BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC148607.1 + phase: 0 /pseudo
(296 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1 (Pleom... 108 2e-23
ABG8_HUMAN (Q9H221) ATP-binding cassette, sub-family G, member 8... 102 1e-21
CDR2_CANAL (P78595) Multidrug resistance protein CDR2 102 1e-21
ABG8_RAT (P58428) ATP-binding cassette, sub-family G, member 8 (... 102 1e-21
YOH5_YEAST (Q08234) Probable ATP-dependent transporter YOL074C/Y... 101 2e-21
PDRA_YEAST (P51533) ATP-dependent permease PDR10 101 3e-21
PDRF_YEAST (Q04182) ATP-dependent permease PDR15 100 3e-21
PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin 100 7e-21
CDR1_CANAL (P43071) Multidrug resistance protein CDR1 99 1e-20
ABG8_MOUSE (Q9DBM0) ATP-binding cassette, sub-family G, member 8... 96 8e-20
CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3 94 4e-19
ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2... 94 4e-19
CDR4_CANAL (O74676) ABC transporter CDR4 92 1e-18
ADP1_YEAST (P25371) Probable ATP-dependent permease precursor 91 3e-18
BFR1_SCHPO (P41820) Brefeldin A resistance protein 88 2e-17
ABG1_MOUSE (Q64343) ATP-binding cassette, sub-family G, member 1... 88 2e-17
YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W 88 3e-17
ABG1_HUMAN (P45844) ATP-binding cassette, sub-family G, member 1... 87 6e-17
YPC3_CAEEL (Q11180) Putative ABC transporter C05D10.3 in chromos... 86 1e-16
ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4 84 3e-16
>CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1
(Pleomorphic drug resistance homolog)
Length = 1542
Score = 108 bits (270), Expect = 2e-23
Identities = 50/156 (32%), Positives = 89/156 (57%)
Query: 75 NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLD 134
N +TD + GL DT VGN ++R +SGG++KR++ E+ + +K D + GLD
Sbjct: 280 NHVTDVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVWICGSKFQCWDNATRGLD 339
Query: 135 SSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEF 194
S+T + V +++ HI K +++ Q + YNLF+ + +L + + IY G +H +
Sbjct: 340 SATALEFVRALKTQAHIAKNVATVAIYQCSQDAYNLFNKVSVLYEGYQIYFGDAQHAKVY 399
Query: 195 FESIGFKCPNRKGVADFLQEVTSRKDQEQYWEHKDR 230
F+ +G+ CP R+ + DFL +TS ++ E+ D+
Sbjct: 400 FQKMGYFCPKRQTIPDFLTSITSPAERRINKEYLDK 435
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/196 (23%), Positives = 95/196 (47%), Gaps = 17/196 (8%)
Query: 50 KDANIKPDPDIDVYMKAVATEG-QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQK 108
K A ++ Y++ ++ +++N + V+++L +E AD VVG ++ Q+
Sbjct: 973 KTATVRESLRFSAYLRQPSSVSIEEKNEYVEAVIKILEMETYADAVVG-VPGEGLNVEQR 1031
Query: 109 KRLTTG-EMLVGPTKALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPET 167
KRLT G E+ P +F+DE ++GLDS T + M++ + + ++ ++ QP
Sbjct: 1032 KRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWATCQLMKKLANHGQ-AILCTIHQPSAML 1090
Query: 168 YNLFDDIILL-SDSHIIYQGPR----EHVLEFFESIG-FKCPNRKGVADFLQEVT----- 216
FD ++ L +Y G + ++++FE G KCP A+++ EV
Sbjct: 1091 MQEFDRLLFLQKGGQTVYFGDLGKGCKTMIKYFEDHGAHKCPPDANPAEWMLEVVGAAPG 1150
Query: 217 --SRKDQEQYWEHKDR 230
+ +D + W + ++
Sbjct: 1151 SHANQDYHEVWRNSEQ 1166
>ABG8_HUMAN (Q9H221) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 673
Score = 102 bits (254), Expect = 1e-21
