BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC148817.11 - phase: 0 
         (276 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

DHCA_RAT (P47727) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (N...   148  2e-35
DHCA_MOUSE (P48758) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) ...   144  2e-34
DHCA_HUMAN (P16152) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) ...   139  1e-32
DHCA_RABIT (P47844) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) ...   132  7e-31
DHC3_HUMAN (O75828) Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) ...   130  3e-30
DHCA_PIG (Q28960) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (N...   128  1e-29
DHKR_STRCM (P41177) Monensin polyketide synthase putative ketoac...    73  7e-13
YUSZ_BACSU (P37959) Hypothetical oxidoreductase yusZ (EC 1.-.-.-...    72  1e-12
FABG_AQUAE (O67610) 3-oxoacyl-[acyl-carrier-protein] reductase (...    72  1e-12
FABG_ECOLI (P25716) 3-oxoacyl-[acyl-carrier-protein] reductase (...    72  1e-12
RDHC_HUMAN (Q96NR8) Retinol dehydrogenase 12 (EC 1.1.1.-)              72  2e-12
FABG_BACSU (P51831) 3-oxoacyl-[acyl-carrier-protein] reductase (...    70  7e-12
FABG_SALTY (O85141) 3-oxoacyl-[acyl-carrier-protein] reductase (...    69  1e-11
YIM4_YEAST (P40471) Hypothetical oxidoreductase in KGD1-SIM1 int...    68  2e-11
Y484_MYCTU (Q11150) Putative oxidoreductase Rv0484c/MT0502 (EC 1...    68  2e-11
YXBG_BACSU (P46331) Hypothetical oxidoreductase yxbG (EC 1.-.-.-)      67  4e-11
FABG_CHLMU (Q9PKF7) 3-oxoacyl-[acyl-carrier-protein] reductase (...    67  4e-11
DHK1_STRVN (P16542) Granaticin polyketide synthase putative keto...    67  5e-11
RDHC_MOUSE (Q8BYK4) Retinol dehydrogenase 12 (EC 1.1.1.-)              65  2e-10
YOXD_BACSU (P14802) Hypothetical oxidoreductase yoxD (EC 1.-.-.-)      64  3e-10

>DHCA_RAT (P47727) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184)
           (NADPH-dependent carbonyl reductase 1)
          Length = 276

 Score =  148 bits (373), Expect = 2e-35
 Identities = 104/277 (37%), Positives = 158/277 (56%), Gaps = 21/277 (7%)

Query: 8   AVVTGANKGIGYGICKKLASSGVV-VVLTARNEERGLEAVERLKNEFDFSDFVVFHQLDV 66
           A+VTGANKGIG+ I + L    +  VVLTAR+E RG EAV++L+ E        FHQLD+
Sbjct: 7   ALVTGANKGIGFAIVRDLCRKFLGDVVLTARDESRGHEAVKQLQTE---GLSPRFHQLDI 63

Query: 67  DDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERVTE 126
           D+P S+ +L  F+   +G L++LVNNAG+   K++D      + E  +KTNF+G + V +
Sbjct: 64  DNPQSIRALRDFLLQEYGGLNVLVNNAGI-AFKVVDPTPFHIQAEVTMKTNFFGTQDVCK 122

Query: 127 ALVPLLQLSTSPTIVNVSSRAGL--LKNISNEWARIVFNDIENLTKEKIDEVLKEFEKDY 184
            L+P+++      +VNVSS   L  LK+ S E  +   +  E +T+E++  ++ +F +D 
Sbjct: 123 ELLPIIK--PQGRVVNVSSSVSLRALKSCSPELQQKFRS--ETITEEELVGLMNKFIEDA 178

Query: 185 KEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKY------PHFHINSVCPGFVKTDMNN 238
           K+G    + WP   SAY ++K  +   +RI A+K           +N+ CPG+V+TDM  
Sbjct: 179 KKGVHAKEGWPN--SAYGVTKIGVTVLSRIYARKLNEERREDKILLNACCPGWVRTDMAG 236

Query: 239 NIGNLSIDEGVETPLMLALW--SNNGPSGCFFNKGEV 273
                S +EG ETP+ LAL      GP G F    +V
Sbjct: 237 PKATKSPEEGAETPVYLALLPPGAEGPHGQFVQDKKV 273


