BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC149127.2 + phase: 0
(458 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MY7A_MOUSE (P97479) Myosin VIIa 47 1e-04
MY7A_HUMAN (Q13402) Myosin VIIa 47 1e-04
ASPM_SHEEP (P62297) Abnormal spindle-like microcephaly-associate... 43 0.002
MLL3_HUMAN (Q8NEZ4) Myeloid/lymphoid or mixed-lineage leukemia p... 42 0.003
MY9B_HUMAN (Q13459) Myosin IXb (Unconventional myosin-9b) 42 0.004
ASPM_BOVIN (P62285) Abnormal spindle-like microcephaly-associate... 42 0.004
MY5A_CHICK (Q02440) Myosin Va (Myosin 5A) (Dilute myosin heavy c... 40 0.012
ASPM_MOUSE (Q8CJ27) Abnormal spindle-like microcephaly-associate... 40 0.016
ASPM_COLGU (P62287) Abnormal spindle-like microcephaly-associate... 40 0.016
MY2A_SACCA (Q875X3) Myosin-2A (Class V unconventional myosin MYO... 39 0.028
ASPM_MACMU (P62292) Abnormal spindle-like microcephaly-associate... 39 0.028
ASPM_MACFA (P62291) Abnormal spindle-like microcephaly-associate... 39 0.028
ASPM_PANTR (P62293) Abnormal spindle-like microcephaly-associate... 39 0.036
ASPM_HUMAN (Q8IZT6) Abnormal spindle-like microcephaly-associate... 39 0.036
ASPM_SAGLB (P62295) Abnormal spindle-like microcephaly-associate... 38 0.047
ASPM_PONPY (P62294) Abnormal spindle-like microcephaly-associate... 38 0.047
ASPM_FELCA (P62288) Abnormal spindle-like microcephaly-associate... 38 0.047
ASPM_CANFA (P62286) Abnormal spindle-like microcephaly-associate... 38 0.047
ASPM_AOTVO (P62283) Abnormal spindle-like microcephaly-associate... 38 0.062
MY5C_HUMAN (Q9NQX4) Myosin Vc (Myosin 5C) 37 0.11
>MY7A_MOUSE (P97479) Myosin VIIa
Length = 2215
Score = 46.6 bits (109), Expect = 1e-04
Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 39/212 (18%)
Query: 98 AATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMT--------MRCMQALV 148
AAT IQ H+RG+ R+ ++ G +RLQAL R + KQ ++ RC LV
Sbjct: 770 AATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIEFQARCRAYLV 829
Query: 149 R------------VQARVRARRVQLSHECLEKAMEEDEEEEFVR--QHETITKPMSPMRR 194
R VQA R + H L + E E +R + E + K MS +
Sbjct: 830 RKAFRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEKLRKEMSAKKA 889
Query: 195 SSVSSNNNNGWDNKCQSVKKAKENDLRKHEAAMKRERALAYAFNYQQQQQKQHLHRNSNG 254
+ + + Q ++ E +L++ E A +++ L +Q +K ++
Sbjct: 890 KEEAERKHQ--ERLAQLAREDAERELKEKEEARRKKELL-------EQMEKARHEPINHS 940
Query: 255 DDVD-----MGTYH--PNDDEKVQWGWNWLER 279
D VD +GT P + + G+ LER
Sbjct: 941 DMVDKMFGFLGTSGSLPGQEGQAPSGFEDLER 972
>MY7A_HUMAN (Q13402) Myosin VIIa
Length = 2215
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/216 (25%), Positives = 93/216 (42%), Gaps = 39/216 (18%)
Query: 94 KEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQ--------AQMTMRCM 144
K + AAT IQ H+RG+ R+ ++ G +RLQAL R + +Q Q RC
Sbjct: 766 KLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQARCR 825
Query: 145 QALVR------------VQARVRARRVQLSHECL--EKAMEEDEEEEFVRQHETITKPMS 190
LVR VQA R + H+ L E + E+ + + E + K MS
Sbjct: 826 AYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMS 885
Query: 191 PMRRSSVSSNNNNGWDNKCQSVKKAKENDLRKHEAAMKRERALAYAFNYQQQQQKQHLHR 250
+ + + + Q ++ E +L++ EAA +++ L +Q ++ +H
Sbjct: 886 AKKAKEEAERKHQ--ERLAQLAREDAERELKEKEAARRKKELL------EQMERARHEPV 937
Query: 251 NSNGDDVD-----MGTYH--PNDDEKVQWGWNWLER 279
N + D VD +GT P + + G+ LER
Sbjct: 938 N-HSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLER 972
>ASPM_SHEEP (P62297) Abnormal spindle-like microcephaly-associated
protein homolog (Fragment)
Length = 3374
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/113 (31%), Positives = 52/113 (45%), Gaps = 9/113 (7%)
Query: 91 RHNKEERAATFIQSHYRGYLARRALRA-----LKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
R+ + AA IQ YR Y RA RA LK + LQA +RG VR Q R
Sbjct: 2054 RYQQMRTAAIVIQVRYRAYRQGRAQRAKYLTTLKAVALLQAALRGARVR---QNLRRMRT 2110
Query: 146 ALVRVQARVRARRVQLSHECLEKAMEEDEEE-EFVRQHETITKPMSPMRRSSV 197
A +QA R RR Q L+K + +++ R+ + + +RRS++
Sbjct: 2111 AATLIQAHYRGRRQQAYFNKLKKVTKTVQQKYRAGRERHAQLRRYNQLRRSAI 2163
Score = 38.1 bits (87), Expect = 0.047
Identities = 36/147 (24%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 97 RAATFIQSHYRGYLA-----RRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQ 151
+AA IQ +YR + A + L+ + + LQA RG+ VR+Q Q A +++Q
Sbjct: 1695 QAAVVIQRYYRAHRAGAQQRKHFLQVRRAVTCLQAAYRGYKVRRQLQQQ---SAAALKIQ 1751
Query: 152 ARVRARRVQLSHE-CLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVS-SNNNNGWDNKC 209
A R R + ++ L+ A++ + + R +++S + GW
Sbjct: 1752 AAFRGYRQRTKYQSMLQSALKIQRWYRTRKMVSALRSHFFKTRTAAISLQSAYRGW---- 1807
Query: 210 QSVKKAKENDLRKHEAAMKRERALAYA 236
K ++ ++HEAA+K + A A
Sbjct: 1808 ----KVRKQMRKEHEAAVKIQSAFRTA 1830
Score = 37.4 bits (85), Expect = 0.081
Identities = 26/66 (39%), Positives = 36/66 (54%), Gaps = 3/66 (4%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRG 130
+AV+ Q+A R R+ + A IQS+YR Y +RR LR K V+LQ++VR
Sbjct: 1569 SAVIVLQSACR--RMQARKKFLHILTAVVKIQSYYRAYASRRKFLRLKKATVKLQSIVRM 1626
Query: 131 HNVRKQ 136
RKQ
Sbjct: 1627 KQARKQ 1632
Score = 37.0 bits (84), Expect = 0.11
Identities = 32/112 (28%), Positives = 47/112 (41%), Gaps = 14/112 (12%)
Query: 56 RNHAIAVAEATAAAASAAVVAAQAAARVVRLAGYGRHNKEER------AATFIQSHYRGY 109
R A+ + A A+ + Q ++ A Y RH + +R AA IQ HYR Y
Sbjct: 1867 RRAAVTLQSAWRGRAARRRIQKQQRCAIIIQACYRRHVQWKRWEIMKKAARLIQMHYRAY 1926
Query: 110 LARRA-----LRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRA 156
R L+ + LQ+ RG RK+ + QA +Q+R RA
Sbjct: 1927 RTGRKQHHLFLKTKGAAIILQSAFRGVRARKKVK---EMHQAATTIQSRYRA 1975
Score = 34.7 bits (78), Expect = 0.53
Identities = 44/180 (24%), Positives = 72/180 (39%), Gaps = 19/180 (10%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLA-----RRALRALKGLVRLQA 126
A+ Q+ R VR+ R ++AA F+Q YR + +R L K ++ +QA
Sbjct: 2328 ASATLIQSRFRSVRVRK--RFLSLKKAAVFVQRKYRATICAKHHLQRFLELKKAIIIIQA 2385
Query: 127 LVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAMEEDEEEEFVRQHETIT 186
R V+KQ Q R A +QA R R +L+ + + A ++QH
Sbjct: 2386 FYRRRMVKKQLQEMHR---AAALIQASFRMHRARLAFQTWKLA------XVLIQQHYRAY 2436
Query: 187 KPMSPMRRSSVSSNNNNGWDNKCQSVKKAKENDLRKHEAAM---KRERALAYAFNYQQQQ 243
+ R + ++ KA++ KH AA+ R F+YQ+ Q
Sbjct: 2437 RAAKLQRALYIRWRHSAVVIQAAYKGLKARQLLREKHRAAVIIQSTYRMYRQHFSYQKLQ 2496
Score = 33.5 bits (75), Expect = 1.2
Identities = 33/120 (27%), Positives = 52/120 (42%), Gaps = 12/120 (10%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRAL-----KGLVRLQ 125
+AA++ A RLA + A IQ HYR Y A + RAL V +Q
