BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC149547.7 - phase: 0 
         (392 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

PDP2_HUMAN (Q9P2J9) [Pyruvate dehydrogenase [Lipoamide]]-phospha...    85  3e-16
PDP1_HUMAN (Q9P0J1) [Pyruvate dehydrogenase [Lipoamide]]-phospha...    85  4e-16
PDP1_RAT (O88483) [Pyruvate dehydrogenase [Lipoamide]]-phosphata...    84  5e-16
PDP1_BOVIN (P35816) [Pyruvate dehydrogenase [Lipoamide]]-phospha...    84  5e-16
P2C1_ARATH (P49597) Protein phosphatase 2C ABI1 (EC 3.1.3.16) (P...    82  2e-15
PDP2_RAT (O88484) [Pyruvate dehydrogenase [Lipoamide]]-phosphata...    81  5e-15
FEM2_HUMAN (P49593) Ca(2+)/calmodulin-dependent protein kinase p...    79  2e-14
P2C3_SCHPO (Q09173) Protein phosphatase 2C homolog 3 (EC 3.1.3.1...    78  4e-14
P2C2_SCHPO (Q09172) Protein phosphatase 2C homolog 2 (EC 3.1.3.1...    76  1e-13
P2C2_ARATH (O04719) Protein phosphatase 2C ABI2 (EC 3.1.3.16) (P...    76  1e-13
P2C5_YEAST (Q12511) Protein phosphatase 2C homolog 5 (EC 3.1.3.1...    73  1e-12
P2CD_HUMAN (O15297) Protein phosphatase 2C delta isoform (EC 3.1...    70  7e-12
P2CD_MOUSE (Q9QZ67) Protein phosphatase 2C delta isoform (EC 3.1...    69  2e-11
FEM2_RAT (Q9WVR7) Ca(2+)/calmodulin-dependent protein kinase pho...    69  2e-11
P2CA_MOUSE (P49443) Protein phosphatase 2C alpha isoform (EC 3.1...    69  3e-11
P2C4_ARATH (P49598) Protein phosphatase 2C (EC 3.1.3.16) (PP2C)        69  3e-11
P2CA_RAT (P20650) Protein phosphatase 2C alpha isoform (EC 3.1.3...    68  4e-11
P2CA_RABIT (P35814) Protein phosphatase 2C alpha isoform (EC 3.1...    68  4e-11
P2CA_HUMAN (P35813) Protein phosphatase 2C alpha isoform (EC 3.1...    68  5e-11
P2C2_CAEEL (P49596) Probable protein phosphatase 2C T23F11.1 (EC...    64  9e-10

>PDP2_HUMAN (Q9P2J9) [Pyruvate dehydrogenase
           [Lipoamide]]-phosphatase 2, mitochondrial precursor (EC
           3.1.3.43) (PDP 2) (Pyruvate dehydrogenase phosphatase,
           catalytic subunit 2) (PDPC 2)
          Length = 529

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 67/265 (25%), Positives = 117/265 (43%), Gaps = 51/265 (19%)

Query: 142 QIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAIESVRQE 201
           Q+A  G+   +  + G  L++AN GD RA+LG      G    + L+ +HN   ++    
Sbjct: 261 QVAFSGATACMAHVDGIHLHVANAGDCRAILG-VQEDNGMWSCLPLTRDHNAWNQAELSR 319

Query: 202 MHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAE----------FNREPLYA-K 250
           +   HP+     ++  +  R+ G++   R+ GDV LK ++          FN E L   +
Sbjct: 320 LKREHPESEDRTIIMED--RLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQ 377

Query: 251 FRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQNH------- 303
           F     +  P L+++P ++ H L+  D+FL+ ASDGLW+ LSN+D V +V  H       
Sbjct: 378 FTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWH 437

Query: 304 ----------------------------PHSGSARKLIKVAL--LEAAKKREMRYSDLKK 333
                                           +A +LI+ A+   E  +    R + +  
Sbjct: 438 KTDLAQRPANLGLMQSLLLQRKASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLT 497

Query: 334 IDRGVRRHFHDDITVVVIFLDSNLV 358
           +   + R + DDITV V++ +S  +
Sbjct: 498 LPEDLARMYRDDITVTVVYFNSESI 522



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 18/61 (29%), Positives = 32/61 (51%), Gaps = 6/61 (9%)

Query: 53  ANNLLEDQSQIESGPLSFLDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKS 112
           AN+ +ED+     G  S L T   G   G++DGHGG   ++ + + LF ++      H++
Sbjct: 116 ANSPVEDRR----GVASCLQTN--GLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQT 169