>DHCA_MOUSE (P48758) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184)
           (NADPH-dependent carbonyl reductase 1)
          Length = 276

 Score =  144 bits (363), Expect = 2e-34
 Identities = 104/280 (37%), Positives = 155/280 (55%), Gaps = 27/280 (9%)

Query: 8   AVVTGANKGIGYGI----CKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQ 63
           A+VTGANKGIG+ I    C+K +     VVL AR+EERG  AV++L+ E        FHQ
Sbjct: 7   ALVTGANKGIGFAITRDLCRKFSGD---VVLAARDEERGQTAVQKLQAE---GLSPRFHQ 60

Query: 64  LDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVER 123
           LD+D+P S+ +L  F+   +G LD+LVN AG+   K+ D      + E  ++TNF+G   
Sbjct: 61  LDIDNPQSIRALRDFLLKEYGGLDVLVNKAGI-AFKVNDDTPFHIQAEVTMETNFFGTRD 119

Query: 124 VTEALVPLLQLSTSPTIVNVSSRAGL--LKNISNEWARIVFNDIENLTKEKIDEVLKEFE 181
           V + L+PL++      +VNVSS   L  LKN   E  +   +  E +T+E++  ++ +F 
Sbjct: 120 VCKELLPLIK--PQGRVVNVSSMVSLRALKNCRLELQQKFRS--ETITEEELVGLMNKFV 175

Query: 182 KDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKY------PHFHINSVCPGFVKTD 235
           +D K+G    + WP   SAY ++K  +   +RI+A+K           +N+ CPG+V+TD
Sbjct: 176 EDTKKGVHAEEGWPN--SAYGVTKIGVTVLSRILARKLNEQRREDKILLNACCPGWVRTD 233

Query: 236 MNNNIGNLSIDEGVETPLMLALW--SNNGPSGCFFNKGEV 273
           M       S +EG ETP+ LAL      GP G F    +V
Sbjct: 234 MAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKV 273


>DHCA_HUMAN (P16152) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184)
           (NADPH-dependent carbonyl reductase 1)
           (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)
           (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin
           dehydrogenase [NADP+]) (EC 1.1.1.197)
          Length = 276

 Score =  139 bits (349), Expect = 1e-32
 Identities = 104/278 (37%), Positives = 155/278 (55%), Gaps = 23/278 (8%)

Query: 8   AVVTGANKGIGYGICKKLAS--SGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           A+VTG NKGIG  I + L    SG VV LTAR+  RG  AV++L+ E        FHQLD
Sbjct: 7   ALVTGGNKGIGLAIVRDLCRLFSGDVV-LTARDVTRGQAAVQQLQAE---GLSPRFHQLD 62

Query: 66  VDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERVT 125
           +DD  S+ +L  F++  +G LD+LVNNAG+   K+ D      + E  +KTNF+G   V 
Sbjct: 63  IDDLQSIRALRDFLRKEYGGLDVLVNNAGI-AFKVADPTPFHIQAEVTMKTNFFGTRDVC 121

Query: 126 EALVPLLQLSTSPTIVNVSSRAGL--LKNISNEWARIVFNDIENLTKEKIDEVLKEFEKD 183
             L+PL++      +VNVSS   +  LK+ S E  +   +  E +T+E++  ++ +F +D
Sbjct: 122 TELLPLIK--PQGRVVNVSSIMSVRALKSCSPELQQKFRS--ETITEEELVGLMNKFVED 177

Query: 184 YKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPH------FHINSVCPGFVKTDMN 237
            K+G  + + WP  +SAY ++K  +   +RI A+K           +N+ CPG+V+TDM 
Sbjct: 178 TKKGVHQKEGWP--SSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMA 235

Query: 238 NNIGNLSIDEGVETPLMLALW--SNNGPSGCFFNKGEV 273
                 S +EG ETP+ LAL      GP G F ++  V
Sbjct: 236 GPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRV 273


>DHCA_RABIT (P47844) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184)
           (NADPH-dependent carbonyl reductase 1)
          Length = 276

 Score =  132 bits (333), Expect = 7e-31
 Identities = 100/274 (36%), Positives = 152/274 (54%), Gaps = 23/274 (8%)