Identities = 57/159 (35%), Positives = 97/159 (60%), Gaps = 8/159 (5%)
Query: 69 TEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDE 128
++ Q++ + D V+ L L CADT VGN +R +SGG+++R++ G L+ L +DE
Sbjct: 180 SQAQRDKRVED-VIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDE 238
Query: 129 ISTGLDSSTTFQIVNSMRQYVHILKGT--VVISLLQPPPETYNLFDDIILLSDSHIIYQG 186
++GLDS T +V ++ + + KG V+ISL QP + + LFD ++L++ IY G
Sbjct: 239 PTSGLDSFTAHNLVKTLSR---LAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLG 295
Query: 187 PREHVLEFFESIGFKCPNRKGVADFLQEVTS--RKDQEQ 223
+H++++F +IG+ CP ADF ++TS R+ +EQ
Sbjct: 296 AAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQ 334
>CDR2_CANAL (P78595) Multidrug resistance protein CDR2
Length = 1499
Score = 102 bits (253), Expect = 1e-21
Identities = 58/195 (29%), Positives = 103/195 (52%), Gaps = 2/195 (1%)
Query: 86 GLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQIVNSM 145
GL +T VGN +R +SGG++KR++ E + D + GLDS+T + + ++
Sbjct: 284 GLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRAL 343
Query: 146 RQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGFKCPNR 205
+ IL T +I++ Q + Y LFD++++L + + I+ G E+FE++G+KCP R
Sbjct: 344 KTSATILDTTPLIAIYQCSQDAYELFDNVVVLYEGYQIFFGKASKAKEYFENMGWKCPQR 403
Query: 206 KGVADFLQEVTSRKDQEQYWEHKDRPYRFITAEEFSEAFQTFHVGRRLGDELGTEFDKSN 265
+ ADFL +T+ ++E ++D+ R TA+EF ++ L E+ F +
Sbjct: 404 QTTADFLTSLTNPAEREPLPGYEDKVPR--TAQEFETFWKNSPEYAELTKEIDEYFVECE 461
Query: 266 SHPAALTTKKYGVGK 280
T ++ VGK
Sbjct: 462 RSNTGETYRESHVGK 476
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/163 (27%), Positives = 79/163 (47%), Gaps = 16/163 (9%)
Query: 79 DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSST 137
DYV+ +L + AD +VG A ++ Q+KRLT G E++ P LF+DE ++GLDS T
Sbjct: 976 DYVIDLLEMTDYADALVGVAG-EGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQT 1034
Query: 138 TFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGPR----EHVL 192
+ I MR+ + ++ ++ QP FD ++ L Y G + ++
Sbjct: 1035 AWSICKLMRKLADHGQ-AILCTIHQPSALIMAEFDKLLFLQKGGRTAYFGELGENCQTMI 1093
Query: 193 EFFESIGF-KCPNRKGVADFLQEVT-------SRKDQEQYWEH 227
+FE G CP A+++ +V +++D + W +
Sbjct: 1094 NYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRN 1136
>ABG8_RAT (P58428) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 694
Score = 102 bits (253), Expect = 1e-21
Identities = 57/159 (35%), Positives = 97/159 (60%), Gaps = 8/159 (5%)
Query: 69 TEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDE 128
++ Q++ + D V+ L L CA+T VGN +R +SGG+++R++ G L+ L +DE
Sbjct: 202 SQAQRDKRVED-VIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDE 260
Query: 129 ISTGLDSSTTFQIVNSMRQYVHILKGT--VVISLLQPPPETYNLFDDIILLSDSHIIYQG 186
++GLDS T +V ++ + + KG V+ISL QP + + LFD ++L++ IY G
Sbjct: 261 PTSGLDSFTAHNLVRTLSR---LAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLG 317
Query: 187 PREHVLEFFESIGFKCPNRKGVADFLQEVTS--RKDQEQ 223
+H++++F SIG+ CP ADF ++TS R+ +EQ
Sbjct: 318 VAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQ 356
>YOH5_YEAST (Q08234) Probable ATP-dependent transporter
YOL074C/YOL075C
Length = 1294
Score = 101 bits (252), Expect = 2e-21
Identities = 53/182 (29%), Positives = 100/182 (54%), Gaps = 15/182 (8%)
