hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080909/iprscan-20080909-09370164/chunk_1/iprscan-20080909-09370164.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA0302 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00435.11.ls Spectrin repeat 1264.5 0 17 PF00435.11.fs Spectrin repeat 1257.0 0 17 PF00307.21.ls Calponin homology (CH) domain 261.6 1.5e-75 2 PF00307.21.fs Calponin homology (CH) domain 257.8 2e-74 2 PF00169.19.fs PH domain 61.3 3.3e-18 1 PF00169.19.ls PH domain 63.4 7e-16 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00307.21.fs 1/2 82 185 .. 1 122 [] 119.7 7.6e-33 PF00307.21.ls 1/2 82 185 .. 1 122 [] 121.6 2.1e-33 PF00307.21.fs 2/2 201 305 .. 1 122 [] 138.1 2.2e-38 PF00307.21.ls 2/2 201 305 .. 1 122 [] 140.0 5.9e-39 PF00435.11.ls 1/17 329 439 .. 1 111 [] 65.6 1.5e-16 PF00435.11.fs 1/17 329 439 .. 1 111 [] 63.6 2.1e-18 PF00435.11.ls 2/17 449 553 .. 1 111 [] 89.7 8.1e-24 PF00435.11.fs 2/17 449 553 .. 1 111 [] 87.8 1.3e-25 PF00435.11.ls 3/17 555 663 .. 1 111 [] 86.1 1e-22 PF00435.11.fs 3/17 555 663 .. 1 111 [] 84.1 1.7e-24 PF00435.11.ls 4/17 665 769 .. 1 111 [] 80.1 6.3e-21 PF00435.11.fs 4/17 665 769 .. 1 111 [] 78.2 9.5e-23 PF00435.11.fs 5/17 771 874 .. 1 111 [] 82.2 6.1e-24 PF00435.11.ls 5/17 771 874 .. 1 111 [] 84.1 3.9e-22 PF00435.11.fs 6/17 876 980 .. 1 111 [] 77.3 1.8e-22 PF00435.11.ls 6/17 876 980 .. 1 111 [] 79.2 1.2e-20 PF00435.11.ls 7/17 982 1087 .. 1 111 [] 84.6 2.9e-22 PF00435.11.fs 7/17 982 1087 .. 1 111 [] 82.6 4.6e-24 PF00435.11.fs 8/17 1089 1194 .. 1 111 [] 63.0 3.3e-18 PF00435.11.ls 8/17 1089 1194 .. 1 111 [] 64.9 2.4e-16 PF00435.11.fs 9/17 1196 1283 .. 1 94 [. 35.8 3.9e-10 PF00435.11.ls 9/17 1196 1300 .. 1 111 [] 36.3 9.7e-08 PF00435.11.ls 10/17 1302 1405 .. 1 111 [] 86.2 9.2e-23 PF00435.11.fs 10/17 1302 1405 .. 1 111 [] 84.3 1.5e-24 PF00435.11.ls 11/17 1407 1510 .. 1 111 [] 78.6 1.8e-20 PF00435.11.fs 11/17 1407 1510 .. 1 111 [] 76.7 2.6e-22 PF00435.11.ls 12/17 1512 1610 .. 1 111 [] 86.9 5.6e-23 PF00435.11.fs 12/17 1512 1610 .. 1 111 [] 85.1 8.6e-25 PF00435.11.fs 13/17 1612 1716 .. 1 111 [] 89.5 4.1e-26 PF00435.11.ls 13/17 1612 1716 .. 1 111 [] 91.4 2.5e-24 PF00435.11.ls 14/17 1718 1823 .. 1 111 [] 91.3 2.7e-24 PF00435.11.fs 14/17 1718 1823 .. 1 111 [] 89.4 4.6e-26 PF00435.11.fs 15/17 1825 1929 .. 1 111 [] 75.0 8.4e-22 PF00435.11.ls 15/17 1825 1929 .. 1 111 [] 77.0 5.6e-20 PF00435.11.fs 16/17 1931 2035 .. 1 111 [] 65.9 4.3e-19 PF00435.11.ls 16/17 1931 2035 .. 1 111 [] 67.8 3.1e-17 PF00435.11.fs 17/17 2037 2099 .. 1 68 [. 36.3 2.8e-10 PF00435.11.ls 17/17 2037 2115 .. 1 111 [] 14.4 0.0026 PF00169.19.fs 1/1 2243 2352 .. 1 92 [] 61.3 3.3e-18 PF00169.19.ls 1/1 2243 2352 .. 