Query: 6   RYAVVTGANKGIGYGICKKLAS--SGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQ 63
           R A+VTGANKG+G+ I + L    SG V+ LTA++E +G  AV++L+ E        FHQ
Sbjct: 5   RVALVTGANKGVGFAITRALCRLFSGDVL-LTAQDEAQGQAAVQQLQAE---GLSPRFHQ 60

Query: 64  LDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVER 123
           LD+ D  S+ +L  F++  +G L++LVNNA V   K+ D      + E  +KTNF G   
Sbjct: 61  LDITDLQSIRALRDFLRRAYGGLNVLVNNA-VIAFKMEDTTPFHIQAEVTMKTNFDGTRD 119

Query: 124 VTEALVPLLQLSTSPTIVNVSSRAGL--LKNISNEWARIVFNDIENLTKEKIDEVLKEFE 181
           V   L+PL++      +VNVSS   L  LK+ S E  +   +  E +T+E++  ++K+F 
Sbjct: 120 VCTELLPLMR--PGGRVVNVSSMTCLRALKSCSPELQQKFRS--ETITEEELVGLMKKFV 175

Query: 182 KDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPHFH------INSVCPGFVKTD 235
           +D K+G  + + WP   +AY ++K  +   +RI A+            +N+ CPG+V+TD
Sbjct: 176 EDTKKGVHQTEGWPD--TAYGVTKMGVTVLSRIQARHLSEHRGGDKILVNACCPGWVRTD 233

Query: 236 MNNNIGNLSIDEGVETPLMLALW--SNNGPSGCF 267
           M       S +EG ETP+ LAL      GP G F
Sbjct: 234 MGGPNATKSPEEGAETPVYLALLPPDAEGPHGQF 267


>DHC3_HUMAN (O75828) Carbonyl reductase [NADPH] 3 (EC 1.1.1.184)
           (NADPH-dependent carbonyl reductase 3)
          Length = 276

 Score =  130 bits (327), Expect = 3e-30
 Identities = 95/261 (36%), Positives = 142/261 (54%), Gaps = 19/261 (7%)

Query: 6   RYAVVTGANKGIGYGICKKLASS-GVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQL 64
           R A+VTGAN+GIG  I ++L       VVLTAR+  RG  AV++L+ E        FHQL
Sbjct: 5   RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE---GLSPRFHQL 61

Query: 65  DVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERV 124
           D+DD  S+ +L  F++  +G L++LVNNA V   K  D      K E  LKTNF+    +
Sbjct: 62  DIDDLQSIRALRDFLRKEYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATRNM 120

Query: 125 TEALVPLLQLSTSPTIVNVSSRAGL--LKNISNEWARIVFNDIENLTKEKIDEVLKEFEK 182
              L+P+++      +VN+SS   L   +N S +      +  E LT+  + +++K+F +
Sbjct: 121 CNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHS--ETLTEGDLVDLMKKFVE 176

Query: 183 DYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMA------KKYPHFHINSVCPGFVKTDM 236
           D K    E + WP   S Y +SK  +   +RI+A      +K     +N+ CPG VKTDM
Sbjct: 177 DTKNEVHEREGWPN--SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 234

Query: 237 NNNIGNLSIDEGVETPLMLAL 257
           +      +++EG ETP+ LAL
Sbjct: 235 DGKDSIRTVEEGAETPVYLAL 255


>DHCA_PIG (Q28960) Carbonyl reductase [NADPH] 1 (EC 1.1.1.184)
           (NADPH-dependent carbonyl reductase 1)
           (20-beta-hydroxysteroid dehydrogenase)
           (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)
           (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin
           dehydroge
          Length = 288

 Score =  128 bits (322), Expect = 1e-29
 Identities = 99/285 (34%), Positives = 152/285 (52%), Gaps = 27/285 (9%)

Query: 6   RYAVVTGANKGIGYGI----CKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVF 61
           R A+VTGANKGIG+ I    C++ A     VVLTAR+  RG  AV++L+ E        F
Sbjct: 5   RVALVTGANKGIGFAIVRDLCRQFAGD---VVLTARDVARGQAAVKQLQAE---GLSPRF 58