Query: 113 M 113
           +
Sbjct: 170 L 170


>PDP1_HUMAN (Q9P0J1) [Pyruvate dehydrogenase
           [Lipoamide]]-phosphatase 1, mitochondrial precursor (EC
           3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase,
           catalytic subunit 1) (PDPC 1)
          Length = 538

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 85/325 (26%), Positives = 135/325 (41%), Gaps = 59/325 (18%)

Query: 19  DRKSSDVCGKKEGLL-----------WYKDAGQHLFGDYSMAVVQANNLLEDQSQIESG- 66
           DR+S+  C +  G+L           W +   + LF   + ++V    LLE ++ +ESG 
Sbjct: 125 DRRSAATCLQTRGMLLGVFDGHAGCAWSQAVSERLFYYIAGSLVPHETLLEIENAVESGR 184

Query: 67  ---PLSFLDTGPYGTFVG----------------VYDGHGGPETSRFICDHLFQHLKRFA 107
              P+      P   F                  + D + G  T   + + L    KR  
Sbjct: 185 ALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKR-- 242

Query: 108 TEHKSMSVEVIRKAYQATEEGFLGVVTKHWPMNPQIAAVGSCCLVGVICGGSLYIANLGD 167
                +  ++  +A       FL  +        ++A  G+   V  + G  L++AN GD
Sbjct: 243 -----LDNDISLEAQVGDPNSFLNYLVL------RVAFSGATACVAHVDGVDLHVANTGD 291

Query: 168 SRAVLGRAVRATGEVLAIQLSPEHNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQ 227
           SRA+LG      G   A+ LS +HN   E   + +   HP      V+K +  R+ GL+ 
Sbjct: 292 SRAMLG-VQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQD--RLLGLLM 348

Query: 228 ISRSIGDVYLKKA--------EFNREPL----YAKFRLRETFKTPILSSDPSISVHELQE 275
             R+ GDV  K +        E   + L    Y KF        P L+++P ++ H L+ 
Sbjct: 349 PFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRP 408

Query: 276 HDQFLIFASDGLWEHLSNQDAVDIV 300
            D+FL+ A+DGLWE +  QD V IV
Sbjct: 409 QDKFLVLATDGLWETMHRQDVVRIV 433


>PDP1_RAT (O88483) [Pyruvate dehydrogenase [Lipoamide]]-phosphatase
           1, mitochondrial precursor (EC 3.1.3.43) (PDP 1)
           (Pyruvate dehydrogenase phosphatase, catalytic subunit
           1) (PDPC 1)
          Length = 538

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 58/171 (33%), Positives = 86/171 (49%), Gaps = 15/171 (8%)

Query: 142 QIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAIESVRQE 201
           ++A  G+   V  + G  L++AN GDSRA+LG      G   A+ LS +HN   E   Q 
Sbjct: 266 RVAFSGATACVAHVDGVDLHVANTGDSRAMLG-VQEEDGSWSAVTLSNDHNAQNERELQR 324

Query: 202 MHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKA--------EFNREPL----YA 249
           +   HP +    V+K +  R+ GL+   R+ GDV  K +        E   + L    Y 
Sbjct: 325 LKLEHPKNEAKSVVKQD--RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYT 382

Query: 250 KFRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIV 300
           KF        P L+++P ++ H L+  D+FL+ A+DGLWE +  QD V IV
Sbjct: 383 KFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433


>PDP1_BOVIN (P35816) [Pyruvate dehydrogenase
           [Lipoamide]]-phosphatase 1, mitochondrial precursor (EC
           3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase,
           catalytic subunit 1) (PDPC 1)
          Length = 538

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 57/171 (33%), Positives = 87/171 (50%), Gaps = 15/171 (8%)

Query: 142 QIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAIESVRQE 201
           ++A  G+   V  + G  L++AN GDSRA+LG      G   A+ LS +HN   E   + 
Sbjct: 266 RVAFSGATACVAHVDGVDLHVANTGDSRAMLG-VQEEDGSWSAVTLSNDHNAQNEREVER 324

Query: 202 MHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKA--------EFNREPL----YA 249
           +   HP +    V+K +  R+ GL+   R+ GDV  K +        E   + L    Y 
Sbjct: 325 LKLEHPKNEAKSVVKQD--RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYT 382

Query: 250 KFRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIV 300
           KF     +  P L+++P ++ H L+  D+FL+ A+DGLWE +  QD V IV
Sbjct: 383 KFIPPNYYTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433


>P2C1_ARATH (P49597) Protein phosphatase 2C ABI1 (EC 3.1.3.16)
           (PP2C) (Abscisic acid-insensitive 1)
          Length = 434

