BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC136287.1 + phase: 1 /partial
         (436 letters)

Database: uniref100 
           2,790,947 sequences; 848,049,833 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

UniRef100_O80585 Methylenetetrahydrofolate reductase [Arabidopsi...   739  0.0
UniRef100_Q75HE6 Putative methylenetetrahydrofolate reductase [O...   732  0.0
UniRef100_Q9SE60 Methylenetetrahydrofolate reductase MTHFR1 [Ara...   727  0.0
UniRef100_Q9SE94 Methylenetetrahydrofolate reductase [Zea mays]       716  0.0
UniRef100_UPI0000248D41 UPI0000248D41 UniRef100 entry                 415  e-114
UniRef100_Q7ZWU2 Mthfr-prov protein [Xenopus laevis]                  408  e-112
UniRef100_UPI00002B2D5C UPI00002B2D5C UniRef100 entry                 403  e-111
UniRef100_UPI0000367E56 5,10-methylenetetrahydrofolate reductase...   398  e-109
UniRef100_Q5SNW6 5,10-methylenetetrahydrofolate reductase [Homo ...   398  e-109
UniRef100_P42898 Methylenetetrahydrofolate reductase [Homo sapiens]   398  e-109
UniRef100_Q60HE5 5,10-methylenetetrahydrofolate reductase [Macac...   394  e-108
UniRef100_UPI00003C2190 UPI00003C2190 UniRef100 entry                 390  e-107
UniRef100_UPI00001CF8BA UPI00001CF8BA UniRef100 entry                 386  e-106
UniRef100_UPI0000293287 UPI0000293287 UniRef100 entry                 385  e-105
UniRef100_Q8CDE4 Mus musculus adult male testis cDNA, RIKEN full...   383  e-105
UniRef100_Q9WU20 Methylenetetrahydrofolate reductase [Mus musculus]   383  e-105
UniRef100_UPI000024AD4A UPI000024AD4A UniRef100 entry                 381  e-104
UniRef100_UPI000042F086 UPI000042F086 UniRef100 entry                 372  e-101
UniRef100_UPI000023482A UPI000023482A UniRef100 entry                 363  5e-99
UniRef100_Q6CG63 Similar to sp|P53128 Saccharomyces cerevisiae M...   362  1e-98

>UniRef100_O80585 Methylenetetrahydrofolate reductase [Arabidopsis thaliana]
          Length = 594

 Score =  739 bits (1907), Expect = 0.0
 Identities = 346/433 (79%), Positives = 388/433 (88%)

Query: 1   AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
           AHPDVIG +GLA+ E YQSDL YLK K+DAGADLIVTQLFYDTDIFLKFVNDCRQIGI+C
Sbjct: 156 AHPDVIGENGLASNEAYQSDLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISC 215

Query: 61  PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
           PIVPGIMPINNY+GF+RMTGFCKTKIP E+MAALEPIKDNEEAVKAYGIHLGTEMCKK++
Sbjct: 216 PIVPGIMPINNYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKML 275

Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
           AHG+K++HLYTLNMEKSALAIL +LG+I+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335

Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
           PKSYISRT GWE +P GRW DS + SYGAL+D+QF RPRA+DKKL +EW VPLKS+EDI 
Sbjct: 336 PKSYISRTKGWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQ 395

Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
           E+F+  CLG L+++PWSELDGLQPET+IINE L K+N+KGFLTINSQP+VN E+SDSP V
Sbjct: 396 EKFKELCLGNLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTV 455

Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
           GWGGP GY+YQKAYLEFFCSKEKLDA++EK K  P +TYMAVNK   W SN  Q DVNAV
Sbjct: 456 GWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAV 515

Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
           TWGVFPAKEIIQPTIVDP SFNVWKDEAFE WSR WA+LYPEAD SR L+EEV +SY+LV
Sbjct: 516 TWGVFPAKEIIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLV 575

Query: 421 SLVDNDYANGDLF 433
           SLV+NDY NGD+F
Sbjct: 576 SLVENDYINGDIF 588


>UniRef100_Q75HE6 Putative methylenetetrahydrofolate reductase [Oryza sativa]
          Length = 594

 Score =  732 bits (1890), Expect = 0.0
 Identities = 352/433 (81%), Positives = 383/433 (88%)

Query: 1   AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
           AHPD I +   AT E Y +DLAYLK KVDAGADLI+TQLFYDTDIFLKFVNDCRQIGITC
Sbjct: 156 AHPDAIQSTEGATPEAYSNDLAYLKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITC 215

Query: 61  PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
           PIVPGIMPINNYKGF+RMTGFCKTKIPAEI AALEPIKDNEEAVKAYGIHLGTEMCKKI+
Sbjct: 216 PIVPGIMPINNYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKIL 275

Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
           A GIKT+HLYTLNMEKSAL IL +LGLIEESKISRSLPWR PTNVFRVKEDVRPIFWANR
Sbjct: 276 ATGIKTLHLYTLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANR 335

Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
           PKSYISRT+GW+QYPHGRW DS NPSYGALTDYQF RPR + KKL EEWAVP+KS+EDI 
Sbjct: 336 PKSYISRTLGWDQYPHGRWGDSRNPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDIN 395

Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
           ERF  FC GKL ++PWSELDGLQPETKII++ L KIN KGFLTINSQPAVNGE+SDS  V
Sbjct: 396 ERFMNFCQGKLTSSPWSELDGLQPETKIIDDQLVKINQKGFLTINSQPAVNGERSDSTSV 455

Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
           GWGGPGGY+YQKAYLEFFCSKEKLD LIEKSK  P LTY+AVNK+G   SN+    VNAV
Sbjct: 456 GWGGPGGYVYQKAYLEFFCSKEKLDQLIEKSKAFPSLTYIAVNKDGESFSNIPTNAVNAV 515

Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
           TWGVFP KEI+QPT+VD  SF VWKDEAFEIWS+GWA L+PE D+SR+++++V  SYFLV
Sbjct: 516 TWGVFPGKEIVQPTVVDSASFMVWKDEAFEIWSKGWACLFPEGDSSREILDKVQKSYFLV 575

Query: 421 SLVDNDYANGDLF 433
           SLVDNDY NGDLF
Sbjct: 576 SLVDNDYINGDLF 588


>UniRef100_Q9SE60 Methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis thaliana]
          Length = 592

 Score =  727 bits (1876), Expect = 0.0
 Identities = 339/433 (78%), Positives = 381/433 (87%)

Query: 1   AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
           AHPDVI ADGLAT E YQSDLAYLK KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGI C
Sbjct: 156 AHPDVIEADGLATPESYQSDLAYLKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINC 215

Query: 61  PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
           PIVPGIMPI+NYKGF+RM GFCKTKIPAE+ AALEPIKDN+EAVKAYGIH  TEMCKKI+
Sbjct: 216 PIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKIL 275

Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
           AHGI ++HLYTLN++KSA+ IL +LGLI+ESKISRSLPWRRP NVFR KEDVRPIFWANR
Sbjct: 276 AHGITSLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANR 335

Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
           PKSYISRT GW  +PHGRW DS + +Y  L+DYQF RP+ +DKKL +EW VPLKSIED+ 
Sbjct: 336 PKSYISRTKGWNDFPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQ 395

Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
           E+F+  C+G L+++PWSELDGLQPETKIINE L KIN+ GFLTINSQP+VN  KSDSP +
Sbjct: 396 EKFKELCIGNLKSSPWSELDGLQPETKIINEQLGKINSNGFLTINSQPSVNAAKSDSPAI 455

Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
           GWGGPGGY+YQKAYLEFFCSK+KLD L+EKSK  P +TYMAVNK   W SN G++DVNAV
Sbjct: 456 GWGGPGGYVYQKAYLEFFCSKDKLDTLVEKSKAFPSITYMAVNKSENWVSNTGESDVNAV 515

Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
           TWGVFPAKE+IQPTIVDP SF VWKDEAFEIWSR WA+LYPE D SRKL+EEV +SY+LV
Sbjct: 516 TWGVFPAKEVIQPTIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLV 575

Query: 421 SLVDNDYANGDLF 433
           SLVDN+Y NGD+F
Sbjct: 576 SLVDNNYINGDIF 588


>UniRef100_Q9SE94 Methylenetetrahydrofolate reductase [Zea mays]
          Length = 593

 Score =  716 bits (1848), Expect = 0.0
 Identities = 340/433 (78%), Positives = 377/433 (86%)

Query: 1   AHPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 60
           AHPD I  +G AT E Y +DLAYLK KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC
Sbjct: 156 AHPDAIQGEGGATLEAYSNDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITC 215

Query: 61  PIVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIM 120
           PIVPGIMPINNYKGF+RMTGFCKTKIP+EI AAL+PIKDNEEAV+ YGIHLGTEMCKKI+
Sbjct: 216 PIVPGIMPINNYKGFLRMTGFCKTKIPSEITAALDPIKDNEEAVRQYGIHLGTEMCKKIL 275

Query: 121 AHGIKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANR 180
           A GIKT+HLYTLNM+KSA+ IL +LGLIEESK+SR LPWR  TNVFRVKEDVRPIFWANR
Sbjct: 276 ATGIKTLHLYTLNMDKSAIGILMNLGLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANR 335

Query: 181 PKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIY 240
           PKSY+ RT+GW+QYPHGRW DS NPSYGALTD+QF RPR + KKL EEWAVPLKS+EDI 
Sbjct: 336 PKSYLKRTLGWDQYPHGRWGDSRNPSYGALTDHQFTRPRGRGKKLQEEWAVPLKSVEDIS 395

Query: 241 ERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIV 300
           ERF  FC GKL ++PWSELDGLQPETKII++ L  IN KGFLTINSQPAVNGEKSDSP V
Sbjct: 396 ERFTNFCQGKLTSSPWSELDGLQPETKIIDDQLVNINQKGFLTINSQPAVNGEKSDSPTV 455

Query: 301 GWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAV 360
           GWGGPGGY+YQKAYLEFFC+KEKLD LIEK K  P LTY+AVNK+G   SN+    VNAV
Sbjct: 456 GWGGPGGYVYQKAYLEFFCAKEKLDQLIEKIKAFPSLTYIAVNKDGETFSNISPNAVNAV 515

Query: 361 TWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLV 420
           TWGVFP KEIIQPT+VD  SF VWKDEAFEIW+RGW  ++PE D+SR+L+E+V  +Y+LV
Sbjct: 516 TWGVFPGKEIIQPTVVDHASFMVWKDEAFEIWTRGWGCMFPEGDSSRELLEKVQKTYYLV 575

Query: 421 SLVDNDYANGDLF 433
           SLVDNDY  GDLF
Sbjct: 576 SLVDNDYVQGDLF 588


>UniRef100_UPI0000248D41 UPI0000248D41 UniRef100 entry
          Length = 580

 Score =  415 bits (1066), Expect = e-114
 Identities = 208/438 (47%), Positives = 278/438 (62%), Gaps = 14/438 (3%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE Y+ DL +LK KVDAGA  IVTQLF+  + FLKFV DCR IGITCPI+PGI PI
Sbjct: 126 GHPEAESYEDDLRHLKEKVDAGAHFIVTQLFFRAETFLKFVKDCRAIGITCPILPGIFPI 185

