BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC149307.9 - phase: 0
(271 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.1.... 336 4e-92
ST6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC... 335 5e-92
STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.... 335 9e-92
STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.1.... 333 3e-91
STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.1.37... 333 3e-91
AURB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.1.3... 324 1e-88
AURB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.1... 322 8e-88
AURB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.1... 317 2e-86
AURC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.1... 316 3e-86
AURC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.1... 307 2e-83
ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7... 300 3e-81
IPL1_YEAST (P38991) Serine/threonine-protein kinase IPL1 (EC 2.7... 270 3e-72
KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7... 192 7e-49
PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7... 190 4e-48
KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7... 190 4e-48
AURB_PIG (Q9N0X0) Serine/threonine-protein kinase 12 (EC 2.7.1.3... 186 4e-47
KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7... 186 7e-47
PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7... 185 9e-47
KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subu... 184 2e-46
PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7... 182 1e-45
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.1.37)
(Aurora-family kinase 1) (Aurora/IPL1-related kinase 1)
(Ipl1- and aurora-related kinase 1) (Aurora-A)
(Serine/threonine kinase Ayk1)
Length = 395
Score = 336 bits (861), Expect = 4e-92
Identities = 158/266 (59%), Positives = 205/266 (76%), Gaps = 3/266 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
R+W++ DF+IG+PLGKGKFG VY+ARE +SKF++ALKV+FK QLEK HQLRRE+EIQ
Sbjct: 117 RQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQ 176
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+HPN+L LYG+FHD+ RV+LILEYA G +Y+EL K F E++ ATYI L AL+
Sbjct: 177 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 236
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQS-KDKRKTMCGTLDYLAPEMVENKT 181
YCH VIHRDIKPENLLL G LKIADFGWSV + +R TMCGTLDYL PEM+E +
Sbjct: 237 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRM 296
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
HD VD W+LG+LCYEFL G+PPFEA + +T+ RI +V+ +FP V+ A++LISRL
Sbjct: 297 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP--DFVTEGARDLISRL 354
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNANR 267
L ++S+RL+L +++EHPWI N+++
Sbjct: 355 LKHNASQRLTLAEVLEHPWIKANSSK 380
>ST6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC
2.7.1.37) (p46XlEg22)
Length = 408
Score = 335 bits (860), Expect = 5e-92
Identities = 156/266 (58%), Positives = 203/266 (75%), Gaps = 3/266 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
++W + DFEIG+PLGKGKFG VY+ARE +SKF++ALKV+FK QLEK HQLRRE+EIQ
Sbjct: 133 KQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQ 192
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+HPN+L LYG+FHD+ RV+LIL+YA GEL++EL K F ++++A YI L EAL
Sbjct: 193 SHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEALL 252
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQS-KDKRKTMCGTLDYLAPEMVENKT 181
YCH VIHRDIKPENLLL G LKIADFGWSV + +R T+CGTLDYL PEM+E +
Sbjct: 253 YCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 312
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
