BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC145202.5 - phase: 0 /pseudo
         (1053 letters)

Database: uniref100 
           2,790,947 sequences; 848,049,833 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

UniRef100_O24308 DNA topoisomerase II [Pisum sativum]                 988  0.0
UniRef100_Q8GSC4 DNA topoisomerase II [Nicotiana tabacum]             857  0.0
UniRef100_Q6Z8D9 Putative DNA topoisomerase II [Oryza sativa]         839  0.0
UniRef100_P30182 DNA topoisomerase II [Arabidopsis thaliana]          825  0.0
UniRef100_UPI0000430198 UPI0000430198 UniRef100 entry                 677  0.0
UniRef100_Q6PUA3 DNA topoisomerase type 2 [Tetrahymena thermophila]   654  0.0
UniRef100_Q7RJ69 DNA topoisomerase II, putative [Plasmodium yoel...   653  0.0
UniRef100_UPI00003C1D48 UPI00003C1D48 UniRef100 entry                 645  0.0
UniRef100_Q8X1U1 DNA topoisomerase II [Penicillium marneffei]         637  0.0
UniRef100_Q8ILC8 DNA topoisomerase II, putative [Plasmodium falc...   632  e-179
UniRef100_Q7Z2D0 DNA topoisomerase [Plasmodium falciparum]            632  e-179
UniRef100_P41001 DNA topoisomerase II [Plasmodium falciparum]         630  e-179
UniRef100_Q6PUA4 DNA topoisomerase type 2 [Tetrahymena thermophila]   629  e-178
UniRef100_Q8X1U4 DNA topoisomerase II [Aspergillus niger]             627  e-178
UniRef100_UPI00003AC994 UPI00003AC994 UniRef100 entry                 624  e-177
UniRef100_Q8X1U6 DNA topoisomerase II [Aspergillus flavus]            624  e-177
UniRef100_Q9NEE4 DNA topoisomerase II [Leishmania major]              621  e-176
UniRef100_O55079 Topoisomerase II alpha [Homo sapiens]                621  e-176
UniRef100_P41515 DNA topoisomerase II, alpha isozyme [Cricetulus...   620  e-176
UniRef100_O42130 DNA topoisomerase II, alpha isozyme [Gallus gal...   620  e-176

>UniRef100_O24308 DNA topoisomerase II [Pisum sativum]
          Length = 1462

 Score =  988 bits (2553), Expect = 0.0
 Identities = 560/966 (57%), Positives = 674/966 (68%), Gaps = 72/966 (7%)

Query: 130  WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
            WT V FKPDL+KF M  LE+DV+ALMKKRVLDMA C G+TV V LNGT+I  KSF+DYA+
Sbjct: 203  WTKVTFKPDLEKFKMAYLEEDVVALMKKRVLDMAGCFGKTVKVELNGTLIRFKSFRDYAD 262

Query: 190  FFL---DRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQ 246
             FL   +++KP PLPR HAK+GDR EIC+SLSDG+FQQVSFVNSIATIKGGTHVDYIT Q
Sbjct: 263  LFLKCAEKSKPMPLPRIHAKVGDRWEICISLSDGQFQQVSFVNSIATIKGGTHVDYITNQ 322

Query: 247  ITTYIKKEV-LKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLKF- 304
            ITTYI  +V  KKK  NV A TVKN LWVFVN+LIDNPAF+SQTKE LTT+ A  G K  
Sbjct: 323  ITTYIMNKVNKKKKDANVKAHTVKNHLWVFVNSLIDNPAFDSQTKETLTTRQASFGSKCD 382

Query: 305  FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-----------------DAKLAGRPDSGKC 347
             P SML DV+KS I+D LL    FK    +                 DA  AG  +S KC
Sbjct: 383  VPESMLKDVEKSGIVDTLLSWADFKQSKDLKKTDGTKTQRLRGCKAEDANEAGGRNSEKC 442

Query: 348  TLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATR-DSRKLFKKKEIQNLMAIL 406
            TLILT+G   K LAM+GLS VV  D YGVFPL  KLLN     S+++   +EIQN+  IL
Sbjct: 443  TLILTEGDSAKALAMAGLS-VVGRDHYGVFPLRGKLLNVREASSKQIMDNEEIQNIKKIL 501

Query: 407  GLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFP 466
            GL +NK+Y+N K LRYG LM+MA+QD DG+H KGLLINF +SFWPSLLKV  F+  FT P
Sbjct: 502  GLQQNKEYTNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFTTP 561

Query: 467  IIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYF 524
            +I+ S  N + +      SF SM +YE WK+ LGN+A  W+IKY +GL  S+ QE REYF
Sbjct: 562  VIRASHPNKTIT------SFYSMPEYEAWKERLGNSATSWKIKYYKGLGTSTPQEGREYF 615

Query: 525  QDLGKHRAYFVWDDK-DETSIKLAFSKK-AEEWEAWIGNSQPGTC-NYERKVINYRNFVN 581
             DLG+HR  F+WDD+ D  +I+LAFSKK AE  + W+ N +PGTC ++E K+INY++FVN
Sbjct: 616  SDLGRHRKDFIWDDELDGNAIELAFSKKKAEGRKIWMRNFEPGTCRDHEAKLINYKDFVN 675

Query: 582  KELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYG 641
            KEL+  S                   R  LF SF+  L K+ +V +   YV+EHS  H+G
Sbjct: 676  KELILFS-------------------RADLFGSFKKKLYKEIKVAQFIGYVSEHSAYHHG 716

Query: 642  QQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPV 701
            +QS+ASTIIGMAQDFVGSNNINLL P GQFGT +LGGKDHAS+R +Y +L+ VTR LF  
Sbjct: 717  EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTCNLGGKDHASARYIYTELSPVTRCLFHE 776

Query: 702  DDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFL 761
             DDKLLEYLNEDG+SI+PNWY+PIIPLVLVNG   +GT +SS IP Y+P EII NVRR L
Sbjct: 777  HDDKLLEYLNEDGKSIEPNWYMPIIPLVLVNGSEGIGTGWSSYIPNYNPREIIANVRRLL 836

Query: 762  NNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKF 821
            N EE+V M PWYKGF GTIEKSAK  G Y V+G V  I+EQTFRI ELPIR WT+DYK+F
Sbjct: 837  NGEELVPMDPWYKGFRGTIEKSAKE-GGYIVNGTVTEIDEQTFRITELPIRKWTQDYKQF 895

Query: 822  LEKITARG------LIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTIST 875
            LE IT         LIE FRQ GD  IV+ ++ +K E+IATI   E L KKF LT TIST
Sbjct: 896  LESITDGAPNVKDPLIEDFRQNGDDAIVDIEIKMKPEKIATI-LQEGLFKKFKLTSTIST 954

Query: 876  SNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISN 935
            SNM+LFDAEG  KK++TPEQILEEF  LRL YY + K+Y++ N  +LL  L  K +FI  
Sbjct: 955  SNMHLFDAEGN-KKFDTPEQILEEFFPLRLDYYEKSKEYILGNLNRLLLILDNKVRFILG 1013

Query: 936  IVNEKFNPINR-RAELLIEIL--------KKGKSAEPHVAGAIDYSSKEQEAGEQESVSQ 986
            +VN +    NR +AELLIE+         +KGKS +P VAGA D  S+EQE  E E+ SQ
Sbjct: 1014 VVNGEIIVSNRKKAELLIELKEKGFTPMPRKGKSTKPQVAGANDDDSEEQEDAEPETASQ 1073

Query: 987  SVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLEL 1046
            SVS+EGAT GDY+ L SLP    TLES++KL  E  EKE E + L  T    +WL DL+ 
Sbjct: 1074 SVSVEGATWGDYDDLLSLPIGTLTLESVQKLLDEKTEKEKEYEILSGTPTTSLWLKDLDE 1133

Query: 1047 FEKEFD 1052
            FEK+ D
Sbjct: 1134 FEKKLD 1139


>UniRef100_Q8GSC4 DNA topoisomerase II [Nicotiana tabacum]
          Length = 1482

 Score =  857 bits (2215), Expect = 0.0
 Identities = 480/963 (49%), Positives = 636/963 (65%), Gaps = 54/963 (5%)

Query: 130  WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
            WT V  KPDL KF+M++LE+DV+ALM+KRV+D+  CLG+TV V LN   IPVKSF++Y  
Sbjct: 207  WTKVSSKPDLAKFNMEHLEEDVVALMRKRVIDLGGCLGKTVKVKLNEQRIPVKSFEEYCK 266

Query: 190  FFLDR--AKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQI 247
             FLD   AK   L  T A    R EIC+SLS+G+FQQVSFVNSIATIKGGTHVDY+  QI
Sbjct: 267  LFLDSTDAKREFLKVTDADGLLRWEICVSLSEGQFQQVSFVNSIATIKGGTHVDYVANQI 326

Query: 248  TTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLKF-F 305
              +I   V+KK K+ N+ A  VKN LW+FVNALIDNPAF+SQTKE LT + +  G K   
Sbjct: 327  ANHIMGAVIKKNKNANIKAHAVKNHLWMFVNALIDNPAFDSQTKETLTLRQSSFGSKCEL 386

Query: 306  PGSMLNDVQKS-QILDNLLPRIPFKHRTHV-----------------DAKLAGRPDSGKC 347
                L  V+K+  I++ LL    FK+   +                 DA  AG  +S KC
Sbjct: 387  QPDFLKKVEKNIGIVETLLSWADFKNSKDLKKTDGKKSEKVKVEKLEDANDAGGRNSEKC 446

Query: 348  TLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQNLMAIL 406
            TLILT+G   K LAM+G+S VV  D YGVFPL  KLLN    S K + + KEI+ +  IL
Sbjct: 447  TLILTEGDSAKALAMAGIS-VVGRDHYGVFPLRGKLLNVREASHKQVSENKEIEAIKKIL 505

Query: 407  GLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFP 466
            GL   K+Y + K LRYG LM+M +QD DG+H KGLLINF ++FWPSLLKV  F+  F  P
Sbjct: 506  GLQTGKEYDSVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITP 565

Query: 467  IIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYF 524
            I+K +       K GK LSF +M +YE W+K LG  ++ W IKY +GL  S+++E +EYF
Sbjct: 566  IVKAT------HKSGKILSFYTMPEYESWRKSLGANSSGWSIKYYKGLGTSTSKEGKEYF 619

Query: 525  QDLGKHRAYFVW-DDKDETSIKLAFSKKA-EEWEAWIGNSQPGT-CNYERKVINYRNFVN 581
            QDL KHR  F+W D++D  SI+LAFSKK  E  + W+   +PGT  + + K I+Y  FVN
Sbjct: 620  QDLQKHRKDFIWADNQDGESIELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVN 679

Query: 582  KELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYG 641
            KEL+  SM +LQRSIPS++DGL  GQRK LFC+F+ N  K+ +V + + YV+EHS  H+G
Sbjct: 680  KELILFSMADLQRSIPSMLDGLKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHG 739

Query: 642  QQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPV 701
            +QS++STIIGMAQD+VGSNN+NLL P GQFGTR++GGKDHASSR +Y +L+ + R LFP 
Sbjct: 740  EQSLSSTIIGMAQDYVGSNNVNLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPK 799

Query: 702  DDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFL 761
            +DD + +YLNEDG+ I+P WY+PI+P+VL+NG   +GT +SS +P Y+P +++ NVRR L
Sbjct: 800  EDDTIHDYLNEDGQYIEPTWYVPIVPMVLINGSEGIGTGWSSYVPNYNPRDLVANVRRLL 859

Query: 762  NNEEMVSMKPWYKGFGGTIEKSA--KGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYK 819
            N+E M  M PWYKGF GTIEK+A  +    YTV G++E +NE T RI ELP+R WTEDYK
Sbjct: 860  NDEPMEPMDPWYKGFKGTIEKTATKEAGATYTVTGIIEEVNETTLRISELPVRRWTEDYK 919

Query: 820  KFLEKITARG------LIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTI 873
            +FLE +T          I+  R  GD   V F+V +  EE   + + E L KKF L  TI
Sbjct: 920  QFLESMTVSNDKAKDPFIKEVRAYGDENSVCFEV-IMSEENLILAQQEGLLKKFKLATTI 978

Query: 874  STSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFI 933
            STSNM+LFD+ GKIKKY+ PE ILEEF  +RL+YY +RK+ L++     L  +  K KFI
Sbjct: 979  STSNMHLFDSNGKIKKYDNPEDILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFI 1038

Query: 934  SNIVNEKFNPINR-RAELLIEILKKGKSAEPH---VAGAIDYSSKEQEAGEQESVSQSVS 989
              +V  +    NR RA+LL+E+ +KG +  P    V   +  +S + E  E+E       
Sbjct: 1039 LGVVKVEIIVNNRKRADLLLELKEKGFTPFPKKKAVEAVVADTSDDAEDSEEE------L 1092

Query: 990  IEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEK 1049
              G   GDY+YL S+P    TLE +++L AE D+   E++ + + +P L+WL DL++ EK
Sbjct: 1093 NRGVRAGDYDYLLSMPIGTLTLEKVQELCAERDQLNGEVEDMRNATPKLLWLKDLDVLEK 1152

Query: 1050 EFD 1052
            + D
Sbjct: 1153 QLD 1155


>UniRef100_Q6Z8D9 Putative DNA topoisomerase II [Oryza sativa]
          Length = 1525

 Score =  839 bits (2167), Expect = 0.0
 Identities = 482/1002 (48%), Positives = 633/1002 (63%), Gaps = 86/1002 (8%)

