BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC148755.9 + phase: 0 
         (527 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

HEMZ_ORYSA (O22101) Ferrochelatase II, chloroplast precursor (EC...   773  0.0
HMZ2_ARATH (O04921) Ferrochelatase II, chloroplast precursor (EC...   755  0.0
HEMZ_CUCSA (P42044) Ferrochelatase II, chloroplast precursor (EC...   522  e-148
HEMZ_HORVU (P42045) Ferrochelatase II, chloroplast precursor (EC...   513  e-145
HMZ1_ARATH (P42043) Ferrochelatase I, chloroplast/mitochondrial ...   512  e-144
HEMZ_ANASP (Q8YQR8) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   446  e-125
HEMZ_SYNY3 (P54225) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   433  e-121
HEMZ_SYNEL (Q8DGU6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   427  e-119
HEMZ_SYNPX (Q7U5G0) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   411  e-114
HEMZ_PROMP (Q7V2F5) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   409  e-114
HEMZ_PROMA (Q7VD58) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   407  e-113
HEMZ_PROMM (Q7V6C6) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   403  e-112
HEMZ_GLOVI (Q7NMC7) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   383  e-106
HEMZ_HUMAN (P22830) Ferrochelatase, mitochondrial precursor (EC ...   248  2e-65
HEMZ_XENLA (O57478) Ferrochelatase, mitochondrial precursor (EC ...   247  6e-65
HEMZ_CHICK (O42479) Ferrochelatase, mitochondrial precursor (EC ...   247  6e-65
HEMZ_AQUAE (O67083) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   246  8e-65
HEMZ_BOVIN (P22600) Ferrochelatase, mitochondrial precursor (EC ...   242  2e-63
HEMZ_MOUSE (P22315) Ferrochelatase, mitochondrial precursor (EC ...   234  5e-61
HEMZ_CAUCR (P57777) Ferrochelatase (EC 4.99.1.1) (Protoheme ferr...   224  6e-58

>HEMZ_ORYSA (O22101) Ferrochelatase II, chloroplast precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
           (Fragment)
          Length = 494

 Score =  773 bits (1995), Expect = 0.0
 Identities = 392/455 (86%), Positives = 419/455 (91%), Gaps = 4/455 (0%)

Query: 73  GWSEAQPLVS-KQSLNRHLLPVEALVTSTTQDVSDTPLIGDDKIGVLLLNLGGPETLDDV 131
           GWS +QPL S +  L  H    EA++TS  Q      L+G++KIGVLLLNLGGPETLDDV
Sbjct: 42  GWS-SQPLSSLRHHLRVHSSASEAVLTS--QSDFTKLLVGNEKIGVLLLNLGGPETLDDV 98

Query: 132 QPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEGYASIGGGSPLRRMTDAQA 191
           QPFLFNLFADPDIIRLPRLF FLQKPLAQF+SV+RAPKSKEGYASIGGGSPLR++TDAQA
Sbjct: 99  QPFLFNLFADPDIIRLPRLFRFLQKPLAQFISVVRAPKSKEGYASIGGGSPLRQITDAQA 158

Query: 192 EELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKLVVLPLYPQFSISTSGSSL 251
           E LRK+L +K++PA VYVGMRYWHPFTEEAIE IKRDGITKLVVLPLYPQFSISTSGSSL
Sbjct: 159 EALRKALCDKDIPAKVYVGMRYWHPFTEEAIEQIKRDGITKLVVLPLYPQFSISTSGSSL 218

Query: 252 RLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKELKGFDLPEKVMIFFSAHGV 311
           RLLE IFREDEYLVNMQHTVIPSWYQREGYIKAMA LIEKEL+ F  P+KVMIFFSAHGV
Sbjct: 219 RLLEGIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELRTFSEPQKVMIFFSAHGV 278

Query: 312 PVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQSRVGPVEWLKPYTDETIIE 371
           P+AYVEEAGDPYKAEMEECVDLIMEELEKR ITN+ TLAYQSRVGPVEWL+PYTDETIIE
Sbjct: 279 PLAYVEEAGDPYKAEMEECVDLIMEELEKRGITNSCTLAYQSRVGPVEWLRPYTDETIIE 338

Query: 372 LGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIENWGRVPALGCEPTFISDLA 431
           LG+KGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGI++WGRVPALGCEPTFI+DLA
Sbjct: 339 LGQKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIKHWGRVPALGCEPTFITDLA 398

Query: 432 DAVIESLPYVGAMAVSNLEARQSLVPLGSVEELLAAYDSQRRELPPPILVWEWGWTKSAE 491
           DAVIESLPYVGAMAVSNLEARQ LVPLGSVEELLAAYDS+R ELPPP+ VWEWGWTKSAE
Sbjct: 399 DAVIESLPYVGAMAVSNLEARQPLVPLGSVEELLAAYDSKRDELPPPVTVWEWGWTKSAE 458

Query: 492 TWNGRAAMIAVLLLLFLEVTTGEGFLHQWGILPLF 526
           TWNGRAAM+AVL LL LEVTTGEGFLHQWGILPLF
Sbjct: 459 TWNGRAAMLAVLALLVLEVTTGEGFLHQWGILPLF 493


>HMZ2_ARATH (O04921) Ferrochelatase II, chloroplast precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 512

 Score =  755 bits (1949), Expect = 0.0
 Identities = 382/455 (83%), Positives = 408/455 (88%), Gaps = 12/455 (2%)

Query: 82  SKQSLNRHLLPVEA-LVTSTTQDVSDTPLIGDD-----------KIGVLLLNLGGPETLD 129
           S + L +H LP+ A LVTS   ++S + +I D            KIGVLLLNLGGPETLD
Sbjct: 56  SNRLLGKHSLPLRAALVTSNPLNISSSSVISDAISSSSVITDDAKIGVLLLNLGGPETLD 115

Query: 130 DVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEGYASIGGGSPLRRMTDA 189
           DVQPFLFNLFADPDIIRLP +F FLQKPLAQF+SV RAPKSKEGYASIGGGSPLR +TDA
Sbjct: 116 DVQPFLFNLFADPDIIRLPPVFQFLQKPLAQFISVARAPKSKEGYASIGGGSPLRHITDA 175