Query: 74 ENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGL 133
+ L+ + ++ LGL+ CADT+VG+ R +SGG+K+RL+ G ++ +F+DE +TGL
Sbjct: 157 KKLMVEQLIEELGLKDCADTLVGDNSHRGLSGGEKRRLSIGTQMISNPSIMFLDEPTTGL 216
Query: 134 DSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLE 193
D+ + F ++ ++++ T ++S+ QP + L D + +LS +++Y ++ +
Sbjct: 217 DAYSAFLVIKTLKKLAKEDGRTFIMSIHQPRSDILFLLDQVCILSKGNVVYCDKMDNTIP 276
Query: 194 FFESIGFKCPNRKGVADF---LQEVTSRKDQEQ------------YWEHKDRPYRFITAE 238
+FESIG+ P AD+ L V SR D+E+ +W +R + + AE
Sbjct: 277 YFESIGYHVPQLVNPADYFIDLSSVDSRSDKEEAATQSRLNSLIDHWHDYERTHLQLQAE 336
Query: 239 EF 240
+
Sbjct: 337 SY 338
Score = 98.2 bits (243), Expect = 2e-20
Identities = 49/154 (31%), Positives = 88/154 (56%), Gaps = 1/154 (0%)
Query: 78 TDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSST 137
TD ++R LGL+ C + ++GN ++ ISGG+K+R+T G L+ L +DE ++GLDS T
Sbjct: 814 TDNLIRSLGLKHCENNIIGNEFVKGISGGEKRRVTMGVQLLNDPPILLLDEPTSGLDSFT 873
Query: 138 TFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDS-HIIYQGPREHVLEFFE 196
+ I+ + + T++I++ QP E + F +++LL+ S + G + ++ +F
Sbjct: 874 SATILEILEKLCREQGKTIIITIHQPRSELFKRFGNVLLLAKSGRTAFNGSPDEMIAYFT 933
Query: 197 SIGFKCPNRKGVADFLQEVTSRKDQEQYWEHKDR 230
+G+ CP+ VADF ++ S Q + E R
Sbjct: 934 ELGYNCPSFTNVADFFLDLISVNTQNEQNEISSR 967
>PDRA_YEAST (P51533) ATP-dependent permease PDR10
Length = 1564
Score = 101 bits (251), Expect = 3e-21
Identities = 45/145 (31%), Positives = 84/145 (57%)
Query: 77 ITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSS 136
+T+ + GL ADT VGN +R +SGG++KR++ E+ + +K D + GLDS+
Sbjct: 303 MTEVAMATYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSA 362
Query: 137 TTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFE 196
T + + +++ I K +++ Q + Y+LFD + +L D + I+ GP + ++F+
Sbjct: 363 TALEFIKALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGYQIFFGPSKQAKKYFQ 422
Query: 197 SIGFKCPNRKGVADFLQEVTSRKDQ 221
+G+ CP R+ AD+L +TS ++
Sbjct: 423 RMGYVCPERQTTADYLTSITSPSER 447
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/175 (25%), Positives = 87/175 (49%), Gaps = 12/175 (6%)
Query: 50 KDANIKPDPDIDVYMK-AVATEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQK 108
K A ++ Y++ A ++++ + V+ VL +++ AD +VG ++ Q+
Sbjct: 1011 KTATVRESLRFSAYLRQADDVSIEEKDKYVEEVIEVLEMKLYADAIVG-VPGEGLNVEQR 1069
Query: 109 KRLTTG-EMLVGPTKALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVI-SLLQPPPE 166
KRLT G E+ P +F+DE ++GLDS T + M++ +G ++ ++ QP
Sbjct: 1070 KRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWSTCQLMKKLAS--RGQAILCTIHQPSAL 1127
Query: 167 TYNLFDDIILLSD-SHIIYQGPR----EHVLEFFESIG-FKCPNRKGVADFLQEV 215
FD ++ L + +Y G + ++ +FE+ G KCP A+++ E+
Sbjct: 1128 LMQEFDRLLFLQEGGQTVYFGELGKGCKTMINYFEAHGAHKCPPDANPAEWMLEI 1182
>PDRF_YEAST (Q04182) ATP-dependent permease PDR15
Length = 1529
Score = 100 bits (250), Expect = 3e-21
Identities = 45/143 (31%), Positives = 82/143 (56%)
Query: 75 NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLD 134
N +T+ + GL DT VGN ++R +SGG++KR++ E+ + + D + GLD
Sbjct: 291 NHVTEVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGLD 350
Query: 135 SSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEF 194