Query: 62  HQLDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGV 121
           HQLD+ D  S+ +L  F++  +G LD+LVNNA +   +L +      + E  +KTNF G 
Sbjct: 59  HQLDIIDLQSIRALCDFLRKEYGGLDVLVNNAAI-AFQLDNPTPFHIQAELTMKTNFMGT 117

Query: 122 ERVTEALVPLLQLSTSPTIVNVSSRAGL--LKNISNEWARIVFNDIENLTKEKIDEVLKE 179
             V   L+PL++      +VNVSS  G+  L   S E  +   +  E +T+E++  ++ +
Sbjct: 118 RNVCTELLPLIK--PQGRVVNVSSTEGVRALNECSPELQQKFKS--ETITEEELVGLMNK 173

Query: 180 FEKDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKY------PHFHINSVCPGFVK 233
           F +D K G    + W    S Y ++K  ++  +RI A+K           +N+ CPG+V+
Sbjct: 174 FVEDTKNGVHRKEGWSD--STYGVTKIGVSVLSRIYARKLREQRAGDKILLNACCPGWVR 231

Query: 234 TDMNNNIGNLSIDEGVETPLMLALWSNN--GPSGCFFNKGEVISF 276
           TDM       S + G ETP+ LAL  ++  GP G F    +V+ +
Sbjct: 232 TDMGGPKAPKSPEVGAETPVYLALLPSDAEGPHGQFVTDKKVVEW 276


>DHKR_STRCM (P41177) Monensin polyketide synthase putative ketoacyl
           reductase (EC 1.3.1.-) (ORF5)
          Length = 261

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 65/239 (27%), Positives = 101/239 (42%), Gaps = 51/239 (21%)

Query: 6   RYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           R A+VTGA  GIG    + LA+ G +V L AR E   +  V+ L+N+   ++  V   LD
Sbjct: 7   RVALVTGATSGIGLATARLLAAQGHLVFLGARTESDVIATVKALRNDGLEAEGQV---LD 63

Query: 66  VDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERVT 125
           V D ASV +        +G++D+LVNNAG  GG  +  D      +  + TN   V R+T
Sbjct: 64  VRDGASVTAFVQAAVDRYGRIDVLVNNAGRSGGG-VTADLTDELWDDVIDTNLNSVFRMT 122

Query: 126 EALVPLLQLSTSP--TIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLKEFEKD 183
            A++    + T     I+NV+S AG                                   
Sbjct: 123 RAVLTTGGMRTRERGRIINVASTAG----------------------------------- 147

Query: 184 YKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKY--PHFHINSVCPGFVKTDMNNNI 240
                   K      + Y+ SK  +  +T+ +  +       +N+VCPG+V+T M   +
Sbjct: 148 --------KQGVVLGAPYSASKHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRV 198


>YUSZ_BACSU (P37959) Hypothetical oxidoreductase yusZ (EC 1.-.-.-)
           (ORFA)
          Length = 280

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 49/144 (34%), Positives = 75/144 (52%), Gaps = 4/144 (2%)

Query: 6   RYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           + A+VTGA+ G G     KLA S   V+ T+R  E+  E +  L    + SD +    LD
Sbjct: 4   KIAIVTGASSGFGLLAAVKLARS-FFVIATSRQPEKA-EQLRELAAAHNVSDSIHITALD 61

Query: 66  VDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERVT 125
           V D  S+ S    +   +  +D+LVNNAG   G  I+ D  +    +  +TN +GV  VT
Sbjct: 62  VTDEQSIVSFGKAVSA-YAPIDLLVNNAGTAYGGFIE-DVPMEHFRQQFETNVFGVIHVT 119

Query: 126 EALVPLLQLSTSPTIVNVSSRAGL 149
           + ++P ++      I+NVSS +GL
Sbjct: 120 KTVLPYIRKHGGAKIINVSSISGL 143


>FABG_AQUAE (O67610) 3-oxoacyl-[acyl-carrier-protein] reductase (EC
           1.1.1.100) (3-ketoacyl-acyl carrier protein reductase)
          Length = 248

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 63/238 (26%), Positives = 103/238 (42%), Gaps = 48/238 (20%)