Query: 122  VSLCDNGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIP 180
            ++ C  G+ WT V FKPDL KF+M +LE DV+ALM+KRV+DMA  LG+TV V L+   +P
Sbjct: 203  ITKCKQGENWTRVTFKPDLAKFNMTHLENDVVALMRKRVVDMAGTLGKTVKVELDHQKVP 262

Query: 181  VKSFKDYANFFL-----DRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIK 235
            V SF DY   ++     DR     LP    K+ DR E+C+SLS+G+FQQVSFVN IATIK
Sbjct: 263  VHSFSDYVKLYIKSASKDRDDVNELPSISQKVNDRWEVCVSLSEGQFQQVSFVNRIATIK 322

Query: 236  GGTHVDYITKQITTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLT 294
            GGTHVDY+T QI T++   V K+ K+ ++ A  VK+ LWVFVNALIDNPAF+SQTKE LT
Sbjct: 323  GGTHVDYVTNQIATHVMNIVNKRNKNAHMKAHNVKSHLWVFVNALIDNPAFDSQTKETLT 382

Query: 295  TKPARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV------------------D 335
            T+ A  G K       L  V  S I+ NLL    FK    +                  D
Sbjct: 383  TRQASFGSKCELSDDFLKKVGSSAIVLNLLSWAEFKLSKELQKTDGSKRSRLTGIPKLED 442

Query: 336  AKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LF 394
            A  AG  DS  CTLILT+G   K LAM+G+S VV  D YGVFPL  KLLN    S K + 
Sbjct: 443  ANGAGGKDSNNCTLILTEGDSAKALAMAGIS-VVGRDYYGVFPLRGKLLNVREASHKQIM 501

Query: 395  KKKEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLL 454
            +  EIQN+  ILGL   K+Y + K LRYG LM+M +QD DG+H KGLLINF +SFWPSL+
Sbjct: 502  ENAEIQNIKQILGLQHGKQYDSTKGLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLI 561

Query: 455  KVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
            K+  F+  F  PIIK +  N  D K    L F SM +YE WK+ LG  A+ W IKY +GL
Sbjct: 562  KIPSFLVEFITPIIKAT--NKRDKKI--VLPFYSMPEYEQWKESLGGNASGWSIKYYKGL 617

Query: 515  --SSAQEVREYFQDLGKHRAYFVW-DDKDETSIKLAFSKKA-EEWEAWIGNSQPGT-CNY 569
              S++ E R+YFQD+ KH+  FVW +D+D+  I+LAFSKK   + + W+ N Q GT  + 
Sbjct: 618  GTSTSSEGRQYFQDIAKHKKDFVWKNDQDDNDIELAFSKKRITDRKEWLTNFQSGTHLDT 677

Query: 570  ERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLT 629
            E K I Y +F+NKEL+  SM +L RSIPS+VDGL  GQRK LFCSF+ NL K+ +V + +
Sbjct: 678  EGKYIKYSDFINKELIQFSMADLLRSIPSMVDGLKPGQRKILFCSFKRNLVKEIKVAQFS 737

Query: 630  AYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYI 689
             YV+EHS  H+G+QS+ASTI GMAQDFVGSNNINLL P GQFGTRD GGKD AS+R ++ 
Sbjct: 738  GYVSEHSAYHHGEQSLASTITGMAQDFVGSNNINLLQPNGQFGTRDQGGKDAASARYIFT 797

Query: 690  KLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYH 749
             L+ +TR +FP DDD LL YL+EDG+SI+P WY+PI+P+VLVNG   +GT +S+ IP Y+
Sbjct: 798  LLSPITRSIFPKDDDILLNYLDEDGQSIEPTWYVPILPMVLVNGSEGIGTGWSTFIPNYN 857

Query: 750  PYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIG--YYTVDGLVERINEQTFRIK 807
            P +I+ N+RR LN+E +  M PWY+GF G+I+K+    G   YTV G++E +++ T RI 
Sbjct: 858  PRDIVANLRRLLNDEPVEPMDPWYRGFKGSIQKTGTKAGGVSYTVTGIIEVVDDTTLRIT 917

Query: 808  ELPIRMWTEDYKKFL------------EKITARG----------------LIESFRQKGD 839
            ELPIR W++DYK+FL            +K   +G                 IE+F    D
Sbjct: 918  ELPIRRWSQDYKEFLISIGGTDKSKDKDKDKGKGKGKVKEKEKKEKDIEPFIEAFDTYSD 977

Query: 840  YEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEE 899
             + V F + + +E +A I   E L KKF LT TI T+NM+LFD+ GKI+KY+TPE IL+E
Sbjct: 978  DKNVEFLITLSKENMA-IALQEGLEKKFKLTTTIGTTNMHLFDSNGKIRKYDTPEDILKE 1036

Query: 900  FCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKG 958
            F  LRL++Y +RK+ L++N    L+ L  K +FI  +V       NR RAEL +E+ +KG
Sbjct: 1037 FFGLRLEFYEKRKRVLLENIELELKKLSNKVRFILAVVEGDIIVNNRKRAELFVELKQKG 1096

Query: 959  --------KSAEPHVAGAIDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFT 1010
                    + A P   GAI+   + +E+ E  +V  S         DYEYL S+     T
Sbjct: 1097 FDPFPRKKQRAGPSAVGAIEEDEENEESPEAANVGSS---------DYEYLLSMAIGTLT 1147

Query: 1011 LESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
            LE +++L AE    ENE+  L+ T P  +W+ DL+ FEKE D
Sbjct: 1148 LERVQQLIAEKGRMENEVAELKRTRPKSLWMRDLDAFEKELD 1189


>UniRef100_P30182 DNA topoisomerase II [Arabidopsis thaliana]
          Length = 1473

 Score =  825 bits (2132), Expect = 0.0
 Identities = 475/977 (48%), Positives = 626/977 (63%), Gaps = 57/977 (5%)

Query: 122  VSLCDNGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIP 180
            ++ C+  + WT V FKPDL KF+M  LE DV+ALM KRV D+A CLG++V V LNG  IP
Sbjct: 206  ITKCNKSENWTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIP 265

Query: 181  VKSFKDYANFFLDRAKPF----PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKG 236
            VKSF DY + +L  A       PLPR   K+ DR E+C+SLS+G+FQQVSFVNSIATIKG
Sbjct: 266  VKSFTDYVDLYLSAANKSRTEDPLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKG 325

Query: 237  GTHVDYITKQITTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTT 295
            GTHVDY+T QIT +I   V KK K+ NV A  VKN LWVFVNALIDNPAF+SQTKE LT 
Sbjct: 326  GTHVDYVTSQITNHIVAAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTL 385

Query: 296  KPARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-----------------DAK 337
            + +  G K       L  V KS +++NLL    FK    +                 DA 
Sbjct: 386  RQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVLVEKLDDAA 445

Query: 338  LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR-KLFKK 396
             AG  +S  CTLILT+G   K LA++G S V+  +  GVFPL  KLLN    S  ++   
Sbjct: 446  EAGGKNSRLCTLILTEGDSAKSLALAGRS-VLGNNYCGVFPLRGKLLNVREASTTQITNN 504

Query: 397  KEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKV 456
            KEI+NL  ILGL +N KY N   LRYGQ+M+M +QD DG+H KGLLINF +SFWPSLL+V
Sbjct: 505  KEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQV 564

Query: 457  SKFMSVFTFPIIKVSMYNASDSKKG--KELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
              F+  F  PI+K +       +KG  K LSF SM +YE+WK+ L   A  W+IKY +GL
Sbjct: 565  PSFLVEFITPIVKAT-------RKGTKKVLSFYSMPEYEEWKESLKGNATGWDIKYYKGL 617

Query: 515  --SSAQEVREYFQDLGKHRAYFVWDDK-DETSIKLAFSKKA-EEWEAWIGNSQPGTCNYE 570
              S+A+E +EYF +LG H+  FVW+D+ D  +I+LAFSKK  E  + W+ +  PG    +
Sbjct: 618  GTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSSYVPGNHLDQ 677

Query: 571  RKV-INYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLT 629
            R+  + Y +FVNKEL+  SM +LQRSIPS+VDGL  GQRK LF +F+    K+ +V +L 
Sbjct: 678  RQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLV 737

Query: 630  AYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYI 689
             YV+  S  H+G+QS+AS IIGMAQD+VGSNNINLL+P GQFGTR  GGKD AS+R ++ 
Sbjct: 738  GYVSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFT 797

Query: 690  KLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYH 749
            KL+ VTR+LFP DDD LL+YLNEDG+ I+P WY+PIIP VLVNG   +GT +S+ IP Y+
Sbjct: 798  KLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYN 857

Query: 750  PYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIG--YYTVDGLVERINEQTFRIK 807
            P EI+ NVRR LN E MV M PWY+GF GTIEK+A   G   YT+ GL E ++E T RI 
Sbjct: 858  PREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKEGGCTYTITGLYEEVDETTIRIT 917

Query: 808  ELPIRMWTEDYKKFLEKI-TARG--LIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELR 864
            ELPIR W +DYK FL+ + T  G    +  +   D + V+F + +  EE     + E   
Sbjct: 918  ELPIRRWNDDYKNFLQSLKTDNGAPFFQDVKAYNDEKSVDFDL-ILSEENMLAARQEGFL 976

Query: 865  KKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLR 924
            KKF LT TI+TSNM+LFD +G IKKY TPEQILEEF  LR +YY +RK+ +VKN    L 
Sbjct: 977  KKFKLTTTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELL 1036

Query: 925  SLRIKQKFISNIVNEKFNPINRRAELLIEIL---------KKGKSAEPHVAGAIDYSSKE 975
             L  K +FI  +++ +     R+   ++E L         +K +S E  +AGA+D  + E
Sbjct: 1037 KLENKARFILAVLSGEIIVNKRKKADIVEDLRQKGFTPFPRKAESVEAAIAGAVDDDAAE 1096

Query: 976  QEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTS 1035
            +   E+  V    S       +Y+YL ++   + T+E +++L A+ D+    +  ++ T+
Sbjct: 1097 EP--EEILVDPESSSSYIPGSEYDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTT 1154

Query: 1036 PDLMWLNDLELFEKEFD 1052
            P  +WL+DLE  +KE +
Sbjct: 1155 PKSLWLSDLESLDKELE 1171


>UniRef100_UPI0000430198 UPI0000430198 UniRef100 entry
          Length = 1272

 Score =  677 bits (1748), Expect = 0.0
 Identities = 405/978 (41%), Positives = 575/978 (58%), Gaps = 70/978 (7%)

Query: 124  LCDNGK---WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIP 180
            + DN K   WT + FKPDL++F M  ++ D  AL+ KRV DMA  + + V V LN   I 
Sbjct: 285  ITDNKKGEEWTKITFKPDLERFGMNGIDDDTNALLMKRVYDMAGTVKD-VKVFLNDERIK 343

Query: 181  VKSFKDYANFFLDRA--------------KPFPLPRTHAKLGDRLEICLSLSDGKFQQVS 226
            VK+FK Y   +L+ +              KP   P  +     R E+  +LSDG+F+QVS
Sbjct: 344  VKNFKQYVEMYLNASTTATSEAAGGAAVTKP---PIIYEVANKRWEVAFALSDGEFKQVS 400

Query: 227  FVNSIATIKGGTHVDYITKQITTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAF 285
            F NSIAT KGGTHVD I  Q+   +  ++ KK K   V    +KN +W+FVNALI+NPAF
Sbjct: 401  FTNSIATTKGGTHVDMIATQLANKLMDQIKKKNKAAPVKPFQIKNHMWIFVNALIENPAF 460

Query: 286  NSQTKEMLTTKPARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKH-----------RTH 333
            +SQTKE LT K +  G K       +  V K+ I+DN+L    FK            R+ 
Sbjct: 461  DSQTKENLTLKSSAFGSKCELSEEFIKKVAKTGIIDNVLNWARFKQDQILKKTDGTKRSR 520

Query: 334  V-------DAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNA 386
            +       DA  AG  +S  CTLILT+G   K LA+SGL AVV  D YGVFPL  KLLN 
Sbjct: 521  ISGIVKLEDANNAGGRNSKNCTLILTEGDSAKALAVSGL-AVVGRDEYGVFPLRGKLLNV 579

Query: 387  TRDSR-KLFKKKEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINF 445
                  ++ K  EIQ++  ILGL  N+ Y+ A  LRYG LM+M +QD DG+H KGL+INF
Sbjct: 580  REAGHDQIVKNVEIQHIKQILGLKHNQDYATADSLRYGHLMIMTDQDHDGSHIKGLIINF 639

Query: 446  FYSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTAND 505
               F+PSLL++  F+  F  PI+KV        K  KE+SF +M QYE+WK +  N    
Sbjct: 640  LDHFYPSLLRIPNFLVEFITPIVKVW-------KGKKEISFYTMPQYEEWKAQ-NNNGRG 691

Query: 506  WEIKYCQGL--SSAQEVREYFQDLGKHR-AYFVWDDKDETSIKLAFSKK-AEEWEAWIGN 561
            WE KY +GL  S++ + ++YF DL KHR A+     +D   I +AF+KK A++ + W+  
Sbjct: 692  WESKYYKGLGTSTSADAKKYFSDLDKHRLAFETMQPEDRQLIDMAFNKKKADDRKEWLRQ 751

Query: 562  SQPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLT 620
             +PGT  +++ + +   +FVNKEL+  SM +  RSIPSV DGL  GQRK LF  F+ NLT
Sbjct: 752  FKPGTYLDHDVQSLPISDFVNKELILFSMADNIRSIPSVADGLKPGQRKVLFGCFKRNLT 811