HD VD W+LG+LCYEFL G PPFE ++ +T+ RI KV+ +P P VS +AK+L+S+L
Sbjct: 313 HDEKVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISKVEFQYP--PYVSEEAKDLVSKL 370
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNANR 267
L + + RL L+ ++EHPWI+KN+ +
Sbjct: 371 LKHNPNHRLPLKGVLEHPWIVKNSQQ 396
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC
2.7.1.37) (pEg2) (p46Eg265)
Length = 407
Score = 335 bits (858), Expect = 9e-92
Identities = 156/264 (59%), Positives = 202/264 (76%), Gaps = 3/264 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
++W + DFEIG+PLGKGKFG VY+ARE +SKF++ALKV+FK QLEK HQLRRE+EIQ
Sbjct: 133 KQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQ 192
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+HPN+L LYG+FHD+ RV+LIL+YA GEL++EL K F ++++A YI L EAL
Sbjct: 193 SHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEALL 252
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQS-KDKRKTMCGTLDYLAPEMVENKT 181
YCH VIHRDIKPENLLL G LKIADFGWSV + +R T+CGTLDYL PEM+E +
Sbjct: 253 YCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 312
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
HD VD W+LG+LCYEFL G PPFE ++ +T+ RI KV+ +P P VS +A++L+S+L
Sbjct: 313 HDETVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISKVEFQYP--PYVSEEARDLVSKL 370
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNA 265
L + + RL L+ ++EHPWIIKN+
Sbjct: 371 LKHNPNHRLPLKGVLEHPWIIKNS 394
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.1.37)
(Serine/threonine kinase 15) (Aurora/IPL1-related kinase
1) (Aurora-related kinase 1) (hARK1) (Aurora-A)
(Breast-tumor-amplified kinase)
Length = 403
Score = 333 bits (854), Expect = 3e-91
Identities = 158/270 (58%), Positives = 204/270 (75%), Gaps = 3/270 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
R+W++ DFEIG+PLGKGKFG VY+ARE +SKF++ALKV+FK QLEK HQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+HPN+L LYG+FHD+ RV+LILEYA G +Y+EL K F E++ ATYI L AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQS-KDKRKTMCGTLDYLAPEMVENKT 181
YCH VIHRDIKPENLLL G LKIADFGWSV + +R T+CGTLDYL PEM+E +
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
HD VD W+LG+LCYEFL G PPFEA + +T++RI +V+ +FP V+ A++LISRL
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFP--DFVTEGARDLISRL 363
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNANRMGVC 271
L + S+R L++++EHPWI N+++ C
Sbjct: 364 LKHNPSQRPMLREVLEHPWITANSSKPSNC 393
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.1.37)
(Aurora-A) (ratAurA)
Length = 397
Score = 333 bits (853), Expect = 3e-91
Identities = 157/266 (59%), Positives = 204/266 (76%), Gaps = 3/266 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
R+W++ DF+IG+PLGKGKFG VY+ARE +SKF++ALKV+FK QLEK HQLRRE+EIQ
Sbjct: 119 RQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQ 178
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+HPN+L LYG+FHD+ RV+LILEYA G +Y+EL K F E++ ATYI L AL+
Sbjct: 179 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 238
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQS-KDKRKTMCGTLDYLAPEMVENKT 181
YCH VIHRDIKPENLLL G LKIADFGWSV + +R T+CGTLDY PEM+E +
Sbjct: 239 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYQPPEMIEGRM 298
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
HD VD W+LG+LCYEFL G+PPFEA + +T+ RI +V+ +FP V+ A++LISRL
Sbjct: 299 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP--DFVTEGARDLISRL 356
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNANR 267
L +SS+RL+L +++EHPWI N+++
Sbjct: 357 LKHNSSQRLTLAEVLEHPWIKANSSK 382
>AURB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.1.37)