1 92 [] 63.4 7e-16 Alignments of top-scoring domains: PF00307.21.fs: domain 1 of 2, from 82 to 185: score 119.7, E = 7.6e-33 *->sqekellrWvnsvlagypgnkdtlPippvritnfftdwlkDGlaLca +q+k++++Wvns+la + +r+ ++++d++ DG+ L+ KIAA0302 82 VQKKTFTKWVNSHLAR-VT---------CRVGDLYSDLR-DGRNLLR 117 LlnklrPglidkkkvpslsrfdkleNlnlaldaaekeGlgiilvlidpeD Ll++l+++ ++k ++++r+++leN+ +al++++++ ++ l++++++D KIAA0302 118 LLEVLSGEILPKPT-KGRMRIHCLENVDKALQFLKEQ-KVH-LENMGSHD 164 ivegnpdPDeklvltllwqLirrfq<-* iv+gn +l+l+l+w++i+rfq KIAA0302 165 IVDGNH----RLTLGLVWTIILRFQ 185 PF00307.21.ls: domain 1 of 2, from 82 to 185: score 121.6, E = 2.1e-33 *->sqekellrWvnsvlagypgnkdtlPippvritnfftdwlkDGlaLca +q+k++++Wvns+la + +r+ ++++d++ DG+ L+ KIAA0302 82 VQKKTFTKWVNSHLAR-VT---------CRVGDLYSDLR-DGRNLLR 117 LlnklrPglidkkkvpslsrfdkleNlnlaldaaekeGlgiilvlidpeD Ll++l+++ ++k ++++r+++leN+ +al++++++ ++ l++++++D KIAA0302 118 LLEVLSGEILPKPT-KGRMRIHCLENVDKALQFLKEQ-KVH-LENMGSHD 164 ivegnpdPDeklvltllwqLirrfq<-* iv+gn +l+l+l+w++i+rfq KIAA0302 165 IVDGNH----RLTLGLVWTIILRFQ 185 PF00307.21.fs: domain 2 of 2, from 201 to 305: score 138.1, E = 2.2e-38 *->sqekellrWvnsvlagypgnkdtlPippvritnfftdwlkDGlaLca s++++ll W+++++agyp+ v++ nf+t+w+ DGla++a KIAA0302 201 SAKDALLLWCQMKTAGYPN---------VNVHNFTTSWR-DGLAFNA 237 LlnklrPglidkkkvpslsrfdkleNlnlaldaaekeGlgiilvlidpeD +++k+rP+l+d++ sl + ++ Nl++a+++aeke lg ++l+dpeD KIAA0302 238 IVHKHRPDLLDFE---SLKKCNAHYNLQNAFNLAEKE-LGL-TKLLDPED 282 ivegnpdPDeklvltllwqLirrfq<-* + +++ PDek+++t++++++++f+ KIAA0302 283 VN-VDQ-PDEKSIITYVATYYHYFS 305 PF00307.21.ls: domain 2 of 2, from 201 to 305: score 140.0, E = 5.9e-39 *->sqekellrWvnsvlagypgnkdtlPippvritnfftdwlkDGlaLca s++++ll W+++++agyp+ v++ nf+t+w+ DGla++a KIAA0302 201 SAKDALLLWCQMKTAGYPN---------VNVHNFTTSWR-DGLAFNA 237 LlnklrPglidkkkvpslsrfdkleNlnlaldaaekeGlgiilvlidpeD +++k+rP+l+d++ sl + ++ Nl++a+++aeke lg ++l+dpeD KIAA0302 238 IVHKHRPDLLDFE---SLKKCNAHYNLQNAFNLAEKE-LGL-TKLLDPED 282 ivegnpdPDeklvltllwqLirrfq<-* + +++ PDek+++t++++++++f+ KIAA0302 283 VN-VDQ-PDEKSIITYVATYYHYFS 305 PF00435.11.ls: domain 1 of 17, from 329 to 439: score 65.6, E = 1.5e-16 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH l +++ + a++l++Wie++ L++ + +++l++vq+ l+ ++ + KIAA0302 329 RLVEKYESLASELLQWIEQTIVTLNDRQL-ANSLSGVQNQLQSFnSY 374 kaleaelaa.hqdrvealninelaekLiideghyaseeiqerleeLnerW ++ e+ ++++++e l ++++ kL++++++ +++ ++++n++W KIAA0302 375 RTVEKPPKFtEKGNLEVLL-FTIQSKLRANNQKVYTPREGRLISDINKAW 423 eqLlelaaeRkqkLee<-* e+L+++ eR+ +L+ KIAA0302 424 ERLEKAEHERELALRT 439 PF00435.11.fs: domain 1 of 17, from 329 to 439: score 63.6, E = 2.1e-18 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH l +++ + a++l++Wie++ L++ + +++l++vq+ l+ ++ + KIAA0302 329 RLVEKYESLASELLQWIEQTIVTLNDRQL-ANSLSGVQNQLQSFnSY 374 