BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC149574.1 - phase: 0 /pseudo
(619 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein... 408 e-113
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote... 402 e-111
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote... 402 e-111
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote... 400 e-111
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote... 399 e-111
MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote... 399 e-110
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote... 398 e-110
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1) 392 e-108
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote... 388 e-107
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote... 387 e-107
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,... 363 e-100
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s... 362 1e-99
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,... 361 4e-99
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,... 359 1e-98
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g... 351 4e-96
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g... 330 7e-90
PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1 315 3e-85
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote... 312 2e-84
MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprote... 307 6e-83
MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprote... 292 2e-78
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
(P-glycoprotein 3)
Length = 1278
Score = 408 bits (1048), Expect = e-113
Identities = 235/637 (36%), Positives = 362/637 (55%), Gaps = 23/637 (3%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
GRTT+++AHRLST++NAD+IA E G +VE G+H ELI +Y LV Q S L
Sbjct: 578 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKK-EGIYFRLVNMQTSGSQILS 636
Query: 63 QSSSLKNSAEISHAATIGGSF------HSDRSSIGHALADEPRSVVKPRH-------VSL 109
+ ++ S E + + +S + S+ + A + R V+ VS
Sbjct: 637 EEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETNELDANVPPVSF 696
Query: 110 IRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHEVK--KIAF 167
+++ + W Y V GTL A GAL P F++ +S +++ + D T + K +
Sbjct: 697 LKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSE-MIAIFGPGDDTVKQQKCNMFSL 755
Query: 168 LFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSSR 227
+F G + + + ++ +FG GE LT R+R + A+L+ ++ WFDD +N++ LS+R
Sbjct: 756 VFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTR 815
Query: 228 LETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGEKL 287
L TDA ++ R ++ QN + T ++I+FI W++TL++L+ P I I E
Sbjct: 816 LATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMK 875
Query: 288 FMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQI 347
+ G K A +A EA+ NIRTV + E K +Y ++L P + S ++ I
Sbjct: 876 MLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHI 935
Query: 348 AGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAPD 407
GI + ISQ F++ SY +GS L+ FK ++ F +++ A+A+G + APD
Sbjct: 936 YGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPD 995
Query: 408 LLKGNQMVSSIFDMIDRKSGIIHDVGEELM---TVEGMIELKRINFIYPSRPNVVIFKDF 464
K + +F + +R+ +I E M EG + + F YP+R NV + +
Sbjct: 996 YAKAKLSAAYLFSLFERQP-LIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGL 1054
Query: 465 NLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLV 524
+L V G++LALVG SG GKS+++ L+ RFYDP +G V++DG++ KK+N++ LR Q+G+V
Sbjct: 1055 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIV 1114
Query: 525 QQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLL 582
QEP LF SI KNI YG S+ E++ AAK A+ H FI LP+ Y T+ GD+G L
Sbjct: 1115 SQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQL 1174
Query: 583 SGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
SGGQKQR+AIARA++R P++LLLDEATSALD ESE+V
Sbjct: 1175 SGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKV 1211
Score = 303 bits (776), Expect = 9e-82
Identities = 174/460 (37%), Positives = 264/460 (56%), Gaps = 6/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ + A+ + G + A I+ + + R ++R AIL+ E+GWFD T
Sbjct: 109 EMTRYAYYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMGWFDIKGTT 168
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-I 279
L++RL D + + + D+ + Q + ++ FI W++TLV++A ++ +
Sbjct: 169 E--LNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAITAILGL 226
Query: 280 SGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSK 339
S + K+ + F AY KA +A EA+ IRTV AF + K ++ Y L K
Sbjct: 227 STAVWAKI-LSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKK 285
Query: 340 RSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMG 399
K+ A I GI+ I++SY LA WYGS L+ + + + M F +++ A ++G
Sbjct: 286 IGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVG 345
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
+ IFD+ID I + G + +++G +E ++F YPSR N
Sbjct: 346 QAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRAN 405
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
+ I K NL V SG+++ALVG+SG GKS+ + L+ R YDPT G + IDG+DI+ N++ L
Sbjct: 406 IKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCL 465
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R+ IG+V QEP LF+T+I +NI YG+ + E+ +A K A+A++FI LP+ + T GD
Sbjct: 466 REFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGD 525
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
RG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE
Sbjct: 526 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565
Score = 55.5 bits (132), Expect = 4e-07
Identities = 25/52 (48%), Positives = 38/52 (73%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V++ G V E G H++L++ +Y S+V Q
Sbjct: 1222 GRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQ-KGIYFSMVNIQ 1272
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein 3)
Length = 1281
Score = 402 bits (1033), Expect = e-111
Identities = 235/638 (36%), Positives = 360/638 (55%), Gaps = 25/638 (3%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
GRTT+++AHRLST++NAD+IA E G +VE G+H EL+ +Y LV Q S L
Sbjct: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQK-EGVYFKLVNMQTSGSQILS 639
Query: 63 QSSSLKNSAEISHAATI--GGSFHSDRSSIGHAL-------------ADEPRSVVKPRHV 107
Q ++ S E + G H R+S +L ADE + V P V
Sbjct: 640 QEFEVELSEEKAADGMTPNGWKSHIFRNSTKKSLKSSRAHHHRLDVDADELDANVPP--V 697
Query: 108 SLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHEVKKIAF 167
S +++ + W Y V GT+ A GAL P ++ +S +++ + D + K F
Sbjct: 698 SFLKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSE-MIAIFGPGDDAVKQQKCNLF 756
Query: 168 --LFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLS 225
+F G +++ + ++ +FG GE LT R+R + A+L+ ++ WFDD +N++ LS
Sbjct: 757 SLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALS 816
Query: 226 SRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGE 285
+RL TD ++ R ++ QN + T ++I+FI W++TL++L+ P I I E
Sbjct: 817 TRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVE 876
Query: 286 KLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRG 345
+ G KA A +A EA+ NIRTV + E K +Y ++L EP + S +
Sbjct: 877 MKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMA 936
Query: 346 QIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALA 405
I GI + ISQ F++ SY +G+ L+ F+ ++ F ++ A+A+G + A
Sbjct: 937 HIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFA 996
Query: 406 PDLLKGNQMVSSIFDMIDRKSGIIHDVGEELM--TVEGMIELKRINFIYPSRPNVVIFKD 463
PD K + +F + +R+ I GE L EG + + F YP+R N+ + +
Sbjct: 997 PDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQG 1056
Query: 464 FNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGL 523
+L V G++LALVG SG GKS+++ L+ RFYDP +G V++DG++ KK+N++ LR Q+G+
Sbjct: 1057 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGI 1116
Query: 524 VQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVL 581
V QEP LF SI +NI YG S+ E++ AAK A+ H FI LP+ Y T+ GD+G
Sbjct: 1117 VSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQ 1176
Query: 582 LSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AI RA++R P++LLLDEATSALD ESE+V
Sbjct: 1177 LSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKV 1214
Score = 303 bits (777), Expect = 7e-82
Identities = 173/460 (37%), Positives = 264/460 (56%), Gaps = 6/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ + A+ + G + A I+ + + R ++R AIL+ E+GWFD T
Sbjct: 112 EMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMGWFDIKGTT 171
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-I 279
L++RL D + + + D+ + Q V ++ FI W++TLV++A P++ +
Sbjct: 172 E--LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGL 229
Query: 280 SGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSK 339
S + K+ + F AY KA +A EA+ IRTV AF + K ++ Y L K
Sbjct: 230 SAAVWAKI-LSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKK 288
Query: 340 RSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMG 399
K+ A I GI+ I++SY LA WYGS L+ + + + M F +++ A ++G
Sbjct: 289 IGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVG 348
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
+ IFD+ID I + G + +++G ++ ++F YPSR N
Sbjct: 349 QAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRAN 408
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
+ I K NL V SG+++ALVG+SG GK++ + L+ R YDPT G + IDG+DI+ N++ L
Sbjct: 409 IKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYL 468
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R+ IG+V QEP LF+T+I +NI YG+ + E+ +A K A+A+ FI LP+ + T G+
Sbjct: 469 REIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGE 528
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
RG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE
Sbjct: 529 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 568
Score = 55.5 bits (132), Expect = 4e-07
Identities = 25/52 (48%), Positives = 38/52 (73%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V++ G V E G H++L++ +Y S+V Q
Sbjct: 1225 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ-KGIYFSMVNIQ 1275
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein 1)
(CD243 antigen)
Length = 1280
Score = 402 bits (1033), Expect = e-111
Identities = 234/638 (36%), Positives = 363/638 (56%), Gaps = 24/638 (3%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPS------ 56
GRTT+++AHRLST++NAD+IA + G +VE GNH+EL+ +Y LV Q +
Sbjct: 579 GRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKE-KGIYFKLVTMQTAGNEVEL 637
Query: 57 ---PDPSLGQSSSLKNSAEISHAATIGGSFHSDRSSIGHALADEPRSVVKPR------HV 107
D S + +L+ S+ S ++ I S R S+ + A + + K V
Sbjct: 638 ENAADESKSEIDALEMSSNDSRSSLIRK--RSTRRSVRGSQAQDRKLSTKEALDESIPPV 695
Query: 108 SLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYM--DWDSTCHEVKKI 165
S R+ + W Y V G A G L P FA+ S + + D ++
Sbjct: 696 SFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLF 755
Query: 166 AFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLS 225
+ LF I++ + ++ +FG GE LT R+R ++ ++L+ ++ WFDD +NT+ L+
Sbjct: 756 SLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALT 815
Query: 226 SRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGE 285
+RL DA +K + R ++ QN+ + T ++I+FI W++TL++LA P+I + E
Sbjct: 816 TRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVE 875
Query: 286 KLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRG 345
+ G K A +A EA+ N RTV + E+K +YA L P + S ++