Query: 190 QAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKLVVLPLYPQFSISTSGS 249
           QAEELRK L+EKNVPA VYVGMRYWHPFTEEAIE IKRDGITKLVVLPLYPQFSISTSGS
Sbjct: 176 QAEELRKCLWEKNVPAKVYVGMRYWHPFTEEAIEQIKRDGITKLVVLPLYPQFSISTSGS 235

Query: 250 SLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKELKGFDLPEKVMIFFSAH 309
           SLRLLE IFREDEYLVNMQHTVIPSWYQREGYIKAMANLI+ EL  F  P +V+IFFSAH
Sbjct: 236 SLRLLERIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIQSELGKFGSPNQVVIFFSAH 295

Query: 310 GVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQSRVGPVEWLKPYTDETI 369
           GVP+AYVEEAGDPYKAEMEECVDLIMEEL+KRKITNAYTLAYQSRVGPVEWLKPYT+E I
Sbjct: 296 GVPLAYVEEAGDPYKAEMEECVDLIMEELDKRKITNAYTLAYQSRVGPVEWLKPYTEEAI 355

Query: 370 IELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIENWGRVPALGCEPTFISD 429
            ELGKKGV++LLAVPISFVSEHIETLEEIDVEYKELAL+SGI+NWGRVPALG EP FISD
Sbjct: 356 TELGKKGVENLLAVPISFVSEHIETLEEIDVEYKELALKSGIKNWGRVPALGTEPMFISD 415

Query: 430 LADAVIESLPYVGAMAVSNLEARQSLVPLGSVEELLAAYDSQRRELPPPILVWEWGWTKS 489
           LADAV+ESLPYVGAMAVSNLEARQSLVPLGSVEELLA YDSQRRELP P+ +WEWGWTKS
Sbjct: 416 LADAVVESLPYVGAMAVSNLEARQSLVPLGSVEELLATYDSQRRELPAPVTMWEWGWTKS 475

Query: 490 AETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGILP 524
           AETWNGRAAM+AVL LL LEVTTG+GFLHQWGILP
Sbjct: 476 AETWNGRAAMLAVLALLVLEVTTGKGFLHQWGILP 510


>HEMZ_CUCSA (P42044) Ferrochelatase II, chloroplast precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 514

 Score =  522 bits (1345), Expect = e-148
 Identities = 251/334 (75%), Positives = 298/334 (89%)

Query: 112 DDKIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSK 171
           DDK+GVLLLNLGGPETLDDVQPFL+NLFADPDIIRLPRLF FLQ+PLA+ +S  RAPKSK
Sbjct: 112 DDKVGVLLLNLGGPETLDDVQPFLYNLFADPDIIRLPRLFRFLQEPLAKLISTYRAPKSK 171

Query: 172 EGYASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGIT 231
           EGYASIGGGSPLR++TD QA+ L+ +L EKN+  NVYVGMRYW+PFTEEAI+ IKRDGIT
Sbjct: 172 EGYASIGGGSPLRKITDEQAQALKMALAEKNMSTNVYVGMRYWYPFTEEAIQQIKRDGIT 231

Query: 232 KLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEK 291
           +LVVLPLYPQ+SIST+GSS+R+L+ +FRED YL ++  ++I SWYQREGYIK+MA+L++ 
Sbjct: 232 RLVVLPLYPQYSISTTGSSIRVLQKMFREDAYLSSLPVSIIKSWYQREGYIKSMADLMQA 291

Query: 292 ELKGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAY 351
           ELK F  P++VMIFFSAHGVPV+YVE AGDPYK +MEEC+ LIM+EL+ R I N +TLAY
Sbjct: 292 ELKNFANPQEVMIFFSAHGVPVSYVENAGDPYKDQMEECICLIMQELKARGIGNEHTLAY 351

Query: 352 QSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGI 411
           QSRVGPV+WLKPYTDE ++ELG+KG+KSLLAVP+SFVSEHIETLEEID+EYK LALESGI
Sbjct: 352 QSRVGPVQWLKPYTDEVLVELGQKGIKSLLAVPVSFVSEHIETLEEIDMEYKHLALESGI 411

Query: 412 ENWGRVPALGCEPTFISDLADAVIESLPYVGAMA 445
           +NWGRVPAL C  +FISDLADAVIE+LP   A+A
Sbjct: 412 QNWGRVPALNCNSSFISDLADAVIEALPSATALA 445


>HEMZ_HORVU (P42045) Ferrochelatase II, chloroplast precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 484

 Score =  513 bits (1321), Expect = e-145
 Identities = 265/422 (62%), Positives = 326/422 (76%), Gaps = 18/422 (4%)

Query: 47  RCS---GGHTEASSNVN----PLKTCIVGKF--SPGWSEAQPLVSKQSLNRHLLPVEA-- 95
           RCS    G T+   N++    PL     GK   + G     P++  Q    H L V +  
Sbjct: 31  RCSTNLAGSTKCEQNLHGKAKPLLLSASGKARGTSGLVHRSPVLKHQ----HHLSVRSTS 86

Query: 96  --LVTSTTQDVSDTPLIG-DDKIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFS 152
             + T+  +DV        ++K+GVLLLNLGGPETL+DVQPFLFNLFADPDIIRLPRLF 
Sbjct: 87  TDVCTTFDEDVKGVSSHAVEEKVGVLLLNLGGPETLNDVQPFLFNLFADPDIIRLPRLFR 146

Query: 153 FLQKPLAQFVSVLRAPKSKEGYASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMR 212
           FLQ+PLA+ +S  RAPKS EGYASIGGGSPLR++TD QA  L+ +L  KN+ A++YVGMR
Sbjct: 147 FLQRPLAKLISTFRAPKSNEGYASIGGGSPLRKITDEQANALKVALKSKNLEADIYVGMR 206

Query: 213 YWHPFTEEAIELIKRDGITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVI 272
           YW+PFTEEAI+ IK+D ITKLVVLPLYPQ+SISTSGSS+R+L++I +ED Y   +  ++I
Sbjct: 207 YWYPFTEEAIDQIKKDKITKLVVLPLYPQYSISTSGSSIRVLQNIVKEDPYFAGLPISII 266