(Aurora- and Ipl1-like midbody-associated protein 1)
(AIM-1) (Aurora-B)
Length = 343
Score = 324 bits (831), Expect = 1e-88
Identities = 155/265 (58%), Positives = 203/265 (76%), Gaps = 3/265 (1%)
Query: 5 WSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQIS 64
++I++FEIG+PLGKGKFG VY+ARE KS+F+VALK++FK Q+EK HQLRRE+EIQ
Sbjct: 75 FTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAH 134
Query: 65 LKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTYC 124
LKHPN+L LY +F+D +R++LILEYA GELYKEL K G F E++ AT + L++AL YC
Sbjct: 135 LKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSGTFDEQRTATIMEELSDALMYC 194
Query: 125 HENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKD-KRKTMCGTLDYLAPEMVENKTHD 183
H+ VIHRDIKPENLLL +G LKIADFGWSV + +RKTMCGTLDYL PEM+E + H+
Sbjct: 195 HKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN 254
Query: 184 YAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLV 243
VD W +G+LCYE + G PPFE+ S ++T+ RI KVDL FP S + AK+LIS+LL
Sbjct: 255 EMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSS--MPLGAKDLISKLLK 312
Query: 244 KDSSRRLSLQKIMEHPWIIKNANRM 268
+ S+RL L+++ HPW+ N+ R+
Sbjct: 313 HNPSQRLPLEQVSAHPWVRANSRRV 337
>AURB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC
2.7.1.37) (Aurora-related kinase 2)
(Serine/threonine-protein kinase 5) (STK-1) (Aurora-B)
Length = 345
Score = 322 bits (824), Expect = 8e-88
Identities = 155/265 (58%), Positives = 202/265 (75%), Gaps = 3/265 (1%)
Query: 5 WSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQIS 64
++I++FEIG+PLGKGKFG VY+ARE KS+F+VALK++FK Q+EK HQLRRE+EIQ
Sbjct: 77 FTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAH 136
Query: 65 LKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTYC 124
LKHPN+L LY +F+D +R++LILEYA GELYKEL K F E++ AT + L++ALTYC
Sbjct: 137 LKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELSDALTYC 196
Query: 125 HENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKD-KRKTMCGTLDYLAPEMVENKTHD 183
H+ VIHRDIKPENLLL +G LKIADFGWSV + +RKTMCGTLDYL PEM+E + H+
Sbjct: 197 HKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN 256
Query: 184 YAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLV 243
VD W +G+LCYE + G PPFE+ S ++T+ RI KVDL FP S V S A++LIS+LL
Sbjct: 257 EMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVDLKFPSS--VPSGAQDLISKLLK 314
Query: 244 KDSSRRLSLQKIMEHPWIIKNANRM 268
+ +RL L ++ HPW+ N+ R+
Sbjct: 315 HNPWQRLPLAEVAAHPWVRANSRRV 339
>AURB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC
2.7.1.37) (Aurora- and Ipl1-like midbody-associated
protein 1) (AIM-1) (Aurora/IPL1-related kinase 2)
(Aurora-related kinase 2) (STK-1) (Aurora-B)
Length = 344
Score = 317 bits (813), Expect = 2e-86
Identities = 157/269 (58%), Positives = 197/269 (72%), Gaps = 3/269 (1%)
Query: 1 MDREWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREME 60
+ R ++I+DFEIG+PLGKGKFG VY+ARE KS F+VALKV+FK Q+EK HQLRRE+E
Sbjct: 68 LTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIE 127
Query: 61 IQISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEA 120
IQ L HPN+L LY +F+D R++LILEYA GELYKEL K F E++ AT + L +A
Sbjct: 128 IQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADA 187
Query: 121 LTYCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKD-KRKTMCGTLDYLAPEMVEN 179
L YCH VIHRDIKPENLLL +G LKIADFGWSV + +RKTMCGTLDYL PEM+E
Sbjct: 188 LMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEG 247
Query: 180 KTHDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLIS 239
+ H+ VD W +G+LCYE L G PPFE+ S +T+ RI KVDL FP S V + A++LIS
