BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC148469.7 - phase: 0 
         (540 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

VAC8_YEAST (P39968) Vacuolar protein 8                                 86  2e-16
ARM_MUSDO (Q02453) Armadillo segment polarity protein                  61  6e-09
PLAK_BOVIN (Q8SPJ1) Junction plakoglobin (Desmoplakin III)             61  8e-09
CTNB_XENLA (P26233) Beta-catenin                                       60  1e-08
IMA1_MOUSE (Q60960) Importin alpha-1 subunit (Karyopherin alpha-...    60  1e-08
PLAK_MOUSE (Q02257) Junction plakoglobin (Desmoplakin III) (Frag...    59  2e-08
ARM_DROME (P18824) Armadillo segment polarity protein                  59  3e-08
IMA2_ARATH (O04294) Importin alpha-2 subunit (Karyopherin alpha-...    58  5e-08
CTNB_RAT (Q9WU82) Beta-catenin                                         58  7e-08
PLAK_HUMAN (P14923) Junction plakoglobin (Desmoplakin III)             57  9e-08
CTNB_MOUSE (Q02248) Beta-catenin                                       57  9e-08
CTNB_HUMAN (P35222) Beta-catenin (PRO2286)                             57  9e-08
IMA1_YEAST (Q02821) Importin alpha subunit (Karyopherin alpha su...    55  5e-07
IMA1_SCHPO (O14063) Importin alpha subunit (Karyopherin alpha su...    55  6e-07
PLAK_XENLA (P30998) Junction plakoglobin (Desmoplakin III)             50  2e-05
IMA_DROME (P52295) Importin alpha subunit (Karyopherin alpha sub...    48  6e-05
IMA2_XENLA (P52171) Importin alpha-2 subunit (Karyopherin alpha-...    47  2e-04
CTNB_TRIGR (P35223) Beta-catenin                                       46  3e-04
IMA_LYCES (O22478) Importin alpha subunit (Karyopherin alpha sub...    45  4e-04
IMA1_XENLA (P52170) Importin alpha-1 subunit (Karyopherin alpha-...    45  5e-04

>VAC8_YEAST (P39968) Vacuolar protein 8
          Length = 578

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 59/247 (23%), Positives = 133/247 (52%), Gaps = 7/247 (2%)

Query: 232 NIEQPTGLTNGKIKKSDGSFRDVTGDIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRST 291
           N+++   L   +I  ++   R V+ ++  +E ++  L  +  +   AA A + +L+  + 
Sbjct: 62  NLQRSAALAFAEI--TEKYVRQVSREV--LEPILILLQSQDPQIQVAACAALGNLAVNN- 116

Query: 292 DNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIMLAGAIPSIVQVL 351
           +N++LI E G +  L++ +  ++V  Q NAV  I NL+  ++NK  I  +GA+  + ++ 
Sbjct: 117 ENKLLIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLA 176

Query: 352 RAGTMEARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLC 411
           ++  +  + NA   L +++ ++EN+  +  +GA+  LV LL +  P  +    TAL N+ 
Sbjct: 177 KSKHIRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIA 236

Query: 412 IYQGNKGRAIRA--GIITALLNMLTDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPV 469
           + + N+ +  +    +++ L++++   S  +  +A   +  LAS    ++ IV+A  +P 
Sbjct: 237 VDEANRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPH 296

Query: 470 LIDLLRT 476
           L+ L+++
Sbjct: 297 LVKLIQS 303



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 68/283 (24%), Positives = 119/283 (42%), Gaps = 50/283 (17%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQE 319
           A+  L +    + +   R A   + +++  S +NR  +  AGA+PVLVSLL+S D   Q 
Sbjct: 168 ALIPLTKLAKSKHIRVQRNATGALLNMT-HSEENRKELVNAGAVPVLVSLLSSTDPDVQY 226

Query: 320 NAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRA--GTMEARENAAATLFSLSLADEN-- 375
              T++ N+++ E N+    LA   P +V  L +   +  +R    ATL   +LA +   
Sbjct: 227 YCTTALSNIAVDEANRK--KLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSY 284

Query: 376 KIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAIRAGIITALLNMLT- 434
           ++ I  +G +  LV L+Q+ S      +   + N+ I+  N+G  + AG +  L+ +L  
Sbjct: 285 QLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDY 344

Query: 435 ------------------------------------------DSSKSMVDEALTIMSVLA 452
                                                     DS  S+  E     ++LA
Sbjct: 345 KDSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILA 404

Query: 453 SHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALCKR 495
               +K+ +++A+ +  LI +  +       NAAA L  LC R
Sbjct: 405 LADVSKLDLLEANILDALIPMTFSQNQEVSGNAAAALANLCSR 447



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 51/206 (24%), Positives = 97/206 (46%), Gaps = 3/206 (1%)