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 78/287 (27%), Positives = 130/287 (45%), Gaps = 48/287 (16%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEV---IRKAYQATEEGFLGVVTK 135
           F GVYDGHGG + + +  + +   L     + K M  +    + K  +A    FL V ++
Sbjct: 172 FFGVYDGHGGSQVANYCRERMHLALAEEIAKEKPMLCDGDTWLEKWKKALFNSFLRVDSE 231

Query: 136 HWPMNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAI 195
              + P+   VGS  +V V+    +++AN GDSRAVL R   A      + LS +H    
Sbjct: 232 IESVAPE--TVGSTSVVAVVFPSHIFVANCGDSRAVLCRGKTA------LPLSVDHKPDR 283

Query: 196 ESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAKFRLRE 255
           E     + +         V++ N  RV G++ +SRSIGD YLK                 
Sbjct: 284 EDEAARIEAAGGK-----VIQWNGARVFGVLAMSRSIGDRYLK----------------- 321

Query: 256 TFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIV--------QNHPHSG 307
               P +  DP ++  +  + D  LI ASDG+W+ +++++A ++         + +  +G
Sbjct: 322 ----PSIIPDPEVTAVKRVKEDDCLILASDGVWDVMTDEEACEMARKRILLWHKKNAVAG 377

Query: 308 SARKLIKVALLEAAKKREMRYSD-LKKIDRGVRRHFHDDITVVVIFL 353
            A  L      E      M  ++ L K+   ++R   D+I+VVV+ L
Sbjct: 378 DASLLADERRKEGKDPAAMSAAEYLSKL--AIQRGSKDNISVVVVDL 422


>PDP2_RAT (O88484) [Pyruvate dehydrogenase [Lipoamide]]-phosphatase
           2, mitochondrial precursor (EC 3.1.3.43) (PDP 2)
           (Pyruvate dehydrogenase phosphatase, catalytic subunit
           2) (PDPC 2)
          Length = 530

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 53/274 (19%)

Query: 133 VTKHWPMNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHN 192
           VTK+  ++ Q+A  G+   +  + G  L+IAN GD RA+LG      G    + L+ +HN
Sbjct: 255 VTKN--LSLQVAFSGATACMAHVDGVHLHIANAGDCRAILG-VQGDNGAWSCLPLTCDHN 311

Query: 193 VAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAE----------F 242
              E+    +   HP+     ++  +  R+ G++   R+ GDV LK ++          F
Sbjct: 312 AWNEAELSRLKREHPESEDRTLIIDD--RLLGVLLPCRAFGDVQLKWSKELQRNVLERGF 369

Query: 243 NREPLYA-KFRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQ 301
           + E L   +F        P L++ P ++ H L+  D+FL+ ASDGLW+ L N+D V +V 
Sbjct: 370 DTEALNIYQFTPPHYHTPPYLTAKPEVTYHRLRPQDKFLVLASDGLWDMLDNEDVVRLVV 429

Query: 302 NH-----------------------------------PHSGSARKLIKVAL--LEAAKKR 324
            H                                       +A  LI+ A+   E  +  
Sbjct: 430 GHLSKVGHQKPALDQRPANLGHMQSLLLQRKASGLHAADQNAATHLIRHAIGSNEYGEME 489

Query: 325 EMRYSDLKKIDRGVRRHFHDDITVVVIFLDSNLV 358
             R + +  +   V R + DDITV+V+F +S  +
Sbjct: 490 PERLAAMLTLPEDVARMYRDDITVMVVFFNSESI 523



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 19/61 (31%), Positives = 33/61 (53%), Gaps = 6/61 (9%)

Query: 53  ANNLLEDQSQIESGPLSFLDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKS 112
           AN+ +ED+     G  S + T   GT  G++DGHGG   ++ + + LF ++      HK+
Sbjct: 117 ANSPVEDRQ----GVASCVQTR--GTVFGIFDGHGGHACAQAVSERLFYYMAVSLMSHKT 170

Query: 113 M 113
           +
Sbjct: 171 L 171


>FEM2_HUMAN (P49593) Ca(2+)/calmodulin-dependent protein kinase
           phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase)
           (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein
           phosphatase 1F)
          Length = 454

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 82/317 (25%), Positives = 139/317 (42%), Gaps = 62/317 (19%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVIRKAYQATEEGFLGVVTKHWP 138
           +  V+DGHGG + +R+   H+  +  R   E  +     +R+A++ T++ FL    +   
Sbjct: 193 YFAVFDGHGGVDAARYAAVHVHTNAAR-QPELPTDPEGALREAFRRTDQMFLRKAKRE-- 249