Query: 621  KQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKD 680
            K+ +V +L  YV+E +  H+G+ S+ STI+G+AQ+FVGSNNINLL P GQFGTR  GGKD
Sbjct: 812  KEIKVAQLAGYVSEKTAYHHGEASLTSTIVGLAQNFVGSNNINLLDPNGQFGTRLAGGKD 871

Query: 681  HASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTC 740
             AS+R ++  L  +TR +F   DD LL YL EDG SI+P++++P +P+VL+NG   +GT 
Sbjct: 872  AASARYIFTNLPRMTRAIFHPADDGLLNYLVEDGMSIEPDYFMPTVPMVLINGADGIGTG 931

Query: 741  FSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERIN 800
            +S+ IP Y+P +I++N+RR +  EE   M PW++GF G IE+  +    Y V G++E+IN
Sbjct: 932  WSTAIPNYNPVDIVENLRRMMRGEEPEKMTPWFRGFKGFIERIDQ--DKYKVSGIIEKIN 989

Query: 801  EQTFRIKELPIRMWTEDYKKFLEKIT-----ARGLIESFRQKGDYEIVNFKVNVKQEEIA 855
            + T  I ELPIR WT+D+K+ LE++T         I+ + +      V+F+V++ ++ +A
Sbjct: 990  DTTLEITELPIRRWTQDFKEMLEEMTTGTDKVPQTIKDYEEHHTDTTVHFRVHMTEKNLA 1049

Query: 856  TIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYL 915
              EK E   K+F LT ++ T NM  FD  GKIKKY +PE+ILEEF   RL++Y  RKQ+L
Sbjct: 1050 DAEK-EGFDKRFKLTTSLGTGNMVCFDLNGKIKKYASPEEILEEFFHKRLEFYGHRKQHL 1108

Query: 916  VKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEILKKGKSAEPHVAGAIDYSSKE 975
                 +    L  + +F+  I+ ++     +R   ++  L+  K              + 
Sbjct: 1109 ADELNRQFERLSNQARFVHMIITKELVVSGKRRPDIVAELRSLKFK------PFPKKERA 1162

Query: 976  QEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTS 1035
            +E GE E+  +    +     DY+YL  +   + T E ++KL AE D KE EL  L   S
Sbjct: 1163 KEEGENEAAEEEEDGDEGQASDYDYLLGMAIWSLTSEKVEKLLAERDAKEQELIELLKLS 1222

Query: 1036 PDLMWLNDLELFEKEFDV 1053
            P+ +W  DL+ F  E+ +
Sbjct: 1223 PNNIWDRDLDNFLAEWQL 1240


>UniRef100_Q6PUA3 DNA topoisomerase type 2 [Tetrahymena thermophila]
          Length = 1662

 Score =  654 bits (1688), Expect = 0.0
 Identities = 391/972 (40%), Positives = 571/972 (58%), Gaps = 65/972 (6%)

Query: 122  VSLCDNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPV 181
            +S      +T + F PDL KF MK LEKD++ LMKKRV DMA  +G +V V LNG  I +
Sbjct: 180  ISSYTESDYTKITFYPDLKKFHMKELEKDIVDLMKKRVYDMAGVIGGSVKVSLNGERISI 239

Query: 182  KSFKDYANFFLDR--AKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTH 239
             SF DY +F+L    A+   +         R E+  SLS+G+FQQVSFVNSI T KGGTH
Sbjct: 240  SSFSDYCDFYLKNQGAEVIKVSDNKGTNNQRWEVIASLSEGQFQQVSFVNSICTSKGGTH 299

Query: 240  VDYITKQITTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPA 298
            V+YIT QIT  + + + KK K +N+    VK+ LW+FVN LI+NP+F++QTKE LT +  
Sbjct: 300  VNYITDQITEKLMETLKKKEKSLNIKQFQVKSHLWIFVNCLIENPSFDTQTKETLTLRQQ 359

Query: 299  RLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKL 338
              G         + ++ KS I++++L +   K +  +                   DA  
Sbjct: 360  SFGSTCEVSEKFIKELLKSNIINHILLQARAKEQAKMAKTLSAKKQSRLLGVPKLEDAND 419

Query: 339  AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDS--RKLFKK 396
            AG  ++  CTLI+T+G   K LAMSG+  VV  D +GVFPL  K+LN  RDS  +++ + 
Sbjct: 420  AGTRNAESCTLIITEGDSAKALAMSGIE-VVGRDKFGVFPLKGKMLNV-RDSTSKQITEN 477

Query: 397  KEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKV 456
             EIQN++ ++G+  N  Y N K LRYG +M+MA+QD DG+H KGL INF  +FWPSL ++
Sbjct: 478  LEIQNIIKVMGMKLNTNYDNVKSLRYGSIMIMADQDHDGSHIKGLFINFIQNFWPSLFQM 537

Query: 457  SKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL-- 514
              F+  F  PI+KV   N S       +SF S+Q ++ WK    N  + W+IKY +GL  
Sbjct: 538  DGFLKEFITPIVKVRKGNQS-------ISFFSIQDFKRWKSTCPNQ-HLWKIKYYKGLGT 589

Query: 515  SSAQEVREYFQDLGKHRAYFVWDDKD-ETSIKLAFSKK-AEEWEAWIGNSQPG-TCNYER 571
            S+ QE +EYF ++ KH   F ++ KD E +I LAF+KK AE+ + W+    P    ++ +
Sbjct: 590  STDQEAQEYFGNINKHVISFKYNGKDDEDAIDLAFNKKRAEDRKKWLVKYDPEENVDHSQ 649

Query: 572  KVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAY 631
            K + Y++FVNKEL+  S  +  RSIPS+ DGL  GQRK LF  F+ NL  + +V +L+ Y
Sbjct: 650  KHLTYKDFVNKELINFSNSDNARSIPSLCDGLKPGQRKILFACFKRNLKNEIKVAQLSGY 709

Query: 632  VTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKL 691
            V EHS  H+G+QS+ STI+GMAQ FVG+NNIN L+P GQFG+R++GGK+ AS+R ++  L
Sbjct: 710  VAEHSAYHHGEQSLESTIVGMAQSFVGTNNINYLMPIGQFGSRNMGGKEAASARYIHTCL 769

Query: 692  NCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPY 751
            N +TR +FP  DD +L YL ++G+ ++P +Y+PIIP  L+NG   +GT +S+ IP Y+P 
Sbjct: 770  NKITRCVFPEPDDHILYYLEDEGQQVEPIYYLPIIPTALLNGADGIGTGWSTSIPCYNPR 829

Query: 752  EIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPI 811
            E++ ++ + +       + PWYKGF G I  + K     TV G    +NE T  I ELPI
Sbjct: 830  ELVDSIEKRMMGVPFTDLLPWYKGFTGEISNNEK--SQITVSGKYHLVNETTIEITELPI 887

Query: 812  RMWTEDYKKFLEKITARGLIESFRQKGDYEI-----------VNFKVNVKQEEIATIEKD 860
            + W  DYK FLE+      +ES + K D EI           V+F V + ++++  +++ 
Sbjct: 888  KKWIRDYKNFLEE-----KLESTKDK-DPEIEDIKEYHAGNRVHFVVKMSEKQMEKVQR- 940

Query: 861  EELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFT 920
            E + K F L  TI T+NM LF+ EGK+ +Y    +I+EEF  +RL  Y RRK+YLV    
Sbjct: 941  EGIDKYFKLQSTIPTTNMVLFNHEGKLTRYANICEIMEEFYEVRLNAYKRRKEYLVSKIE 1000

Query: 921  QLLRSLRIKQKFISNIVNEKFNPIN-RRAELLIEILKKG---KSAEPHVAGAIDYSSKEQ 976
            + L  L  K++FI  ++NE     N +R +L+ E+  +G       P +  +   S  EQ
Sbjct: 1001 RDLEILSNKKRFILAVINESIRVRNAKRKDLIKELSVQGYVQMKDMPKIKSSKLTSQLEQ 1060

Query: 977  EAGEQESVSQ-SVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTS 1035
            E  +  +      +       +Y YL SLP  + T E +++++ E   K++EL  L  T 
Sbjct: 1061 EQNQDSNEENFETNPNEINAKEYNYLLSLPMWSLTYEKVEEIKQEQKNKQDELDKLVATE 1120

Query: 1036 PDLMWLNDLELF 1047
               +W  DL+ F
Sbjct: 1121 VIDIWKEDLKNF 1132


>UniRef100_Q7RJ69 DNA topoisomerase II, putative [Plasmodium yoelii yoelii]
          Length = 1489

 Score =  653 bits (1684), Expect = 0.0
 Identities = 405/1033 (39%), Positives = 586/1033 (56%), Gaps = 128/1033 (12%)

Query: 127  NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
            NGK +  V FKPDLDKF M  L+ D+  L+ KRV D+A  C    V V LNGT +PVK F
Sbjct: 193  NGKDYVKVTFKPDLDKFGMSELDDDIECLLHKRVYDLAGTC---NVRVYLNGTRLPVKDF 249

Query: 185  KDYANFFL-DRAKPFPLP---------RTHAKLG---DRLEICLSLSDG----------- 220
            K Y + +L D   P   P          T A +    D L++ +S  +G           
Sbjct: 250  KSYVDLYLRDNNTPNTNPSVSKNALNGNTDASVNKTIDNLDVSISHENGGGAGDITPTKT 309

Query: 221  --------------------------------------KFQQVSFVNSIATIKGGTHVDY 242
                                                  +FQQVSFVNSI T KGGTHV Y
Sbjct: 310  TEENGNSNFNNNKYEEEIVKIHEKQHRWEIVISKTDGSQFQQVSFVNSICTTKGGTHVSY 369

Query: 243  ITKQITTYIKKEVLKKKH--VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARL 300
            I  Q+   + K+   K    + + A  ++N LWVFVN LI NP F+SQTKE LTTK A+ 
Sbjct: 370  IVDQLLNSLSKKANAKNKGGMEIKAGHIRNHLWVFVNCLIVNPTFDSQTKETLTTKQAKF 429

Query: 301  GLK-FFPGSMLNDVQKSQILDNLLPRIPFKHRTHV----------------------DAK 337
            G K       +N+V KS IL N+L     K +  +                      DA 
Sbjct: 430  GSKCTLTDKTINNVLKSSILSNILLWAQAKAQVELRKKMKAGSSKARERIIGIPKLEDAN 489

Query: 338  LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDS--RKLFK 395
             AG   S +CTLILT+G   K   ++GLS +V  D YGVFPL  KLLN  RD+  ++L  
Sbjct: 490  DAGSKYSQECTLILTEGDSAKTSCLAGLS-IVGRDRYGVFPLKGKLLN-VRDASFKQLMD 547

Query: 396  KKEIQNLMAILGL-VRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLL 454
             KEIQN+  I+GL + +K   + K LRYG LM+M +QD DG+H KGLLIN  + FWPSLL
Sbjct: 548  NKEIQNIFKIMGLDITDKNKQDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLL 607

Query: 455  KVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
            K   F+  F  PI+KV        K  +ELSF ++ +YE WK+        W+IKY +GL
Sbjct: 608  KHKGFLCEFVTPIVKV-------QKGNQELSFFTIAEYEQWKENTNLVG--WKIKYYKGL 658

Query: 515  --SSAQEVREYFQDLGKHRAYFVW-DDKDETSIKLAFSKK-AEEWEAWIGNSQPGT-CNY 569
              S+ +E ++YF D+  H+ +F+W  D+D  SI +AFSKK  E+ + W+ N   G+  ++
Sbjct: 659  GTSTDKEFKQYFSDIQSHKIFFLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDH 718

Query: 570  ERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLT 629
            + K ++Y +FVNKEL++ S  + +RSIP+++DG   GQRK L+  F+ NL  + +V +L 
Sbjct: 719  KEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGWKPGQRKVLYGCFKRNLKNECKVAQLV 778

Query: 630  AYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYI 689
             Y+ EHS  H+G+ S+  TII MAQ FVGSNNIN L P GQFG+R  GGKD +++R ++ 
Sbjct: 779  GYIAEHSAYHHGESSLQQTIINMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFT 838

Query: 690  KLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYH 749
            KL   TR +F   DD +L+YLNE+G+ I+P +YIP+IP +LVNGC  +GT +SS IP Y+
Sbjct: 839  KLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYN 898

Query: 750  PYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKEL 809
              +II N++++++ E +V M PWYK F G IE + K  GY T+ G++ +I+++T  I EL
Sbjct: 899  YKDIINNIKKYIDKEPLVPMVPWYKDFKGRIEPNGKS-GYETI-GIINKIDDETLEITEL 956

Query: 810  PIRMWTEDYKKFLEKITA---RGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKK 866
            PI+ WT+DYK+FLE++       LI  +     +E V F + +   ++   E +E L K 
Sbjct: 957  PIKRWTQDYKEFLEELLTDEKNQLIIDYIDNSSHEDVCFTIKMDPIKLKRAE-EEGLEKV 1015

Query: 867  FNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSL 926
            F L  T++T+NM LFD + K+++Y +   IL++FC  RL  Y  RK YL+    +  R +
Sbjct: 1016 FKLKSTLTTTNMTLFDPKLKLQRYASELDILKDFCFHRLNAYTDRKNYLISKLEKEKRII 1075

Query: 927  RIKQKFISNIVNEKFNPINRRAELLIEILKKGKSAEPHVAGAIDYSSKEQEAGEQESVSQ 986
              K KFI  I+N +     ++ ++L+E L + K  +P+      +  K++E  EQE +  
Sbjct: 1076 SNKTKFILAIINGELVVNKKKKKILVEELYR-KGYDPY---KDIHKLKKEEIFEQELLDA 1131

