BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC146568.7 - phase: 0 
         (703 letters)

Database: uniref100 
           2,790,947 sequences; 848,049,833 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

UniRef100_Q9ZVH4 T2P11.2 protein [Arabidopsis thaliana]              1141  0.0
UniRef100_Q9C9L0 Putative cullin; 66460-68733 [Arabidopsis thali...  1132  0.0
UniRef100_Q6YWY5 Putative cullin 3 [Oryza sativa]                    1091  0.0
UniRef100_Q6YYL1 Putative cullin 3B [Oryza sativa]                   1007  0.0
UniRef100_Q7XJX7 OSJNBa0063C18.16 protein [Oryza sativa]             1006  0.0
UniRef100_Q711G4 Cullin 3B [Arabidopsis thaliana]                     999  0.0
UniRef100_UPI00003AECF4 UPI00003AECF4 UniRef100 entry                 707  0.0
UniRef100_UPI000035F757 UPI000035F757 UniRef100 entry                 702  0.0
UniRef100_Q13618-2 Splice isoform 2 of Q13618 [Homo sapiens]          694  0.0
UniRef100_Q13618 Cullin homolog 3 [Homo sapiens]                      694  0.0
UniRef100_Q6DE95 Cul3-prov protein [Xenopus laevis]                   693  0.0
UniRef100_Q6ZQ84 MKIAA0617 protein [Mus musculus]                     693  0.0
UniRef100_Q9JLV5 Cullin homolog 3 [Mus musculus]                      693  0.0
UniRef100_UPI0000182168 UPI0000182168 UniRef100 entry                 693  0.0
UniRef100_UPI00003AECF2 UPI00003AECF2 UniRef100 entry                 692  0.0
UniRef100_Q6GPF3 MGC80402 protein [Xenopus laevis]                    692  0.0
UniRef100_UPI0000369866 UPI0000369866 UniRef100 entry                 692  0.0
UniRef100_Q6TEL5 Cullin 3 [Brachydanio rerio]                         687  0.0
UniRef100_Q6P0Z1 Cullin 3 [Brachydanio rerio]                         687  0.0
UniRef100_Q13618-3 Splice isoform 3 of Q13618 [Homo sapiens]          662  0.0

>UniRef100_Q9ZVH4 T2P11.2 protein [Arabidopsis thaliana]
          Length = 732

 Score = 1141 bits (2952), Expect = 0.0
 Identities = 553/680 (81%), Positives = 621/680 (91%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHLKEIAKSIEAAQGGSFLEELNRKWNDHNKALQM 83
           +RNAYNMVLHKFG++LY+G +ATMT+HLKE +K IEAAQGGSFLEELN+KWN+HNKAL+M
Sbjct: 53  YRNAYNMVLHKFGEKLYTGFIATMTSHLKEKSKLIEAAQGGSFLEELNKKWNEHNKALEM 112

Query: 84  IRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEVI 143
           IRDILMYMDRT+I S KKT VH +GLNLWR++V++  +I TRLLNTLL+LVQ ER GEVI
Sbjct: 113 IRDILMYMDRTYIESTKKTHVHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVI 172

Query: 144 DRGIMRNITKMLMDLGPAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKAERRL 203
           DRG+MRN+ KM MDLG +VY +DFE  FL  S+EFY+VESQ FIE CDCGDYLKK+E+RL
Sbjct: 173 DRGLMRNVIKMFMDLGESVYQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRL 232

Query: 204 NEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLGRMYN 263
            EE++RV HY+D ++E+KI  VVE +MI NHM RL+HMENSGLVNML +DKYEDLGRMYN
Sbjct: 233 TEEIERVAHYLDAKSEEKITSVVEKEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYN 292

Query: 264 LFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIINQAFN 323
           LFRRV +GL+ +R+VMT H+RE GKQLVTDPE+ KDPVEFVQRLLDE+DKYDKIIN AF 
Sbjct: 293 LFRRVTNGLVTVRDVMTSHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDKIINTAFG 352

Query: 324 NDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMMLFRY 383
           NDK+FQNALNSSFEYFINLN RSPEFISLFVDDKLRKGLKG+ + DVEV LDKVMMLFRY
Sbjct: 353 NDKTFQNALNSSFEYFINLNARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRY 412

Query: 384 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSQ 443
           LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTS+
Sbjct: 413 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSE 472

Query: 444 DTMQGFYASHPDLGDGPTLTVQVLTTGSWPTQSSITCNLPVEISALCEKFRSYYLGTHTG 503
           DTM+GFY SHP+L +GPTL VQVLTTGSWPTQ ++ CNLP E+S LCEKFRSYYLGTHTG
Sbjct: 473 DTMRGFYGSHPELSEGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTG 532

Query: 504 RRLSWQTNMGFADLKATFGKGQKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAPD 563
           RRLSWQTNMG AD+KA FGKGQKHELNVST+QMCVLMLFNN+D+LSYKEIEQATEIPA D
Sbjct: 533 RRLSWQTNMGTADIKAIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAAD 592

Query: 564 LKRCLQSLALVKGRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVAQKESEPEK 623
           LKRCLQSLA VKG+NV++KEPMSKD+GE+D F VNDKF+SK YKVKIGTVVAQKE+EPEK
Sbjct: 593 LKRCLQSLACVKGKNVIKKEPMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETEPEK 652

Query: 624 QETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIESL 683
           QETRQRVEEDRKPQIEAAIVRIMKSR++LDHNN+IAEVTKQLQ RFLANPTE+KKRIESL
Sbjct: 653 QETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESL 712