Sbjct: 248 RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPAS--VPTGAQDLIS 305
Query: 240 RLLVKDSSRRLSLQKIMEHPWIIKNANRM 268
+LL + S RL L ++ HPW+ N+ R+
Sbjct: 306 KLLRHNPSERLPLAQVSAHPWVRANSRRV 334
>AURC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC
2.7.1.37) (Aurora/Ipl1/Eg2 protein 2)
(Aurora/Ipl1-related kinase 3) (Aurora-C)
Length = 309
Score = 316 bits (810), Expect = 3e-86
Identities = 155/267 (58%), Positives = 197/267 (73%), Gaps = 3/267 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
R +++DFEIG+PLGKGKFG VY+AR +S F+VALKV+FK Q+EK HQLRRE+EIQ
Sbjct: 36 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 95
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+HPN+L LY +FHD+ RV+LILEYA GELYKEL K E++ AT I L +ALT
Sbjct: 96 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 155
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKD-KRKTMCGTLDYLAPEMVENKT 181
YCH+ VIHRDIKPENLLL G +KIADFGWSV + +RKTMCGTLDYL PEM+E +T
Sbjct: 156 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 215
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
+D VD W +G+LCYE L G PPFE+ S ++T+ RI KVD+ FP S + A++LISRL
Sbjct: 216 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLS--MPLGARDLISRL 273
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNANRM 268
L RL L +I++HPW+ ++ R+
Sbjct: 274 LRYQPLERLPLAQILKHPWVQAHSRRV 300
>AURC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC
2.7.1.37) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C)
Length = 282
Score = 307 bits (787), Expect = 2e-83
Identities = 146/267 (54%), Positives = 200/267 (74%), Gaps = 3/267 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
+ ++INDFEIG+PLG+GKFGRVY+AR ++ F+VALKV+FK ++EK HQLRRE+EIQ
Sbjct: 9 KHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQ 68
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
L+H N+L LY +F+D R++LILEYA GELYKEL + +++ AT I L++ALT
Sbjct: 69 AHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALT 128
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKD-KRKTMCGTLDYLAPEMVENKT 181
YCHE VIHRDIKPENLLL G +KI+DFGWSV + +RKTMCGTLDYL PEM+ K
Sbjct: 129 YCHEKKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKP 188
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRL 241
++ VD W +G+LCYE L G PPFE+ + ++T+ RI++VD FP S V + A++LIS+L
Sbjct: 189 YNEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQVDFKFPSS--VPAGAQDLISKL 246
Query: 242 LVKDSSRRLSLQKIMEHPWIIKNANRM 268
L S RLSL ++++HPW+ +++ R+
Sbjct: 247 LRYHPSERLSLAQVLKHPWVREHSRRV 273
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC
2.7.1.37) (Aurora-related kinase 1)
Length = 355
Score = 300 bits (767), Expect = 3e-81
Identities = 147/263 (55%), Positives = 194/263 (72%), Gaps = 4/263 (1%)
Query: 3 REWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQ 62
RE+ I FEIGKPLGKGKFGRVY+A+E K+ F+VALK + K +L + K Q+RRE+EIQ
Sbjct: 82 REFHIGMFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQ 141
Query: 63 ISLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALT 122
+L+H N+L LYG FHD +R++LILE+A GELY+ L + FSE+ A+ YI + AL+
Sbjct: 142 SNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALS 201
Query: 123 YCHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQS-KDKRKTMCGTLDYLAPEMVENKT 181
Y H+ HVIHRDIKPEN+LL +G +K++DFGWSV + ++R T+CGTLDYL PEMVE K
Sbjct: 202 YLHKKHVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRTTLCGTLDYLPPEMVEGKE 261
Query: 182 HDYAVDNWTLGILCYEFLYGVPPFEAES-QADTFERIKKVDLSFPPSPLVSSDAKNLISR 240
H VD W+LG+L YEFL G PPFE S + T++RI KVDL P V DA++LISR
Sbjct: 262 HTEKVDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVDLKIP--SFVPPDARDLISR 319