S+T + + +++ I K +++ Q + Y+LFD + +L D + +Y GP + ++
Sbjct: 351 SATALEFIRALKTQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQLYFGPAKDAKKY 410
Query: 195 FESIGFKCPNRKGVADFLQEVTS 217
F+ +G+ CP R+ ADFL +TS
Sbjct: 411 FQDMGYYCPPRQTTADFLTSITS 433
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/204 (25%), Positives = 99/204 (48%), Gaps = 18/204 (8%)
Query: 50 KDANIKPDPDIDVYMKAVATEG-QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQK 108
K A ++ Y++ ++ +++N + V+++L ++ +D VVG A ++ Q+
Sbjct: 972 KTATVRESLRFSAYLRQPSSVSIEEKNRYVEEVIKILEMQQYSDAVVGVAG-EGLNVEQR 1030
Query: 109 KRLTTG-EMLVGPTKALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPET 167
KRLT G E+ P +F+DE ++GLDS T + MR+ + ++ ++ QP
Sbjct: 1031 KRLTIGVELAARPKLLVFLDEPTSGLDSQTAWDTCQLMRK-LATHGQAILCTIHQPSAIL 1089
Query: 168 YNLFDDIILL-SDSHIIYQGPR----EHVLEFFESIG-FKCPNRKGVADFLQEVT----- 216
FD ++ L +Y G + ++++FES G KCP A+++ EV
Sbjct: 1090 MQQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFESKGAHKCPPDANPAEWMLEVVGAAPG 1149
Query: 217 --SRKDQEQYWEHKDRPYRFITAE 238
+ +D + W + D Y+ + E
Sbjct: 1150 SHATQDYNEVWRNSDE-YKAVQEE 1172
>PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin
Length = 1511
Score = 99.8 bits (247), Expect = 7e-21
Identities = 45/147 (30%), Positives = 85/147 (57%)
Query: 75 NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLD 134
N + + + GL +T VGN ++R +SGG++KR++ E+ + +K D + GLD
Sbjct: 281 NHLAEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLD 340
Query: 135 SSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEF 194
S+T + + +++ I + +++ Q + Y+LF+ + +L D + IY GP + ++
Sbjct: 341 SATALEFIRALKTQADISNTSATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKAKKY 400
Query: 195 FESIGFKCPNRKGVADFLQEVTSRKDQ 221
FE +G+ CP+R+ ADFL VTS ++
Sbjct: 401 FEDMGYVCPSRQTTADFLTSVTSPSER 427
Score = 61.2 bits (147), Expect = 3e-09
Identities = 53/204 (25%), Positives = 101/204 (48%), Gaps = 18/204 (8%)
Query: 50 KDANIKPDPDIDVYMKAVATEG-QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQK 108
K A ++ Y++ A +++N + V+++L +E AD VVG A ++ Q+
Sbjct: 957 KTATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAG-EGLNVEQR 1015
Query: 109 KRLTTG-EMLVGPTKALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPET 167
KRLT G E+ P +F+DE ++GLDS T + I M++ + + ++ ++ QP
Sbjct: 1016 KRLTIGVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQ-AILCTIHQPSAIL 1074
Query: 168 YNLFDDIILLS-DSHIIYQGPR----EHVLEFFESIG-FKCPNRKGVADFLQEVT----- 216
FD ++ + +Y G + ++++FES G KCP A+++ EV
Sbjct: 1075 MQEFDRLLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPG 1134
Query: 217 --SRKDQEQYWEHKDRPYRFITAE 238
+ +D + W + + YR + +E
Sbjct: 1135 SHANQDYYEVWRNSEE-YRAVQSE 1157
>CDR1_CANAL (P43071) Multidrug resistance protein CDR1
Length = 1501
Score = 99.0 bits (245), Expect = 1e-20
Identities = 57/184 (30%), Positives = 100/184 (53%), Gaps = 5/184 (2%)
Query: 86 GLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQIVNSM 145
GL +T VGN +R +SGG++KR++ E + D + GLDS+T + + ++
Sbjct: 286 GLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRAL 345
Query: 146 RQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGFKCPNR 205