Query: 987  SVS-------IEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLM 1039
            + +       I G T+ DY YL ++P  + TLE +++L ++L EKE EL+ L+  + + M
Sbjct: 1132 AENPEDNEEIIAGVTVKDYNYLLNMPIFSLTLEKVEELLSQLKEKEQELEILKSITVETM 1191

Query: 1040 WLNDLELFEKEFD 1052
            WL D+E  E+  +
Sbjct: 1192 WLKDIEKVEEAIE 1204


>UniRef100_UPI00003C1D48 UPI00003C1D48 UniRef100 entry
          Length = 1518

 Score =  645 bits (1664), Expect = 0.0
 Identities = 389/980 (39%), Positives = 564/980 (56%), Gaps = 83/980 (8%)

Query: 127  NGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKD 186
            N ++T++ FKPDL  F M  ++  + ALM KRV DMA  + + + V LNG ++ +K+FK 
Sbjct: 279  NDEYTSITFKPDLALFGMDAIDDHMEALMLKRVYDMAGTV-KGIKVTLNGELLKIKNFKQ 337

Query: 187  YANFFLDRA-----------------------KPFPLPRTHAKLGDRLEICLSLSDGKFQ 223
            Y   ++                          KP  +  +    G   E+  ++SDG+F+
Sbjct: 338  YVEMYVSAINELGGKADNGEEDAAGLPTSAAPKPAIIYESTVDKGRNWEVAFAVSDGEFR 397

Query: 224  QVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKKKHVN-VNADTVKNQLWVFVNALIDN 282
            QVSFVN+IATIKGG HVD++  Q+ + + + V K KH   V  + V+ QLWVFVN  I N
Sbjct: 398  QVSFVNNIATIKGGKHVDHVADQVISRLIEHVKKDKHTGKVMPNQVRQQLWVFVNCQIVN 457

Query: 283  PAFNSQTKEMLTTKPARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKH----------- 330
            P F+ QTKE LT K +  G K+         V KS ++DN++    FK            
Sbjct: 458  PTFDGQTKETLTLKQSAFGSKWTLTDEFARKVIKSGVVDNIVSFARFKQDQALKKTDGHK 517

Query: 331  RTHV-------DAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKL 383
            RT +       DA  AG   +  CTLILT+G   K LA++G+   V  D YGVFPL  KL
Sbjct: 518  RTRITNIPKLEDANNAGGRKAKDCTLILTEGDSAKSLAVAGI-VEVGRDNYGVFPLRGKL 576

Query: 384  LNATRDSR-KLFKKKEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLL 442
            LN    S  ++ K  EI+ +  ILGL   K+Y +   LRYG +M+M +QD DG+H KGL+
Sbjct: 577  LNVREASHDQIMKNAEIKAIKEILGLQHGKQYLDTNSLRYGSIMIMTDQDHDGSHIKGLI 636

Query: 443  INFFYSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKE-LSFDSMQQYEDWKKELGN 501
            INF   F+PSLLK+  F+  F  PI++         +KGK+ +SF ++ +YE W+ +  N
Sbjct: 637  INFLDHFYPSLLKIPGFLVEFITPIVRC--------RKGKQDISFFTIPEYETWR-DAHN 687

Query: 502  TANDWEIKYCQGL--SSAQEVREYFQDLGKHR-AYFVWDDKDETSIKLAFSKK-AEEWEA 557
                W IKY +GL  S +Q+ + YF+ L KH+ A+ V  D D   I LAF+KK A++ + 
Sbjct: 688  GGKGWHIKYYKGLGTSESQDAKRYFRALEKHKLAFDVTRDGDRELIDLAFNKKKADDRKE 747

Query: 558  WIGNSQPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFE 616
            W+   +PGT  ++    I Y +F+NKEL+  SM +  RSIPS +DGL  GQRK ++  F+
Sbjct: 748  WLRQFRPGTYLDHNTDRIPYADFINKELILFSMADNLRSIPSAIDGLKPGQRKVMYVMFD 807

Query: 617  MNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDL 676
                 + +V  L   V   +  H+G+ +++ TI+G+AQ+FVGSNN+NLL P GQFGTR L
Sbjct: 808  RKSNSELKVNTLVGNVLGQAAYHHGEAALSMTIVGLAQNFVGSNNVNLLEPRGQFGTRLL 867

Query: 677  GGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHA 736
            GGKD AS R ++  L  + R LFP  DD LL+YL +DG+ ++P+WYIP++P VL+NG   
Sbjct: 868  GGKDAASGRYIFTALPKIARALFPATDDALLDYLEDDGQKVEPHWYIPVVPQVLLNGAEG 927

Query: 737  MGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLV 796
            +GT +S+ +P Y+P+EI+ N+RR +  E++V MKPWY+GF G +E+   G G + + G V
Sbjct: 928  IGTGWSTSVPNYNPHEIVANLRRRMAGEDVVPMKPWYRGFNGDVEEF--GPGRFKISGRV 985

Query: 797  ERINEQTFRIKELPIRMWTEDYKKFLE-------KITARGLIESFRQKGDYEIVNFKVNV 849
             +I+E+T+ I ELPIR WT +YK+ LE       KI A   I+ +++      VNF V +
Sbjct: 986  TQIDEKTYEITELPIRTWTSNYKELLEERIVSSDKIPA--TIKDYKEYHTESTVNFIVEL 1043

Query: 850  KQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYV 909
              +  A I  D+ +   F L+C IST+NM LFD +GKIKKY + E+ILEEF  LRL YY 
Sbjct: 1044 TAKGQAEI-ADKGVEAFFKLSCQISTTNMVLFDQDGKIKKYTSAEEILEEFYLLRLSYYQ 1102

Query: 910  RRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVAGA 968
            +RK+YLV     +   L  + +F+  I++ +    NR RA+++ E+ +K     P    A
Sbjct: 1103 KRKEYLVDQLKLMYDKLSNQARFVQMIISRQLVVSNRKRADIVAELRQKDFRPFPKQGKA 1162

Query: 969  -IDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENE 1027
             I    ++ EA + E +S           D++YL ++   N T E + KL  E D KE E
Sbjct: 1163 SIAAEPEDDEAIDDEDISAD--------SDFDYLLNMAIYNLTKEKVDKLLKERDHKEEE 1214

Query: 1028 LKTLEHTSPDLMWLNDLELF 1047
            LK L   SP  +W  DL  F
Sbjct: 1215 LKILIGRSPQNLWDEDLTKF 1234


>UniRef100_Q8X1U1 DNA topoisomerase II [Penicillium marneffei]
          Length = 1162

 Score =  637 bits (1642), Expect = 0.0
 Identities = 387/966 (40%), Positives = 561/966 (58%), Gaps = 60/966 (6%)

Query: 130  WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
            +T V FKPD  KF M  ++ D  AL+K+RV D+A      V V LNG+ IPV++FK Y  
Sbjct: 203  YTKVTFKPDYQKFGMDGMDDDFEALVKRRVYDLAGTA--KVAVKLNGSRIPVRNFKKYME 260

Query: 190  FFLDRAKPFPLPRTHAKLGDRLEIC-----------LSLSDGKFQQVSFVNSIATIKGGT 238
             +    K     R    + D+ EI             ++SDG FQQVSFVNSIAT  GG+
Sbjct: 261  MY---TKAIKKERGEEAVNDKSEIVTASPDPRWEVGFAVSDGSFQQVSFVNSIATTSGGS 317

Query: 239  HVDYITKQITTYIKKEVLKKKH--VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTK 296
            HV+YI  QI   + + V KK      + A  ++N +++FVNALI NPAF SQTKE LTTK
Sbjct: 318  HVNYIADQICNRLAEAVKKKNKQGATLKASQIRNHIFIFVNALIVNPAFTSQTKEQLTTK 377

Query: 297  PARLGLK-FFPGSMLNDVQKSQILDNLLP-----------------RIPFKHRTHVDAKL 338
            P++ G K          V K++++ N+L                  R    +    DA  
Sbjct: 378  PSQFGSKCILDDDFYKKVLKTEVMTNILHFAEKKADQLLKKTDGGRRSRMNNPKLTDANK 437

Query: 339  AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR--KLFKK 396
            AG  D   CTLILT+G   K LAM+G  AVV PDL+GVFPL  KLLN  RD+   ++ K 
Sbjct: 438  AGTKDGHHCTLILTEGDSAKGLAMAG-RAVVGPDLFGVFPLRGKLLNV-RDASVDQISKN 495

Query: 397  KEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKV 456
             EIQN+ + +GL   K+Y++ + LRYG LM+M +QD DG+H KGLLINF    +PSLLK+
Sbjct: 496  AEIQNIKSFIGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKI 555

Query: 457  SKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL-- 514
             +F+  F  PIIKV   +  +  K K  SF +M +YE WK+E  N  + W+ KY +GL  
Sbjct: 556  PEFLIEFITPIIKVWKGDPKNPTKSK--SFFTMPEYEQWKEENKNDLS-WQHKYYKGLGT 612

Query: 515  SSAQEVREYFQDLGKH-RAYFVWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGT-CNYER 571
            S+ ++ + YF+DL +H + +    D +   I LAFSKK A+E + W+   +PGT  ++  
Sbjct: 613  STTEDAQIYFRDLDRHLKEFHTMQDHEAQLIDLAFSKKKADERKEWLRQYKPGTFLDHST 672

Query: 572  KVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAY 631
            K I Y +F+NKEL+  SM + QRSIPSVVDGL  GQRK L+  F+ NL K  +V  L  +
Sbjct: 673  KQITYTDFINKELILFSMADNQRSIPSVVDGLKPGQRKVLYTCFKRNLKKDMKVVELAGH 732

Query: 632  VTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKL 691
            V+  +   +G+ S+  TI+G+AQ FVGSNN+N L P G FG+R  GG D AS+R +Y +L
Sbjct: 733  VSGMTAYQHGETSLQQTIVGLAQTFVGSNNLNCLEPSGNFGSRLQGGADCASARYIYTRL 792

Query: 692  NCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPY 751
            +   R +F   D+ LL Y  +DG  I+P  Y+P++PL+L+NG   +GT +SS IP Y+P 
Sbjct: 793  SPFARRVFNQQDEPLLTYNEDDGEKIEPELYVPVVPLILINGADGIGTGWSSSIPNYNPE 852

Query: 752  EIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPI 811
            +I+ N++R ++ EE   M+PW++GF G  E + +G   Y   G +  +N++   I ELPI
Sbjct: 853  DIVANLKRMMDGEEPEPMQPWFRGFNG--EVTPQGPDRYKFSGRIHELNDKEVEITELPI 910

Query: 812  RMWTEDYKKFLEKI----TARGLIESFRQKGDYEIVNFKVNVKQEEI-ATIEKDEELRKK 866
            R WT+D+K  LE I         I+ ++    +  V+F + + ++ + A +E  E L +K
Sbjct: 911  RTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHLKAAVE--EGLEEK 968

Query: 867  FNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSL 926
            F L+ TI+T+N+  FD EG+I KY T   IL+EF  +RLKYY RRKQ+ +    + L   
Sbjct: 969  FKLSRTIATTNLVAFDPEGRITKYATVSDILKEFFAVRLKYYERRKQHQLSELQKQLDKF 1028

Query: 927  RIKQKFISNIVNEKF-NPINRRAELLIEILKKGKSAEPHVAGAIDYSSKEQEAGEQESVS 985
              + +FI  I++ K      ++A L+ E+ +KG    P VA A+     EQ   E+ES S
Sbjct: 1029 TNQARFIQMIIDGKLVVSKKKKATLITELKEKGFKPFPKVAEAVKAGETEQVVEEEES-S 1087

Query: 986  QSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLE 1045
            +  + E A+   Y+YL  +   + T E ++KL  ++ +KE E+  L   S + +W  DL+
Sbjct: 1088 EEANTEMAS-NAYDYLLGMAIWSLTQERVEKLLRQIGDKEVEIDELIKLSKEEIWRRDLD 1146

Query: 1046 LFEKEF 1051
             F  E+
Sbjct: 1147 DFINEW 1152


>UniRef100_Q8ILC8 DNA topoisomerase II, putative [Plasmodium falciparum]
          Length = 1472

 Score =  632 bits (1630), Expect = e-179
 Identities = 371/887 (41%), Positives = 536/887 (59%), Gaps = 62/887 (6%)

Query: 210  RLEICLSLSDG-KFQQVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKKKH--VNVNAD 266
            R EI +S SDG +FQQVSFVNSI T KGG+HV+YI +Q+ + + K+   K    + + + 
Sbjct: 330  RWEIVVSKSDGSQFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGGMEIKSG 389

Query: 267  TVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLK-FFPGSMLNDVQKSQILDNLLPR 325
             ++N LWVFVN LI NP F+SQTKE LTTKP + G K       +N+V KS IL N+L  
Sbjct: 390  HIRNHLWVFVNCLIVNPTFDSQTKETLTTKPVKFGSKCILSDKTINNVLKSPILSNILLW 449

Query: 326  IPFKHRTHV----------------------DAKLAGRPDSGKCTLILTQGQYVKDLAMS 363
               K +  +                      DA  AG   S +CTLILT+G   K   ++
Sbjct: 450  AQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLILTEGDSAKTSCLA 509

Query: 364  GLSAVVDPDLYGVFPLSSKLLNATRDS-RKLFKKKEIQNLMAILGL-VRNKKYSNAKCLR 421
            GLS +V  D YGVFPL  KLLN    S ++L   KEIQN+  I+GL + +K   + K LR
Sbjct: 510  GLS-IVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDITDKNKDDIKGLR 568

Query: 422  YGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKG 481
            YG LM+M +QD DG+H KGLLIN  + FWPSLLK   F+S F  PI+KV        K  
Sbjct: 569  YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQ-------KGS 621

Query: 482  KELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYFQDLGKHRAYFVWD-D 538
            +E SF ++ +YE WK+        W+IKY +GL  S+ +E ++YF D+  H+  F+W  D
Sbjct: 622  QEYSFFTIAEYEQWKENTNLLG--WKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGD 679

Query: 539  KDETSIKLAFSKKA-EEWEAWIGNSQPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSI 596
            +D  SI +AFSKK  E+ + W+ N   G+  +++ K ++Y +FVNKEL++ S  + +RSI
Sbjct: 680  RDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSI 739

Query: 597  PSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDF 656
            P+++DG   GQRK L+  F+ NL  + +V +L  Y+ EHS  H+G+ S+  TII MAQ F
Sbjct: 740  PNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTF 799

Query: 657  VGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRS 716
            VGSNNIN L P GQFG+R  GGKD +++R ++ KL   TR +F   DD +L+YLNE+G+ 
Sbjct: 800  VGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQK 859

Query: 717  IQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGF 776
            I+P +YIP+IP +LVNGC  +GT +SS IP Y+  +II N++R++N E ++ M PWYK F
Sbjct: 860  IEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDF 919

Query: 777  GGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITA---RGLIES 833
             G IE + K  GY T+ G++ +I+  T  I ELPI+ WT+DYK+FLE++       LI  
Sbjct: 920  KGRIESNGK-TGYETI-GIINKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLILD 977

Query: 834  FRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTP 893
            +     +E + F + +   ++   E +E L K F L  T++T+NM LFD   K+++Y+T 
Sbjct: 978  YIDNSSHEDICFTIKMDPAKLQKAE-EEGLEKVFKLKSTLTTTNMTLFDPNLKLQRYSTE 1036

Query: 894  EQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIE 953
              IL+EFC  RLK Y  RK YL+    +  R +  K KFI  IVN +     ++ ++L+E
Sbjct: 1037 LDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLVE 1096

Query: 954  ILKKGKSAEPHVAGAIDYSS-KEQEAGEQESVSQSVS-------IEGATLGDYEYLSSLP 1005
             L + K  +P+     D +  K++E  EQE +  + +       I G T+ DY+YL S+P
Sbjct: 1097 ELYR-KGYDPYK----DINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSMP 1151

Query: 1006 FENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
              + TLE ++ L  +L EKE EL+ L + + + MWL D+E  E+  +
Sbjct: 1152 IFSLTLEKVEDLLTQLKEKERELEILRNITVETMWLKDIEKVEEAIE 1198



 Score = 54.3 bits (129), Expect = 2e-05
 Identities = 31/68 (45%), Positives = 43/68 (62%), Gaps = 5/68 (7%)

Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
           NGK +  V FKPDL+KF M  ++ D+ +L+ KRV D+A  C   +V V LNG  + VK F
Sbjct: 193 NGKDYVKVTFKPDLNKFGMTEMDDDIESLLFKRVYDLAGTC---SVRVYLNGQRLAVKDF 249

Query: 185 KDYANFFL 192
           K Y + +L
Sbjct: 250 KSYVDLYL 257


>UniRef100_Q7Z2D0 DNA topoisomerase [Plasmodium falciparum]
          Length = 1397

 Score =  632 bits (1630), Expect = e-179
 Identities = 371/887 (41%), Positives = 536/887 (59%), Gaps = 62/887 (6%)

Query: 210  RLEICLSLSDG-KFQQVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKKKH--VNVNAD 266
            R EI +S SDG +FQQVSFVNSI T KGG+HV+YI +Q+ + + K+   K    + + + 
Sbjct: 330  RWEIVVSKSDGSQFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGGMEIKSG 389

Query: 267  TVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLK-FFPGSMLNDVQKSQILDNLLPR 325
             ++N LWVFVN LI NP F+SQTKE LTTKP + G K       +N+V KS IL N+L  
Sbjct: 390  HIRNHLWVFVNCLIVNPTFDSQTKETLTTKPVKFGSKCILSDKTINNVLKSPILSNILLW 449

Query: 326  IPFKHRTHV----------------------DAKLAGRPDSGKCTLILTQGQYVKDLAMS 363
               K +  +                      DA  AG   S +CTLILT+G   K   ++
Sbjct: 450  AQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLILTEGDSAKTSCLA 509

Query: 364  GLSAVVDPDLYGVFPLSSKLLNATRDS-RKLFKKKEIQNLMAILGL-VRNKKYSNAKCLR 421
            GLS +V  D YGVFPL  KLLN    S ++L   KEIQN+  I+GL + +K   + K LR
Sbjct: 510  GLS-IVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDITDKNKDDIKGLR 568

Query: 422  YGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKG 481
            YG LM+M +QD DG+H KGLLIN  + FWPSLLK   F+S F  PI+KV        K  
Sbjct: 569  YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQ-------KGS 621

Query: 482  KELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYFQDLGKHRAYFVWD-D 538
            +E SF ++ +YE WK+        W+IKY +GL  S+ +E ++YF D+  H+  F+W  D
Sbjct: 622  QEYSFFTIAEYEQWKENTNLLG--WKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGD 679

Query: 539  KDETSIKLAFSKKA-EEWEAWIGNSQPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSI 596
            +D  SI +AFSKK  E+ + W+ N   G+  +++ K ++Y +FVNKEL++ S  + +RSI
Sbjct: 680  RDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSI 739

Query: 597  PSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDF 656
            P+++DG   GQRK L+  F+ NL  + +V +L  Y+ EHS  H+G+ S+  TII MAQ F
Sbjct: 740  PNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTF 799

Query: 657  VGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRS 716
            VGSNNIN L P GQFG+R  GGKD +++R ++ KL   TR +F   DD +L+YLNE+G+ 
Sbjct: 800  VGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQK 859

Query: 717  IQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGF 776
            I+P +YIP+IP +LVNGC  +GT +SS IP Y+  +II N++R++N E ++ M PWYK F
Sbjct: 860  IEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDF 919

Query: 777  GGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITA---RGLIES 833
             G IE + K  GY T+ G++ +I+  T  I ELPI+ WT+DYK+FLE++       LI  
Sbjct: 920  KGRIESNGK-TGYETI-GIINKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLILD 977

Query: 834  FRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTP 893
            +     +E + F + +   ++   E +E L K F L  T++T+NM LFD   K+++Y+T 
Sbjct: 978  YIDNSSHEDICFTIKMDPAKLQKAE-EEGLEKVFKLKSTLTTTNMTLFDPNLKLQRYSTE 1036

Query: 894  EQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIE 953
              IL+EFC  RLK Y  RK YL+    +  R +  K KFI  IVN +     ++ ++L+E
Sbjct: 1037 LDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLVE 1096

Query: 954  ILKKGKSAEPHVAGAIDYSS-KEQEAGEQESVSQSVS-------IEGATLGDYEYLSSLP 1005
             L + K  +P+     D +  K++E  EQE +  + +       I G T+ DY+YL S+P
Sbjct: 1097 ELYR-KGYDPYK----DINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSMP 1151

Query: 1006 FENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
              + TLE ++ L  +L EKE EL+ L + + + MWL D+E  E+  +
Sbjct: 1152 IFSLTLEKVEDLLTQLKEKERELEILRNITVETMWLKDIEKVEEAIE 1198



 Score = 54.3 bits (129), Expect = 2e-05
 Identities = 31/68 (45%), Positives = 43/68 (62%), Gaps = 5/68 (7%)

Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
           NGK +  V FKPDL+KF M  ++ D+ +L+ KRV D+A  C   +V V LNG  + VK F
Sbjct: 193 NGKDYVKVTFKPDLNKFGMTEMDDDIESLLFKRVYDLAGTC---SVRVYLNGQRLAVKDF 249

Query: 185 KDYANFFL 192
           K Y + +L
Sbjct: 250 KSYVDLYL 257


>UniRef100_P41001 DNA topoisomerase II [Plasmodium falciparum]
          Length = 1398

 Score =  630 bits (1626), Expect = e-179
 Identities = 372/888 (41%), Positives = 537/888 (59%), Gaps = 63/888 (7%)

Query: 210  RLEICLSLSDG-KFQQVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKKKH--VNVNAD 266
            R EI +S SDG +FQQVSFVNSI T KGG+HV+YI +Q+ + + K+   K    + + + 
Sbjct: 330  RWEIVVSKSDGSQFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGGMEIKSG 389

Query: 267  TVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLK-FFPGSMLNDVQKSQILDNLLPR 325
             ++N LWVFVN LI NP F+SQTKE LTTKP + G K       +N+V KS IL N+L  
Sbjct: 390  HIRNHLWVFVNCLIVNPTFDSQTKETLTTKPVKFGSKCILSDKTINNVLKSPILSNILLW 449

Query: 326  IPFKHRTHV----------------------DAKLAGRPDSGKCTLILTQGQYVKDLAMS 363
               K +  +                      DA  AG   S +CTLILT+G   K   ++
Sbjct: 450  AQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLILTEGDSAKTSCLA 509

Query: 364  GLSAVVDPDLYGVFPLSSKLLNATRDS-RKLFKKKEIQNLMAILGL-VRNKKYSNAKCLR 421
            GLS +V  D YGVFPL  KLLN    S ++L   KEIQN+  I+GL + +K   + K LR
Sbjct: 510  GLS-IVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDITDKNKDDIKGLR 568

Query: 422  YGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKG 481
            YG LM+M +QD DG+H KGLLIN  + FWPSLLK   F+S F  PI+KV        K  
Sbjct: 569  YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQ-------KGS 621

Query: 482  KELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYFQDLGKHRAYFVWD-D 538
            +E SF ++ +YE WK+        W+IKY +GL  S+ +E ++YF D+  H+  F+W  D
Sbjct: 622  QEYSFFTIAEYEQWKENTNLLG--WKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGD 679

Query: 539  KDETSIKLAFSKKA-EEWEAWIGNSQPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSI 596
            +D  SI +AFSKK  E+ + W+ N   G+  +++ K ++Y +FVNKEL++ S  + +RSI
Sbjct: 680  RDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSI 739

Query: 597  PSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHS-YCHYGQQSIASTIIGMAQD 655
            P+++DG   GQRK L+  F+ NL  + +V +L  Y+ EHS Y H+G+ S+  TII MAQ 
Sbjct: 740  PNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHHGESSLQQTIINMAQT 799

Query: 656  FVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGR 715
            FVGSNNIN L P GQFG+R  GGKD +++R ++ KL   TR +F   DD +L+YLNE+G+
Sbjct: 800  FVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQ 859

Query: 716  SIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKG 775
             I+P +YIP+IP +LVNGC  +GT +SS IP Y+  +II N++R++N E ++ M PWYK 
Sbjct: 860  KIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKD 919

Query: 776  FGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITA---RGLIE 832
            F G IE + K  GY T+ G++ +I+  T  I ELPI+ WT+DYK+FLE++       LI 
Sbjct: 920  FKGRIESNGK-TGYETI-GIINKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLIL 977

Query: 833  SFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNT 892
             +     +E + F + +   ++   E +E L K F L  T++T+NM LFD   K+++Y+T
Sbjct: 978  DYIDNSSHEDICFTIKMDPAKLQKAE-EEGLEKVFKLKSTLTTTNMTLFDPNLKLQRYST 1036

Query: 893  PEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLI 952
               IL+EFC  RLK Y  RK YL+    +  R +  K KFI  IVN +     ++ ++L+
Sbjct: 1037 ELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLV 1096

Query: 953  EILKKGKSAEPHVAGAIDYSS-KEQEAGEQESVSQSVS-------IEGATLGDYEYLSSL 1004
            E L + K  +P+     D +  K++E  EQE +  + +       I G T+ DY+YL S+
Sbjct: 1097 EELYR-KGYDPYK----DINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSM 1151

Query: 1005 PFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
            P  + TLE ++ L  +L EKE EL+ L + + + MWL D+E  E+  +
Sbjct: 1152 PIFSLTLEKVEDLLTQLKEKERELEILRNITVETMWLKDIEKVEEAIE 1199



 Score = 54.3 bits (129), Expect = 2e-05
 Identities = 31/68 (45%), Positives = 43/68 (62%), Gaps = 5/68 (7%)

Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
           NGK +  V FKPDL+KF M  ++ D+ +L+ KRV D+A  C   +V V LNG  + VK F
Sbjct: 193 NGKDYVKVTFKPDLNKFGMTEMDDDIESLLFKRVYDLAGTC---SVRVYLNGQRLAVKDF 249

Query: 185 KDYANFFL 192
           K Y + +L
Sbjct: 250 KSYVDLYL 257


>UniRef100_Q6PUA4 DNA topoisomerase type 2 [Tetrahymena thermophila]
          Length = 1402

 Score =  629 bits (1622), Expect = e-178
 Identities = 379/967 (39%), Positives = 564/967 (58%), Gaps = 68/967 (7%)

Query: 128  GKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDY 187
            G +T V F PDL KF M+N+  D+  L++KRV DMA      V V LN   I +KSF  Y
Sbjct: 195  GNFTCVTFYPDLSKFKMQNISDDMANLLRKRVYDMAGIFNNKVKVYLNNEQIKIKSFSQY 254