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EI   +EPIKDN+ A++ YGI    EMCK ++A G +  +H
Sbjct: 186 QGYHSLRQLVKLSKLEVPEEIKQVIEPIKDNDAAIRNYGIQQAVEMCKVLLASGEVSGLH 245

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E + + +L  LGL  E    R  PW    +  R  EDVRPIFWA+RPKSYI RT
Sbjct: 246 FYTLNREVATMEVLRQLGLWAED--PRRPPWAISAHPKRKVEDVRPIFWASRPKSYIYRT 303

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+ +P+GRW +S +P++G LTDY   +++ ++  + L++ W   L S E +YE F  +
Sbjct: 304 QDWDDFPNGRWGNSSSPAFGELTDYYLFYLKSKSPKEALLQMWGEELMSEESVYEVFTNY 363

Query: 247 CLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G       K+   PW++ D L PET ++ + LEK+N +G LTINSQP +NG+ S   I
Sbjct: 364 ITGQTNRSGHKVMCLPWND-DPLAPETNLLKDELEKVNRRGVLTINSQPNINGKASSDAI 422

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIE-KSKDRPFLTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S E + AL++   K  P + Y  VN +G   +N      N
Sbjct: 423 VGWGPAGGYVFQKAYLEFFTSSENVTALLQVLKKYEPRVNYQIVNVQGRNITNAHDMQPN 482

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDPVSF  WKDEAF +W   WA LY +   SR +++ +  +YF
Sbjct: 483 AVTWGIFPGREIIQPTVVDPVSFMYWKDEAFALWIEQWAKLYEDESPSRMIIQYIHDNYF 542

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDND+   +  W V
Sbjct: 543 LVNLVDNDFPLDNCLWQV 560


>UniRef100_Q7ZWU2 Mthfr-prov protein [Xenopus laevis]
          Length = 643

 Score =  408 bits (1049), Expect = e-112
 Identities = 201/438 (45%), Positives = 280/438 (63%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE Y  DL +LK K+DAGAD I+TQLF+ ++ FL F+ DCR IGITCP++PGI PI
Sbjct: 194 GHPDAESYDQDLKHLKEKIDAGADFIITQLFFRSETFLTFLKDCRAIGITCPVLPGIFPI 253

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EIM  +EPIKDN+ A++ YGI L   MC++++  G +  +H
Sbjct: 254 QGYGSLRQLVKLSKLEVPQEIMDVIEPIKDNDAAIRNYGIDLAVSMCRELLDSGLVHGLH 313

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E + + +L  LG+ +E    R +PW    +  R  EDVRPIFWA+RPKSYI RT
Sbjct: 314 FYTLNREVATIDVLKRLGMWKEDP-RRPMPWAMSAHPKRRVEDVRPIFWASRPKSYIHRT 372

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F  +
Sbjct: 373 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGQELNSEESVFEVFTYY 432

Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G+   N       PW++ D L PET ++   L+K+N +G LTINSQP VNG+ S  PI
Sbjct: 433 ISGEPNPNGHKVNCLPWND-DPLAPETNLLKNELQKVNKRGILTINSQPNVNGKPSTDPI 491

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKD-RPFLTYMAVNKEGIWKSNVGQTDVN 358
           VGWG   GY++QKAYLEFF S E + ALI+  K   P + Y  VN  G   +N      N
Sbjct: 492 VGWGPSRGYVFQKAYLEFFTSSEMVSALIKVLKRYEPRVNYHIVNVHGQNITNAADLQPN 551

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDPVSF  WKDEAF +W   WA LY E   SR +++ +  +Y+
Sbjct: 552 AVTWGIFPGREIIQPTVVDPVSFVYWKDEAFALWIEQWAKLYEEESPSRMIIQYIHDNYY 611

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDND+   +  W V
Sbjct: 612 LVNLVDNDFPLENCLWQV 629


>UniRef100_UPI00002B2D5C UPI00002B2D5C UniRef100 entry
          Length = 538

 Score =  403 bits (1035), Expect = e-111
 Identities = 201/418 (48%), Positives = 270/418 (64%), Gaps = 7/418 (1%)

Query: 20  DLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMT 79
           D+ YLK KVDAG D++VTQLFYD D FL F + C   GI  PI+PGIMPI+NY  F + T
Sbjct: 116 DIQYLKEKVDAGVDMVVTQLFYDIDKFLTFRDKCISNGIDVPIIPGIMPIHNYARFKKFT 175

Query: 80  GFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHGIKTVHLYTLNMEKSAL 139
            FC  KIP  I+  +EPIK+++ +V  YGI  G  MC+K++  G+  +H YTLN+E S  
Sbjct: 176 QFCNVKIPNSIIKKIEPIKNDDSSVINYGIEQGATMCEKLIKEGVPGLHFYTLNLEHSVK 235

Query: 140 AILTSLGLIEESKISRSLPWRRPTNVFRVK-EDVRPIFWANRPKSYISRTIGWEQYPHGR 198
            IL S+GL+ + K +R LPWR+ ++  R   EDVRPIFW+NRP SY++RT  W+ +P+GR
Sbjct: 236 EILNSIGLVSDEKANRDLPWRQSSDQNRKSAEDVRPIFWSNRPISYLTRTENWDDFPNGR 295