Query: 684 IERDFLERDDNDRKMYRYLA 703
           IERDFLERD  DRK+YRYLA
Sbjct: 713 IERDFLERDSTDRKLYRYLA 732


>UniRef100_Q9C9L0 Putative cullin; 66460-68733 [Arabidopsis thaliana]
          Length = 732

 Score = 1132 bits (2928), Expect = 0.0
 Identities = 550/680 (80%), Positives = 621/680 (90%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHLKEIAKSIEAAQGGSFLEELNRKWNDHNKALQM 83
           +RNAYNMVLHK+GD+LY+GLV TMT HLKEI KSIE AQGG+FLE LNRKWNDHNKALQM
Sbjct: 53  YRNAYNMVLHKYGDKLYTGLVTTMTFHLKEICKSIEEAQGGAFLELLNRKWNDHNKALQM 112

Query: 84  IRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEVI 143
           IRDILMYMDRT++ + KKT VHELGL+LWR++V+YS++I+TRLLNTLL+LV  ERTGEVI
Sbjct: 113 IRDILMYMDRTYVSTTKKTHVHELGLHLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVI 172

Query: 144 DRGIMRNITKMLMDLGPAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKAERRL 203
           DR +MRN+ KM MDLG +VY  DFE  FL+ SAEFY+VES  FIE CDCG+YLKKAE+ L
Sbjct: 173 DRVLMRNVIKMFMDLGESVYQDDFEKPFLEASAEFYKVESMEFIESCDCGEYLKKAEKPL 232

Query: 204 NEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLGRMYN 263
            EE++RV +Y+D ++E KI  VVE +MI NH+ RL+HMENSGLVNML +DKYED+GRMY+
Sbjct: 233 VEEVERVVNYLDAKSEAKITSVVEREMIANHVQRLVHMENSGLVNMLLNDKYEDMGRMYS 292

Query: 264 LFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIINQAFN 323
           LFRRVA+GL+ +R+VMTLH+RE GKQLVTDPE+ KDPVEFVQRLLDE+DKYD+IIN AFN
Sbjct: 293 LFRRVANGLVTVRDVMTLHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDRIINMAFN 352

Query: 324 NDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMMLFRY 383
           NDK+FQNALNSSFEYF+NLN RSPEFISLFVDDKLRKGLKGV E+DV++ LDKVMMLFRY
Sbjct: 353 NDKTFQNALNSSFEYFVNLNTRSPEFISLFVDDKLRKGLKGVGEEDVDLILDKVMMLFRY 412

Query: 384 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSQ 443
           LQEKDVFEKYYKQHLAKRLLSGKTVSDDAER+LIVKLKTECGYQFTSKLEGMFTDMKTS 
Sbjct: 413 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERNLIVKLKTECGYQFTSKLEGMFTDMKTSH 472

Query: 444 DTMQGFYASHPDLGDGPTLTVQVLTTGSWPTQSSITCNLPVEISALCEKFRSYYLGTHTG 503
           DT+ GFY SHP+L +GPTL VQVLTTGSWPTQ +I CNLP E+S LCEKFRSYYLGTHTG
Sbjct: 473 DTLLGFYNSHPELSEGPTLVVQVLTTGSWPTQPTIQCNLPAEVSVLCEKFRSYYLGTHTG 532

Query: 504 RRLSWQTNMGFADLKATFGKGQKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAPD 563
           RRLSWQTNMG AD+KA FGKGQKHELNVST+QMCVLMLFNN+D+LSYKEIEQATEIP PD
Sbjct: 533 RRLSWQTNMGTADIKAVFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPD 592

Query: 564 LKRCLQSLALVKGRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVAQKESEPEK 623
           LKRCLQS+A VKG+NVLRKEPMSK++ E+D F VND+F+SK YKVKIGTVVAQKE+EPEK
Sbjct: 593 LKRCLQSMACVKGKNVLRKEPMSKEIAEEDWFVVNDRFASKFYKVKIGTVVAQKETEPEK 652

Query: 624 QETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIESL 683
           QETRQRVEEDRKPQIEAAIVRIMKSRR+LDHNN+IAEVTKQLQ RFLANPTE+KKRIESL
Sbjct: 653 QETRQRVEEDRKPQIEAAIVRIMKSRRVLDHNNIIAEVTKQLQTRFLANPTEIKKRIESL 712

Query: 684 IERDFLERDDNDRKMYRYLA 703
           IERDFLERD+ DRK+YRYLA
Sbjct: 713 IERDFLERDNTDRKLYRYLA 732


>UniRef100_Q6YWY5 Putative cullin 3 [Oryza sativa]
          Length = 736

 Score = 1091 bits (2822), Expect = 0.0
 Identities = 540/681 (79%), Positives = 602/681 (88%), Gaps = 1/681 (0%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHLKEIAKSIEAAQGGSFLEELNRKWNDHNKALQM 83
           +R+AYNMVLHK+G++LY GL  TMT  LKEI+KSIEAAQGG FLEELN KW DHNKALQM
Sbjct: 56  YRSAYNMVLHKYGEKLYDGLERTMTWRLKEISKSIEAAQGGLFLEELNAKWMDHNKALQM 115

Query: 84  IRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEVI 143
           IRDILMYMDRT++P +++TPVHELGLNLWR+ +I+S  I +RLL+TLL+L+  ER GE+I
Sbjct: 116 IRDILMYMDRTYVPQSRRTPVHELGLNLWRDHIIHSPMIHSRLLDTLLDLIHRERMGEMI 175