Query: 261 IETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQEN 320
           +  LV  +   S      A   +R+L+   T  ++ I  AG +P LV L+ S+ +     
Sbjct: 253 VSKLVSLMDSPSSRVKCQATLALRNLAS-DTSYQLEIVRAGGLPHLVKLIQSDSIPLVLA 311

Query: 321 AVTSILNLSIYENNKGLIMLAGAIPSIVQVL-RAGTMEARENAAATLFSLSLADE-NKII 378
           +V  I N+SI+  N+GLI+ AG +  +V++L    + E + +A +TL +L+ + E N+  
Sbjct: 312 SVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRNLAASSEKNRKE 371

Query: 379 IGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAIRAGIITALLNMLTDSSK 438
              SGA+    +L  +     + + +     L +   +K   + A I+ AL+ M    ++
Sbjct: 372 FFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILDALIPMTFSQNQ 431

Query: 439 SMVDEALTIMSVLASHQEAKVSIVKA 464
            +   A   ++ L S       I++A
Sbjct: 432 EVSGNAAAALANLCSRVNNYTKIIEA 457



 Score = 37.4 bits (85), Expect = 0.100
 Identities = 34/150 (22%), Positives = 66/150 (43%), Gaps = 1/150 (0%)

Query: 385 ISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAIRAGIITALLNMLTDSSKSMVDEA 444
           +  ++ LLQ+  P+ +  A  AL NL +   NK   +  G +  L+N +   +  +   A
Sbjct: 87  LEPILILLQSQDPQIQVAACAALGNLAVNNENKLLIVEMGGLEPLINQMMGDNVEVQCNA 146

Query: 445 LTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCIS 504
           +  ++ LA+  + K  I  +  +  L  L ++   R + NA   LL +   + +N   + 
Sbjct: 147 VGCITNLATRDDNKHKIATSGALIPLTKLAKSKHIRVQRNATGALLNMTHSE-ENRKELV 205

Query: 505 RLGAVIPLSELARTGTERAKRKATSLLEHL 534
             GAV  L  L  +     +   T+ L ++
Sbjct: 206 NAGAVPVLVSLLSSTDPDVQYYCTTALSNI 235


>ARM_MUSDO (Q02453) Armadillo segment polarity protein
          Length = 813

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 75/302 (24%), Positives = 134/302 (43%), Gaps = 17/302 (5%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKLS-CRSVEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S   +T     +  LVR +S    +E ++AAV  + +LS       + I ++G
Sbjct: 175 QLSKKEASRHAITNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHR-QGLLAIFKSG 233

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV LL+S        A+T++ NL ++++ +K  + LAG +  +V +L+   ++   
Sbjct: 234 GIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLA 293

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQN-GSPRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II ASG  + LV ++++    +     +  L  L +   NK 
Sbjct: 294 IVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKP 353

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGL 478
             + AG + AL   L++ S  +V   L  +  L+       +  K   +  L+  L   L
Sbjct: 354 AIVDAGGMQALAMHLSNPSPRLVQNCLWTLRNLSD------AATKVDGLEPLLQSLVQVL 407

Query: 479 PRNKEN----AAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAK--RKATSLLE 532
                N    AA IL  L   +  N + + ++G V  L        +R +    A   L 
Sbjct: 408 ASTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALR 467

Query: 533 HL 534
           HL
Sbjct: 468 HL 469



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 35/139 (25%), Positives = 64/139 (45%), Gaps = 2/139 (1%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLT-SEDVMTQ 318
           AI  L++ L+         A   +  LSK+      +      +  LV  ++ S D+ + 
Sbjct: 150 AIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAITNSPQMVAALVRAISNSNDLEST 209

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSL-ADENKI 377
           + AV ++ NLS +      I  +G IP++V++L +        A  TL +L L  D +K+
Sbjct: 210 KAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKM 269

Query: 378 IIGASGAISALVDLLQNGS 396
            +  +G +  +V LLQ  +
Sbjct: 270 AVRLAGGLQKMVTLLQRNN 288



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 22/278 (7%)

Query: 261 IETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQ-- 318
           +++LV+ L+   V     A   + +L+  +  N+  + + G +  LV  + +     +  
Sbjct: 400 LQSLVQVLASTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEIT 459

Query: 319 ENAVTSILNLSIY----ENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLF-SLSLAD 373
           E AV ++ +L+      E  +  + L   +  IV++L   +      AA  L  +L+L  
Sbjct: 460 EPAVCALRHLTTRHADSEMAQNAVRLNYGLSVIVKLLHPPSRWPLIKAAIGLVRNLALCP 519

Query: 374 ENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAIRAGIITALLNML 433
            N   +   GAI  LV LL     R  +D      ++      +  A   G+        
Sbjct: 520 ANAAPLREHGAIHHLVRLLM----RAFQDTERQRSSVATTGSQQPAAYADGV-------- 567