Query: 139 MNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAIESV 198
              Q    G C L   I G +L++A LGDS+ +L +     G+V  ++L   H    +  
Sbjct: 250 -RLQSGTTGVCAL---IAGATLHVAWLGDSQVILVQQ----GQV--VKLMEPHRPERQDE 299

Query: 199 RQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAKFRLRETFK 258
           +  + +L        V   + WRV G + +SR+IGDV+ K                    
Sbjct: 300 KARIEALGG-----FVSHMDCWRVNGTLAVSRAIGDVFQK-------------------- 334

Query: 259 TPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQNH--PHSGSARKLIKVA 316
            P +S +   +   L   + +L+ A DG ++ + +Q+ V +VQ+H     GS  ++ +  
Sbjct: 335 -PYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAE-E 392

Query: 317 LLEAAKKREMRYSDLKKIDRGVRRHFHDDITVVVIFL--DSNLVSRASTVTGPPVSLRGA 374
           L+ AA++R                  HD+ITV+V+FL     L+   +   G P    G 
Sbjct: 393 LVAAARERGS----------------HDNITVMVVFLRDPQELLEGGNQGEGDP-QAEGR 435

Query: 375 GVPLPSRSLAPMELPGP 391
              LPS SL   E   P
Sbjct: 436 RQDLPS-SLPEPETQAP 451


>P2C3_SCHPO (Q09173) Protein phosphatase 2C homolog 3 (EC 3.1.3.16)
           (PP2C-3)
          Length = 414

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 63/243 (25%), Positives = 114/243 (45%), Gaps = 37/243 (15%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVIRKAYQATEEGFLGVVTKHWP 138
           F  VYDGHGG + +++   +L Q L++     K   V  ++ ++   ++  L        
Sbjct: 57  FFAVYDGHGGDKVAKWCGSNLPQILEKNPDFQKGDFVNALKSSFLNADKAILD------- 109

Query: 139 MNPQIAAVGSCCLVGVIC--GGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAIE 196
            + Q     S C   V+   G  LY AN GDSR VLG       + +A  LS +H  + E
Sbjct: 110 -DDQFHTDPSGCTATVVLRVGNKLYCANAGDSRTVLG------SKGIAKPLSADHKPSNE 162

Query: 197 SVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAKFRLRET 256
           + +  + +             +  RV G + +SR+IGD   K +  N EP          
Sbjct: 163 AEKARICAAGGFV--------DFGRVNGNLALSRAIGDFEFKNS--NLEP---------- 202

Query: 257 FKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQNHPHSGSARKLIKVA 316
            +  I+++ P + VHE+ + D+F++ A DG+W+  ++Q  ++ V+    +G++ + I   
Sbjct: 203 -EKQIVTALPDVVVHEITDDDEFVVLACDGIWDCKTSQQVIEFVRRGIVAGTSLEKIAEN 261

Query: 317 LLE 319
           L++
Sbjct: 262 LMD 264


>P2C2_SCHPO (Q09172) Protein phosphatase 2C homolog 2 (EC 3.1.3.16)
           (PP2C-2)
          Length = 370

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 62/237 (26%), Positives = 106/237 (44%), Gaps = 34/237 (14%)

Query: 68  LSFLDTG---PYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVIRKAYQA 124
           L+F D+    P  +F GV+DGHGG   +++   HL   +K   +  K    E ++  + A
Sbjct: 44  LNFTDSNSSNPPTSFFGVFDGHGGDRVAKYCRQHLPDIIKSQPSFWKGNYDEALKSGFLA 103

Query: 125 TEEGFLGVVTKHWPMNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLA 184
            +   +    +    +P      +  +V       +Y AN GDSR VLGR  + T E L+
Sbjct: 104 ADNALMQ--DRDMQEDPSGCTATTALIVD---HQVIYCANAGDSRTVLGR--KGTAEPLS 156

Query: 185 IQLSPEHNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNR 244
               P ++V    +      +            +  RV G + +SR+IGD   KK + + 
Sbjct: 157 FDHKPNNDVEKARITAAGGFI------------DFGRVNGSLALSRAIGDFEYKK-DSSL 203

Query: 245 EPLYAKFRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQ 301
            P           +  I+++ P + +H +   D+FLI A DG+W+  S+Q  V+ V+
Sbjct: 204 PP-----------EKQIVTAFPDVVIHNIDPDDEFLILACDGIWDCKSSQQVVEFVR 249


>P2C2_ARATH (O04719) Protein phosphatase 2C ABI2 (EC 3.1.3.16)
           (PP2C) (Abscisic acid-insensitive 2)
          Length = 423