Sbjct: 876 MKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKA 935
Query: 346 QIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALA 405
I GI + +Q ++ SY +G+ L+ +L SF+ ++ F ++ A+A+G+ + A
Sbjct: 936 HIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFA 995
Query: 406 PDLLKGNQMVSSIFDMIDRKSGIIHDVGEELM--TVEGMIELKRINFIYPSRPNVVIFKD 463
PD K + I +I++ I E LM T+EG + + F YP+RP++ + +
Sbjct: 996 PDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQG 1055
Query: 464 FNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGL 523
+L V G++LALVG SG GKS+++ L+ RFYDP +GKV++DGK+IK++N++ LR +G+
Sbjct: 1056 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGI 1115
Query: 524 VQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVL 581
V QEP LF SI +NI YG S+ E++ AAK A+ H FI +LP YSTK GD+G
Sbjct: 1116 VSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQ 1175
Query: 582 LSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AIARA++R P ILLLDEATSALD ESE+V
Sbjct: 1176 LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV 1213
Score = 306 bits (784), Expect = 1e-82
Identities = 189/525 (36%), Positives = 288/525 (54%), Gaps = 33/525 (6%)
Query: 122 YGVFGTLAAFTTGALMPLFAL------------GISHALVS------------YYMDWDS 157
Y V GTLAA GA +PL L G L+S ++M+ +
Sbjct: 50 YMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEE 109
Query: 158 TCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDT 217
++ + A+ + G + A I+ + + R ++R AI++ EIGWFD
Sbjct: 110 ---DMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDV- 165
Query: 218 RNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPL 277
+ L++RL D + + + D+ + Q++ T ++ F W++TLV+LA P+
Sbjct: 166 -HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPV 224
Query: 278 I-ISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVE 336
+ +S + K+ + F AY KA +A E ++ IRTV AF ++K ++ Y L E
Sbjct: 225 LGLSAAVWAKI-LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEE 283
Query: 337 PSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTAL 396
+ K+ A I G + I++SY LA WYG+ L+ S ++ F +++ A
Sbjct: 284 AKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAF 343
Query: 397 AMGETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPS 454
++G+ IF +ID K I G + ++G +E + ++F YPS
Sbjct: 344 SVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPS 403
Query: 455 RPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNL 514
R V I K NL V SG+++ALVG+SG GKS+ + L+ R YDPT G V +DG+DI+ +N+
Sbjct: 404 RKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 515 KSLRKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTK 574
+ LR+ IG+V QEP LFAT+I +NI YG+E + E+ +A K A+A++FI LP + T
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 575 AGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
G+RG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE V
Sbjct: 524 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 568
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/52 (48%), Positives = 37/52 (71%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V + G V E G H++L++ +Y S+V Q
Sbjct: 1224 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQ 1274
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein 2)
Length = 1276
Score = 400 bits (1027), Expect = e-111
Identities = 233/636 (36%), Positives = 360/636 (55%), Gaps = 23/636 (3%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
GRTT+++AHRLSTI+NAD+IA E G +VE G+H EL+ +Y LV Q + L
Sbjct: 578 GRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKK-EGIYFRLVNMQTAGSQILS 636
Query: 63 QSSSLKNSAE--ISHAATIGGSFHSDRSSIGHAL-----------ADEPRSVVKPRHVSL 109
+ ++ S E A G R+S +L +E + V P VS
Sbjct: 637 EEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNELDANVPP--VSF 694
Query: 110 IRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHEVK--KIAF 167
+++ + W Y V GT+ A GAL P F++ +S +++ + D + K +
Sbjct: 695 LKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSE-MIAIFGPGDDAVKQQKCNMFSL 753
Query: 168 LFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSSR 227
+F G +++ + ++ +FG GE LT R+R + A+L+ ++ WFDD +N++ LS+R
Sbjct: 754 VFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTR 813
Query: 228 LETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGEKL 287
L TDA ++ + ++ QN + T ++I+FI W++TL++L+ P I I E
Sbjct: 814 LATDAAQVQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMK 873
Query: 288 FMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQI 347
+ G K A +A EA+ NIRTV + E K +Y ++L P + S ++ I
Sbjct: 874 MLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHI 933
Query: 348 AGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAPD 407
GI + ISQ F++ SY +GS L+ FK ++ F +++ A+A+G + APD
Sbjct: 934 YGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPD 993
Query: 408 LLKGNQMVSSIFDMIDRKSGIIHDVGEELM--TVEGMIELKRINFIYPSRPNVVIFKDFN 465
K + +F + +R+ I GE L EG + + F YP+R NV + + +
Sbjct: 994 YAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLS 1053
Query: 466 LIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLVQ 525
L V G++LALVG SG GKS+++ L+ RFYDP +G V++DG++ KK+N++ LR Q+G+V
Sbjct: 1054 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVS 1113
Query: 526 QEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLS 583
QEP LF SI +NI YG E++ AAK A+ H FI LP+ Y+T+ GD+G LS
Sbjct: 1114 QEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLS 1173
Query: 584 GGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
GGQKQR+AIARA++R P++LLLDEATSALD ESE+V
Sbjct: 1174 GGQKQRIAIARALIRQPRVLLLDEATSALDTESEKV 1209
Score = 308 bits (790), Expect = 2e-83
Identities = 176/460 (38%), Positives = 264/460 (57%), Gaps = 6/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ + A+ + G + A I+ + + R ++R AIL+ E+GWFD T
Sbjct: 109 EMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQKFFHAILRQEMGWFDIKGTT 168
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-I 279
L++RL D + + + D+ + Q + ++ FI W++TLV++A P++ +
Sbjct: 169 E--LNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAISPILGL 226
Query: 280 SGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSK 339
S + K+ + F AY KA +A EA IRTV AF + K ++ Y L K
Sbjct: 227 STAVWAKI-LSTFSDKELAAYAKAGAVAEEAPGAIRTVIAFGGQNKELERYQKHLENAKK 285
Query: 340 RSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMG 399
K+ A I GI+ I++SY LA WYGS L+ + + + M F +++ A ++G
Sbjct: 286 IGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVG 345
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
+ IFD+ID I + G + ++G +E ++F YPSR N
Sbjct: 346 QAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDNIKGNLEFSDVHFSYPSRAN 405
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
+ I K NL V SG+++ALVG+SG GKS+ + L+ R YDPT GK+ IDG+DI+ N++ L
Sbjct: 406 IKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKISIDGQDIRNFNVRCL 465
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R+ IG+V QEP LF+T+I +NI YG+ + E+ +A K A+A++FI LP+ + T GD
Sbjct: 466 REIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGD 525
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
RG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE
Sbjct: 526 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565
Score = 56.6 bits (135), Expect = 2e-07
Identities = 26/52 (50%), Positives = 38/52 (73%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V+E G V E G H++L++ +Y S+V Q
Sbjct: 1220 GRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQ-KGIYFSMVNIQ 1270
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1276
Score = 399 bits (1026), Expect = e-111
Identities = 227/638 (35%), Positives = 362/638 (56%), Gaps = 25/638 (3%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP-----SP 57
GRTT+++AHRLST++NAD+IA +GG +VE GNH+EL+ +Y LV Q P
Sbjct: 578 GRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMRE-KGIYFKLVMTQTRGNEIEP 636
Query: 58 DPSLGQSSSLKNSAEISHAATIGGSFHSDRSSIGHALADEPRSVVKPRHV-------SLI 110
+ S S +++E++ + H D+ R + V S
Sbjct: 637 GNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSMKEAVDEDVPLVSFW 696
Query: 111 RLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHEVKK-----I 165
R+ ++ W Y + G L A G + P+FA+ S + + D D HE K+
Sbjct: 697 RILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDD---HETKRQNCNLF 753
Query: 166 AFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLS 225
+ F +++ Y + +FG GE LT RVR ++ ++L+ +I WFDD +N++ L+
Sbjct: 754 SLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLT 813
Query: 226 SRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGE 285
+RL +DA+ +K + R ++ QNV + T ++++ + W++TL+++ PLI+ G I E
Sbjct: 814 TRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIE 873
Query: 286 KLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRG 345
+ G K + +A EA+ N RT+ + E+K +YA L P + + K+
Sbjct: 874 MKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKA 933
Query: 346 QIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALA 405
+ GI + +Q ++ SY +G+ L+ ++L +F+++M F ++ A+A G T + A
Sbjct: 934 HVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFA 993
Query: 406 PDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVVIFKD 463
PD K S I +I++ I G + +EG ++ + F YP+RPN+ + +
Sbjct: 994 PDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQG 1053
Query: 464 FNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGL 523
+L V G++LALVG SG GKS+++ L+ RFYDP +G V +DGK+IK++N++ LR +G+
Sbjct: 1054 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGI 1113
Query: 524 VQQEPALFATSIYKNILYG--KEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVL 581
V QEP LF SI +NI YG S E++ AAK A+ H FI +LP+ Y+T+ GD+G
Sbjct: 1114 VSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQ 1173
Query: 582 LSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AIARA++R P ILLLDEATSALD ESE+V
Sbjct: 1174 LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV 1211
Score = 304 bits (778), Expect = 5e-82
Identities = 192/521 (36%), Positives = 284/521 (53%), Gaps = 29/521 (5%)
Query: 124 VFGTLAAFTTGALMPLFALGISHALVSY---------------------YMDWDSTCHEV 162
+ GTLAA G L+PL L + S+ + S E+
Sbjct: 51 ILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEM 110
Query: 163 KKIAFLFCG-AAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTS 221
A+ + G A V I AY I+ + + R ++R AI+ EIGWFD +
Sbjct: 111 AIYAYYYTGIGAGVLIVAY-IQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFD--VHDV 167
Query: 222 SMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-IS 280
L++RL D + + + D+ + Q++ + +I FI W++TLV+LA PLI +S
Sbjct: 168 GELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLS 227
Query: 281 GHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKR 340
+ K+ + F +AY KA +A E ++ IRTV AF ++K ++ Y L E
Sbjct: 228 SALWAKV-LTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNV 286
Query: 341 SFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGE 400
K+ A I GI+ +++SY LA WYG+ L+ S ++ F +++ ++G
Sbjct: 287 GIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGH 346
Query: 401 TLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNV 458
IF +ID + I G + ++ G +E K ++F YPSR V
Sbjct: 347 LAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEV 406
Query: 459 VIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLR 518
I K NL V SG+++ALVG+SG GKS+ + L+ R YDP G V IDG+DI+ +N++ LR
Sbjct: 407 QILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLR 466