kaleaelaa.hqdrvealninelaekLiideghyaseeiqerleeLnerW ++ e+ ++++++e l ++++ kL++++++ +++ ++++n++W KIAA0302 375 RTVEKPPKFtEKGNLEVLL-FTIQSKLRANNQKVYTPREGRLISDINKAW 423 eqLlelaaeRkqkLee<-* e+L+++ eR+ +L+ KIAA0302 424 ERLEKAEHERELALRT 439 PF00435.11.ls: domain 2 of 17, from 449 to 553: score 89.7, E = 8.1e-24 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +l+ +F r+a+ e W++e +l+s++++ g l++v+a + kH+ KIAA0302 449 QLAARFDRKAAMRETWLSENQRLVSQDNF-GLELAAVEAAVR--KHE 492 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+e ++ a+ +rv+a++ ++a++L ++e +++ ++i +r+ ++ ++W+ KIAA0302 493 AIETDIVAYSGRVQAVD--AVAAEL-AAERYHDIKRIAARQHNVARLWDF 539 LlelaaeRkqkLee<-* L++++a+R+++L+ KIAA0302 540 LRQMVAARRERLLL 553 PF00435.11.fs: domain 2 of 17, from 449 to 553: score 87.8, E = 1.3e-25 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +l+ +F r+a+ e W++e +l+s++++ g l++v+a + kH+ KIAA0302 449 QLAARFDRKAAMRETWLSENQRLVSQDNF-GLELAAVEAAVR--KHE 492 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+e ++ a+ +rv+a++ ++a++L ++e +++ ++i +r+ ++ ++W+ KIAA0302 493 AIETDIVAYSGRVQAVD--AVAAEL-AAERYHDIKRIAARQHNVARLWDF 539 LlelaaeRkqkLee<-* L++++a+R+++L+ KIAA0302 540 LRQMVAARRERLLL 553 PF00435.11.ls: domain 3 of 17, from 555 to 663: score 86.1, E = 1e-22 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+lq+ ++d+ l+ W+ee++ L+s+d+ g++l++v+ Ll+ H+ KIAA0302 555 LELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQ--LHE 598 aleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLner + ea++a++ +rv+a+ + a ++ +++ ++ +++ ++er++ L++ KIAA0302 599 LVEADIAVQAERVRAVS--ASALRFCNPGKeyrPCDPQLVSERVAKLEQS 646 WeqLlelaaeRkqkLee<-* +e+L+elaa+R+++Lee KIAA0302 647 YEALCELAAARRARLEE 663 PF00435.11.fs: domain 3 of 17, from 555 to 663: score 84.1, E = 1.7e-24 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+lq+ ++d+ l+ W+ee++ L+s+d+ g++l++v+ Ll+ H+ KIAA0302 555 LELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQ--LHE 598 aleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLner + ea++a++ +rv+a+ + a ++ +++ ++ +++ ++er++ L++ KIAA0302 599 LVEADIAVQAERVRAVS--ASALRFCNPGKeyrPCDPQLVSERVAKLEQS 646 WeqLlelaaeRkqkLee<-* +e+L+elaa+R+++Lee KIAA0302 647 YEALCELAAARRARLEE 663 PF00435.11.ls: domain 4 of 17, from 665 to 769: score 80.1, E = 6.3e-21 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +l++F++++ ++e+W +e+ lL+s d g+dl+++ Ll kH KIAA0302 665 RRLWRFLWEVGEAEAWVREQQHLLASADT-GRDLTGALRLLN--KHT 708 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq al+ e++++ + ++ e++++L ++egh+ + + ++r +eL ++We+ KIAA0302 709 ALRGEMSGRLGPLKLTL--EQGQQL-VAEGHPGASQASARAAELQAQWER 755 LlelaaeRkqkLee<-* L++la+eR q+L + KIAA0302 756 LEALAEERAQRLAQ 769 PF00435.11.fs: domain 4 of 17, from 665 to 769: score 78.2, E = 9.5e-23 