Query: 188  ANFFLDRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQI 247
             N F+   +            DR EI ++ SDG+F+QVSFVN I T +GG HVD++  +I
Sbjct: 255  VNLFIPDIEEQYKCYDPTMTSDRWEILVTFSDGQFKQVSFVNGICTSRGGKHVDFVIDKI 314

Query: 248  TTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLK-FF 305
               +++++LKK K +++    +K  L++F+N LI NP+F+SQTK+ LTTK +  G K   
Sbjct: 315  VERMQEQILKKNKDLDIKPHQIKQNLFIFMNCLIVNPSFDSQTKDTLTTKASAFGSKPEL 374

Query: 306  PGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKLAGRPDSGK 346
                +  +  + I++ ++ +   +    +                   DA  AG   S  
Sbjct: 375  SEKFIKKILGTGIIEQIVSQAKARQNAKLAKTLKGGKKGRITGIPKLDDANDAGTARSEN 434

Query: 347  CTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQNLMAI 405
            CTLILT+G   K LAM+G+  VV  D YGVFPL  KLLN    ++K + + +EIQN+  I
Sbjct: 435  CTLILTEGDSAKALAMAGIE-VVGRDNYGVFPLKGKLLNVREANKKQIIENQEIQNICKI 493

Query: 406  LGL---VRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSV 462
            +GL   V+N  Y N K LRYG LM+MA+QD DG+H KGL+INF + FWPSL K+  F+  
Sbjct: 494  IGLDPAVQN--YENTKQLRYGSLMIMADQDSDGSHIKGLVINFIHHFWPSLFKMKGFLKE 551

Query: 463  FTFPIIKVSMYNASDSKKGKEL-SFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQE 519
            F  PI+KV+        KG E+ SF ++Q ++++  + G+    +++KY +GL  S+ +E
Sbjct: 552  FITPILKVT--------KGDEVHSFFTIQDFKNFAAQKGDRLKQYKVKYYKGLGTSTDKE 603

Query: 520  VREYFQDLGKHRAYFVW-DDKDETSIKLAFS-KKAEEWEAWIGNSQPGT-CNYERKVINY 576
             +EYF +  KH+  F + D+ D  +I+L FS KK +E + W+ N  P +  +Y  K +  
Sbjct: 604  AKEYFSNFYKHQINFQYLDENDMEAIELGFSGKKIKERKDWLANYDPNSFVDYNIKQLRS 663

Query: 577  RNFVNKELL-FSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEH 635
            + F+++EL+ FS+  NL RSIPS+ DGL  GQRK LF  F+ NL  + +V +L  YV EH
Sbjct: 664  KXFIDRELIHFSNADNL-RSIPSLCDGLKPGQRKILFSCFKRNLKSEIKVAQLIGYVAEH 722

Query: 636  SYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVT 695
            S  H+G+QS+ASTIIGMAQ+FVGSNNINL++P GQFGTR+ GGK+HAS+R ++  L+ +T
Sbjct: 723  SAYHHGEQSLASTIIGMAQNFVGSNNINLMMPIGQFGTRNQGGKEHASARYIFTSLSKIT 782

Query: 696  RLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIK 755
            R+LFP  DD +L+YL +D + ++P WY+PIIP+ LVNG   +GT +S+DIP Y+   I++
Sbjct: 783  RILFPEHDDHVLKYLEDDNQVVEPEWYMPIIPMCLVNGSSGIGTGWSTDIPNYNHKGIVE 842

Query: 756  NVRRFLNNEEMVSMKPWYKGFGGTIEKSAKG----IGYYTVDGLVERINEQTFRIKELPI 811
             +R  L       + PWYKGF G IE + KG     G Y +D +     E+T +I ELP+
Sbjct: 843  QIRGKLEGRPFTELHPWYKGFQGQIEINPKGGYIVKGQYEIDEV-----EETIKITELPV 897

Query: 812  RMWTEDYK-----KFLEKITARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKK 866
              WT DYK     + L        IE  R+      V+F+V   Q     I++  ++ KK
Sbjct: 898  GKWTRDYKVVLIQELLSPPKGEPEIEDIREYHTNNRVHFEV---QAIPGRIQQWGDIEKK 954

Query: 867  FNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSL 926
              L+ T+ T+N+ +F+ + K+K+Y +  +I+EEF  LRLK Y +RK YLV    + +  L
Sbjct: 955  LKLSTTMQTTNIVMFNDKYKLKRYQSTVEIMEEFYALRLKCYQKRKDYLVSKIQRDVDIL 1014

Query: 927  RIKQKFISNIVNEKFNPINRRAELLIEILKK------GKSAEPHVAGAIDYSSKEQEAGE 980
            + K KFI+ +VN      N R + ++  LK+       K    +    +D   +E +  E
Sbjct: 1015 QNKMKFITLVVNGTLEIRNARKKGVLNKLKELGLTPMSKITRINSTKNLDNEDEEVQQDE 1074

Query: 981  QESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMW 1040
            +E   Q V      L +Y YL S+P  + T E + +L+ +++EKE+EL  L+      MW
Sbjct: 1075 EEEEEQ-VQEGEIPLSEYNYLLSMPIFSLTEEKVLQLKKQVEEKESELLILQKKEIKDMW 1133

Query: 1041 LNDLELF 1047
              DL+ F
Sbjct: 1134 TEDLDKF 1140


>UniRef100_Q8X1U4 DNA topoisomerase II [Aspergillus niger]
          Length = 1391

 Score =  627 bits (1618), Expect = e-178
 Identities = 376/962 (39%), Positives = 555/962 (57%), Gaps = 51/962 (5%)

Query: 130  WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
            +  V FKPD  KF M  ++ D  AL+K+RV D+A      V V LNGT IP++ FK Y  
Sbjct: 244  YAKVTFKPDYAKFGMDGMDDDFEALVKRRVYDLAGTA--KVNVKLNGTRIPIRGFKKYME 301

Query: 190  FFL-----DRAKPFPLPRTH---AKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVD 241
             +      +R    P P+          R E+  ++SDG FQQVSFVNSIAT  GGTHV+
Sbjct: 302  MYTKAIRKERGDTGPAPKDEIITCSPDPRWEVGFAVSDGAFQQVSFVNSIATTSGGTHVN 361

Query: 242  YITKQITTYIKKEVLKKKHVNVNADT--VKNQLWVFVNALIDNPAFNSQTKEMLTTKPAR 299
            YI  +I   + ++V KK        T  ++N +++FVNALI NPAF SQTKE LTTK ++
Sbjct: 362  YIADRICNRLAEQVKKKNKNGATLKTAQIRNHIFIFVNALIVNPAFTSQTKEQLTTKASQ 421

Query: 300  LGLK-FFPGSMLNDVQKSQILDNLLP-----------------RIPFKHRTHVDAKLAGR 341
             G K          V K+ ++DN+L                  R    +    DA  AG 
Sbjct: 422  FGSKCVLDEDFYKKVLKTAVMDNILHFAQQKADQMLKKTDGGRRSRMNNPKLTDANKAGT 481

Query: 342  PDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR--KLFKKKEI 399
             D   CTLILT+G   K LAM+G  AVV PDL+GVFPL  KLLN  RD+   ++ K +EI
Sbjct: 482  KDGHHCTLILTEGDSAKGLAMAG-RAVVGPDLFGVFPLRGKLLNV-RDASFDQISKNQEI 539

Query: 400  QNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKF 459
            QN+   LGL   K+Y++ + LRYG LM+M +QD DG+H KGLLINF  + +PSLLK+ +F
Sbjct: 540  QNIKNFLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLKIPEF 599

Query: 460  MSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSA 517
            +  F  PI+KV  +        K+ SF +M +YE W +E  +    W+ KY +GL  S+ 
Sbjct: 600  LIEFITPIVKV--WKGDPKNPTKQRSFFTMPEYEAWAEEHQHERG-WDHKYYKGLGTSTT 656

Query: 518  QEVREYFQDLGKH-RAYFVWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGT-CNYERKVI 574
            ++ + YF+DL +H + +    D +   I+LAFSKK A+E + W+   +PGT  ++  + I
Sbjct: 657  EDAQVYFRDLDRHLKEFHTMQDNEAELIELAFSKKKADERKEWLRQFKPGTFLDHSVEKI 716

Query: 575  NYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTE 634
             Y +F+NKEL+  SM +  RSIPSVVDGL  GQRK L+  F  NL K  +V  L  +V+ 
Sbjct: 717  TYTDFINKELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSG 776

Query: 635  HSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCV 694
             +   +G  S+  TI+G+AQ FVGSNNIN L P G FG+R  GG D AS+R +Y +L+  
Sbjct: 777  MTAYQHGDVSLQQTIVGLAQTFVGSNNINCLEPSGNFGSRLQGGSDCASARYIYTRLSPF 836

Query: 695  TRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEII 754
             R +F   D+ LL Y  +DG++I+P  Y+P++P++L+NG   +GT +SS IP Y+P +++
Sbjct: 837  ARRIFHASDEPLLTYNVDDGKTIEPEVYMPVVPMILINGADGIGTGWSSSIPNYNPEDVV 896

Query: 755  KNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMW 814
             N++R +N EE+  M+PW++GF G  E ++ G   +   G+++   E+   I ELPIR W
Sbjct: 897  DNLKRLMNGEEIKPMQPWFRGFTG--EVTSIGGDRFKFSGIIKETGEKEVEITELPIRTW 954

Query: 815  TEDYKKFLEKI----TARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLT 870
            T+D+K  LE I         I+ ++    +  V+F + + ++ + +   +E L +KF LT
Sbjct: 955  TQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHLKS-AVEEGLEEKFKLT 1013

Query: 871  CTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQ 930
             TI+T+N+  FD EG+I KY T + IL+EF  +RLKYY RRKQY +    + L  L  + 
Sbjct: 1014 KTIATTNLVAFDPEGRITKYATVDDILKEFFAVRLKYYERRKQYQLNEMQKELEKLSNQA 1073

Query: 931  KFISNIVN-EKFNPINRRAELLIEILKKGKSAEPHVAGAIDYSSKEQEAGEQESVSQSVS 989
            +F+  I++ E      ++  L++E+  KG    P VA A   + + + A E E  S+ V 
Sbjct: 1074 RFVQMIIDGELVVSKKKKNVLVVELKDKGFKPFPKVADAAK-AGEAEPAAEDEEESEDVD 1132

Query: 990  IEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEK 1049
                    Y+YL  +   + T E +++L  ++ +KE E+ TL   S + +W  DL+ F  
Sbjct: 1133 DTSNLSNAYDYLLGMAIWSLTQERVERLRRQIGDKEMEIDTLIKLSKEDIWKRDLDDFIN 1192

Query: 1050 EF 1051
            E+
Sbjct: 1193 EW 1194


>UniRef100_UPI00003AC994 UPI00003AC994 UniRef100 entry
          Length = 1553

 Score =  624 bits (1609), Expect = e-177
 Identities = 396/989 (40%), Positives = 571/989 (57%), Gaps = 88/989 (8%)

Query: 126  DNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
            D   +T V F+PDL KF M  L+KD++ALM +R  D+A   G T  V V LNG  +PVK 
Sbjct: 211  DGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIA---GSTKDVKVFLNGKRLPVKG 267

Query: 184  FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
            F+ Y + +L D+       L   H ++  R E+CL+LS+  FQQVSFVNSIAT KGG HV
Sbjct: 268  FRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEKGFQQVSFVNSIATTKGGRHV 327

Query: 241  DYITKQITTYIKKEVLKKKHVN---VNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
            DY+  QI T +  +V+KKK+ N   V    VKN +W+FVN+LI+NP F+SQTKE +T + 
Sbjct: 328  DYVADQIVTKLI-DVVKKKNKNGVGVKPFQVKNHMWIFVNSLIENPTFDSQTKENMTLQA 386

Query: 298  ------ARLGLKFFPGSMLNDVQKSQILDNLLPRIPFKHRTHV----------------- 334
                   +L  KF  G++        I++++L  + FK +T +                 
Sbjct: 387  KSFGSTCKLSEKFIKGAV-----GCGIVESILNWVKFKAQTQLNKKCSAVKHTKIKGVPK 441

Query: 335  --DAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK 392
              DA  AG  +S  CTLILT+G   K LA+SGL  VV  D YGVFPL  K+LN    S K
Sbjct: 442  LDDANDAGSKNSIDCTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKMLNVREASHK 500

Query: 393  -LFKKKEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYS 448
             + +  EI N++ I+GL   K Y +    K LRYG++M+M +QD+DG+H KGLLINF + 
Sbjct: 501  QIMENAEINNIIKIVGLQYKKNYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHH 560

Query: 449  FWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEI 508
             WPSLL+   F+  F  PIIKVS       K  +E+ F S+ ++E+WK    N  N W+I
Sbjct: 561  NWPSLLR-HNFLEEFITPIIKVS-------KNKEEIPFYSIPEFEEWKSSTQNY-NSWKI 611

Query: 509  KYCQGL--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKK-AEEWEAWIGNSQ- 563
            KY +GL  S+++E +EYF D+ +HR  F +   +D+ +I LAFSKK  EE + W+ N   
Sbjct: 612  KYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPEDDAAITLAFSKKKVEERKEWLTNFME 671

Query: 564  ----------PGTCNY--ERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTL 611
                      P    Y  +   + Y +F+NKEL+  S  + +RSIPS+VDGL  GQRK L
Sbjct: 672  DRRQRKLHGLPEDYLYGKDTNYLTYNDFINKELVLFSNSDNERSIPSLVDGLKPGQRKVL 731

