# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/hh00889b.fasta.nr -Q ../query/KIAA0608.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA0608, 775 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7819514 sequences Expectation_n fit: rho(ln(x))= 5.7801+/-0.000196; mu= 11.7578+/- 0.011 mean_var=104.6699+/-20.182, 0's: 24 Z-trim: 45 B-trim: 122 in 1/65 Lambda= 0.125361 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|114632000|ref|XP_507936.2| PREDICTED: TBC1 doma ( 862) 5268 963.8 0 gi|168267440|dbj|BAG09776.1| TBC1 domain family me ( 769) 5226 956.1 0 gi|115502463|sp|O60347.3|TBC12_HUMAN RecName: Full ( 775) 5204 952.1 0 gi|73998066|ref|XP_849591.1| PREDICTED: similar to ( 772) 4414 809.3 0 gi|109090045|ref|XP_001090278.1| PREDICTED: TBC1 d ( 732) 4082 749.2 1.3e-213 gi|126273232|ref|XP_001374921.1| PREDICTED: simila ( 777) 3704 680.8 5.2e-193 gi|194205839|ref|XP_001500836.2| PREDICTED: TBC1 d ( 742) 3684 677.2 6.2e-192 gi|73998064|ref|XP_859120.1| PREDICTED: similar to ( 698) 3313 610.1 9.4e-172 gi|182701375|sp|Q6A039.2|TBC12_MOUSE RecName: Full ( 696) 3284 604.8 3.5e-170 gi|148709865|gb|EDL41811.1| TBC1D12: TBC1 domain f ( 599) 3278 603.7 6.7e-170 gi|119943133|ref|NP_666064.3| TBC1D12: TBC1 domain ( 698) 3278 603.8 7.5e-170 gi|194041748|ref|XP_001926666.1| PREDICTED: TBC1 d ( 451) 2960 546.1 1.1e-152 gi|169642000|gb|AAI60725.1| LOC100158296 protein [ ( 596) 2764 510.7 6.5e-142 gi|118092832|ref|XP_001231528.1| PREDICTED: simila ( 404) 2524 467.2 5.7e-129 gi|123914313|sp|Q0IHY4.1|TBC12_XENTR RecName: Full ( 684) 2475 458.5 3.9e-126 gi|189530860|ref|XP_692080.2| PREDICTED: wu:fc59a0 ( 823) 2427 449.9 1.8e-123 gi|50949274|emb|CAB43225.2| hypothetical protein [ ( 352) 2327 431.5 2.7e-118 gi|194678953|ref|XP_585982.4| PREDICTED: similar t ( 352) 2308 428.1 3e-117 gi|149062801|gb|EDM13224.1| rCG47282 [Rattus norve ( 352) 2283 423.5 6.8e-116 gi|118090700|ref|XP_001232770.1| PREDICTED: simila ( 675) 2235 415.1 4.5e-113 gi|109073654|ref|XP_001118829.1| PREDICTED: simila ( 841) 2227 413.8 1.4e-112 gi|27371020|gb|AAH41167.1| TBC1 domain family, mem ( 678) 2225 413.3 1.6e-112 gi|126332070|ref|XP_001372247.1| PREDICTED: simila ( 692) 2225 413.3 1.6e-112 gi|172044690|sp|Q9P2M4.3|TBC14_HUMAN RecName: Full ( 693) 2225 413.3 1.6e-112 gi|168269810|dbj|BAG10032.1| TBC1 domain family me ( 693) 2225 413.3 1.6e-112 gi|114593160|ref|XP_526514.2| PREDICTED: TBC1 doma ( 816) 2225 413.4 1.8e-112 gi|194209331|ref|XP_001500016.2| PREDICTED: TBC1 d ( 693) 2224 413.1 1.8e-112 gi|148878131|gb|AAI46263.1| TBC1D14 protein [Bos t ( 677) 2219 412.2 3.3e-112 gi|189037433|sp|A6H7I8.2|TBC14_BOVIN RecName: Full ( 692) 2219 412.2 3.4e-112 gi|73951733|ref|XP_545899.2| PREDICTED: similar to ( 718) 2212 411.0 8.4e-112 gi|55728558|emb|CAH91021.1| hypothetical protein [ ( 518) 2191 407.0 9.2e-111 gi|71122315|gb|AAH99760.1| TBC1 domain family, mem ( 679) 2169 403.2 1.8e-109 gi|164565385|ref|NP_001029193.2| TBC1 domain famil ( 694) 2169 403.2 1.8e-109 gi|149047374|gb|EDM00044.1| TBC1 domain family, me ( 714) 2169 403.2 1.8e-109 gi|66396636|gb|AAH96446.1| TBC1 domain family, mem ( 679) 2166 402.6 2.6e-109 gi|27502771|gb|AAH42515.1| TBC1 domain family, mem ( 679) 2166 402.6 2.6e-109 gi|164565373|ref|NP_598671.3| TBC1 domain family, ( 694) 2166 402.6 2.6e-109 gi|189037431|sp|Q8CGA2.2|TBC14_MOUSE RecName: Full ( 694) 2166 402.6 2.6e-109 gi|148705561|gb|EDL37508.1| TBC1 domain family, me ( 714) 2166 402.7 2.7e-109 gi|189037432|sp|Q5CD77.2|TBC14_RAT RecName: Full=T ( 694) 2160 401.6 5.5e-109 gi|68363916|ref|XP_683181.1| PREDICTED: similar to ( 711) 2148 399.4 2.5e-108 gi|149784077|gb|ABR29562.1| spermatogenesis-relate ( 470) 2085 387.8 5.1e-105 gi|164565381|ref|NP_001106834.1| TBC1 domain famil ( 413) 2069 384.9 3.4e-104 gi|164565387|ref|NP_001012152.2| TBC1 domain famil ( 413) 2034 378.6 2.8e-102 gi|164565383|ref|NP_001106835.1| TBC1 domain famil ( 413) 2031 378.0 4e-102 gi|60735069|dbj|BAD91010.1| hypothetical protein [ ( 718) 2014 375.2 5e-101 gi|21739363|emb|CAD38726.1| hypothetical protein [ ( 381) 1944 362.3 2.1e-97 