# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/ha07059.fasta.nr -Q ../query/KIAA0259.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA0259, 1550 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7826138 sequences Expectation_n fit: rho(ln(x))= 5.6032+/-0.000187; mu= 13.6262+/- 0.010 mean_var=81.4047+/-15.894, 0's: 49 Z-trim: 53 B-trim: 390 in 1/65 Lambda= 0.142151 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 41, opt: 29, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|114589472|ref|XP_516761.2| PREDICTED: topoisome (1587) 10274 2117.8 0 gi|62901464|sp|Q92547.2|TOPB1_HUMAN RecName: Full= (1522) 10117 2085.6 0 gi|119599579|gb|EAW79173.1| topoisomerase (DNA) II (1522) 10112 2084.6 0 gi|109049445|ref|XP_001112636.1| PREDICTED: topois (1622) 10112 2084.6 0 gi|221044154|dbj|BAH13754.1| unnamed protein produ (1522) 10095 2081.1 0 gi|3845613|dbj|BAA34202.1| DNA topoisomerase II bi (1435) 9534 1966.0 0 gi|133778287|gb|AAI26210.2| Topoisomerase (DNA) II (1435) 9529 1965.0 0 gi|73990583|ref|XP_534266.2| PREDICTED: similar to (1697) 9343 1926.9 0 gi|119599581|gb|EAW79175.1| topoisomerase (DNA) II (1297) 8562 1766.6 0 gi|109483894|ref|XP_236578.4| PREDICTED: similar t (1594) 8027 1657.0 0 gi|119599580|gb|EAW79174.1| topoisomerase (DNA) II (1215) 7918 1634.5 0 gi|62901438|sp|Q6ZQF0.2|TOPB1_MOUSE RecName: Full= (1515) 7779 1606.1 0 gi|194685166|ref|XP_612160.4| PREDICTED: similar t (1214) 7140 1475.0 0 gi|13938110|gb|AAH07170.1| Topbp1 protein [Mus mus (1296) 6377 1318.5 0 gi|213625410|gb|AAI70557.1| Cut5-related protein [ (1513) 5335 1104.9 0 gi|28881882|dbj|BAC65235.1| Cut5-related protein [ (1513) 5329 1103.7 0 gi|30016918|gb|AAP03894.1| Xmus101 [Xenopus laevis (1513) 5257 1088.9 0 gi|38566069|gb|AAH62111.1| Topbp1 protein [Mus mus ( 887) 4319 896.4 0 gi|194221610|ref|XP_001917288.1| PREDICTED: simila (1451) 3737 777.2 0 gi|13879456|gb|AAH06707.1| Topbp1 protein [Mus mus ( 615) 3055 637.0 1.3e-179 gi|210116106|gb|EEA63852.1| hypothetical protein B (1460) 2712 567.0 3.8e-158 gi|20073005|gb|AAH26608.1| Topbp1 protein [Mus mus ( 483) 2350 492.4 3.5e-136 gi|45709557|gb|AAH67694.1| Topbp1 protein [Danio r ( 666) 2133 448.0 1.1e-122 gi|156218041|gb|EDO38946.1| predicted protein [Nem (1428) 1568 332.3 1.6e-87 gi|47221191|emb|CAG05512.1| unnamed protein produc ( 997) 1550 328.5 1.5e-86 gi|116283817|gb|AAH32633.1| TOPBP1 protein [Homo s ( 184) 1220 260.4 9.4e-67 gi|26351417|dbj|BAC39345.1| unnamed protein produc ( 183) 1133 242.5 2.2e-61 gi|74217147|dbj|BAC39241.2| unnamed protein produc ( 179) 1108 237.4 7.5e-60 gi|215500576|gb|EEC10070.1| topbp1, putative [Ixod (1362) 1110 238.4 2.8e-59 gi|115758101|ref|XP_788169.2| PREDICTED: similar t ( 651) 1041 224.0 2.9e-55 gi|115934500|ref|XP_001191231.1| PREDICTED: simila (1241) 1041 224.2 4.8e-55 gi|210112544|gb|EEA60320.1| hypothetical protein B (1738) 1031 222.3 2.6e-54 gi|115935447|ref|XP_001188843.1| PREDICTED: simila ( 333) 939 202.9 3.3e-49 gi|115657204|ref|XP_792960.2| PREDICTED: similar t ( 297) 924 199.8 2.6e-48 gi|159163289|pdb|1WF6|A Chain A, The Third Brca1 C ( 132) 820 178.2 3.6e-42 gi|167870653|gb|EDS34036.1| DNA topoisomerase 2-bi (1363) 698 153.9 7.8e-34 gi|47182206|emb|CAG14479.1| unnamed protein produc ( 182) 649 143.3 1.7e-31 gi|190587614|gb|EDV27656.1| hypothetical protein T (1339) 647 143.4 1.1e-30 gi|115637561|ref|XP_001198408.1| PREDICTED: simila ( 498) 633 140.3 3.6e-30 gi|115926191|ref|XP_001192290.1| PREDICTED: simila ( 691) 633 140.4 4.6e-30 gi|218185404|gb|EEC67831.1| hypothetical protein O ( 978) 578 129.2 1.5e-26 gi|215687334|dbj|BAG91866.1| unnamed protein produ ( 901) 572 127.9 3.3e-26 gi|221108243|ref|XP_002169301.1| PREDICTED: simila ( 918) 545 122.4 1.6e-24 gi|193620231|ref|XP_001946820.1| PREDICTED: simila ( 310) 501 113.1 3.5e-22 gi|157017959|gb|EAA07850.4| AGAP002760-PA [Anophel (1387) 505 114.3 6.5e-22 gi|198414774|ref|XP_002127395.1| PREDICTED: simila ( 559) 485 110.0 5.4e-21 gi|110755222|ref|XP_394416.3| PREDICTED: similar t (1192) 486 110.4 8.5e-21 gi|190619627|gb|EDV35151.1| GF22599 [Drosophila an (1435) 466 106.3 1.7e-19 gi|34978932|gb|AAQ83675.1| epithelial cell transfo ( 882) 462 105.4 2e-19 gi|212276511|sp|Q9H8V3.3|ECT2_HUMAN RecName: Full= ( 883) 462 105.4 2e-19 >>gi|114589472|ref|XP_516761.2| PREDICTED: topoisomerase (1587 aa) initn: 10274 init1: 10274 opt: 10274 Z-score: 11376.3 bits: 2117.8 E(): 0 Smith-Waterman score: 10274; 99.548% identity (99.806% similar) in 1550 aa overlap (1-1550:38-1587) 10 20 30 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMS :::::::::::::::::::::::::::::: gi|114 KASAAARLARNVCFGVGAAPSRGRGLCAGLAPDPSHRPAASASPDSPPGDPEAPTSSEMS 10 20 30 40 50 60 40 50 60 70 80 90 KIAA02 RNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDP 70 80 90 100 110 120 100 110 120 130 140 150 KIAA02 FSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKRE 130 140 150 160 170 180 160 170 180 190 200 210 KIAA02 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK 190 200 210 220 230 240 220 230 240 250 260 270 KIAA02 KITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI 250 260 270 280 290 300 280 290 300 310 320 330 KIAA02 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQ 310 320 330 340 350 360 340 350 360 370 380 390 KIAA02 INTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 INTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGC 370 380 390 400 410 420 400 410 420 430 440 450 KIAA02 RIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVV 430 440 450 460 470 480 460 470 480 490 500 510 KIAA02 GAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPSEK 490 500 510 520 530 540 520 530 540 550 560 570 KIAA02 HEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVP :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: gi|114 HEQADEDLLSQYENDSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCVP 550 560 570 580 590 600 580 590 600 610 620 630 KIAA02 DVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCE 610 620 630 640 650 660 640 650 660 670 680 690 KIAA02 VEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKE 670 680 690 700 710 720 700 710 720 730 740 750 KIAA02 SLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLL 730 740 750 760 770 780 760 770 780 790 800 810 KIAA02 ETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLD :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: gi|114 ETARTGKRADESHFLIENSSKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPLD 790 800 810 820 830 840 820 830 840 850 860 870 KIAA02 MNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDA 850 860 870 880 890 900 880 890 900 910 920 930 KIAA02 LAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAP :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: gi|114 LAALETPGRPSQQKRKLSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAP 910 920 930 940 950 960 940 950 960 970 980 990 KIAA02 KPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVK ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: gi|114 KPLHKVVVCVSKKLGKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVK 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 KIAA02 ERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: gi|114 ERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSATK 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 KIAA02 DDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSAT 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 KIAA02 SIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQ ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: gi|114 SIVKPQGQRTSLSRSGCNSASSTPDSSRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQ 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 KIAA02 IIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 IIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDP 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 KIAA02 GNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHE ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: gi|114 GNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIIMIEETHE 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 KIAA02 ELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASV 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 KIAA02 AAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQ 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 KIAA02 QRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDLN 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 KIAA02 KLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTG 1510 1520 1530 1540 1550 1560 1540 1550 KIAA02 LSQKRKAPTEKNKIKRPRVH :::::::::::::::::::: gi|114 LSQKRKAPTEKNKIKRPRVH 1570 1580 >>gi|62901464|sp|Q92547.2|TOPB1_HUMAN RecName: Full=DNA (1522 aa) initn: 10117 init1: 10117 opt: 10117 Z-score: 11202.5 bits: 2085.6 E(): 0 Smith-Waterman score: 10117; 100.000% identity (100.000% similar) in 1522 aa overlap (29-1550:1-1522) 10 20 30 40 50 60 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMSRNDKEPFFVKFLKSSDNSKCFFKALESIKE :::::::::::::::::::::::::::::::: gi|629 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKE 10 20 30 70 80 90 100 110 120 KIAA02 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR 40 50 60 70 80 90 130 140 150 160 170 180 KIAA02 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG 100 110 120 130 140 150 190 200 210 220 230 240 KIAA02 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG 160 170 180 190 200 210 250 260 270 280 290 300 KIAA02 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE 220 230 240 250 260 270 310 320 330 340 350 360 KIAA02 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS 280 290 300 310 320 330 370 380 390 400 410 420 KIAA02 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL 340 350 360 370 380 390 430 440 450 460 470 480 KIAA02 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI 400 410 420 430 440 450 490 500 510 520 530 540 KIAA02 PVSHQPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 PVSHQPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF 460 470 480 490 500 510 550 560 570 580 590 600 KIAA02 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA 520 530 540 550 560 570 610 620 630 640 650 660 KIAA02 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP 580 590 600 610 620 630 670 680 690 700 710 720 KIAA02 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS 640 650 660 670 680 690 730 740 750 760 770 780 KIAA02 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI 700 710 720 730 740 750 790 800 810 820 830 840 KIAA02 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL 760 770 780 790 800 810 850 860 870 880 890 900 KIAA02 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ 820 830 840 850 860 870 910 920 930 940 950 960 KIAA02 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA 880 890 900 910 920 930 970 980 990 1000 1010 1020 KIAA02 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 KIAA02 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 KIAA02 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 KIAA02 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 KIAA02 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP 1180 1190 1200 1210 1220 1230 1270 1280 1290 1300 1310 1320 KIAA02 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 KIAA02 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG 1300 1310 1320 1330 1340 1350 1390 1400 1410 1420 1430 1440 KIAA02 SSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 SSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFK 1360 1370 1380 1390 1400 1410 1450 1460 1470 1480 1490 1500 KIAA02 RLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 RLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADY 1420 1430 1440 1450 1460 1470 1510 1520 1530 1540 1550 KIAA02 LMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH :::::::::::::::::::::::::::::::::::::::::::::::::: gi|629 LMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH 1480 1490 1500 1510 1520 >>gi|119599579|gb|EAW79173.1| topoisomerase (DNA) II bin (1522 aa) initn: 10112 init1: 10112 opt: 10112 Z-score: 11197.0 bits: 2084.6 E(): 0 Smith-Waterman score: 10112; 99.934% identity (100.000% similar) in 1522 aa overlap (29-1550:1-1522) 10 20 30 40 50 60 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMSRNDKEPFFVKFLKSSDNSKCFFKALESIKE :::::::::::::::::::::::::::::::: gi|119 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKE 10 20 30 70 80 90 100 110 120 KIAA02 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR 40 50 60 70 80 90 130 140 150 160 170 180 KIAA02 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG 100 110 120 130 140 150 190 