPVQWVGISGTPQQSVVIPTQSGAPFQ 1670 1680 1690 1700 1710 1720 1290 1300 1310 KIAA15 PGMNMQAFPTSSVQNPATIPPGPK ::::.::::.::::::.::::::: gi|149 PGMNLQAFPASSVQNPSTIPPGPK 1730 1740 >>gi|74007027|ref|XP_864627.1| PREDICTED: similar to Ser (1748 aa) initn: 7249 init1: 3329 opt: 7268 Z-score: 7278.4 bits: 1359.5 E(): 0 Smith-Waterman score: 7268; 84.271% identity (93.997% similar) in 1316 aa overlap (3-1313:433-1748) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::: ::: gi|740 AFFAEDTGLRVELAEEDDSSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTSEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ ::::::::::::::::::::::::::: :::::::::.:::::::::: :: :::. ::: gi|740 AYEMVKSGFFHESDSKAVAKSIRDRVTLIKKTREKKPSGCLEERRDSQSKSAGNVLLQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS ::::: ::::.:::::::::::::::::::.::::: :::::::::.::.:..::::: gi|740 NTTLPSAPAQHTGAECEETEVDQHVRQQLLKRKPQQPHPSVTGDNLSEVGAGSAVHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL ::::.::::.: ::::.:::: ::: ::::.:: ::::::::::.::::.. :::::.:: gi|740 SQPSIAYSSDQMMGSQVVSNISQAERNVPGMIYPSQQLVGHYQQISGLQQQPKLTQPHIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL :::::::.::::.:::: ::.:::::::::::. :.::::: .: :::::.::::::::: gi|740 PLVQGQSSVLPVRVLGPPVVAQPQVSPLTVQKISQMKPVSQAIGIEQQAAFLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :.::: .:::...:::: ::::::::::::::::::::::::::::::::.::::::::: gi|740 NHDVAFVKENINTPDNPCGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: gi|740 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQETLHVHS 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :..:: :.::: :. ::.::::::::::.:.::::::::: ::::::::::::::::::: gi|740 AADRAIGIDSIIVEPNSGQTGSSEQVQISSASTQTSNESASQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :.:::::::.:.:.::: ::::..:::::.:.::: :.:.:::.:.::.:::: :::: gi|740 EVQSPPSLQQSLSTVPGLSRLPSPRTTSNKELSQDTLPTLESNPCQRVLFASKSELKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::: ::::::.::..:::::.::::::::.::::..:::::: .::::::.::.::. gi|740 DGKISEYASVETKHPAVFYQVEDDRQIMAPVTSSSSYTATSVRAVAVECEGLTNQAGIFL 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAF--DQKPQTLSVQQPAMDAEFISQEG :::::::.:::::.:: :::::: .::::::::: :::::.: ::::.:::::::::: gi|740 PVYPCHQAASQADVLMVPPGESTQIAGNSLTTLAFMSDQKPQSLVVQQPSMDAEFISQEG 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 ETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNL :::.:::::::: ::::::::::::.: ::.::::.::::::.::::::::::::::::: gi|740 ETTMNTEASSPKMVIPTQTPGLEPTALLPTAVLESEGERPPKMEFADNRIKTLDEKLRNL 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQ ::::::::::::::::::::::::::::::::::::: :::.::: :..:::.::::::: gi|740 LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVPEVIGISHSGLQDSPAQSPNFQQ 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 TGSKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGG ::::.: ::::::::::::::::::::::. ::::::::: ::::::::::::::::::: gi|740 TGSKILFNVAASQPANISVFKRDLNVITSIPSELCLHEMSPDASLPGDPEAYPAAVSSGG 1190 1200 1210 1220 1230 1240 820 830 840 850 860 870 KIAA15 AIHLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQS :::::::::::. :::..::::::: :::::::::.::::::::::::::::::.::::: gi|740 AIHLQTGVETEDRRSAVGPDPIPLTGESTADTRALSRCKAMSGSFQRGRFQVITVPQQQS 1250 1260 1270 1280 1290 1300 880 890 900 910 920 KIAA15 AKMTSFGIEHISVFSE-TNHSSEE--AFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQE .:.::::::. .:.. :.::::: :: :::::::.::::.::.::. .::..:.: gi|740 VKVTSFGIERTPAFNKLTTHSSEEVLAFTDMAKSQLVEMEPATHNPQTSLPSQKLRVLHE 1310 1320 1330 1340 1350 1360 930 940 950 960 970 980 KIAA15 TCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILT : ::.: . :::::. :::.: :.::::.:::::. :.::: ::..:: :::::::::: gi|740 TFKEDKKILKQGDNLTSFSTAHEADVSSMTPEKELGENSATESSVHSGLELLLKEREILI 1370 1380 1390 1400 1410 1420 990 1000 1010 1020 1030 1040 KIAA15 AGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDD :::::::::::::.:: :::::.:::::.:::: .::.: :: :::::::::::::::: gi|740 AGKQPSSDSEFSATLAVRGKSVANTGPESGQCLPLREEKACAQIQSSLFYSPSSPMSSDD 1430 1440 1450 1460 1470 1480 1050 1060 1070 1080 1090 1100 KIAA15 ESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPA ::::::::::.::::::::::::::::::::::::::::::::.::::: ::.:.: ::. gi|740 ESEIEDEDLKAELQRLREKHIQEVVNLQTQQNKELQELYERLRAIKDSKIQSSEVPQPPS 1490 1500 1510 1520 1530 1540 1110 1120 1130 1140 1150 1160 KIAA15 SPRRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLV ::::::::::::::::::::.::.: .:.::::::::.:::::::::::::::::::::: gi|740 SPRRPRSFKSKLRSRPQSLTQVDSGAAAADPLCVESNVASCQQSPASKKGMFTDDLHKLV 1550 1560 1570 1580 1590 1600 1170 1180 1190 1200 1210 1220 KIAA15 DDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAV ::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::: gi|740 DDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVYENTPSTMGYTSTWISSLSQIRGAV 1610 1620 1630 1640 1650 1660 1230 1240 1250 1260 1270 1280 KIAA15 PTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGP :::.:::: ::::::::::::::::::::::.: :::::::::::: :::::::.::::: gi|740 PTSMPQGLPLPSFPGPLSSYGMPHVCQYNAVGGPGYPVQWVGISGTPQQSVVIPTQSGGP 1670 1680 1690 1700 1710 1720 1290 1300 1310 KIAA15 FQPGMNMQAFPTSSVQNPATIPPGPK ::::::.::::.::::::..:::::: gi|740 FQPGMNLQAFPASSVQNPSAIPPGPK 1730 1740 >>gi|74007023|ref|XP_864589.1| PREDICTED: similar to Ser (1786 aa) initn: 7249 init1: 3329 opt: 7268 Z-score: 7278.3 bits: 1359.5 E(): 0 Smith-Waterman score: 7268; 84.271% identity (93.997% similar) in 1316 aa overlap (3-1313:471-1786) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::: ::: gi|740 AFFAEDTGLRVELAEEDDSSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTSEEV 450 460 470 480 490 500 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ ::::::::::::::::::::::::::: :::::::::.:::::::::: :: :::. ::: gi|740 AYEMVKSGFFHESDSKAVAKSIRDRVTLIKKTREKKPSGCLEERRDSQSKSAGNVLLQPQ 510 520 530 540 550 560 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS ::::: ::::.:::::::::::::::::::.::::: :::::::::.::.:..::::: gi|740 NTTLPSAPAQHTGAECEETEVDQHVRQQLLKRKPQQPHPSVTGDNLSEVGAGSAVHSDTS 570 580 590 600 610 620 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL ::::.::::.: ::::.:::: ::: ::::.:: ::::::::::.::::.. :::::.:: gi|740 SQPSIAYSSDQMMGSQVVSNISQAERNVPGMIYPSQQLVGHYQQISGLQQQPKLTQPHIL 630 640 650 660 670 680 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL :::::::.::::.:::: ::.:::::::::::. :.::::: .: :::::.::::::::: gi|740 PLVQGQSSVLPVRVLGPPVVAQPQVSPLTVQKISQMKPVSQAIGIEQQAAFLKPDLVRSL 690 700 710 720 730 740 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :.::: .:::...:::: ::::::::::::::::::::::::::::::::.::::::::: gi|740 NHDVAFVKENINTPDNPCGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQ 750 760 770 780 790 800 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: gi|740 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQETLHVHS 810 820 830 840 850 860 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :..:: :.::: :. ::.::::::::::.:.::::::::: ::::::::::::::::::: gi|740 AADRAIGIDSIIVEPNSGQTGSSEQVQISSASTQTSNESASQSSPVGRWRFCINQTIRNR 870 880 890 900 910 920 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :.:::::::.:.:.::: ::::..:::::.:.::: :.:.:::.:.::.:::: :::: gi|740 EVQSPPSLQQSLSTVPGLSRLPSPRTTSNKELSQDTLPTLESNPCQRVLFASKSELKDVV 930 940 950 960 970 980 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::: ::::::.::..:::::.::::::::.::::..:::::: .::::::.::.::. gi|740 DGKISEYASVETKHPAVFYQVEDDRQIMAPVTSSSSYTATSVRAVAVECEGLTNQAGIFL 990 1000 1010 1020 1030 1040 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAF--DQKPQTLSVQQPAMDAEFISQEG :::::::.:::::.:: :::::: .::::::::: :::::.: ::::.:::::::::: gi|740 PVYPCHQAASQADVLMVPPGESTQIAGNSLTTLAFMSDQKPQSLVVQQPSMDAEFISQEG 1050 1060 1070 1080 1090 1100 640 650 660 670 680 690 KIAA15 ETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNL :::.:::::::: ::::::::::::.: ::.::::.::::::.::::::::::::::::: gi|740 ETTMNTEASSPKMVIPTQTPGLEPTALLPTAVLESEGERPPKMEFADNRIKTLDEKLRNL 1110 1120 1130 1140 1150 1160 700 710 720 730 740 750 KIAA15 LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQ ::::::::::::::::::::::::::::::::::::: :::.::: :..:::.::::::: gi|740 LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVPEVIGISHSGLQDSPAQSPNFQQ 1170 1180 1190 1200 1210 1220 