Query: 144 DRGIMRNITKMLMDLGPAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKAERRL 203
           +RG+MR+ITKMLMDLG AVY  DFE  FL V+A FY  ESQ FIECCDCG+YLKK+ERRL
Sbjct: 176 NRGLMRSITKMLMDLGAAVYQDDFEKPFLDVTASFYSGESQEFIECCDCGNYLKKSERRL 235

Query: 204 NEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLGRMYN 263
           NEEM+RV HY+D  TE KI  VVE +MI NHM RL+HMENSGLVNML DDKY+DL RMYN
Sbjct: 236 NEEMERVSHYLDSGTEAKITSVVEKEMIANHMHRLVHMENSGLVNMLVDDKYDDLARMYN 295

Query: 264 LFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIINQAFN 323
           LFRRV DGL  IR+VMT ++RE+GKQLVTDPERLKDPVEFVQRLL+EKDK+DKIIN AF 
Sbjct: 296 LFRRVFDGLSTIRDVMTSYLRETGKQLVTDPERLKDPVEFVQRLLNEKDKHDKIINVAFG 355

Query: 324 NDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMMLFRY 383
           NDK+FQNALNSSFEYFINLN RSPEFISL+VDDKLRKGLKG  E+DVEV LDKVMMLFRY
Sbjct: 356 NDKTFQNALNSSFEYFINLNNRSPEFISLYVDDKLRKGLKGATEEDVEVILDKVMMLFRY 415

Query: 384 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSQ 443
           LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERS+IVKLKTECGYQFTSKLEGMFTDMKTSQ
Sbjct: 416 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSMIVKLKTECGYQFTSKLEGMFTDMKTSQ 475

Query: 444 DTMQGFYA-SHPDLGDGPTLTVQVLTTGSWPTQSSITCNLPVEISALCEKFRSYYLGTHT 502
           DTM  FYA    +LGDGPTL V +LTTGSWPTQ    CNLP EI A+C+KFR+YYLGTH+
Sbjct: 476 DTMIDFYAKKSEELGDGPTLDVHILTTGSWPTQPCPPCNLPTEILAICDKFRTYYLGTHS 535

Query: 503 GRRLSWQTNMGFADLKATFGKGQKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAP 562
           GRRL+WQTNMG AD+KATFGKGQKHELNVSTYQMCVLMLFN+ D L+YK+IEQ T IPA 
Sbjct: 536 GRRLTWQTNMGTADIKATFGKGQKHELNVSTYQMCVLMLFNSTDGLTYKDIEQDTAIPAS 595

Query: 563 DLKRCLQSLALVKGRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVAQKESEPE 622
           DLKRCLQSLA VKG+NVLRKEPMSKD+ EDD F  NDKF+SKL KVKIGTVVAQKESEPE
Sbjct: 596 DLKRCLQSLACVKGKNVLRKEPMSKDISEDDTFYFNDKFTSKLVKVKIGTVVAQKESEPE 655

Query: 623 KQETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIES 682
           KQETRQRVEEDRKPQIEAAIVRIMKSRR+LDHN+++AEVTKQLQ RF+ NP  +KKRIES
Sbjct: 656 KQETRQRVEEDRKPQIEAAIVRIMKSRRVLDHNSIVAEVTKQLQARFMPNPVVIKKRIES 715

Query: 683 LIERDFLERDDNDRKMYRYLA 703
           LIER+FLERD  DRK+YRYLA
Sbjct: 716 LIEREFLERDKADRKLYRYLA 736


>UniRef100_Q6YYL1 Putative cullin 3B [Oryza sativa]
          Length = 731

 Score = 1007 bits (2604), Expect = 0.0
 Identities = 492/680 (72%), Positives = 573/680 (83%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHLKEIAKSIEAAQGGSFLEELNRKWNDHNKALQM 83
           +R AYN+VLHK G +LY  L   M  HL+E+  SIEAAQGG FL EL RKW+DHNKALQM
Sbjct: 52  YRTAYNLVLHKHGPKLYDKLTENMEDHLQEMRVSIEAAQGGLFLVELQRKWDDHNKALQM 111

Query: 84  IRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEVI 143
           IRDILMYMDR FIP+ KKTPV +LGL+LWR++++ S +I  RLL+TLL+L+  ERTGEVI
Sbjct: 112 IRDILMYMDRVFIPTNKKTPVFDLGLDLWRDTIVRSPKIHGRLLDTLLDLIHRERTGEVI 171

Query: 144 DRGIMRNITKMLMDLGPAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKAERRL 203
           +R +MR+ TKMLMDLG +VY  DFE  FL+VSA FY  ESQ+FIECC CG+YLKKA++RL
Sbjct: 172 NRSLMRSTTKMLMDLGSSVYQDDFERPFLEVSASFYSGESQKFIECCSCGEYLKKAQQRL 231

Query: 204 NEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLGRMYN 263
           +EE +RV  YMD +T++KI  VV  +M+ NHM RLI MENSGLVNML +DKYEDL  MY+
Sbjct: 232 DEEAERVSQYMDAKTDEKITAVVVKEMLANHMQRLILMENSGLVNMLVEDKYEDLTMMYS 291

Query: 264 LFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIINQAFN 323
           LF+RV DG   I+ VM  H++E+GK +V DPERLKDPV+FVQRLL+EKDKYD I+  +F+
Sbjct: 292 LFQRVPDGHSTIKSVMNSHVKETGKDMVMDPERLKDPVDFVQRLLNEKDKYDSIVTTSFS 351

Query: 324 NDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMMLFRY 383
           NDKSFQNALNSSFE+FINLN R PEFISL+VDDKLRKG+K  NE+DVE  LDKVMMLFRY
Sbjct: 352 NDKSFQNALNSSFEHFINLNNRCPEFISLYVDDKLRKGMKEANEEDVETVLDKVMMLFRY 411