Query: 519 KQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDR 578
+ IG+V QEP LFAT+I +NI YG+E+ + E+ +A K A+A++FI LP + T G+R
Sbjct: 467 EIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGER 526
Query: 579 GVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
G LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE V
Sbjct: 527 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 567
Score = 58.2 bits (139), Expect = 6e-08
Identities = 26/50 (52%), Positives = 38/50 (76%), Gaps = 1/50 (2%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQ 52
GRT +++AHRLSTI+NAD+I V+E G V E G H++L++ +Y S+VQ
Sbjct: 1222 GRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQ-KGIYFSMVQ 1270
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1276
Score = 399 bits (1024), Expect = e-110
Identities = 230/641 (35%), Positives = 363/641 (55%), Gaps = 30/641 (4%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDP--- 59
GRTT+++AHRLST++NAD+IA +GG +VE GNHEEL+ +Y LV Q + +
Sbjct: 576 GRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMRE-KGIYFKLVMTQTAGNEIEL 634
Query: 60 --SLGQSS--------SLKNSAEI-----SHAATIGGSFHSDRSSIGHALADEPRSVVKP 104
+G+S S K+SA S +I G DR DE V P
Sbjct: 635 GNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDED---VPP 691
Query: 105 RHVSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTC--HEV 162
+S R+ + W Y V G A GAL P F++ S + + + D H+
Sbjct: 692 --ISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDS 749
Query: 163 KKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSS 222
+ LF +++ + ++ +FG GE LT R+R ++ ++L+ ++ WFD+ +NT+
Sbjct: 750 NLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTG 809
Query: 223 MLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGH 282
L++RL DA +K R ++ QN+ + T ++I+ I W++TL++LA P+I
Sbjct: 810 ALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAG 869
Query: 283 IGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSF 342
+ E + G K + +A EA+ N RTV + E+K ++YA L P + +
Sbjct: 870 VVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNAL 929
Query: 343 KRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETL 402
K+ + GI + +Q ++ SY +G+ L+ +EL +F++++ F ++ A+A+G+
Sbjct: 930 KKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVS 989
Query: 403 ALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVVI 460
+ APD K S I +I++ I G + T+EG ++ + F YP+RP++ +
Sbjct: 990 SFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPV 1049
Query: 461 FKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQ 520
+ NL V G++LALVG SG GKS+++ L+ RFYDP +G V +DGK++ ++N++ LR
Sbjct: 1050 LQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAH 1109
Query: 521 IGLVQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDR 578
+G+V QEP LF SI +NI YG S+ E+ AAK A+ H FI +LP+ Y+T+ GD+
Sbjct: 1110 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDK 1169
Query: 579 GVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
G LSGGQKQR+AIARA++R P ILLLDEATSALD ESE+V
Sbjct: 1170 GTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV 1210
Score = 304 bits (779), Expect = 4e-82
Identities = 193/521 (37%), Positives = 286/521 (54%), Gaps = 27/521 (5%)
Query: 122 YGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCH-------------------EV 162
Y + GTLAA G +PL L S+ + + E+
Sbjct: 49 YMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNATQVNASDIFGKLEEEM 108
Query: 163 KKIAFLFCG-AAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTS 221
A+ + G A V I AY I+ + + R ++R AI+ EIGWFD +
Sbjct: 109 TTYAYYYTGIGAGVLIVAY-IQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFD--VHDV 165
Query: 222 SMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-IS 280
L++RL D + + + D+ + Q + +I F W++TLV+LA P++ +S
Sbjct: 166 GELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLS 225
Query: 281 GHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKR 340
I K+ + F +AY KA +A E ++ IRTV AF ++K ++ Y + L E +
Sbjct: 226 AGIWAKI-LSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRL 284
Query: 341 SFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGE 400
K+ A I G + I++SY LA WYG+ L+ + S ++ F +++ A ++G+
Sbjct: 285 GIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQ 344
Query: 401 TLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNV 458
IF++ID K I G + ++G +E K I+F YPSR +V
Sbjct: 345 ASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDV 404
Query: 459 VIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLR 518
I K NL V SG+++ALVG+SG GKS+ + L+ R YDPT G V IDG+DI+ +N++ LR
Sbjct: 405 QILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLR 464
Query: 519 KQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDR 578
+ IG+V QEP LFAT+I +NI YG+E + E+ +A K A+A++FI LP + T G+R
Sbjct: 465 EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGER 524
Query: 579 GVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
G LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE V
Sbjct: 525 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 565
Score = 55.8 bits (133), Expect = 3e-07
Identities = 25/52 (48%), Positives = 38/52 (73%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V++ G V E G H++L++ +Y S+V Q
Sbjct: 1221 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ-KGIYFSMVSVQ 1271
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein 3)
Length = 1279
Score = 398 bits (1022), Expect = e-110
Identities = 233/638 (36%), Positives = 359/638 (55%), Gaps = 27/638 (4%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
GRTT+++AHRLST++NAD+IA E G +VE G+H EL+ +Y LV Q S
Sbjct: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQTSGSQIQS 639
Query: 63 QSSSLKNSAEISHAATIGGSF----HSDRSSIGHAL---------ADEPRSVVKPRHVSL 109
+ L + + A G HS + ++ ++ D + V P VS
Sbjct: 640 EEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP--VSF 697
Query: 110 IRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHE---VKKIA 166
+++ + W Y V GT+ A G L P F++ S + + D+ + + +
Sbjct: 698 LKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLI 757
Query: 167 FLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSS 226
FLF G I++ + ++ +FG GE LT R+R + A+L+ ++ WFDD +N++ LS+
Sbjct: 758 FLFLG--IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALST 815
Query: 227 RLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGEK 286
RL TDA ++ R ++ QN+ + T ++I+FI W++TL++LA P+I I E
Sbjct: 816 RLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEM 875
Query: 287 LFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQ 346
+ G K A +A EA+ NIRTV + E K +Y ++L P + S ++
Sbjct: 876 KLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAH 935
Query: 347 IAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAP 406
I GI + ISQ F++ SY +G+ L+ F+ ++ F ++ A+A+G + AP
Sbjct: 936 IYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAP 995
Query: 407 DLLKGNQMVSSIFDMIDRKSGIIHDVGEELM---TVEGMIELKRINFIYPSRPNVVIFKD 463
D K + +F + +R+ +I EE + EG I + F YP+R NV + +
Sbjct: 996 DYAKAKLSAAHLFMLFERQP-LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1054
Query: 464 FNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGL 523
+L V G++LALVG SG GKS+++ L+ RFYDP +G V++DG++ KK+N++ LR Q+G+
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1114
Query: 524 VQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVL 581
V QEP LF SI +NI YG S+ E++ AAK A+ H FI LP Y T+ GD+G
Sbjct: 1115 VSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQ 1174
Query: 582 LSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AIARA++R P+ILLLDEATSALD ESE+V
Sbjct: 1175 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKV 1212
Score = 306 bits (784), Expect = 1e-82
Identities = 176/460 (38%), Positives = 263/460 (56%), Gaps = 6/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ + A+ + G + A I+ + + R ++R AIL+ EIGWFD N
Sbjct: 112 EMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDI--ND 169
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-I 279
++ L++RL D + + + D+ + Q V ++ FI W++TLV++A P++ +
Sbjct: 170 TTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGL 229
Query: 280 SGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSK 339
S + K+ + F AY KA +A EA+ IRTV AF + K ++ Y L +
Sbjct: 230 SAAVWAKI-LSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKE 288
Query: 340 RSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMG 399
K+ A I GI+ I++SY LA WYGS L+ + + + M F +++ A ++G
Sbjct: 289 IGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVG 348
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
+ IFD+ID I + G + +++G +E ++F YPSR N
Sbjct: 349 QAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRAN 408
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
V I K NL V SG+++ALVG SG GKS+ + LI R YDP G + IDG+DI+ N+ L
Sbjct: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYL 468
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R+ IG+V QEP LF+T+I +NI YG+ + E+ +A K A+A+ FI LP+ + T G+
Sbjct: 469 REIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGE 528
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
RG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE
Sbjct: 529 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 568
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/52 (48%), Positives = 37/52 (71%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V + G V E G H++L++ +Y S+V Q
Sbjct: 1223 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQ 1273
>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1277
Score = 392 bits (1008), Expect = e-108
Identities = 234/641 (36%), Positives = 365/641 (56%), Gaps = 30/641 (4%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP-----SP 57
GRTT+++AHRLST++NAD+IA +GG +VE GNHEEL+ +Y LV Q P
Sbjct: 578 GRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKE-KGIYFKLVMTQTRGNEIEP 636
Query: 58 DPSLGQSSSLKNSAEISHAATIGGSFH-SDRSSIGHALADEPRSVVKPRHV-------SL 109
+ +S S ++E++ + S R SI H D+ R + V S
Sbjct: 637 GNNAYESQSDTGASELTSEESKSPLIRRSIRRSI-HRRQDQERRLSSKEDVDEDVPMVSF 695
Query: 110 IRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHEVKK----- 164
++ + W Y V G L A G + P+FA+ S + + D D HE K+
Sbjct: 696 WQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDD---HETKQRNCNL 752
Query: 165 IAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSML 224
+ LF +++ Y + +FG GE LT R+R ++ ++L+ +I WFDD +NT+ L
Sbjct: 753 FSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSL 812
Query: 225 SSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFIL--NWRITLVVLATYPLIISGH 282
++RL +DA+ +K + R ++ QNV + T ++++ +L W++TL+++ PLI+ G
Sbjct: 813 TTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGG 872
Query: 283 IGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSF 342
I E + G K + +A EA+ N RTV + E+K +YA L P + +
Sbjct: 873 IIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAL 932
Query: 343 KRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETL 402
K+ + GI + +Q I+ SY +G+ L+ +EL +F+++M F ++ A+A G T
Sbjct: 933 KKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTS 992
Query: 403 ALAPDLLKGNQMVSSIFDMIDRKSGIIHDVGEELMT--VEGMIELKRINFIYPSRPNVVI 460
+ APD K S I +I++ I E L +EG ++ + F YP+RPN+ +
Sbjct: 993 SFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPV 1052
Query: 461 FKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQ 520
+ + V G++L LVG SG GKS+++ L+ RFY+P +G V +DGK+IK++N++ +R