Query: 1   MKFVFRYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVV 60
           +K   + ++VTG+ +GIG  I +KLAS+G  V++T  + ER     E + N++      V
Sbjct: 3   IKLQGKVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGV 62

Query: 61  FHQLDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYG 120
             ++++    S+      I  +   +DILVNNAG+   KL    +LL   E+ LK N  G
Sbjct: 63  --EMNLLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLL-DWEEVLKVNLTG 119

Query: 121 VERVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLKEF 180
              VT+  +  +       IVN+SS  G   N+                           
Sbjct: 120 TFLVTQNSLRKMIKQRWGRIVNISSVVGFTGNVGQ------------------------- 154

Query: 181 EKDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYP--HFHINSVCPGFVKTDM 236
                               Y+ +KA L  +T+ +AK+    +  +N+V PGF++TDM
Sbjct: 155 ------------------VNYSTTKAGLIGFTKSLAKELAPRNVLVNAVAPGFIETDM 194


>FABG_ECOLI (P25716) 3-oxoacyl-[acyl-carrier-protein] reductase (EC
           1.1.1.100) (3-ketoacyl-acyl carrier protein reductase)
          Length = 244

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 65/252 (25%), Positives = 112/252 (43%), Gaps = 68/252 (26%)

Query: 1   MKFVFRYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVV 60
           M F  + A+VTGA++GIG  I + LA+ G  V+ TA +E  G +A+         SD++ 
Sbjct: 1   MNFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSEN-GAQAI---------SDYLG 50

Query: 61  FH----QLDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEK---- 112
            +     L+V DPAS+ S+   I+  FG++DILVNNAG+    L     L+R  ++    
Sbjct: 51  ANGKGLMLNVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNL-----LMRMKDEEWND 105

Query: 113 CLKTNFYGVERVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEK 172
            ++TN   V R+++A++  +       I+ + S  G + N                    
Sbjct: 106 IIETNLSSVFRLSKAVMRAMMKKRHGRIITIGSVVGTMGNGGQ----------------- 148

Query: 173 IDEVLKEFEKDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPH--FHINSVCPG 230
                                     + Y  +KA L  +++ +A++       +N V PG
Sbjct: 149 --------------------------ANYAAAKAGLIGFSKSLAREVASRGITVNVVAPG 182

Query: 231 FVKTDMNNNIGN 242
           F++TDM   + +
Sbjct: 183 FIETDMTRALSD 194


>RDHC_HUMAN (Q96NR8) Retinol dehydrogenase 12 (EC 1.1.1.-)
          Length = 316

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 79/282 (28%), Positives = 123/282 (43%), Gaps = 56/282 (19%)

Query: 6   RYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           +  V+TGAN GIG    ++LAS G  V +  R+  +G  A   ++ +   S  V+  +LD
Sbjct: 40  KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQ-VLVRKLD 98

Query: 66  VDDPASVASLASFIKTMFGKLDILVNNAGV---PGGKLIDGDALLRKVEKCLKTNFYGVE 122
           + D  S+ + A        +L IL+NNAGV   P  K  DG       E  L  N  G  
Sbjct: 99  LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADG------FETHLGVNHLGHF 152

Query: 123 RVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLKEFEK 182
            +T  L+  L++S    +VNVSS       +++   +I F+D+++             EK
Sbjct: 153 LLTYLLLEQLKVSAPARVVNVSS-------VAHHIGKIPFHDLQS-------------EK 192

Query: 183 DYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPHFHIN--SVCPGFVKTDMNNNI 240
            Y  G            AY  SK A   +TR +AK+     +   +V PG V++++  + 
Sbjct: 193 RYSRG-----------FAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHS 241

Query: 241 GNLSI------------DEGVETPLMLALWSNNGP-SGCFFN 269
             L +             EG +T L  AL     P SG +F+
Sbjct: 242 SLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFS 283


>FABG_BACSU (P51831) 3-oxoacyl-[acyl-carrier-protein] reductase (EC
           1.1.1.100) (3-ketoacyl-acyl carrier protein reductase)
          Length = 246

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 66/247 (26%), Positives = 102/247 (40%), Gaps = 58/247 (23%)