Query: 273 PSWYQREGYIKAMANLIEKELKGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVD 332
            SWYQREGY+K+MA+LIEKEL  F  PE+VMIFFSAHGVP+ YV++AGDPY+ +ME+C+ 
Sbjct: 267 ESWYQREGYVKSMADLIEKELSVFSNPEEVMIFFSAHGVPLTYVKDAGDPYRDQMEDCIA 326

Query: 333 LIMEELEKRKITNAYTLAYQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHI 392
           LIMEEL+ R   N +TLAYQSRVGPV+WLKPYTDE ++ELG+KGVKSLLAVP+SFVSEHI
Sbjct: 327 LIMEELKSRGTLNDHTLAYQSRVGPVQWLKPYTDEVLVELGQKGVKSLLAVPVSFVSEHI 386

Query: 393 ETLEEIDVEYKELALESGIENWGRVPALGCEPTFISDLADAVIESLPYVGAMAVSNLEAR 452
           ETLEEID+EY+ELALESGIENWGRVPALGC  +FISDLADAV+E+LP   AMA   ++  
Sbjct: 387 ETLEEIDMEYRELALESGIENWGRVPALGCTSSFISDLADAVVEALPSASAMATRKVKDT 446

Query: 453 QS 454
            S
Sbjct: 447 DS 448


>HMZ1_ARATH (P42043) Ferrochelatase I, chloroplast/mitochondrial
           precursor (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme
           synthetase)
          Length = 466

 Score =  512 bits (1318), Expect = e-144
 Identities = 244/340 (71%), Positives = 298/340 (86%)

Query: 109 LIGDDKIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAP 168
           ++ +DKIGVLLLNLGGPETL+DVQPFL+NLFADPDIIRLPR F FLQ  +A+F+SV+RAP
Sbjct: 84  VVAEDKIGVLLLNLGGPETLNDVQPFLYNLFADPDIIRLPRPFQFLQGTIAKFISVVRAP 143

Query: 169 KSKEGYASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRD 228
           KSKEGYA+IGGGSPLR++TD QA+ ++ SL  KN+ ANVYVGMRYW+PFTEEA++ IK+D
Sbjct: 144 KSKEGYAAIGGGSPLRKITDEQADAIKMSLQAKNIAANVYVGMRYWYPFTEEAVQQIKKD 203

Query: 229 GITKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANL 288
            IT+LVVLPLYPQ+SIST+GSS+R+L+ +FR+D YL  +   +I SWYQR GY+ +MA+L
Sbjct: 204 KITRLVVLPLYPQYSISTTGSSIRVLQDLFRKDPYLAGVPVAIIKSWYQRRGYVNSMADL 263

Query: 289 IEKELKGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYT 348
           IEKEL+ F  P++VMIFFSAHGVPV+YVE AGDPY+ +MEEC+DLIMEEL+ R + N + 
Sbjct: 264 IEKELQTFSDPKEVMIFFSAHGVPVSYVENAGDPYQKQMEECIDLIMEELKARGVLNDHK 323

Query: 349 LAYQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALE 408
           LAYQSRVGPV+WLKPYTDE +++LGK GVKSLLAVP+SFVSEHIETLEEID+EY+ELALE
Sbjct: 324 LAYQSRVGPVQWLKPYTDEVLVDLGKSGVKSLLAVPVSFVSEHIETLEEIDMEYRELALE 383

Query: 409 SGIENWGRVPALGCEPTFISDLADAVIESLPYVGAMAVSN 448
           SG+ENWGRVPALG  P+FI+DLADAVIESLP   AM+  N
Sbjct: 384 SGVENWGRVPALGLTPSFITDLADAVIESLPSAEAMSNPN 423


>HEMZ_ANASP (Q8YQR8) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 388

 Score =  446 bits (1148), Expect = e-125
 Identities = 228/410 (55%), Positives = 296/410 (71%), Gaps = 25/410 (6%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           ++GVLLLNLGGP+ L+DV PFLFNLF+DP+IIRLP  F +LQKPLA F++  R   S+E 
Sbjct: 3   RVGVLLLNLGGPDKLEDVAPFLFNLFSDPEIIRLP--FRWLQKPLAWFIASRRTKTSQEN 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           Y  IGGGSPLRR+T+AQ E L++ L      AN+YVGMRYWHP+TEEAI L+ +D +  L
Sbjct: 61  YKQIGGGSPLRRITEAQGEALKEQLHYLGQEANIYVGMRYWHPYTEEAIALLTQDNLDNL 120

Query: 234 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKEL 293
           V+LPLYPQFSISTSGSS RLLE +++ED  L  +++TVIPSWY+  GY++AMA LI +E+
Sbjct: 121 VILPLYPQFSISTSGSSFRLLERLWQEDPKLQRLEYTVIPSWYKEPGYLQAMAELIRQEI 180

Query: 294 KGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQS 353
           + F  P++V +FFSAHGVP +YVEEAGDPY+ E+EEC  LIM+ L +    N +TLAYQS
Sbjct: 181 EQFPHPDQVHVFFSAHGVPKSYVEEAGDPYQQEIEECTALIMQTLNR---PNPHTLAYQS 237

Query: 354 RVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIEN 413
           RVGPVEWL+PYT++ + ELG +GVK L+ VPISFVSEHIETL+EID+EY+E+A E+GI N
Sbjct: 238 RVGPVEWLQPYTEDALKELGAQGVKDLVVVPISFVSEHIETLQEIDIEYREIAEEAGIHN 297

Query: 414 WGRVPALGCEPTFISDLADAVIESLPYVGAMAVSNLEARQSLVPLGSVEELLAAYDSQRR 473
           + RVPA    P FI  LAD VI++L           +    L     +++++  Y     
Sbjct: 298 FRRVPAPNTHPVFIRALADLVIDALN----------KPSFKLSQAAQIKKMVKMY----- 342

Query: 474 ELPPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
             PP    WEWG T SAE WNGR AM+  + L+ +E+ TG+G LH  G+L
Sbjct: 343 --PPE--SWEWGMTSSAEVWNGRIAMLGFIALI-IELVTGQGLLHMIGLL 387