Sbjct: 2402 AAALIQASFRMHRARLA----FQTWKLAXVLIQQHYRAYRAAKLQRALYIRWRHSAVVIQ 2457
Query: 126 ALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAMEEDEEEEFVRQHETI 185
A +G R Q+ +A V +Q+ R R S++ L+ A + +E V + + +
Sbjct: 2458 AAYKGLKAR---QLLREKHRAAVIIQSTYRMYRQHFSYQKLQWATKVIQERYRVSKRKAL 2514
Score = 32.3 bits (72), Expect = 2.6
Identities = 22/78 (28%), Positives = 37/78 (47%)
Query: 81 ARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALKGLVRLQALVRGHNVRKQAQMT 140
ARV + K + + IQ+ +R + AR+ LR +K R+QA R RK+
Sbjct: 2836 ARVKGFIQKRKFRKLKDSTIKIQAVWRRHKARKYLREVKAACRIQAWYRCRKARKEYLAV 2895
Query: 141 MRCMQALVRVQARVRARR 158
+R ++ + R + RR
Sbjct: 2896 LRAVRIIQRCFCTQQQRR 2913
Score = 32.0 bits (71), Expect = 3.4
Identities = 28/109 (25%), Positives = 48/109 (43%), Gaps = 11/109 (10%)
Query: 67 AAAASAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARR----ALRALKGLV 122
A ++AAV+ + V+R R + A ++Q YR + R L+ K +
Sbjct: 2180 AMHSAAAVIQRRFRTLVMRR----RFLSLRKTAVWVQRKYRAKVCARHHLQQLQLQKAAI 2235
Query: 123 RLQALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAME 171
++Q+ RG VRK+ Q R L QA R R + ++ +A +
Sbjct: 2236 KIQSWYRGWMVRKKTQEMRRAATVL---QAAFRRHRARARYQAWRRASQ 2281
Score = 32.0 bits (71), Expect = 3.4
Identities = 23/83 (27%), Positives = 42/83 (49%), Gaps = 9/83 (10%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQ--------AQMTMRC 143
++ RAA+ IQ R +L R+ L K + ++QAL RG++ RK+ + ++C
Sbjct: 3097 SQHSRAASVIQRAVRHFLLRKKQENLNKRIAKIQALWRGYSWRKKNDTSKTKAIRQRLQC 3156
Query: 144 MQALVRVQARVRARRVQLSHECL 166
+ +R + ++ R V H L
Sbjct: 3157 VNREIREENKLYHRTVFALHHLL 3179
Score = 31.6 bits (70), Expect = 4.4
Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 4/61 (6%)
Query: 97 RAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVR 155
+AA IQS +RG+ ARR ++ + R+Q+ R H R Q R A+V +Q R
Sbjct: 2585 QAAICIQSCFRGFKARRGIQGMHLAATRIQSCYRRHRARADYQAKKR---AVVVIQNHYR 2641
Query: 156 A 156
+
Sbjct: 2642 S 2642
Score = 30.4 bits (67), Expect = 9.9
Identities = 28/91 (30%), Positives = 46/91 (49%), Gaps = 10/91 (10%)
Query: 85 RLAGYGRHNKEERAATFIQSHYRGYLARRALRALKGLV-----RLQALV---RGHNVRKQ 136
R A R+N+ R+A IQ+ +RG AR+ L+A+ R + LV R ++RK
Sbjct: 2148 RHAQLRRYNQLRRSAICIQAAFRGMRARKRLKAMHSAAAVIQRRFRTLVMRRRFLSLRKT 2207
Query: 137 AQMTMRCMQALVRVQARVRARRVQLSHECLE 167
A R +A +V AR +++QL ++
Sbjct: 2208 AVWVQRKYRA--KVCARHHLQQLQLQKAAIK 2236
Score = 30.4 bits (67), Expect = 9.9
Identities = 27/99 (27%), Positives = 42/99 (42%), Gaps = 4/99 (4%)
Query: 73 AVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALKGLVRL--QALVRG 130
AV QAA R R+ R + AAT IQ+HYRG + LK + + Q G
Sbjct: 2088 AVALLQAALRGARVRQNLRRMRT--AATLIQAHYRGRRQQAYFNKLKKVTKTVQQKYRAG 2145
Query: 131 HNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKA 169
Q + + ++ + +QA R R + + + A
Sbjct: 2146 RERHAQLRRYNQLRRSAICIQAAFRGMRARKRLKAMHSA 2184
>MLL3_HUMAN (Q8NEZ4) Myeloid/lymphoid or mixed-lineage leukemia
protein 3 homolog (Histone-lysine N-methyltransferase, H3
lysine-4 specific MLL3) (EC 2.1.1.43) (Homologous to ALR
protein)
Length = 4911
Score = 42.0 bits (97), Expect = 0.003
Identities = 60/226 (26%), Positives = 94/226 (41%), Gaps = 43/226 (19%)
Query: 151 QARVRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQ 210
+A +R +VQ+S++ +++ ++D + R + K P+++ S + W + Q
Sbjct: 1701 RAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFK--DPLKQRE--SEHEQEWKFRQQ 1756
Query: 211 SVKKAKENDLRKHEAAMKRERALAYAFNYQQQQQK-----QHLHRNSNGDDVDMGTYHPN 265
+K+K+ K EA K E+ N QQQQQ+ QHL S D G P
Sbjct: 1757 MRQKSKQQ--AKIEATQKLEQVK----NEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSP- 1809
Query: 266 DDEKVQWGWNWLERWMSSQPYNVRHMVPRESSYMTL-----PST-TSTTTDNMSEKTVEM 319
++ QP N +M P +S + L PST TST++D++ K
Sbjct: 1810 ---------------LTPQPGN-GNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAP 1853
Query: 320 DIMATPSRGNFNMGPMGLMAQEFHDSSPTF---NRQHQRPPSPGRP 362
PSR + AQ SP + RPPSP P
Sbjct: 1854 PPPPAPSR--IPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDP 1897
>MY9B_HUMAN (Q13459) Myosin IXb (Unconventional myosin-9b)
Length = 2158
Score = 41.6 bits (96), Expect = 0.004
Identities = 30/84 (35%), Positives = 44/84 (51%), Gaps = 5/84 (5%)
Query: 96 ERAATFIQSHYRGYLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVR 155
+RAA IQ+ +R Y RRAL + V LQA RG+ RK + Q+++R+Q+ R
Sbjct: 980 KRAAVTIQACWRSYRVRRALERTQAAVYLQAAWRGYWQRK---LYRHQKQSIIRLQSLCR 1036
Query: 156 A--RRVQLSHECLEKAMEEDEEEE 177
+R S EK E++E E
Sbjct: 1037 GHLQRKSFSQMISEKQKAEEKERE 1060
>ASPM_BOVIN (P62285) Abnormal spindle-like microcephaly-associated
protein homolog (Fragment)
Length = 3371
Score = 41.6 bits (96), Expect = 0.004
Identities = 40/149 (26%), Positives = 72/149 (47%), Gaps = 24/149 (16%)
Query: 98 AATFIQSHYRGYLA-----RRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA IQ +YR + A + L+ + + LQA RG+ VR+Q Q A +++QA
Sbjct: 1693 AAVVIQRYYRAHRAGAQQRKHFLQVRRAVTYLQATYRGYKVRRQLQQQ---SAAALKIQA 1749
Query: 153 RVRARRVQLSHE-CLEKAMEEDEEEEFVRQHETITKPMS---PMRRSSVS-SNNNNGWDN 207
R R + ++ L+ A+ + + + R H+T++ S R +++S + GW
Sbjct: 1750 AFRGYRQRTKYQSVLQSAL---KIQRWYRTHKTVSAIRSHFFKTRTAAISLQSAYRGW-- 1804
Query: 208 KCQSVKKAKENDLRKHEAAMKRERALAYA 236
K ++ ++HEAA+K + A A
Sbjct: 1805 ------KVRKQMRKEHEAAVKIQSAFRTA 1827
Score = 40.0 bits (92), Expect = 0.012
Identities = 33/112 (29%), Positives = 49/112 (43%), Gaps = 14/112 (12%)
Query: 56 RNHAIAVAEATAAAASAAVVAAQAAARVVRLAGYGRHNKEER------AATFIQSHYRGY 109
R A+ + A A+ + Q ++ A Y RH +++R AA IQ HYR Y
Sbjct: 1864 RRAAVMLQSAWRGRAARRRIQKQQRCAIIIQAYYRRHVQQKRWEIMKKAAHLIQMHYRAY 1923
Query: 110 LARRA-----LRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRA 156
R L+ + LQ+ RG VRK+ + QA +Q+R RA
Sbjct: 1924 RTGRKQHHLFLKTKXAAIILQSAFRGVRVRKKVK---EMHQAAATIQSRYRA 1972
Score = 35.8 bits (81), Expect = 0.24
Identities = 44/173 (25%), Positives = 72/173 (41%), Gaps = 10/173 (5%)
Query: 68 AAASAAVVAAQAAARVVRLAGYGRHN--KEERAATFIQSHYRGYLARRALRALKGLVRL- 124
A+ AA V Q R +LAG R ++AA IQ+ YRG ARR +R + L
Sbjct: 1980 ASYRAAAVIIQRWYRAAKLAGRQREEYLAVKKAALKIQAVYRGVRARRHIRRMHMAATLI 2039
Query: 125 -QALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKA---MEEDEEEEFVR 180
A + R+ QM + VR +A + R + + + KA ++ VR
Sbjct: 2040 KAAFKMQQSRRRYQQMRTAAIIIQVRYRAYCQGRAQRAKYLMILKAVALLQAALRGARVR 2099
Query: 181 QHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKKAKENDLRKHEAAMKRERAL 233
Q + + + ++ + NK + V K + +K+ AA +R L
Sbjct: 2100 QSLRRMRTAATLIQAHYRGRRQQAYFNKLKKVTKTVQ---QKYRAARERHAQL 2149
Score = 35.4 bits (80), Expect = 0.31