Query: 434 TDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALC 493
               + +V+  +  + +LA     +  I + S IP+ + LL   +   +  AA +L  L 
Sbjct: 568 --RMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELA 625

Query: 494 KRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
             D +    I + GA  PL++L  +  E     A ++L
Sbjct: 626 -ADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVL 662


>PLAK_BOVIN (Q8SPJ1) Junction plakoglobin (Desmoplakin III)
          Length = 745

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 66/253 (26%), Positives = 117/253 (46%), Gaps = 13/253 (5%)

Query: 232 NIEQPTGLTNG-----KIKKSDGSFRDVTGDIAAIETLVRKLSCRS-VEESRAAVAEIRS 285
           N E P  +T       ++ K + S R + G    +  +VR +   S ++ +R   + + +
Sbjct: 152 NDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHN 211

Query: 286 LSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAI 344
           LS    +  + I ++G IP LV +L+S        A+T++ NL +Y E  K  + LA  +
Sbjct: 212 LSHHR-EGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGL 270

Query: 345 PSIVQVLRAGTMEARENAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKD 402
             +V +L     +        L  L+  + E+K+II A+G   ALV +++N S  +    
Sbjct: 271 QKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWT 330

Query: 403 AATALFNLCIYQGNKGRAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKV 459
            +  L  L +   NK   + AG + AL   LT +S  +V   L     +S +A+ QE   
Sbjct: 331 TSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLE 390

Query: 460 SIVKASTIPVLID 472
           S++K     + +D
Sbjct: 391 SVLKILVNQLSVD 403



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 66/304 (21%), Positives = 124/304 (40%), Gaps = 33/304 (10%)

Query: 257 DIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVM 316
           +   ++ L + L+  S    +  +  +R+LS  +T    L      + +LV+ L+ +DV 
Sbjct: 350 EAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGL---ESVLKILVNQLSVDDVN 406

Query: 317 TQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQ-VLRAGTME-ARENAAATLFSLSL-- 371
               A  ++ NL+   + NK L+     + +++  +LRAG  +   E A   L  L+   
Sbjct: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRH 466

Query: 372 --ADENKIIIGASGAISALVDLLQNGSPRGKKDAATALF-NLCIYQGNKGRAIRAGIITA 428
             A+  +  +  +  I A+V LL   +      A   L  NL +   N      A +I  
Sbjct: 467 PEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPR 526

Query: 429 LLNMLTDSSKS---------------------MVDEALTIMSVLASHQEAKVSIVKASTI 467
           L+ +L  + +                      +V+     + +LA     ++ I + +TI
Sbjct: 527 LVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTI 586

Query: 468 PVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAKRKA 527
           P+ + LL + +   +  AA +L  L  +D +    I   GA  PL EL  +  E     A
Sbjct: 587 PLFVQLLYSSVENIQRVAAGVLCELA-QDKEAADAIDAEGASAPLMELLHSRNEGTATYA 645

Query: 528 TSLL 531
            ++L
Sbjct: 646 AAVL 649



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 46/180 (25%), Positives = 79/180 (43%), Gaps = 8/180 (4%)

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIM----LAGAIPSIVQVLRAGTME 357
           A+P L  LL  ED +    A   +  LS  E ++  +M    L  A+   +Q      ++
Sbjct: 143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQ--NTSDLD 200

Query: 358 ARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNK 417
                 + L +LS   E  + I  SG I ALV +L +        A T L NL +YQ   
Sbjct: 201 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 260

Query: 418 GRAIR-AGIITALLNMLTDSSKSMVDEALTIMSVLA-SHQEAKVSIVKASTIPVLIDLLR 475
             A+R A  +  ++ +L  ++   +      + +LA  +QE+K+ I+       L+ ++R
Sbjct: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320


>CTNB_XENLA (P26233) Beta-catenin
          Length = 781

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 78/306 (25%), Positives = 132/306 (42%), Gaps = 15/306 (4%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKL-SCRSVEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S   +      +  +VR + +   VE +R     + +LS    +  + I ++G
Sbjct: 177 QLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR-EGLLAIFKSG 235

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV +L S        A+T++ NL ++ E  K  + LAG +  +V +L    ++   
Sbjct: 236 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLA 295

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II ASG   ALV++++  S  +     +  L  L +   NK 
Sbjct: 296 ITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYSYEKLLWTTSRVLKVLSVCSSNKP 355

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKVSIVKASTIPVLIDLLR 475
             + AG + AL   LTDSS+ +V   L     +S  A+ QE    +     +  L+ LL 
Sbjct: 356 AIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSDAATKQEGMEGL-----LGTLVQLLG 410

Query: 476 TGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPL--SELARTGTERAKRKATSLLEH 533
           +        AA IL  L   +  N   + ++G +  L  + L     E     A   L H
Sbjct: 411 SDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRH 470