Query: 241 LLVKDSSRRLSLQKIMEHPWIIK 263
LL + +R+SL+++M HPWI+K
Sbjct: 320 LLQHNPEKRMSLEQVMRHPWIVK 342
>IPL1_YEAST (P38991) Serine/threonine-protein kinase IPL1 (EC
2.7.1.37)
Length = 367
Score = 270 bits (690), Expect = 3e-72
Identities = 125/261 (47%), Positives = 182/261 (68%), Gaps = 4/261 (1%)
Query: 6 SINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQISL 65
S++DFE+GK LGKGKFG+VY R + ++ ALKV+ KE++ KY Q RRE+EIQ SL
Sbjct: 100 SLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSL 159
Query: 66 KHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTYCH 125
HPN+ YG+FHD +RV+L++EY NGE+YK L G F++ A+ YI + AL Y H
Sbjct: 160 NHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMH 219
Query: 126 ENHVIHRDIKPENLLLDHEGRLKIADFGWSV--QSKDKRKTMCGTLDYLAPEMVENKTHD 183
+ ++IHRDIKPEN+L+ +K+ DFGWS+ +++RKT+CGT+DYL+PEMVE++ +D
Sbjct: 220 KKNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYD 279
Query: 184 YAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLV 243
+ +D W LG+L +E L G PPFE E + T++RI +D+ P + +S DA++LI +LL
Sbjct: 280 HTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSN--ISQDAQDLILKLLK 337
Query: 244 KDSSRRLSLQKIMEHPWIIKN 264
D R+ L + HPWI++N
Sbjct: 338 YDPKDRMRLGDVKMHPWILRN 358
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC
2.7.1.37) (PKA 1) (CDC25 suppressing protein kinase)
(PK-25)
Length = 397
Score = 192 bits (488), Expect = 7e-49
Identities = 98/262 (37%), Positives = 152/262 (57%), Gaps = 7/262 (2%)
Query: 4 EWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQI 63
++S+ DF+I + LG G FGRV++ R + A+KV+ KE + + K E +
Sbjct: 81 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS 140
Query: 64 SLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTY 123
+ HP ++ ++G F D++++F+I++Y GEL+ L K F A Y + AL Y
Sbjct: 141 IVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 200
Query: 124 CHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKDKRKTMCGTLDYLAPEMVENKTHD 183
H +I+RD+KPEN+LLD G +KI DFG++ D T+CGT DY+APE+V K ++
Sbjct: 201 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYN 260
Query: 184 YAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLV 243
++D W+ GIL YE L G PF + T+E+I +L FP P + D K+L+SRL+
Sbjct: 261 KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFP--PFFNEDVKDLLSRLIT 318
Query: 244 KDSSRRL-----SLQKIMEHPW 260
+D S+RL + + HPW
Sbjct: 319 RDLSQRLGNLQNGTEDVKNHPW 340
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC
2.7.1.37) (Polo-like kinase 4) (PLK-4) (Serine/threonine
protein kinase Sak) (Serine/threonine-protein kinase 18)
Length = 970
Score = 190 bits (482), Expect = 4e-48
Identities = 97/264 (36%), Positives = 157/264 (58%), Gaps = 6/264 (2%)
Query: 7 INDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQISLK 66
I DF++G LGKG F VY A + + VA+K+I K+ + K +++ E++I LK
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 67 HPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKR-GHFSEKQAATYILSLTEALTYCH 125
HP++L LY +F DS V+L+LE HNGE+ + L R FSE +A ++ + + Y H
Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
Query: 126 ENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSK---DKRKTMCGTLDYLAPEMVENKTH 182
+ ++HRD+ NLLL +KIADFG + Q K +K T+CGT +Y++PE+ H
Sbjct: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
Query: 183 DYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLL 242
D W+LG + Y L G PPF+ ++ +T ++ D P +S +AK+LI +LL
Sbjct: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMP--TFLSIEAKDLIHQLL 246
Query: 243 VKDSSRRLSLQKIMEHPWIIKNAN 266
++ + RLSL +++HP++ +N++
Sbjct: 247 RRNPADRLSLSSVLDHPFMSRNSS 270