200 210 220 230 240 KIAA02 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG 160 170 180 190 200 210 250 260 270 280 290 300 KIAA02 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE 220 230 240 250 260 270 310 320 330 340 350 360 KIAA02 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS 280 290 300 310 320 330 370 380 390 400 410 420 KIAA02 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL 340 350 360 370 380 390 430 440 450 460 470 480 KIAA02 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI 400 410 420 430 440 450 490 500 510 520 530 540 KIAA02 PVSHQPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF 460 470 480 490 500 510 550 560 570 580 590 600 KIAA02 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA 520 530 540 550 560 570 610 620 630 640 650 660 KIAA02 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP 580 590 600 610 620 630 670 680 690 700 710 720 KIAA02 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS 640 650 660 670 680 690 730 740 750 760 770 780 KIAA02 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI 700 710 720 730 740 750 790 800 810 820 830 840 KIAA02 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL 760 770 780 790 800 810 850 860 870 880 890 900 KIAA02 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ 820 830 840 850 860 870 910 920 930 940 950 960 KIAA02 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA 880 890 900 910 920 930 970 980 990 1000 1010 1020 KIAA02 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 KIAA02 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 KIAA02 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 KIAA02 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 KIAA02 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP 1180 1190 1200 1210 1220 1230 1270 1280 1290 1300 1310 1320 KIAA02 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 KIAA02 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG 1300 1310 1320 1330 1340 1350 1390 1400 1410 1420 1430 1440 KIAA02 SSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFK 1360 1370 1380 1390 1400 1410 1450 1460 1470 1480 1490 1500 KIAA02 RLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADY 1420 1430 1440 1450 1460 1470 1510 1520 1530 1540 1550 KIAA02 LMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH :::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH 1480 1490 1500 1510 1520 >>gi|109049445|ref|XP_001112636.1| PREDICTED: topoisomer (1622 aa) initn: 6567 init1: 6567 opt: 10112 Z-score: 11196.6 bits: 2084.6 E(): 0 Smith-Waterman score: 10112; 97.556% identity (99.293% similar) in 1555 aa overlap (1-1550:68-1622) 10 20 30 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMS :::::: ::.:::::::::::::::::::: gi|109 FPFWSISGFSSVCFGVGAAPSRGRGLCAGLAPDPSHGPAGSASPDSPPGDPEAPTSSEMS 40 50 60 70 80 90 40 50 60 70 80 90 KIAA02 RNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDP 100 110 120 130 140 150 100 110 120 130 140 150 KIAA02 FSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKRE :::.::::::::::::::::::::::::::::::::::::::::::::.::::::::::: gi|109 FSGIVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTVSCTSLEKEKRE 160 170 180 190 200 210 160 170 180 190 200 210 KIAA02 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK 220 230 240 250 260 270 220 230 240 250 260 270 KIAA02 KITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI 280 290 300 310 320 330 280 290 300 310 320 330 KIAA02 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQ ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::.: gi|109 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESMYKTEPRPEAKTMPNSSTPTGQ 340 350 360 370 380 390 340 350 360 370 380 390 KIAA02 INTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGC ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: gi|109 INTIDSRTLSDVSNISNINASCISESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGC 400 410 420 430 440 450 400 410 420 430 440 450 KIAA02 RIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVV 460 470 480 490 500 510 460 470 480 490 500 510 KIAA02 GAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPSEK ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: gi|109 GAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSDQPESKAALLKKKNSSFSKKDFAPSEK 520 530 540 550 560 570 520 530 540 550 560 KIAA02 HEQADEDLLSQYENGSSTVVEAKTSEA-----RPFNDSTHAEPLNDSTHISLQEENQSSV .::::::::::::: :::::::::::: ::::.::.:::::::::.:::::::::: gi|109 REQADEDLLSQYENDSSTVVEAKTSEAEKSEVRPFNNSTRAEPLNDSTHVSLQEENQSSV 580 590 600 610 620 630 570 580 590 600 610 620 KIAA02 SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVP :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: gi|109 SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIASIIKENAGKIMSLLSRTVADYAVVP 640 650 660 670 680 690 630 640 650 660 670 680 KIAA02 LLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCA ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|109 LLGCEVEATVGEVVTNTWLVTCIDFQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCA 700 710 720 730 740 750 690 700 710 720 730 740 KIAA02 GAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVT :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: gi|109 GAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKEPGGSKYEAAKKWNLPAVT 760 770 780 790 800 810 750 760 770 780 790 800 KIAA02 IAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTV ::::::::::::::::::::::::..:::::::::::::::::::::::::::::::::: gi|109 IAWLLETARTGKRADESHFLIENSSEEERSLETEITNGINLNSDTAEHPGTRLQTHRKTV 820 830 840 850 860 870 810 820 830 840 850 860 KIAA02 VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSF .::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: gi|109 ITPLDMNRFQSKAFRAVVSQHARQVSASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSF 880 890 900 910 920 930 870 880 890 900 910 920 KIAA02 DVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSE :::::::::::::.::::::: :::::::::::::::::::::::::::::::::::::: gi|109 DVKDALAALETPGHPSQQKRKLSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSE 940 950 960 970 980 990 930 940 950 960 970 980 KIAA02 KEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNRE :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KEEAPKPLHRVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNRE 1000 1010 1020 1030 1040 1050 990 