Identities = 23/67 (34%), Positives = 38/67 (56%), Gaps = 3/67 (4%)
Query: 96 ERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AA IQS YRG++ R+ ++ + + LQA R H R + Q RC +++ + R
Sbjct: 2228 QKAAIKIQSWYRGWMVRKKIQEMRRAATVLQAAFRRHRTRARYQ-AWRCASQVIQQRFRA 2286
Query: 155 -RARRVQ 160
RA R+Q
Sbjct: 2287 GRAARLQ 2293
Score = 34.7 bits (78), Expect = 0.53
Identities = 25/66 (37%), Positives = 36/66 (53%), Gaps = 3/66 (4%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRG 130
+AV+ Q+A R R+ + + IQS+YR Y +RR LR K V+LQ++VR
Sbjct: 1566 SAVIVLQSACR--RMQARKKFLHILTSIVKIQSYYRAYASRRKFLRLKKATVKLQSIVRM 1623
Query: 131 HNVRKQ 136
RKQ
Sbjct: 1624 KLARKQ 1629
Score = 32.3 bits (72), Expect = 2.6
Identities = 18/59 (30%), Positives = 32/59 (53%), Gaps = 3/59 (5%)
Query: 105 HYRGYLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQLSH 163
H R +R ++LQA +RG+ VRKQ ++ + A V +Q+ R R+++L +
Sbjct: 1632 HLRAIAQQREEHRRASCIKLQAFLRGYLVRKQVRLQRK---AAVSLQSYFRMRKMRLDY 1687
Score = 32.3 bits (72), Expect = 2.6
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 5/81 (6%)
Query: 92 HNKEERAATFIQSHYRGY----LARRALRALKGLVR-LQALVRGHNVRKQAQMTMRCMQA 146
+ ++RA IQ+HYR Y + R+ A++ R +QA RG VR++ + A
Sbjct: 2623 YQAKKRAVVVIQNHYRSYIRVKMERKEFLAIQKSARTIQAAFRGMKVRQKLKTMPDKKMA 2682
Query: 147 LVRVQARVRARRVQLSHECLE 167
Q R + HE E
Sbjct: 2683 APATQPAFYCHRTESQHEAGE 2703
Score = 32.0 bits (71), Expect = 3.4
Identities = 20/76 (26%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 94 KEERAATFIQSHYRGYLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQAR 153
++ AA +Q+ +RG AR R +K LQ+ R +R+ + + ++R+QA
Sbjct: 1468 QKRAAAIRLQAAFRGRRARNLCRQIKAACVLQSYWR---MRQDRLRFLNLKKNIIRLQAH 1524
Query: 154 VRARRVQLSHECLEKA 169
+R R+ +++ ++KA
Sbjct: 1525 IRRRQQLHTYQKMKKA 1540
Score = 31.2 bits (69), Expect = 5.8
Identities = 22/82 (26%), Positives = 40/82 (47%), Gaps = 9/82 (10%)
Query: 94 KEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT--------MRCM 144
+ RAA+ IQ R +L R+ K + ++QAL RG++ RK+ T ++C+
Sbjct: 3095 QHSRAASVIQRAVRRFLLRKKQENFNKRIAKIQALWRGYSWRKKNDSTKTKAIRQRLQCV 3154
Query: 145 QALVRVQARVRARRVQLSHECL 166
+R ++++ R H L
Sbjct: 3155 NREIREESKLYHRTAVALHHLL 3176
Score = 30.4 bits (67), Expect = 9.9
Identities = 20/78 (25%), Positives = 39/78 (49%), Gaps = 2/78 (2%)
Query: 94 KEERAATFIQSHYRGYLARRALR-ALKGLVRLQALVRGHNVRKQAQMTMRCMQALVR-VQ 151
K AA +QS YRG+ R+ +R + V++Q+ R +K+ ++ + + ++
Sbjct: 1789 KTRTAAISLQSAYRGWKVRKQMRKEHEAAVKIQSAFRTARAQKEFRVLKTAASVIQQHLR 1848
Query: 152 ARVRARRVQLSHECLEKA 169
AR RR + + L +A
Sbjct: 1849 ARAAGRRQRTEYTALRRA 1866
>MY5A_CHICK (Q02440) Myosin Va (Myosin 5A) (Dilute myosin heavy
chain, non-muscle) (Myosin heavy chain P190) (Myosin-V)
Length = 1829
Score = 40.0 bits (92), Expect = 0.012
Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 73 AVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGH 131
A + Q R + Y + RAA IQ R Y+ R+ + ++ + LQAL+RG+
Sbjct: 793 AAITIQRYVRGHQARCYATFLRRTRAAIIIQKFQRMYVVRKRYQCMRDATIALQALLRGY 852
Query: 132 NVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAM 170
VR + QM +R ++++ +Q VR ++ + KA+
Sbjct: 853 LVRNKYQMMLREHKSII-IQKHVRGWLARVHYHRTLKAI 890
>ASPM_MOUSE (Q8CJ27) Abnormal spindle-like microcephaly-associated
protein homolog (Calmodulin-binding protein 1) (Spindle
and hydroxyurea checkpoint abnormal protein)
(Calmodulin-binding protein Sha1)
Length = 3122
Score = 39.7 bits (91), Expect = 0.016
Identities = 40/147 (27%), Positives = 65/147 (44%), Gaps = 33/147 (22%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
+RAA +Q+ YRG RR ++ V +Q + RGH+ R + Q TM +Q+ V++Q
Sbjct: 1770 KRAAICLQAAYRGCKVRRQIKQQSTAAVTIQRVFRGHSQRMKYQ-TM--LQSAVKIQRWY 1826
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA++V D +F++ E + S R GW +
Sbjct: 1827 RAQKVAY-----------DMRIQFLKTREAVVCLQSAYR----------GW--------Q 1857
Query: 215 AKENDLRKHEAAMKRERALAYAFNYQQ 241
++ R+HEAA+K + A QQ
Sbjct: 1858 VRQQLRRQHEAAVKIQSTFRMAVAQQQ 1884
Score = 38.5 bits (88), Expect = 0.036
Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+AA++ + + + G + K RAA IQ+H+RGY AR++ L+ ++ +Q VR
Sbjct: 2650 AAAIIIQRKWRATLSVRGARENLKRHRAACVIQAHFRGYQARQSFLQQRSAVLIIQRHVR 2709
Query: 130 GHNVRKQAQMT-MRCMQALVRVQARVR 155
KQ ++ ++ ++ V VQA VR
Sbjct: 2710 AMVAAKQERIKYIKLKKSTVVVQALVR 2736
Score = 37.4 bits (85), Expect = 0.081
Identities = 32/85 (37%), Positives = 39/85 (45%), Gaps = 10/85 (11%)
Query: 91 RHNKEERAATFIQSHYRGYLA-----RRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
R+ K AA IQ YR Y + LR LK + LQA VRG VR+ T+R M
Sbjct: 2103 RYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRR----TVRKMH 2158
Query: 146 -ALVRVQARVRARRVQLSHECLEKA 169
A +Q+ R R Q L KA
Sbjct: 2159 FAATLIQSHFRGHRQQTYFHRLRKA 2183
Score = 33.5 bits (75), Expect = 1.2
Identities = 26/105 (24%), Positives = 51/105 (47%), Gaps = 7/105 (6%)
Query: 63 AEATAAAASAAVVAAQAAARVVRLAGYGRH-----NKEERAATFIQSHYRGYLARRALRA 117
A A A + + AA V + A G+ ++ + A IQS+YR ++ RR
Sbjct: 1901 ARAAGKRQHLAYIQLRHAALVFQAAWKGKMLRRQIARQHQCAALIQSYYRMHIQRRKWSI 1960
Query: 118 LK-GLVRLQALVRGHNV-RKQAQMTMRCMQALVRVQARVRARRVQ 160
+K +++Q R + V ++Q + ++ A+V +Q+ R +V+
Sbjct: 1961 MKTAALQIQLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRGMKVR 2005
Score = 33.1 bits (74), Expect = 1.5
Identities = 27/123 (21%), Positives = 55/123 (43%), Gaps = 17/123 (13%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRG 130
++V+ Q+A R ++ RH + IQS+YR Y+ R+ + K ++LQ++V+
Sbjct: 1602 SSVIVLQSACRGMQARKAFRHALA--SVIKIQSYYRAYICRKTFQNFKNATIKLQSIVKM 1659
Query: 131 HNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMS 190
RKQ ++RA + + + + + +E+++ E+ K S
Sbjct: 1660 KQSRKQ--------------YLQIRAAALFIQRWYRSQKLASQKRKEYIQVRESCIKLQS 1705
Query: 191 PMR 193
R
Sbjct: 1706 HFR 1708
Score = 32.0 bits (71), Expect = 3.4
Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 14/133 (10%)
Query: 94 KEERAATFIQSHYRGYLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQAR 153
++ AA Q H+R + ARR + A +G QA R + +K + ++A R+QA
Sbjct: 2560 QQHGAAMITQKHFRAFKARRLMEAERG---FQAGCRKYKAKKY----LSKVEAACRIQAW 2612
Query: 154 VRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVK 213
R R + L KA+ E + + MR +++ W SV+
Sbjct: 2613 YRRWRAHKKYLTLLKAVNIIEG---YLSAQLARRRFLKMRAAAIIIQRK--W-RATLSVR 2666
Query: 214 KAKENDLRKHEAA 226
A+EN L++H AA
Sbjct: 2667 GAREN-LKRHRAA 2678
Score = 32.0 bits (71), Expect = 3.4
Identities = 26/95 (27%), Positives = 43/95 (44%), Gaps = 15/95 (15%)
Query: 102 IQSHYRGYLARRALR-ALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQ 160