Query: 8   AVVTGANKGIGYGICKKLASSGV-VVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLDV 66
           A+VTGA++GIG  I   LA SG  VVV  + NE +  E V+ +K+        +  + DV
Sbjct: 7   AIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANEVVDEIKS---MGRKAIAVKADV 63

Query: 67  DDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVE----KCLKTNFYGVE 122
            +P  V ++     ++F  +DILVNNAG+    LI     +R  E      +  N  GV 
Sbjct: 64  SNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLI-----MRMKEDEWDDVININLKGVF 118

Query: 123 RVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLKEFEK 182
             T+A+   +    S  I+NVSS  G+  N                              
Sbjct: 119 NCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQ--------------------------- 151

Query: 183 DYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYP--HFHINSVCPGFVKTDMNNNI 240
                           + Y  +KA +   T+  AK+    +  +N++ PGF+ TDM + +
Sbjct: 152 ----------------ANYVAAKAGVIGLTKSSAKELASRNITVNAIAPGFISTDMTDKL 195

Query: 241 GNLSIDE 247
                DE
Sbjct: 196 AKDVQDE 202


>FABG_SALTY (O85141) 3-oxoacyl-[acyl-carrier-protein] reductase (EC
           1.1.1.100) (3-ketoacyl-acyl carrier protein reductase)
          Length = 244

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 65/253 (25%), Positives = 109/253 (42%), Gaps = 70/253 (27%)

Query: 1   MKFVFRYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVV 60
           M F  + A+VTGA++GIG  I + L + G  V+ TA +E          KN    SD++ 
Sbjct: 1   MSFEGKIALVTGASRGIGRAIAETLVARGAKVIGTATSENGA-------KN---ISDYLG 50

Query: 61  FH----QLDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVE----- 111
            +     L+V DPAS+ S+   I+  FG++DILVNNAG      I  D LL +++     
Sbjct: 51  ANGKGLMLNVTDPASIESVLENIRAEFGEVDILVNNAG------ITRDNLLMRMKDDEWN 104

Query: 112 KCLKTNFYGVERVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKE 171
             ++TN   V R+++A++  +       I+ + S  G + N                   
Sbjct: 105 DIIETNLSSVFRLSKAVMRAMMKKRCGRIITIGSVVGTMGNAGQ---------------- 148

Query: 172 KIDEVLKEFEKDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPH--FHINSVCP 229
                                      + Y  +KA L  +++ +A++       +N V P
Sbjct: 149 ---------------------------ANYAAAKAGLIGFSKSLAREVASRGITVNVVAP 181

Query: 230 GFVKTDMNNNIGN 242
           GF++TDM   + +
Sbjct: 182 GFIETDMTRALSD 194


>YIM4_YEAST (P40471) Hypothetical oxidoreductase in KGD1-SIM1
           intergenic region (EC 1.-.-.-)
          Length = 297

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 51/147 (34%), Positives = 77/147 (51%), Gaps = 9/147 (6%)

Query: 6   RYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           + AVVTGA+ GIGY + K+LA +G +V   AR     LE + +L  +F  +D +  ++LD
Sbjct: 10  KIAVVTGASGGIGYEVTKELARNGYLVYACARR----LEPMAQLAIQFG-NDSIKPYKLD 64

Query: 66  VDDPASVASLASFIKTMF--GKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVER 123
           +  P  + + + F++     GKLD+L NNAG         DA    VE+C K N +G   
Sbjct: 65  ISKPEEIVTFSGFLRANLPDGKLDLLYNNAG-QSCTFPALDATDAAVEQCFKVNVFGHIN 123

Query: 124 VTEALVPLLQLSTSPTIVNVSSRAGLL 150
           +   L   L +    TIV   S AG++
Sbjct: 124 MCRELSEFL-IKAKGTIVFTGSLAGVV 149


>Y484_MYCTU (Q11150) Putative oxidoreductase Rv0484c/MT0502 (EC
           1.-.-.-)
          Length = 251

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 55/144 (38%), Positives = 71/144 (49%), Gaps = 12/144 (8%)

Query: 6   RYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           R AVVTGA+ GIG    + LA+ G  VV  AR  +R    +  L N+   +  V     D
Sbjct: 9   RVAVVTGASSGIGEATARTLAAQGFHVVAVARRADR----ITALANQIGGTAIVA----D 60