Query: 199 WSDSGNPSYGALTDYQFMRPRAK----DKKLIEEWAVPLKSIEDIYERFRLFCLGKLRTN 254
           W D  +P++G L  Y  +R  +K     KK    W  P KSI+DI   F  FC G + + 
Sbjct: 296 WGDISSPTFGELNQYHAIRAGSKINEIRKKRKRIWGEP-KSIKDISNVFVSFCKGDINSL 354

Query: 255 PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIVGWGGPGGYIYQKAY 314
           PW E   L  E++ I++ L  +N  G  TINSQP VNG  S  P  GWG   G +YQKAY
Sbjct: 355 PWCETK-LAIESEHISKELVTLNKAGCFTINSQPNVNGISSADPNFGWGSEDGMVYQKAY 413

Query: 315 LEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAVTWGVFPAKEIIQPT 374
           LEFF SK  LDA++EK K    ++Y AVNK G   SNV + +VN VTWGVFP ++I QPT
Sbjct: 414 LEFFTSKNNLDAILEKIKSNKNISYQAVNKSGDIISNVKRDNVNVVTWGVFPGEKIKQPT 473

Query: 375 IVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLVSLVDNDYANGDL 432
           IVD +SF +WKDEAF +W   WA +Y +   S  ++  +  +YFLV++VDND+ + ++
Sbjct: 474 IVDAMSFMIWKDEAFSLWINDWAFIYEKDSISYSIINNIYENYFLVNIVDNDFISSNM 531


>UniRef100_UPI0000367E56 5,10-methylenetetrahydrofolate reductase [Homo sapiens]
          Length = 656

 Score =  398 bits (1023), Expect = e-109
 Identities = 196/438 (44%), Positives = 279/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   A  +++DL +LK KV AGAD I+TQLF++ D F +FV  C  +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EI   +EPIKDN+ A++ YGI L   +C++++A G +  +H
Sbjct: 260 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 319

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E +   +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLY 438

Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G+   N       PW++ + L  ET ++ E L ++N +G LTINSQP +NG+ S  PI
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 497

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E  +AL++  K     + Y  VN +G   +N  +   N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDPVSF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 617

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDND+   +  W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635


>UniRef100_Q5SNW6 5,10-methylenetetrahydrofolate reductase [Homo sapiens]
          Length = 697

 Score =  398 bits (1023), Expect = e-109
 Identities = 196/438 (44%), Positives = 279/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   A  +++DL +LK KV AGAD I+TQLF++ D F +FV  C  +GITCPIVPGI PI
Sbjct: 241 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 300

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EI   +EPIKDN+ A++ YGI L   +C++++A G +  +H
Sbjct: 301 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 360

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E +   +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 361 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 419

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F L+
Sbjct: 420 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLY 479

Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G+   N       PW++ + L  ET ++ E L ++N +G LTINSQP +NG+ S  PI
Sbjct: 480 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 538

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E  +AL++  K     + Y  VN +G   +N  +   N
Sbjct: 539 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 598

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDPVSF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 599 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 658

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDND+   +  W V
Sbjct: 659 LVNLVDNDFPLDNCLWQV 676


>UniRef100_P42898 Methylenetetrahydrofolate reductase [Homo sapiens]
          Length = 656

 Score =  398 bits (1023), Expect = e-109
 Identities = 196/438 (44%), Positives = 279/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   A  +++DL +LK KV AGAD I+TQLF++ D F +FV  C  +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EI   +EPIKDN+ A++ YGI L   +C++++A G +  +H
Sbjct: 260 QGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLH 319

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E +   +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLY 438

Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G+   N       PW++ + L  ET ++ E L ++N +G LTINSQP +NG+ S  PI
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPI 497

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E  +AL++  K     + Y  VN +G   +N  +   N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDPVSF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYF 617

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDND+   +  W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635


>UniRef100_Q60HE5 5,10-methylenetetrahydrofolate reductase [Macaca fascicularis]
          Length = 656

 Score =  394 bits (1012), Expect = e-108
 Identities = 194/438 (44%), Positives = 277/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   A  +++DL +LK KV AGAD I+TQLF++ D F +FV  C  +GITCPIVPGI PI
Sbjct: 200 GHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPI 259

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EI   +EPIKDN+ A++ YGI L   +C +++A G +  +H
Sbjct: 260 QGYHSLRQLVKQSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLH 319

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E +   +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 320 FYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 378

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  + L++ W   L S E ++E F L+
Sbjct: 379 QEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPRELLLKMWGEELTSEESVFEVFVLY 438

Query: 247 CLGKLRTN-------PWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G+   N       PW++ + L  ET ++ E L ++N +G LTINSQP +NG+ S  P+
Sbjct: 439 LSGEPNRNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPV 497

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E  +AL++  K     + Y  VN +G   +N  +   N
Sbjct: 498 VGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPN 557

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDP+SF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 558 AVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRTIIQYIHDNYF 617

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDND+   +  W V
Sbjct: 618 LVNLVDNDFPLDNCLWQV 635


>UniRef100_UPI00003C2190 UPI00003C2190 UniRef100 entry
          Length = 650

 Score =  390 bits (1001), Expect = e-107
 Identities = 202/435 (46%), Positives = 278/435 (63%), Gaps = 15/435 (3%)

Query: 2   HPDVIGADGLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCP 61
           HP+ I        +G + +L  LK K++AGAD I TQ+FYD DIF K+V D R  GI CP
Sbjct: 173 HPEAI--------DGPELELERLKEKIEAGADFIFTQMFYDFDIFAKWVKDVRAAGINCP 224