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 80/290 (27%), Positives = 127/290 (43%), Gaps = 53/290 (18%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVI---RKAYQATEEGFLGVVTK 135
           F GVYDGHGG + + +  + +   L     + K    +      K  +A    F+ V ++
Sbjct: 160 FFGVYDGHGGSQVANYCRERMHLALTEEIVKEKPEFCDGDTWQEKWKKALFNSFMRVDSE 219

Query: 136 HWPMNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVAI 195
              +      VGS  +V V+    +++AN GDSRAVL R    T   L++   P+ +   
Sbjct: 220 IETVAHAPETVGSTSVVAVVFPTHIFVANCGDSRAVLCRG--KTPLALSVDHKPDRDD-- 275

Query: 196 ESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAKFRLRE 255
           E+ R E            V++ N  RV G++ +SRSIGD YLK                 
Sbjct: 276 EAARIEAAGGK-------VIRWNGARVFGVLAMSRSIGDRYLK----------------- 311

Query: 256 TFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQNHP---HSGSARKL 312
               P +  DP ++     + D  LI ASDGLW+ ++N++  D+ +      H  +A  +
Sbjct: 312 ----PSVIPDPEVTSVRRVKEDDCLILASDGLWDVMTNEEVCDLARKRILLWHKKNA--M 365

Query: 313 IKVALLEAAKKRE---------MRYSDLKKIDRGVRRHFHDDITVVVIFL 353
              ALL A K+ E           Y     + +G +    D+I+VVV+ L
Sbjct: 366 AGEALLPAEKRGEGKDPAAMSAAEYLSKMALQKGSK----DNISVVVVDL 411


>P2C5_YEAST (Q12511) Protein phosphatase 2C homolog 5 (EC 3.1.3.16)
           (PP2C-5)
          Length = 572

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 91/340 (26%), Positives = 150/340 (43%), Gaps = 68/340 (20%)

Query: 46  YSMAVVQANNLLEDQS-------QIESGPLSFLDTGPYGTFVGVYDGHGGPETS------ 92
           Y +A + +N+ +ED          IES     ++   Y  F G++DGHGGP TS      
Sbjct: 154 YDVAQLPSNHPIEDDHVEQIITIPIESEDGKSIEKDLY--FFGIFDGHGGPFTSEKLSKD 211

Query: 93  --RFICDHLFQHLKRFATEHKSMSVEVIRKAYQATEEGFL----GVVTKHW------PMN 140
             R++   L Q   +  T   S   ++I  A     +GFL     +V + +      P N
Sbjct: 212 LVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAIS---KGFLKLDNDLVIESFRKLFQDPNN 268

Query: 141 PQIAAV-----GSCCLVGVI--CGGSLYIANLGDSRAV---LGRAVRATGEVLAIQLSPE 190
             IA       GSC L+ +       L +A  GDSRA+   L      T + L+   + +
Sbjct: 269 TNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGLDNEGNWTVKSLSTDQTGD 328

Query: 191 HNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPL--- 247
           +   +  +R+E    HP +P ++       R+ G +Q SR+ GD   K  E + +PL   
Sbjct: 329 NLDEVRRIRKE----HPGEPNVI----RNGRILGSLQPSRAFGDYRYKIKEVDGKPLSDL 380

Query: 248 --YAKFRLRET---FKTP-ILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQ 301
              AK   R     FKTP  ++++P I+  ++ E+ +F++  SDGL+E L+N++   +V 
Sbjct: 381 PEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASLVI 440

Query: 302 N-----------HPHSGSARKLIKVALLEAAKKREMRYSD 330
                           G   K+I V+  + A++   RY D
Sbjct: 441 RWMDKNMNLAPVKAEPGKLPKVIDVSEDKEAQRPAFRYKD 480


>P2CD_HUMAN (O15297) Protein phosphatase 2C delta isoform (EC
           3.1.3.16) (PP2C-delta) (p53-induced protein phosphatase
           1) (Protein phosphatase magnesium-dependent 1 delta)
          Length = 605

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 70/292 (23%), Positives = 123/292 (41%), Gaps = 56/292 (19%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKR---FATEHKSMSVEVIRKAYQATEEGFLGVVTK 135
           F  V DGHGG E ++F  +HL+  +K+   F +   +     IRK + A        + +
Sbjct: 100 FFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAE 159

Query: 136 HWP--MNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGE-VLAIQLSPEHN 192
            WP  M    +  G+   V +I G  +Y+A++GDS  VLG       + V A++++ +H 
Sbjct: 160 -WPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHK 218

Query: 193 VAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGL-----------------IQISRSIGDV 235
             +   R+ +  L         +   VW+   L                 + ++R++GD+
Sbjct: 219 PELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDL 278