>HEMZ_SYNY3 (P54225) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 387

 Score =  433 bits (1114), Expect = e-121
 Identities = 228/410 (55%), Positives = 291/410 (70%), Gaps = 25/410 (6%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           ++GVLLLNLGGPE L+DV+PFLFNLFADP+IIRLP  F +LQKPLA  +S LRA KS+  
Sbjct: 3   RVGVLLLNLGGPEKLEDVRPFLFNLFADPEIIRLP--FPWLQKPLAWLISTLRAKKSQAN 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           YA IGGGSPL ++T+AQA  L   L      A VY+GMRYWHPFTEEA+E IK D + +L
Sbjct: 61  YAEIGGGSPLLQITEAQASALTTRLERLGQDAKVYIGMRYWHPFTEEAVEKIKGDRLQRL 120

Query: 234 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKEL 293
           V+LPLYP FSISTSGSS R+LE ++  D  L  + +++IPSWY   GY++AMA+LI +EL
Sbjct: 121 VILPLYPHFSISTSGSSFRVLEEMWHNDPSLRQLDYSLIPSWYDHPGYLQAMADLIAQEL 180

Query: 294 KGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQS 353
           K F  P++  IFFSAHGVP +YV+EAGDPY+AE+E C  LIM  L++    N YTLAYQS
Sbjct: 181 KKFPNPDQAHIFFSAHGVPQSYVDEAGDPYQAEIEACTRLIMRTLDR---PNQYTLAYQS 237

Query: 354 RVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIEN 413
           RVGPVEWLKPYT+E + +LG +G+  LL VPISFVSEHIETL+EID+EY+E+A E+GI+N
Sbjct: 238 RVGPVEWLKPYTEEALQKLGAEGIDDLLVVPISFVSEHIETLQEIDIEYREIAEEAGIDN 297

Query: 414 WGRVPALGCEPTFISDLADAVIESLPYVGAMAVSNLEARQSLVPLGSVEELLAAYDSQRR 473
           + RVPAL   P FI  LA  V++SL        ++       VP    ++ +  Y  +R 
Sbjct: 298 FQRVPALNTHPVFIDALAQMVMDSL--------NDPPCTFETVP--HPKKNMKMYPQER- 346

Query: 474 ELPPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
                   WEWG T +AE WNGR AM+  + LL +E+ +G+G LH  G+L
Sbjct: 347 --------WEWGLTTAAEVWNGRLAMLGFIALL-VELISGQGPLHFVGLL 387


>HEMZ_SYNEL (Q8DGU6) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 388

 Score =  427 bits (1098), Expect = e-119
 Identities = 228/408 (55%), Positives = 291/408 (70%), Gaps = 25/408 (6%)

Query: 116 GVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEGYA 175
           GVLLLNLGGP+  +DV+PFL+NLF+DP+IIRLP  F +LQKPLA F+S  RA +S+  YA
Sbjct: 6   GVLLLNLGGPDRPEDVRPFLYNLFSDPEIIRLP--FRWLQKPLAWFISTSRARRSQANYA 63

Query: 176 SIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKLVV 235
            IGGGSPLRR+T+ QA  L+ +L    + AN+Y+GMRYWHPFTEEAI  IK D I +LV+
Sbjct: 64  QIGGGSPLRRITEQQARALKDALEGIGIEANLYIGMRYWHPFTEEAIAQIKADQIRELVI 123

Query: 236 LPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKELKG 295
           LPLYPQFSISTSGSS RLLES++ +D  L  +++T+IPSWY   GY+ AMA+LI +EL  
Sbjct: 124 LPLYPQFSISTSGSSFRLLESLWNQDPELQKIRYTLIPSWYNHPGYVAAMADLIRQELDR 183

Query: 296 FDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQSRV 355
              P++ +IFFSAHGVP +YV EAGDPY+ E+E CV LIM  L +    NA+ LAYQSRV
Sbjct: 184 CPNPDEAVIFFSAHGVPKSYVTEAGDPYQEEIEACVRLIMAALNR---PNAHVLAYQSRV 240

Query: 356 GPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIENWG 415
           GPVEWL+PYT++ I+EL  +GVK+L+ VPISFVSEHIETL+EID+EY+E+A E+GIE + 
Sbjct: 241 GPVEWLQPYTEDVILELAAQGVKTLVVVPISFVSEHIETLQEIDIEYREIAAEAGIEVFR 300

Query: 416 RVPALGCEPTFISDLADAVIESLPYVGAMAVSNLEARQSLVPLGSVEELLAAYDSQRREL 475
           RVPAL     FIS LA  V E+L    A   +  E  QS        + +  Y  +R   
Sbjct: 301 RVPALNDHNGFISALAQLVKEAL---AAPPRTFAEVNQS-------RKRVKLYPQER--- 347

Query: 476 PPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
                 WEWG T +AE WNGR AM+  L L+ +E+ +G+G LH  G+L
Sbjct: 348 ------WEWGMTSAAERWNGRLAMLGFLALM-IELISGQGPLHMLGLL 388


>HEMZ_SYNPX (Q7U5G0) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 391

 Score =  411 bits (1057), Expect = e-114
 Identities = 221/413 (53%), Positives = 274/413 (65%), Gaps = 27/413 (6%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           ++GV+LLNLGGPE + DV PFL+NLFADP+IIRLP     LQKPLA  +S LR+ KS+E 
Sbjct: 3   RVGVVLLNLGGPERIQDVGPFLYNLFADPEIIRLPS--PALQKPLAWLISTLRSGKSQEA 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           Y SIGGGSPLRR+T+ QA EL+  L ++ + A  YV MRYWHPFTE A+  +K DG+ ++
Sbjct: 61  YRSIGGGSPLRRITEQQARELQSLLRQRGLDATTYVAMRYWHPFTESAVADMKADGMDEV 120

Query: 234 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKEL 293
           VVLPLYP FSISTSGSS R L+ + + D     +    I SW+   GYIKAMA LI +E+
Sbjct: 121 VVLPLYPHFSISTSGSSFRELQRLRQGDAAFEQLPIRCIRSWFDHPGYIKAMAELIAEEV 180

Query: 294 KGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEEL-EKRKITNAYTLAYQ 352
           +  D PEK  +FFSAHGVP +YVEEAGDPY+ ++E C DLIM+ L E    +N +TLAYQ
Sbjct: 181 RNSDDPEKAHVFFSAHGVPKSYVEEAGDPYQQQIEACTDLIMKSLAEHMGHSNPHTLAYQ 240