Query: 62  IVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMA 121
           I+PG+MPI  Y GF R T    T +P     AL+P++D+++ V+  G  L  EMCKKI+ 
Sbjct: 225 IIPGVMPIQTYGGFQRATARFGTLVPQYFHDALDPVRDDDQKVREIGTRLVGEMCKKIVG 284

Query: 122 HG--IKTVHLYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWAN 179
            G  I  +H+YT+N+EK +  +L  LGL         LPW       R +E +RPIFWAN
Sbjct: 285 TGLGISGLHIYTMNLEKGSRMLLDYLGLTPSVNQVSPLPWTPSLTPKRREEKIRPIFWAN 344

Query: 180 RPKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDI 239
           R KSY++RT  W+++P+GRW D+ +P+YG +  Y  ++ R  +++  E W  P   ++D+
Sbjct: 345 RAKSYVNRTETWDEFPNGRWGDARSPAYGDVDAYG-VKLRYSNEEAKEMWGAPT-CLDDV 402

Query: 240 YERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
              F+ FC G+++  PWSE   +  ET +I++ L K+N  GFLTINSQPAV+G +SD  +
Sbjct: 403 KTLFQQFCAGQVKALPWSETP-VARETSVISDKLAKMNQLGFLTINSQPAVDGARSDDKV 461

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNA 359
            GWG   GY+YQKAYLEFF S E LDALI + +  P +TY AVN +G  ++N      NA
Sbjct: 462 HGWGPKNGYVYQKAYLEFFVSPEDLDALIARIEADPQITYHAVNSQGDMRTNTNSEAPNA 521

Query: 360 VTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFL 419
           VTWGVFP  EIIQPTIV+ +SF  WKDEA+EI  R WA +Y     SRK +E++ +SYFL
Sbjct: 522 VTWGVFPHCEIIQPTIVESISFLAWKDEAYEI-GRNWAKVYEPTSPSRKFLEDMFNSYFL 580

Query: 420 VSLVDNDY-ANGDLF 433
           V++V ND+ AN  +F
Sbjct: 581 VNVVHNDFKANDSIF 595


>UniRef100_UPI00001CF8BA UPI00001CF8BA UniRef100 entry
          Length = 654

 Score =  386 bits (992), Expect = e-106
 Identities = 187/438 (42%), Positives = 276/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE ++ DL +LK KV AGAD I+TQLF++   F  FV  C  IGI+CPI+PGI PI
Sbjct: 199 GHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASSFFSFVKACEDIGISCPILPGIFPI 258

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P  I   +EPIKDN+ A++ YGI L   +C++++  G +  +H
Sbjct: 259 QGYTSLRQLVKLSKLEVPQTIKDVIEPIKDNDAAIRNYGIELAVNLCRELLDSGLVPGLH 318

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E + + +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 319 FYTLNREVATMEVLKQLGMWTEDP-RRPLPWAVSAHPKRREEDVRPIFWASRPKSYIYRT 377

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
            GW+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F  +
Sbjct: 378 QGWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHY 437

Query: 247 CLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G       ++   PW++ + L  ET ++ E L ++N  G LTINSQP +NG+ S  P+
Sbjct: 438 LSGEPNRHGYRVTCLPWND-EPLAAETSLMKEELLRVNRLGILTINSQPNINGKPSSDPV 496

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E ++AL++  K     + Y  V+ +G   +N  +   N
Sbjct: 497 VGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGENITNAPELQPN 556

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EI+QPT+VDP+SF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 557 AVTWGIFPGREIVQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYF 616

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDN++   +  W V
Sbjct: 617 LVNLVDNEFLLDNCLWQV 634


>UniRef100_UPI0000293287 UPI0000293287 UniRef100 entry
          Length = 845

 Score =  385 bits (989), Expect = e-105
 Identities = 188/416 (45%), Positives = 268/416 (64%), Gaps = 15/416 (3%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE Y+ DL +LK KVDAGAD ++TQLF+  + FLKF+ DCR++GITCP++PGI PI
Sbjct: 204 GHPEAESYEQDLRHLKEKVDAGADFVITQLFFRAETFLKFLEDCRRVGITCPVLPGIFPI 263

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y+   ++    K ++P EI + +EPIKDN+ A++ YGI L  +MC+ ++  G +  +H
Sbjct: 264 QGYQSLRQLVKLSKLELPEEITSIIEPIKDNDAAIRNYGIQLAVQMCRVLLDSGKVPGLH 323

Query: 129 LYTLNMEKSALAILTSLGL-IEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISR 187
            YTLN E + + +L  LGL IE+ +  R LPW    +  R  EDVRPIFW++RPKSYI R
Sbjct: 324 FYTLNREVATMEVLRQLGLWIEDPR--RPLPWAVSAHPKRKVEDVRPIFWSSRPKSYIYR 381

Query: 188 TIGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRL 245
           T  W+ +P+GRW +S +P++G L DY   +++ ++  + L++ W   L S E ++E F  
Sbjct: 382 TQDWDDFPNGRWGNSSSPAFGELNDYYLFYLKSKSSKEALLQMWGEELLSEESVFEVFTC 441

Query: 246 FCLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSP 298
           +          K+   PW++ + L PET ++ + LEK+N +G LTINSQP +NG+ S  P
Sbjct: 442 YITAQTNRSGQKVLCLPWND-EPLAPETNLLKDELEKVNRRGVLTINSQPNINGKPSTDP 500