1000 1010 1020 1030 1040 KIAA02 YKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSA ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: gi|109 YKSVKERGVHIVSEHWLLDCAQEYKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSA 1060 1070 1080 1090 1100 1110 1050 1060 1070 1080 1090 1100 KIAA02 VSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE ::.:::::::::::::::::::::::::::::::.::::::::::::::::::::::::: gi|109 VSATKDDEPDPLILEENDVDNMATNNKESAPSNGNGKNDSKGVLTQTLEMRENFQKQLQE 1120 1130 1140 1150 1160 1170 1110 1120 1130 1140 1150 1160 KIAA02 IMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 IMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEP 1180 1190 1200 1210 1220 1230 1170 1180 1190 1200 1210 1220 KIAA02 SQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQ :::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::: gi|109 SQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQRPLRDSEIAKQ 1240 1250 1260 1270 1280 1290 1230 1240 1250 1260 1270 1280 KIAA02 AVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITI ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 AVCDPGDIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITI 1300 1310 1320 1330 1340 1350 1290 1300 1310 1320 1330 1340 KIAA02 EETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEK :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: gi|109 EETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPSCTHIVVGHPLRNEK 1360 1370 1380 1390 1400 1410 1350 1360 1370 1380 1390 1400 KIAA02 YLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 YLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRW 1420 1430 1440 1450 1460 1470 1410 1420 1430 1440 1450 1460 KIAA02 RKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 RKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHL 1480 1490 1500 1510 1520 1530 1470 1480 1490 1500 1510 1520 KIAA02 FSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNK ::::::::::::::::.::::::::::::::::::::::::::::::::::::::.:::: gi|109 FSDLNKLKPDDSGVNITEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFLQNNK 1540 1550 1560 1570 1580 1590 1530 1540 1550 KIAA02 ELGTGLSQKRKAPTEKNKIKRPRVH ::::::::::::::::::.:::::: gi|109 ELGTGLSQKRKAPTEKNKMKRPRVH 1600 1610 1620 >>gi|221044154|dbj|BAH13754.1| unnamed protein product [ (1522 aa) initn: 10095 init1: 10095 opt: 10095 Z-score: 11178.1 bits: 2081.1 E(): 0 Smith-Waterman score: 10095; 99.869% identity (99.934% similar) in 1522 aa overlap (29-1550:1-1522) 10 20 30 40 50 60 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMSRNDKEPFFVKFLKSSDNSKCFFKALESIKE :::::::::::::::::::::::::::::::: gi|221 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKE 10 20 30 70 80 90 100 110 120 KIAA02 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR 40 50 60 70 80 90 130 140 150 160 170 180 KIAA02 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG 100 110 120 130 140 150 190 200 210 220 230 240 KIAA02 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG 160 170 180 190 200 210 250 260 270 280 290 300 KIAA02 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE 220 230 240 250 260 270 310 320 330 340 350 360 KIAA02 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS 280 290 300 310 320 330 370 380 390 400 410 420 KIAA02 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL 340 350 360 370 380 390 430 440 450 460 470 480 KIAA02 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI 400 410 420 430 440 450 490 500 510 520 530 540 KIAA02 PVSHQPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 PVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF 460 470 480 490 500 510 550 560 570 580 590 600 KIAA02 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA 520 530 540 550 560 570 610 620 630 640 650 660 KIAA02 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP 580 590 600 610 620 630 670 680 690 700 710 720 KIAA02 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS 640 650 660 670 680 690 730 740 750 760 770 780 KIAA02 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI 700 710 720 730 740 750 790 800 810 820 830 840 KIAA02 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL 760 770 780 790 800 810 850 860 870 880 890 900 KIAA02 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ 820 830 840 850 860 870 910 920 930 940 950 960 KIAA02 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: gi|221 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVRVSKKLSKKQSELNGIAASLGA 880 890 900 910 920 930 970 980 990 1000 1010 1020 KIAA02 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 KIAA02 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 KIAA02 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 KIAA02 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 KIAA02 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP 1180 1190 1200 1210 1220 1230 1270 1280 1290 1300 1310 1320 KIAA02 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 KIAA02 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG 1300 1310 1320 1330 1340 1350 1390 1400 1410 1420 1430 1440 KIAA02 SSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 SSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFK 1360 1370 1380 1390 1400 1410 1450 1460 1470 1480 1490 1500 KIAA02 RLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 RLLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADY 1420 1430 1440 1450 1460 1470 1510 1520 1530 1540 1550 KIAA02 LMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH :::::::::::::::::::::::::::::::::::::::::::::::::: gi|221 LMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH 1480 1490 1500 1510 1520 >>gi|3845613|dbj|BAA34202.1| DNA topoisomerase II bindin (1435 aa) initn: 9534 init1: 9534 opt: 9534 Z-score: 10556.7 bits: 1966.0 E(): 0 Smith-Waterman score: 9534; 100.000% identity (100.000% similar) in 1435 aa overlap (116-1550:1-1435) 90 100 110 120 130 140 KIAA02 YICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLE :::::::::::::::::::::::::::::: gi|384 MHHQRCVPRAEHPVYNMVMSDVTISCTSLE 10 20 30 150 160 170 180 190 200 KIAA02 KEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 KEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWE 40 50 60 70 80 90 210 220 230 240 250 260 KIAA02 KSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 KSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNE 100 110 120 130 140 150 270 280 290 300 310 320 KIAA02 CTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 CTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSS 160 170 180 190 200 210 330 340 350 360 370 380 KIAA02 TPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 TPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPED 220 230 240 250 260 270 390 400 410 420 430 440 KIAA02 LLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 LLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAH 280 290 300 310 320 330 450 460 470 480 490 500 KIAA02 RPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 RPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDF 340 350 360 370 380 390 510 520 530 540 550 560 KIAA02 APSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 APSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV 400 410 420 430 440 450 570 580 590 600 610 620 KIAA02 SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVP 460 470 480 490 500 510 630 640 650 660 670 680 KIAA02 LLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 LLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCA 520 530 540 550 560 570 690 700 710 720 730 740 KIAA02 GAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 GAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVT 580 590 600 610 620 630 750 760 770 780 790 800 KIAA02 IAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 IAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTV 640 650 660 670 680 690 810 820 830 840 850 860 KIAA02 VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSF 700 710 720 730 740 750 870 880 890 900 910 920 KIAA02 DVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 DVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSE 760 770 780 790 800 810 930 940 950 960 970 980 KIAA02 KEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 KEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNRE 820 830 840 850 860 870 990 1000 1010 1020 1030 1040 KIAA02 YKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 YKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSA 880 890 900 910 920 930 1050 1060 1070 1080 1090 1100 KIAA02 VSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 VSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE 940 950 960 970 980 990 1110 1120 1130 1140 1150 1160 KIAA02 IMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 IMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEP 1000 1010 1020 1030 1040 1050 1170 1180 1190 1200 1210 1220 KIAA02 SQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 SQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQ 1060 1070 1080 1090 1100 1110 1230 1240 1250 1260 1270 1280 KIAA02 AVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 AVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITI 1120 1130 1140 1150 1160 1170 1290 1300 1310 1320 1330 1340 KIAA02 EETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 EETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEK 1180 1190 1200 1210 1220 1230 1350 1360 1370 1380 1390 1400 KIAA02 YLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 YLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRW 1240 1250 1260 1270 1280 1290 1410 1420 1430 1440 1450 1460 KIAA02 RKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 RKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHL 1300 1310 1320 1330 1340 1350 1470 1480 1490 1500 1510 1520 KIAA02 FSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|384 FSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNK 1360 1370 1380 1390 1400 1410 1530 1540 1550 KIAA02 ELGTGLSQKRKAPTEKNKIKRPRVH ::::::::::::::::::::::::: gi|384 ELGTGLSQKRKAPTEKNKIKRPRVH 1420 1430 >>gi|133778287|gb|AAI26210.2| Topoisomerase (DNA) II bin (1435 aa) initn: 9529 init1: 9529 opt: 9529 Z-score: 10551.2 bits: 1965.0 E(): 0 Smith-Waterman score: 9529; 99.930% identity (100.000% similar) in 1435 aa overlap (116-1550:1-1435) 90 100 110 120 130 140 KIAA02 YICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLE :::::::::::::::::::::::::::::: gi|133 MHHQRCVPRAEHPVYNMVMSDVTISCTSLE 10 20 30 150 160 170 180 190 200 KIAA02 KEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 KEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWE 40 50 60 70 80 90 210 220 230 240 250 260 KIAA02 KSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 KSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNE 100 110 120 130 140 150 270 280 290 300 310 320 KIAA02 CTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 CTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSS 160 170 180 190 200 210 330 340 350 360 370 380 KIAA02 TPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 TPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPED 220 230 240 250 260 270 390 400 410 420 430 440 KIAA02 LLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 LLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAH 280 290 300 310 320 330 450 460 470 480 490 500 KIAA02 RPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDF :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: gi|133 RPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDF 340 350 360 370 380 390 510 520 530 540 550 560 KIAA02 APSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 APSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV 400 410 420 430 440 450 570 580 590 600 610 620 KIAA02 SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 SHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVP 460 470 480 490 500 510 630 640 650 660 670 680 KIAA02 LLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 LLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCA 520 530 540 550 560 570 690 700 710 720 730 740 KIAA02 GAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 GAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVT 580 590 600 610 620 630 750 760 770 780 790 800 KIAA02 IAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 IAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTV 640 650 660 670 680 690 810 820 830 840 850 860 KIAA02 VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSF 700 710 720 730 740 750 870 880 890 900 910 920 KIAA02 DVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 DVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSE 760 770 780 790 800 810 930 