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +l++F++++ ++e+W +e+ lL+s d g+dl+++ Ll kH KIAA0302 665 RRLWRFLWEVGEAEAWVREQQHLLASADT-GRDLTGALRLLN--KHT 708 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq al+ e++++ + ++ e++++L ++egh+ + + ++r +eL ++We+ KIAA0302 709 ALRGEMSGRLGPLKLTL--EQGQQL-VAEGHPGASQASARAAELQAQWER 755 LlelaaeRkqkLee<-* L++la+eR q+L + KIAA0302 756 LEALAEERAQRLAQ 769 PF00435.11.fs: domain 5 of 17, from 771 to 874: score 82.2, E = 6.1e-24 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+qFq da+d+e+W+ ++ +l+ss+++ g+d+ ++qaL + +H+ KIAA0302 771 ASLYQFQADANDMEAWLVDALRLVSSPEL-GHDEFSTQALAR--QHR 814 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq ale+e+ h++ ++al e+a++L ++e+q r+ L++++e+ KIAA0302 815 ALEEEIRSHRPTLDALR--EQAAAL--PPTLSRTPEVQGRVPTLERHYEE 860 LlelaaeRkqkLee<-* L+++a eR ++Le+ KIAA0302 861 LQARAGERARALEA 874 PF00435.11.ls: domain 5 of 17, from 771 to 874: score 84.1, E = 3.9e-22 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+qFq da+d+e+W+ ++ +l+ss+++ g+d+ ++qaL + +H+ KIAA0302 771 ASLYQFQADANDMEAWLVDALRLVSSPEL-GHDEFSTQALAR--QHR 814 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq ale+e+ h++ ++al e+a++L ++e+q r+ L++++e+ KIAA0302 815 ALEEEIRSHRPTLDALR--EQAAAL--PPTLSRTPEVQGRVPTLERHYEE 860 LlelaaeRkqkLee<-* L+++a eR ++Le+ KIAA0302 861 LQARAGERARALEA 874 PF00435.11.fs: domain 6 of 17, from 876 to 980: score 77.3, E = 1.8e-22 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l l+ ++++a +W eeke++L+ + ++ le++++ ++ +++ KIAA0302 876 LALYTMLSEAGACGLWVEEKEQWLNGLAL-PERLEDLEVVQQ--RFE 919 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +le e++ + ++ a+n ++ae+L + ++++ ++i ++e+Ln+rW+q KIAA0302 920 TLEPEMNTLAAQITAVN--DIAEQL-LKANPPGKDRIVNTQEQLNHRWQQ 966 LlelaaeRkqkLee<-* ++la+ +k++L KIAA0302 967 FRRLADGKKAALTS 980 PF00435.11.ls: domain 6 of 17, from 876 to 980: score 79.2, E = 1.2e-20 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l l+ ++++a +W eeke++L+ + ++ le++++ ++ +++ KIAA0302 876 LALYTMLSEAGACGLWVEEKEQWLNGLAL-PERLEDLEVVQQ--RFE 919 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +le e++ + ++ a+n ++ae+L + ++++ ++i ++e+Ln+rW+q KIAA0302 920 TLEPEMNTLAAQITAVN--DIAEQL-LKANPPGKDRIVNTQEQLNHRWQQ 966 LlelaaeRkqkLee<-* ++la+ +k++L KIAA0302 967 FRRLADGKKAALTS 980 PF00435.11.ls: domain 7 of 17, from 982 to 1087: score 84.6, E = 2.9e-22 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH l +q ++ ++ + ++W++ek ++++s++ + g+dl++v aL++ k+ KIAA0302 982 LSIQNYHLECTETQAWMREKTKVIeSTQGL-GNDLAGVLALQR--KL 1025 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe + e++l+a rv +l+ +a++L +++++ ++ +i +rl e+ + We KIAA0302 1026 AGTERDLEAIAARVGELT--REANAL-AAGHPAQAVAINARLREVQTGWE 1072 qLlelaaeRkqkLee<-* +L++ + +R++ L e KIAA0302 