Sbjct: 1053 LQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA- 1111
Query: 521 IGLVQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDR 578
+G+V QEP LF SI +NI YG S E++ AA+ A+ H FI +LPE Y+T+ GD+
Sbjct: 1112 LGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDK 1171
Query: 579 GVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
G LSGGQKQR+AIARA++R P ILLLDEATSALD ESE+V
Sbjct: 1172 GTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV 1212
Score = 306 bits (783), Expect = 1e-82
Identities = 193/520 (37%), Positives = 283/520 (54%), Gaps = 30/520 (5%)
Query: 126 GTLAAFTTGALMPLFALGISHALVSYYMDWD----------------------STCHEVK 163
GTLAA G L+PL L + S+ D S ++
Sbjct: 52 GTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITNQSEINSTHTVSDTSLEEDMA 111
Query: 164 KIAFLFCG-AAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSS 222
A+ + G A V I AY I+ + + R ++R AI+ EIGWFD N +
Sbjct: 112 MYAYYYTGIGAGVLIVAY-IQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDV--NDAG 168
Query: 223 MLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-ISG 281
L++RL D + + + D+ + Q++ +I FI W++TLV+LA PLI +S
Sbjct: 169 ELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSS 228
Query: 282 HIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRS 341
+ K+ + F +AY KA +A E ++ IRTV AF ++K ++ Y L E +
Sbjct: 229 AMWAKV-LTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVG 287
Query: 342 FKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGET 401
K+ A I GI+ +++SY LA WYG+ L+ S ++ F +++ ++G
Sbjct: 288 IKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHL 347
Query: 402 LALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVV 459
IF +ID + I G + ++ G +E K + F YPSR V
Sbjct: 348 APNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVK 407
Query: 460 IFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRK 519
I K NL V SG+++ALVG+SG GKS+ + L+ R YDP G+V IDG+DI+ +N++ LR+
Sbjct: 408 ILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLRE 467
Query: 520 QIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRG 579
IG+V QEP LFAT+I +NI YG+E + E+ +A K A+A++FI LP + T G+RG
Sbjct: 468 IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERG 527
Query: 580 VLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE V
Sbjct: 528 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 567
Score = 57.4 bits (137), Expect = 1e-07
Identities = 26/50 (52%), Positives = 38/50 (76%), Gaps = 1/50 (2%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQ 52
GRT V++AHRLSTI+NAD+I V++ G V E G H++L++ +Y S+VQ
Sbjct: 1223 GRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQ-KGIYFSMVQ 1271
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein 3)
(MDR1A)
Length = 1276
Score = 388 bits (997), Expect = e-107
Identities = 228/642 (35%), Positives = 358/642 (55%), Gaps = 32/642 (4%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDP--- 59
GRTT+++AHRLST++NAD+IA +GG +VE GNH+EL+ +Y LV Q + +
Sbjct: 575 GRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMRE-KGIYFKLVMTQTAGNEIEL 633
Query: 60 ------------SLGQSSSLKNSAEISHAAT---IGGSFHSDRSSIGHALADEPRSVVKP 104
+L SS S+ I +T I G DR DE V P
Sbjct: 634 GNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDED---VPP 690
Query: 105 RHVSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDW---DSTCHE 161
S R+ + W Y V G A G L P F++ I +V + + ++
Sbjct: 691 --ASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSV-IFSKVVGVFTNGGPPETQRQN 747
Query: 162 VKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTS 221
+ LF I++ + ++ +FG GE LT R+R ++ ++L+ ++ WFDD +NT+
Sbjct: 748 SNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTT 807
Query: 222 SMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISG 281
L++RL DA +K R ++ QN+ + T ++I+ I W++TL++LA P+I
Sbjct: 808 GALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIA 867
Query: 282 HIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRS 341
+ E + G K + +A EA+ N RTV + E+K +YA L P + +
Sbjct: 868 GVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNA 927
Query: 342 FKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGET 401
K+ + GI + +Q ++ SY +G+ L+ ++L +F++++ F ++ A+A+G+
Sbjct: 928 MKKAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQV 987
Query: 402 LALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVV 459
+ APD K S I +I++ I G + +EG ++ F YP+RP++
Sbjct: 988 SSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIP 1047
Query: 460 IFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRK 519
+ + +L V G++LALVG SG GKS+++ L+ RFYDP +G V +DGK+IK++N++ LR
Sbjct: 1048 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRA 1107
Query: 520 QIGLVQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
Q+G+V QEP LF SI +NI YG S E++ AAK A+ H FI +LP+ Y+T+ GD
Sbjct: 1108 QLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGD 1167
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
+G LSGGQKQR+AIARA++R P ILLLDEATSALD ESE+V
Sbjct: 1168 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV 1209
Score = 302 bits (773), Expect = 2e-81
Identities = 193/520 (37%), Positives = 285/520 (54%), Gaps = 26/520 (5%)
Query: 122 YGVFGTLAAFTTGALMPLFALGISHALVSY----YMDWDSTC--------------HEVK 163
Y + GTLAA G +PL L S+ + +ST E+
Sbjct: 49 YMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMT 108
Query: 164 KIAFLFCG-AAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSS 222
A+ + G A V I AY I+ + + R ++R AI+ EIGWFD +
Sbjct: 109 TYAYYYTGIGAGVLIVAY-IQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFD--VHDVG 165
Query: 223 MLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-ISG 281
L++RL D + + + D+ + Q + +I F W++TLV+LA P++ +S
Sbjct: 166 ELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSA 225
Query: 282 HIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRS 341
I K+ + F AY KA +A E ++ IRTV AF ++K ++ Y + L E +
Sbjct: 226 GIWAKI-LSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLG 284
Query: 342 FKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGET 401
K+ A I G + I++SY LA WYG+ L+ + S ++ F +++ A ++G+
Sbjct: 285 IKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQA 344
Query: 402 LALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVV 459
+F +ID K I G + ++G +E K I+F YPSR V
Sbjct: 345 SPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQ 404
Query: 460 IFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRK 519
I K NL V SG+++ALVG+SG GKS+ + L+ R YDP G V IDG+DI+ +N++ LR+
Sbjct: 405 ILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLRE 464
Query: 520 QIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRG 579
IG+V QEP LFAT+I +NI YG+E+ + E+ +A K A+A++FI LP + T G+RG
Sbjct: 465 IIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERG 524
Query: 580 VLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE V
Sbjct: 525 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 564
Score = 55.8 bits (133), Expect = 3e-07
Identities = 25/52 (48%), Positives = 38/52 (73%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLSTI+NAD+I V++ G V E G H++L++ +Y S+V Q
Sbjct: 1220 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ-KGIYFSMVSVQ 1270
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein 2)
Length = 1276
Score = 387 bits (993), Expect = e-107
Identities = 228/640 (35%), Positives = 355/640 (54%), Gaps = 29/640 (4%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
GRTT+++AHRLST++NAD+IA +GG +VE GNHEEL+ +Y LV Q + G
Sbjct: 578 GRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKE-KGIYCRLVMMQ-----TRG 631
Query: 63 QSSSLKNSAEISHAATIGGSFHSDR-----------SSIGHALADEPRSVVKPRHVSLIR 111
L + A+ S + TI S+ SI + E R VK +
Sbjct: 632 NEVELGSEADGSQSDTIASELTSEEFKSPSVRKSTCRSICGSQDQERRVSVKEAQDEDVP 691
Query: 112 LYSMIG------PYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHE--VK 163
L S G W Y V G L A G + P+F++ S + + D D +
Sbjct: 692 LVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFSGIIGVFTRDDDPKTKQQNCN 751
Query: 164 KIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSM 223
+ F ++ Y + +FG GE LT R+R ++ ++L+ +I WFDD RN++
Sbjct: 752 LFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGA 811
Query: 224 LSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHI 283
L++RL +DA +K + R + QNV + T ++I+ + W++TL+++ PLII +
Sbjct: 812 LTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISLVYGWQLTLLLVVIAPLIILSGM 871
Query: 284 GEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFK 343
E + G K + +A EA+ N RTV + E+K ++YA L P + + K
Sbjct: 872 MEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALK 931
Query: 344 RGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLA 403
+ + GI + +Q ++ SY +G+ L+ ++ +F+++M F ++ A+A G +
Sbjct: 932 KAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASS 991
Query: 404 LAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVVIF 461
APD K S I ++++ I G + +EG ++ + F YP+RP++ +
Sbjct: 992 FAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVL 1051
Query: 462 KDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQI 521
+ +L V G++LALVG SG GKS+++ L+ RFYDP +G V +DGK+IK++N++ LR +
Sbjct: 1052 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHL 1111
Query: 522 GLVQQEPALFATSIYKNILYGKEE--ASESEVIEAAKLADAHNFISALPEGYSTKAGDRG 579
G+V QEP LF SI +NI YG S+ E+ AAK A+ H FI +LP+ Y+T+ GD+G
Sbjct: 1112 GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKG 1171
Query: 580 VLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LSGGQKQR+AIARA++R P ILLLDEATSALD ESE+V
Sbjct: 1172 TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV 1211
Score = 305 bits (780), Expect = 3e-82
Identities = 193/522 (36%), Positives = 283/522 (53%), Gaps = 28/522 (5%)
Query: 122 YGVFGTLAAFTTGALMPLFALGISHALVSYYMD----WDSTCHE---------------- 161
Y V GTLAA G +PL L + S+ W + ++
Sbjct: 50 YMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIWPNMTNQSEINNTEVISGSLEED 109
Query: 162 VKKIAFLFCG-AAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
+ A+ + G A V I AY I+ + + R ++R AI+ EIGWFD +
Sbjct: 110 MATYAYYYTGIGAGVLIVAY-IQVSFWCLAAGRQINKIRQKFFHAIMNQEIGWFDV--HD 166
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLI-I 279
L++RL D + + + D+ + Q++ + A ++ FI W++TLV+LA PLI +
Sbjct: 167 IGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIVGFISGWKLTLVILAVSPLIGL 226
Query: 280 SGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSK 339
S + K+ + F +AY KA +A E ++ IRTV AF + K ++ Y L E
Sbjct: 227 SSAMWAKV-LTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQNKELERYNKNLEEAKN 285
Query: 340 RSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMG 399
K+ A I GI+ +++SY LA WYG+ L+ S ++ F ++ ++G
Sbjct: 286 VGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEYSVGQVLTVFFSILFGTFSIG 345
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
IF +ID + I G + +V G +E K ++F YPSR
Sbjct: 346 HIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPDSVMGNLEFKNVHFSYPSRSG 405
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
+ I K NL V SG+++ALVG SG GKS+ + L+ R YDPT G V IDG+DI+ +N++ L
Sbjct: 406 IKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYL 465
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R+ IG+V QEP LFAT+I +NI YG+E + E+ +A K A+A++FI LP + T G+
Sbjct: 466 REIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 525
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
RG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE V