gi|15030293|gb|AAH11420.1| Tbc1d14 protein [Mus mu ( 353) 1765 329.8 1.1e-87 gi|48927597|dbj|BAD23893.1| Up-regulated in nephre ( 353) 1748 326.8 9.2e-87 gi|219519808|gb|AAI45130.1| Unknown (protein for M ( 621) 1749 327.2 1.2e-86 >>gi|114632000|ref|XP_507936.2| PREDICTED: TBC1 domain f (862 aa) initn: 5268 init1: 5268 opt: 5268 Z-score: 5149.5 bits: 963.8 E(): 0 Smith-Waterman score: 5268; 100.000% identity (100.000% similar) in 775 aa overlap (1-775:88-862) 10 20 30 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPD :::::::::::::::::::::::::::::: gi|114 TLRRLSPRPQHPELFSGQACACSPSLPPGAAATHPQMVGPEDAGACSGRNPKLLPVPAPD 60 70 80 90 100 110 40 50 60 70 80 90 KIAA06 PVGQDRKVIRATGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PVGQDRKVIRATGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPL 120 130 140 150 160 170 100 110 120 130 140 150 KIAA06 PAGQAGAPPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PAGQAGAPPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLE 180 190 200 210 220 230 160 170 180 190 200 210 KIAA06 EARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQ 240 250 260 270 280 290 220 230 240 250 260 270 KIAA06 EPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIH 300 310 320 330 340 350 280 290 300 310 320 330 KIAA06 FNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKR 360 370 380 390 400 410 340 350 360 370 380 390 KIAA06 TKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFE 420 430 440 450 460 470 400 410 420 430 440 450 KIAA06 PLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE 480 490 500 510 520 530 460 470 480 490 500 510 KIAA06 ENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYE 540 550 560 570 580 590 520 530 540 550 560 570 KIAA06 IFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDV 600 610 620 630 640 650 580 590 600 610 620 630 KIAA06 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM 660 670 680 690 700 710 640 650 660 670 680 690 KIAA06 MLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCR 720 730 740 750 760 770 700 710 720 730 740 750 KIAA06 DGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK 780 790 800 810 820 830 760 770 KIAA06 WTQVFASVMKDIKEGDKNSSPALKS ::::::::::::::::::::::::: gi|114 WTQVFASVMKDIKEGDKNSSPALKS 840 850 860 >>gi|168267440|dbj|BAG09776.1| TBC1 domain family member (769 aa) initn: 5226 init1: 5226 opt: 5226 Z-score: 5109.1 bits: 956.1 E(): 0 Smith-Waterman score: 5226; 100.000% identity (100.000% similar) in 769 aa overlap (7-775:1-769) 10 20 30 40 50 60 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADE :::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 MVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADE 10 20 30 40 50 70 80 90 100 110 120 KIAA06 EEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSKHRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 EEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSKHRGA 60 70 80 90 100 110 130 140 150 160 170 180 KIAA06 EVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEGPGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 EVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEGPGDE 120 130 140 150 160 170 190 200 210 220 230 240 KIAA06 DADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 DADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGA 180 190 200 210 220 230 250 260 270 280 290 300 KIAA06 GGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 GGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPA 240 250 260 270 280 290 310 320 330 340 350 360 KIAA06 AEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 AEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTS 300 310 320 330 340 350 370 380 390 400 410 420 KIAA06 KIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 KIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQE 360 370 380 390 400 410 430 440 450 460 470 480 KIAA06 YDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 YDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVREL 420 430 440 450 460 470 490 500 510 520 530 540 KIAA06 WWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 WWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADR 480 490 500 510 520 530 550 560 570 580 590 600 KIAA06 EASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 EASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLIL 540 550 560 570 580 590 610 620 630 640 650 660 KIAA06 NLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 NLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTP 600 610 620 630 640 650 670 680 690 700 710 720 KIAA06 DIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 DIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIA 660 670 680 690 700 710 730 740 750 760 770 KIAA06 QFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 QFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS 720 730 740 750 760 >>gi|115502463|sp|O60347.3|TBC12_HUMAN RecName: Full=TBC (775 aa) initn: 4875 init1: 4875 opt: 5204 Z-score: 5087.5 bits: 952.1 E(): 0 Smith-Waterman score: 5204; 99.226% identity (99.226% similar) in 775 aa overlap (7-775:1-775) 10 20 30 40 50 60 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADE :::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 MVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADE 10 20 30 40 50 70 80 90 100 110 KIAA06 EEE------TPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSG ::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 EEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSG 60 70 80 90 100 110 120 130 140 150 160 170 KIAA06 SKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 SKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRL 120 130 140 150 160 170 180 190 200 210 220 230 KIAA06 EGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 EGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSE 180 190 200 210 220 230 240 250 260 270 280 290 KIAA06 QRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 QRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGP 240 250 260 270 280 290 300 310 320 330 340 350 KIAA06 PVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 PVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRE 300 310 320 330 340 350 360 370 380 390 400 410 KIAA06 NLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 NLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEA 360 370 380 390 400 410 420 430 440 450 460 470 KIAA06 LRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 LRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRST 420 430 440 450 460 470 480 490 500 510 520 530 KIAA06 RRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 RRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEG 480 490 500 510 520 530 540 550 560 570 580 590 KIAA06 VSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 VSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFI 540 550 560 570 580 590 600 610 620 630 640 650 KIAA06 AAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 AAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFK 600 610 620 630 640 650 660 670 680 690 700 710 KIAA06 SYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 SYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQM 660 670 680 690 700 710 720 730 740 750 760 770 KIAA06 DFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 DFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALK 720 730 740 750 760 770 KIAA06 S : gi|115 S >>gi|73998066|ref|XP_849591.1| PREDICTED: similar to TBC (772 aa) initn: 3776 init1: 3200 opt: 4414 Z-score: 4315.4 bits: 809.3 E(): 0 Smith-Waterman score: 4414; 86.300% identity (91.677% similar) in 781 aa overlap (7-775:1-772) 10 20 30 40 50 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPP---EE :::::::::::::::::::::: .::::: :.::::::::::::::::: :: gi|739 MVGPEDAGACSGRNPKLLPVPALEPVGQDGKMIRATGGFGGGVGAVEPPAEEEE 10 20 30 40 50 60 70 80 90 100 110 KIAA06 ADEEEETPPRQLLQRYLAAAGE-QLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSK .:::::::.:::.::::::: ::: .:: :::: : : :: :::: ::: :::: gi|739 EEEEEETPPQQLLRRYLAAAGGGQLESALCSRPLPARQPRAAPPPAAPRPDACPRDSGSK 60 70 80 90 100 110 120 130 140 150 160 170 KIAA06 HRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEG .::: .:: :::::.:::::::::: :.: :::::::::::::::. ::: :: .: gi|739 RRGAAAADVRAPRHRGMTNGDSGFLAGQDSRDLEEARGLARAGGRDPSRRR----LRPQG 120 130 140 150 160 170 180 190 200 210 220 230 KIAA06 PGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQR :::: :::.:: ::::.:::::::::::.::::..:.:::. : . ... .:: :::. gi|739 PGDEGADGSGSASDWAAPLEDPLRSCCLAAADADKPQGAGGGSEGGAGGDGGSSGDSERP 180 190 200 210 220 230 240 250 260 270 280 KIAA06 GVGAG------GPEEGAPPATSAERTNGGA--EPRLGFSDIHFNSRNTFQVSRGQSARDH :.::: :: .: :..::: .::: ::: : :.. ::::::.::: :: gi|739 GAGAGAGGCEEGPSAAAAAAAGAERISGGAGAEPRPGVPDVRVNSRNTFEVSR-----DH 240 250 260 270 280 290 300 310 320 330 340 KIAA06 LPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFG ::::.:::: :::::: ::.:::::::::.::::.::::::::::::::::::::::::: gi|739 LPPASPPVPAPAAEQGAAGTSARARRSGGLADFFARNLFPKRTKELKSVVHSAPGWKLFG 290 300 310 320 330 340 350 360 370 380 390 400 KIAA06 KVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 KVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPA 350 360 370 380 390 400 410 420 430 440 450 460 KIAA06 KSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNW ::::::::::::::::::::::::::::.:::.::::::::::::::::::::::::::: gi|739 KSVEEALRHRQEYDEMVAEAKKREIKEAYKRKKIMKERFKQEENIASAMVIWINEILPNW 410 420 430 440 450 460 470 480 490 500 510 520 KIAA06 EVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 EVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSS 470 480 490 500 510 520 530 540 550 560 570 580 KIAA06 ENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYV ::: ::::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 ENDMEGVSLADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYV 530 540 550 560 570 580 590 600 610 620 630 640 KIAA06 QGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSK ::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::: gi|739 QGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHNMMLKYFATFEVFFEENLSK 590 600 610 620 630 640 650 660 670 680 690 700 KIAA06 LFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 LFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYE 650 660 670 680 690 700 710 720 730 740 750 760 KIAA06 DILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 DILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKN 710 720 730 740 750 760 770 KIAA06 SSPALKS .:::::: gi|739 NSPALKS 770 >>gi|109090045|ref|XP_001090278.1| PREDICTED: TBC1 domai (732 aa) initn: 4050 init1: 4050 opt: 4082 Z-score: 3991.1 bits: 749.2 E(): 1.3e-213 Smith-Waterman score: 4085; 87.587% identity (91.632% similar) in 717 aa overlap (65-775:26-732) 40 50 60 70 80 90 KIAA06 DRKVIRATGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAG----EQLEPGLCYCPL : :. : ....: ..: : : . : gi|109 MVRGISRLGLDRSDFCACASPGACPPSRNCLTPRVGGVGLGTLRRLSPRLQHSEL 10 20 30 40 50 100 110 120 130 140 KIAA06 PAGQAGAPPPSAAPRSDACL-LGSGSKHRGAEVADGRAPRHEGMTNGDSGFLP-GRDCRD ::: : :: : . : : . :: .:: :. . . : :.: . gi|109 FCGQACAWSPSLPPGAAATRPQMVGPEDAGA--CSGRNPKLLPVPAPE----PVGQDGK- 60 70 80 90 100 150 160 170 180 190 200 KIAA06 LEEARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAAD ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: gi|109 ---ARGLARAGGRESRRRRPCGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAAD 110 120 130 140 150 160 210 220 230 240 250 260 KIAA06 AQEPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSD :.::::::: ::::::.:::.:::::: ::::::::::.:::::::::.:::: :::::: gi|109 AEEPEGAGSGSGDSPANSCSGSEDSEQPGVGAGGPEEGSPPATSAERTSGGAESRLGFSD 170 180 190 200 210 220 270 280 290 300 310 320 KIAA06 IHFNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFP ::.::::::.::::.:: :::::::: ::::.:::::: . :::::::::::::.::::: gi|109 IHLNSRNTFEVSRGHSASDHLPPAGPSVPLPTAEQGPAETLARARRSGGFADFFARNLFP 230 240 250 260 270 280 330 340 350 360 370 380 KIAA06 KRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFE ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|109 KRTKELKSVVHSAPGWKLFGKVPPRENLQKTSRIIQQEYEARTGRTCKPPPQSSRRKNFE 290 300 310 320 330 340 390 400 410 420 430 440 KIAA06 FEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 FEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFK 350 360 370 380 390 400 450 460 470 480 490 500 KIAA06 QEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 QEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL 410 420 430 440 450 460 510 520 530 540 550 560 KIAA06 YEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 YEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYH 470 480 490 500 510 520 570 580 590 600 610 620 KIAA06 DVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 DVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDH 530 540 550 560 570 580 630 640 650 660 670 680 KIAA06 SMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF 590 600 610 620 630 640 690 700 710 720 730 740 KIAA06 CRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 CRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNST 650 660 670 680 690 700 750 760 770 KIAA06 KKWTQVFASVMKDIKEGDKNSSPALKS :::::::::::::::::.::::::::: gi|109 KKWTQVFASVMKDIKEGEKNSSPALKS 710 720 730 >>gi|126273232|ref|XP_001374921.1| PREDICTED: similar to (777 aa) initn: 3691 init1: 3209 opt: 3704 Z-score: 3621.3 bits: 680.8 E(): 5.2e-193 Smith-Waterman score: 3782; 75.743% identity (82.921% similar) in 808 aa overlap (7-775:1-777) 10 20 30 40 50 60 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADE :::::::::::::.:.:.: :.:.: :.: ..: :::: :: .:: :: .: gi|126 MVGPEDAGACSGRKPRLFPPPGPEPGGRDGRMIGATGGPGGCC--LEPQEEEEE 10 20 30 40 50 70 80 90 100 KIAA06 EEET---------------PPRQLLQRYLAAAGEQLEPGLCYC-PLPAGQAGAPPPSAAP ::: ::..:.:::::::: :::::::.: :: ..::: : : . gi|126 EEEESEEEESEEEEEGATPPPQRLIQRYLAAAGGQLEPGLCHCSPLTGSQAGLPLPPPGS 60 70 80 90 100 110 110 120 130 140 150 KIAA06 RSDACLLG--SGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEA---------R : :. .:. :. : .::: ::::::::: : :.::: . gi|126 GSRLCVDDEPDGKPPPGG----GPGPRHPRMTNGDSGFLLGPGCHDLEAGGLPLPSRPCT 120 130 140 150 160 160 170 180 190 200 KIAA06 GLARAG---------GRESRRRRPYGRLRLEGPGDEDADGAG-SPSDWASPLEDPLRSCC .:.. : .:: : : . :: :: :: : :::: :.::::::::: gi|126 SLVQEGDSGDSFHHFSREPRCCRSSSLRRL--PG---ADDRGESPSDGATPLEDPLRSCR 170 180 190 200 210 220 210 220 230 240 250 260 KIAA06 LVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGG--AE : :.:: .:.::: :::.. ::: ..: . ::: :: :: gi|126 L---GADEPMESGGDSG---------SEDAR---VGA--TQRG---EEAEERTLGGRPAE 230 240 250 260 270 280 290 300 310 320 KIAA06 PRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADF : . :.:...:::::..::: ::: :.: :: .: ::.: :::::.:.:::::::::: gi|126 PGFCFTDVNLNSRNTYEVSRRQSAPDYLAQAGLLLPPPASELGPAGAAAKARRSGGFADF 270 280 290 300 310 320 330 340 350 360 370 380 KIAA06 FTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQS ::::.::::::::::.:::::::::::::::::::::.::::::::::::::::::: : gi|126 FTRNFFPKRTKELKSAVHSAPGWKLFGKVPPRENLQKASKIIQQEYEARTGRTCKPPLPS 330 340 350 360 370 380 390 400 410 420 430 440 KIAA06 SRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKR .::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::. gi|126 TRRKNFEFEPLSTTALILEDRPSNLPAKSIEEALRHRQEYDEMVAEAKKREIKEAHKRKK 390 400 410 420 430 440 450 460 470 480 490 500 KIAA06 IMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNE :::::::::::::::::::.:::::::: ::::::::::::::::::::::::::::::: gi|126 IMKERFKQEENIASAMVIWVNEILPNWEGMRSTRRVRELWWQGLPPSVRGKVWSLAVGNE 450 460 470 480 490 500 510 520 530 540 550 560 KIAA06 LNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIF ::::::::::::::::::::::::::.::: ::::::::::::::::::::::::::::: gi|126 LNITPELYEIFLSRAKERWKSFSETSTENDIEGVSVADREASLELIKLDISRTFPSLYIF 510 520 530 540 550 560 570 580 590 600 610 620 KIAA06 QKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 QKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQL 570 580 590 600 610 620 630 640 650 660 670 680 KIAA06 AFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 AFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLA 630 640 650 660 670 680 690 700 710 720 730 740 KIAA06 CRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|126 CRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAA 690 700 710 720 730 740 750 760 770 KIAA06 IQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS ::::::::::::::::::::::::::: :::::: gi|126 IQMQNSTKKWTQVFASVMKDIKEGDKNHSPALKS 750 760 770 >>gi|194205839|ref|XP_001500836.2| PREDICTED: TBC1 domai (742 aa) initn: 3731 init1: 3313 opt: 3684 Z-score: 3602.0 bits: 677.2 E(): 6.2e-192 Smith-Waterman score: 3967; 83.967% identity (90.082% similar) in 736 aa overlap (54-775:24-742) 30 40 50 60 70 KIAA06 LPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADEEEETPP--RQL---LQRYLA--A ::: . .: : : : ..: : . gi|194 MTHVPNPRHGASRKLQLAPPHPPPPEMGAGLPHTGPGARPLAVTVSRSWADRT 10 20 30 40 50 80 90 100 110 120 130 KIAA06 AGEQL--EPGLCY---CPLPAGQAGAPPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHE ..: : :: :. : : .. :.. :: : . .::::.:: ::::: gi|194 SSEYLLSEPYPCFRKNCHARNGPTSLHHPDVNPRLAAKV------YRGAEAADTRAPRHG 60 70 80 90 100 140 150 160 170 180 190 KIAA06 GMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDW ::::::::::::.::.::::::::::::::: :.: :: ::::::: :::::: :.: gi|194 GMTNGDSGFLPGQDCHDLEEARGLARAGGREPRHR----RLCLEGPGDEGADGAGSRSNW 110 120 130 140 150 160 200 210 220 230 240 250 KIAA06 ASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPAT :. ::::::.:::.:::..::::::: ..: :.::: :: :.::: ::::: ::. gi|194 AQ-LEDPLRTCCLAAADTEEPEGAGS------GGSGSGSEDLEQPGAGAGRPEEGASPAA 170 180 190 200 210 260 270 280 290 300 KIAA06 SAERTNG--GAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGAS :::::.: ::::::::. .::::::.::: :::::::::::: .: ::.::::::.: gi|194 SAERTSGAAGAEPRLGFAGALLNSRNTFEVSRRQSARDHLPPAGPQAPSPAVEQGPAGTS 220 230 240 250 260 270 310 320 330 340 350 360 KIAA06 ARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEA .::::::::::::.:::: :::::.::::::::::::::::::::::::::::::::::: gi|194 TRARRSGGFADFFARNLFSKRTKEFKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEA 280 290 300 310 320 330 370 380 390 400 410 420 KIAA06 RTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAK :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: gi|194 RTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSMEEALRHRQEYDEMVAEAK 340 350 360 370 380 390 430 440 450 460 470 480 KIAA06 KREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSV :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: gi|194 KREIKEAHKRKKIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSV 400 410 420 430 440 450 490 500 510 520 530 540 KIAA06 RGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKL :::::::::::::::::::::::::::::::::::::.:::.:::::::::::::::::: gi|194 RGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETNSENNTEGVSVADREASLELIKL 460 470 480 490 500 510 550 560 570 580 590 600 KIAA06 DISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 DISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFI 520 530 540 550 560 570 610 620 630 640 650 660 KIAA06 AFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 AFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIF 580 590 600 610 620 630 670 680 690 700 710 720 KIAA06 TLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 TLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPED 640 650 660 670 680 690 730 740 750 760 770 KIAA06 ITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS ::::::::::::::::::::::::::.::::::::::::.:::::: gi|194 ITSEKLFSCIAAIQMQNSTKKWTQVFSSVMKDIKEGDKNNSPALKS 700 710 720 730 740 >>gi|73998064|ref|XP_859120.1| PREDICTED: similar to TBC (698 aa) initn: 3787 init1: 3200 opt: 3313 Z-score: 3239.8 bits: 610.1 E(): 9.4e-172 Smith-Waterman score: 4067; 82.452% identity (86.452% similar) in 775 aa overlap (7-775:1-698) 10 20 30 40 50 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPP---EE :::::::::::::::::::::: .::::: :.::::::::::::::::: :: gi|739 MVGPEDAGACSGRNPKLLPVPALEPVGQDGKMIRATGGFGGGVGAVEPPAEEEE 10 20 30 40 50 60 70 80 90 100 110 KIAA06 ADEEEETPPRQLLQRYLAAAGE-QLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSK .:::::::.:::.::::::: ::: .:: :. gi|739 EEEEEETPPQQLLRRYLAAAGGGQLESALC----------------------------SR 60 70 80 120 130 140 150 160 170 KIAA06 HRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEG : .:: :::::.:::::::::: :.: :::::::::::::::. ::: :: .: gi|739 ---AAAADVRAPRHRGMTNGDSGFLAGQDSRDLEEARGLARAGGRDPSRRR----LRPQG 