+QSH+RG L R+ LR K + LQ+ R +R Q ++ +A + +Q+ A R Q
Sbjct: 1703 LQSHFRGCLVRKQLRLQCKAAISLQSYFR---MRTARQRYLKMCKAALVIQSFYCAYRAQ 1759
Query: 161 LSHE-----------CLEKAMEEDEEEEFVRQHET 184
+S CL+ A + ++Q T
Sbjct: 1760 ISQRKNFLQVKRAAICLQAAYRGCKVRRQIKQQST 1794
>ASPM_COLGU (P62287) Abnormal spindle-like microcephaly-associated
protein homolog
Length = 3477
Score = 39.7 bits (91), Expect = 0.016
Identities = 34/142 (23%), Positives = 62/142 (42%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ V++Q+ RG+N R + Q +Q+++++Q
Sbjct: 1802 KKAATCLQAAYRGYKIRQLIKQQSIAAVKIQSAFRGYNKRVKYQSV---LQSIIKIQRWY 1858
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1859 RAYKTL-----------HDTRTHFLKTKAAVVSLQSAYR----------GW--------K 1889
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AA+K + A A
Sbjct: 1890 VRKQIRREHQAALKIQSAFRMA 1911
Score = 35.8 bits (81), Expect = 0.24
Identities = 21/71 (29%), Positives = 41/71 (57%), Gaps = 8/71 (11%)
Query: 91 RHNKEERAATFIQSHYRGYL-ARRAL----RALKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
++ K ++AA IQ+H+R Y+ AR+ L + ++ LQ+ RG RK M + +
Sbjct: 1601 KYKKMKKAAVIIQTHFRAYIFARKVLASYQKTRSAVIVLQSAYRGMQARK---MYIHILT 1657
Query: 146 ALVRVQARVRA 156
+++++Q+ RA
Sbjct: 1658 SVIKIQSYYRA 1668
Score = 35.4 bits (80), Expect = 0.31
Identities = 34/148 (22%), Positives = 73/148 (48%), Gaps = 11/148 (7%)
Query: 102 IQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQ 160
IQS+YR Y++++ +LK ++LQ++V+ RKQ + +R ++ R + Q
Sbjct: 1662 IQSYYRAYVSKKEFLSLKNATIKLQSIVKMKQTRKQ-YLHLRAAALFIQQCYRSKKIATQ 1720
Query: 161 LSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKKAKENDL 220
E ++ + + FVR + + K M R++ +S + ++KA++ L
Sbjct: 1721 KREEYMQMRESCIKLQAFVRGY-LVRKQMRLQRKAVISLQS-------YFRMRKARQYYL 1772
Query: 221 RKHEAAMKRERALAYAFNYQQQQQKQHL 248
+ ++A + + +A+ Q Q+K+ L
Sbjct: 1773 KMYKAIIVIQN-YYHAYKAQVNQRKKFL 1799
Score = 34.7 bits (78), Expect = 0.53
Identities = 25/79 (31%), Positives = 40/79 (49%), Gaps = 11/79 (13%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNVRKQAQM-------TMRCMQ 145
K RAA IQ+HYRGY R+ LR + +Q +R K+ ++ + +Q
Sbjct: 3028 KRHRAACLIQAHYRGYKERQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQ 3087
Query: 146 ALVR---VQARVRARRVQL 161
ALVR V+ R+ +R ++
Sbjct: 3088 ALVRGWLVRKRILEQRTKI 3106
Score = 32.7 bits (73), Expect = 2.0
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 98 AATFIQSHYRG-----YLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA FIQ YR ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 1704 AALFIQQCYRSKKIATQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRK---AVISLQS 1760
Query: 153 RVRARRVQLSHECLEKAM 170
R R+ + + + KA+
Sbjct: 1761 YFRMRKARQYYLKMYKAI 1778
Score = 30.4 bits (67), Expect = 9.9
Identities = 16/49 (32%), Positives = 29/49 (58%), Gaps = 1/49 (2%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
++ RAA+ IQ R ++ R+ G++++QAL RG++ RK+ T
Sbjct: 3179 SQRNRAASVIQKAVRHFVLRKKQEKFTSGIIKIQALWRGYSWRKKNDCT 3227
>MY2A_SACCA (Q875X3) Myosin-2A (Class V unconventional myosin MYO2A)
(Type V myosin heavy chain MYO2A) (Myosin V MYO2A)
Length = 1567
Score = 38.9 bits (89), Expect = 0.028
Identities = 26/88 (29%), Positives = 47/88 (52%), Gaps = 4/88 (4%)
Query: 70 ASAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALR-ALKGLVRLQALV 128
AS +++ A + V+R + E+ AAT IQ+ YRGY R + + +V+LQ+ +
Sbjct: 814 ASLSLLGAYSKGTVIRQRV--EYELEQHAATLIQTMYRGYSKRSYISGVISSIVKLQSRI 871
Query: 129 RGHNVRKQAQMTMRCMQALVRVQARVRA 156
R +++ Q A + +Q+R+RA
Sbjct: 872 REELEQREMQSKYE-SNAAISIQSRIRA 898
>ASPM_MACMU (P62292) Abnormal spindle-like microcephaly-associated
protein homolog
Length = 3479
Score = 38.9 bits (89), Expect = 0.028
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ +++Q+ RG+N R + Q +Q+++++Q
Sbjct: 1802 KKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSV---LQSIIKIQRWY 1858
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1859 RAYKTL-----------HDTRTHFLKTKAAVVSLQSAYR----------GW--------K 1889
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AA+K + A A
Sbjct: 1890 VRKQIRREHQAALKIQSAFRMA 1911
Score = 34.7 bits (78), Expect = 0.53
Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 11/148 (7%)
Query: 102 IQSHYRGYLARRALRALKG-LVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQ 160
IQS+YR Y++++ +LK ++LQ++V+ RKQ + +R ++ R + Q
Sbjct: 1662 IQSYYRAYVSKKEFLSLKNTTIKLQSIVKMKQTRKQ-YLHLRAAALFIQQCYRSKKITTQ 1720
Query: 161 LSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKKAKENDL 220
E ++ + + FVR + + K M R++ +S + ++KA++ L
Sbjct: 1721 KREEYMQMRESCIKLQAFVRGY-LVRKQMRLQRKAVISLQS-------YFRMRKARQYYL 1772
Query: 221 RKHEAAMKRERALAYAFNYQQQQQKQHL 248
+ +A M + +A+ Q Q+K L
Sbjct: 1773 KMCKAIMVIQN-YYHAYKAQVNQRKNFL 1799
Score = 33.9 bits (76), Expect = 0.90
Identities = 22/64 (34%), Positives = 34/64 (52%), Gaps = 2/64 (3%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNVRKQAQMT-MRCMQALVRVQ 151
K RAA IQ+HYRGY R+ LR + +Q +R K+ ++ + ++ V +Q
Sbjct: 3031 KRHRAACLIQAHYRGYKERQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQ 3090
Query: 152 ARVR 155
A VR
Sbjct: 3091 ALVR 3094
Score = 33.5 bits (75), Expect = 1.2
Identities = 18/71 (25%), Positives = 39/71 (54%), Gaps = 8/71 (11%)
Query: 91 RHNKEERAATFIQSHYRGYLARRAL-----RALKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
++ K ++AA IQ+H+R Y+ R + + ++ LQ+ RG RK + + +
Sbjct: 1601 KYKKMKKAAVIIQTHFRAYIFTRKVLASYQKTRSAVIVLQSAYRGMQARK---VYIHILT 1657
Query: 146 ALVRVQARVRA 156
+++++Q+ RA
Sbjct: 1658 SVIKIQSYYRA 1668
Score = 32.0 bits (71), Expect = 3.4
Identities = 21/68 (30%), Positives = 36/68 (52%), Gaps = 8/68 (11%)
Query: 98 AATFIQSHYRG-----YLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA FIQ YR ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 1704 AALFIQQCYRSKKITTQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRK---AVISLQS 1760
Query: 153 RVRARRVQ 160
R R+ +
Sbjct: 1761 YFRMRKAR 1768
Score = 31.2 bits (69), Expect = 5.8
Identities = 25/127 (19%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A ++ A + + K A +QS YRG AR+ + L ++++Q+ R
Sbjct: 1608 AAVIIQTHFRAYIFTRKVLASYQKTRSAVIVLQSAYRGMQARKVYIHILTSVIKIQSYYR 1667
Query: 130 GHNVRKQ---AQMTMRCMQALVRVQ------ARVRARRVQLSHECLEKAMEEDEEEEFVR 180
+ +K+ + T +Q++V+++ +RA + + K + + EE+++
Sbjct: 1668 AYVSKKEFLSLKNTTIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKITTQKREEYMQ 1727
Query: 181 QHETITK 187
E+ K
Sbjct: 1728 MRESCIK 1734
Score = 31.2 bits (69), Expect = 5.8
Identities = 16/49 (32%), Positives = 30/49 (60%), Gaps = 1/49 (2%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
