hmmpfam - search one or more sequences against HMM database
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file:                 /db/iprscan/data/Pfam.bin
Sequence file:            /db/iprscan/tmp/20080501/iprscan-20080501-16422532/chunk_1/iprscan-20080501-16422532.nocrc
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Query sequence: KIAA0076
Accession:      [none]
Description:    [none]

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PF00888.12.fs Cullin family                                  283.9    2.9e-82   1
PF00888.12.ls Cullin family                                  267.1    3.3e-77   1
PF03256.7.ls Anaphase-promoting complex, subunit 10 (APC1   -67.8     0.0017   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PF03256.7.ls   1/1     815   997 ..     1   222 []   -67.8   0.0017
PF00888.12.ls   1/1    1046  1548 ..     1   656 []   267.1  3.3e-77
PF00888.12.fs   1/1    1165  1548 ..   317   656 .]   283.9  2.9e-82

Alignments of top-scoring domains:
PF03256.7.ls: domain 1 of 1, from 815 to 997: score -67.8, E = 0.0017
                   *->itanatpssrgdlsqkeleGfaevlsqrvreigelAvW...slSScK
                       ++   p           +G         +e+ e   W++  +SS  
    KIAA0076   815    HRPINIPFF-DVFLRYLCQGS-------SVEVKEDKCWekvEVSSNP 853  

                   pGngVlfllRDdnldTyWQSDGsqP.HlvnIqFsKktdIkyvaiYldykl
                   +    l    D+n  TyW S+Gs  +H +    ++   I ++ + + +  
    KIAA0076   854 HRASKL--T-DHNPKTYWESNGSAGsHYITLHMRRGILIRQLTLLVASE- 899  

                   DESYtPskirVraGtgfnDl.qevktleveeGQPtGWVhIplredAGDDG
                   D SY P ++ V  G++++ l++e+  + v     +    + l+       
    KIAA0076   900 DSSYMPARVVVCGGDSTSSLhTELNSVNVMP-SAS---RVILL------- 938  

                   DDVEGGGPNDGGDgreDDkllrvf.mlQiavlaNHqnGrDthvRqIriYg
                                  e  +l+r  + +Qi +   +q G Dt +R+  i+g
    KIAA0076   939 ---------------E--NLTRFWpIIQIRIKRCQQGGIDTRIRGLEILG 971  

                   PviershvphqlfhgNHATptsvdfqtyatl<-*
                   P +    v  +   +      +++f + ++    
    KIAA0076   972 PKPTFWPVFREQLCR-----HTRLFYMVRAQ    997  

PF00888.12.ls: domain 1 of 1, from 1046 to 1548: score 267.1, E = 3.3e-77
                   *->WekLrdaidkilt..nlknfsslsymeLYtaVYnmCtstsavphklg
                      We L + + + +t+++++++s+l +                      
    KIAA0076  1046    WEALVSPVVQNITspDEDGISPLGW---------------------- 1070 

                   ekLYnrLkeyleeyvkalrkslleisddenlLkeyikeWkdfttsmkmin
                                    l++  le+                         
    KIAA0076  1071 -----------------LLDQYLEC------------------------- 1078 

                   difmYLdRyyvkrnidgkkevyeiyeLgLdiWrellfdnikdrlidalLe
                                                   +e +f++           
    KIAA0076  1079 --------------------------------QEAVFNP----------- 1085 

                   lIekeRlGeaidrliknvidmlvsLgldekDmkkqklevYkedFEkpFLe
                                                                     
    KIAA0076     - -------------------------------------------------- -    

                   aTseFYkkesskfLqensvseYmkkvEkrLeeEeeRvrlYLhsstekkLi
                                                                     
    KIAA0076     - -------------------------------------------------- -    

                   evvekvLIekHletLlmehsefqLldnnkieDLrrMYrLlsRvpnGLepl
                                                                  ++ 
    KIAA0076  1086 -----------------------------------------------QSR 1088 

                   rkilekhvkkeGlaavskla..............................
                     ++ ++v++  + +v+ +  + +++   ++++++++++++ ++  +++ 
    KIAA0076  1089 GPAFFSRVRRLTHLLVHVEPceapppvvatprpkgrnrshdwsslatrgl 1138 

                   .........................aetdpkdyVeeLLelhdkydslvne
                   +++  ++ ++  +   +++ ++  + ++ + d+V + +e ++++++  +e
    KIAA0076  1139 pssimrnltrcwravvekqvnnfltSSWRDDDFVPRYCEHFNILQNSSSE 1188 

                   aFnnDplFlnaLdkAfesfiNsnvvtkrskspELLAkYcDdlLKKgs...
                    F+  + Fl aL + + + + +  ++k+++ +E++A+++D+++++++ ++
    KIAA0076  1189 LFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRigg 1238 