Query: 236 Y---LKKAEFNREPLYAKFRLRETFKTPILSSDPSISVHEL--QEHDQFLIFASDGLWEH 290
           +       EF                  ++S +P  SVH L  Q+H +++I  SDGLW  
Sbjct: 279 WSYDFFSGEF------------------VVSPEPDTSVHTLDPQKH-KYIILGSDGLWNM 319

Query: 291 LSNQDAVDIVQNH--------PHSGSARKLIKVALLEAAKKREMRYSDLKKI 334
           +  QDA+ + Q+          H  S  K++    L   ++R +R  +   I
Sbjct: 320 IPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAI 371


>P2CD_MOUSE (Q9QZ67) Protein phosphatase 2C delta isoform (EC
           3.1.3.16) (PP2C-delta) (p53-induced protein phosphatase
           1) (Protein phosphatase magnesium-dependent 1 delta)
          Length = 598

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 61/248 (24%), Positives = 109/248 (43%), Gaps = 40/248 (16%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKR---FATEHKSMSVEVIRKAYQATEEGFLGVVTK 135
           F  V DGHGG E ++F  +HL+  +K+   F +   +     IRK + A        + +
Sbjct: 93  FFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAE 152

Query: 136 HWP--MNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGE-VLAIQLSPEHN 192
            WP  M    +  G+   V +I G  +Y+A++GDS  VLG       + V A++++ +H 
Sbjct: 153 -WPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHK 211

Query: 193 VAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGL-----------------IQISRSIGDV 235
             +   R+ +  L         +   VW+   L                 + ++R++GD+
Sbjct: 212 PELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVIDQIPFLAVARALGDL 271

Query: 236 YLKKAEFNREPLYAKFRLRETFKTPILSSDPSISVHELQ-EHDQFLIFASDGLWEHLSNQ 294
           +      + +    KF         ++S +P  SVH L     +++I  SDGLW  +  Q
Sbjct: 272 W------SYDFFSGKF---------VVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQ 316

Query: 295 DAVDIVQN 302
           DA+ + Q+
Sbjct: 317 DAISMCQD 324


>FEM2_RAT (Q9WVR7) Ca(2+)/calmodulin-dependent protein kinase
           phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase)
           (CaMKPase) (Partner of PIX 2) (Protein phosphatase 1F)
          Length = 450

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 71/289 (24%), Positives = 123/289 (41%), Gaps = 66/289 (22%)

Query: 71  LDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVIRKAYQATEEGFL 130
           L    +  +  V+DGHGG + +R+   H+  +      E  +     +++A++ T++ FL
Sbjct: 181 LSDSVHRAYFAVFDGHGGVDAARYASVHVHTNASH-QPELLTDPAAALKEAFRHTDQMFL 239

Query: 131 GVVTKHWPMNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPE 190
               +      Q    G C L   I G +L++A LGDS+ +L +     G+V  ++L   
Sbjct: 240 QKAKRE---RLQSGTTGVCAL---ITGAALHVAWLGDSQVILVQQ----GQV--VKLMEP 287

Query: 191 HNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAK 250
           H    +  +  + +L        V   + WRV G + +SR+IGDV               
Sbjct: 288 HKPERQDEKSRIEALGG-----FVSLMDCWRVNGTLAVSRAIGDV--------------- 327

Query: 251 FRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQNH--PHSGS 308
                 F+ P +S +   +  EL   + +L+ A DG ++ + + +   +V  H     GS
Sbjct: 328 ------FQKPYVSGEADAASRELTGLEDYLLLACDGFFDVVPHHEIPGLVHGHLLRQKGS 381

Query: 309 ----ARKLIKVALLEAAKKREMRYSDLKKIDRGVRRHFHDDITVVVIFL 353
               A +L+ VA                  DRG     HD+ITV+V+FL
Sbjct: 382 GMHVAEELVAVAR-----------------DRG----SHDNITVMVVFL 409


>P2CA_MOUSE (P49443) Protein phosphatase 2C alpha isoform (EC
           3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
          Length = 382

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 59/250 (23%), Positives = 105/250 (41%), Gaps = 33/250 (13%)

Query: 57  LEDQSQIESGPLSFLDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVE 116
           +ED      G  S L+T    +F  VYDGH G + +++ C+HL  H+        S    
Sbjct: 36  MEDAHTAVIGLPSGLETW---SFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFRGSAGAP 92

Query: 117 VIRKAYQATEEGFLGVVTKHWPMNPQIAAV---GSCCLVGVICGGSLYIANLGDSRAVLG 173
            +         GFL +      M+ +       GS  +  +I     Y  N GDSR +L 
Sbjct: 93  SVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLC 152