Query: 534 LRKLQQ 539
           L    Q
Sbjct: 471 LTSRHQ 476



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 34/279 (12%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYE-NNKGLIMLA 341
           +R+LS  +T    +    G +  LV LL S+D+     A   + NL+     NK ++   
Sbjct: 385 LRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 342 GAIPSIVQ-VLRAGTME-ARENAAATLFSLSL----ADENKIIIGASGAISALVDLLQNG 395
           G I ++V+ VLRAG  E   E A   L  L+     A+  +  +     +  +V LL   
Sbjct: 442 GGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP 501

Query: 396 SPRGKKDAATALF-NLCIYQGNKGRAIRAGIITALLNMLTDSSKS--------------- 439
           S      A   L  NL +   N       G I  L+ +L  + +                
Sbjct: 502 SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSIGGTQQQFV 561

Query: 440 -------MVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLAL 492
                  +V+     + +LA     ++ I   +TIP+ + LL + +  N +  AA +L  
Sbjct: 562 EGVRMEEIVEGCTGALHILARDIHNRIVIRGLNTIPLFVQLLYSPI-ENIQRVAAGVLCD 620

Query: 493 CKRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
             +D +    I   GA  PL+EL  +  E     A ++L
Sbjct: 621 VAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL 659



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 58/258 (22%), Positives = 103/258 (39%), Gaps = 6/258 (2%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLV-SLLTSEDVMTQ 318
           AI  L + L+         A   +  LSK+      ++     +  +V ++  + DV T 
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADEN-KI 377
                ++ NLS +      I  +G IP++V++L +        A  TL +L L  E  K+
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271

Query: 378 IIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAI--RAGIITALLN-MLT 434
            +  +G +  +V LL   + +      T    +  Y   + + I   +G   AL+N M T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLA-ITTDCLQILAYGNQESKLIILASGGPQALVNIMRT 330

Query: 435 DSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALCK 494
            S + ++     ++ VL+     K +IV+A  +  L   L     R  +N    L  L  
Sbjct: 331 YSYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDSSQRLVQNCLWTLRNLSD 390

Query: 495 RDTDNLSCISRLGAVIPL 512
             T        LG ++ L
Sbjct: 391 AATKQEGMEGLLGTLVQL 408


>IMA1_MOUSE (Q60960) Importin alpha-1 subunit (Karyopherin alpha-1
           subunit) (SRP1-beta) (RAG cohort protein 2)
           (Nucleoprotein interactor 1) (Importin alpha S1)
          Length = 538

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 76/325 (23%), Positives = 134/325 (40%), Gaps = 51/325 (15%)

Query: 261 IETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQEN 320
           +E L RK +C    ES   +  I S +   T N   + +AGA+P+ + LL+SE    QE 
Sbjct: 132 VEFLKRKENCTLQFESAWVLTNIASGNSLQTRN---VIQAGAVPIFIELLSSEFEDVQEQ 188

Query: 321 AVTSILN---------------------LSIYENNKGLIMLAGAI-------------PS 346
           AV ++ N                     L ++     L M   A+             P 
Sbjct: 189 AVWALGNIAGDSTMCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPE 248

Query: 347 IVQV----------LRAGTMEARENAAATLFSLSLADENKI-IIGASGAISALVDLLQNG 395
             +V          L     +   +A   L  LS    +KI  +  +G    LV+LL + 
Sbjct: 249 FAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHN 308

Query: 396 SPRGKKDAATALFNLCIYQGNKGRAI-RAGIITALLNMLTDSSKSMVDEAL-TIMSVLAS 453
             +    A  A+ N+      + + I     + +LL++L+   +S+  EA  TI ++ A 
Sbjct: 309 DYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAG 368

Query: 454 HQEAKVSIVKASTIPVLIDLLRTGLPRNKENAA-AILLALCKRDTDNLSCISRLGAVIPL 512
           ++    +++ A+  P LI +L+T   R ++ AA AI  A      + +  +  LG + PL
Sbjct: 369 NRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPL 428

Query: 513 SELARTGTERAKRKATSLLEHLRKL 537
            +L      +  + A + LE++ +L
Sbjct: 429 CDLLTVMDAKIVQVALNGLENILRL 453



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 45/182 (24%), Positives = 82/182 (44%), Gaps = 12/182 (6%)

Query: 286 LSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIML-AGAI 344
           LS    D    + +AG    LV LL   D      A+ ++ N+   ++ +  ++L   A+
Sbjct: 281 LSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSAL 340

Query: 345 PSIVQVLRAGTMEARENAAATLFSLSLADENKI--IIGASGAISALVDLLQNGSPRGKKD 402
            S++ +L +     ++ A  T+ +++  +  +I  +I A+    AL+ +LQ    R +K+
Sbjct: 341 QSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDAN-MFPALISILQTAEFRTRKE 399