+ IL T +I++ Q + Y+LFD +++L + + I+ G E+FE +G+KCP R
Sbjct: 346 KTSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQR 405
Query: 206 KGVADFLQEVTSRKDQEQYWEHKDRPYRFITAEEFSEAFQTFHVGRRLG---DELGTEFD 262
+ ADFL +T+ ++E ++D+ R TA+EF ++ L DE E +
Sbjct: 406 QTTADFLTSLTNPAEREPLPGYEDKVPR--TAQEFETYWKNSPEYAELTKEIDEYFVECE 463
Query: 263 KSNS 266
+SN+
Sbjct: 464 RSNT 467
Score = 51.2 bits (121), Expect = 3e-06
Identities = 45/163 (27%), Positives = 79/163 (47%), Gaps = 16/163 (9%)
Query: 79 DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSST 137
DYV+ +L + AD +VG A ++ Q+KRLT G E++ P LF+DE ++GLDS T
Sbjct: 978 DYVIDLLEMTDYADALVGVAG-EGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQT 1036
Query: 138 TFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGPR----EHVL 192
+ I MR+ + ++ ++ QP FD ++ L Y G + ++
Sbjct: 1037 AWSICKLMRKLADHGQ-AILCTIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMI 1095
Query: 193 EFFESIGF-KCPNRKGVADFLQEVT-------SRKDQEQYWEH 227
+FE G CP A+++ +V +++D + W +
Sbjct: 1096 NYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRN 1138
>ABG8_MOUSE (Q9DBM0) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 673
Score = 96.3 bits (238), Expect = 8e-20
Identities = 55/159 (34%), Positives = 95/159 (59%), Gaps = 8/159 (5%)
Query: 69 TEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDE 128
++ Q++ + D V+ L L CA+T VGN +R +SGG+++R++ G L+ L +DE
Sbjct: 181 SQAQRDKRVED-VIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDE 239
Query: 129 ISTGLDSSTTFQIVNSMRQYVHILKGT--VVISLLQPPPETYNLFDDIILLSDSHIIYQG 186
++GLDS T +V ++ + + KG V+ISL QP + + LFD ++L++ IY G
Sbjct: 240 PTSGLDSFTAHNLVTTLSR---LAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLG 296
Query: 187 PREHVLEFFESIGFKCPNRKGVADFLQEVTS--RKDQEQ 223
+ ++++F SIG CP ADF ++TS R+ +E+
Sbjct: 297 AAQQMVQYFTSIGHPCPRYSNPADFYVDLTSIDRRSKER 335
>CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3
Length = 1501
Score = 94.0 bits (232), Expect = 4e-19
Identities = 46/141 (32%), Positives = 79/141 (55%)
Query: 77 ITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSS 136
+ D V+ GL +T VGN IR ISGG++KRL+ E+ + D + GLD++
Sbjct: 268 VVDVVMATYGLSHTKNTKVGNDFIRGISGGERKRLSIAEVTLVQASIQCWDNSTRGLDAA 327
Query: 137 TTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFE 196
T + ++S++ IL T +I++ Q Y+LFD +I++ + + I+ G + +F+
Sbjct: 328 TALEFISSLKTSASILNDTPLIAIYQCSQNAYDLFDKVIVMYEGYQIFFGSSQRAAAYFK 387
Query: 197 SIGFKCPNRKGVADFLQEVTS 217
+GF C +R+ DFL +TS
Sbjct: 388 KMGFVCQDRQTTPDFLTSITS 408
Score = 48.9 bits (115), Expect = 1e-05
Identities = 37/138 (26%), Positives = 69/138 (49%), Gaps = 8/138 (5%)
Query: 81 VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTF 139
++ +L + D +VG ++ Q+KRLT E++ P +F+DE ++GLDS T +
Sbjct: 961 IIDLLEMRTYVDAIVG-VPGEGLNVEQRKRLTIAVELVARPKLLVFLDEPTSGLDSQTAW 1019
Query: 140 QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGP----REHVLEFF 195
I +R+ + + ++ ++ QP FD ++LL +Y G ++E+F
Sbjct: 1020 SICKLIRKLANHGQ-AILCTIHQPSAILLEEFDRLLLLQKGETVYFGEFGANCHTLIEYF 1078
Query: 196 ESIG-FKCPNRKGVADFL 212
E G KCP A+++
Sbjct: 1079 ERNGASKCPQHANPAEWM 1096
>ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2
(Placenta-specific ATP-binding cassette transporter)