Query: 612  FCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQF 671
            F  F+ N  ++ +V +L   V E S  H+G+ S+  TII +AQ+FVGSNN+NLL P GQF
Sbjct: 732  FTCFKRNDKREVKVAQLAGSVAEMSSYHHGEASLMMTIINLAQNFVGSNNLNLLQPIGQF 791

Query: 672  GTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLV 731
            GTR  GGKD AS R ++  L+ + RLLFP  DD +L +L +D + ++P WY+PIIP+VL+
Sbjct: 792  GTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDNVLRFLYDDNQRVEPEWYMPIIPMVLI 851

Query: 732  NGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYT 791
            NG   +GT +S  IP +   E + N+R  L+ +E + M P YK F GTI++   G   Y 
Sbjct: 852  NGAEGIGTGWSCKIPNFDIRETVNNIRCLLDGKEPLPMLPSYKNFKGTIDE--LGPNQYV 909

Query: 792  VDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNF 845
            + G V  ++  T  I ELP+R WT+ YK+ + +    G      LI  +++      V F
Sbjct: 910  ISGEVSILDSTTIEITELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYKEYHTDTTVKF 969

Query: 846  KVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRL 905
             V + +E++A  E    L K F L   ++ ++M LFD  G +KKY +P+ IL+EF  LRL
Sbjct: 970  VVKMSEEKLAEAEA-VGLHKVFKLQTNLTCNSMVLFDHVGFLKKYESPQDILKEFFELRL 1028

Query: 906  KYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPH 964
            +YY  RK++L+         L  + +FI   ++ K    N+  + LI++L ++G  ++P 
Sbjct: 1029 RYYGLRKEWLIGMLGAESAKLNNQARFILEKIDGKIVIENKPKKELIQVLIQRGYESDP- 1087

Query: 965  VAGAIDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEK 1024
            V    +  +KE+E G+ ES  +S +   AT  D+ YL ++P    T E   +L  + D K
Sbjct: 1088 VKAWKELQNKEEEEGD-ESGEESAA---ATGPDFNYLLNMPLWYLTKEKKDELCKQRDNK 1143

Query: 1025 ENELKTLEHTSPDLMWLNDLELFEKEFDV 1053
            + EL+ L+H SP  +W  DL  F +E DV
Sbjct: 1144 DKELEDLKHKSPSDLWKEDLAAFVEELDV 1172


>UniRef100_Q8X1U6 DNA topoisomerase II [Aspergillus flavus]
          Length = 1219

 Score =  624 bits (1608), Expect = e-177
 Identities = 382/965 (39%), Positives = 555/965 (56%), Gaps = 57/965 (5%)

Query: 130  WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
            +T V FKPD  KF M  ++ D  AL+K+RV D+A      V V LNG+ +PV++FK Y  
Sbjct: 207  YTKVTFKPDYAKFGMDGMDNDFEALVKRRVYDLAGTA--KVAVKLNGSRVPVRNFKKYME 264

Query: 190  FFL-----DRAKPFPLPRTH---AKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVD 241
             +      +R    P  +          R E+  ++SDG FQQVSFVNSIAT  GGTHV+
Sbjct: 265  MYTKAIRRERGDDGPAAKDEIITCSPDPRWEVGFAVSDGSFQQVSFVNSIATTSGGTHVN 324

Query: 242  YITKQITTYIKKEVLKKKHVNVNADTVK-----NQLWVFVNALIDNPAFNSQTKEMLTTK 296
            YI  QI + +  +V KK   N N  T+K     N +++FVNA I NPAF SQTKE LTTK
Sbjct: 325  YIADQICSKLADQVKKK---NKNGATLKPAQIRNHIFIFVNAQIVNPAFTSQTKEQLTTK 381

Query: 297  PARLGLK------FFPGSMLNDVQKS------QILDNLLPRIPFKHRTHV------DAKL 338
             ++ G K      F+   +  DV  +      Q  D +L +     R  +      DA  
Sbjct: 382  SSQFGSKCVLEEDFYKKILKTDVMSNILHFAQQKADQMLKKTDGGRRARMNNPKLTDANK 441

Query: 339  AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDS--RKLFKK 396
            AG  D   CTLILT+G   K LAM+G  AVV PDL+GVFPL  KLLN  RD+   ++ K 
Sbjct: 442  AGTKDGHHCTLILTEGDSAKGLAMAG-RAVVGPDLFGVFPLRGKLLNV-RDATFEQISKN 499

Query: 397  KEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKV 456
             EIQN+   LGL   K+Y++ + LRYG LM+M +QD DG+H KGLLINF  + +PSLL++
Sbjct: 500  AEIQNIKNFLGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINFLQAQFPSLLRI 559

Query: 457  SKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL-- 514
             +F+  F  PIIKV  +        K+ SF +M +YE WK+E  +    WE KY +GL  
Sbjct: 560  PEFLIEFITPIIKV--WKGDPKNPTKQRSFFTMPEYEAWKEEHKHERG-WEHKYYKGLGT 616

Query: 515  SSAQEVREYFQDLGKH-RAYFVWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGT-CNYER 571
            S+ ++ + YF+DL +H + +    D +   I+LAFSKK A+E + W+   +PGT  ++  
Sbjct: 617  STTEDAQVYFRDLDRHLKEFHTMQDNEVGLIELAFSKKKADERKEWLRQFKPGTFLDHSV 676

Query: 572  KVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAY 631
              I+Y +F+NKEL+  SM +  RSIPSVVDGL  GQRK L+  F  NL K  +V  L  +
Sbjct: 677  SKISYTDFINKELILFSMADNVRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGH 736

Query: 632  VTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKL 691
            V+  +   +G  S+  TI+G+AQ FVGSNN+N L P G FG+R  GG D AS+R +Y +L
Sbjct: 737  VSGMTAYQHGDISLQQTIVGLAQSFVGSNNVNCLEPSGNFGSRLQGGSDCASARYIYTRL 796

Query: 692  NCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPY 751
            +   R +F   DD LL Y  +DG  I+P  Y+P++P++LVNG   +GT +SS IP Y+P 
Sbjct: 797  SPFARRVFHAHDDPLLTYNEDDGEKIEPEIYVPVVPMILVNGADGIGTGWSSSIPNYNPE 856

Query: 752  EIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPI 811
            +I+ N++R ++ EE   M+PW++GF G  E +  G   +   G+++   E+   I ELPI
Sbjct: 857  DIVDNLKRLMDGEETRPMQPWFRGFTG--EVTDVGGDRFKFSGIIKETGEKEVEITELPI 914

Query: 812  RMWTEDYKKFLEKI----TARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKF 867
            R WT+D+K  LE I         I+ ++    +  V+F + + ++ + +    E L +KF
Sbjct: 915  RTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQLDEKNMKS-ALSEGLEEKF 973

Query: 868  NLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLR 927
             L+ T++T+N+  FD EG+I KY T + IL+EF T RLK+Y +RKQY +    + L  L 
Sbjct: 974  KLSKTVATTNLVAFDPEGRITKYATVDDILKEFYTYRLKFYEKRKQYQLSQLQKELDKLS 1033

Query: 928  IKQKFISNIVNEKFNPINRRAELLIEILK-KGKSAEPHVAGAIDYSSKEQEAGEQESVSQ 986
             + +F+  I++ K     ++  +L++ LK KG  A P VA A+    +E+   E +  S 
Sbjct: 1034 NQARFVQEIIDGKLVVSKKKKNVLVQELKDKGYKAFPKVAEAVKAGEEERVVEEDDDESD 1093

Query: 987  SVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLEL 1046
            S   E      Y+YL  +   + T E ++KL  ++ EKE E+  L   S + +W  DL+ 
Sbjct: 1094 SQDTE-VLSSAYDYLLGMAIWSLTQERVEKLRRQIGEKEVEVDALIKMSKEDIWKRDLDD 1152

Query: 1047 FEKEF 1051
            F  E+
Sbjct: 1153 FIAEW 1157


>UniRef100_Q9NEE4 DNA topoisomerase II [Leishmania major]
          Length = 1497

 Score =  621 bits (1602), Expect = e-176
 Identities = 365/984 (37%), Positives = 559/984 (56%), Gaps = 64/984 (6%)

Query: 125  CDNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSF 184
            CD+  +T V F PD   F +    +D++ +MK+RV D+A C  +T+   LN   I   +F
Sbjct: 184  CDSADYTMVTFYPDFALFHVDKFTEDMLLMMKRRVYDIAGCTDKTLKCFLNDERIACTTF 243

Query: 185  KDYANFFLDRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYIT 244
             +Y + +    +      +++++ DR E+C+ +S+   QQVSFVNSIAT +GGTHV YI 
Sbjct: 244  PEYVDLYPTMGEERKAA-SYSRVNDRWEVCVRVSNIGPQQVSFVNSIATTRGGTHVKYIM 302

Query: 245  KQITTYIKKEVLKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLKF 304
             QIT+ + ++  KKK  +V    ++  +++FVN LI+NP F+SQTKE L T  ++ G   
Sbjct: 303  DQITSKVMEQAKKKKKTDVKPHMIRPHIFLFVNCLIENPGFDSQTKETLNTVKSKFGSTC 362

Query: 305  -FPGSMLNDVQKSQILDN------------LLPRIPFKHRTHV-------DAKLAGRPDS 344
              P S+++ +  S I++             +  ++    R  +       DA  AG   S
Sbjct: 363  DLPNSIVDYIMSSGIVERSVEMANSKIAREMASKMRSSDRKQIMGIPKLDDANEAGGKHS 422

Query: 345  GKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDS-RKLFKKKEIQNLM 403
             +CTLILT+G   K L  +GL AV D D +GVFPL  K LN    S +KL   +EIQ +M
Sbjct: 423  HRCTLILTEGDSAKTLCTAGL-AVKDRDYFGVFPLRGKPLNVREASLKKLAACEEIQCVM 481

Query: 404  AILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVF 463
             I+GL   + Y N+  LRYG LM+M++QD DG+H KGLLINF + FWP+LL+V  F+  F
Sbjct: 482  KIMGLDIRQTYENSDGLRYGHLMIMSDQDHDGSHIKGLLINFIHCFWPNLLRVPGFLQQF 541

Query: 464  TFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVR 521
              PI+K        +  GK +SF SM  Y +WKK +G+  ++++I+Y +GL  S A+E R
Sbjct: 542  ITPIVKARPKGRGGA--GKAISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGR 599

Query: 522  EYFQDLGKHRAYFVWDDK-DETSIKLAFSK-KAEEWEAWIGNSQPG-----TCNYERKVI 574
            EYF+++ +HR  FV  ++ +E  I +AF K + E+ + WI N +       + +Y  + +
Sbjct: 600  EYFENIDRHRLNFVEQEQSEEDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYNVRQV 659

Query: 575  NYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTE 634
            +YR+FV+KEL+  S+ + +RSIPSV+DG   GQRK LF  F+ NL    +V +L  YV+E
Sbjct: 660  SYRDFVDKELILFSIADCERSIPSVIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSE 719

Query: 635  HSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCV 694
            HS  H+G+QS+  TI+GMAQDFVGSNN+ LL   GQFGTR  GGKDHA+ R ++ +L  V
Sbjct: 720  HSAYHHGEQSLVQTIVGMAQDFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMQV 779

Query: 695  TRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEII 754
             R +F   DD ++EY ++DG S++P +YIP+IP+VLVNG   +GT FS+ IP Y+P EII
Sbjct: 780  ARAIFHPADDFVVEYKDDDGLSVEPFFYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEII 839

Query: 755  KNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMW 814
             N+ R +  EE+  M+PWY GF GT+E+  K  G +   G  E   +    I ELPI +W
Sbjct: 840  SNLERLMRGEEVHKMQPWYFGFTGTMEE--KEPGKFISHGRYEIRPDGVVCITELPIGVW 897

Query: 815  TEDYKKFLEKITARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTIS 874
            T+ YKKFLE +  + L+  +R+      V+F+V +  + +      + + ++  L   + 
Sbjct: 898  TQAYKKFLEDMREKELVVQYREHTTDVTVDFEVFLHPQVLEQWVAQDVVEERLQLKEYVH 957

Query: 875  TSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFIS 934
             +N+  F+ EG+I KY+  E +L+EF  +RL YY +RKQYL+    +L   L    +F+ 
Sbjct: 958  ATNIIAFNKEGQITKYSDAESVLKEFYLVRLDYYAKRKQYLLGELRRLTSKLENMVRFVR 1017

Query: 935  NIVNEKFNPINRRAELLIEILKKGK--SAEPHVAGAIDYSSKEQEAGEQESVSQSVSIEG 992
             +V        R+ + L+E L++       PH    +  SS   E G+ E    + + E 
Sbjct: 1018 EVVEGTLVVTKRKKKELLEDLQRRMYLPFPPHTKKKL--SSTTVEEGDDEGAPDAQNSEE 1075

Query: 993  ATLG------------------------DYEYLSSLPFENFTLESLKKLEAELDEKENEL 1028
              LG                        DY+YL  +   + T E + +LEA++     + 
Sbjct: 1076 DVLGVGNAADSGADDGAAEPPEMRRATRDYDYLLGMKLWSLTAEMIARLEAQMARARRDT 1135

Query: 1029 KTLEHTSPDLMWLNDLELFEKEFD 1052
              +E  +P  MW+ DL++   + +
Sbjct: 1136 AAMEARTPKDMWMEDLKVLRTKLE 1159


>UniRef100_O55079 Topoisomerase II alpha [Homo sapiens]
          Length = 1526

 Score =  621 bits (1601), Expect = e-176
 Identities = 390/987 (39%), Positives = 569/987 (57%), Gaps = 80/987 (8%)