Query: 384 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSQ 443
           LQEKD+FEKYYKQHLAKRLLSGK  SDD+ERS++VKLKTECGYQFTSKLEGMF D+KTS 
Sbjct: 412 LQEKDLFEKYYKQHLAKRLLSGKAASDDSERSMLVKLKTECGYQFTSKLEGMFNDLKTSH 471

Query: 444 DTMQGFYASHPDLGDGPTLTVQVLTTGSWPTQSSITCNLPVEISALCEKFRSYYLGTHTG 503
           DT Q FYA  PDLGD PT++VQ+LTTGSWPTQ   TCNLP EI  + E FR +YLGTH G
Sbjct: 472 DTTQRFYAGTPDLGDAPTISVQILTTGSWPTQPCNTCNLPPEILGVSEMFRGFYLGTHNG 531

Query: 504 RRLSWQTNMGFADLKATFGKGQKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAPD 563
           RRL+WQTNMG AD+KA FG G KHELNVSTYQMCVLMLFN+AD LSY++IEQ T IP+ D
Sbjct: 532 RRLTWQTNMGTADIKAVFGNGSKHELNVSTYQMCVLMLFNSADCLSYRDIEQTTAIPSAD 591

Query: 564 LKRCLQSLALVKGRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVAQKESEPEK 623
           LKRCLQSLALVKG+NVLRKEPMS+D+ +DD F VNDKF+SKL+KVKIGTV  QKESEPEK
Sbjct: 592 LKRCLQSLALVKGKNVLRKEPMSRDISDDDNFYVNDKFTSKLFKVKIGTVATQKESEPEK 651

Query: 624 QETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIESL 683
            ETRQRVEEDRKPQIEAAIVRIMKSRR+LDHN+++ EVTKQLQ RF+ NP  +KKR+ESL
Sbjct: 652 METRQRVEEDRKPQIEAAIVRIMKSRRVLDHNSIVTEVTKQLQPRFMPNPVVIKKRVESL 711

Query: 684 IERDFLERDDNDRKMYRYLA 703
           IER+FLERD  DRK+YRYLA
Sbjct: 712 IEREFLERDKTDRKLYRYLA 731


>UniRef100_Q7XJX7 OSJNBa0063C18.16 protein [Oryza sativa]
          Length = 731

 Score = 1006 bits (2602), Expect = 0.0
 Identities = 504/680 (74%), Positives = 575/680 (84%), Gaps = 1/680 (0%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHLKEIAKSIEAAQGGSFLEELNRKWNDHNKALQM 83
           +R AYN+VLHK G +LY  L   +  HLKE+ +SIE AQG  FLEEL R+W DHNKALQM
Sbjct: 53  YRTAYNLVLHKHGLKLYDKLTENLKGHLKEMCRSIEDAQGSLFLEELQRRWADHNKALQM 112

Query: 84  IRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEVI 143
           IRDILMYMDRTFI + KKTPV +LGL LWR+ V+ + +I  RLL+TLLEL+  ER GE+I
Sbjct: 113 IRDILMYMDRTFIATNKKTPVFDLGLELWRDIVVRTPKIHGRLLDTLLELIHRERMGEMI 172

Query: 144 DRGIMRNITKMLMDLGPAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKAERRL 203
           +RG+MR+ TKMLMDLG +VY  DFE  FL+VSA FY  ESQ+FIECCDCG+YLKKAERRL
Sbjct: 173 NRGLMRSTTKMLMDLGSSVYHDDFEKPFLEVSASFYSGESQQFIECCDCGEYLKKAERRL 232

Query: 204 NEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLGRMYN 263
            EE++RV  YMD +T  KI  VV+T+M+ NHM RLI MENSGLVNML DDK+EDL RMYN
Sbjct: 233 AEELERVSQYMDAKTADKITSVVDTEMLANHMQRLILMENSGLVNMLVDDKHEDLSRMYN 292

Query: 264 LFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIINQAFN 323
           LF+RV DG   IR VM  H++ESGK LV+DPE++KDPVEFVQRLL+EKDKYD+II+ +F+
Sbjct: 293 LFKRVPDGHSTIRSVMASHVKESGKALVSDPEKIKDPVEFVQRLLNEKDKYDEIISISFS 352

Query: 324 NDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMMLFRY 383
           NDK+FQNALNSSFE FINLN RSPEFISLFVDDKLRKG+KG NE+DVE  LDKVMMLFRY
Sbjct: 353 NDKAFQNALNSSFENFINLNNRSPEFISLFVDDKLRKGVKGANEEDVETVLDKVMMLFRY 412

Query: 384 LQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSQ 443
           LQEKDVFEKYYKQHLAKRLLSGKT SD+AERS++VKLKTECGYQFTSKLEGMF D+KTS 
Sbjct: 413 LQEKDVFEKYYKQHLAKRLLSGKTTSDEAERSMLVKLKTECGYQFTSKLEGMFNDLKTSH 472

Query: 444 DTMQGFYASHPDLGDGPTLTVQVLTTGSWPTQSSITCNLPVEISALCEKFRSYYLGTHTG 503
           DTMQ FYA+     D PT++VQ+LTTGSWPTQ    C LP EI  + EKFR++YLGTH G
Sbjct: 473 DTMQSFYANLSGDTDSPTISVQILTTGSWPTQPCTPCKLPPEIVDISEKFRAFYLGTHNG 532