(Breast cancer resistance protein)
Length = 655
Score = 94.0 bits (232), Expect = 4e-19
Identities = 50/150 (33%), Positives = 83/150 (55%), Gaps = 1/150 (0%)
Query: 66 AVATEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALF 125
A ++N + V+ LGL+ AD+ VG IR +SGG++KR + G L+ LF
Sbjct: 149 ATTMTNHEKNERINRVIEELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILF 208
Query: 126 MDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQ 185
+DE +TGLDSST ++ +++ + T++ S+ QP + LFD + LL+ +++
Sbjct: 209 LDEPTTGLDSSTANAVLLLLKR-MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFH 267
Query: 186 GPREHVLEFFESIGFKCPNRKGVADFLQEV 215
GP + L +FES G+ C ADF ++
Sbjct: 268 GPAQEALGYFESAGYHCEAYNNPADFFLDI 297
>CDR4_CANAL (O74676) ABC transporter CDR4
Length = 1490
Score = 92.4 bits (228), Expect = 1e-18
Identities = 43/137 (31%), Positives = 79/137 (57%)
Query: 81 VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQ 140
V+ V GL +T VGN IR +SGG++KR++ E+ + D + GLDS+T +
Sbjct: 284 VMAVYGLSHTRNTKVGNDFIRGVSGGERKRVSIAEITLNNAMVQCWDNSTRGLDSATALE 343
Query: 141 IVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGF 200
+ +++ I+ T ++++ Q + Y+LFD ++L+ + IY G + ++F +G+
Sbjct: 344 FIRALKASADIVHTTPLVAIYQCSQDAYDLFDKVVLMYQGYQIYFGSAKKAKQYFIDMGY 403
Query: 201 KCPNRKGVADFLQEVTS 217
+CP R+ ADFL +T+
Sbjct: 404 ECPQRQTTADFLTSLTN 420
Score = 57.8 bits (138), Expect = 3e-08
Identities = 52/175 (29%), Positives = 88/175 (49%), Gaps = 15/175 (8%)
Query: 63 YMKAVATEGQKE-NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPT 121
Y++ + +KE N DY++R+L +E AD VVG + ++ Q+KRL+ G LV
Sbjct: 948 YLRQPKSVSRKEKNEYVDYIIRLLEMEQYADAVVGVSG-EGLNVEQRKRLSIGVELVAKP 1006
Query: 122 KAL-FMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLS-D 179
K L F+DE ++GLDS T + I +R+ + ++ ++ QP FD ++ L
Sbjct: 1007 KLLVFLDEPTSGLDSQTAWSICKLIRKLADNGQ-AILCTIHQPSAILLAEFDRLLFLQRG 1065
Query: 180 SHIIYQGPR----EHVLEFFESIGF-KCPNRKGVADFLQEVT-----SRKDQEQY 224
+Y G ++ +FE G KCP A+++ EV S+ +Q+ Y
Sbjct: 1066 GQTVYFGDLGKNFTTLINYFEKYGAPKCPPEANPAEWMLEVIGAAPGSKANQDYY 1120
>ADP1_YEAST (P25371) Probable ATP-dependent permease precursor
Length = 1049
Score = 91.3 bits (225), Expect = 3e-18
Identities = 50/152 (32%), Positives = 85/152 (55%), Gaps = 2/152 (1%)
Query: 65 KAVATEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKAL 124
KA++ E +K + VL L + D ++GN R ISGG+K+R++ LV L
Sbjct: 494 KALSFEAKKARVYK--VLEELRIIDIKDRIIGNEFDRGISGGEKRRVSIACELVTSPLVL 551
Query: 125 FMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIY 184
F+DE ++GLD+S ++ + + T+V+S+ QP + LFD ++LLS ++Y
Sbjct: 552 FLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVY 611
Query: 185 QGPREHVLEFFESIGFKCPNRKGVADFLQEVT 216
G + V EF + G+ CP+ +AD+L ++T
Sbjct: 612 SGNAKKVSEFLRNEGYICPDNYNIADYLIDIT 643
>BFR1_SCHPO (P41820) Brefeldin A resistance protein
Length = 1530
Score = 88.2 bits (217), Expect = 2e-17
Identities = 58/183 (31%), Positives = 89/183 (47%), Gaps = 3/183 (1%)
Query: 81 VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQ 140
+ GL +T VGN +R +SGG++KR+T E D + GLDSST F+
Sbjct: 287 IATAFGLTHTFNTKVGNDFVRGVSGGERKRVTISEGFATRPTIACWDNSTRGLDSSTAFE 346
Query: 141 IVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGF 200