+++ RAA+ IQ R ++ R+ G++++QAL RG++ RK+ T
Sbjct: 3181 SQQNRAASVIQKAVRHFVLRKKQEKFTSGIIKIQALWRGYSWRKKNDCT 3229
Score = 30.8 bits (68), Expect = 7.6
Identities = 32/129 (24%), Positives = 56/129 (42%), Gaps = 17/129 (13%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRG 130
AAVV Q+A R +++ R +AA IQS YR Y ++ + + +Q RG
Sbjct: 2022 AAVVTLQSAYRGMKVRK--RIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRG 2079
Query: 131 HNV-RKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPM 189
+ +Q Q + + +++Q+ R RV+ + + +A T K M
Sbjct: 2080 IKITHRQHQEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRA-------------ATFIKAM 2126
Query: 190 SPMRRSSVS 198
M +S +S
Sbjct: 2127 FKMHQSRIS 2135
>ASPM_MACFA (P62291) Abnormal spindle-like microcephaly-associated
protein homolog
Length = 3476
Score = 38.9 bits (89), Expect = 0.028
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ +++Q+ RG+N R + Q +Q+++++Q
Sbjct: 1802 KKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSV---LQSIIKIQRWY 1858
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1859 RAYKTL-----------HDTRTRFLKTKAAVVSLQSAYR----------GW--------K 1889
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AA+K + A A
Sbjct: 1890 VRKQIRREHQAALKIQSAFRMA 1911
Score = 33.9 bits (76), Expect = 0.90
Identities = 22/64 (34%), Positives = 34/64 (52%), Gaps = 2/64 (3%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNVRKQAQMT-MRCMQALVRVQ 151
K RAA IQ+HYRGY R+ LR + +Q +R K+ ++ + ++ V +Q
Sbjct: 3028 KRHRAACLIQAHYRGYKERQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQ 3087
Query: 152 ARVR 155
A VR
Sbjct: 3088 ALVR 3091
Score = 33.5 bits (75), Expect = 1.2
Identities = 25/98 (25%), Positives = 50/98 (50%), Gaps = 3/98 (3%)
Query: 102 IQSHYRGYLARRALRALKG-LVRLQALVRGHNVRKQAQMTMRCMQALVRVQARVRARRVQ 160
IQS+YR Y++++ +LK ++LQ++V+ RKQ + +R ++ R + Q
Sbjct: 1662 IQSYYRAYVSKKEFLSLKNTTIKLQSIVKMKQTRKQ-YLHLRAAALFIQQCYRSKKITTQ 1720
Query: 161 LSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVS 198
E ++ + + FVR + + K M R++ +S
Sbjct: 1721 KREEYMQMRESCIKLQAFVRGY-LVRKQMRLQRKAVIS 1757
Score = 33.5 bits (75), Expect = 1.2
Identities = 18/71 (25%), Positives = 39/71 (54%), Gaps = 8/71 (11%)
Query: 91 RHNKEERAATFIQSHYRGYLARRAL-----RALKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
++ K ++AA IQ+H+R Y+ R + + ++ LQ+ RG RK + + +
Sbjct: 1601 KYKKMKKAAVIIQTHFRAYIFTRKVLASYQKTRSAVIVLQSAYRGMQARK---VYIHILT 1657
Query: 146 ALVRVQARVRA 156
+++++Q+ RA
Sbjct: 1658 SVIKIQSYYRA 1668
Score = 32.0 bits (71), Expect = 3.4
Identities = 21/68 (30%), Positives = 36/68 (52%), Gaps = 8/68 (11%)
Query: 98 AATFIQSHYRG-----YLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA FIQ YR ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 1704 AALFIQQCYRSKKITTQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRK---AVISLQS 1760
Query: 153 RVRARRVQ 160
R R+ +
Sbjct: 1761 YFRMRKAR 1768
Score = 31.2 bits (69), Expect = 5.8
Identities = 25/127 (19%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A ++ A + + K A +QS YRG AR+ + L ++++Q+ R
Sbjct: 1608 AAVIIQTHFRAYIFTRKVLASYQKTRSAVIVLQSAYRGMQARKVYIHILTSVIKIQSYYR 1667
Query: 130 GHNVRKQ---AQMTMRCMQALVRVQ------ARVRARRVQLSHECLEKAMEEDEEEEFVR 180
+ +K+ + T +Q++V+++ +RA + + K + + EE+++
Sbjct: 1668 AYVSKKEFLSLKNTTIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKITTQKREEYMQ 1727
Query: 181 QHETITK 187
E+ K
Sbjct: 1728 MRESCIK 1734
Score = 31.2 bits (69), Expect = 5.8
Identities = 16/49 (32%), Positives = 30/49 (60%), Gaps = 1/49 (2%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
+++ RAA+ IQ R ++ R+ G++++QAL RG++ RK+ T
Sbjct: 3178 SQQNRAASVIQKAVRHFVLRKKQEKFTSGIIKIQALWRGYSWRKKNDCT 3226
>ASPM_PANTR (P62293) Abnormal spindle-like microcephaly-associated
protein homolog
Length = 3477
Score = 38.5 bits (88), Expect = 0.036
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ +++Q+ RG+N R + Q +Q+++++Q
Sbjct: 1802 KKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSV---LQSIIKIQRWY 1858
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1859 RAYKTL-----------HDTRTHFLKTKAAVISLQSAYR----------GW--------K 1889
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AA+K + A A
Sbjct: 1890 VRKQIRREHQAALKIQSAFRMA 1911
Score = 35.8 bits (81), Expect = 0.24
Identities = 36/155 (23%), Positives = 76/155 (48%), Gaps = 25/155 (16%)
Query: 102 IQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQ-------AQMTMRCMQALVRVQAR 153
IQS+YR Y++++ +LK ++LQ++V+ RKQ A +C ++ ++ A+
Sbjct: 1662 IQSYYRAYVSKKEFLSLKNATIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRS-KKIAAQ 1720
Query: 154 VRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVK 213
R +Q+ C++ + FVR + + K M R++ +S + ++
Sbjct: 1721 KREEYMQMRESCIKL-------QAFVRGY-LVRKQMRLRRKAVISLQS-------YFRMR 1765
Query: 214 KAKENDLRKHEAAMKRERALAYAFNYQQQQQKQHL 248
KA++ L+ ++A + + +A+ Q Q+K L
Sbjct: 1766 KAQQYYLKMYKAIIVIQN-YYHAYKAQVNQRKNFL 1799
Score = 35.4 bits (80), Expect = 0.31
Identities = 32/86 (37%), Positives = 46/86 (53%), Gaps = 7/86 (8%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLAR-RALRALKGLVRLQALVRG 130
AA + QAA R RL + + ++ RAA IQS++R R R L K +++LQA VR
Sbjct: 1539 AAAIQLQAAFR--RLKAHNLY-RQIRAACVIQSYWRMRQDRVRFLNLKKTIIKLQAHVRK 1595
Query: 131 HNVRKQAQMTMRCMQALVRVQARVRA 156
H +Q Q + +A V +Q RA
Sbjct: 1596 H---QQRQKYKKMKKAAVIIQTHFRA 1618
Score = 35.0 bits (79), Expect = 0.40
Identities = 25/79 (31%), Positives = 40/79 (49%), Gaps = 11/79 (13%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNVRKQAQM-------TMRCMQ 145
K RAA IQ+HYRGY R+ LR + +Q +R K+ ++ + +Q
Sbjct: 3028 KRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQ 3087
Query: 146 ALVR---VQARVRARRVQL 161
ALVR V+ R+ +R ++
Sbjct: 3088 ALVRGWLVRKRILEQRAKI 3106
Score = 34.3 bits (77), Expect = 0.69
Identities = 24/78 (30%), Positives = 41/78 (51%), Gaps = 8/78 (10%)
Query: 98 AATFIQSHYRG-----YLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA FIQ YR ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 1704 AALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLRRK---AVISLQS 1760
Query: 153 RVRARRVQLSHECLEKAM 170
R R+ Q + + KA+
Sbjct: 1761 YFRMRKAQQYYLKMYKAI 1778
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/71 (28%), Positives = 41/71 (57%), Gaps = 8/71 (11%)
Query: 91 RHNKEERAATFIQSHYRGYL-ARRALRALK----GLVRLQALVRGHNVRKQAQMTMRCMQ 145
++ K ++AA IQ+H+R Y+ A + L + + ++ LQ+ RG RK M + +
Sbjct: 1601 KYKKMKKAAVIIQTHFRAYIFAMKVLASYQKIRSAVIVLQSAYRGMQARK---MYIHILT 1657