Query: 127  NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
            NG+ +T + F+PDL KF M++L+KD++ALM +R  D+A   G T  V V LNG  +PVK 
Sbjct: 209  NGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNKLPVKG 265

Query: 184  FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
            F+ Y + +L D+       L   H ++  R E+CL++S+  FQQ+SFVNSIAT KGG HV
Sbjct: 266  FRSYVDMYLKDKLDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHV 325

Query: 241  DYITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
            DY+  QI + +  +V+KKK+   V V A  VKN +W+FVNALI+NP F+SQTKE +T + 
Sbjct: 326  DYVADQIVSKLV-DVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQA 384

Query: 298  ARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAK 337
               G         +       I++++L  + FK +  +                   DA 
Sbjct: 385  KSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDAN 444

Query: 338  LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKK 396
             AG  +S +CTLILT+G   K LA+SGL  VV  D YGVFPL  K+LN    S K + + 
Sbjct: 445  DAGSRNSTECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLGGKILNVREASHKQIMEN 503

Query: 397  KEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSL 453
             EI N++ I+GL   K Y +    K LRYG++M+M +QD+DG+H KGLLINF +  WPSL
Sbjct: 504  AEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 563

Query: 454  LKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQG 513
            L+  +F+  F  PI+KVS       K  +EL+F S+ ++E+WK    N    W++KY +G
Sbjct: 564  LR-HRFLEEFITPIVKVS-------KNKQELAFYSLPEFEEWKSSTPNHKK-WKVKYYKG 614

Query: 514  L--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKKA----EEW----------E 556
            L  S+++E +EYF D+ +HR  F +   +D+ +I LAFSKK     +EW           
Sbjct: 615  LGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTHFMEDRRQR 674

Query: 557  AWIGNSQPGTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFE 616
              +G  +          + Y +F+NKEL+  S  + +RSIPS+VDGL  GQRK LF  F+
Sbjct: 675  KLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFK 734

Query: 617  MNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDL 676
             N  ++ +V +L   V E S  H+G+ S+  TII +AQ+FVGSNN+NLL P GQFGTR  
Sbjct: 735  RNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLH 794

Query: 677  GGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHA 736
            GGKD AS R ++  L+ +TRLLFP  DD  L++L +D + ++P WYIPIIP+VL+NG   
Sbjct: 795  GGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEG 854

Query: 737  MGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLV 796
            +GT +S  IP +   E++ N+RR L+ EE + M P YK F GTIE+ A     Y ++G V
Sbjct: 855  IGTGWSCKIPNFDIREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELAS--NQYVINGEV 912

Query: 797  ERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVNVK 850
              +N  T  I ELPIR WT+ YK+ + +    G      LI  +R+      V F + + 
Sbjct: 913  AILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMT 972

Query: 851  QEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVR 910
            +E++A  E+   L K F L  +++ ++M LFD  G +KKY+T   IL++F  LRLKYY  
Sbjct: 973  EEKLAEAER-VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILKDFFELRLKYYGL 1031

Query: 911  RKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVAGAI 969
            RK++L+         L  + +FI   ++ K    N+ + EL+  ++++G  ++P  A   
Sbjct: 1032 RKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKE 1091

Query: 970  DYSSKEQEAGEQES---VSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKEN 1026
                   E   +ES    S SV+  G T   + YL  +P    T E   +L  + +EKE 
Sbjct: 1092 AQQKVPDEEENEESDNENSDSVAESGPT---FNYLLDMPLWYLTKEKKDELCKQRNEKEQ 1148

Query: 1027 ELKTLEHTSPDLMWLNDLELFEKEFDV 1053
            EL TL++ SP  +W  DL +F +E +V
Sbjct: 1149 ELNTLKNKSPSDLWKEDLAVFIEELEV 1175


>UniRef100_P41515 DNA topoisomerase II, alpha isozyme [Cricetulus griseus]
          Length = 1526

 Score =  620 bits (1600), Expect = e-176
 Identities = 390/987 (39%), Positives = 569/987 (57%), Gaps = 80/987 (8%)

Query: 127  NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
            NG+ +T + F+PDL KF M++L+KD++ALM +R  D+A   G T  V V LNG  +PVK 
Sbjct: 209  NGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNKLPVKG 265

Query: 184  FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
            F+ Y + +L D+       L   H ++  R E+CL++S+  FQQ+SFVNSIAT KGG HV
Sbjct: 266  FRSYVDMYLKDKLDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHV 325

Query: 241  DYITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
            DY+  QI + +  +V+KKK+   V V A  VKN +W+FVNALI+NP F+SQTKE +T + 
Sbjct: 326  DYVADQIVSKLV-DVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQA 384

Query: 298  ARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAK 337
               G         +       I++++L  + FK +  +                   DA 
Sbjct: 385  KSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDAN 444

Query: 338  LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKK 396
             AG  +S +CTLILT+G   K LA+SGL  VV  D YGVFPL  K+LN    S K + + 
Sbjct: 445  DAGSRNSTECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKILNVREASHKQIMEN 503

Query: 397  KEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSL 453
             EI N++ I+GL   K Y +    K LRYG++M+M +QD+DG+H KGLLINF +  WPSL
Sbjct: 504  AEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 563

Query: 454  LKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQG 513
            L+  +F+  F  PI+KVS       K  +EL+F S+ ++E+WK    N    W++KY +G
Sbjct: 564  LR-HRFLEEFITPIVKVS-------KNKQELAFYSLPEFEEWKSSTPNHKK-WKVKYYKG 614

Query: 514  L--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKKA----EEW----------E 556
            L  S+++E +EYF D+ +HR  F +   +D+ +I LAFSKK     +EW           
Sbjct: 615  LGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTHFMEDRRQR 674

Query: 557  AWIGNSQPGTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFE 616
              +G  +          + Y +F+NKEL+  S  + +RSIPS+VDGL  GQRK LF  F+
Sbjct: 675  KLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFK 734

Query: 617  MNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDL 676
             N  ++ +V +L   V E S  H+G+ S+  TII +AQ+FVGSNN+NLL P GQFGTR  
Sbjct: 735  RNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLH 794

Query: 677  GGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHA 736
            GGKD AS R ++  L+ +TRLLFP  DD  L++L +D + ++P WYIPIIP+VL+NG   
Sbjct: 795  GGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEG 854

Query: 737  MGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLV 796
            +GT +S  IP +   E++ N+RR L+ EE + M P YK F GTIE+ A     Y ++G V
Sbjct: 855  IGTGWSCKIPNFDIREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELAS--NQYVINGEV 912

Query: 797  ERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVNVK 850
              +N  T  I ELPIR WT+ YK+ + +    G      LI  +R+      V F + + 
Sbjct: 913  AILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMT 972

Query: 851  QEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVR 910
            +E++A  E+   L K F L  +++ ++M LFD  G +KKY+T   IL++F  LRLKYY  
Sbjct: 973  EEKLAEAER-VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILKDFFELRLKYYGL 1031

Query: 911  RKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVAGAI 969
            RK++L+         L  + +FI   ++ K    N+ + EL+  ++++G  ++P  A   
Sbjct: 1032 RKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKE 1091

Query: 970  DYSSKEQEAGEQES---VSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKEN 1026
                   E   +ES    S SV+  G T   + YL  +P    T E   +L  + +EKE 
Sbjct: 1092 AQQKVPDEEENEESDNENSDSVAESGPT---FNYLLDMPLWYLTKEKKDELCKQRNEKEQ 1148

Query: 1027 ELKTLEHTSPDLMWLNDLELFEKEFDV 1053
            EL TL++ SP  +W  DL +F +E +V
Sbjct: 1149 ELNTLKNKSPSDLWKEDLAVFIEELEV 1175


>UniRef100_O42130 DNA topoisomerase II, alpha isozyme [Gallus gallus]
          Length = 1553

 Score =  620 bits (1598), Expect = e-176
 Identities = 394/988 (39%), Positives = 569/988 (56%), Gaps = 88/988 (8%)

Query: 126  DNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
            D   +T V F+PDL KF M  L+KD++ALM +R  D+A   G T  V V LNG  +PVK 
Sbjct: 211  DGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIA---GSTKDVKVFLNGKRLPVKG 267

Query: 184  FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
            F+ Y + +L D+       L   H ++  R E+CL+LS+  FQQVSFVNSIAT KGG HV
Sbjct: 268  FRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEKGFQQVSFVNSIATTKGGRHV 327

Query: 241  DYITKQITTYIKKEVLKKKHVN---VNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
            DY+  QI T +  +V+KKK+ N   V    VKN +W+FVN+LI+NP F+SQTKE +T + 
Sbjct: 328  DYVADQIVTKLI-DVVKKKNKNGVGVKPFQVKNHMWIFVNSLIENPTFDSQTKENMTLQA 386

Query: 298  ------ARLGLKFFPGSMLNDVQKSQILDNLLPRIPFKHRTHV----------------- 334
                   +L  KF  G++        I++++L  + FK +T +                 
Sbjct: 387  KSFGSTCKLSEKFIKGAV-----GCGIVESILNWVKFKAQTQLNKKCSAVKHTKIKGVPK 441

Query: 335  --DAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK 392
              DA  AG  +S  CTLILT+G   K LA+SGL  VV  D YGVFPL  K+LN    S K
Sbjct: 442  LDDANDAGSKNSIDCTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKMLNVREASHK 500

Query: 393  -LFKKKEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYS 448
             + +  EI N++ I+GL   K Y +    K LRYG++M+M +QD+DG+H KGLLINF + 
Sbjct: 501  QIMENAEINNIIKIVGLQYKKNYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHH 560

Query: 449  FWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEI 508
             WPSLL+   F+  F  PIIKVS       K  +E+ F S+ ++E+WK    N  N W+I
Sbjct: 561  NWPSLLR-HNFLEEFITPIIKVS-------KNKEEIPFYSIPEFEEWKSSTQNY-NSWKI 611

Query: 509  KYCQGL--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKK-AEEWEAWIGNSQ- 563
            KY +GL  S+++E +EYF D+ +HR  F +   +D+ +I LAFSKK  EE + W+ N   
Sbjct: 612  KYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPEDDAAITLAFSKKKVEERKEWLTNFME 671

Query: 564  ----------PGTCNY--ERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTL 611
                      P    Y  +   + Y +F+NKEL+  S  + +RSIPS+VDGL  GQRK L
Sbjct: 672  DRRQRNVHGLPEDYLYGKDTNYLTYNDFINKELVLFSNSDNERSIPSLVDGLKPGQRKVL 731

Query: 612  FCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQF 671
            F  F+ N  ++ +  +L   V E S  H+G+ S+  TII +AQ+FVGSNN+NLL P GQF
Sbjct: 732  FTCFKRNDKREVKGAQLAGSVAEMSSYHHGEASLMMTIINLAQNFVGSNNLNLLQPIGQF 791

Query: 672  GTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLV 731
            GTR  GGKD AS R ++  L+ + RLLFP  DD +L +L +D + ++P WY+PIIP+VL+
Sbjct: 792  GTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDNVLRFLYDDNQRVEPEWYMPIIPMVLI 851

Query: 732  NGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYT 791
            NG   +GT +S  IP +   E + N+R  L+ +E + M P YK F GTI++   G   Y 
Sbjct: 852  NGAEGIGTGWSCKIPNFDIRETVNNIRCLLDGKEPLPMLPSYKNFKGTIDE--LGPNQYV 909

Query: 792  VDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNF 845
            + G V  ++  T  I ELP+R WT+ YK+ + +    G      LI  +++      V F
Sbjct: 910  ISGEVSILDSTTIEITELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYKEYHTDTTVKF 969

Query: 846  KVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRL 905
             V + +E++A  E    L K F L   ++ ++M LFD  G +KKY +P+ IL+EF  LRL
Sbjct: 970  VVKMSEEKLAEAEA-VGLHKVFKLQTNLTCNSMVLFDHVGFLKKYESPQDILKEFFELRL 1028

Query: 906  KYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPH 964
            +YY  RK++L+         L  + +FI   ++ K    N+  + LI++L ++G  ++P 
Sbjct: 1029 RYYGLRKEWLIGMLGAESAKLNNQARFILEKIDGKIVIENKPKKELIQVLIQRGYESDP- 1087

Query: 965  VAGAIDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEK 1024
            V    +  +KE+E G+ ES  +S +   AT  D+ YL ++P    T E   +L  + D K
Sbjct: 1088 VKAWKELQNKEEEEGD-ESGEESAA---ATGPDFNYLLNMPLWYLTKEKKDELCKQRDNK 1143

Query: 1025 ENELKTLEHTSPDLMWLNDLELFEKEFD 1052
            + EL+ L+H SP  +W  DL  F +E D
Sbjct: 1144 DKELEDLKHKSPSDLWKEDLAAFVEELD 1171


  Database: uniref100
    Posted date:  Jan 5, 2005  1:24 AM
  Number of letters in database: 848,049,833
  Number of sequences in database:  2,790,947
  
Lambda     K      H
   0.323    0.139    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,723,804,566
Number of Sequences: 2790947
Number of extensions: 73689616
Number of successful extensions: 213593
Number of sequences better than 10.0: 3461
Number of HSP's better than 10.0 without gapping: 1054
Number of HSP's successfully gapped in prelim test: 2409
Number of HSP's that attempted gapping in prelim test: 207206
Number of HSP's gapped (non-prelim): 4399
length of query: 1053
length of database: 848,049,833
effective HSP length: 138
effective length of query: 915
effective length of database: 462,899,147
effective search space: 423552719505
effective search space used: 423552719505
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 80 (35.4 bits)