Query: 504 RRLSWQTNMGFADLKATFGKGQKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAPD 563
           RRL+WQTNMG AD+KATFG G++HELNVSTYQMCVLMLFN+AD L+Y +IEQAT IP  D
Sbjct: 533 RRLTWQTNMGNADIKATFG-GRRHELNVSTYQMCVLMLFNSADGLTYGDIEQATGIPHAD 591

Query: 564 LKRCLQSLALVKGRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVAQKESEPEK 623
           LKRCLQSLA VKG+NVLRKEPMSKD+ EDD F  NDKF+SKL KVKIGTVVAQKE+EPEK
Sbjct: 592 LKRCLQSLACVKGKNVLRKEPMSKDISEDDTFYYNDKFTSKLVKVKIGTVVAQKETEPEK 651

Query: 624 QETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIESL 683
            ETRQRVEEDRKPQIEAAIVRIMKSRR+LDHN++I EVTKQLQ RFL NP  +KKRIESL
Sbjct: 652 LETRQRVEEDRKPQIEAAIVRIMKSRRVLDHNSIITEVTKQLQSRFLPNPVVIKKRIESL 711

Query: 684 IERDFLERDDNDRKMYRYLA 703
           IER+FLERD  DRKMYRYLA
Sbjct: 712 IEREFLERDKVDRKMYRYLA 731


>UniRef100_Q711G4 Cullin 3B [Arabidopsis thaliana]
          Length = 601

 Score =  999 bits (2583), Expect = 0.0
 Identities = 486/600 (81%), Positives = 549/600 (91%)

Query: 104 VHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEVIDRGIMRNITKMLMDLGPAVY 163
           VHELGL+LWR++V+YS++I+TRLLNTLL+LV  ERTGEVIDR +MRN+ KM MDLG +VY
Sbjct: 2   VHELGLHLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVIDRVLMRNVIKMFMDLGESVY 61

Query: 164 GQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKAERRLNEEMDRVGHYMDPETEKKIN 223
             DFE  FL+ SAEFY+VES  FIE CDCG+YLKKAE+ L EE++RV +Y+D ++E KI 
Sbjct: 62  QDDFEKPFLEASAEFYKVESMEFIESCDCGEYLKKAEKPLVEEVERVVNYLDAKSEAKIT 121

Query: 224 KVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLGRMYNLFRRVADGLLKIREVMTLHI 283
            VVE +MI NH+ RL+HMENSGLVNML +DKYED+GRMY+LFRRVA+GL+ +R+VMTLH+
Sbjct: 122 SVVEREMIANHVQRLVHMENSGLVNMLLNDKYEDMGRMYSLFRRVANGLVTVRDVMTLHL 181

Query: 284 RESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIINQAFNNDKSFQNALNSSFEYFINLN 343
           RE GKQLVTDPE+ KDPVEFVQRLLDE+DKYD+IIN AFNNDK+FQNALNSSFEYF+NLN
Sbjct: 182 REMGKQLVTDPEKSKDPVEFVQRLLDERDKYDRIINMAFNNDKTFQNALNSSFEYFVNLN 241

Query: 344 PRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMMLFRYLQEKDVFEKYYKQHLAKRLL 403
            RSPEFISLFVDDKLRKGLKGV E+DV++ LDKVMMLFRYLQEKDVFEKYYKQHLAKRLL
Sbjct: 242 TRSPEFISLFVDDKLRKGLKGVGEEDVDLILDKVMMLFRYLQEKDVFEKYYKQHLAKRLL 301

Query: 404 SGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSQDTMQGFYASHPDLGDGPTLT 463
           SGKTVSDDAER+LIVKLKTECGYQFTSKLEGMFTDMKTS DT+ GFY SHP+L +GPTL 
Sbjct: 302 SGKTVSDDAERNLIVKLKTECGYQFTSKLEGMFTDMKTSHDTLLGFYNSHPELSEGPTLV 361

Query: 464 VQVLTTGSWPTQSSITCNLPVEISALCEKFRSYYLGTHTGRRLSWQTNMGFADLKATFGK 523
           VQVLTTGSWPTQ +I CNLP E+S LCEKFRSYYLGTHTGRRLSWQTNMG AD+KA FGK
Sbjct: 362 VQVLTTGSWPTQPTIQCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAVFGK 421

Query: 524 GQKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVKGRNVLRKE 583
           GQKHELNVST+QMCVLMLFNN+D+LSYKEIEQATEIP PDLKRCLQS+A VKG+NVLRKE
Sbjct: 422 GQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPDLKRCLQSMACVKGKNVLRKE 481

Query: 584 PMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVAQKESEPEKQETRQRVEEDRKPQIEAAIV 643
           PMSK++ E+D F VND+F+SK YKVKIGTVVAQKE+EPEKQETRQRVEEDRKPQIEAAIV
Sbjct: 482 PMSKEIAEEDWFVVNDRFASKFYKVKIGTVVAQKETEPEKQETRQRVEEDRKPQIEAAIV 541

Query: 644 RIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           RIMKSRR+LDHNN+IAEVTKQLQ RFLANPTE+KKRIESLIERDFLERD+ DRK+YRYLA
Sbjct: 542 RIMKSRRVLDHNNIIAEVTKQLQTRFLANPTEIKKRIESLIERDFLERDNTDRKLYRYLA 601


>UniRef100_UPI00003AECF4 UPI00003AECF4 UniRef100 entry
          Length = 719

 Score =  707 bits (1825), Expect = 0.0
 Identities = 369/688 (53%), Positives = 499/688 (71%), Gaps = 9/688 (1%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 33  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 92

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 93  MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 152

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 153 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 212

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 213 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 272

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 273 CMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 332