760 770 780 790 800 810 KIAA15 TGSKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGG ::::.: ::::::::::::::::::::::. ::::::::: ::::::::::::::::::: gi|740 TGSKILFNVAASQPANISVFKRDLNVITSIPSELCLHEMSPDASLPGDPEAYPAAVSSGG 1230 1240 1250 1260 1270 1280 820 830 840 850 860 870 KIAA15 AIHLQTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQS :::::::::::. :::..::::::: :::::::::.::::::::::::::::::.::::: gi|740 AIHLQTGVETEDRRSAVGPDPIPLTGESTADTRALSRCKAMSGSFQRGRFQVITVPQQQS 1290 1300 1310 1320 1330 1340 880 890 900 910 920 KIAA15 AKMTSFGIEHISVFSE-TNHSSEE--AFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQE .:.::::::. .:.. :.::::: :: :::::::.::::.::.::. .::..:.: gi|740 VKVTSFGIERTPAFNKLTTHSSEEVLAFTDMAKSQLVEMEPATHNPQTSLPSQKLRVLHE 1350 1360 1370 1380 1390 1400 930 940 950 960 970 980 KIAA15 TCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILT : ::.: . :::::. :::.: :.::::.:::::. :.::: ::..:: :::::::::: gi|740 TFKEDKKILKQGDNLTSFSTAHEADVSSMTPEKELGENSATESSVHSGLELLLKEREILI 1410 1420 1430 1440 1450 1460 990 1000 1010 1020 1030 1040 KIAA15 AGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDD :::::::::::::.:: :::::.:::::.:::: .::.: :: :::::::::::::::: gi|740 AGKQPSSDSEFSATLAVRGKSVANTGPESGQCLPLREEKACAQIQSSLFYSPSSPMSSDD 1470 1480 1490 1500 1510 1520 1050 1060 1070 1080 1090 1100 KIAA15 ESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPA ::::::::::.::::::::::::::::::::::::::::::::.::::: ::.:.: ::. gi|740 ESEIEDEDLKAELQRLREKHIQEVVNLQTQQNKELQELYERLRAIKDSKIQSSEVPQPPS 1530 1540 1550 1560 1570 1580 1110 1120 1130 1140 1150 1160 KIAA15 SPRRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLV ::::::::::::::::::::.::.: .:.::::::::.:::::::::::::::::::::: gi|740 SPRRPRSFKSKLRSRPQSLTQVDSGAAAADPLCVESNVASCQQSPASKKGMFTDDLHKLV 1590 1600 1610 1620 1630 1640 1170 1180 1190 1200 1210 1220 KIAA15 DDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAV ::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::: gi|740 DDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVYENTPSTMGYTSTWISSLSQIRGAV 1650 1660 1670 1680 1690 1700 1230 1240 1250 1260 1270 1280 KIAA15 PTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGP :::.:::: ::::::::::::::::::::::.: :::::::::::: :::::::.::::: gi|740 PTSMPQGLPLPSFPGPLSSYGMPHVCQYNAVGGPGYPVQWVGISGTPQQSVVIPTQSGGP 1710 1720 1730 1740 1750 1760 1290 1300 1310 KIAA15 FQPGMNMQAFPTSSVQNPATIPPGPK ::::::.::::.::::::..:::::: gi|740 FQPGMNLQAFPASSVQNPSAIPPGPK 1770 1780 >>gi|57209549|emb|CAI40707.1| WNK lysine deficient prote (1790 aa) initn: 8545 init1: 5308 opt: 5335 Z-score: 5340.8 bits: 1001.0 E(): 0 Smith-Waterman score: 8455; 96.465% identity (96.465% similar) in 1358 aa overlap (3-1313:433-1790) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|572 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|572 SKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 KIAA15 HLQTG-----------------------------------------------VETEEMRS ::::: :::::::: gi|572 HLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRS 1250 1260 1270 1280 1290 1300 830 840 850 860 870 880 KIAA15 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS 1310 1320 1330 1340 1350 1360 890 900 910 920 930 940 KIAA15 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF 1370 1380 1390 1400 1410 1420 950 960 970 980 990 1000 KIAA15 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS 1430 1440 1450 1460 1470 1480 1010 1020 1030 1040 1050 1060 KIAA15 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE 1490 1500 1510 1520 1530 1540 1070 1080 1090 1100 1110 1120 KIAA15 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS 1550 1560 1570 1580 1590 1600 1130 1140 1150 1160 1170 1180 KIAA15 LTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 LTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLN 1610 1620 1630 1640 1650 1660 1190 1200 1210 1220 1230 1240 KIAA15 QLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 QLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLS 1670 1680 1690 1700 1710 1720 1250 1260 1270 1280 1290 1300 KIAA15 SYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|572 SYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNP 1730 1740 1750 1760 1770 1780 1310 KIAA15 ATIPPGPK :::::::: gi|572 ATIPPGPK 1790 >>gi|19908348|gb|AAL99253.1| putative protein kinase WNK (1800 aa) initn: 8525 init1: 5308 opt: 5335 Z-score: 5340.7 bits: 1001.0 E(): 0 Smith-Waterman score: 8419; 95.687% identity (95.760% similar) in 1368 aa overlap (3-1313:433-1800) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|199 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|199 SKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 KIAA15 HLQTG-----------------------------------------------VETEEMRS ::::: :::::::: gi|199 HLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRS 1250 1260 1270 1280 1290 1300 830 840 850 860 870 880 KIAA15 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS 1310 1320 1330 1340 1350 1360 890 900 910 920 930 940 KIAA15 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF 1370 1380 1390 1400 1410 1420 950 960 970 980 990 1000 KIAA15 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS 1430 1440 1450 1460 1470 1480 1010 1020 1030 1040 1050 1060 KIAA15 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE 1490 1500 1510 1520 1530 1540 1070 1080 1090 1100 1110 1120 KIAA15 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS 1550 1560 1570 1580 1590 1600 1130 1140 1150 1160 1170 KIAA15 LTHVDNGIVAT----------DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAV ::::::::::: .:::::::::::::::::::::::::::::::::::::: gi|199 LTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAV 1610 1620 1630 1640 1650 1660 1180 1190 1200 1210 1220 1230 KIAA15 GNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 GNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGL 1670 1680 1690 1700 1710 1720 1240 1250 1260 1270 1280 1290 KIAA15 SLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|199 SLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQ 1730 1740 1750 1760 1770 1780 1300 1310 KIAA15 AFPTSSVQNPATIPPGPK :::::::::::::::::: gi|199 AFPTSSVQNPATIPPGPK 1790 1800 >>gi|40738019|gb|AAR89465.1| putative protein kinase WNK (1800 aa) initn: 8525 init1: 5308 opt: 5335 Z-score: 5340.7 bits: 1001.0 E(): 0 Smith-Waterman score: 8419; 95.687% identity (95.760% similar) in 1368 aa overlap (3-1313:433-1800) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|407 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|407 SKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 KIAA15 HLQTG-----------------------------------------------VETEEMRS ::::: :::::::: gi|407 HLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRS 1250 1260 1270 1280 1290 1300 830 840 850 860 870 880 KIAA15 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS 1310 1320 1330 1340 1350 1360 890 900 910 920 930 940 KIAA15 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF 1370 1380 1390 1400 1410 1420 950 960 970 980 990 1000 KIAA15 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS 1430 1440 1450 1460 1470 1480 1010 1020 1030 1040 1050 1060 KIAA15 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE 1490 1500 1510 1520 1530 1540 1070 1080 1090 1100 1110 1120 KIAA15 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS 1550 1560 1570 1580 1590 1600 1130 1140 1150 1160 1170 KIAA15 LTHVDNGIVAT----------DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAV ::::::::::: .:::::::::::::::::::::::::::::::::::::: gi|407 LTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAV 1610 1620 1630 1640 1650 1660 1180 1190 1200 1210 1220 1230 KIAA15 GNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 GNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGL 1670 1680 1690 1700 1710 1720 1240 1250 1260 1270 1280 1290 KIAA15 SLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|407 SLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQ 1730 1740 1750 1760 1770 1780 1300 1310 KIAA15 AFPTSSVQNPATIPPGPK :::::::::::::::::: gi|407 AFPTSSVQNPATIPPGPK 1790 1800 >>gi|114688771|ref|XP_521078.2| PREDICTED: WNK lysine de (1800 aa) initn: 8480 init1: 5281 opt: 5311 Z-score: 5316.7 bits: 996.5 E(): 