# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fg04087.fasta.nr -Q ../query/KIAA1149.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1149, 532 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7824246 sequences Expectation_n fit: rho(ln(x))= 5.1274+/-0.000184; mu= 12.8000+/- 0.010 mean_var=79.0390+/-15.512, 0's: 32 Z-trim: 43 B-trim: 110 in 2/63 Lambda= 0.144263 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|6685248|sp|P56817.1|BACE1_HUMAN RecName: Full=B ( 501) 3187 672.9 5.9e-191 gi|6470293|gb|AAF13715.1|AF200193_1 memapsin 2 [Ho ( 488) 3181 671.6 1.4e-190 gi|23273579|gb|AAH36084.1| Beta-site APP-cleaving ( 501) 3179 671.2 1.9e-190 gi|167887469|gb|ACA05927.1| beta-secretase 1 precu ( 501) 3176 670.6 2.9e-190 gi|109108794|ref|XP_001094263.1| PREDICTED: beta-s ( 501) 3174 670.2 3.8e-190 gi|110278889|sp|Q2HJ40.1|BACE1_BOVIN RecName: Full ( 501) 3143 663.7 3.4e-188 gi|6685233|sp|P56819.1|BACE1_RAT RecName: Full=Bet ( 501) 3137 662.5 8e-188 gi|18268203|sp|P56818.2|BACE1_MOUSE RecName: Full= ( 501) 3134 661.8 1.2e-187 gi|26340362|dbj|BAC33844.1| unnamed protein produc ( 501) 3133 661.6 1.4e-187 gi|26337869|dbj|BAC32620.1| unnamed protein produc ( 501) 3128 660.6 2.9e-187 gi|126326602|ref|XP_001370781.1| PREDICTED: simila ( 500) 3009 635.8 8.3e-180 gi|149606590|ref|XP_001509790.1| PREDICTED: simila ( 498) 2913 615.8 8.6e-174 gi|126030615|pdb|2HIZ|A Chain A, Crystal Structure ( 455) 2839 600.4 3.5e-169 gi|193786733|dbj|BAG52056.1| unnamed protein produ ( 427) 2833 599.1 7.9e-169 gi|160286142|pdb|2VA5|A Chain A, X-Ray Crystal Str ( 455) 2831 598.7 1.1e-168 gi|114640540|ref|XP_508778.2| PREDICTED: beta-site ( 415) 2810 594.3 2.1e-167 gi|73955096|ref|XP_546508.2| PREDICTED: similar to ( 429) 2808 593.9 2.9e-167 gi|189339636|pdb|3CKP|A Chain A, Crystal Structure ( 412) 2774 586.8 3.8e-165 gi|55670609|pdb|1W50|A Chain A, Apo Structure Of B ( 411) 2769 585.8 7.8e-165 gi|222447065|pdb|3EXO|A Chain A, Crystal Structure ( 413) 2768 585.6 9.1e-165 gi|185177712|pdb|2ZHR|A Chain A, Crystal Structure ( 411) 2767 585.4 1e-164 gi|195927261|pdb|2QU2|A Chain A, Bace1 With Compou ( 415) 2760 583.9 2.9e-164 gi|169791850|pdb|3BRA|A Chain A, Bace-1 Complexed ( 409) 2753 582.5 7.8e-164 gi|88191839|pdb|1YM4|A Chain A, Crystal Structure ( 408) 2744 580.6 2.9e-163 gi|218681771|pdb|3DM6|A Chain A, Beta-Secretase 1 ( 406) 2741 580.0 4.4e-163 gi|221046549|pdb|2ZJN|A Chain A, Crystal Structure ( 405) 2731 577.9 1.9e-162 gi|221046544|pdb|2ZJK|A Chain A, Crystal Structure ( 405) 2725 576.6 4.4e-162 gi|221046542|pdb|2ZJI|A Chain A, Crystal Structure ( 405) 2725 576.6 4.4e-162 gi|221046541|pdb|2ZJH|A Chain A, Crystal Structure ( 405) 2725 576.6 4.4e-162 gi|56966092|pdb|1TQF|A Chain A, Crystal Structure ( 405) 2717 575.0 1.4e-161 gi|185177596|pdb|2QZL|A Chain A, Crystal Structure ( 411) 2717 575.0 1.4e-161 gi|221046543|pdb|2ZJJ|A Chain A, Crystal Structure ( 405) 2711 573.7 3.3e-161 gi|145580015|pdb|2OF0|A Chain A, X-Ray Crystal Str ( 402) 2708 573.1 5.1e-161 gi|88191836|pdb|1YM2|A Chain A, Crystal Structure ( 402) 2703 572.0 1.1e-160 gi|126030622|pdb|2HM1|A Chain A, Crystal Structure ( 406) 2677 566.6 4.5e-159 gi|118101972|ref|XP_417908.2| PREDICTED: hypotheti ( 423) 2677 566.7 4.6e-159 gi|112419063|gb|AAI21913.1| Beta-site APP-cleaving ( 502) 2677 566.7 5.3e-159 gi|169791700|pdb|2QK5|A Chain A, Structure Of Bace ( 395) 2651 561.2 1.9e-157 gi|11514162|pdb|1FKN|A Chain A, Structure Of Beta- ( 391) 2638 558.5 1.2e-156 gi|190016335|pdb|3CIB|A Chain A, Structure Of Bace ( 390) 2629 556.6 4.4e-156 gi|48425684|pdb|1SGZ|A Chain A, Crystal Structure ( 389) 2624 555.6 9.1e-156 gi|88192961|pdb|2FDP|A Chain A, Crystal Structure ( 388) 2616 553.9 2.9e-155 gi|166235438|pdb|2VIE|A Chain A, Human Bace-1 In C ( 392) 2616 553.9 2.9e-155 gi|114640542|ref|XP_001158264.1| PREDICTED: beta-s ( 401) 2607 552.1 1.1e-154 gi|119587719|gb|EAW67315.1| beta-site APP-cleaving ( 401) 2607 552.1 1.1e-154 gi|157835822|pdb|2Q11|A Chain A, Structure Of Bace ( 388) 2588 548.1 1.6e-153 gi|157835827|pdb|2Q15|A Chain A, Structure Of Bace ( 385) 2570 544.3 2.2e-152 gi|41944860|gb|AAH65973.1| Zgc:77409 [Danio rerio] ( 505) 2519 533.8 4.2e-149 gi|13699248|gb|AAK38375.1|AF338817_1 beta-site APP ( 457) 2144 455.7 1.2e-125 gi|109108798|ref|XP_001093918.1| PREDICTED: beta-s ( 457) 2135 453.9 4.5e-125 >>gi|6685248|sp|P56817.1|BACE1_HUMAN RecName: Full=Beta- (501 aa) initn: 3175 init1: 3175 opt: 3187 Z-score: 3584.5 bits: 672.9 E(): 5.9e-191 Smith-Waterman score: 3187; 96.341% identity (96.951% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL : :: : .: : : .. ::::: gi|668 MAQALPWLLLWMGAGVLP-AHGTQHGIRLPLRSGLGGAPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK :::::::::::::::::::::::::::::::::::::::::: gi|668 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 460 470 480 490 500 >>gi|6470293|gb|AAF13715.1|AF200193_1 memapsin 2 [Homo s (488 aa) initn: 3175 init1: 3175 opt: 3181 Z-score: 3577.9 bits: 671.6 E(): 1.4e-190 Smith-Waterman score: 3181; 97.325% identity (97.942% similar) in 486 aa overlap (49-532:4-488) 20 30 40 50 60 70 KIAA11 QCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPLGLRLPR :: : .: : : .. ::::::::::: gi|647 AGVLP-AHGTQHGIRLPLRSGLGGAPLGLRLPR 10 20 30 80 90 100 110 120 130 KIAA11 ETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 ETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAP 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 HPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 HPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITE 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 SDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 SDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQS 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 EVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 EVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 SIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 SIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVIS 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 LYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 LYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVV 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 FDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|647 FDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAI 400 410 420 430 440 450 500 510 520 530 KIAA11 CALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK :::::::::::::::::::::::::::::::::::: gi|647 CALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 460 470 480 >>gi|23273579|gb|AAH36084.1| Beta-site APP-cleaving enzy (501 aa) initn: 3167 init1: 3167 opt: 3179 Z-score: 3575.5 bits: 671.2 E(): 1.9e-190 Smith-Waterman score: 3179; 96.138% identity (96.748% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL : :: : .: : : .. ::::: gi|232 MAQALPWLLLWMGAGVLP-AHGTQHGIRLPLRSGLGGAPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: gi|232 AVGAAPHPFLHRYYQRQLFSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|232 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK :::::::::::::::::::::::::::::::::::::::::: gi|232 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 460 470 480 490 500 >>gi|167887469|gb|ACA05927.1| beta-secretase 1 precursor (501 aa) initn: 3164 init1: 3164 opt: 3176 Z-score: 3572.1 bits: 670.6 E(): 2.9e-190 Smith-Waterman score: 3176; 96.138% identity (96.748% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL : :: : .: : : .. ::::: gi|167 MAQALPWLLLWMGAGVLP-AHGTQHGIRLPLRSGLGGAPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|167 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK ::::::::::::::::::::: :::::::::::::::::::: gi|167 YVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK 460 470 480 490 500 >>gi|109108794|ref|XP_001094263.1| PREDICTED: beta-site (501 aa) initn: 3162 init1: 3162 opt: 3174 Z-score: 3569.9 bits: 670.2 E(): 3.8e-190 Smith-Waterman score: 3174; 95.935% identity (96.748% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL : :: : .: : : .. ::::. gi|109 MAQALPWLLLWMGAGVLP-AHGTQHGIRLPLRSGLGGAPV 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|109 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK :::::::::::::::::::::::::::::::::::::::::: gi|109 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 460 470 480 490 500 >>gi|110278889|sp|Q2HJ40.1|BACE1_BOVIN RecName: Full=Bet (501 aa) initn: 3134 init1: 3134 opt: 3143 Z-score: 3535.0 bits: 663.7 E(): 3.4e-188 Smith-Waterman score: 3143; 94.919% identity (96.341% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL : :: : .. : : .. ::::: gi|110 MAQALPWLLLWMGSGVLP-AHGSQPGIRLPLRSGLGGAPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF ::::::::::: :::::::::::::::::::::::::::::.:::::::::::::::::: gi|110 GLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTLGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|110 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|110 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::::.:::::::::::::::::: ::::::::::::::::::::::::::::::::: gi|110 FPLNQSEALASVGGSMIIGGIDHSLYMGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|110 