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 333 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 392

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 393 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 452

Query: 440 KTSQDTMQGFYASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFRSYYL 498
             S  TM  F  S  D G G  LTV+VLTTG WPTQS+   CN+P       E FR +YL
Sbjct: 453 SISNTTMDEFATSSVDWG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL 511

Query: 499 GTHTGRRLSWQTNMGFADLKATF-GKGQKHELNVSTYQMCVLMLFNNADKLSYKEIEQAT 557
             H+GR+L+ Q +MG ADL ATF G  +KH L VST+QM +LMLFNN +K +++EI+Q T
Sbjct: 512 AKHSGRQLTLQHHMGSADLNATFYGPVKKHILQVSTFQMTILMLFNNREKYTFEEIQQET 571

Query: 558 EIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVA- 615
           +IP  +L R LQSLA  K  + VL KEP SK++     F+VND+F+SKL++VKI TV A 
Sbjct: 572 DIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAK 631

Query: 616 QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTE 675
           Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ + HN L+AEVT+QL+ RFL +P  
Sbjct: 632 QGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVV 691

Query: 676 VKKRIESLIERDFLERDDNDRKMYRYLA 703
           +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 692 IKKRIEGLIEREYLARTPEDRKVYTYVA 719


>UniRef100_UPI000035F757 UPI000035F757 UniRef100 entry
          Length = 727

 Score =  702 bits (1813), Expect = 0.0
 Identities = 369/692 (53%), Positives = 498/692 (71%), Gaps = 12/692 (1%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 36  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 95

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 96  MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 155

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 156 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENCASVYIKKV 215

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 216 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKIEDLA 275

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+L++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 276 CMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLL 335

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KGLKG+ E +VE  LDK M+
Sbjct: 336 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGLKGLTEQEVESILDKAMV 395

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 396 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 455

Query: 440 KTSQDTMQGFYASHPDLGDGP---TLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFRS 495
             S  TM  F       G  P    LTV+VLTTG WPTQS+   CN+P       E FR 
Sbjct: 456 TISNTTMDEFRQHLQTTGVSPGGVDLTVRVLTTGYWPTQSATPKCNIPHSPRHAFEVFRR 515

Query: 496 YYLGTHTGRRLSWQTNMGFADLKATF--GKGQKHELNVSTYQMCVLMLFNNADKLSYKEI 553
           +YLG H+GR+L+ Q +MG ADL ATF     +KH L VST+QM +LMLFNN +K +++EI
Sbjct: 516 FYLGKHSGRQLTLQHHMGSADLNATFTGPSERKHILQVSTFQMTILMLFNNREKFTFEEI 575

Query: 554 EQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGT 612
           +Q T+IP  +L R LQSLA  K  + VL KEP SK++     F+VND+F+SKL++VKI T
Sbjct: 576 QQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHVFTVNDQFTSKLHRVKIQT 635

Query: 613 VVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLA 671
           V A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ + HN L+AEVT+QL+ RFL 
Sbjct: 636 VAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLP 695

Query: 672 NPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 696 SPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 727


>UniRef100_Q13618-2 Splice isoform 2 of Q13618 [Homo sapiens]
          Length = 744

 Score =  694 bits (1791), Expect = 0.0
 Identities = 371/712 (52%), Positives = 502/712 (70%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 34  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 93

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 94  MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 153

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 154 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 213

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDLG
Sbjct: 214 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLG 273

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 274 CMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLL 333

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 334 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 393

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 394 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 453

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F     A+   LG G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 454 SISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 512

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 513 RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVST 572

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 573 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG 632

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 633 HIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 692

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 693 MQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 744


>UniRef100_Q13618 Cullin homolog 3 [Homo sapiens]
          Length = 768

 Score =  694 bits (1791), Expect = 0.0
 Identities = 371/712 (52%), Positives = 502/712 (70%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDLG
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLG 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLL 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F     A+   LG G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 478 SISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 536

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVST 596

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 597 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG 656

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 657 HIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 716

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 717 MQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_Q6DE95 Cul3-prov protein [Xenopus laevis]
          Length = 768

 Score =  693 bits (1789), Expect = 0.0
 Identities = 369/711 (51%), Positives = 499/711 (69%), Gaps = 31/711 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+L++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++F+ND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGFYASHPDLG---DGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFRS 495
             S  TM  F       G    G  LTV+VLTTG WPTQS+   CN+P       E FR 
Sbjct: 478 SISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRR 537

Query: 496 YYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVSTY 534
           +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST+
Sbjct: 538 FYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTF 597

Query: 535 QMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGEDD 593
           QM +LMLFNN DK +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++    
Sbjct: 598 QMTILMLFNNRDKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGH 657

Query: 594 AFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRLL 652
            F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ +
Sbjct: 658 MFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKM 717

Query: 653 DHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
            HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 718 QHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_Q6ZQ84 MKIAA0617 protein [Mus musculus]
          Length = 792

 Score =  693 bits (1789), Expect = 0.0
 Identities = 370/712 (51%), Positives = 501/712 (69%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 82  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 141

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 142 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 201

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 202 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 261

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 262 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 321

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 322 CMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 381

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 382 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 441

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 442 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 501

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F     A+   LG G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 502 SISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 560

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 561 RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVST 620

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 621 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG 680

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 681 HIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 740

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 741 MQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 792


>UniRef100_Q9JLV5 Cullin homolog 3 [Mus musculus]
          Length = 768

 Score =  693 bits (1789), Expect = 0.0
 Identities = 370/712 (51%), Positives = 501/712 (69%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F     A+   LG G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 478 SISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 536