Query: 353 SRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIE 412
           SRVGPVEWLKPYT+E + +LG+     L+ VPISFVSEHIETLEEID+EY+ELA E+G+ 
Sbjct: 241 SRVGPVEWLKPYTEEALEQLGEAKTNDLVVVPISFVSEHIETLEEIDIEYRELATEAGVV 300

Query: 413 NWGRVPALGCEPTFISDLADAVIESL--PYVGAMAVSNLEARQSLVPLGSVEELLAAYDS 470
           N+ RV AL   P FI  LAD V  SL  P V   A + L  +  L P             
Sbjct: 301 NFRRVRALDTYPPFIEGLADLVTTSLEGPEVSLDAAAELPTKVKLYPQEK---------- 350

Query: 471 QRRELPPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
                      WEWGW  S+E WNGR AM+     L LE+ +G G LH  G+L
Sbjct: 351 -----------WEWGWNNSSEVWNGRLAMLGFSAFL-LELISGHGPLHALGLL 391


>HEMZ_PROMP (Q7V2F5) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 391

 Score =  409 bits (1052), Expect = e-114
 Identities = 211/414 (50%), Positives = 276/414 (65%), Gaps = 27/414 (6%)

Query: 113 DKIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKE 172
           +K+GVLL+NLGGPE + DV PFL+NLF+DP+IIRLP      QKPLA  +S LR+  S++
Sbjct: 2   EKVGVLLMNLGGPERITDVGPFLYNLFSDPEIIRLP--VPAFQKPLAWLISTLRSTTSQQ 59

Query: 173 GYASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITK 232
            Y SIGGGSP+RR+T+ QA EL+  L +K +    Y+ MRYWHPFTE AI  +K DG+ +
Sbjct: 60  AYLSIGGGSPIRRITEQQARELQSKLRDKGLNVTTYIAMRYWHPFTESAIADMKADGVDQ 119

Query: 233 LVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKE 292
           +VVLPLYP FSISTSGSS R L+ +   D     +    + SW+ + GY+K+M  LI ++
Sbjct: 120 IVVLPLYPHFSISTSGSSFRELKKLRDSDSEFQKIPMRCVRSWFSQSGYLKSMVELISEQ 179

Query: 293 LKGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEK-RKITNAYTLAY 351
           +   + P+   IFF+AHGVP +YVEEAGDPYK ++E+C  LI++ELEK    TN YTL+Y
Sbjct: 180 ISLCESPDSAHIFFTAHGVPKSYVEEAGDPYKEQIEDCSLLIIDELEKYLGHTNPYTLSY 239

Query: 352 QSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGI 411
           QSRVGPVEWLKPYT+E + +LGK  V  L+ VPISFV EHIETL+EID+EYKE+A ++GI
Sbjct: 240 QSRVGPVEWLKPYTEEVLTDLGKAKVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGI 299

Query: 412 ENWGRVPALGCEPTFISDLADAVIESL--PYVGAMAVSNLEARQSLVPLGSVEELLAAYD 469
            N+ RV AL   PTFI  L++ V+  L  P +     S L  +  L P            
Sbjct: 300 VNFRRVKALNTHPTFIDGLSELVVSCLEGPIINIEKASELPEKVKLYPQEK--------- 350

Query: 470 SQRRELPPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
                       W+WGW  S+E WNGR AMI V L+LF+E+ +G G LH+ GIL
Sbjct: 351 ------------WQWGWNNSSEVWNGRVAMI-VFLILFIELISGSGPLHKLGIL 391


>HEMZ_PROMA (Q7VD58) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 391

 Score =  407 bits (1045), Expect = e-113
 Identities = 215/411 (52%), Positives = 276/411 (66%), Gaps = 23/411 (5%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           ++GVLL+NLGGPE + DV PFL+NLF+DP+IIRLP      QKPLA F+S LR+ KS++ 
Sbjct: 3   RVGVLLMNLGGPERIKDVGPFLYNLFSDPEIIRLP--LPIFQKPLAWFISTLRSSKSQKA 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           Y +IGGGSPLRR+T+ QA EL+ +L  + + A  YV MRYWHPFTE A+E IK D I ++
Sbjct: 61  YQAIGGGSPLRRITEQQARELQSALRNRGINATSYVAMRYWHPFTESAVEDIKADNINEV 120

Query: 234 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKEL 293
           VVLPLYP FSISTSGSS R L  +   D+    +    I SW+   GYI +MA LIE+E+
Sbjct: 121 VVLPLYPHFSISTSGSSFRELRRLREVDKEFQKLSIRCIRSWFDNTGYIASMAELIEQEI 180

Query: 294 KGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKR-KITNAYTLAYQ 352
              + P    I F+AHGVP +YVEEAGDPYK E+++C  LI++++EK    +N+YTL+YQ
Sbjct: 181 SSCESPNAAHICFTAHGVPKSYVEEAGDPYKDEIQDCALLIIDKVEKSLGFSNSYTLSYQ 240

Query: 353 SRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIE 412
           SRVGP EWLKPYT+E + ELG  GVK L+ VPISFVSEHIETL+EID+EYK++AL +GI 
Sbjct: 241 SRVGPEEWLKPYTEEVLEELGANGVKELIVVPISFVSEHIETLQEIDIEYKKIALNNGII 300

Query: 413 NWGRVPALGCEPTFISDLADAVIESLPYVGAMAVSNLEARQSLVPLGSVEELLAAYDSQR 472
           N+ RV AL   P FI+ LAD V        A  +S  E   SL     + E +  Y  ++
Sbjct: 301 NFRRVKALDTYPLFINGLADLV--------ASCLSGPEI--SLDEAAKLPEKVKLYPQEK 350

Query: 473 RELPPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
                    W+WGW  SAE WNGR AM  V ++ F E+  G G LH  G+L
Sbjct: 351 ---------WQWGWNNSAEVWNGRVAMF-VFIICFFELVIGNGPLHYIGLL 391


>HEMZ_PROMM (Q7V6C6) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 391

 Score =  403 bits (1035), Expect = e-112
 Identities = 215/413 (52%), Positives = 275/413 (66%), Gaps = 27/413 (6%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           ++GVLL+NLGGPE + DV PFLFN+FADP+IIRLP     LQ+PLA  +S LR+ KS++ 
Sbjct: 3   RVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPN--PALQRPLAWLISTLRSSKSEQA 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           Y SIGGGSPLRR+T+ QA EL+  L ++ + A  YV MRYWHPFTE A+  IK DGI ++
Sbjct: 61  YRSIGGGSPLRRITEQQARELQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQV 120