Query: 403 AATALFNLCIYQGNKGRAIR----AGIITALLNMLTDSSKSMVDEALTIMS--VLASHQE 456
           AA A+ N     G     I+     G I  L ++LT     +V  AL  +   +    QE
Sbjct: 400 AAWAITNAT--SGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQE 457

Query: 457 AK 458
           AK
Sbjct: 458 AK 459


>PLAK_MOUSE (Q02257) Junction plakoglobin (Desmoplakin III)
           (Fragment)
          Length = 621

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 13/253 (5%)

Query: 232 NIEQPTGLTNG-----KIKKSDGSFRDVTGDIAAIETLVRKLSCRS-VEESRAAVAEIRS 285
           N E P  +T       ++ K + S R + G    +  +VR +   S ++ +R   + + +
Sbjct: 28  NDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHN 87

Query: 286 LSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAI 344
           LS    +  + I ++G IP LV +L+S        A+T++ NL +Y E  K  + LA  +
Sbjct: 88  LSHHR-EGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGL 146

Query: 345 PSIVQVLRAGTMEARENAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKD 402
             +V +L     +        L  L+  + E+K+II A+G    LV +++N S  +    
Sbjct: 147 QKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWT 206

Query: 403 AATALFNLCIYQGNKGRAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKV 459
            +  L  L +   NK   + AG + AL   LT +S  +V   L     +S +A+ QE   
Sbjct: 207 TSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLE 266

Query: 460 SIVKASTIPVLID 472
           S++K     + +D
Sbjct: 267 SVLKILVNQLSVD 279



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 66/304 (21%), Positives = 124/304 (40%), Gaps = 33/304 (10%)

Query: 257 DIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVM 316
           +   ++ L + L+  S    +  +  +R+LS  +T    L      + +LV+ L+ +DV 
Sbjct: 226 EAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGL---ESVLKILVNQLSVDDVN 282

Query: 317 TQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQ-VLRAGTME-ARENAAATLFSLSL-- 371
               A  ++ NL+   + NK L+     + +++  +LRAG  +   E A   L  L+   
Sbjct: 283 VLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRH 342

Query: 372 --ADENKIIIGASGAISALVDLLQNGSPRGKKDAATALF-NLCIYQGNKGRAIRAGIITA 428
             A+  +  +  +  I A+V LL   +      A   L  NL +   N      A +I  
Sbjct: 343 PEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPR 402

Query: 429 LLNMLTDSSKS---------------------MVDEALTIMSVLASHQEAKVSIVKASTI 467
           L+ +L  + +                      +V+     + +LA     ++ I + +TI
Sbjct: 403 LVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTI 462

Query: 468 PVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAKRKA 527
           P+ + LL + +   +  AA +L  L  +D +    I   GA  PL EL  +  E     A
Sbjct: 463 PLFVQLLYSSVENIQRVAAGVLCELA-QDKEAADAIDAEGASAPLMELLHSRNEGTATYA 521

Query: 528 TSLL 531
            ++L
Sbjct: 522 AAVL 525



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 46/180 (25%), Positives = 79/180 (43%), Gaps = 8/180 (4%)

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIM----LAGAIPSIVQVLRAGTME 357
           A+P L  LL  ED +    A   +  LS  E ++  +M    L  A+   +Q      ++
Sbjct: 19  ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQ--NTSDLD 76

Query: 358 ARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNK 417
                 + L +LS   E  + I  SG I ALV +L +        A T L NL +YQ   
Sbjct: 77  TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 136

Query: 418 GRAIR-AGIITALLNMLTDSSKSMVDEALTIMSVLA-SHQEAKVSIVKASTIPVLIDLLR 475
             A+R A  +  ++ +L  ++   +      + +LA  +QE+K+ I+       L+ ++R
Sbjct: 137 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMR 196


>ARM_DROME (P18824) Armadillo segment polarity protein
          Length = 843

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 75/298 (25%), Positives = 135/298 (45%), Gaps = 9/298 (3%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKLS-CRSVEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S   +      +  LVR +S    +E ++AAV  + +LS       + I ++G
Sbjct: 185 QLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHR-QGLLAIFKSG 243

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV LL+S        A+T++ NL ++++ +K  + LAG +  +V +L+   ++   
Sbjct: 244 GIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLA 303

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQN-GSPRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II ASG  + LV ++++    +     +  L  L +   NK 
Sbjct: 304 IVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKP 363

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGL 478
             + AG + AL   L + S  +V   L  +  L S    KV  ++A  +  L+ +L +  
Sbjct: 364 AIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNL-SDAATKVEGLEA-LLQSLVQVLGSTD 421

Query: 479 PRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAK--RKATSLLEHL 534
                 AA IL  L   +  N + + ++G V  L        +R +    A   L HL
Sbjct: 422 VNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRHL 479



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 2/139 (1%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLT-SEDVMTQ 318
           AI  L++ L+         A   +  LSK+      ++     +  LV  ++ S D+ + 
Sbjct: 160 AIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLEST 219