VN +R + LK T ++ Q + Y LFD I +L IY GP + ++F +GF
Sbjct: 347 FVNVLRTCANELKMTSFVTAYQASEKIYKLFDRICVLYAGRQIYYGPADKAKQYFLDMGF 406
Query: 201 KCPNRKGVADFLQEVTSRKDQEQYWEHKDRPYRFITAEEFSEAFQTFHVGRRLGDELGTE 260
C R+ DFL ++ K + ++R R T +EF + ++ V L E+
Sbjct: 407 DCHPRETTPDFLTAISDPKARFPRKGFENRVPR--TPDEFEQMWRNSSVYADLMAEM-ES 463
Query: 261 FDK 263
+DK
Sbjct: 464 YDK 466
Score = 56.6 bits (135), Expect = 7e-08
Identities = 45/163 (27%), Positives = 85/163 (51%), Gaps = 16/163 (9%)
Query: 81 VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTF 139
V+++L +E A+ ++G ++ Q+KR T G E+ P LF+DE ++GLDS + +
Sbjct: 1002 VIKLLEMESYAEAIIGTPG-SGLNVEQRKRATIGVELAAKPALLLFLDEPTSGLDSQSAW 1060
Query: 140 QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGP-REH---VLEF 194
IV +R+ + ++ ++ QP ++ FD ++LL +Y G EH +L +
Sbjct: 1061 SIVCFLRKLADAGQ-AILCTIHQPSAVLFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNY 1119
Query: 195 FESIG-FKCPNRKGVADFLQEV-------TSRKDQEQYWEHKD 229
FES G CP+ A+++ +V T+ +D + W + +
Sbjct: 1120 FESHGAVHCPDDGNPAEYILDVIGAGATATTNRDWHEVWNNSE 1162
>ABG1_MOUSE (Q64343) ATP-binding cassette, sub-family G, member 1
(White protein homolog) (ATP-binding cassette
transporter 8)
Length = 666
Score = 88.2 bits (217), Expect = 2e-17
Identities = 51/154 (33%), Positives = 86/154 (55%), Gaps = 8/154 (5%)
Query: 70 EGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEI 129
EG++E + +L LGL CA+T G+ +SGGQ+KRL LV +F DE
Sbjct: 191 EGRRE--MVKEILTALGLLPCANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEP 243
Query: 130 STGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPRE 189
++GLDS++ FQ+V+ M+ + ++V ++ QP + + LFD + +LS +Y+G
Sbjct: 244 TSGLDSASCFQVVSLMKGLAQGGR-SIVCTIHQPSAKLFELFDQLYVLSQGQCVYRGKVS 302
Query: 190 HVLEFFESIGFKCPNRKGVADFLQEVTSRKDQEQ 223
+++ + +G CP ADF+ EV S + +Q
Sbjct: 303 NLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQ 336
>YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W
Length = 1333
Score = 87.8 bits (216), Expect = 3e-17
Identities = 45/147 (30%), Positives = 76/147 (51%), Gaps = 3/147 (2%)
Query: 73 KENLIT---DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEI 129
KE IT ++ ++ GL DT VGN I +SGG++KR++ E L D
Sbjct: 147 KEEYITANREFYAKIFGLTHTFDTKVGNDFISGVSGGERKRVSIAEALAAKGSIYCWDNA 206
Query: 130 STGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPRE 189
+ GLDSST + ++R ++L T ++++ Q Y FD + +L I+ G
Sbjct: 207 TRGLDSSTALEFARAIRTMTNLLGTTALVTVYQASENIYETFDKVTVLYAGRQIFCGKTT 266
Query: 190 HVLEFFESIGFKCPNRKGVADFLQEVT 216
++FE++G+ CP R+ A++L +T
Sbjct: 267 EAKDYFENMGYLCPPRQSTAEYLTAIT 293
Score = 50.4 bits (119), Expect = 5e-06
Identities = 37/141 (26%), Positives = 76/141 (53%), Gaps = 9/141 (6%)
Query: 81 VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVG-PTKALFMDEISTGLDSSTTF 139
++ +L ++ ++ +VG ++ Q+K+L+ G LVG P LF+DE ++GLDS + +
Sbjct: 848 IISILEMQEFSEALVGEIGY-GLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQSAW 906
Query: 140 QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGP----REHVLEF 194
+V +++ + + +++ ++ QP + FD ++LL IY G V+++
Sbjct: 907 AVVKMLKR-LALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIKY 965