                   .KgleeeeleekldkiivlfkyiedKDvFekfYrkmLAkRLLngkSasLd
                    + +e  ++ + + +++++f+ +e  ++Fe++Y++++A+RLL  +S +L+
    KIAA0076  1239 aQEMERLAQLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWLE 1288 

                   daEkrmiskLKqvecGyefTsKLegMfkDislSkelnnsFknhlennndn
                   +a +++i+ +++       ++ ++ M++ +s+Skel+++F+ ++ +++d+
    KIAA0076  1289 GAVLEQIGPCFP-------NRLPQQMLQSLSTSKELQRQFHVYQLQQLDQ 1331 

                   ldlkled...................................eene.E..
                   ++lkled++++ + + + ++++++++++++ +     +  ++ee+e+E++
    KIAA0076  1332 ELLKLEDtekkiqvglgasgkehksekeeeagaaavvdvaegEEEEeEne 1381 

                   .......gidlsvlvLstgfWPtlp.epsin..fnLPeelekalerFeef
                   +   ++ ++++svlvLs+++WP+ + +++ n++ +LP +l+ +l r+++f
    KIAA0076  1382 dlyyegaMPEVSVLVLSRHSWPVASiCHTLNprTCLPSYLRGTLNRYSNF 1431 

                   Ylkkhsgp..d....RkLtWlhsLGkgelkaefndgtkskyeltVstyQm
                   Y+k++s+p  +++++R+L+W++ LG++el++ +       ++l+Vst+Qm
    KIAA0076  1432 YNKSQSHPalErgsqRRLQWTW-LGWAELQFGN-------QTLHVSTVQM 1473 

                   avLLlFNdkeeltyeelqeatqipddeLrrtLqsLlkakvllllllryet
                   ++LL+ Nd + +++e l++  ++++d L++++++L++++++l+l++++++
    KIAA0076  1474 WLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRGPLDLHEQKDI 1523 

                   ig.ekspkdkeispntkfslNsdft<-*
                   +g++ +  d++ +p +++++ + +    
    KIAA0076  1524 PGgVLKIRDGSKEPRSRWDIVRLIP    1548 

PF00888.12.fs: domain 1 of 1, from 1165 to 1548: score 283.9, E = 2.9e-82
                   *->etdpkdyVeeLLelhdkydslvneaFnnDplFlnaLdkAfesfiNsn
                      ++ + d+V + +e ++++++  +e F+  + Fl aL + + + + + 
    KIAA0076  1165    SWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGALLKL 1211 

                   vvtkrskspELLAkYcDdlLKKgs....Kgleeeeleekldkiivlfkyi
                    ++k+++ +E++A+++D+++++++ ++ + +e  ++ + + +++++f+ +
    KIAA0076  1212 PFLKAAHVSEQFARHIDQQIQGSRiggaQEMERLAQLQQCLQAVLIFSGL 1261 

                   edKDvFekfYrkmLAkRLLngkSasLddaEkrmiskLKqvecGyefTsKL
                   e  ++Fe++Y++++A+RLL  +S +L++a +++i+ +++       ++ +
    KIAA0076  1262 EIATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFP-------NRLP 1304 

                   egMfkDislSkelnnsFknhlennndnldlkled................
                   + M++ +s+Skel+++F+ ++ +++d+++lkled++++ + + + +++++
    KIAA0076  1305 QQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDtekkiqvglgasgkeh 1354 

                   ...................eene.E.........gidlsvlvLstgfWPt
                   +++++++ +     +  ++ee+e+E+++   ++ ++++svlvLs+++WP+
    KIAA0076  1355 ksekeeeagaaavvdvaegEEEEeEnedlyyegaMPEVSVLVLSRHSWPV 1404 

                   lp.epsin..fnLPeelekalerFeefYlkkhsgp..d....RkLtWlhs
                    + +++ n++ +LP +l+ +l r+++fY+k++s+p  +++++R+L+W++ 
    KIAA0076  1405 ASiCHTLNprTCLPSYLRGTLNRYSNFYNKSQSHPalErgsqRRLQWTW- 1453 

                   LGkgelkaefndgtkskyeltVstyQmavLLlFNdkeeltyeelqeatqi
                   LG++el++ +       ++l+Vst+Qm++LL+ Nd + +++e l++  ++
    KIAA0076  1454 LGWAELQFGN-------QTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGL 1496 

                   pddeLrrtLqsLlkakvllllllryetig.ekspkdkeispntkfslNsd
                   ++d L++++++L++++++l+l+++++++g++ +  d++ +p +++++ + 
    KIAA0076  1497 SADMLNQAIGPLTSSRGPLDLHEQKDIPGgVLKIRDGSKEPRSRWDIVRL 1546 

                   ft<-*
                   +    
    KIAA0076  1547 IP    1548 

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