90 100 110 120 130 180 190 200 210 220 230 KIAA06 PGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQR :::: :::.:: ::::.:::::::::::.::::..:.:: gi|739 PGDEGADGSGSASDWAAPLEDPLRSCCLAAADADKPQGA--------------------- 140 150 160 170 240 250 260 270 280 290 KIAA06 GVGAGGPEEGAPPATSAERTNGGA--EPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGP ::: .::: ::: : :.. ::::::.::: ::::::.: gi|739 ----------------AERISGGAGAEPRPGVPDVRVNSRNTFEVSR-----DHLPPASP 180 190 200 210 300 310 320 330 340 350 KIAA06 PVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRE ::: :::::: ::.:::::::::.::::.::::::::::::::::::::::::::::::: gi|739 PVPAPAAEQGAAGTSARARRSGGLADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPRE 220 230 240 250 260 270 360 370 380 390 400 410 KIAA06 NLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 NLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEA 280 290 300 310 320 330 420 430 440 450 460 470 KIAA06 LRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRST ::::::::::::::::::::::.:::.::::::::::::::::::::::::::::::::: gi|739 LRHRQEYDEMVAEAKKREIKEAYKRKKIMKERFKQEENIASAMVIWINEILPNWEVMRST 340 350 360 370 380 390 480 490 500 510 520 530 KIAA06 RRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: gi|739 RRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDMEG 400 410 420 430 440 450 540 550 560 570 580 590 KIAA06 VSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFI ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 VSLADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFI 460 470 480 490 500 510 600 610 620 630 640 650 KIAA06 AAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFK ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: gi|739 AAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHNMMLKYFATFEVFFEENLSKLFLHFK 520 530 540 550 560 570 660 670 680 690 700 710 KIAA06 SYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 SYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQM 580 590 600 610 620 630 720 730 740 750 760 770 KIAA06 DFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALK ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|739 DFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNNSPALK 640 650 660 670 680 690 KIAA06 S : gi|739 S >>gi|182701375|sp|Q6A039.2|TBC12_MOUSE RecName: Full=TBC (696 aa) initn: 3596 init1: 3253 opt: 3284 Z-score: 3211.4 bits: 604.8 E(): 3.5e-170 Smith-Waterman score: 3781; 78.283% identity (84.395% similar) in 769 aa overlap (7-775:1-696) 10 20 30 40 50 60 KIAA06 AATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPEEADE :.:::::::::::: .:::::. :.::: :.. ::.::.::. :.:::::: : gi|182 MMGPEDAGACSGRNAELLPVPG--PMGQDGKTVPATSGFSGGAVAAEPPEEAGE 10 20 30 40 50 70 80 90 100 110 120 KIAA06 EEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSKHRGA :: :::::::::::::. :.::: .:: :: .: gi|182 EEAPPPRQLLQRYLAAAAGPLKPGL---------GGAEAEEAA---------------AA 60 70 80 130 140 150 160 170 180 KIAA06 EVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGRLRLEGPGDE : : : :::::::::: .: : : .:.:::: :: : :.:: gi|182 AVP---AARGSGMTNGDSGFLLRQD-----------RRGPEEARRRRTCGRPCLLEPADE 90 100 110 120 130 190 200 210 220 230 240 KIAA06 DADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGA .::::. .:::.:::::::::::.:.:...:. ::. gi|182 GVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD---------PAA--------------- 140 150 160 170 250 260 270 280 290 300 KIAA06 GGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPA :: : :. .::: ::. : .:.:::::.::: ::: : :: ::: .:::: gi|182 ---------ATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPA 180 190 200 210 220 310 320 330 340 350 360 KIAA06 AEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTS :::::.:..:::::::::::::.::::::::::::::::::::::::::::::::::::: gi|182 AEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTS 230 240 250 260 270 280 370 380 390 400 410 420 KIAA06 KIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQE :::::::::::::::: :::::::.: .:::::::::::::: :::::::::::::::: gi|182 KIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAKSVEEALRHRQE 290 300 