1073 DLRATMRRREESLGE 1087 PF00435.11.fs: domain 7 of 17, from 982 to 1087: score 82.6, E = 4.6e-24 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH l +q ++ ++ + ++W++ek ++++s++ + g+dl++v aL++ k+ KIAA0302 982 LSIQNYHLECTETQAWMREKTKVIeSTQGL-GNDLAGVLALQR--KL 1025 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe + e++l+a rv +l+ +a++L +++++ ++ +i +rl e+ + We KIAA0302 1026 AGTERDLEAIAARVGELT--REANAL-AAGHPAQAVAINARLREVQTGWE 1072 qLlelaaeRkqkLee<-* +L++ + +R++ L e KIAA0302 1073 DLRATMRRREESLGE 1087 PF00435.11.fs: domain 8 of 17, from 1089 to 1194: score 63.0, E = 3.3e-18 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +lq F+r +dd+++W+ + + ++se+ + +l e++aLl +H KIAA0302 1089 RRLQDFLRSLDDFQAWLGRTQTAVASEEG-PATLPEAEALLA--QHA 1132 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq al+ e++ q l +l+e++ d+ +++ +++rle+L + We+ KIAA0302 1133 ALRGEVERAQSEYSRLR--ALGEEVTRDQADPQCLFLRQRLEALGTGWEE 1180 LlelaaeRkqkLee<-* L +++++R+ +L + KIAA0302 1181 LGRMWESRQGRLAQ 1194 PF00435.11.ls: domain 8 of 17, from 1089 to 1194: score 64.9, E = 2.4e-16 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +lq F+r +dd+++W+ + + ++se+ + +l e++aLl +H KIAA0302 1089 RRLQDFLRSLDDFQAWLGRTQTAVASEEG-PATLPEAEALLA--QHA 1132 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq al+ e++ q l +l+e++ d+ +++ +++rle+L + We+ KIAA0302 1133 ALRGEVERAQSEYSRLR--ALGEEVTRDQADPQCLFLRQRLEALGTGWEE 1180 LlelaaeRkqkLee<-* L +++++R+ +L + KIAA0302 1181 LGRMWESRQGRLAQ 1194 PF00435.11.fs: domain 9 of 17, from 1196 to 1283: score 35.8, E = 3.9e-10 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk + +q F+rda+++e ++ +e +Ls +++ + +l+++ a k k++ KIAA0302 1196 HGFQGFLRDARQAEGVLSSQEYVLSHTEM-PGTLQAADAAIK--KLE 1239 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLner<-* +++ ++a+ +r+ l e +++L ++eg ++ i+e+ + +++r KIAA0302 1240 DFMSTMDANGERIHGLL--EAGRQL-VSEGNIHADKIREKADSIERR 1283 PF00435.11.ls: domain 9 of 17, from 1196 to 1300: score 36.3, E = 9.7e-08 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk + +q F+rda+++e ++ +e +Ls +++ + +l+++ a k k++ KIAA0302 1196 HGFQGFLRDARQAEGVLSSQEYVLSHTEM-PGTLQAADAAIK--KLE 1239 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +++ ++a+ +r+ l e +++L ++eg ++ i+e+ + +++r ++ KIAA0302 1240 DFMSTMDANGERIHGLL--EAGRQL-VSEGNIHADKIREKADSIERRHKK 1286 LlelaaeRkqkLee<-* +++a++ +L++ KIAA0302 1287 NQDAAQQFLGRLRD 1300 PF00435.11.ls: domain 10 of 17, from 1302 to 1405: score 86.2, E = 9.2e-23 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH ++q F++d+ +l++Wi+ek +L+++d+ +++e+++L+ +++kH KIAA0302 1302 REQQHFLQDCHELKLWIDEK--MLTAQDV---SYDEARNLHTKWqKH 1343 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe +a++aelaa++d++++++ +++++L + e+++ ++e+l +L++rW+ KIAA0302 1344 