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|110 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|110 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK ::::::::::::::::::::::::::::.::::::::::::: gi|110 YVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|6685233|sp|P56819.1|BACE1_RAT RecName: Full=Beta-se (501 aa) initn: 3127 init1: 3127 opt: 3137 Z-score: 3528.3 bits: 662.5 E(): 8e-188 Smith-Waterman score: 3137; 94.309% identity (96.748% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL :. :: : .: : : .. .: :: gi|668 MAPALRWLLLWVGSGMLP-AQGTHLGIRLPLRSGLAGPPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: gi|668 AVGAAPHPFLHRYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::: gi|668 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::.:.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 FPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|668 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|668 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK ::::::::::::::::::::::::::::.::::::::::::: gi|668 YVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|18268203|sp|P56818.2|BACE1_MOUSE RecName: Full=Beta (501 aa) initn: 3124 init1: 3124 opt: 3134 Z-score: 3524.9 bits: 661.8 E(): 1.2e-187 Smith-Waterman score: 3134; 94.309% identity (96.545% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL :. :: : .: : : .. .: :: gi|182 MAPALHWLLLWVGSGMLP-AQGTHLGIRLPLRSGLAGPPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: gi|182 GLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::: gi|182 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::.:.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 FPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|182 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|182 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK ::::::::::::::::::::::::::::.::::::::::::: gi|182 YVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|26340362|dbj|BAC33844.1| unnamed protein product [M (501 aa) initn: 3123 init1: 3123 opt: 3133 Z-score: 3523.8 bits: 661.6 E(): 1.4e-187 Smith-Waterman score: 3133; 94.106% identity (96.545% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL :. :: : .: : : .. .: :: gi|263 MAPALHWLLLWVGSGMLP-AQGTHLGIRLPLRSGLAGPPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF ::::::::::: :::::::::::::::::::::::::::::.:::::::::::::::::: gi|263 GLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTIGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::: gi|263 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::.:.:::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 FPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|263 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|263 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK ::::::::::::::::::::::::::::.::::::::::::: gi|263 YVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|26337869|dbj|BAC32620.1| unnamed protein product [M (501 aa) initn: 3118 init1: 3118 opt: 3128 Z-score: 3518.2 bits: 660.6 E(): 2.9e-187 Smith-Waterman score: 3128; 94.106% identity (96.341% similar) in 492 aa overlap (43-532:11-501) 20 30 40 50 60 70 KIAA11 PGTDVGQCEPRGPEGRGPPWPKPCPGSCCGWARECCLPTAPSTASGC--PCAAAWGGAPL :. :: : .: : : .. .: :: gi|263 MAPALHWLLLWVGSGMLP-AQGTHLGIRLPLRSGLAGPPL 10 20 30 80 90 100 110 120 130 KIAA11 GLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: gi|263 GLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAG :::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::: gi|263 IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAG 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 FPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCK :::::.:.:::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|263 FPLNQTEALASVGGSMIIGGIDHSLYTGRLWYTPIRREWYYEVIIVRVEINGQDLKMDCK 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 EYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWN 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|263 IFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIM 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|263 EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIA 400 410 420 430 440 450 500 510 520 530 KIAA11 YVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK ::::::::::::::::::::::::::::.::::::::::::: gi|263 YVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 532 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Tue Mar 3 22:27:30 2009 done: Tue Mar 3 22:31:57 2009 Total Scan time: 1568.210 Total Display time: 0.210 Function used was FASTA [version 34.26.5 April 26, 2007]