Query: 299 IVGWGGPGGYIYQKAYLEFFCSKEKLDALIE-KSKDRPFLTYMAVNKEGIWKSNVGQTDV 357
           IVGWG  GGY+YQKAYLEFF S E + AL++   K  P + Y  VN  G   +N      
Sbjct: 501 IVGWGPAGGYVYQKAYLEFFTSSENVTALLKVLKKYEPRVNYHIVNVHGRNLTNAPDMQP 560

Query: 358 NAVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEV 413
           NAVTWG+F  +EI+QPT+VDPVSF  WKDEAF +W   WA LY +   SR +++ +
Sbjct: 561 NAVTWGIFAGREIVQPTVVDPVSFMSWKDEAFALWIEQWAKLYEDESPSRMIIQYI 616


>UniRef100_Q8CDE4 Mus musculus adult male testis cDNA, RIKEN full-length enriched
           library, clone:4933415G03
           product:5,10-methylenetetrahydrofolate reductase, full
           insert sequence [Mus musculus]
          Length = 654

 Score =  383 bits (984), Expect = e-105
 Identities = 186/438 (42%), Positives = 275/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE ++ DL +LK KV AGAD I+TQLF++   F  FV  C +IGI+CPI+PGI PI
Sbjct: 199 GHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASTFFSFVKACTEIGISCPILPGIFPI 258

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P +I   +EPIKDN+ A++ YGI L   +C++++  G +  +H
Sbjct: 259 QGYTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVSLCRELLDSGLVPGLH 318

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E + + +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 319 FYTLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 377

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F  +
Sbjct: 378 QDWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHY 437

Query: 247 CLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G       ++   PW++ + L  ET ++ E L ++N  G LTINSQP +N + S  P+
Sbjct: 438 LSGEPNRHGYRVTCLPWND-EPLAAETSLMKEELLRVNRLGILTINSQPNINAKPSSDPV 496

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E ++AL++  K     + Y  V+ +G   +N  +   N
Sbjct: 497 VGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGENITNAPELQPN 556

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDP+SF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 557 AVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYF 616

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDN++      W V
Sbjct: 617 LVNLVDNEFPLDSCLWQV 634


>UniRef100_Q9WU20 Methylenetetrahydrofolate reductase [Mus musculus]
          Length = 654

 Score =  383 bits (984), Expect = e-105
 Identities = 186/438 (42%), Positives = 275/438 (62%), Gaps = 13/438 (2%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE ++ DL +LK KV AGAD I+TQLF++   F  FV  C +IGI+CPI+PGI PI
Sbjct: 199 GHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASTFFSFVKACTEIGISCPILPGIFPI 258

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P +I   +EPIKDN+ A++ YGI L   +C++++  G +  +H
Sbjct: 259 QGYTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVRLCRELLDSGLVPGLH 318

Query: 129 LYTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRT 188
            YTLN E + + +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT
Sbjct: 319 FYTLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRT 377

Query: 189 IGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYERFRLF 246
             W+++P+GRW +S +P++G L DY   +++ ++  ++L++ W   L S E ++E F  +
Sbjct: 378 QDWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHY 437

Query: 247 CLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
             G       ++   PW++ + L  ET ++ E L ++N  G LTINSQP +N + S  P+
Sbjct: 438 LSGEPNRHGYRVTCLPWND-EPLAAETSLMKEELLRVNRLGILTINSQPNINAKPSSDPV 496

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPF-LTYMAVNKEGIWKSNVGQTDVN 358
           VGWG  GGY++QKAYLEFF S+E ++AL++  K     + Y  V+ +G   +N  +   N
Sbjct: 497 VGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGENITNAPELQPN 556

Query: 359 AVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYF 418
           AVTWG+FP +EIIQPT+VDP+SF  WKDEAF +W   W  LY E   SR +++ +  +YF
Sbjct: 557 AVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYF 616

Query: 419 LVSLVDNDYANGDLFWCV 436
           LV+LVDN++      W V
Sbjct: 617 LVNLVDNEFPLDSCLWQV 634


>UniRef100_UPI000024AD4A UPI000024AD4A UniRef100 entry
          Length = 547

 Score =  381 bits (979), Expect = e-104
 Identities = 200/442 (45%), Positives = 267/442 (60%), Gaps = 35/442 (7%)

Query: 10  GLATAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPI 69
           G   AE Y+ DL +LK KVDAGA  IVTQLF+  + FLKFV DCR IGITCPI+PGI PI
Sbjct: 122 GHPEAESYEDDLRHLKEKVDAGAHFIVTQLFFRAETFLKFVKDCRAIGITCPILPGIFPI 181

Query: 70  NNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVH 128
             Y    ++    K ++P EI   +EPIKDN+ A++ YGI    EMCK ++A G +  +H
Sbjct: 182 QGYHSLRQLVKLSKLEVPEEIKQVIEPIKDNDAAIRNYGIQQAVEMCKVLLASGEVSGLH 241

Query: 129 LYTLNMEKSALAILTSLGLIEESK----ISRSL-PWRRPTNVFRVKEDVRPIFWANRPKS 183
            YTLN E + + +L  LGL  E      IS  L PW    +  R  EDVRPIFWA+RPKS
Sbjct: 242 FYTLNREVATMEVLRQLGLWAEDPRVVYISGDLWPWAISAHPKRKVEDVRPIFWASRPKS 301

Query: 184 YISRTIGWEQYPHGRWSDSGNPSYGALTDYQ--FMRPRAKDKKLIEEWAVPLKSIEDIYE 241
           YI RT  W+ +P+GRW +S +P++G LTDY   +++ ++  + L++ W   L S E +YE
Sbjct: 302 YIYRTQDWDDFPNGRWGNSSSPAFGELTDYYLFYLKSKSPKEALLQMWGEELMSEESVYE 361