Sbjct: 526 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 567
Score = 57.0 bits (136), Expect = 1e-07
Identities = 25/50 (50%), Positives = 38/50 (76%), Gaps = 1/50 (2%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQ 52
GRT +++AHRLSTI+NAD+I V++ G V E G H++L++ +Y S+VQ
Sbjct: 1222 GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ-KGIYFSMVQ 1270
>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 363 bits (933), Expect = e-100
Identities = 227/650 (34%), Positives = 341/650 (51%), Gaps = 35/650 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPN------SLYSSLVQGQPS 56
G T V VAHR +TI+ AD+I E G+ VE G EEL+ +L S QG
Sbjct: 607 GHTIVSVAHRPATIRTADVIIGCEHGAAVERGTEEELLERKGVYFALVTLQSQRNQGDQE 666
Query: 57 PDPSLGQSSSL--KNSAEISHAATIGGSFHSDRSSIGHALADEPRSVV---KPRH----- 106
+ + K + ++ ++ S S LA EP V K H
Sbjct: 667 ENEKDATEDDIPEKTFSRGNYQDSLRASLRQRSKSQLSYLAHEPPMAVEDHKSTHEEDRK 726
Query: 107 ------------VSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYM- 153
S+ R+ + P W Y + G++ A GA+ PL+A S L ++ +
Sbjct: 727 DKDLPAQEDIEPASVRRIMKLNAPEWPYMLLGSMGAAVNGAVTPLYAFLFSQILGTFSLP 786
Query: 154 DWDSTCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGW 213
D + ++ I LF V+ ++ +F GE LT R+R A+L +IGW
Sbjct: 787 DKEEQRSQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGW 846
Query: 214 FDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLA 273
FDD RN+ L++RL TDA+ ++ + +++ + V A++IAF+ +W++TL ++
Sbjct: 847 FDDLRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVC 906
Query: 274 TYP-LIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYAD 332
+P L +SG + K+ + GF +A KA + EA+SNIRTVA E K I+ +
Sbjct: 907 FFPFLALSGALQTKM-LTGFASRDKQALEKAGQITSEALSNIRTVAGIGKERKFIETFEA 965
Query: 333 ELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLI 392
EL +P K + K+ + G+ +G SQ F + + YG L+ E F + + ++
Sbjct: 966 ELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYGGYLISNEGLHFSYVFRVISAVV 1025
Query: 393 VTALAMGETLALAPDLLKGNQMVSSIFDMIDRKS--GIIHDVGEELMTVEGMIELKRINF 450
++A A+G + P K + F ++DR+ + GE+ +G I+ F
Sbjct: 1026 LSATALGRASSYTPSYAKAKISAARFFQLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKF 1085
Query: 451 IYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIK 510
YPSRP++ + ++ + ++LA VG SG GKS+ I L+ RFYDP GKVMIDG D +
Sbjct: 1086 TYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSR 1145
Query: 511 KMNLKSLRKQIGLVQQEPALFATSIYKNILYG--KEEASESEVIEAAKLADAHNFISALP 568
K+N++ LR IG+V QEP LFA SI NI YG +E +I AAK A H+F+ +LP
Sbjct: 1146 KVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERIIAAAKKAQVHDFVMSLP 1205
Query: 569 EGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESER 618
E Y T G +G LS G+KQR+AIARAI+R+PKILLLDEATSALD ESE+
Sbjct: 1206 EKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
Score = 298 bits (764), Expect = 2e-80
Identities = 178/460 (38%), Positives = 264/460 (56%), Gaps = 5/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ + A + G I +T I+ +GI ++R I++ IGW D N+
Sbjct: 137 EMIRFAGYYAGIGIAVLTTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDC--NS 194
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIIS 280
L++ D + D+ I +Q + + ++ F W++TLV+++ PLI
Sbjct: 195 VGKLNTPFSVDFNKINDSSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGL 254
Query: 281 GHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKR 340
G L + F KAY KA +A E +S++RTVAAF E+K ++ Y LV +
Sbjct: 255 GAAIIGLSVSKFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRW 314
Query: 341 SFKRGQIAGIFYGISQFFIFSSYGLALWYGSVL-LEKELASFKSIMKSFMVLIVTALAMG 399
++G + G F G IF Y LA WYGS L LE+ S ++++ F+ +I+ AL +G
Sbjct: 315 GIRKGIVMGFFTGYMWCLIFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLG 374
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
G SSIF+ IDRK I + + G +L ++G IE + F YPSRP
Sbjct: 375 NASPCLEAFAAGRAAASSIFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPE 434
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
V I + ++++ G+ ALVG SG+GKS+ + LI RFY PT G V ++ DI+ +++ L
Sbjct: 435 VKILNNLSMVIKPGEMTALVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWL 494
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R QIG+V+QEP LF +I + I YG+E+A+ ++I+AAK A+A+NFI LP+ + T G+
Sbjct: 495 RNQIGIVEQEPVLFFHTIAEKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
G +SGGQKQRVAIARA++RNPKILLLD ATSALD ESE
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESE 594
Score = 60.1 bits (144), Expect = 2e-08
Identities = 26/53 (49%), Positives = 37/53 (69%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP 55
GRT +++AHRLSTI+N+D+IAV+ G V+E G HEEL+ + Y + G P
Sbjct: 1267 GRTCIVIAHRLSTIQNSDIIAVMSQGMVIEKGTHEELMVQKGAYYKLVTTGSP 1319
>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 362 bits (930), Expect = 1e-99
Identities = 235/653 (35%), Positives = 347/653 (52%), Gaps = 41/653 (6%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
G T + VAHRLST++ AD+I E G VE G HEEL+ +Y LV Q D +
Sbjct: 607 GHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLER-KGVYFMLVTLQSQGDNAHK 665
Query: 63 QSSSL---------------KNSAEISHAATIGGSFHSDRSSIGH----ALADEPRSV-- 101
++S + + S S A+I S S + H A+AD S
Sbjct: 666 ETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKD 725
Query: 102 ----------VKPRHVSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSY 151
V+P V I Y++ P W Y + G+L+A GA+ P+++L S L ++
Sbjct: 726 SKDNDVLVEEVEPAPVRRILKYNI--PEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTF 783
Query: 152 -YMDWDSTCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNE 210
+D + E+ + F V+I ++ +F GE LT R+R A+L +
Sbjct: 784 SLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQD 843
Query: 211 IGWFDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLV 270
IGWFDD RN +L++RL TDA+ ++ + +++ + ++ AL+IAF +W+++L+
Sbjct: 844 IGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLI 903
Query: 271 VLATYP-LIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDL 329
+ +P L +SG + K+ + GF +A KA + EA+SNIRTVA E + I
Sbjct: 904 ITIFFPFLALSGAVQTKM-LTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKA 962
Query: 330 YADELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFM 389
+ EL K + ++ I G+ + SQ F + A YG L+ E F + +
Sbjct: 963 FEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVS 1022
Query: 390 VLIVTALAMGETLALAPDLLKGNQMVSSIFDMIDRKS--GIIHDVGEELMTVEGMIELKR 447
+ ++A A+G T + P K + F ++DRK + + GE+ +G I+
Sbjct: 1023 SVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFID 1082
Query: 448 INFIYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGK 507
F YPSRP++ + ++ V G++LA VG SG GKS+ I L+ RFYDP G VMIDG
Sbjct: 1083 CKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGH 1142
Query: 508 DIKKMNLKSLRKQIGLVQQEPALFATSIYKNILYG--KEEASESEVIEAAKLADAHNFIS 565
D KK+N++ LR IG+V QEP LF SI NI YG +E S I AAK A H+F+
Sbjct: 1143 DSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVM 1202
Query: 566 ALPEGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESER 618
+LPE Y T G +G LS G+KQR+AIARAI+R+PKILLLDEATSALD ESE+
Sbjct: 1203 SLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
Score = 321 bits (823), Expect = 3e-87
Identities = 185/460 (40%), Positives = 275/460 (59%), Gaps = 5/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ K + ++ G + + + + I G R R+R I I++ EIGWFD T +
Sbjct: 137 EMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCT--S 194
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIIS 280
L+SR D + + D+ LQ + + L++ F W++TLV+LA PLI
Sbjct: 195 VGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGI 254
Query: 281 GHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKR 340
G L + F KAY KA +A E +S+IRTVAAF E K ++ Y LV +
Sbjct: 255 GAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRW 314
Query: 341 SFKRGQIAGIFYGISQFFIFSSYGLALWYGSVL-LEKELASFKSIMKSFMVLIVTALAMG 399
+G + G F G IF Y LA WYGS L L++E + ++++ F+ +I+ A+ +G
Sbjct: 315 GIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIG 374
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
+ G ++IF IDR+ I + G +L ++G IE + F YPSRP+
Sbjct: 375 HASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPD 434
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
V I + ++++ G++ ALVG SG+GKS+ + LI RFYDP G V +DG DI+ +N++ L
Sbjct: 435 VKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWL 494
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R QIG+V+QEP LF+T+I +NI +G+E+A+ ++++AAK A+A+NFI ALP+ + T G+
Sbjct: 495 RDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGE 554
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
G +SGGQKQRVAIARA++RNPKILLLD ATSALD ESE
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESE 594
Score = 61.2 bits (147), Expect = 8e-09
Identities = 26/53 (49%), Positives = 39/53 (73%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP 55
GRT +++AHRLSTI+N+D+IAVV G V+E G HE+L++ + Y ++ G P
Sbjct: 1267 GRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLVITGAP 1319
>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11)
Length = 1321
Score = 361 bits (926), Expect = 4e-99
Identities = 217/650 (33%), Positives = 336/650 (51%), Gaps = 35/650 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
G T + VAHRLST++ AD I E G+ VE G HEEL+ +Y +LV Q + +L
Sbjct: 607 GHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLER-KGVYFTLVTLQSQGNQALN 665
Query: 63 QSSSLKNSAEISHAATIGGSFHSD----------RSSIGHALADEPRSVVKPRHV----- 107
+ + + A T + D +S + + + + P +VV +
Sbjct: 666 EEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDR 725
Query: 108 --------------SLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYM 153
+ R+ P W Y + G++ A G + PL+A S L ++ +
Sbjct: 726 KDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSI 785
Query: 154 -DWDSTCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIG 212
D + ++ + LF V++ ++ +F GE LT R+R A+L +I
Sbjct: 786 PDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIA 845
Query: 213 WFDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVL 272
WFDD RN+ L++RL TDA+ ++ + +++ + V A++IAF +W+++LV+L
Sbjct: 846 WFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVIL 905
Query: 273 ATYPLIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYAD 332
+P + + + GF +A + EA+SNIRTVA E + I+
Sbjct: 906 CFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALET 965
Query: 333 ELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLI 392
EL +P K + ++ I G + +Q +F + + YG L+ E F + + ++
Sbjct: 966 ELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVV 1025
Query: 393 VTALAMGETLALAPDLLKGNQMVSSIFDMIDRKS--GIIHDVGEELMTVEGMIELKRINF 450
++A A+G + P K + F ++DR+ + + GE+ +G I+ F
Sbjct: 1026 LSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKF 1085
Query: 451 IYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIK 510
YPSRP+ + ++ + G++LA VG SG GKS+ I L+ RFYDP GKVMIDG D K
Sbjct: 1086 TYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSK 1145
Query: 511 KMNLKSLRKQIGLVQQEPALFATSIYKNILYG--KEEASESEVIEAAKLADAHNFISALP 568
K+N++ LR IG+V QEP LFA SI NI YG +E VI AAK A H+F+ +LP
Sbjct: 1146 KVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLP 1205
Query: 569 EGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESER 618
E Y T G +G LS G+KQR+AIARAI+R+PKILLLDEATSALD ESE+
Sbjct: 1206 EKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
Score = 325 bits (833), Expect = 2e-88