Query: 195 FESIGF-KCPNRKGVADFLQE 214
FE G KC + A+++ E
Sbjct: 966 FEKNGARKCQQNENPAEYILE 986
>ABG1_HUMAN (P45844) ATP-binding cassette, sub-family G, member 1
(White protein homolog) (ATP-binding cassette
transporter 8)
Length = 678
Score = 86.7 bits (213), Expect = 6e-17
Identities = 50/154 (32%), Positives = 86/154 (55%), Gaps = 8/154 (5%)
Query: 70 EGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEI 129
EG++E + +L LGL CA+T G+ +SGGQ+KRL LV +F DE
Sbjct: 191 EGRRE--MVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEP 243
Query: 130 STGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPRE 189
++GLDS++ FQ+V+ M+ + +++ ++ QP + + LFD + +LS +Y+G
Sbjct: 244 TSGLDSASCFQVVSLMKGLAQGGR-SIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVC 302
Query: 190 HVLEFFESIGFKCPNRKGVADFLQEVTSRKDQEQ 223
+++ + +G CP ADF+ EV S + +Q
Sbjct: 303 NLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQ 336
>YPC3_CAEEL (Q11180) Putative ABC transporter C05D10.3 in chromosome
III
Length = 598
Score = 85.9 bits (211), Expect = 1e-16
Identities = 49/142 (34%), Positives = 80/142 (55%), Gaps = 4/142 (2%)
Query: 73 KENLITDYVLRVLGLEICADTVVGNA-MIRAISGGQKKRLTTGEMLVGPTKALFMDEIST 131
+ L + VL +GL+ CADTV+G ++ +S G+KKRL+ ++ K LF DE ++
Sbjct: 106 ERQLRVEQVLTQMGLKKCADTVIGIPNQLKGLSCGEKKRLSFASEILTCPKILFCDEPTS 165
Query: 132 GLDSSTTFQIVNSMRQYVHILKG-TVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREH 190
GLD+ +V ++R G TV+I++ QP Y+LF+++ L++ +IY GP +
Sbjct: 166 GLDAFMAGHVVQALRSLAD--NGMTVIITIHQPSSHVYSLFNNVCLMACGRVIYLGPGDQ 223
Query: 191 VLEFFESIGFKCPNRKGVADFL 212
+ FE G+ CP AD L
Sbjct: 224 AVPLFEKCGYPCPAYYNPADHL 245
>ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4
Length = 646
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/158 (30%), Positives = 85/158 (53%), Gaps = 7/158 (4%)
Query: 60 IDVYMKAVATEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVG 119
+ +K + K+ L+T+ +L LGL C+ T +SGGQ+KRL LV
Sbjct: 164 VSANLKLSEKQEVKKELVTE-ILTALGLMSCSHTRTA-----LLSGGQRKRLAIALELVN 217
Query: 120 PTKALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSD 179
+F DE ++GLDS++ FQ+V+ M+ + T++ ++ QP + + +FD + +LS
Sbjct: 218 NPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGR-TIICTIHQPSAKLFEMFDKLYILSQ 276
Query: 180 SHIIYQGPREHVLEFFESIGFKCPNRKGVADFLQEVTS 217
I++G +++ + + +G CP ADF+ EV S
Sbjct: 277 GQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVAS 314
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.327 0.141 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,689,683
Number of Sequences: 164201
Number of extensions: 1354686
Number of successful extensions: 4466
Number of sequences better than 10.0: 523
Number of HSP's better than 10.0 without gapping: 313
Number of HSP's successfully gapped in prelim test: 210
Number of HSP's that attempted gapping in prelim test: 4023
Number of HSP's gapped (non-prelim): 619
length of query: 296
length of database: 59,974,054
effective HSP length: 109
effective length of query: 187
effective length of database: 42,076,145
effective search space: 7868239115
effective search space used: 7868239115
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Medicago: description of AC148607.1