Query: 234 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKEL 293
           VVLPLYP FSISTSGSS R L+ + + DE    +    I SWY   GY++AMA LI +++
Sbjct: 121 VVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRSWYDHPGYVRAMAELIAEQV 180

Query: 294 KGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEK-RKITNAYTLAYQ 352
           +  D+PE+  +FFSAHGVP +YVE+AGDPY+ E+E C  LIM ELE      N ++LAYQ
Sbjct: 181 RLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ 240

Query: 353 SRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIE 412
           SRVGP EW++PYTD+ I +LG+ G + L+ VPISFVSEHIETL E+D+EY+ELA E+GI 
Sbjct: 241 SRVGPEEWIQPYTDQVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIV 300

Query: 413 NWGRVPALGCEPTFISDLADAVIESL--PYVGAMAVSNLEARQSLVPLGSVEELLAAYDS 470
           ++ RVPAL   PTFI  LAD V  SL  P +     + L  R    P             
Sbjct: 301 HFRRVPALDTYPTFIEGLADLVGSSLEGPEINLDEAAKLAGRVKFYP------------- 347

Query: 471 QRRELPPPILVWEWGWTKSAETWNGRAAMIAVLLLLFLEVTTGEGFLHQWGIL 523
           Q R        W+WG   S+E WNGR AM+     L LE+ +G G LH  G+L
Sbjct: 348 QER--------WQWGLNTSSEAWNGRIAMLGFAAFL-LELISGHGPLHAIGLL 391


>HEMZ_GLOVI (Q7NMC7) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 327

 Score =  383 bits (983), Expect = e-106
 Identities = 191/325 (58%), Positives = 247/325 (75%), Gaps = 5/325 (1%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           ++GVLLLNLGGP+  +DV+PFL+NLFADP+IIR+P     LQKPLA  +S LRAPKS++ 
Sbjct: 3   EVGVLLLNLGGPDKQEDVRPFLYNLFADPEIIRIP--VPPLQKPLAWLISTLRAPKSRKN 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           Y +IGGGSPLR +T+ Q   L+K+L  + +   VYVGMRYWHPFTEEA+  IK DGI +L
Sbjct: 61  YQAIGGGSPLRAITNQQGRVLKKALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRL 120

Query: 234 VVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKEL 293
           V+LPLYPQ+SISTSGSS +LL+ I+  D  L  ++   I SWY R GYI+AM   + + L
Sbjct: 121 VLLPLYPQYSISTSGSSFKLLDQIWARDPSLKAIERITINSWYSRPGYIRAMGERVREGL 180

Query: 294 KGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQS 353
             FD P+ V I FSAHGVP  YV++ GDPY+ + EE VDL+M+ L +    NA++LAYQS
Sbjct: 181 DKFDNPDGVHILFSAHGVPRTYVDQDGDPYQRQTEETVDLVMQSLGR---PNAHSLAYQS 237

Query: 354 RVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIEN 413
           RVGPVEWLKPYT++TI EL +KGV+SLLAVP+SF+SEHIETL+EI++EY+E+A  +GI +
Sbjct: 238 RVGPVEWLKPYTEDTINELAQKGVRSLLAVPVSFISEHIETLQEIEIEYREVAEAAGIHD 297

Query: 414 WGRVPALGCEPTFISDLADAVIESL 438
           + R  AL    TFI DLA+ VIE+L
Sbjct: 298 FRRAKALNVNKTFIDDLAEMVIENL 322


>HEMZ_HUMAN (P22830) Ferrochelatase, mitochondrial precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 423

 Score =  248 bits (634), Expect = 2e-65
 Identities = 151/370 (40%), Positives = 203/370 (54%), Gaps = 15/370 (4%)

Query: 71  SPGWSEAQPLVSKQSLNRHLLPVEALVTSTTQDVSDTPLIGDDKIGVLLLNLGGPETLDD 130
           S  W   QP   K       +  E    +        P     K G+L+LN+GGPETL D
Sbjct: 25  SSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGD 84

Query: 131 VQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEGYASIGGGSPLRRMTDAQ 190
           V  FL  LF D D++ LP     +Q  LA F++  R PK +E Y  IGGGSP++  T  Q
Sbjct: 85  VHDFLLRLFLDQDLMTLP-----IQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQ 139

Query: 191 AEELRKSLFE---KNVPANVYVGMRYWHPFTEEAIELIKRDGITKLVVLPLYPQFSISTS 247
            E + K L E      P   Y+G RY HP TEEAIE ++RDG+ + +    YPQ+S ST+
Sbjct: 140 GEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTT 199

Query: 248 GSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEKELKGFDLPEK--VMIF 305
           GSSL  +   + +      M+ + I  W      I+  A+ I KEL  F L ++  V+I 
Sbjct: 200 GSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVIL 259

Query: 306 FSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAYQSRVGPVEWLKPYT 365
           FSAH +P++ V   GDPY  E+   V  +ME LE     N Y L +QS+VGP+ WL P T
Sbjct: 260 FSAHSLPMSVVNR-GDPYPQEVSATVQKVMERLE---YCNPYRLVWQSKVGPMPWLGPQT 315

Query: 366 DETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKE-LALESGIENWGRVPALGCEP 424
           DE+I  L ++G K++L VPI+F S+HIETL E+D+EY + LA E G+EN  R  +L   P
Sbjct: 316 DESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNP 375

Query: 425 TFISDLADAV 434
            F   LAD V
Sbjct: 376 LFSKALADLV 385


>HEMZ_XENLA (O57478) Ferrochelatase, mitochondrial precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 411

 Score =  247 bits (630), Expect = 6e-65
 Identities = 143/331 (43%), Positives = 198/331 (59%), Gaps = 15/331 (4%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           K G+L+LN+GGPETLDDV  FL  LF D D++ LP      Q  LA F++  R PK +E 
Sbjct: 55  KTGILMLNMGGPETLDDVHGFLLRLFLDKDLMTLPA-----QSKLAPFIAKRRTPKIQEQ 109