Query: 66  VDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERVT 125
           V D A+V +LA  +     ++D+LVNNAG   G     DA L        TN  G  RVT
Sbjct: 61  VTDDAAVEALARALS----RVDVLVNNAGGAKGLQFVADADLEHWRWMWDTNVLGTLRVT 116

Query: 126 EALVPLLQLSTSPTIVNVSSRAGL 149
            AL+P L  S    IV V+S A +
Sbjct: 117 RALLPKLIDSGDGLIVTVTSIAAI 140


>YXBG_BACSU (P46331) Hypothetical oxidoreductase yxbG (EC 1.-.-.-)
          Length = 273

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 53/165 (32%), Positives = 83/165 (50%), Gaps = 8/165 (4%)

Query: 8   AVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLDVD 67
           AV+TGA  GIG    +  A+ G  V++   N+++  E V+ ++     ++   FH LDV 
Sbjct: 9   AVITGAATGIGQATAEVFANEGARVIIGDINKDQMEETVDAIRKNGGQAES--FH-LDVS 65

Query: 68  DPASVASLASFIKTMFGKLDILVNNAGV--PGGKLIDGDALLRKVEKCLKTNFYGVERVT 125
           D  SV + A  IK   G +DIL NNAGV   GGK+ +    L   ++ +  +  G    +
Sbjct: 66  DENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYPVDL--FDRIIAVDLRGTFLCS 123

Query: 126 EALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTK 170
           + L+PL+ L    +I+N SS +G   ++           I NLTK
Sbjct: 124 KYLIPLM-LENGGSIINTSSMSGRAADLDRSGYNAAKGGITNLTK 167


>FABG_CHLMU (Q9PKF7) 3-oxoacyl-[acyl-carrier-protein] reductase (EC
           1.1.1.100) (3-ketoacyl-acyl carrier protein reductase)
          Length = 248

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 61/246 (24%), Positives = 103/246 (41%), Gaps = 58/246 (23%)

Query: 4   VFRYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQ 63
           V + A+VTG ++GIG+GI K  A  G  V +   NEE G  A + L ++      V F  
Sbjct: 6   VNKAAIVTGGSRGIGFGIAKLFAEHGANVQIWGINEEAGKSAAQDLSDK--TGSKVSFAL 63

Query: 64  LDVDDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEK-----CLKTNF 118
           +DV     V++        +G +D++VNNAG      I  D+LL ++ +      + TN 
Sbjct: 64  VDVSKNDMVSAQVQKFLAEYGTIDVVVNNAG------ITRDSLLMRMSEEEWSSVIDTNL 117

Query: 119 YGVERVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLK 178
             +  V  A++  +  + S  IVN+SS  GL                             
Sbjct: 118 GSIYNVCSAVIRPMIKARSGAIVNISSIVGL----------------------------- 148

Query: 179 EFEKDYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKY--PHFHINSVCPGFVKTDM 236
                   GS          + Y  +KA +  +++ ++K+    +  +N + PGF+ TDM
Sbjct: 149 -------RGS-------PGQTNYAAAKAGIIGFSKALSKEVGSKNIRVNCIAPGFIDTDM 194

Query: 237 NNNIGN 242
              + +
Sbjct: 195 TKGLSD 200


>DHK1_STRVN (P16542) Granaticin polyketide synthase putative
           ketoacyl reductase 1 (EC 1.3.1.-) (ORF5)
          Length = 272

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 65/236 (27%), Positives = 98/236 (40%), Gaps = 49/236 (20%)

Query: 8   AVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNE-FDFSDFVVFHQLDV 66
           A+VTGA  GIG  I ++LA+ G    L AR+EER  + V+ L+ E FD    V     DV
Sbjct: 20  ALVTGATSGIGLAIARRLAALGARTFLCARDEERLAQTVKELRGEGFDVDGTV----CDV 75

Query: 67  DDPASVASLASFIKTMFGKLDILVNNAGVPGGKLIDGDALLRKVEKCLKTNFYGVERVTE 126
            DPA + +  +     +G +DILVNNAG  GG                          T 
Sbjct: 76  ADPAQIRAYVAAAVQRYGTVDILVNNAGRSGG------------------------GATA 111