Identities = 182/460 (39%), Positives = 274/460 (59%), Gaps = 5/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
E+ K A + G A+ + I+ + I R ++R I++ EIGWFD N+
Sbjct: 137 EMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--NS 194
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIIS 280
L++R D + + D+ + +Q + + ++ F W++TLV+++ PLI
Sbjct: 195 VGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGI 254
Query: 281 GHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKR 340
G L + F KAY KA ++A E +S++RTVAAF E++ ++ Y LV +
Sbjct: 255 GAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW 314
Query: 341 SFKRGQIAGIFYGISQFFIFSSYGLALWYGSVL-LEKELASFKSIMKSFMVLIVTALAMG 399
++G + G F G IF Y +A WYGS L L++ + ++++ F+ +IV AL +G
Sbjct: 315 GIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLG 374
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
G +SIF+ IDRK I + + G +L ++G IE + F YPSRP
Sbjct: 375 NASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPE 434
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
V I D N+++ G+ ALVG SG+GKS+ + LI RFYDP G V +DG DI+ +N++ L
Sbjct: 435 VKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWL 494
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R QIG+V+QEP LF+T+I +NI YG+E+A+ ++++AAK A+A+NFI LP+ + T G+
Sbjct: 495 RDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
G +SGGQKQRVAIARA++RNPKILLLD ATSALD ESE
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESE 594
Score = 61.6 bits (148), Expect = 6e-09
Identities = 27/53 (50%), Positives = 38/53 (70%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP 55
GRT +++AHRLSTI+NAD+IAV+ G V+E G HEEL++ + Y + G P
Sbjct: 1267 GRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSP 1319
>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 359 bits (922), Expect = 1e-98
Identities = 227/652 (34%), Positives = 347/652 (52%), Gaps = 39/652 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNP--------------NSLYS 48
G T + VAHRLST+++AD+I E G+ VE G HEEL+ N+
Sbjct: 607 GHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLVTLQSQEDNTHKE 666
Query: 49 SLVQGQPSPDPSLGQSSSLKNSAEISHAATIGGSFHSDRSSIGH----ALADEPRSV--- 101
+ ++G+ + + + + + S + S A+I S S + H A+ D S
Sbjct: 667 TGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLSHEPPLAIGDHKSSYEDR 726
Query: 102 ---------VKPRHVSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYY 152
V+P V I Y++ W Y + G L A GA+ P+++L S L ++
Sbjct: 727 KDNDVLVEEVEPAPVRRILKYNI--SEWPYILVGALCAAINGAVTPIYSLLFSQILKTFS 784
Query: 153 M-DWDSTCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEI 211
+ D + E+ + F V++ ++ +F GE LT R+R A+L+ +I
Sbjct: 785 LVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDI 844
Query: 212 GWFDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVV 271
GWFDD +N +L++RL TDA+ ++ + +++ + + A++IAF+ NW+++LV+
Sbjct: 845 GWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVI 904
Query: 272 LATYP-LIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLY 330
+P L +SG + K+ + GF + KA + EA+SNIRTVA E + I +
Sbjct: 905 SVFFPFLALSGAVQTKM-LTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAF 963
Query: 331 ADELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMV 390
EL + K + ++ + G+ Y SQ F + A YG L+ E +F + +
Sbjct: 964 EVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSS 1023
Query: 391 LIVTALAMGETLALAPDLLKGNQMVSSIFDMIDRKS--GIIHDVGEELMTVEGMIELKRI 448
+ ++A A+G T + P K + F ++DRK + GE+ +G I+
Sbjct: 1024 IAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDC 1083
Query: 449 NFIYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKD 508
F YPSRP++ + ++ V G++LA VG SG GKS+ I L+ RFYDP G VMIDG D
Sbjct: 1084 KFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHD 1143
Query: 509 IKKMNLKSLRKQIGLVQQEPALFATSIYKNILYG--KEEASESEVIEAAKLADAHNFISA 566
KK+N++ LR IG+V QEP LF SI NI YG +E S I AAK A H+F+ +
Sbjct: 1144 SKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMS 1203
Query: 567 LPEGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESER 618
LPE Y T G +G LS G+KQR+AIARAI+R+PKILLLDEATSALD ESE+
Sbjct: 1204 LPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
Score = 317 bits (812), Expect = 6e-86
Identities = 181/460 (39%), Positives = 272/460 (58%), Gaps = 5/460 (1%)
Query: 161 EVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNT 220
EV K + ++ G + + + + I G R ++R I++ EIGWFD T +
Sbjct: 137 EVIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCT--S 194
Query: 221 SSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIIS 280
L+SR D + + D+ + LQ + ++ L++ F W++TLV+LA PLI
Sbjct: 195 VGELNSRFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGI 254
Query: 281 GHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKR 340
G L + F KAY KA +A E +S+IRTVAAF E K ++ Y L+ +
Sbjct: 255 GAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRW 314
Query: 341 SFKRGQIAGIFYGISQFFIFSSYGLALWYGS-VLLEKELASFKSIMKSFMVLIVTALAMG 399
+G + G F G IF Y LA WYGS ++L++ + ++++ F+ +I+ A+ +G
Sbjct: 315 GIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIG 374
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPN 457
+ G SSIF IDR+ + + G +L ++G IE + F YPSRP
Sbjct: 375 NASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPE 434
Query: 458 VVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSL 517
V I + ++++ G++ A VG SG+GKS+ + LI RFYDP G V +DG DI+ +N++ L
Sbjct: 435 VKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWL 494
Query: 518 RKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGD 577
R QIG+V+QEP LF+T+I +NI G+EEA+ ++++AAK A+A+NFI ALP+ + T G+
Sbjct: 495 RDQIGIVEQEPVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGE 554
Query: 578 RGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
G +SGGQKQRVAIARA++R PKILLLD ATSALD ESE
Sbjct: 555 GGGQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESE 594
Score = 58.2 bits (139), Expect = 6e-08
Identities = 24/53 (45%), Positives = 38/53 (71%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP 55
GRT +++AHRLSTI+N+D+IAV+ G V+E G H++L+ + Y ++ G P
Sbjct: 1267 GRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLVITGAP 1319
>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
(P-glycoprotein 49)
Length = 1302
Score = 351 bits (900), Expect = 4e-96
Identities = 229/652 (35%), Positives = 343/652 (52%), Gaps = 38/652 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLV----------- 51
G TT++VAHRLSTI NAD I ++ G V E G HEEL+ LY LV
Sbjct: 589 GPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSITQRKEATEA 647
Query: 52 -----------QGQPSPDPSLGQSSSLKNSAEISHAATIGGSFHSD-RSSIGHALADEPR 99
+ Q D + E T G S S R+S + R
Sbjct: 648 DEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRR 707
Query: 100 SVVKPRHV----SLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFAL--GISHALVSYYM 153
K + V S +L + P W + V G +A+ GA PL+ L G ++S
Sbjct: 708 KKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGD 767
Query: 154 DWDSTCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGW 213
D D EV KI+ +F G ++A ++ F G ++T R+R I+ +I +
Sbjct: 768 D-DVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAY 826
Query: 214 FDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLA 273
FDD RN+ L SRL +D + ++ R +LQ V +V +V+ F+ +W+ TL+ L
Sbjct: 827 FDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLV 886
Query: 274 TYPLIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADE 333
T PL+ E F+ + +A+ +A EA++NIRTV C E +V+D Y +
Sbjct: 887 TLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQ 946
Query: 334 LVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIV 393
+ ++ + G+ + + Q F +YG++++YG +L+ +E +++ I+K LI
Sbjct: 947 IDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIF 1006
Query: 394 TALAMGETLALAPDLLKGNQMVSSIFDMIDRKSGIIHDVGEELMTV---EGMIELKRINF 450
+ +G+ LA AP++ + D+ R S + TV EG I + + F
Sbjct: 1007 GSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGF 1066
Query: 451 IYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIK 510
YP+R I + NL + ++ALVG SGSGKS+ + L+LR+YDP SG V + G
Sbjct: 1067 EYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPST 1126
Query: 511 KMNLKSLRKQIGLVQQEPALFATSIYKNILYG---KEEASESEVIEAAKLADAHNFISAL 567
+ L +LR ++GLV QEP LF +I +NI YG +++ S E+IEAAK ++ HNFISAL
Sbjct: 1127 EFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISAL 1186
Query: 568 PEGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
P+GY T+ G + LSGGQKQR+AIARA++RNPKIL+LDEATSALD+ESE+V
Sbjct: 1187 PQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKV 1237
Score = 276 bits (707), Expect = 9e-74
Identities = 159/431 (36%), Positives = 258/431 (58%), Gaps = 12/431 (2%)
Query: 197 RVRGIMLSAILKNEIGWFDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTA 256
R+R + L A+L+ +I W+D + + S +S++ D LK + ++ I++ + V
Sbjct: 150 RIRKLFLEAMLRQDIAWYDTS--SGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIG 207
Query: 257 LVIAFILNWRITLVVLATYPLIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRT 316
+V AF+ W++TLVVL+ P II+ K+Y A + E S IRT
Sbjct: 208 IVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRT 267
Query: 317 VAAFCAEEKVIDLYADELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLL-- 374
V AF +EK + + L+ K+G +G+ +S I+ LA+WYG L+
Sbjct: 268 VFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILD 327
Query: 375 EKELASFKSIMKSFMVLIVTALAMG-ETLALAPDLLKGNQMVSS----IFDMIDRKSGI- 428
E++L + + +V+++ A+ MG + L A ++ + ++ +F++IDR S +
Sbjct: 328 ERDLPD-RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVD 386
Query: 429 -IHDVGEELMTVEGMIELKRINFIYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSI 487
+ + G G I + I F YP+RP+V I K + V G+++A VG SG GKS++
Sbjct: 387 PMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTL 446
Query: 488 ISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLVQQEPALFATSIYKNILYGKEEAS 547
I L+ RFYDP +G V +DG+D++ +N+ LR QIG+V QEP LFAT+I +NI YG+ A+
Sbjct: 447 IQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSAT 506
Query: 548 ESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDE 607
++++ +AA+ A+ H+FI+ LP+GY T+ G++G +SGGQKQR+AIARA++R P++LLLDE
Sbjct: 507 QADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDE 566
Query: 608 ATSALDVESER 618
ATSALD SE+
Sbjct: 567 ATSALDPTSEK 577
Score = 52.4 bits (124), Expect = 4e-06
Identities = 24/48 (50%), Positives = 38/48 (79%), Gaps = 1/48 (2%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSL 50
GRT + +AHRL+T++NAD+I V++ G VVE G H+EL++ N +Y++L
Sbjct: 1248 GRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMA-LNKIYANL 1294
>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
(P-glycoprotein 65)
Length = 1302
Score = 330 bits (846), Expect = 7e-90
Identities = 215/650 (33%), Positives = 349/650 (53%), Gaps = 36/650 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLG 62
GRTT++V+HRLS I+ AD I + G V+E G+H++L++ + Y+ + G + +
Sbjct: 592 GRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVE 651
Query: 63 QSSSLKNSAEISHAATIGGSFHS-----DRSSIGHALADEP--RSVVK----------PR 105
+ S++++ + S A SF + ++ +EP ++++K P
Sbjct: 652 KEDSIEDTKQKS-LALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPE 710
Query: 106 HVSLIRLYSMI----GPYWSYGVFGTLAAFTTGALMPLFAL--GISHALVSYYMDWDSTC 159
+ R +S I W Y + GT++A G L P FA+ G +A ++ D +
Sbjct: 711 KPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAE-KDPEDAL 769
Query: 160 HEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRN 219