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKN---VPANVYVGMRYWHPFTEEAIELIKRDGI 230
           Y+ IGGGSP+++ T+ Q E + K L E +    P   Y+G RY  P TE AIE ++RDG+
Sbjct: 110 YSKIGGGSPIKKWTEQQGEGMVKLLDELSPATAPHKYYIGFRYVRPLTEAAIEEMERDGV 169

Query: 231 TKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIE 290
            + +    YPQ+S ST+GSSL  +   +        M+ +VI  W      I+  A+ I+
Sbjct: 170 ERAIAFTQYPQYSCSTTGSSLNAIYRYYNAKGTQPKMKWSVIDRWPTHPLLIQCFADHIQ 229

Query: 291 KELKGF--DLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYT 348
           KEL  F  D   +V+I FSAH +P++ V   GDPY  E+   V  +ME L     +N Y 
Sbjct: 230 KELNMFPADKRGEVVILFSAHSLPMSVVNR-GDPYPQEVGATVQKVMERLG---FSNPYR 285

Query: 349 LAYQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKE-LAL 407
           L +QS+VGP+ WL P TDE+I  L ++G K++L VPI+F S+HIETL E+D+EY + LA 
Sbjct: 286 LVWQSKVGPMAWLGPQTDESIKGLCQRGKKNILLVPIAFTSDHIETLYELDIEYAQVLAK 345

Query: 408 ESGIENWGRVPALGCEPTFISDLADAVIESL 438
           E G+EN  R  +L   P F   LAD V+  +
Sbjct: 346 ECGVENIRRSESLNGNPLFSKALADLVLSHM 376


>HEMZ_CHICK (O42479) Ferrochelatase, mitochondrial precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 402

 Score =  247 bits (630), Expect = 6e-65
 Identities = 142/327 (43%), Positives = 197/327 (59%), Gaps = 15/327 (4%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           K G+L+LN+GGPE LDDV  FL  LF D D++ LP      Q  LA F++  R P+ +E 
Sbjct: 47  KTGILMLNMGGPERLDDVHDFLLRLFLDRDLMTLPA-----QNKLAPFIAKRRTPRIQEQ 101

Query: 174 YASIGGGSPLRRMTDAQAEELRK---SLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGI 230
           Y+ IGGGSP+++ T  Q E + K   S+  +  P   Y+G RY HP TEEAIE ++ DGI
Sbjct: 102 YSRIGGGSPIKKWTAVQGEGMVKLLDSMSPQTAPHKYYIGFRYVHPLTEEAIEEMEDDGI 161

Query: 231 TKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIE 290
            + +    YPQ+S ST+GSSL  +   + +      M+ ++I  W      I+  A+ I+
Sbjct: 162 ERAIAFTQYPQYSCSTTGSSLNAIYRYYNKKGKKPKMKWSIIDRWPTHPLLIQCFADHIQ 221

Query: 291 KELKGF--DLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYT 348
           KEL  F  D  + V+I FSAH +P++ V   GDPY  E+   V  +ME+L     +N Y 
Sbjct: 222 KELDLFPPDKRKDVVILFSAHSLPMSVVNR-GDPYPQEVGATVQRVMEKLNH---SNPYR 277

Query: 349 LAYQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKE-LAL 407
           L +QS+VGP+ WL P TDETI  L ++G K++L VPI+F S+HIETL E+D+EY + LA 
Sbjct: 278 LVWQSKVGPMPWLVPQTDETIKGLCQRGKKNMLLVPIAFTSDHIETLYELDIEYAQVLAN 337

Query: 408 ESGIENWGRVPALGCEPTFISDLADAV 434
           E G+EN  R  +L   P F   LAD V
Sbjct: 338 ECGVENIRRAESLNGNPLFSKALADLV 364


>HEMZ_AQUAE (O67083) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 309

 Score =  246 bits (629), Expect = 8e-65
 Identities = 147/324 (45%), Positives = 201/324 (61%), Gaps = 23/324 (7%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           K GV+L+NLGGP++L+ V+PFL+NLF+DPDI  LP      QK LA+ ++ LRA K++  
Sbjct: 2   KKGVILINLGGPDSLEAVEPFLYNLFSDPDIFSLP-----FQKVLAKIIAKLRAKKTRHY 56

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKNVPANVYVGMRYWHPFTEEAIELIKRDGITKL 233
           Y  +GG SP    T  QA+ L++ L E      V VGMRYW P+ ++A+  + ++GI ++
Sbjct: 57  YELMGGKSPQYEQTLEQAKALQERLGEDY---KVVVGMRYWKPYIKDALSELLKEGINEV 113

Query: 234 VVLPLYPQFSISTSGSSLRLLE---SIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIE 290
           ++LPLYPQ+S +T+GS+    E      + D   V      I  +Y    YIKA A  I+
Sbjct: 114 ILLPLYPQYSKTTTGSAFNEFERSKKALKADHIKVKK----IEHFYDHPLYIKAWAEQIK 169

Query: 291 KELKGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLA 350
           + +   + PE+    FSAH +P   +EE GDPY+ + E+ V LIME   + +    YTLA
Sbjct: 170 QSV---EKPEEYHFLFSAHSLPKKLIEE-GDPYQEQTEKTVKLIMENFPEVE----YTLA 221

Query: 351 YQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESG 410
           YQS+VG  +WL+P TDE I  L KK VK LL +PISFVSEH ETL E+D +Y+ELA E G
Sbjct: 222 YQSKVGFGKWLEPSTDEVIRNLIKKEVKKLLVIPISFVSEHSETLYELDKQYRELAQELG 281

Query: 411 IENWGRVPALGCEPTFISDLADAV 434
            E + RVP L   P FIS L D V
Sbjct: 282 YEEFVRVPTLRTNPYFISALEDLV 305


>HEMZ_BOVIN (P22600) Ferrochelatase, mitochondrial precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 416

 Score =  242 bits (617), Expect = 2e-63
 Identities = 144/328 (43%), Positives = 196/328 (58%), Gaps = 17/328 (5%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           + G+L+LN+GGPET+++VQ FL  LF D D++ LP     +Q  L  F++  R PK +E 
Sbjct: 61  RTGILMLNMGGPETVEEVQDFLQRLFLDQDLMTLP-----VQDKLGPFIAKRRTPKIQEQ 115