Query: 242 RFRLFCLG-------KLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEK 294
            F  +  G       K+   PW++ D L PET ++ + LEK+N +G LTINSQP +NG+ 
Sbjct: 362 VFTNYITGQTNRSGHKVMCLPWND-DPLAPETNLLKDELEKVNRRGVLTINSQPNINGKA 420

Query: 295 SDSPIVGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQ 354
           S   IVGWG  GGY++QK     F        L+EK     F T   +       +N   
Sbjct: 421 SSDAIVGWGPAGGYVFQKVSKTLF--------LLEKC----FFTIQNI-------TNAHD 461

Query: 355 TDVNAVTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVG 414
              NAVTWG+FP +EIIQPT+VDPVSF  WKDEAF +W   WA LY +   SR +++ + 
Sbjct: 462 MQPNAVTWGIFPGREIIQPTVVDPVSFMYWKDEAFALWIEQWAKLYEDESPSRMIIQYIH 521

Query: 415 SSYFLVSLVDNDYANGDLFWCV 436
            +YFLV+LVDND+   +  W V
Sbjct: 522 DNYFLVNLVDNDFPLDNCLWQV 543


>UniRef100_UPI000042F086 UPI000042F086 UniRef100 entry
          Length = 617

 Score =  372 bits (954), Expect = e-101
 Identities = 198/425 (46%), Positives = 266/425 (62%), Gaps = 15/425 (3%)

Query: 13  TAEGYQSDLAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNY 72
           T EG   ++ +LK+KVDAGA+ I TQ+FYDT IF  +V   R+ GI  PI+PGIMPI N+
Sbjct: 163 TPEGRAQEMEWLKAKVDAGAEFIFTQMFYDTSIFFDWVKRVREAGINVPIIPGIMPIQNW 222

Query: 73  KGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAH---GIKTVHL 129
           + F +        +P+    AL P++ ++E V+  G  L  +MCK I+ +   GIK +H+
Sbjct: 223 EKFEKWVQRENIIVPSHFYEALNPVRGDDEKVRQVGTKLVADMCKTILDNKEAGIKGLHI 282

Query: 130 YTLNMEKSALAILTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTI 189
           YTLN+EK A  +L  LG     +    LPWR      R +E +RPIFWANR +SY+SRT 
Sbjct: 283 YTLNLEKGARMLLRELGFEGRREQIAPLPWRPSLTPSRREETIRPIFWANRTRSYLSRTA 342

Query: 190 GWEQYPHGRWSDSGNPSYGALTDYQF-MRPRAKDKKLIEEWAVPLKSIEDIYERFRLFCL 248
            W+++P+GRW DS +P+YG L  Y   +   A D   +  W  P  S  D++  F  FC 
Sbjct: 343 DWDEFPNGRWGDSRSPAYGDLDGYPVSIGITAPDAYNL--WGHPTTS-SDLHALFARFCR 399

Query: 249 GKLRTNPWSELDGLQP---ETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIVGWGGP 305
           G L   PWS     QP   ET +I E L K+N  G+LTINSQPAV+G +SD  + GWG P
Sbjct: 400 GDLAKLPWST----QPPASETSLIIEQLAKMNELGYLTINSQPAVDGVRSDDKVHGWGPP 455

Query: 306 GGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAVTWGVF 365
           GGY+YQKAYLEFF S + L  LI + +  P +TY AVNK+G  ++N      NAVTWGVF
Sbjct: 456 GGYVYQKAYLEFFVSPDLLSPLIRRIEKDPRITYYAVNKQGDLRTNTHSESPNAVTWGVF 515

Query: 366 PAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLVSLVDN 425
           P KEI+QPTIV+ VSF  WKDEAFE+  + WA LYP    SRKL+ +  ++ +LV++V N
Sbjct: 516 PGKEIVQPTIVEAVSFIAWKDEAFELGLQ-WAHLYPAESPSRKLITDTMNTSYLVNIVAN 574

Query: 426 DYANG 430
           D+ +G
Sbjct: 575 DFRDG 579


>UniRef100_UPI000023482A UPI000023482A UniRef100 entry
          Length = 627

 Score =  363 bits (932), Expect = 5e-99
 Identities = 193/435 (44%), Positives = 274/435 (62%), Gaps = 12/435 (2%)

Query: 6   IGADGLATAEGYQSD----LAYLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCP 61
           IG  G        SD    + +LK KVDAG+  IVTQ+FYDTD F+K+V  CR  GI  P
Sbjct: 148 IGVGGYPEGADDNSDVDQLIDHLKEKVDAGSSFIVTQMFYDTDNFIKWVEKCRAKGINVP 207

Query: 62  IVPGIMPINNYKGFIRMTGFCKTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMA 121
           I+PGIMPI  Y  FIR   + KT IP + + ALEP+K+++ AVK  G  L  +MC++++A
Sbjct: 208 IIPGIMPIQTYAAFIRRANWTKTHIPPDWLEALEPVKNDDAAVKQVGKRLIADMCRRLIA 267

Query: 122 HGIKTVHLYTLNMEKSALAILTSLGL--IEESKISRSLPWRRPTNVFRVKEDVRPIFWAN 179
            GIK +H YT+N+ +S   +L  L L    E+ I R LPWR    + R +EDVRPIFW N
Sbjct: 268 SGIKHLHFYTMNLAQSTQLVLEELELTPTAEAPIPRPLPWRPSLGLNRREEDVRPIFWRN 327