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC
2.7.1.37) (PKA 3)
Length = 398
Score = 190 bits (482), Expect = 4e-48
Identities = 97/262 (37%), Positives = 148/262 (56%), Gaps = 7/262 (2%)
Query: 4 EWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQI 63
++S++DF+I + LG G FGRV++ R + ALK + K + K K E +
Sbjct: 82 KYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLS 141
Query: 64 SLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTY 123
+ HP ++ ++G F DS++VF++++Y GEL+ L K F A Y + AL Y
Sbjct: 142 IVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 201
Query: 124 CHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKDKRKTMCGTLDYLAPEMVENKTHD 183
H +I+RD+KPEN+LLD G +KI DFG++ D T+CGT DY+APE+V K ++
Sbjct: 202 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYN 261
Query: 184 YAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLV 243
+VD W+ G+L YE L G PF + T+E I +L FP P DA++L+ +L+
Sbjct: 262 KSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFP--PFFHPDAQDLLKKLIT 319
Query: 244 KDSSRRL-----SLQKIMEHPW 260
+D S RL + + HPW
Sbjct: 320 RDLSERLGNLQNGSEDVKNHPW 341
>AURB_PIG (Q9N0X0) Serine/threonine-protein kinase 12 (EC 2.7.1.37)
(Aurora-B) (Fragment)
Length = 156
Score = 186 bits (473), Expect = 4e-47
Identities = 95/158 (60%), Positives = 115/158 (72%), Gaps = 3/158 (1%)
Query: 83 VFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTYCHENHVIHRDIKPENLLLD 142
++LILEYA GELYKEL K F E++ AT + L +AL YCH VIHRDIKPENLLL
Sbjct: 1 IYLILEYAPRGELYKELQKCRTFDEQRTATIMEELADALIYCHGKKVIHRDIKPENLLLG 60
Query: 143 HEGRLKIADFGWSVQSKD-KRKTMCGTLDYLAPEMVENKTHDYAVDNWTLGILCYEFLYG 201
+G LKIADFGWSV + +RKTM GTLDYL PEM+E +TH+ VD W +G+LCYE L G
Sbjct: 61 LQGELKIADFGWSVHAPSLRRKTMRGTLDYLPPEMIEGRTHNEKVDLWCIGVLCYELLVG 120
Query: 202 VPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLIS 239
PPFE+ S +T+ RI KVDL FPPS V + A++LIS
Sbjct: 121 NPPFESASHNETYRRIVKVDLKFPPS--VPAGAQDLIS 156
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC
2.7.1.37) (PKA 2)
Length = 380
Score = 186 bits (471), Expect = 7e-47
Identities = 95/262 (36%), Positives = 157/262 (59%), Gaps = 7/262 (2%)
Query: 4 EWSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQI 63
+++++DF+I + LG G FGRV++ R V + A+KV+ K+Q+ K K E +
Sbjct: 64 KYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLK 123
Query: 64 SLKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTY 123
++HP ++ ++G F D+ +F++++Y GEL+ L K F A Y + AL Y
Sbjct: 124 LVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEY 183
Query: 124 CHENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKDKRKTMCGTLDYLAPEMVENKTHD 183
H +++I+RD+KPEN+LLD G +KI DFG++ + + T+CGT DY+APE++ K ++
Sbjct: 184 LHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTKPYN 243
Query: 184 YAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLV 243
+VD W+LG+L YE L G PF + T+E+I + + +P P D +L+S+L+
Sbjct: 244 KSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYP--PYFHPDVVDLLSKLIT 301
Query: 244 KDSSRRL-SLQK----IMEHPW 260
D +RR+ +LQ I HPW
Sbjct: 302 ADLTRRIGNLQSGSRDIKAHPW 323
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC
2.7.1.37) (Polo-like kinase 4) (PLK-4) (Serine/threonine
protein kinase Sak) (Serine/threonine-protein kinase 18)
Length = 925
Score = 185 bits (470), Expect = 9e-47
Identities = 94/262 (35%), Positives = 155/262 (58%), Gaps = 6/262 (2%)
Query: 7 INDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQISLK 66
I DF++G LGKG F VY A + + VA+K+I K+ + K +++ E++I LK
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 67 HPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKR-GHFSEKQAATYILSLTEALTYCH 125