QAFMAELAANKDWLDKVD--KEGREL-TLEKPELKALVSEKLRDLHRRWD 1390 qLlelaaeRkqkLee<-* +L++ ++++ + L + KIAA0302 1391 ELETTTQAKARSLFD 1405 PF00435.11.fs: domain 10 of 17, from 1302 to 1405: score 84.3, E = 1.5e-24 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH ++q F++d+ +l++Wi+ek +L+++d+ +++e+++L+ +++kH KIAA0302 1302 REQQHFLQDCHELKLWIDEK--MLTAQDV---SYDEARNLHTKWqKH 1343 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe +a++aelaa++d++++++ +++++L + e+++ ++e+l +L++rW+ KIAA0302 1344 QAFMAELAANKDWLDKVD--KEGREL-TLEKPELKALVSEKLRDLHRRWD 1390 qLlelaaeRkqkLee<-* +L++ ++++ + L + KIAA0302 1391 ELETTTQAKARSLFD 1405 PF00435.11.ls: domain 11 of 17, from 1407 to 1510: score 78.6, E = 1.8e-20 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +++++F++ + lesW+e a+L s+dy gkdl++v Llk k++ KIAA0302 1407 NRAELFAQSCCALESWLESLQAQLHSDDY-GKDLTSVNILLK--KQQ 1450 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq le e+a+++ vea++ ++a++L +++++ + e++ + +++e++ + KIAA0302 1451 MLEWEMAVREKEVEAIQ--AQAKAL--AQEDQGAGEVERTSRAVEEKFRA 1496 LlelaaeRkqkLee<-* L++ + eR ++L++ KIAA0302 1497 LCQPMRERCRRLQA 1510 PF00435.11.fs: domain 11 of 17, from 1407 to 1510: score 76.7, E = 2.6e-22 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +++++F++ + lesW+e a+L s+dy gkdl++v Llk k++ KIAA0302 1407 NRAELFAQSCCALESWLESLQAQLHSDDY-GKDLTSVNILLK--KQQ 1450 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq le e+a+++ vea++ ++a++L +++++ + e++ + +++e++ + KIAA0302 1451 MLEWEMAVREKEVEAIQ--AQAKAL--AQEDQGAGEVERTSRAVEEKFRA 1496 LlelaaeRkqkLee<-* L++ + eR ++L++ KIAA0302 1497 LCQPMRERCRRLQA 1510 PF00435.11.ls: domain 12 of 17, from 1512 to 1610: score 86.9, E = 5.6e-23 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +++qF+rd++d+ +W +e +++ss+++ gkdl +vq L+k k + KIAA0302 1512 REQHQFHRDVEDEILWVTERLPMASSMEH-GKDLPSVQLLMK--KNQ 1555 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +l++e+++h++r+ +l e +++L ++ + l+eL e W++ KIAA0302 1556 TLQKEIQGHEPRIADLR--ERQRAL-GAA------AAGPELAELQEMWKR 1596 LlelaaeRkqkLee<-* L ++ R ++Le+ KIAA0302 1597 LGHELELRGKRLED 1610 PF00435.11.fs: domain 12 of 17, from 1512 to 1610: score 85.1, E = 8.6e-25 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +++qF+rd++d+ +W +e +++ss+++ gkdl +vq L+k k + KIAA0302 1512 REQHQFHRDVEDEILWVTERLPMASSMEH-GKDLPSVQLLMK--KNQ 1555 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +l++e+++h++r+ +l e +++L ++ + l+eL e W++ KIAA0302 1556 TLQKEIQGHEPRIADLR--ERQRAL-GAA------AAGPELAELQEMWKR 1596 LlelaaeRkqkLee<-* L ++ R ++Le+ KIAA0302 1597 LGHELELRGKRLED 1610 PF00435.11.fs: domain 13 of 17, from 1612 to 1716: score 89.5, E = 4.1e-26 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l++qqF+rda+++e+W+ e+e +++ +++ +kd+ ++qa k kH+ KIAA0302 1612 