Query: 180 RPKSYISRTIGWEQYPHGRWSDSGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDI 239
           R  SYI+RT  W+++P+GRW+DS +P++G L  Y  +  +  +++ I+ W  P  S+ D+
Sbjct: 328 RNSSYIARTAIWDEFPNGRWTDSRSPAFGELELYG-VGLKGTNEQNIKLWGEP-NSLRDL 385

Query: 240 YERFRLFCLGKLRTNPWSELDGLQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPI 299
            E F  F  G L   PWS+   + PET  I + L ++N +GF TINSQPAVNG KS  P+
Sbjct: 386 AEVFVRFLEGNLDRLPWSD-SPITPETSAIKDALVELNRRGFFTINSQPAVNGVKSSHPV 444

Query: 300 VGWGGPGGYIYQKAYLEFFCSKEKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNA 359
            GWG   G++YQKAYLE       +D LI + +    LTY AV K+G  ++N  +   NA
Sbjct: 445 FGWGPKNGFVYQKAYLELLVPPYVIDELIARIEANEDLTYHAVTKKGELRTNT-RDSPNA 503

Query: 360 VTWGVFPAKEIIQPTIVDPVSFNVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFL 419
           +TWG+F  +E++QPTIV+ VSF  WKDEA+++    WA  +  +  +RKL++ +  S++L
Sbjct: 504 LTWGIFAGREVVQPTIVETVSFLAWKDEAYQL-GEDWAKCHEASSPTRKLLQGIMDSWYL 562

Query: 420 VSLVDNDYANG-DLF 433
           V++V+ND+ N  DLF
Sbjct: 563 VNIVNNDFHNTYDLF 577


>UniRef100_Q6CG63 Similar to sp|P53128 Saccharomyces cerevisiae
           Methylenetetrahydrofolate reductase 2 [Yarrowia
           lipolytica]
          Length = 583

 Score =  362 bits (929), Expect = 1e-98
 Identities = 178/406 (43%), Positives = 265/406 (64%), Gaps = 6/406 (1%)

Query: 23  YLKSKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFIRMTGFC 82
           +LK KVDAG   IVTQ+FYDTD FLK+V+ CR  GI  PI+PGIMPI+ Y  F+R   +C
Sbjct: 170 HLKEKVDAGGTFIVTQMFYDTDNFLKWVDKCRAKGINVPIIPGIMPISTYASFMRRANWC 229

Query: 83  KTKIPAEIMAALEPIKDNEEAVKAYGIHLGTEMCKKIMAHG-IKTVHLYTLNMEKSALAI 141
           + +IP + +  LEP+KD++  V+  G  L  +MC+K++  G IK +H YT+N+EK+ + +
Sbjct: 230 QIQIPQDFLDQLEPVKDDDMRVRELGTQLVADMCQKMLDSGKIKHLHFYTMNLEKATVMV 289

Query: 142 LTSLGLIEESKISRSLPWRRPTNVFRVKEDVRPIFWANRPKSYISRTIGWEQYPHGRWSD 201
           L  L L  +      LPWR    + R  E VRPIFW NR +SY++RT  W+++P+GRW D
Sbjct: 290 LERLNLPAQDSAVAPLPWRPSLALGRQDETVRPIFWKNRKQSYVARTQDWDEFPNGRWGD 349

Query: 202 SGNPSYGALTDYQFMRPRAKDKKLIEEWAVPLKSIEDIYERFRLFCLGKLRTNPWSELDG 261
           S +P++G L  Y  +  R   +K++E W  P K+++D+      +  GKL + PWS++  
Sbjct: 350 SRSPAFGELETYGVLL-RQSPQKVLELWGEP-KTVDDLKTLLVNYLNGKLASLPWSDVP- 406

Query: 262 LQPETKIINEHLEKINTKGFLTINSQPAVNGEKSDSPIVGWGGPGGYIYQKAYLEFFCSK 321
           +  E + I   + ++N +G LTINSQPAVNG KS  P+ GWG   GY+YQKAYLE   + 
Sbjct: 407 ISNEIETIKPQILELNNRGILTINSQPAVNGAKSTHPVHGWGPKNGYVYQKAYLELLVTP 466

Query: 322 EKLDALIEKSKDRPFLTYMAVNKEGIWKSNVGQTDVNAVTWGVFPAKEIIQPTIVDPVSF 381
           E  + L++K +++  +T+ AVNK G  ++N      NAVTWG++P KE+IQPTIV+ +SF
Sbjct: 467 EVAEKLVKKLENQSEITFYAVNKTGNLQTN-APGGPNAVTWGIYPGKEVIQPTIVEKISF 525

Query: 382 NVWKDEAFEIWSRGWASLYPEADASRKLVEEVGSSYFLVSLVDNDY 427
             WK+EAF + S  WA  YP    SRK ++++ ++++LV++V ND+
Sbjct: 526 LAWKEEAFRLGSE-WAKCYPAESESRKFLDDIFNNWYLVNIVHNDF 570


  Database: uniref100
    Posted date:  Jan 5, 2005  1:24 AM
  Number of letters in database: 848,049,833
  Number of sequences in database:  2,790,947
  
Lambda     K      H
   0.319    0.138    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 785,464,462
Number of Sequences: 2790947
Number of extensions: 34620095
Number of successful extensions: 72374
Number of sequences better than 10.0: 232
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 71900
Number of HSP's gapped (non-prelim): 253
length of query: 436
length of database: 848,049,833
effective HSP length: 130
effective length of query: 306
effective length of database: 485,226,723
effective search space: 148479377238
effective search space used: 148479377238
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 76 (33.9 bits)