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVST 596

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 597 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG 656

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 657 HIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 716

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 717 MQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_UPI0000182168 UPI0000182168 UniRef100 entry
          Length = 768

 Score =  693 bits (1788), Expect = 0.0
 Identities = 370/712 (51%), Positives = 501/712 (69%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F     A+   LG G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 478 SISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 536

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVST 596

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 597 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG 656

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 657 HIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 716

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 717 MQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_UPI00003AECF2 UPI00003AECF2 UniRef100 entry
          Length = 768

 Score =  692 bits (1787), Expect = 0.0
 Identities = 368/711 (51%), Positives = 498/711 (69%), Gaps = 31/711 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGFYASHPDLG---DGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFRS 495
             S  TM  F       G    G  LTV+VLTTG WPTQS+   CN+P       E FR 
Sbjct: 478 SISNTTMDEFRQHLQSTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRR 537

Query: 496 YYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVSTY 534
           +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST+
Sbjct: 538 FYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTF 597

Query: 535 QMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGEDD 593
           QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++    
Sbjct: 598 QMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGH 657

Query: 594 AFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRLL 652
            F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ +
Sbjct: 658 IFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKM 717

Query: 653 DHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
            HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 718 QHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_Q6GPF3 MGC80402 protein [Xenopus laevis]
          Length = 768

 Score =  692 bits (1786), Expect = 0.0
 Identities = 368/711 (51%), Positives = 499/711 (69%), Gaps = 31/711 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+L++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSLYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++F+ND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFSNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGFYASHPDLG---DGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFRS 495
             S  TM  F       G    G  LTV+VLTTG WPTQS+   CN+P       E FR 
Sbjct: 478 SISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEIFRR 537

Query: 496 YYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVSTY 534
           +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST+
Sbjct: 538 FYLAKHSGRQLTLQHHMGSADLNATFYGAVKKEDGSEVGVGGAQVTGSNTRKHILQVSTF 597

Query: 535 QMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGEDD 593
           QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++    
Sbjct: 598 QMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGH 657

Query: 594 AFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRLL 652
            F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ +
Sbjct: 658 MFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKM 717

Query: 653 DHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
            HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 718 QHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_UPI0000369866 UPI0000369866 UniRef100 entry
          Length = 768

 Score =  692 bits (1785), Expect = 0.0
 Identities = 370/712 (51%), Positives = 501/712 (69%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 58  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMV 117

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 118 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 177

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 178 VDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKV 237

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDLG
Sbjct: 238 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLG 297

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 298 CMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLL 357

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 358 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMV 417

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 418 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 477

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F     A+   LG G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 478 SISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFR 536

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 537 RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVST 596

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 597 FQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENG 656

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 657 HIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 716

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AE T+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 717 MQHNVLVAEETQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768


>UniRef100_Q6TEL5 Cullin 3 [Brachydanio rerio]
          Length = 766

 Score =  687 bits (1774), Expect = 0.0
 Identities = 368/712 (51%), Positives = 497/712 (69%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 56  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLHSLNNNFLQTLNQAWNDHQTAMV 115

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 116 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEV 175

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFE  FL +SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 176 VDRGAIRNACQMLMVLGLKGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSASVYIKKV 235

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 236 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 295

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 296 CMYKLFGRVPNGLKTMCECMSWYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 355

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 356 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMV 415

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 416 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 475

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F      S   L  G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 476 SISNTTMDEFRHHLQTSQVSL-CGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFR 534

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 535 RFYLAKHSGRQLTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALLTGSNTRKHILQVST 594

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 595 FQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG 654

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 655 HVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 714

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 715 MQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766


>UniRef100_Q6P0Z1 Cullin 3 [Brachydanio rerio]
          Length = 766

 Score =  687 bits (1774), Expect = 0.0
 Identities = 368/712 (51%), Positives = 497/712 (69%), Gaps = 33/712 (4%)

Query: 24  FRNAYNMVLHKFGDRLYSGLVATMTAHL-KEIAKSIEAAQGGSFLEELNRKWNDHNKALQ 82
           +RNAY MVLHK G++LY+GL   +T HL  ++ + +  +   +FL+ LN+ WNDH  A+ 
Sbjct: 56  YRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLHSLNNNFLQTLNQAWNDHQTAMV 115

Query: 83  MIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRTRLLNTLLELVQSERTGEV 142
           MIRDILMYMDR ++       V+ LGL ++R+ V+    IR  L  TLL+++  ER GEV
Sbjct: 116 MIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERRGEV 175

Query: 143 IDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQVESQRFIECCDCGDYLKKA 199
           +DRG +RN  +MLM LG    +VY +DFE  FL +SAEF+Q+ESQ+F+       Y+KK 
Sbjct: 176 VDRGAIRNACQMLMVLGLEGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSASVYIKKV 235

Query: 200 ERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHMENSGLVNMLCDDKYEDLG 259
           E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ MENSGLV+ML + K EDL 
Sbjct: 236 EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLA 295

Query: 260 RMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPVEFVQRLLDEKDKYDKIIN 319
            MY LF RV +GL  + E M+ ++RE GK LV++    K+PV+++Q LLD K ++D+ + 
Sbjct: 296 CMYKLFGRVPNGLKTMCECMSWYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQ 355

Query: 320 QAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKGLKGVNEDDVEVTLDKVMM 379
           ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG+KG+ E +VE  LDK M+
Sbjct: 356 ESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMV 415

Query: 380 LFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDM 439
           LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLKTECG QFTSKLEGMF DM
Sbjct: 416 LFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDM 475