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSL-ADENKI 377
           + AV ++ NLS +      I  +G IP++V++L +        A  TL +L L  D +K+
Sbjct: 220 KAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKM 279

Query: 378 IIGASGAISALVDLLQNGS 396
            +  +G +  +V LLQ  +
Sbjct: 280 AVRLAGGLQKMVTLLQRNN 298



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 61/285 (21%), Positives = 114/285 (39%), Gaps = 22/285 (7%)

Query: 254 VTGDIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSE 313
           V G  A +++LV+ L    V     A   + +L+  +  N+  + + G +  LV  + + 
Sbjct: 403 VEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINA 462

Query: 314 DVMTQ--ENAVTSILNLSIYENNKGL----IMLAGAIPSIVQVLRAGTMEARENAAATLF 367
               +  E AV ++ +L+    +  L    + L   +  IV++L   +      A   L 
Sbjct: 463 GDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLI 522

Query: 368 -SLSLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAIRAGII 426
            +L+L   N   +   GAI  LV LL     R  +D      ++      +  A   G+ 
Sbjct: 523 RNLALCPANHAPLREHGAIHHLVRLLM----RAFQDTERQRSSIATTGSQQPSAYADGV- 577

Query: 427 TALLNMLTDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAA 486
                      + +V+  +  + +LA     +  I + S IP+ + LL   +   +  AA
Sbjct: 578 ---------RMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAA 628

Query: 487 AILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
            +L  L   D +    I + GA  PL++L  +  E     A ++L
Sbjct: 629 GVLCELA-ADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVL 672


>IMA2_ARATH (O04294) Importin alpha-2 subunit (Karyopherin alpha-2
           subunit) (KAP alpha)
          Length = 531

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 55/250 (22%), Positives = 115/250 (46%), Gaps = 5/250 (2%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLS-IYENNKGLIMLA 341
           + +++  +++N  +I E+GA+P+ + LL+S     +E AV ++ N++      + L++  
Sbjct: 143 LTNIASGTSENTNVIIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKCRDLVLSY 202

Query: 342 GAIPSIVQVLRAGT-MEARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSPRGK 400
           GA+  ++      T +    NA  TL +               A+  L  L+Q+      
Sbjct: 203 GAMTPLLSQFNENTKLSMLRNATWTLSNFCRGKPPPAFEQTQPALPVLERLVQSMDEEVL 262

Query: 401 KDAATALFNLCIYQGNKGRA-IRAGIITALLNMLTDSSKSMVDEAL-TIMSVLASHQEAK 458
            DA  AL  L     +K +A I AG++  L+ +L  SS S++  AL TI +++       
Sbjct: 263 TDACWALSYLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQT 322

Query: 459 VSIVKASTIPVLIDLLRTGLPRN-KENAAAILLALCKRDTDNLSCISRLGAVIPLSELAR 517
             ++    +P L++LL+    ++ K+ A   +  +   + D +  +   G +  L  + +
Sbjct: 323 QMVLDQQALPCLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQ 382

Query: 518 TGTERAKRKA 527
           +     K++A
Sbjct: 383 SAEFEVKKEA 392


>CTNB_RAT (Q9WU82) Beta-catenin
          Length = 781

 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 76/306 (24%), Positives = 131/306 (41%), Gaps = 15/306 (4%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKL-SCRSVEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S   +      +  +VR + +   VE +R     + +LS    +  + I ++G
Sbjct: 177 QLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR-EGLLAIFKSG 235

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV +L S        A+T++ NL ++ E  K  + LAG +  +V +L    ++   
Sbjct: 236 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLA 295

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II ASG   ALV++++  +  +     +  L  L +   NK 
Sbjct: 296 ITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKP 355

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKVSIVKASTIPVLIDLLR 475
             + AG + AL   LTD S+ +V   L     +S  A+ QE    +     +  L+ LL 
Sbjct: 356 AIVEAGGMQALGPHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL-----LGTLVQLLG 410

Query: 476 TGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPL--SELARTGTERAKRKATSLLEH 533
           +        AA IL  L   +  N   + ++G +  L  + L     E     A   L H
Sbjct: 411 SDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRH 470

Query: 534 LRKLQQ 539
           L    Q
Sbjct: 471 LTSRHQ 476



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 34/279 (12%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYE-NNKGLIMLA 341
           +R+LS  +T    +    G +  LV LL S+D+     A   + NL+     NK ++   
Sbjct: 385 LRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 342 GAIPSIVQ-VLRAGTME-ARENAAATLFSLSL----ADENKIIIGASGAISALVDLLQNG 395
           G I ++V+ VLRAG  E   E A   L  L+     A+  +  +     +  +V LL   
Sbjct: 442 GGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP 501

Query: 396 SPRGKKDAATALF-NLCIYQGNKGRAIRAGIITALLNMLTDSSKS--------------- 439
           S      A   L  NL +   N       G I  L+ +L  + +                
Sbjct: 502 SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFV 561