Query: 146 ALVRVQARVRA 156
+++++Q+ RA
Sbjct: 1658 SVIKIQSYYRA 1668
Score = 31.6 bits (70), Expect = 4.4
Identities = 17/49 (34%), Positives = 29/49 (58%), Gaps = 1/49 (2%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
++ RAA+ IQ R +L R+ G++++QAL RG++ RK+ T
Sbjct: 3179 SQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCT 3227
Score = 30.8 bits (68), Expect = 7.6
Identities = 24/130 (18%), Positives = 58/130 (44%), Gaps = 16/130 (12%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A ++ A + + + K A +QS YRG AR+ + L ++++Q+ R
Sbjct: 1608 AAVIIQTHFRAYIFAMKVLASYQKIRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYR 1667
Query: 130 GHNVRKQAQMTMRCMQALVRVQARVRARRVQLSH-----------ECL-EKAMEEDEEEE 177
+ +K+ + A +++Q+ V+ ++ + + +C K + + EE
Sbjct: 1668 AYVSKKE---FLSLKNATIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREE 1724
Query: 178 FVRQHETITK 187
+++ E+ K
Sbjct: 1725 YMQMRESCIK 1734
Score = 30.4 bits (67), Expect = 9.9
Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 73 AVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALKGLVR-LQALVRGH 131
AV QA+ R VR+ R K + AAT IQS+YR Y + LK + + +Q R
Sbjct: 2169 AVKVLQASFRGVRVRRTLR--KMQIAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYRAM 2226
Query: 132 NVRK-QAQMTMRCMQALVRVQARVRARRVQ 160
R Q Q + +++ +QA R ++ +
Sbjct: 2227 KERNIQFQRYNKLRHSVIYIQAIFRGKKAR 2256
>ASPM_HUMAN (Q8IZT6) Abnormal spindle-like microcephaly-associated
protein (Abnormal spindle protein homolog) (Asp homolog)
Length = 3477
Score = 38.5 bits (88), Expect = 0.036
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ +++Q+ RG+N R + Q +Q+++++Q
Sbjct: 1802 KKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSV---LQSIIKIQRWY 1858
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1859 RAYKTL-----------HDTRTHFLKTKAAVISLQSAYR----------GW--------K 1889
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AA+K + A A
Sbjct: 1890 VRKQIRREHQAALKIQSAFRMA 1911
Score = 33.9 bits (76), Expect = 0.90
Identities = 22/64 (34%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNVRKQAQMT-MRCMQALVRVQ 151
K RAA IQ+HYRGY R+ LR + +Q +R K ++ + ++ V +Q
Sbjct: 3028 KRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKHERIKYIEFKKSTVILQ 3087
Query: 152 ARVR 155
A VR
Sbjct: 3088 ALVR 3091
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/71 (28%), Positives = 40/71 (56%), Gaps = 8/71 (11%)
Query: 91 RHNKEERAATFIQSHYRGYL-ARRAL----RALKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
++ K ++AA IQ+H+R Y+ A + L + ++ LQ+ RG RK M + +
Sbjct: 1601 KYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARK---MYIHILT 1657
Query: 146 ALVRVQARVRA 156
+++++Q+ RA
Sbjct: 1658 SVIKIQSYYRA 1668
Score = 32.7 bits (73), Expect = 2.0
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 98 AATFIQSHYRG-----YLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA FIQ YR ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 1704 AALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRK---AVISLQS 1760
Query: 153 RVRARRVQLSHECLEKAM 170
R R+ + + + KA+
Sbjct: 1761 YFRMRKARQYYLKMYKAI 1778
Score = 32.3 bits (72), Expect = 2.6
Identities = 24/130 (18%), Positives = 58/130 (44%), Gaps = 16/130 (12%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A ++ A + + + K A +QS YRG AR+ + L ++++Q+ R
Sbjct: 1608 AAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYR 1667
Query: 130 GHNVRKQAQMTMRCMQALVRVQARVRARRVQLSH-----------ECL-EKAMEEDEEEE 177
+ +K+ + A +++Q+ V+ ++ + + +C K + + EE
Sbjct: 1668 AYVSKKE---FLSLKNATIKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREE 1724
Query: 178 FVRQHETITK 187
+++ E+ K
Sbjct: 1725 YMQMRESCIK 1734
Score = 31.6 bits (70), Expect = 4.4
Identities = 17/49 (34%), Positives = 29/49 (58%), Gaps = 1/49 (2%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
++ RAA+ IQ R +L R+ G++++QAL RG++ RK+ T
Sbjct: 3179 SQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCT 3227
>ASPM_SAGLB (P62295) Abnormal spindle-like microcephaly-associated
protein homolog (Fragment)
Length = 1527
Score = 38.1 bits (87), Expect = 0.047
Identities = 34/142 (23%), Positives = 62/142 (42%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ V++Q+ RG++ R + Q +Q+++++Q
Sbjct: 395 KKAATCLQAAYRGYKVRQLIKQQSIAAVKIQSAFRGYSKRVRYQSV---LQSIIKIQRWY 451
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 452 RAYKTL-----------SDIRTHFLKTKAAVISLQSAYR----------GW--------K 482
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AAMK + A A
Sbjct: 483 VRKQIRREHQAAMKIQSAFRMA 504
Score = 35.0 bits (79), Expect = 0.40
Identities = 23/67 (34%), Positives = 39/67 (57%), Gaps = 8/67 (11%)
Query: 99 ATFIQSHYRGY-LARRA----LRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQAR 153
A FIQ HYR LA + ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 298 AVFIQQHYRSKKLAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRK---AVISLQSY 354
Query: 154 VRARRVQ 160
R R+ +
Sbjct: 355 YRMRKAR 361
Score = 31.6 bits (70), Expect = 4.4
Identities = 19/69 (27%), Positives = 34/69 (48%), Gaps = 1/69 (1%)
Query: 96 ERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
+ AA IQS YR ++ R+ +R + + +QA R H V ++ Q + + +
Sbjct: 905 QNAAIKIQSSYRRWMIRKRMREMHRAATFIQATFRMHRVHRRYQALKQASAMIQQQYQAN 964
Query: 155 RARRVQLSH 163
RA ++Q H
Sbjct: 965 RAAKLQRQH 973
Score = 31.2 bits (69), Expect = 5.8
Identities = 19/81 (23%), Positives = 44/81 (53%), Gaps = 2/81 (2%)
Query: 91 RHNKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNV-RKQAQMTMRCMQALV 148
R ++ + A IQS+YR ++ ++ + + K + +Q R +++ R+Q + + A+V
Sbjct: 559 RLQRQHKCAVIIQSYYRMHVQQKKWKTMKKAALLIQKYYRAYSIGREQHHLYLETKAAVV 618
Query: 149 RVQARVRARRVQLSHECLEKA 169
+Q+ R +V+ + +KA
Sbjct: 619 TLQSAYRGMKVRKRIKDCKKA 639
Score = 30.8 bits (68), Expect = 7.6
Identities = 26/128 (20%), Positives = 58/128 (45%), Gaps = 12/128 (9%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A V+ + A + + K A +QS YRG AR+ ++ ++++Q R
Sbjct: 201 AAVVIQTRFQAYIFARKVLASYQKTRSAVILLQSAYRGMQARKMYIQIPTSVIKIQPYYR 260
Query: 130 GHNVRKQ----AQMTMRCMQALVRVQ------ARVRARRVQLSHECLEKAMEEDEEEEFV 179
+ +K+ T++ +Q++V+++ +RA V + K + + EE++
Sbjct: 261 AYVSKKEFLSLKNATIK-LQSIVKMKQTRKQYLHLRATAVFIQQHYRSKKLAAQKREEYM 319
Query: 180 RQHETITK 187
+ E+ K
Sbjct: 320 QMRESCIK 327
>ASPM_PONPY (P62294) Abnormal spindle-like microcephaly-associated
protein homolog
Length = 3471
Score = 38.1 bits (87), Expect = 0.047
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ +++Q+ RG+N R + Q +Q+++++Q