310 320 330 340 430 440 450 460 470 480 KIAA06 YDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVREL :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: gi|182 YDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWEVMRSTRRVREL 350 360 370 380 390 400 490 500 510 520 530 540 KIAA06 WWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADR :::::::::::::::::::::::::::::::::::::::::::::.::::::::.::::: gi|182 WWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSENDTEGLSVADR 410 420 430 440 450 460 550 560 570 580 590 600 KIAA06 EASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 EASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLIL 470 480 490 500 510 520 610 620 630 640 650 660 KIAA06 NLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|182 NLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYNLTP 530 540 550 560 570 580 670 680 690 700 710 720 KIAA06 DIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 DIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIA 590 600 610 620 630 640 730 740 750 760 770 KIAA06 QFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS :::::::::::::::::::::::::::::::::::::: :::::::::.:::::: gi|182 QFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNTSPALKS 650 660 670 680 690 >>gi|148709865|gb|EDL41811.1| TBC1D12: TBC1 domain famil (599 aa) initn: 3324 init1: 3253 opt: 3278 Z-score: 3206.4 bits: 603.7 E(): 6.7e-170 Smith-Waterman score: 3453; 83.515% identity (88.647% similar) in 643 aa overlap (133-775:1-599) 110 120 130 140 150 160 KIAA06 APRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRE ::::::::: .: : : .: gi|148 MTNGDSGFLLRQD-----------RRGPEE 10 170 180 190 200 210 220 KIAA06 SRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGDS .:::: :: : :.:: .::::. .:::.:::::::::::.:.:...:. gi|148 ARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD--------- 20 30 40 50 60 70 230 240 250 260 270 280 KIAA06 PASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSRG ::. :: : :. .::: ::. : .:.:::::.::: gi|148 PAA------------------------ATPAGRAVESAEPSLGLPDARFGSRNTFEVSRR 80 90 100 290 300 310 320 330 340 KIAA06 QSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAP ::: : :: ::: .:::::::::.:..:::::::::::::.::::::::::::::::::: gi|148 QSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAP 110 120 130 140 150 160 350 360 370 380 390 400 KIAA06 GWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDR :::::::::::::::::::::::::::::::::: :::::::.: .::::::::::::: gi|148 GWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDR 170 180 190 200 210 220 410 420 430 440 450 460 KIAA06 PSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWIN : :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: gi|148 PPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWIN 230 240 250 260 270 280 470 480 490 500 510 520 KIAA06 EILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 EILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKS 290 300 310 320 330 340 530 540 550 560 570 580 KIAA06 FSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYR :::.::::::::.::::::::::::::::::::::::::::::::::::::::::::::: gi|148 FSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYR 350 360 370 380 390 400 590 600 610 620 630 640 KIAA06 PDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 PDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFF 410 420 430 440 450 460 650 660 670 680 690 700 KIAA06 EENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLG ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: gi|148 EENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLG 470 480 490 500 510 520 710 720 730 740 750 760 KIAA06 ILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: gi|148 ILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDI 530 540 550 560 570 580 770 KIAA06 KEGDKNSSPALKS ::::::.:::::: gi|148 KEGDKNTSPALKS 590 775 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Thu Mar 5 09:33:10 2009 done: Thu Mar 5 09:37:00 2009 Total Scan time: 1611.040 Total Display time: 0.450 Function used was FASTA [version 34.26.5 April 26, 2007]