Query: 440 -------MVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLAL 492
                  +V+     + +LA     ++ I   +TIP+ + LL + +   +  AA +L  L
Sbjct: 562 EGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCEL 621

Query: 493 CKRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
             +D +    I   GA  PL+EL  +  E     A ++L
Sbjct: 622 A-QDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL 659



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 57/258 (22%), Positives = 103/258 (39%), Gaps = 6/258 (2%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLV-SLLTSEDVMTQ 318
           AI  L + L+         A   +  LSK+      ++     +  +V ++  + DV T 
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADEN-KI 377
                ++ NLS +      I  +G IP++V++L +        A  TL +L L  E  K+
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271

Query: 378 IIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAI--RAGIITALLN-MLT 434
            +  +G +  +V LL   + +      T    +  Y   + + I   +G   AL+N M T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLA-ITTDCLQILAYGNQESKLIILASGGPQALVNIMRT 330

Query: 435 DSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALCK 494
            + + ++     ++ VL+     K +IV+A  +  L   L     R  +N    L  L  
Sbjct: 331 YTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGPHLTDPSQRLVQNCLWTLRNLSD 390

Query: 495 RDTDNLSCISRLGAVIPL 512
             T        LG ++ L
Sbjct: 391 AATKQEGMEGLLGTLVQL 408



 Score = 30.8 bits (68), Expect = 9.3
 Identities = 24/82 (29%), Positives = 34/82 (41%)

Query: 289 RSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIMLAGAIPSIV 348
           R   NRI+I     IP+ V LL S     Q  A   +  L+  +     I   GA   + 
Sbjct: 582 RDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLT 641

Query: 349 QVLRAGTMEARENAAATLFSLS 370
           ++L +        AAA LF +S
Sbjct: 642 ELLHSRNEGVATYAAAVLFRMS 663


>PLAK_HUMAN (P14923) Junction plakoglobin (Desmoplakin III)
          Length = 743

 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 62/252 (24%), Positives = 113/252 (44%), Gaps = 12/252 (4%)

Query: 232 NIEQPTGLTNG-----KIKKSDGSFRDVTGDIAAIETLVRKLSCRS-VEESRAAVAEIRS 285
           N E P  +T       ++ K + S R + G    +  +VR +   S ++ +R   + + +
Sbjct: 151 NDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHN 210

Query: 286 LSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIMLAGAIP 345
           LS    +  + I ++G IP LV +L+S        A+T++ NL +Y+    +        
Sbjct: 211 LSHHR-EGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMACAGRRAQ 269

Query: 346 SIVQVLRAGTMEARENAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKDA 403
            +V +L     +        L  L+  + E+K+II A+G   ALV +++N S  +     
Sbjct: 270 KMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTT 329

Query: 404 ATALFNLCIYQGNKGRAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKVS 460
           +  L  L +   NK   + AG + AL   LT +S  +V   L     +S +A+ QE   S
Sbjct: 330 SRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLES 389

Query: 461 IVKASTIPVLID 472
           ++K     + +D
Sbjct: 390 VLKILVNQLSVD 401



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 66/304 (21%), Positives = 124/304 (40%), Gaps = 33/304 (10%)

Query: 257 DIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVM 316
           +   ++ L + L+  S    +  +  +R+LS  +T    L      + +LV+ L+ +DV 
Sbjct: 348 EAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGL---ESVLKILVNQLSVDDVN 404

Query: 317 TQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQ-VLRAGTME-ARENAAATLFSLSL-- 371
               A  ++ NL+   + NK L+     + +++  +LRAG  +   E A   L  L+   
Sbjct: 405 VLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRH 464

Query: 372 --ADENKIIIGASGAISALVDLLQNGSPRGKKDAATALF-NLCIYQGNKGRAIRAGIITA 428
             A+  +  +  +  I A+V LL   +      A   L  NL +   N      A +I  
Sbjct: 465 PEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPR 524

Query: 429 LLNMLTDSSKS---------------------MVDEALTIMSVLASHQEAKVSIVKASTI 467
           L+ +L  + +                      +V+     + +LA     ++ I + +TI
Sbjct: 525 LVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTI 584

Query: 468 PVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAKRKA 527
           P+ + LL + +   +  AA +L  L  +D +    I   GA  PL EL  +  E     A
Sbjct: 585 PLFVQLLYSSVENIQRVAAGVLCELA-QDKEAADAIDAEGASAPLMELLHSRNEGTATYA 643

Query: 528 TSLL 531
            ++L
Sbjct: 644 AAVL 647



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 47/181 (25%), Positives = 77/181 (41%), Gaps = 11/181 (6%)

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIM----LAGAIPSIVQVLRAGTME 357
           A+P L  LL  ED +    A   +  LS  E ++  +M    L  A+   +Q      ++
Sbjct: 142 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQ--NTSDLD 199