Sbjct: 1796 KKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRIKYQSV---LQSIIKIQRWY 1852
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1853 RAYKTL-----------HDTRTHFLKTKAAVISLQSTYR----------GW--------K 1883
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AA+K + A A
Sbjct: 1884 VRKQIRREHQAALKIQSAFRMA 1905
Score = 37.0 bits (84), Expect = 0.11
Identities = 36/155 (23%), Positives = 76/155 (48%), Gaps = 25/155 (16%)
Query: 102 IQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQ-------AQMTMRCMQALVRVQAR 153
IQS+YR Y++++ +LK ++LQ++V+ RKQ A +C ++ ++ A+
Sbjct: 1656 IQSYYRAYVSKKEFLSLKNATIKLQSIVKVKQTRKQYLHLRAAALFIQQCYRS-KKIAAQ 1714
Query: 154 VRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVK 213
R +Q+ C++ + FVR + + K M R++ +S + ++
Sbjct: 1715 KREEYMQMRESCIKL-------QAFVRGYR-VRKQMRLQRKAVISLQS-------YFRMR 1759
Query: 214 KAKENDLRKHEAAMKRERALAYAFNYQQQQQKQHL 248
KA++ L+ ++A + + +A+ Q Q+K L
Sbjct: 1760 KARQYYLKMYKAIIVIQN-YYHAYKAQVNQRKNFL 1793
Score = 35.8 bits (81), Expect = 0.24
Identities = 21/71 (29%), Positives = 41/71 (57%), Gaps = 8/71 (11%)
Query: 91 RHNKEERAATFIQSHYRGYL-ARRAL----RALKGLVRLQALVRGHNVRKQAQMTMRCMQ 145
++ K ++AA IQ+H+R Y+ AR+ L + ++ LQ+ RG RK M + +
Sbjct: 1595 KYKKMKKAAVIIQTHFRAYIFARKVLASYQKTRSAVIVLQSAYRGMQARK---MYIHILT 1651
Query: 146 ALVRVQARVRA 156
+++++Q+ RA
Sbjct: 1652 SVIKIQSYYRA 1662
Score = 33.9 bits (76), Expect = 0.90
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 98 AATFIQSHYRG-----YLARRALRALKGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
AA FIQ YR ++ + ++LQA VRG+ VRKQ ++ + A++ +Q+
Sbjct: 1698 AALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYRVRKQMRLQRK---AVISLQS 1754
Query: 153 RVRARRVQLSHECLEKAM 170
R R+ + + + KA+
Sbjct: 1755 YFRMRKARQYYLKMYKAI 1772
Score = 33.5 bits (75), Expect = 1.2
Identities = 24/79 (30%), Positives = 39/79 (48%), Gaps = 11/79 (13%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNVRKQAQM-------TMRCMQ 145
K RA IQ+HYRGY R+ LR + +Q +R K+ ++ + +Q
Sbjct: 3022 KRHRATCLIQAHYRGYKGRQVFLRQKSAALVIQKYIRAREAGKRERIKYIEFKKSTVILQ 3081
Query: 146 ALVR---VQARVRARRVQL 161
ALVR V+ R+ +R ++
Sbjct: 3082 ALVRGWLVRKRILEQRAKI 3100
Score = 32.3 bits (72), Expect = 2.6
Identities = 17/49 (34%), Positives = 30/49 (60%), Gaps = 1/49 (2%)
Query: 93 NKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
+++ RAA+ IQ R +L R+ G++++QAL RG++ RK+ T
Sbjct: 3173 SQQNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCT 3221
Score = 30.8 bits (68), Expect = 7.6
Identities = 26/128 (20%), Positives = 58/128 (45%), Gaps = 12/128 (9%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A ++ A + + K A +QS YRG AR+ + L ++++Q+ R
Sbjct: 1602 AAVIIQTHFRAYIFARKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYR 1661
Query: 130 GHNVRKQ----AQMTMRCMQALVRVQ------ARVRARRVQLSHECLEKAMEEDEEEEFV 179
+ +K+ T++ +Q++V+V+ +RA + + K + + EE++
Sbjct: 1662 AYVSKKEFLSLKNATIK-LQSIVKVKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYM 1720
Query: 180 RQHETITK 187
+ E+ K
Sbjct: 1721 QMRESCIK 1728
>ASPM_FELCA (P62288) Abnormal spindle-like microcephaly-associated
protein homolog (Fragment)
Length = 3461
Score = 38.1 bits (87), Expect = 0.047
Identities = 36/178 (20%), Positives = 76/178 (42%), Gaps = 16/178 (8%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A ++ A V+ + K A +QS YRG ARR + L ++++Q+ R
Sbjct: 1609 AALIIQIHLRASVLAKRALASYQKTRSAVIVLQSAYRGMQARRKFIHILTSIIKIQSYYR 1668
Query: 130 GHNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPM 189
+ RK+ +R A V++Q+ V+ ++ + + L A F++Q K
Sbjct: 1669 AYISRKK---FLRLKHATVKLQSIVKMKQTRKQYLHLRAA------TLFIQQWYRSIKVA 1719
Query: 190 SPMRRSSVSSNNNNGWDNKCQSVKKAKENDLRKHEAAMKRERALAYAFNYQQQQQKQH 247
+ R V + C ++ L + + +R+ A++ ++ ++ +QH
Sbjct: 1720 ALKREEYVQMRES------CIKLQAFVRGHLVRKQMRSQRKAAVSLQSYFRMRKMRQH 1771
Score = 36.6 bits (83), Expect = 0.14
Identities = 21/69 (30%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Query: 94 KEERAATFIQSHYRGYLARRALRALKGLVRL-QALVRGHNV-RKQAQMTMRCMQALVRVQ 151
K+ + A IQS+YR ++ ++ +K RL Q R + + R+Q Q+ ++ A+V +Q
Sbjct: 1970 KQHKCAVIIQSYYRMHVQQKKWDIMKKAARLIQMYYRAYRIGRRQRQLYLKTKAAIVIIQ 2029
Query: 152 ARVRARRVQ 160
+ R+ RV+
Sbjct: 2030 SAYRSMRVR 2038
Score = 33.5 bits (75), Expect = 1.2
Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 9/79 (11%)
Query: 97 RAAT-FIQSHYRGYLARRALRA-----LKGLVRLQALVRGHNVRKQAQMTMRCMQALVRV 150
RAAT FIQ YR R + ++LQA VRGH VRKQ + + A V +
Sbjct: 1703 RAATLFIQQWYRSIKVAALKREEYVQMRESCIKLQAFVRGHLVRKQMRSQRK---AAVSL 1759
Query: 151 QARVRARRVQLSHECLEKA 169
Q+ R R+++ + + KA
Sbjct: 1760 QSYFRMRKMRQHYLEMYKA 1778
Score = 32.7 bits (73), Expect = 2.0
Identities = 30/108 (27%), Positives = 53/108 (48%), Gaps = 9/108 (8%)
Query: 93 NKEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMT----MRCMQAL 147
+++ RAA+ IQ R +L R+ + G+ ++QAL RG++ RK+ T +R L
Sbjct: 3180 SQQNRAASVIQKAVRRFLLRKKKEKINNGITKIQALWRGYSWRKKNDGTKIKAIRLSLQL 3239
Query: 148 VRVQARVR---ARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPM 192
V + R +R L+ CL E ++ E +T+ +SP+
Sbjct: 3240 VNREIREENKLYKRTALALHCLLTYKHLSAILEALKHLEVVTR-LSPL 3286
Score = 31.6 bits (70), Expect = 4.4
Identities = 38/126 (30%), Positives = 60/126 (47%), Gaps = 7/126 (5%)
Query: 65 ATAAAASAAVVAAQAAARVVRLA-GYGRHNKEERAATFIQSHYRGYLARRALRALK-GLV 122
A +A + AV+ Q++ R ++ G R + AAT IQS YR + A+ RA K +V
Sbjct: 2661 ALSAVRTQAVICIQSSYRGFKVRKGIQRMHL---AATLIQSLYRMHRAKLDYRAKKTAVV 2717
Query: 123 RLQALVRGHNVRKQAQMTMRCMQALVR-VQARVRARRVQLSHECLEKA-MEEDEEEEFVR 180
+Q R + K + +Q VR +QA R +V+ + L +A M E+
Sbjct: 2718 LIQYYYRSYVRVKTERKNFLALQKSVRIIQAAFRGMKVRQKLKNLSEAKMAAIEKRSAFC 2777
Query: 181 QHETIT 186
+H T T
Sbjct: 2778 RHRTET 2783
Score = 31.2 bits (69), Expect = 5.8
Identities = 37/124 (29%), Positives = 60/124 (47%), Gaps = 13/124 (10%)
Query: 72 AAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRG 130
AA+V Q+A R +R+ + + +AA IQS YR Y A++ + V +Q R
Sbjct: 2023 AAIVIIQSAYRSMRVRK--KIKEYNKAAVAIQSTYRAYKAKKNYATYRASAVLIQRWYRN 2080
Query: 131 HNV-RKQAQMTMRCMQALVRVQA-----RVRARRVQLSHECLE--KAMEEDEEEEFVRQH 182
+ +Q + + + V++QA RVR RR+Q H KAM + + + VR H
Sbjct: 2081 IKIANRQRKEYLNLKKTAVKIQAVFRGIRVR-RRIQHMHTAATFIKAMFKMHQAK-VRYH 2138
Query: 183 ETIT 186
+ T
Sbjct: 2139 KMRT 2142
>ASPM_CANFA (P62286) Abnormal spindle-like microcephaly-associated
protein homolog (Fragment)
Length = 3452
Score = 38.1 bits (87), Expect = 0.047
Identities = 22/69 (31%), Positives = 41/69 (58%), Gaps = 2/69 (2%)
Query: 94 KEERAATFIQSHYRGYLARRALRALKGLVRL-QALVRGHNV-RKQAQMTMRCMQALVRVQ 151