Query: 127 ALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLKEFEKDYKE 186
            +   L L    T  N++S   + K + N    +          +K   ++       K+
Sbjct: 112 EIADELWLDVITT--NLTSVFLMTKEVLNAGGMLA---------KKRGRIINIASTGGKQ 160

Query: 187 GSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPH--FHINSVCPGFVKTDMNNNI 240
           G +        A  Y+ SK  +   T+ +  +       +N+VCPGFV+T M   +
Sbjct: 161 GVVH-------AVPYSASKHGVVGLTKALGLELARTGITVNAVCPGFVETPMAERV 209


>RDHC_MOUSE (Q8BYK4) Retinol dehydrogenase 12 (EC 1.1.1.-)
          Length = 316

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 79/282 (28%), Positives = 119/282 (42%), Gaps = 56/282 (19%)

Query: 6   RYAVVTGANKGIGYGICKKLASSGVVVVLTARNEERGLEAVERLKNEFDFSDFVVFHQLD 65
           +  V+TGAN GIG    ++LA  G  V +  R+  +G  A   ++ +   S  V+  +LD
Sbjct: 40  KVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQ-VLVRKLD 98

Query: 66  VDDPASVASLASFIKTMFGKLDILVNNAGV---PGGKLIDGDALLRKVEKCLKTNFYGVE 122
           + D  S+ + A        KL IL+NNAGV   P  K  DG       E     N  G  
Sbjct: 99  LSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDG------FETHFGVNHLGHF 152

Query: 123 RVTEALVPLLQLSTSPTIVNVSSRAGLLKNISNEWARIVFNDIENLTKEKIDEVLKEFEK 182
            +T  L+  L+ S    +VN+SS A L+        +I F+D++              +K
Sbjct: 153 LLTYLLLERLKESAPARVVNLSSIAHLI-------GKIRFHDLQG-------------QK 192

Query: 183 DYKEGSLEIKDWPTFASAYTMSKAALNAYTRIMAKKYPHFHIN--SVCPGFVKTDMNNNI 240
            Y             A AY  SK A   +TR +AK+     +   +V PG V +++  N 
Sbjct: 193 RY-----------CSAFAYGHSKLANLLFTRELAKRLQGTGVTAYAVHPGVVLSEITRNS 241

Query: 241 GNL------------SIDEGVETPLMLALWSNNGP-SGCFFN 269
             L            S  +G +T L  AL  +  P SG +F+
Sbjct: 242 YLLCLLWRLFSPFFKSTSQGAQTSLHCALAEDLEPLSGKYFS 283


>YOXD_BACSU (P14802) Hypothetical oxidoreductase yoxD (EC 1.-.-.-)
          Length = 238

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 14/146 (9%)

Query: 8   AVVTGANKGIGYGICKKLASSGVVVVL---TARNEERGLEAVERLKNEFDFSDFVVFHQL 64
           A++TG  +GIG      LA  GV + L   T+ N E+  E V+ L  +        F   
Sbjct: 9   ALITGGGRGIGRATALALAKEGVNIGLIGRTSANVEKVAEEVKALGVK------AAFAAA 62

Query: 65  DVDDPASVASLASFIKTMFGKLDILVNNAGVP--GGKLIDGDALLRKVEKCLKTNFYGVE 122
           DV D   V    + +K   G +DIL+NNAG+   GG L   D    + E  ++ N  GV 
Sbjct: 63  DVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFL---DLSADEWENIIQVNLMGVY 119

Query: 123 RVTEALVPLLQLSTSPTIVNVSSRAG 148
            VT A++P +    +  I+N+SS AG
Sbjct: 120 HVTRAVLPEMIERKAGDIINISSTAG 145


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.319    0.137    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,369,746
Number of Sequences: 164201
Number of extensions: 1334589
Number of successful extensions: 5243
Number of sequences better than 10.0: 329
Number of HSP's better than 10.0 without gapping: 163
Number of HSP's successfully gapped in prelim test: 166
Number of HSP's that attempted gapping in prelim test: 4670
Number of HSP's gapped (non-prelim): 450
length of query: 276
length of database: 59,974,054
effective HSP length: 109
effective length of query: 167
effective length of database: 42,076,145
effective search space: 7026716215
effective search space used: 7026716215
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)