Query: 174 RAVRATGEVLAIQLSPEHNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIG 233
           R  +           P + +  E ++    S+             + RV G + +SR++G
Sbjct: 153 RNRKV--HFFTQDHKPSNPLEKERIQNAGGSV------------MIQRVNGSLAVSRALG 198

Query: 234 DVYLKKAEFNREPLYAKFRLRETFKTPILSSDPSI-SVHELQEHDQFLIFASDGLWEHLS 292
           D       F+ + ++ K    +     ++S +P +  +   +E DQF+I A DG+W+ + 
Sbjct: 199 D-------FDYKCVHGKGPTEQ-----LVSPEPEVHDIERSEEDDQFIILACDGIWDVMG 246

Query: 293 NQDAVDIVQN 302
           N++  D V++
Sbjct: 247 NEELCDFVRS 256


>P2C4_ARATH (P49598) Protein phosphatase 2C (EC 3.1.3.16) (PP2C)
          Length = 399

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 80/313 (25%), Positives = 121/313 (38%), Gaps = 78/313 (24%)

Query: 79  FVGVYDGHGGPETSRFICDHLFQHLKR-------------FATEHKSMSVEVIRKAYQAT 125
           F GV+DGHG    +    + L   +K+                  + M  EV ++     
Sbjct: 137 FYGVFDGHGCSHVAEKCRERLHDIVKKEVEVMASDEWTETMVKSFQKMDKEVSQRECNLV 196

Query: 126 EEGFLGVVTKHWP---MNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEV 182
             G    +         +PQ  AVGS  +V V+    + ++N GDSRAVL R        
Sbjct: 197 VNGATRSMKNSCRCELQSPQCDAVGSTAVVSVVTPEKIIVSNCGDSRAVLCR------NG 250

Query: 183 LAIQLSPEHNVAIESVRQEMHSLHPDDPKIVVLKHNV------W---RVKGLIQISRSIG 233
           +AI LS +H               PD P  ++           W   RV G++ +SR+IG
Sbjct: 251 VAIPLSVDHK--------------PDRPDELIRIQQAGGRVIYWDGARVLGVLAMSRAIG 296

Query: 234 DVYLKKAEFNREPLYAKFRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSN 293
           D YLK                     P +  DP ++V +  + D+ LI ASDGLW     
Sbjct: 297 DNYLK---------------------PYVIPDPEVTVTDRTDEDECLILASDGLW----- 330

Query: 294 QDAVDIVQNHPHSGSARKLIKVALL---EAAKKREMRYSDLKKIDRGVRRHFHDDITVVV 350
               D+V N    G AR  ++ A       A       + L      + R   D+++VVV
Sbjct: 331 ----DVVPNETACGVARMCLRGAGAGDDSDAAHNACSDAALLLTKLALARQSSDNVSVVV 386

Query: 351 IFLDSNLVSRAST 363
           + L     ++AS+
Sbjct: 387 VDLRKRRNNQASS 399


>P2CA_RAT (P20650) Protein phosphatase 2C alpha isoform (EC
           3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
          Length = 382

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 59/250 (23%), Positives = 105/250 (41%), Gaps = 33/250 (13%)

Query: 57  LEDQSQIESGPLSFLDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVE 116
           +ED      G  S L+T    +F  VYDGH G + +++ C+HL  H+        S    
Sbjct: 36  MEDAHTAVIGLPSGLETW---SFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAP 92

Query: 117 VIRKAYQATEEGFLGVVTKHWPMNPQIAAV---GSCCLVGVICGGSLYIANLGDSRAVLG 173
            +         GFL +      M+ +       GS  +  +I     Y  N GDSR +L 
Sbjct: 93  SVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLC 152

Query: 174 RAVRATGEVLAIQLSPEHNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIG 233
           R  +           P + +  E ++    S+             + RV G + +SR++G
Sbjct: 153 RNRKV--HFFTQDHKPSNPLEKERIQNAGGSV------------MIQRVNGSLAVSRALG 198

Query: 234 DVYLKKAEFNREPLYAKFRLRETFKTPILSSDPSI-SVHELQEHDQFLIFASDGLWEHLS 292
           D       F+ + ++ K    +     ++S +P +  +   +E DQF+I A DG+W+ + 
Sbjct: 199 D-------FDYKCVHGKGPTEQ-----LVSPEPEVHDIERSEEDDQFIILACDGIWDVMG 246

Query: 293 NQDAVDIVQN 302
           N++  D V++
Sbjct: 247 NEELCDFVRS 256


>P2CA_RABIT (P35814) Protein phosphatase 2C alpha isoform (EC
           3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
          Length = 382

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 59/250 (23%), Positives = 105/250 (41%), Gaps = 33/250 (13%)

Query: 57  LEDQSQIESGPLSFLDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVE 116
           +ED      G  S L+T    +F  VYDGH G + +++ C+HL  H+        S    
Sbjct: 36  MEDAHTAVIGLPSGLETW---SFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAP 92

Query: 117 VIRKAYQATEEGFLGVVTKHWPMNPQIAAV---GSCCLVGVICGGSLYIANLGDSRAVLG 173
            +         GFL +      M+ +       GS  +  +I     Y  N GDSR +L 
Sbjct: 93  SVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLC 152

Query: 174 RAVRATGEVLAIQLSPEHNVAIESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIG 233
           R  +           P + +  E ++    S+             + RV G + +SR++G
Sbjct: 153 RNRKV--HFFTQDHKPSNPLEKERIQNAGGSV------------MIQRVNGSLAVSRALG 198

Query: 234 DVYLKKAEFNREPLYAKFRLRETFKTPILSSDPSI-SVHELQEHDQFLIFASDGLWEHLS 292
           D       F+ + ++ K    +     ++S +P +  +   +E DQF+I A DG+W+ + 
Sbjct: 199 D-------FDYKCVHGKGPTEQ-----LVSPEPEVHDIERSEEDDQFIILACDGIWDVMG 246

Query: 293 NQDAVDIVQN 302
           N++  D V++
Sbjct: 247 NEELCDFVRS 256


>P2CA_HUMAN (P35813) Protein phosphatase 2C alpha isoform (EC
           3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A)
          Length = 382

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 53/229 (23%), Positives = 97/229 (42%), Gaps = 30/229 (13%)

Query: 78  TFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVIRKAYQATEEGFLGVVTKHW 137
           +F  VYDGH G + +++ C+HL  H+        S     +         GFL +     
Sbjct: 54  SFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMR 113

Query: 138 PMNPQIAAV---GSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSPEHNVA 194
            M+ +       GS  +  +I     Y  N GDSR +L R  +           P + + 
Sbjct: 114 VMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKV--HFFTQDHKPSNPLE 171

Query: 195 IESVRQEMHSLHPDDPKIVVLKHNVWRVKGLIQISRSIGDVYLKKAEFNREPLYAKFRLR 254
            E ++    S+             + RV G + +SR++GD       F+ + ++ K    
Sbjct: 172 KERIQNAGGSV------------MIQRVNGSLAVSRALGD-------FDYKCVHGKGPTE 212

Query: 255 ETFKTPILSSDPSI-SVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQN 302
           +     ++S +P +  +   +E DQF+I A DG+W+ + N++  D V++
Sbjct: 213 Q-----LVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRS 256


>P2C2_CAEEL (P49596) Probable protein phosphatase 2C T23F11.1 (EC
           3.1.3.16) (PP2C)
          Length = 356

 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 62/236 (26%), Positives = 103/236 (43%), Gaps = 42/236 (17%)

Query: 71  LDTGPYGTFVGVYDGHGGPETSRFICDHLFQHLKRFATEHKSMSVEVIRKAYQATEEGFL 130
           L   P   F  VYDGHGG + S++   +L  H K  A +  S          +A E+GFL
Sbjct: 46  LPDDPKCAFFAVYDGHGGSKVSQYSGINL--HKKVVAQKEFSEG-----NMKEAIEKGFL 98

Query: 131 GVVTK-HWPMNPQIAAVGSCCLVGVICGGSLYIANLGDSRAVLGRAVRATGEVLAIQLSP 189
            +  +       +    G+  +V +I  G +Y  N GDSRAV        GE  A  LS 
Sbjct: 99  ELDQQMRVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSS----VVGE--ARPLSF 152

Query: 190 EHNVAIESVRQEMHSLHPDDPKIVVLKHNVW----RVKGLIQISRSIGDVYLKKAEFNRE 245
           +H  + E+  +             ++    W    RV G + +SR++GD   K  +    
Sbjct: 153 DHKPSHETEARR------------IIAAGGWVEFNRVNGNLALSRALGDFAFKNCD---- 196

Query: 246 PLYAKFRLRETFKTPILSSDPSISVHELQEHDQFLIFASDGLWEHLSNQDAVDIVQ 301
                    +  +  I+++ P +   +L    +F++ A DG+W+ ++NQ+ VD V+
Sbjct: 197 --------TKPAEEQIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVR 244


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.320    0.137    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,376,703
Number of Sequences: 164201
Number of extensions: 1948334
Number of successful extensions: 4988
Number of sequences better than 10.0: 56
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 4817
Number of HSP's gapped (non-prelim): 93
length of query: 392
length of database: 59,974,054
effective HSP length: 112
effective length of query: 280
effective length of database: 41,583,542
effective search space: 11643391760
effective search space used: 11643391760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)