K+ + A IQS+YR Y+ ++ + +K RL Q R +++ RKQ Q+ ++ A V +Q
Sbjct: 1961 KQHKCAVIIQSNYRMYVQQKKWKIMKKAARLIQMYYRAYSIGRKQRQLYLKTKAAAVVLQ 2020
Query: 152 ARVRARRVQ 160
+ R+ +V+
Sbjct: 2021 SAYRSMKVR 2029
Score = 34.7 bits (78), Expect = 0.53
Identities = 25/91 (27%), Positives = 44/91 (47%), Gaps = 4/91 (4%)
Query: 71 SAAVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVR 129
+A V+ A V + K A +QS YRG AR+ + L ++++Q+ R
Sbjct: 1600 AALVIQIHFRAYVSAKKVLASYQKTRSAVLVLQSAYRGMQARKKFIHILTSIIKIQSCYR 1659
Query: 130 GHNVRKQAQMTMRCMQALVRVQARVRARRVQ 160
+ RK+ +R A V++Q+ V+ R+ Q
Sbjct: 1660 AYISRKR---FLRLKNATVKLQSIVKMRQTQ 1687
Score = 33.5 bits (75), Expect = 1.2
Identities = 28/104 (26%), Positives = 52/104 (49%), Gaps = 15/104 (14%)
Query: 102 IQSHYRGYLAR-RALRALKGLVRLQALVRGHNVRKQ------AQMTMRCMQALVRVQARV 154
IQS YR Y++R R LR V+LQ++V+ +K+ A + ++ ++ A
Sbjct: 1654 IQSCYRAYISRKRFLRLKNATVKLQSIVKMRQTQKRYLHWRAASLFIQRWYRSAKLAALK 1713
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVS 198
R + VQ+ C++ + FVR H + K + R++++S
Sbjct: 1714 RHQYVQMRESCIKL-------QAFVRGH-LVRKQIRLQRQAAIS 1749
Score = 33.1 bits (74), Expect = 1.5
Identities = 26/70 (37%), Positives = 35/70 (49%), Gaps = 16/70 (22%)
Query: 98 AATFIQSHYRGYLARRALRALK---------GLVRLQALVRGHNVRKQAQMTMRCMQALV 148
A+ FIQ YR L ALK ++LQA VRGH VRKQ ++ QA +
Sbjct: 1696 ASLFIQRWYRS----AKLAALKRHQYVQMRESCIKLQAFVRGHLVRKQIRLQ---RQAAI 1748
Query: 149 RVQARVRARR 158
+Q+ R R+
Sbjct: 1749 SLQSYFRMRK 1758
Score = 33.1 bits (74), Expect = 1.5
Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 73 AVVAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRALRALKGLVR-LQALVRGH 131
A+ QA+ R R+ R K E AAT IQS+YR + + LK + R +Q R
Sbjct: 2161 AITVLQASFRGTRVGQTLR--KMESAATLIQSYYRRHRQQAYFTKLKKVTRTIQQRYRAV 2218
Query: 132 NVRK-QAQMTMRCMQALVRVQARVRARRVQ 160
R Q Q + +++R+QA R + +
Sbjct: 2219 KERNTQLQRYNKLRHSIIRIQAGFRGMKAR 2248
Score = 31.6 bits (70), Expect = 4.4
Identities = 28/101 (27%), Positives = 45/101 (43%), Gaps = 12/101 (11%)
Query: 78 QAAARVVRLAGYGRHNKE----ERAATFIQSHYRGYLARRALRA-----LKGLVRLQALV 128
QAA R+ + K+ + AA IQ H R + A + R + +RLQ+
Sbjct: 1891 QAAVRIQSAFRMAKAQKQFKLLKTAALVIQQHLRAWTAGKRQRMEYIELREAALRLQSTW 1950
Query: 129 RGHNVRKQAQMTMRCMQALVRVQARVRARRVQLSHECLEKA 169
+G VR+Q Q +C V +Q+ R Q + ++KA
Sbjct: 1951 KGKRVRRQVQKQHKC---AVIIQSNYRMYVQQKKWKIMKKA 1988
Score = 30.4 bits (67), Expect = 9.9
Identities = 19/87 (21%), Positives = 45/87 (50%), Gaps = 8/87 (9%)
Query: 75 VAAQAAARVVRLAGYGRHNKEERAATFIQSHYRGYLARRAL-----RALKGLVRLQALVR 129
+ + A+V + ++ K ++AA IQ H+R Y++ + + + ++ LQ+ R
Sbjct: 1577 ITTKLQAQVRKHQQLQKYRKIKKAALVIQIHFRAYVSAKKVLASYQKTRSAVLVLQSAYR 1636
Query: 130 GHNVRKQAQMTMRCMQALVRVQARVRA 156
G RK+ + + +++++Q+ RA
Sbjct: 1637 GMQARKK---FIHILTSIIKIQSCYRA 1660
>ASPM_AOTVO (P62283) Abnormal spindle-like microcephaly-associated
protein homolog
Length = 3473
Score = 37.7 bits (86), Expect = 0.062
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 33/142 (23%)
Query: 96 ERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
++AAT +Q+ YRGY R+ ++ V++Q+ RG+ R + Q +Q+++++Q
Sbjct: 1798 KKAATCLQAAYRGYKVRQLIKQQSIAAVKIQSAFRGYRKRVKYQSV---LQSIIKIQRWY 1854
Query: 155 RARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVKK 214
RA + D F++ + S R GW K
Sbjct: 1855 RAYKTL-----------SDIRTHFLKTKAAVISLQSAYR----------GW--------K 1885
Query: 215 AKENDLRKHEAAMKRERALAYA 236
++ R+H+AAMK + A A
Sbjct: 1886 VRKQIRREHQAAMKIQSAFRMA 1907
Score = 35.0 bits (79), Expect = 0.40
Identities = 36/155 (23%), Positives = 75/155 (48%), Gaps = 25/155 (16%)
Query: 102 IQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQ-------AQMTMRCMQALVRVQAR 153
IQS+YR Y++++ +LK V+LQ++V+ RKQ RC ++ ++ A+
Sbjct: 1658 IQSYYRAYVSKKEFLSLKNATVKLQSIVKMKQTRKQYLHLRATVLFIQRCYRS-KKLAAQ 1716
Query: 154 VRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSVK 213
R +Q+ C++ + FVR + + K M R++ +S + ++
Sbjct: 1717 KREEYMQMRESCIKL-------QAFVRGY-LVRKQMRLQRKAVISLQS-------YFRMR 1761
Query: 214 KAKENDLRKHEAAMKRERALAYAFNYQQQQQKQHL 248
KA++ L+ ++A + + +++ Q Q+K L
Sbjct: 1762 KARQYYLKMYKAVIIIQN-YYHSYKAQVNQRKNFL 1795
Score = 34.3 bits (77), Expect = 0.69
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 88 GYGRHNKEERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMT 140
G R +++ RAA+ IQ R +L RR G+++ QAL RG++ RK T
Sbjct: 3170 GQERLSQQNRAASVIQKAVRHFLLRRKQEKFTSGIIKFQALWRGYSWRKNNDCT 3223
Score = 32.0 bits (71), Expect = 3.4
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 94 KEERAATFIQSHYRGYLARRA-LRALKGLVRLQALVRGHNV-RKQAQMTMRCMQALVRVQ 151
+ RAA IQ+H+RGY R+ LR + +Q +R R++ + ++ V +Q
Sbjct: 3024 QRHRAACLIQAHFRGYKGRQVFLRQKSAALNIQKYIRAREAGRRERIKYIELKKSTVILQ 3083
Query: 152 ARVR 155
A VR
Sbjct: 3084 ALVR 3087
Score = 30.4 bits (67), Expect = 9.9
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)
Query: 96 ERAATFIQSHYRGYLARRALRAL-KGLVRLQALVRGHNVRKQAQMTMRCMQALVRVQARV 154
+ AA IQS YR ++ R+ +R + + +QA R H V + Q + + +
Sbjct: 2308 QNAAIKIQSSYRRWMIRKKIREMHRAATFIQATFRMHRVHMRYQALKQASVVIQQQYQAN 2367
Query: 155 RARRVQLSH 163
RA ++Q H
Sbjct: 2368 RAAKLQRQH 2376
>MY5C_HUMAN (Q9NQX4) Myosin Vc (Myosin 5C)
Length = 1742
Score = 37.0 bits (84), Expect = 0.11
Identities = 33/154 (21%), Positives = 68/154 (43%), Gaps = 12/154 (7%)
Query: 94 KEERAATFIQSHYRGYLARRALRALK-GLVRLQALVRGHNVRKQAQMTMRCMQALVRVQA 152
KE AA IQ H RGYL R + ++ + +QA RG R++ + + +A++ +Q
Sbjct: 806 KEAWAAIIIQKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVI-LQK 864
Query: 153 RVRARRVQLSHECLEKAMEEDEEEEFVRQHETITKPMSPMRRSSVSSNNNNGWDNKCQSV 212
RA + + + + FV + + ++ + N+G K S+
Sbjct: 865 YARAWLARRRFQSIRR---------FVLNIQLTYRVQRLQKKLEDQNKENHGLVEKLTSL 915
Query: 213 KKAKENDLRK-HEAAMKRERALAYAFNYQQQQQK 245
+ D+ K + + E+A + NY+++ ++
Sbjct: 916 AALRAGDVEKIQKLEAELEKAATHRRNYEEKGKR 949
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.314 0.127 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,069,465
Number of Sequences: 164201
Number of extensions: 2302102
Number of successful extensions: 11334
Number of sequences better than 10.0: 116
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 10805
Number of HSP's gapped (non-prelim): 544
length of query: 458
length of database: 59,974,054
effective HSP length: 114
effective length of query: 344
effective length of database: 41,255,140
effective search space: 14191768160
effective search space used: 14191768160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Medicago: description of AC149127.2