0 Smith-Waterman score: 8374; 95.102% identity (95.614% similar) in 1368 aa overlap (3-1313:433-1800) 10 20 30 KIAA15 RDEDPKKLKGKHKDNEAIEFSFNLETDTPEEV :::::::::::::::::::::::::::::: gi|114 AFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEV 410 420 430 440 450 460 40 50 60 70 80 90 KIAA15 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQ 470 480 490 500 510 520 100 110 120 130 140 150 KIAA15 NTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: gi|114 NTTLPLAPAQQSGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTS 530 540 550 560 570 580 160 170 180 190 200 210 KIAA15 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQIL ::::::::::::::::::::::::::::::::::::::::::::::::::. :::::::: gi|114 SQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKQPKLTQPQIL 590 600 610 620 630 640 220 230 240 250 260 270 KIAA15 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSL ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|114 PLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGVEQQAALLKPDLVRSL 650 660 670 680 690 700 280 290 300 310 320 330 KIAA15 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 NQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQ 710 720 730 740 750 760 340 350 360 370 380 390 KIAA15 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHF 770 780 790 800 810 820 400 410 420 430 440 450 KIAA15 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNR 830 840 850 860 870 880 460 470 480 490 500 510 KIAA15 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVV 890 900 910 920 930 940 520 530 540 550 560 570 KIAA15 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFI 950 960 970 980 990 1000 580 590 600 610 620 630 KIAA15 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGET 1010 1020 1030 1040 1050 1060 640 650 660 670 680 690 KIAA15 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLY 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 KIAA15 QEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QEHSISNIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTG 1130 1140 1150 1160 1170 1180 760 770 780 790 800 810 KIAA15 SKLLSNVAASQPANISVFKRDLNVITSVSSELCLHEMSSDASLPGDPEAYPAAVSSGGAI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|114 SKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAI 1190 1200 1210 1220 1230 1240 820 KIAA15 HLQTG-----------------------------------------------VETEEMRS ::::: :::::::: gi|114 HLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRS 1250 1260 1270 1280 1290 1300 830 840 850 860 870 880 KIAA15 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFS 1310 1320 1330 1340 1350 1360 890 900 910 920 930 940 KIAA15 ETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSF :::::::::::.::::::::::::::::::::: :::::::::::::::::::::::::: gi|114 ETNHSSEEAFIETAKSQLVEIEPATQNPKTSFSSEKLQALQETCKENKGVPKQGDNFLSF 1370 1380 1390 1400 1410 1420 950 960 970 980 990 1000 KIAA15 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGS 1430 1440 1450 1460 1470 1480 1010 1020 1030 1040 1050 1060 KIAA15 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLRE 1490 1500 1510 1520 1530 1540 1070 1080 1090 1100 1110 1120 KIAA15 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQS 1550 1560 1570 1580 1590 1600 1130 1140 1150 1160 1170 KIAA15 LTHVDNGIVAT----------DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAV ::::::::::: .:::::::::::::::::::::::::::::::::::::: gi|114 LTHVDNGIVATGKSVIKNKMKNPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAV 1610 1620 1630 1640 1650 1660 1180 1190 1200 1210 1220 1230 KIAA15 GNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGL 1670 1680 1690 1700 1710 1720 1240 1250 1260 1270 1280 1290 KIAA15 SLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQ 1730 1740 1750 1760 1770 1780 1300 1310 KIAA15 AFPTSSVQNPATIPPGPK :::.:::::::::::::: gi|114 AFPSSSVQNPATIPPGPK 1790 1800 1313 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 03:04:32 2009 done: Thu Mar 5 03:08:03 2009 Total Scan time: 1802.000 Total Display time: 1.530 Function used was FASTA [version 34.26.5 April 26, 2007]