LRAQQFYRDAAEAEAWMGEQELHMMGQEK-AKDELSAQAEVK--KHQ 1655 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq le la++ + +l + +++ id++h++s +i+ r+++++++++ KIAA0302 1656 VLEQALADYAQTIHQLA--ASSQDM-IDHEHPESTRISIRQAQVDKLYAG 1702 LlelaaeRkqkLee<-* L+ela eR+++L+e KIAA0302 1703 LKELAGERRERLQE 1716 PF00435.11.ls: domain 13 of 17, from 1612 to 1716: score 91.4, E = 2.5e-24 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l++qqF+rda+++e+W+ e+e +++ +++ +kd+ ++qa k kH+ KIAA0302 1612 LRAQQFYRDAAEAEAWMGEQELHMMGQEK-AKDELSAQAEVK--KHQ 1655 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq le la++ + +l + +++ id++h++s +i+ r+++++++++ KIAA0302 1656 VLEQALADYAQTIHQLA--ASSQDM-IDHEHPESTRISIRQAQVDKLYAG 1702 LlelaaeRkqkLee<-* L+ela eR+++L+e KIAA0302 1703 LKELAGERRERLQE 1716 PF00435.11.ls: domain 14 of 17, from 1718 to 1823: score 91.3, E = 2.7e-24 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+l q+ r++ddle+Wi+e e +++s ++ g+d+e+v L + k++ KIAA0302 1718 LRLCQLRRELDDLEQWIQEREVVAASHEL-GQDYEHVTMLRD--KFR 1761 aleaelaa.hqdrvealninelaekLiideghyaseeiqerleeLnerWe ++ ++ + q+rv++ n +la+ L i++gh a + e+++ Lne+W+ KIAA0302 1762 EFSRDTSTiGQERVDSAN--ALANGL-IAGGHAARATVAEWKDSLNEAWA 1808 qLlelaaeRkqkLee<-* +Llel+++R q L + KIAA0302 1809 DLLELLDTRGQVLAA 1823 PF00435.11.fs: domain 14 of 17, from 1718 to 1823: score 89.4, E = 4.6e-26 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+l q+ r++ddle+Wi+e e +++s ++ g+d+e+v L + k++ KIAA0302 1718 LRLCQLRRELDDLEQWIQEREVVAASHEL-GQDYEHVTMLRD--KFR 1761 aleaelaa.hqdrvealninelaekLiideghyaseeiqerleeLnerWe ++ ++ + q+rv++ n +la+ L i++gh a + e+++ Lne+W+ KIAA0302 1762 EFSRDTSTiGQERVDSAN--ALANGL-IAGGHAARATVAEWKDSLNEAWA 1808 qLlelaaeRkqkLee<-* +Llel+++R q L + KIAA0302 1809 DLLELLDTRGQVLAA 1823 PF00435.11.fs: domain 15 of 17, from 1825 to 1929: score 75.0, E = 8.4e-22 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk ++lq+F++ a+++++ + k ++L + g+dl +++aL++ +H KIAA0302 1825 YELQRFLHGARQALARVQHKQQQL-PDGT-GRDLNAAEALQR--RHC 1867 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+e++++a+ ++v++++ + + +L+ ++ ++ +eei ++++ e+W+q KIAA0302 1868 AYEHDIQALSPQVQQVQ--DDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1915 LlelaaeRkqkLee<-* L+ a+R+q L++ KIAA0302 1916 LQGSSAARRQLLLD 1929 PF00435.11.ls: domain 15 of 17, from 1825 to 1929: score 77.0, E = 5.6e-20 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk ++lq+F++ a+++++ + k ++L + g+dl +++aL++ +H KIAA0302 1825 YELQRFLHGARQALARVQHKQQQL-PDGT-GRDLNAAEALQR--RHC 1867 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+e++++a+ ++v++++ + + +L+ ++ ++ +eei ++++ e+W+q KIAA0302 1868 AYEHDIQALSPQVQQVQ--DDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQ 1915 LlelaaeRkqkLee<-* L+ a+R+q L++ KIAA0302 1916 