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKN---VPANVYVGMRYWHPFTEEAIELIKRDGI 230
           Y  IGGGSP++  T  Q E + K L E +    P   Y+G RY HP TEEAIE ++RDG+
Sbjct: 116 YRRIGGGSPIKMWTSKQGEGMVKLLDELSPHTAPHKYYIGFRYVHPLTEEAIEEMERDGL 175

Query: 231 TKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIE 290
            + V    YPQ+S ST+GSSL  +   + E      M+ + I  W      I+  A+ I 
Sbjct: 176 ERAVAFTQYPQYSCSTTGSSLNAIYRYYNEVGRKPTMKWSTIDRWPTHPLLIQCFADHIL 235

Query: 291 KELKGFDLPEK---VMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAY 347
           KEL  F  PEK   V+I FSAH +P++ V   GDPY  E+   V  +M++L     +N Y
Sbjct: 236 KELDHFP-PEKRREVVILFSAHSLPMSVVNR-GDPYPQEVGATVQRVMDKLG---YSNPY 290

Query: 348 TLAYQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKE-LA 406
            L +QS+VGP+ WL P TDE I  L K+G K++L VPI+F S+HIETL E+D+EY + LA
Sbjct: 291 RLVWQSKVGPMPWLGPQTDEAIKGLCKRGRKNILLVPIAFTSDHIETLYELDIEYSQVLA 350

Query: 407 LESGIENWGRVPALGCEPTFISDLADAV 434
            E G+EN  R  +L   P F   LAD V
Sbjct: 351 SECGLENIRRAESLNGNPLFSKALADLV 378


>HEMZ_MOUSE (P22315) Ferrochelatase, mitochondrial precursor (EC
           4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase)
          Length = 420

 Score =  234 bits (596), Expect = 5e-61
 Identities = 142/327 (43%), Positives = 192/327 (58%), Gaps = 17/327 (5%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           K G+L+LN+GGPETL +VQ FL  LF D D++ LP     +Q  LA F++  R PK +E 
Sbjct: 67  KTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLP-----IQNKLAPFIAKRRTPKIQE- 120

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLFEKN---VPANVYVGMRYWHPFTEEAIELIKRDGI 230
              IGGGSP++  T  Q E + K L E +    P   Y+G RY HP TEEAIE ++RDG+
Sbjct: 121 -RRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGL 179

Query: 231 TKLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIE 290
            + +    YPQ+S ST+GSSL  +   + E      M+ + I  W      I+  A+ I 
Sbjct: 180 ERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHIL 239

Query: 291 KELKGF--DLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYT 348
           KEL  F  +   +V+I FSAH +P++ V   GDPY  E+   V  +ME+L      N Y 
Sbjct: 240 KELNHFPEEKRSEVVILFSAHSLPMSVVNR-GDPYPQEVGATVHKVMEKLG---YPNPYR 295

Query: 349 LAYQSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKE-LAL 407
           L +QS+VGPV WL P TDE I  L ++G K++L VPI+F S+HIETL E+D+EY + LA 
Sbjct: 296 LVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQ 355

Query: 408 ESGIENWGRVPALGCEPTFISDLADAV 434
           + G EN  R  +L   P F   LAD V
Sbjct: 356 KCGAENIRRAESLNGNPLFSKALADLV 382


>HEMZ_CAUCR (P57777) Ferrochelatase (EC 4.99.1.1) (Protoheme
           ferro-lyase) (Heme synthetase)
          Length = 347

 Score =  224 bits (570), Expect = 6e-58
 Identities = 133/327 (40%), Positives = 186/327 (56%), Gaps = 15/327 (4%)

Query: 114 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFSFLQKPLAQFVSVLRAPKSKEG 173
           K+ V+L NLGGP+  D V+PFLFNLF DP II  P L  +   PLA  +S  R   +K  
Sbjct: 4   KLAVVLFNLGGPDGPDAVRPFLFNLFRDPAIIGAPALIRY---PLAALISTTREKSAKAN 60

Query: 174 YASIGGGSPLRRMTDAQAEELRKSLF--EKNVPANVYVGMRYWHPFTEEAIELIKRDGIT 231
           YA +GGGSPL   T+ QA  L  +L      V A  ++ MRYWHP T+E    +      
Sbjct: 61  YAIMGGGSPLLPETEKQARALEAALALAMPGVEAKCFIAMRYWHPLTDETARQVAAFAPD 120

Query: 232 KLVVLPLYPQFSISTSGSSLRLLESIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIEK 291
           ++V+LPLYPQFS +T+GSSL+  +  ++          T +  +    G I+A A +I +
Sbjct: 121 QVVLLPLYPQFSTTTTGSSLKAWKKTYKGSGV-----QTTVGCYPTEGGLIEAHARMIRE 175

Query: 292 ELKGFDLPEKVMIFFSAHGVPVAYVEEAGDPYKAEMEECVDLIMEELEKRKITNAYTLAY 351
             +    P  + + FSAHG+P   +  AGDPY+ ++E     +   L  +     +T+ Y
Sbjct: 176 SWEKAGSPTNIRLLFSAHGLPEKVIL-AGDPYQKQVEATAAAVAAHLPPQI---EWTVCY 231

Query: 352 QSRVGPVEWLKPYTDETIIELGKKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGI 411
           QSRVGP++W+ P TD+ I   G +  K ++  PI+FVSEH+ETL E+D EY ELA E G 
Sbjct: 232 QSRVGPLKWIGPSTDDEIRRAGGED-KGVMITPIAFVSEHVETLVELDHEYAELAEEVGA 290

Query: 412 ENWGRVPALGCEPTFISDLADAVIESL 438
             + RV ALG  P FI  LA AV +S+
Sbjct: 291 APYLRVSALGTAPEFIDGLAKAVRDSV 317


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.318    0.137    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,137,232
Number of Sequences: 164201
Number of extensions: 2727657
Number of successful extensions: 7809
Number of sequences better than 10.0: 138
Number of HSP's better than 10.0 without gapping: 120
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 7314
Number of HSP's gapped (non-prelim): 153
length of query: 527
length of database: 59,974,054
effective HSP length: 115
effective length of query: 412
effective length of database: 41,090,939
effective search space: 16929466868
effective search space used: 16929466868
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)