+++ G A + ++ F G LT R+R + +A++ E+GWFDD N
Sbjct: 770 RRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENN 829
Query: 220 TSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLII 279
+ LS+RL +A ++ + + ++Q + ++++ +A NW++ L+ LA P+I+
Sbjct: 830 SVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV 889
Query: 280 SGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSK 339
I E M + +A +A E+++NIRTVA E VI Y +E+
Sbjct: 890 GSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEV 949
Query: 340 RSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMG 399
++ + G+ Q F +Y +AL YG VL+ + F+ I+K L+ ++ +
Sbjct: 950 LIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLA 1009
Query: 400 ETLALAPDLLKGNQMVSSIFDMIDRKSGIIHDVG-------EELMTVEGMIELKRINFIY 452
++LA P +F ++DRK I +G ++L EG + + I F Y
Sbjct: 1010 QSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRY 1068
Query: 453 PSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKK- 511
P+RP+ I +L V G+++ALVGHSG GKS+ + L+ R+YDP G + ID DI+
Sbjct: 1069 PTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHD 1128
Query: 512 MNLKSLRKQIGLVQQEPALFATSIYKNILYGKEEASES--EVIEAAKLADAHNFISALPE 569
+ L +R ++G+V QEP LF SI +NI YG S S E+I AAK A+AH+FI +LP
Sbjct: 1129 LTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPN 1188
Query: 570 GYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
GY T+ G RG LSGGQKQR+AIARA++RNPKILLLDEATSALD++SE++
Sbjct: 1189 GYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQL 1238
Score = 251 bits (642), Expect = 3e-66
Identities = 157/441 (35%), Positives = 245/441 (54%), Gaps = 11/441 (2%)
Query: 187 FGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSSRLETDATLLKTIVVDRSTIL 246
F ++ R R+R + S++++ +IGW D + + S ++ + I +
Sbjct: 142 FNMVALRQVTRMRIKLFSSVIRQDIGWHD-LASKQNFTQSMVDDVEKIRDGISEKVGHFV 200
Query: 247 LQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGEKLFMQGFGGNLSKAYLKANML 306
VG ++T + I+F W++TL V + PL+I + F ++Y A L
Sbjct: 201 YLVVGFIIT-VAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNL 259
Query: 307 AGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLA 366
A E +S+IRTV +F E+ + Y + LV K S +G +G+ + + ++ S A
Sbjct: 260 AEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGA 319
Query: 367 LWYGSVLL------EKELASFKSIMKSFMVLIVTALAMGETLALAPDLLKGNQMVSSIFD 420
WYG L+ E + + +M +F +IV A + T +++F
Sbjct: 320 FWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFK 379
Query: 421 MIDRKSGI--IHDVGEEL-MTVEGMIELKRINFIYPSRPNVVIFKDFNLIVPSGKSLALV 477
+ID S I + G+ L + G +E + + F YPSRP V++ + N+ + +G+++ALV
Sbjct: 380 VIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALV 439
Query: 478 GHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLVQQEPALFATSIYK 537
G SG GKS+ + L+ RFYDP G V++D DI+K N++ LR I +V QEP LF +I +
Sbjct: 440 GSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQ 499
Query: 538 NILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLSGGQKQRVAIARAIL 597
NI YGK A++ E+ AA A AH FI+ LPE Y + G+RG LSGGQKQR+AIARA++
Sbjct: 500 NISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALI 559
Query: 598 RNPKILLLDEATSALDVESER 618
+NPKILLLDEATSALD +SE+
Sbjct: 560 QNPKILLLDEATSALDYQSEK 580
Score = 58.9 bits (141), Expect = 4e-08
Identities = 27/52 (51%), Positives = 39/52 (74%), Gaps = 1/52 (1%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQ 54
GRT +++AHRLST++NAD+I V++ G VVE GNH +LIS +Y+ L + Q
Sbjct: 1249 GRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQ-GGIYAKLHKTQ 1299
>PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1
Length = 1362
Score = 315 bits (806), Expect = 3e-85
Identities = 191/510 (37%), Positives = 279/510 (54%), Gaps = 22/510 (4%)
Query: 126 GTLAAFTTGALMPLFALGISHALVSYYMDW------DSTCHEVKKIAFLFCGAAIVAITA 179
GT+ G MPL +L +S L + D S H V F AI
Sbjct: 98 GTITGIGAGLGMPLMSL-VSGQLAQAFTDLASGKGASSFQHTVDHFCLYFIYIAIGVFGC 156
Query: 180 YSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSSRLETDATLLKTIV 239
I ++F I GER+ R+R L AIL IG+FD R + +++R+ TD ++ +
Sbjct: 157 SYIYTVTFIIAGERIARRIRQDYLHAILSQNIGYFD--RLGAGEITTRITTDTNFIQDGL 214
Query: 240 VDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISG-HIGEKLFMQGFGGNLSK 298
++ ++ + V+ VIAFI +W+ TL++ + +P I G +G + G ++
Sbjct: 215 GEKVGLVFFAIATFVSGFVIAFIRHWKFTLILSSMFPAICGGIGLGVPFITKNTKGQIA- 273
Query: 299 AYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQIAGIFYGISQFF 358
+++ E SNIR AF ++ + LY L+ + + G+ G F
Sbjct: 274 VVAESSTFVEEVFSNIRNAFAFGTQDILAKLYNKYLITAQRFGINKAIAMGLMVGWMFFV 333
Query: 359 IFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAPDLLKGNQMVSSI 418
+ YGLA W G LL ++ F +++ + ++ + I
Sbjct: 334 AYGVYGLAFWEGGRLLHAGDLDVSKLIGCFFAVLIASYSLANISPKMQSFVSCASAAKKI 393
Query: 419 FDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVVIFKDFNLIVPSGKSLAL 476
FD IDR S I G+ + ++G IELK I F+YP+RP V++ +F+L+ PSGK AL
Sbjct: 394 FDTIDRVSPINAFTPTGDVVKDIKGEIELKNIRFVYPTRPEVLVLDNFSLVCPSGKITAL 453
Query: 477 VGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLVQQEPALFATSIY 536
VG SGSGKS+II L+ RFYDP G+V +DGKD++ +N+ SLR QI LVQQEP LFAT+++
Sbjct: 454 VGASGSGKSTIIGLVERFYDPIGGQVFLDGKDLRTLNVASLRNQISLVQQEPVLFATTVF 513
Query: 537 KNILYG---------KEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLSGGQK 587
+NI YG +E E V +AAKLA+A++FI LPE +ST G RG L+SGGQK
Sbjct: 514 ENITYGLPDTIKGTLSKEELERRVYDAAKLANAYDFIMTLPEQFSTNVGQRGFLMSGGQK 573
Query: 588 QRVAIARAILRNPKILLLDEATSALDVESE 617
QR+AIARA++ +PKILLLDEATSALD +SE
Sbjct: 574 QRIAIARAVISDPKILLLDEATSALDSKSE 603
Score = 297 bits (760), Expect = 6e-80
Identities = 211/685 (30%), Positives = 336/685 (48%), Gaps = 74/685 (10%)
Query: 4 RTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPSPDPSLGQ 63
RTT+++AHRLSTI+NAD I VV G +VE G+H EL+ + N Y+ LV+ Q Q
Sbjct: 617 RTTIVIAHRLSTIRNADNIVVVNAGKIVEQGSHNELL-DLNGAYARLVEAQKLSGGEKDQ 675
Query: 64 S---------------SSLKNSAEISHAATIGG---SFHSDRSSIGHALADEPRSVVKPR 105
+S + E + A++ S ++D ++ + L ++ V + +
Sbjct: 676 EMVEEELEDAPREIPITSFGDDDEDNDMASLEAPMMSHNTDTDTLNNKLNEKDNVVFEDK 735
Query: 106 HVSLIRLYSMIGPYWSYGVFGTL---------AAFTTGALMPLFALGISHALVSYYMDWD 156
+L + S I P G L + + L AL H+ V + +
Sbjct: 736 --TLQHVASEIVPNLPPADVGELNEEPKKSKKSKKNNHEINSLTALWFIHSFVRTMI--E 791
Query: 157 STCHEVKKIAFLFCGAA-----------------------------------IVAIT--- 178
C + +A + CGAA I+AI
Sbjct: 792 IICLLIGILASMICGAAYPVQAAVFARFLNIFTDLSSTDFLHKVNVFAVYWLILAIVQFF 851
Query: 179 AYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSSRLETDATLLKTI 238
AY+I + + E + R+R + +L+ ++ +FD + NT +++ L T L+ +
Sbjct: 852 AYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFDRSENTVGAITTSLSTKIQSLEGL 911
Query: 239 VVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGEKLFMQGFGGNLSK 298
Q + +++ +++ W++ LV L+T P+II+ + LS
Sbjct: 912 SGPTLGTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVRALDQVQEKLSA 971
Query: 299 AYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQIAGIFYGISQFF 358
AY ++ A E+ S IRTVA+ EE V Y D L++P + S +G+F+ +Q
Sbjct: 972 AYKESAAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIASLKSGLFFSAAQGV 1031
Query: 359 IFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAPDLLKGNQMVSSI 418
F L WYGS L+ K + F+ ++ G+ + D+ K I
Sbjct: 1032 TFLINALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSADVTKAKAAAGEI 1091
Query: 419 FDMIDRKSGI--IHDVGEELMTVE-GMIELKRINFIYPSRPNVVIFKDFNLIVPSGKSLA 475
+ + K I G+++ +++ IE +++ F YP+R ++ + + NL V G+ +A
Sbjct: 1092 KYLSESKPKIDTWSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGLNLTVKPGQFVA 1151
Query: 476 LVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLVQQEPALFATSI 535
VG SG GKS+ I LI RFYD +G V++DG +++ N+ RKQI LV QEP L+ ++
Sbjct: 1152 FVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNINDYRKQIALVSQEPTLYQGTV 1211
Query: 536 YKNILYG-KEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLSGGQKQRVAIAR 594
+NI+ G ++ SE E+IEA K A+ H FI LP GY+T G +G LSGGQKQR+AIAR
Sbjct: 1212 RENIVLGASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQKGSSLSGGQKQRIAIAR 1271
Query: 595 AILRNPKILLLDEATSALDVESERV 619
A++RNPKILLLDEATSALD SE+V
Sbjct: 1272 ALIRNPKILLLDEATSALDSHSEKV 1296
Score = 53.1 bits (126), Expect = 2e-06
Identities = 24/50 (48%), Positives = 33/50 (66%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQ 52
GRTTV +AHRLS+I++AD I V +GG + E G H EL+ Y +V+
Sbjct: 1307 GRTTVAIAHRLSSIQDADCIFVFDGGVIAEAGTHAELVKQRGRYYELVVE 1356
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein A)
Length = 1321
Score = 312 bits (799), Expect = 2e-84
Identities = 204/653 (31%), Positives = 329/653 (50%), Gaps = 36/653 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYS------------SL 50
GRTT+I+AHRLSTI+NAD+I + G VVE G+H L++ Y S
Sbjct: 603 GRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSA 662
Query: 51 VQGQPSPDPSLG-----------QSSSLKNSAEISHAATIGGSFHSD-----RSSIGHAL 94
+G+ S + S+ Q+S + + ++TIG + IG
Sbjct: 663 AEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDA 722
Query: 95 ADEPRSVVKPRHVSLIRLYSMI---GPYWSYGVFGTLAAFTTGALMPLFALGISHALVSY 151
+ ++ + L+ ++ P+ G A G + P +++ + + +
Sbjct: 723 LSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVF 782
Query: 152 YMDWDSTCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEI 211
+ + A +F A + GI E LT +R + +L I
Sbjct: 783 AGNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHI 842
Query: 212 GWFDDTRNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVV 271
G+FD +N S +S+RL TD L+T + R + ++ + +V + +AF W++ L++
Sbjct: 843 GFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLI 902
Query: 272 LATYPLIISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYA 331
+A P++ G G + + + +A EA+ N+RTV A E+ + +
Sbjct: 903 IAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFC 962
Query: 332 DELVEPSKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKS--IMKSFM 389
++L P K + K I G+ YG + ++ A G L+ + + + +++
Sbjct: 963 EKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMY 1022
Query: 390 VLIVTALAMGETLALAPDLLKGNQMVSSIFDMIDRKSGIIH-DVGEELMTVEGMIELKRI 448
+ ++ +G + P+ K IF M+ + S I + E + G + K +
Sbjct: 1023 AITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNV 1082
Query: 449 NFIYPSRPNVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKD 508
F YP RP + I K + V G++LALVG SG GKS++++L+ RFYD G++ IDG +
Sbjct: 1083 RFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSE 1142
Query: 509 IKKMNLKSLRKQIGLVQQEPALFATSIYKNILYGKEEASES--EVIEAAKLADAHNFISA 566
IK +N + R QI +V QEP LF SI +NI+YG + +S + +V EAA+LA+ HNFI+
Sbjct: 1143 IKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAE 1202
Query: 567 LPEGYSTKAGDRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
LPEG+ T+ GDRG LSGGQKQR+AIARA++RNPKILLLDEATSALD ESE+V
Sbjct: 1203 LPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKV 1255
Score = 295 bits (756), Expect = 2e-79
Identities = 182/515 (35%), Positives = 283/515 (54%), Gaps = 23/515 (4%)
Query: 126 GTLAAFTTGALMPLFAL---GISHALVSYYMDWDSTC----------------HEVKKIA 166
GTL A TGA +PL ++ +S A ++ + ++ H+V +
Sbjct: 80 GTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFLPTGQNYTKTDFEHDVMNVV 139
Query: 167 FLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSS 226
+ + + A I + + E++ R+R + +IL+ EI WFD N S L++
Sbjct: 140 WSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVKSILRQEISWFDT--NHSGTLAT 197
Query: 227 RLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIGEK 286
+L + +K D+ + Q + +T ++AF +W++TLV+LA P+