LQGSSAARRQLLLD 1929 PF00435.11.fs: domain 16 of 17, from 1931 to 2035: score 65.9, E = 4.3e-19 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk + ++F++ +++l++W++e ++ ++++ ++d++++ k ++ KIAA0302 1931 TDKFRFFKAVRELMLWMDEVNLQMDAQER-PRDVSSADLVIK--NQQ 1974 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +++ae++a+ dr+ ++ +++++L ++++hya+eei+e+l++L +r+++ KIAA0302 1975 GIKAEIEARADRFSSCI--DMGKEL-LARSHYAAEEISEKLSQLQARRQE 2021 LlelaaeRkqkLee<-* e ++e+ +L+ KIAA0302 2022 TAEKWQEKMDWLQL 2035 PF00435.11.ls: domain 16 of 17, from 1931 to 2035: score 67.8, E = 3.1e-17 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk + ++F++ +++l++W++e ++ ++++ ++d++++ k ++ KIAA0302 1931 TDKFRFFKAVRELMLWMDEVNLQMDAQER-PRDVSSADLVIK--NQQ 1974 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +++ae++a+ dr+ ++ +++++L ++++hya+eei+e+l++L +r+++ KIAA0302 1975 GIKAEIEARADRFSSCI--DMGKEL-LARSHYAAEEISEKLSQLQARRQE 2021 LlelaaeRkqkLee<-* e ++e+ +L+ KIAA0302 2022 TAEKWQEKMDWLQL 2035 PF00435.11.fs: domain 17 of 17, from 2037 to 2099: score 36.3, E = 2.8e-10 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+ F rda +e+W+ +e+l+ s ++ g +++ev++L k +H+ KIAA0302 2037 LEVLVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIK--RHE 2080 aleaelaahqdrvealninel<-* a+++ a+++r+ al+ +l KIAA0302 2081 AFQKSAVAWEERFCALE--KL 2099 PF00435.11.ls: domain 17 of 17, from 2037 to 2115: score 14.4, E = 0.0026 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+ F rda +e+W+ +e+l+ s ++ g +++ev++L k +H+ KIAA0302 2037 LEVLVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIK--RHE 2080 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+++ a+++r+ al+ kL + + KIAA0302 2081 AFQKSAVAWEERFCALE------KL-T----------------------A 2101 LlelaaeRkqkLee<-* L+e+ +eRk+k ee KIAA0302 2102 LEEREKERKRKREE 2115 PF00169.19.fs: domain 1 of 1, from 2243 to 2352: score 61.3, E = 3.3e-18 *->vikeGwLlkkg.........gkkswkkRyfvLfddvLlyykdkk... +eG L +k + + +++ +++sw+ +y+vL++++L +ykd k + KIAA0302 2243 EQMEGMLCRKQemeafgkkaANRSWQNVYCVLRRGSLGFYKDAKaas 2289 ..kkpkgsipLsgiqvtkvpdn...krkncFeirt.dretlllqaeseee + + g +p+s ++ ++ + +krk++F++ +d++++l+qa++e e KIAA0302 2290 agVPYHGEVPVSLARAQGSVAFdyrKRKHVFKLGLqDGKEYLFQAKDEAE 2339 rkeWvkaiqsair<-* + +W++ + ai+ KIAA0302 2340 MSSWLRVVNAAIA 2352 PF00169.19.ls: domain 1 of 1, from 2243 to 2352: score 63.4, E = 7e-16 *->vikeGwLlkkg.........gkkswkkRyfvLfddvLlyykdkk... +eG L +k + + +++ +++sw+ +y+vL++++L +ykd k + KIAA0302 2243 EQMEGMLCRKQemeafgkkaANRSWQNVYCVLRRGSLGFYKDAKaas 2289 ..kkpkgsipLsgiqvtkvpdn...krkncFeirt.dretlllqaeseee + + g +p+s ++ ++ + +krk++F++ +d++++l+qa++e e KIAA0302 2290 agVPYHGEVPVSLARAQGSVAFdyrKRKHVFKLGLqDGKEYLFQAKDEAE 2339 rkeWvkaiqsair<-* + +W++ + ai+ KIAA0302 2340 MSSWLRVVNAAIA 2352 //