940 950 960 970 980 KIAA02 KEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 KEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNRE 820 830 840 850 860 870 990 1000 1010 1020 1030 1040 KIAA02 YKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 YKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSA 880 890 900 910 920 930 1050 1060 1070 1080 1090 1100 KIAA02 VSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 VSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE 940 950 960 970 980 990 1110 1120 1130 1140 1150 1160 KIAA02 IMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 IMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEP 1000 1010 1020 1030 1040 1050 1170 1180 1190 1200 1210 1220 KIAA02 SQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 SQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQ 1060 1070 1080 1090 1100 1110 1230 1240 1250 1260 1270 1280 KIAA02 AVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 AVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITI 1120 1130 1140 1150 1160 1170 1290 1300 1310 1320 1330 1340 KIAA02 EETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 EETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEK 1180 1190 1200 1210 1220 1230 1350 1360 1370 1380 1390 1400 KIAA02 YLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 YLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRW 1240 1250 1260 1270 1280 1290 1410 1420 1430 1440 1450 1460 KIAA02 RKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 RKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHL 1300 1310 1320 1330 1340 1350 1470 1480 1490 1500 1510 1520 KIAA02 FSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|133 FSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNK 1360 1370 1380 1390 1400 1410 1530 1540 1550 KIAA02 ELGTGLSQKRKAPTEKNKIKRPRVH ::::::::::::::::::::::::: gi|133 ELGTGLSQKRKAPTEKNKIKRPRVH 1420 1430 >>gi|73990583|ref|XP_534266.2| PREDICTED: similar to DNA (1697 aa) initn: 8421 init1: 6055 opt: 9343 Z-score: 10344.0 bits: 1926.9 E(): 0 Smith-Waterman score: 9343; 89.877% identity (96.325% similar) in 1551 aa overlap (1-1550:152-1697) 10 20 30 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMS :::::.: :. : ::: :.:: ::.:: gi|739 KVGSPPRQFPGSASASGRGRRGLRRVCAGLAPDPSRRLAGRAPLRSPPEGPQAPPSSKMS 130 140 150 160 170 180 40 50 60 70 80 90 KIAA02 RNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDP :::::::.::::::::::.:::::::::::::::::::::::::::::.::::::::::: gi|739 RNDKEPFLVKFLKSSDNSECFFKALESIKEFQSEEYLQIITEEEALKIQENDRSLYICDP 190 200 210 220 230 240 100 110 120 130 140 150 KIAA02 FSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKRE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: gi|739 FSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKDKRE 250 260 270 280 290 300 160 170 180 190 200 210 KIAA02 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: gi|739 EVHKYVQMMGGRVYRDLNISVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK 310 320 330 340 350 360 220 230 240 250 260 270 KIAA02 KITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI ::.::::.:::::::::::::::::::::.:::: ::::::::::::::::::::::::: gi|739 KISRYTDVNMEDFKCPIFLGCIICVTGLCSLDRKAVQQLTVKHGGQYMGQLKMNECTHLI 370 380 390 400 410 420 280 290 300 310 320 330 KIAA02 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQ ::::::::::::::::::::::::::::..:::::::::::::::::.::::..::::.: gi|739 VQEPKGQKYECAKRWNVHCVTTQWFFDSVDKGFCQDESIYKTEPRPETKTMPDTSTPTGQ 430 440 450 460 470 480 340 350 360 370 380 KIAA02 INTIDSRTLSDVSNISNINASCVSESICNS-LNSKLEPTLENLENLDVSAFQAPEDLLDG :.:.:::::::::.::::::::..::.::: ::::.:::::::::::::::::::::::: gi|739 IHTVDSRTLSDVSHISNINASCINESMCNSVLNSKVEPTLENLENLDVSAFQAPEDLLDG 490 500 510 520 530 540 390 400 410 420 430 440 KIAA02 CRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHV :::::::::::.:::::::::::::::::::::::::::::::::::::::.:::::::: gi|739 CRIYLCGFSGRRLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWDKSAHRPHV 550 560 570 580 590 600 450 460 470 480 490 500 KIAA02 VGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPSE :::::::::::::::: :: :::::::::::::: :::.:.::::: :.:::::::: .: gi|739 VGAKWLLECFSKGYMLPEETYIHANYQPVEIPVSDQPENKTALLKK-NNSFSKKDFASDE 610 620 630 640 650 660 510 520 530 540 550 560 KIAA02 KHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHCV ::::::::::::: :.. ::: . ::: ....::.::::::: :.:::::..::. gi|739 KHEQADEDLLSQYVNNNPTVVFSPLSEAV----KSEVEPFNDSTHISPQKENQSSATHCL 670 680 690 700 710 570 580 590 600 610 620 KIAA02 PDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGC ::.:: ::::::::::::::::::::::::::::.:::::..:: :: :::::::::::: gi|739 PDASTTTEEGLFSQKSFLVLGFSNENESNIANIIRENAGKVVSLQSRIVADYAVVPLLGC 720 730 740 750 760 770 630 640 650 660 670 680 KIAA02 EVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEK ::::::::::::::::::::::::.:::::::: ::: :.:::::::::::::::::::: gi|739 EVEATVGEVVTNTWLVTCIDYQTLIDPKSNPLFMPVPFMAGMTPLEDCVISFSQCAGAEK 780 790 800 810 820 830 690 700 710 720 730 740 KIAA02 ESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWL .::::::: :::::::.:::::::::::::::::.::: ::::::::::::::::::.:: gi|739 DSLTFLANRLGASVQEFFVRKSNAKKGMFASTHLVLKEPGGSKYEAAKKWNLPAVTISWL 840 850 860 870 880 890 750 760 770 780 790 800 KIAA02 LETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPL ::::: ::::.:.:::::.:::::.:::::::: .::: :: ::: ..:.:.:::.:::: gi|739 LETARMGKRANENHFLIEKSTKEEQSLETEITNKVNLNPDTPEHPVAHLETQRKTAVTPL 900 910 920 930 940 950 810 820 830 840 850 860 KIAA02 DMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKD :::::::.::.::.:::..::..: :::::::::::::::::::::::::::::::::: gi|739 DMNRFQSRAFHAVISQHTKQVSTSSPVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKD 960 970 980 990 1000 1010 870 880 890 900 910 920 KIAA02 ALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEA ::::::::: ::::::: :::::::::.::.:::::::::::::::::.::.:::::.:: gi|739 ALAALETPGGPSQQKRKLSTPLSEVIVRNLKLALANSSRNAVALSASPRLKDAQSEKDEA 1020 1030 1040 1050 1060 1070 930 940 950 960 970 980 KIAA02 PKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 PKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSV 1080 1090 1100 1110 1120 1130 990 1000 1010 1020 1030 1040 KIAA02 KERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSST ::::::::::::::.:::: :::::::::::::::::::::.:::::. ::::::: :.: gi|739 KERGVHIVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDISTVQDGRISNSRLLSADSTT 1140 1150 1160 1170 1180 1190 1050 1060 1070 1080 1090 1100 KIAA02 KDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSA :::::: : ::::.:::.:.::::: :::.:.:::::.::::::::::::::::::::: gi|739 KDDEPDHLPGEENDIDNMTTSNKESATSNGDGRNDSKGALTQTLEMRENFQKQLQEIMSA 1200 1210 1220 1230 1240 1250 1110 1120 1130 1140 1150 1160 KIAA02 TSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNE :::::::: :.::::::::::::::::::::::::::::::::::::::::.:::::::: gi|739 TSIVKPQGPRASLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDINTEPSQNE 1260 1270 1280 1290 1300 1310 1170 1180 1190 1200 1210 1220 KIAA02 QIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCD ::::::::::::::::::::::::::::::::::::..:::::::.:::: :::.::::: gi|739 QIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIKKLEDSPFQEPLHDPEIAEQAVCD 1320 1330 1340 1350 1360 1370 1230 1240 1250 1260 1270 1280 KIAA02 PGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETH :::. :::::::: :::::::.:::::::::::::::::::::::::::::::::::::: gi|739 PGNVCVTEAPKHPTSEELETPVKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETH 1380 1390 1400 1410 1420 1430 1290 1300 1310 1320 1330 1340 KIAA02 EELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLAS :.:::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: gi|739 EDLKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPNCTHIVVGHPLRNEKYLAS 1440 1450 1460 1470 1480 1490 1350 1360 1370 1380 1390 1400 KIAA02 VAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKI ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: gi|739 VAAGKWVLHRSYLEACRTAGHFVLEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKI 1500 1510 1520 1530 1540 1550 1410 1420 1430 1440 1450 1460 KIAA02 QQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|739 QQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSDF 1560 1570 1580 1590 1600 1610 1470 1480 1490 1500 1510 1520 KIAA02 NKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGT :::::::::::::::::::::::.:::::::::::::: :::::::::.::.::::: : gi|739 NKLKPDDSGVNIAEAAAQNVYCLKTEYIADYLMQESPPPVENYCLPEAVSFLQNNKEPGP 1620 1630 1640 1650 1660 1670 1530 1540 1550 KIAA02 GLSQKRKAPTEKNKIKRPRVH ::::::::::::::::::::. gi|739 GLSQKRKAPTEKNKIKRPRVN 1680 1690 >>gi|119599581|gb|EAW79175.1| topoisomerase (DNA) II bin (1297 aa) initn: 8558 init1: 8558 opt: 8562 Z-score: 9480.0 bits: 1766.6 E(): 0 Smith-Waterman score: 8562; 99.537% identity (99.769% similar) in 1297 aa overlap (29-1325:1-1297) 10 20 30 40 50 60 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMSRNDKEPFFVKFLKSSDNSKCFFKALESIKE :::::::::::::::::::::::::::::::: gi|119 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKE 10 20 30 70 80 90 100 110 120 KIAA02 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 FQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQR 40 50 60 70 80 90 130 140 150 160 170 180 KIAA02 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 CVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG 100 110 120 130 140 150 190 200 210 220 230 240 KIAA02 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCG 160 170 180 190 200 210 250 260 270 280 290 300 KIAA02 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIE 220 230 240 250 260 270 310 320 330 340 350 360 KIAA02 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNS 280 290 300 310 320 330 370 380 390 400 410 420 KIAA02 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQL 340 350 360 370 380 390 430 440 450 460 470 480 KIAA02 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEI 400 410 420 430 440 450 490 500 510 520 530 540 KIAA02 PVSHQPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPF 460 470 480 490 500 510 550 560 570 580 590 600 KIAA02 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIA 520 530 540 550 560 570 610 620 630 640 650 660 KIAA02 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 NIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNP 580 590 600 610 620 630 670 680 690 700 710 720 KIAA02 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFAS 640 650 660 670 680 690 730 740 750 760 770 780 KIAA02 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 THLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEI 700 710 720 730 740 750 790 800 810 820 830 840 KIAA02 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TNGINLNSDTAEHPGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPL 760 770 780 790 800 810 850 860 870 880 890 900 KIAA02 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQ 820 830 840 850 860 870 910 920 930 940 950 960 KIAA02 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGA 880 890 900 910 920 930 970 980 990 1000 1010 1020 KIAA02 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 DYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHT 940 950 960 970 980 990 1030 1040 1050 1060 1070 1080 KIAA02 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGS 1000 1010 1020 1030 1040 1050 1090 1100 1110 1120 1130 1140 KIAA02 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSA 1060 1070 1080 1090 1100 1110 1150 1160 1170 1180 1190 1200 KIAA02 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSE 1120 1130 1140 1150 1160 1170 1210 1220 1230 1240 1250 1260 KIAA02 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LQVDIQNLEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTP 1180 1190 1200 1210 1220 1230 1270 1280 1290 1300 1310 1320 KIAA02 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGT 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 KIAA02 LVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWG .. : gi|119 SILLK >>gi|109483894|ref|XP_236578.4| PREDICTED: similar to to (1594 aa) initn: 7044 init1: 2598 opt: 8027 Z-score: 8885.8 bits: 1657.0 E(): 0 Smith-Waterman score: 8027; 77.150% identity (90.436% similar) in 1558 aa overlap (1-1550:48-1594) 10 20 30 KIAA02 APDPSHRPAASASPDSPPGDPEAPTSSEMS :::::.:::. : :: : :.:: :: :: gi|109 SRFLVLALPGTAALTSGWGRRRGRGLRAGLAPDPSRRPAGRAPPDLVPVGPRAPPSSAMS 20 30 40 50 60 70 40 50 60 70 80 90 KIAA02 RNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDP :::.::::::::::::::.:::::::::::.:::::::.::.::::.:::::.:::::: gi|109 RNDQEPFFVKFLKSSDNSECFFKALESIKELQSEEYLQVITDEEALRIKENDKSLYICDR 80 90 100 110 120 130 100 110 120 130 140 150 KIAA02 FSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKRE :::..:::::.::::::::::: :::.::.::::::::::::.:::.:::::::.:.::: gi|109 FSGTAFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDITISCTSLDKDKRE 140 150 160 170 180 190 160 170 180 190 200 210 KIAA02 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEK :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: gi|109 EVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPAWIKTLWEKSQEK 200 210 220 230 240 250 220 230 240 250 260 270 KIAA02 KITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI :::.:::.:::::::::::::::::::: :. :: :::::.::::::::::::::::::: gi|109 KITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLI 260 270 280 290 300 310 280 290 300 310 320 330 KIAA02 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQ ::::::::::::.:::::::: ::: :::::::::::::::.::: .::.:..::::.: gi|109 VQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAEPRAAVKTVPDTSTPTAQ 320 330 340 350 360 370 340 350 360 370 380 KIAA02 INTI--DSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD .. ... :.:::.:::::.:::.:.. .: .:::: :::::::::.: ::::::::: gi|109 SGSAAAENHRLADVSHISNINGSCVNETMFGSTTSKLECTLENLENLDISMFQAPEDLLD 380 390 400 410 420 430 390 400 410 420 430 440 KIAA02 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH ::::::::::::::::::::::::::::::::::::::::.:::.:...:::.::.:::: gi|109 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIMGDYEDDVRQFWSKSSHRPH 440 450 460 470 480 490 450 460 470 480 490 500 KIAA02 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPS :::::::::::::::.: :: :::::::: :::: ::......:.: ...::::::.:. gi|109 VVGAKWLLECFSKGYILPEESYIHANYQPDGIPVSDQPRNQTTVLEK-SGTFSKKDFVPN 500 510 520 530 540 550 510 520 530 540 550 560 KIAA02 EKHEQADEDLLSQYENGSSTVVEAKTSEA-----RPFNDSTHAEPLNDSTHISLQEENQS :: .:.:::::.:: . .::.:::: ::: : . :.:.:: .::::::.::::.: gi|109 EKFQQTDEDLLAQYVHDDSTIVEAKLSEAIEPEVGPCGGSAHVEPCDDSTHISVQEENKS 560 570 580 590 600 610 570 580 590 600 610 620 KIAA02 SVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAV :::::. : ::. :::::::::::::::: ::: ::.:::.:.::::.:: :: :::::: gi|109 SVSHCLLDGSTVPEEGLFSQKSFLVLGFSVENECNIVNIIREHAGKIVSLPSRIVADYAV 620 630 640 650 660 670 630 640 650 660 670 680 KIAA02 VPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQ ::::::::::::.::::::::::::: ::: ::::::::::: ::.:::::::::::::: gi|109 VPLLGCEVEATVAEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGMTPLEDCVISFSQ 680 690 700 710 720 730 690 700 710 720 730 740 KIAA02 CAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPA :.:::..::.:::: :::::::.:::::::::::.::::::.:: ::::::::::.::: gi|109 CVGAERDSLVFLANHLGASVQEFFVRKSNAKKGMLASTHLIVKEPTGSKYEAAKKWSLPA 740 750 760 770 780 790 750 760 770 780 790 800 KIAA02 VTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRK :.:.::::::: ::::::.:::.... :.:. :::.: ::.. : :. :: ..:. ::. gi|109 VNISWLLETARMGKRADENHFLVDSAPKQEQVLETNIPNGVSPNPDSPAHPDAHLEIHRQ 800 810 820 830 840 850 810 820 830 840 850 860 KIAA02 TVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKP .::::::::::::::.::.::: :: ::: : :: .::::.::::::::::::::::: gi|109 KAVTPLDMNRFQSKAFHAVISQHNRQGLASPPVRQPPKKEPSFHLDTPSKFLSKDKLFKP 860 870 880 890 900 910 870 880 890 900 910 920 KIAA02 SFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQ :::: :::::::::. :: ::: :.:::::::.:: ::::::::. :::::::: :. gi|109 SFDVTDALAALETPNAASQ-KRKLSSPLSEVIVRNLTTALANSSRNTGCLSASPQLKGAH 920 930 940 950 960 970 930 940 950 960 970 980 KIAA02 SEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTN ::::.:::: ::::::::.::::::::::.::::::.:::::::::::.::::: ::.: gi|109 LEKEETPKPLDKVVVCVSKRLSKKQSELNGVAASLGAEYRWSFDETVTHYIYQGRANDSN 980 990 1000 1010 1020 1030 990 1000 1010 1020 1030 1040 KIAA02 REYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLL :::::.::::::.:::::::.:::: :::::::::::::::::::::.:::::::.::: gi|109 REYKSAKERGVHVVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDISTVQDGRLCDSRLP 1040 1050 1060 1070 1080 1090 1050 1060 1070 1080 1090 1100 KIAA02 SAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQL ::.:..:::::: : .::: .....:...::: ::.:..: ::.:::.::::::::::: gi|109 SALSASKDDEPDHLSVEENATETLGTHSRESALLNGNGRDDCKGALTQALEMRENFQKQL 1100 1110 1120 1130 1140 1150 1110 1120 1130 1140 1150 1160 KIAA02 QEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNT ::::::::::. .:.: .:::.:::::::::::::::::::::::::::::: :::.:: gi|109 QEIMSATSIVRTPAQKTCMSRSSCNSASSTPDSTRSARSGRSRVLEALRQSRQIVPDINT 1160 1170 1180 1190 1200 1210 1170 1180 1190 1200 1210 1220 KIAA02 EPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIA :::::::::::::::::::::::::::::: :::::::::.:..:.::: .::.. :::: gi|109 EPSQNEQIIWDDPTAREERARLASNLQWPSYPTQYSELQVEIKKLDDSPSRKPVYHSEIA 1220 1230 1240 1250 1260 1270 1230 1240 1250 1260 1270 1280 KIAA02 KQAVCDPGNIRVTEAP-KHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKI :: : ::.:: .:: ::: :.: . .::: :::::.:::::.:::::.:..:: gi|109 GQASC------VTQAPGQHPGSEEPEAPAAERNLIPEPQAPSVAFPLAKPPVAPQPEDKI 1280 1290 1300 1310 1320 1290 1300 1310 1320 1330 1340 KIAA02 ITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLR :.:::: .:::::.::.:::: :::::::.::. ::: :::::: ::.:::.:::.::: gi|109 ETLEETHGKLKKQYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLR 1330 1340 1350 1360 1370 1380 1350 1360 1370 1380 1390 1400 KIAA02 NEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAA :::::::.::::::::::::.::::::.::::::::::::::::.: .. .:..::::: gi|109 NEKYLASMAAGKWVLHRSYLDACRTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAA 1390 1400 1410 1420 1430 1440 1410 1420 1430 1440 1450 1460 KIAA02 MRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEA :::::.::: .::::.:::::::::::.::. ::::::::::.::::::::: ::::.: gi|109 MRWRKRIQQSRESGIAEGAFSGWKVILRVDRPREAGFKRLLQAGGAKVLPGHPEPLFKDA 1450 1460 1470 1480 1490 1500 1470 1480 1490 1500 1510 1520 KIAA02 THLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQ :::: :.::::::: : ::::.:::. ::.:::::::::.:::: ..:: . :. : gi|109 THLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMMESPPCADNYRVSETALF-- 1510 1520 1530 1540 1550 1560 1530 1540 1550 KIAA02 NNKELGTGLSQKRKAPTEKNKIKRPRVH ::: : :: ::::.:.: : ::::::: gi|109 RNKEGGPGLPQKRKTPAE-NVIKRPRVH 1570 1580 1590 1550 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Wed Mar 4 08:13:53 2009 done: Wed Mar 4 08:18:17 2009 Total Scan time: 2006.130 Total Display time: 1.850 Function used was FASTA [version 34.26.5 April 26, 2007]