Query: 440 KTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSSI-TCNLPVEISALCEKFR 494
             S  TM  F      S   L  G  LTV+VLTTG WPTQS+   CN+P       E FR
Sbjct: 476 SISNTTMDEFRHHLQTSQVSL-CGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFR 534

Query: 495 SYYLGTHTGRRLSWQTNMGFADLKATF------------GKG---------QKHELNVST 533
            +YL  H+GR+L+ Q +MG ADL ATF            G G         +KH L VST
Sbjct: 535 RFYLAKHSGRQLTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALLTGSNTRKHILQVST 594

Query: 534 YQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK-GRNVLRKEPMSKDVGED 592
           +QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K  + VL KEP SK++   
Sbjct: 595 FQMTILMLFNNREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESG 654

Query: 593 DAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEEDRKPQIEAAIVRIMKSRRL 651
             F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++DRK +IEAAIVRIMKSR+ 
Sbjct: 655 HVFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKK 714

Query: 652 LDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDDNDRKMYRYLA 703
           + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R   DRK+Y Y+A
Sbjct: 715 MQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766


>UniRef100_Q13618-3 Splice isoform 3 of Q13618 [Homo sapiens]
          Length = 702

 Score =  662 bits (1707), Expect = 0.0
 Identities = 354/670 (52%), Positives = 475/670 (70%), Gaps = 32/670 (4%)

Query: 65  SFLEELNRKWNDHNKALQMIRDILMYMDRTFIPSAKKTPVHELGLNLWRESVIYSNQIRT 124
           +FL+ LN+ WNDH  A+ MIRDILMYMDR ++       V+ LGL ++R+ V+    IR 
Sbjct: 34  NFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRD 93

Query: 125 RLLNTLLELVQSERTGEVIDRGIMRNITKMLMDLG---PAVYGQDFEAHFLQVSAEFYQV 181
            L  TLL+++  ER GEV+DRG +RN  +MLM LG    +VY +DFEA FL++SAEF+Q+
Sbjct: 94  HLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQM 153

Query: 182 ESQRFIECCDCGDYLKKAERRLNEEMDRVGHYMDPETEKKINKVVETQMIENHMLRLIHM 241
           ESQ+F+       Y+KK E R+NEE++RV H +D  TE+ I KVVE ++I  HM  ++ M
Sbjct: 154 ESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEM 213

Query: 242 ENSGLVNMLCDDKYEDLGRMYNLFRRVADGLLKIREVMTLHIRESGKQLVTDPERLKDPV 301
           ENSGLV+ML + K EDLG MY LF RV +GL  + E M+ ++RE GK LV++    K+PV
Sbjct: 214 ENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPV 273

Query: 302 EFVQRLLDEKDKYDKIINQAFNNDKSFQNALNSSFEYFINLNPRSPEFISLFVDDKLRKG 361
           +++Q LLD K ++D+ + ++FNND+ F+  +   FEYF+NLN RSPE++SLF+DDKL+KG
Sbjct: 274 DYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKG 333

Query: 362 LKGVNEDDVEVTLDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLK 421
           +KG+ E +VE  LDK M+LFR++QEKDVFE+YYKQHLA+RLL+ K+VSDD+E+++I KLK
Sbjct: 334 VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLK 393

Query: 422 TECGYQFTSKLEGMFTDMKTSQDTMQGF----YASHPDLGDGPTLTVQVLTTGSWPTQSS 477
           TECG QFTSKLEGMF DM  S  TM  F     A+   LG G  LTV+VLTTG WPTQS+
Sbjct: 394 TECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLG-GVDLTVRVLTTGYWPTQSA 452

Query: 478 I-TCNLPVEISALCEKFRSYYLGTHTGRRLSWQTNMGFADLKATF------------GKG 524
              CN+P       E FR +YL  H+GR+L+ Q +MG ADL ATF            G G
Sbjct: 453 TPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVG 512

Query: 525 ---------QKHELNVSTYQMCVLMLFNNADKLSYKEIEQATEIPAPDLKRCLQSLALVK 575
                    +KH L VST+QM +LMLFNN +K +++EI+Q T+IP  +L R LQSLA  K
Sbjct: 513 GAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGK 572

Query: 576 -GRNVLRKEPMSKDVGEDDAFSVNDKFSSKLYKVKIGTVVA-QKESEPEKQETRQRVEED 633
             + VL KEP SK++     F+VND+F+SKL++VKI TV A Q ES+PE++ETRQ+V++D
Sbjct: 573 PTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDD 632

Query: 634 RKPQIEAAIVRIMKSRRLLDHNNLIAEVTKQLQLRFLANPTEVKKRIESLIERDFLERDD 693
           RK +IEAAIVRIMKSR+ + HN L+AEVT+QL+ RFL +P  +KKRIE LIER++L R  
Sbjct: 633 RKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTP 692

Query: 694 NDRKMYRYLA 703
            DRK+Y Y+A
Sbjct: 693 EDRKVYTYVA 702


  Database: uniref100
    Posted date:  Jan 5, 2005  1:24 AM
  Number of letters in database: 848,049,833
  Number of sequences in database:  2,790,947
  
Lambda     K      H
   0.320    0.136    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,130,148,319
Number of Sequences: 2790947
Number of extensions: 47044986
Number of successful extensions: 157100
Number of sequences better than 10.0: 489
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 155012
Number of HSP's gapped (non-prelim): 654
length of query: 703
length of database: 848,049,833
effective HSP length: 135
effective length of query: 568
effective length of database: 471,271,988
effective search space: 267682489184
effective search space used: 267682489184
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 78 (34.7 bits)