HP+VL LY +F D+ V+L+LE HNGE+ + L R FSE++A ++ + + Y H
Sbjct: 69 HPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLH 128
Query: 126 ENHVIHRDIKPENLLLDHEGRLKIADFGWSVQ---SKDKRKTMCGTLDYLAPEMVENKTH 182
+ ++HRD+ N+LL +KIADFG + Q +K T+CGT +Y++PE+ H
Sbjct: 129 SHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAH 188
Query: 183 DYAVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLL 242
D W+LG + Y L G PPF+ ++ +T ++ D P +S +A++LI +LL
Sbjct: 189 GLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMP--AFLSREAQDLIHQLL 246
Query: 243 VKDSSRRLSLQKIMEHPWIIKN 264
++ + RLSL +++HP++ +N
Sbjct: 247 RRNPADRLSLSSVLDHPFMSRN 268
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit
(EC 2.7.1.37)
Length = 648
Score = 184 bits (467), Expect = 2e-46
Identities = 96/259 (37%), Positives = 150/259 (57%), Gaps = 7/259 (2%)
Query: 7 INDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQISLK 66
+ +F+ + LG G FG+VY+ + K A+K + K + + K L E I S+
Sbjct: 333 LKEFKQIRVLGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIH 392
Query: 67 HPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTYCHE 126
HP +++LY F D ++++L+ EY GE++ L K FS A Y + AL + H+
Sbjct: 393 HPFIVNLYQAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAAEIVLALEFLHK 452
Query: 127 NHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKDKRKTMCGTLDYLAPEMVENKTHDYAV 186
++++RD+KPENLL+D++G +KI DFG++ + +D+ T+CGT +YLAPE++++K H AV
Sbjct: 453 QNIVYRDLKPENLLIDNQGHIKITDFGFAKRVEDRTFTLCGTPEYLAPEIIQSKGHGKAV 512
Query: 187 DNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLVKDS 246
D W LGIL +E L G PPF + + +I ++FP DAK+LI RLL D
Sbjct: 513 DWWALGILIFEMLAGYPPFYDDDTFAIYNKILAGRITFPLG--FDVDAKDLIKRLLTADR 570
Query: 247 SRRLSLQK-----IMEHPW 260
+RRL K + H W
Sbjct: 571 TRRLGALKDGALDVKNHRW 589
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC
2.7.1.37) (Protein kinase PKX1)
Length = 358
Score = 182 bits (461), Expect = 1e-45
Identities = 92/261 (35%), Positives = 148/261 (56%), Gaps = 7/261 (2%)
Query: 5 WSINDFEIGKPLGKGKFGRVYVAREVKSKFVVALKVIFKEQLEKYKFHHQLRREMEIQIS 64
+S+ DF+ +G G FGRV++ +E +K ALKV+ + + K + E +
Sbjct: 44 YSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKE 103
Query: 65 LKHPNVLHLYGWFHDSERVFLILEYAHNGELYKELSKRGHFSEKQAATYILSLTEALTYC 124
+ HP ++ L+ +HD +++++EY GEL+ L RG FS Y + A+ Y
Sbjct: 104 VSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYL 163
Query: 125 HENHVIHRDIKPENLLLDHEGRLKIADFGWSVQSKDKRKTMCGTLDYLAPEMVENKTHDY 184
H +++RD+KPEN+LLD +G +K+ DFG++ + D+ T+CGT +YLAPE++++K H
Sbjct: 164 HSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGR 223
Query: 185 AVDNWTLGILCYEFLYGVPPFEAESQADTFERIKKVDLSFPPSPLVSSDAKNLISRLLVK 244
AVD W LGIL +E L G PPF ++ +++I + FP + K+LI +LLV
Sbjct: 224 AVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRH--LDFHVKDLIKKLLVV 281
Query: 245 DSSRRLSLQK-----IMEHPW 260
D +RRL K + H W
Sbjct: 282 DRTRRLGNMKNGANDVKHHRW 302
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,052,599
Number of Sequences: 164201
Number of extensions: 1306336
Number of successful extensions: 8096
Number of sequences better than 10.0: 1694
Number of HSP's better than 10.0 without gapping: 1572
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 3161
Number of HSP's gapped (non-prelim): 1991
length of query: 271
length of database: 59,974,054
effective HSP length: 108
effective length of query: 163
effective length of database: 42,240,346
effective search space: 6885176398
effective search space used: 6885176398
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Medicago: description of AC149307.9