Sbjct: 198 KLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIA 257
Query: 287 LFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQ 346
M F + Y KA + E +S+IRTV + ++ Y+ + E K +G
Sbjct: 258 KSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGL 317
Query: 347 IAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAP 406
GI +G Q F S+ LA + G + +F ++ +F +++ ++A+G
Sbjct: 318 FLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLA 377
Query: 407 DLLKGNQMVSSIFDMIDRKSGIIHD--VGEELMTVEGMIELKRINFIYPSRPNVVIFKDF 464
L S I++++DRK I G + M ++G I ++ ++F YPSRP+V I +
Sbjct: 378 VLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGM 437
Query: 465 NLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLV 524
NL V +G+++ALVG SG GKS+IISL+LR+YD GK+ IDG D++ +NL+ LRK + +V
Sbjct: 438 NLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVV 497
Query: 525 QQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLSG 584
QEPALF +I +NI GKE + E++ A K+A+A FI LP GY+T GDRG LSG
Sbjct: 498 SQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSG 557
Query: 585 GQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
GQKQR+AIARA++RNPKILLLDEATSALD ESE +
Sbjct: 558 GQKQRIAIARALVRNPKILLLDEATSALDAESEGI 592
Score = 55.1 bits (131), Expect = 5e-07
Identities = 22/45 (48%), Positives = 33/45 (72%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLY 47
GRT +++AHRL+T+ NAD IAVV G+++E G H +L+S + Y
Sbjct: 1266 GRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYY 1310
>MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1280
Score = 307 bits (786), Expect = 6e-83
Identities = 203/641 (31%), Positives = 329/641 (50%), Gaps = 36/641 (5%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVV-----EGGSVVETGNHEELISNPNSLYS-SLVQGQPS 56
G T V++AHRL+TI++ D I V EG + E+G +EL+ + + +QG +
Sbjct: 580 GTTVVVIAHRLATIRDMDRIYYVKHDGAEGSRITESGTFDELLELDGEFAAVAKMQGVLA 639
Query: 57 PDPSLGQSSSLKNSAEIS-HAATIGGSFHSDRSSIGHALADEPRSV-------------V 102
D G +S++++ + S H I D + + D PR+ V
Sbjct: 640 GDAKSG--ASVRDAKKASGHLGVI-----LDEADLAQLDEDVPRTARQNVPIDELAKWEV 692
Query: 103 KPRHVSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHAL-----VSYYMDWDS 157
K V +RL M G L++ G+ P ++ + H L S D ++
Sbjct: 693 KHAKVGFLRLMRMNKDKAWAVALGILSSVVIGSARPASSIVMGHMLRVLGEYSATKDVEA 752
Query: 158 TCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDT 217
A LF A+ + + I H +G GE LT ++R ++ I++ +I +FD
Sbjct: 753 LRSGTNLYAPLFIVFAVANFSGW-ILHGFYGYAGEHLTTKIRVLLFRQIMRQDINFFDIP 811
Query: 218 RNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPL 277
+ L+ L D + + + +Q + ++ + LV+ FI W++ LV LA PL
Sbjct: 812 GRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTMCIIASGLVVGFIYQWKLALVALACMPL 871
Query: 278 IISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEP 337
+I + +L + G+ S+ + + EA+SN+RTV + +E ++ + L E
Sbjct: 872 MIGCSLTRRLMINGY--TKSREGDTDDTIVTEALSNVRTVTSLNMKEDCVEAFQAALREE 929
Query: 338 SKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALA 397
+ RS ++G IAG YGI+QF + Y L WYGS L++K A FK +M + M ++ A
Sbjct: 930 APRSVRKGIIAGGIYGITQFIFYGVYALCFWYGSKLIDKGEAEFKDVMIASMSILFGAQN 989
Query: 398 MGETLALAPDLLKGNQMVSSIFDMIDRKSGI-IHDVGEELMTVEGMIELKRINFIYPSRP 456
GE A A L +F +IDR + I G + + IE + + FIY +RP
Sbjct: 990 AGEAGAFATKLADAEASAKRVFSVIDRVPDVDIEQAGNKDLGEGCDIEYRNVQFIYSARP 1049
Query: 457 NVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKS 516
V+ N+ S L+G +G GKS++I ++ RFY+ SG + ++G+D+ +++
Sbjct: 1050 KQVVLASVNMRFGDATSNGLIGQTGCGKSTVIQMLARFYERRSGLISVNGRDLSSLDIAE 1109
Query: 517 LRKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAG 576
R+ I +V QEP LF+ ++ +NI Y +E A++ EV EAA+LA H+ I +GY T+ G
Sbjct: 1110 WRRNISIVLQEPNLFSGTVRENIRYAREGATDEEVEEAARLAHIHHEIIKWTDGYDTEVG 1169
Query: 577 DRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESE 617
+G LSGGQKQR+AIAR +LR P++LLLDEATSALD +E
Sbjct: 1170 YKGRALSGGQKQRIAIARGLLRRPRLLLLDEATSALDSVTE 1210
Score = 269 bits (687), Expect = 2e-71
Identities = 160/499 (32%), Positives = 267/499 (53%), Gaps = 11/499 (2%)
Query: 124 VFGTLAAFTTGALMPLFALGISHALVSYYMDWDSTCHEVKKIAFLFCGAAIVAITAYSIE 183
+ GT A GA MP+F+ + S + K + + I + A +
Sbjct: 73 IAGTAFAVACGAGMPVFSFIFGRIAMDLMSGVGSAEEKAAKTSLIMVYVGIAMLIACAGH 132
Query: 184 HLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSMLSSRLETDATLLKTIVVDRS 243
+ + + R R+R + A+L+ +IGW D+ ++ L++R+ D +++ + D+
Sbjct: 133 VMCWTVAACRQVARIRLLFFRAVLRQDIGWHDE--HSPGALTARMTGDTRVIQNGINDKL 190
Query: 244 TILLQNVGLVVTALVIAFILNWRITLVVLATYPLII--SGHIGEKLFMQGFGGNLSKAYL 301
+ + N + V + F+ +W +TL+++ P II + IG + + K +
Sbjct: 191 SQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGS--IVSKITESSRKYFA 248
Query: 302 KANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKRGQIAGIFYGISQFFIFS 361
KA LA E + NIRTV AF E+ ++ + ++ R ++ + + + ++
Sbjct: 249 KAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYV 308
Query: 362 SYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLALAPDLLKGNQMVSSIFDM 421
SY +A ++GS L+E I+ +F+ +++ + +G + IF
Sbjct: 309 SYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKA 368
Query: 422 IDRKSGIIHDVGEELMTVEGM---IELKRINFIYPSRPNVVIFKDFNLIVPSGKSLALVG 478
IDR + D G + V G IE + + F YP+RP +++F+D +L + G+ +A G
Sbjct: 369 IDRVPPVDIDAGG--VPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSG 426
Query: 479 HSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIGLVQQEPALFATSIYKN 538
SG GKSS+I LI RFYDP G V++DG ++++ L+ R QIG+V QEP LFA ++ +N
Sbjct: 427 ASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPNLFAGTMMEN 486
Query: 539 ILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLLSGGQKQRVAIARAILR 598
+ GK A++ EV+EA + A+ H+ I ALP+ Y T G G LLSGGQKQR+AIARA+++
Sbjct: 487 VRMGKPNATDEEVVEACRQANIHDTIMALPDRYDTPVGPVGSLLSGGQKQRIAIARALVK 546
Query: 599 NPKILLLDEATSALDVESE 617
P ILLLDEATSALD +SE
Sbjct: 547 RPPILLLDEATSALDRKSE 565
Score = 46.2 bits (108), Expect = 3e-04
Identities = 18/37 (48%), Positives = 30/37 (80%)
Query: 5 TTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELIS 41
TTV +AHRL+TI++ D I +++ G ++E G+HEEL++
Sbjct: 1227 TTVSIAHRLTTIRHCDQIILLDSGCIIEQGSHEELMA 1263
>MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprotein C)
Length = 1268
Score = 292 bits (747), Expect = 2e-78
Identities = 192/643 (29%), Positives = 318/643 (48%), Gaps = 26/643 (4%)
Query: 3 GRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQP----SPD 58
GRTT+ +AHRLSTI+NA I V + G + E G H+ELIS + +Y+S+V+ Q D
Sbjct: 563 GRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKED 622
Query: 59 PSLGQSSSLK-------NSAEISHAATIGGSFHSDRSSIGHALADEPRSVVK-------- 103
+L K +S + S D + + ++ V +
Sbjct: 623 TTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENARE 682
Query: 104 ------PRHVSLIRLYSMIGPYWSYGVFGTLAAFTTGALMPLFALGISHALVSYYMDWDS 157
SL ++ P + + G P F++ D
Sbjct: 683 EMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDD 742
Query: 158 TCHEVKKIAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDT 217
+ + F A + I G GE ++ R+R + I++ + +FDD+
Sbjct: 743 VSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDS 802
Query: 218 RNTSSMLSSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPL 277
R+ L+SRL TDA ++ + R +L + + + +AF W + + LAT L
Sbjct: 803 RHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALL 862
Query: 278 IISGHIGEKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEP 337
++ +++ G + ++A+ L E++SN +TV A +E + D + P
Sbjct: 863 LVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSP 922
Query: 338 SKRSFKRGQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALA 397
+R+ RG + + ++ F+ ++ +A +G L+ ++ ++ + L + +++
Sbjct: 923 HRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMS 982
Query: 398 MGETLALAPDLLKGNQMVSSIFDMIDRKSGIIH-DVGEELMTVEGMIELKRINFIYPSRP 456
+ + P+ ++ +F MI +KS I + + + T++G I ++ + F YP+R
Sbjct: 983 VMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRR 1042
Query: 457 NVVIFKDFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKS 516
++ FN+ G+++ALVG SG GKS+ I LI R+YD G V ID DI+ +++K
Sbjct: 1043 RQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKH 1102
Query: 517 LRKQIGLVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAG 576
LR I LV QEP LF +I +NI YG E ++ +V +AA LA+ H F+ LP+GY T G
Sbjct: 1103 LRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVG 1162
Query: 577 DRGVLLSGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
G LSGGQKQRVAIARAI+R+PKILLLDEATSALD ESE++
Sbjct: 1163 ASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKI 1205
Score = 264 bits (675), Expect = 5e-70
Identities = 171/517 (33%), Positives = 274/517 (52%), Gaps = 20/517 (3%)
Query: 119 YWSYGVF--GTLAAFTTGALMPLFAL---GISHALV---SYY------MDWDSTCHEVKK 164
Y Y +F G + + GAL+P +L GI++AL+ S Y M W S+ ++
Sbjct: 40 YKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINMPWFSSEIKMFC 99
Query: 165 IAFLFCGAAIVAITAYSIEHLSFGIMGERLTLRVRGIMLSAILKNEIGWFDDTRNTSSML 224
+ + + G A+ + +Y + + RL +R L ++L+ + WFD+T T L
Sbjct: 100 LRYFYLGVALF-LCSYFANSCLYTLCERRLHC-IRKKYLKSVLRQDAKWFDET--TIGGL 155
Query: 225 SSRLETDATLLKTIVVDRSTILLQNVGLVVTALVIAFILNWRITLVVLATYPLIISGHIG 284
+ ++ + +K + D+ +L+ V ++ + I F + W++TLV++ T PL +
Sbjct: 156 TQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYL 215
Query: 285 EKLFMQGFGGNLSKAYLKANMLAGEAVSNIRTVAAFCAEEKVIDLYADELVEPSKRSFKR 344
+ N AY A +A E ++ IRTV AF A+ I+ YA +L E + ++
Sbjct: 216 SAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRK 275
Query: 345 GQIAGIFYGISQFFIFSSYGLALWYGSVLLEKELASFKSIMKSFMVLIVTALAMGETLAL 404
I I +F+ +A WYG+ L S ++ F +++ +GE
Sbjct: 276 AIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPH 335
Query: 405 APDLLKGNQMVSSIFDMIDRKSGI--IHDVGEELMTVEGMIELKRINFIYPSRPNVVIFK 462
+ + IF +ID + I G+ ++G + I F YP+RP + I K
Sbjct: 336 LGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILK 395
Query: 463 DFNLIVPSGKSLALVGHSGSGKSSIISLILRFYDPTSGKVMIDGKDIKKMNLKSLRKQIG 522
+ V G+++ALVGHSG GKS+ I L++RFY+ +G + +DG I++ N++ LR IG
Sbjct: 396 GVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIG 455
Query: 523 LVQQEPALFATSIYKNILYGKEEASESEVIEAAKLADAHNFISALPEGYSTKAGDRGVLL 582
+VQQEP +F ++ +NI G ++ ++ EA K+A+AH FI L + Y T G V L
Sbjct: 456 IVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGAVQL 515
Query: 583 SGGQKQRVAIARAILRNPKILLLDEATSALDVESERV 619
SGGQKQRVAIARAI+R P+ILLLDEATSALD ESER+
Sbjct: 516 SGGQKQRVAIARAIVRKPQILLLDEATSALDTESERM 552
Score = 54.7 bits (130), Expect = 7e-07
Identities = 27/55 (49%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 2 IGRTTVIVAHRLSTIKNADMIAVVEGGSVVETGNHEELISNPNSLYSSLVQGQPS 56
+GRT V++AHRLSTI+NAD I V G +E G H+ L++ LY LV+ Q S
Sbjct: 1215 LGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLAR-RGLYYRLVEKQSS 1268
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.320 0.136 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,375,560
Number of Sequences: 164201
Number of extensions: 2639196
Number of successful extensions: 12071
Number of sequences better than 10.0: 975
Number of HSP's better than 10.0 without gapping: 870
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 9191
Number of HSP's gapped (non-prelim): 1855
length of query: 619
length of database: 59,974,054
effective HSP length: 116
effective length of query: 503
effective length of database: 40,926,738
effective search space: 20586149214
effective search space used: 20586149214
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Medicago: description of AC149574.1