Query: 358 ARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNK 417
                 + L +LS   E  + I  SG I ALV +L +        A T L NL +YQ   
Sbjct: 200 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 259

Query: 418 GRAI---RAGIITALLNMLTDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLL 474
             A    RA  +  LLN       ++  + L +++    +QE+K+ I+       L+ ++
Sbjct: 260 KMACAGRRAQKMVPLLNKNNPKFLAITTDCLQLLAY--GNQESKLIILANGGPQALVQIM 317

Query: 475 R 475
           R
Sbjct: 318 R 318



 Score = 37.4 bits (85), Expect = 0.100
 Identities = 36/160 (22%), Positives = 75/160 (46%), Gaps = 4/160 (2%)

Query: 323 TSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADENK-IIIGA 381
           ++I++L  Y+++  L+    A+P + ++L          AA  +  LS  + ++  ++G+
Sbjct: 124 SAIVHLINYQDDAELV--TRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGS 181

Query: 382 SGAISALVDLLQNGSPRGKKDAATA-LFNLCIYQGNKGRAIRAGIITALLNMLTDSSKSM 440
              ++A+V  +QN S        T+ L NL  ++       ++G I AL+ ML+   +S+
Sbjct: 182 PQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESV 241

Query: 441 VDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPR 480
           +  A+T +  L  +QE             ++ LL    P+
Sbjct: 242 LFYAITTLHNLLLYQEGAKMACAGRRAQKMVPLLNKNNPK 281


>CTNB_MOUSE (Q02248) Beta-catenin
          Length = 781

 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 76/306 (24%), Positives = 131/306 (41%), Gaps = 15/306 (4%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKL-SCRSVEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S   +      +  +VR + +   VE +R     + +LS    +  + I ++G
Sbjct: 177 QLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR-EGLLAIFKSG 235

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV +L S        A+T++ NL ++ E  K  + LAG +  +V +L    ++   
Sbjct: 236 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLA 295

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II ASG   ALV++++  +  +     +  L  L +   NK 
Sbjct: 296 ITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKP 355

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKVSIVKASTIPVLIDLLR 475
             + AG + AL   LTD S+ +V   L     +S  A+ QE    +     +  L+ LL 
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL-----LGTLVQLLG 410

Query: 476 TGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPL--SELARTGTERAKRKATSLLEH 533
           +        AA IL  L   +  N   + ++G +  L  + L     E     A   L H
Sbjct: 411 SDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRH 470

Query: 534 LRKLQQ 539
           L    Q
Sbjct: 471 LTSRHQ 476



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 34/279 (12%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYE-NNKGLIMLA 341
           +R+LS  +T    +    G +  LV LL S+D+     A   + NL+     NK ++   
Sbjct: 385 LRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 342 GAIPSIVQ-VLRAGTME-ARENAAATLFSLSL----ADENKIIIGASGAISALVDLLQNG 395
           G I ++V+ VLRAG  E   E A   L  L+     A+  +  +     +  +V LL   
Sbjct: 442 GGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP 501

Query: 396 SPRGKKDAATALF-NLCIYQGNKGRAIRAGIITALLNMLTDSSKS--------------- 439
           S      A   L  NL +   N       G I  L+ +L  + +                
Sbjct: 502 SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFV 561

Query: 440 -------MVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLAL 492
                  +V+     + +LA     ++ I   +TIP+ + LL + +   +  AA +L  L
Sbjct: 562 EGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCEL 621

Query: 493 CKRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
             +D +    I   GA  PL+EL  +  E     A ++L
Sbjct: 622 A-QDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL 659



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 48/216 (22%), Positives = 91/216 (41%), Gaps = 6/216 (2%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLV-SLLTSEDVMTQ 318
           AI  L + L+         A   +  LSK+      ++     +  +V ++  + DV T 
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADEN-KI 377
                ++ NLS +      I  +G IP++V++L +        A  TL +L L  E  K+
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271

Query: 378 IIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAI--RAGIITALLN-MLT 434
            +  +G +  +V LL   + +      T    +  Y   + + I   +G   AL+N M T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLA-ITTDCLQILAYGNQESKLIILASGGPQALVNIMRT 330

Query: 435 DSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVL 470
            + + ++     ++ VL+     K +IV+A  +  L
Sbjct: 331 YTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366



 Score = 30.8 bits (68), Expect = 9.3
 Identities = 24/82 (29%), Positives = 34/82 (41%)

Query: 289 RSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIMLAGAIPSIV 348
           R   NRI+I     IP+ V LL S     Q  A   +  L+  +     I   GA   + 
Sbjct: 582 RDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLT 641

Query: 349 QVLRAGTMEARENAAATLFSLS 370
           ++L +        AAA LF +S
Sbjct: 642 ELLHSRNEGVATYAAAVLFRMS 663


>CTNB_HUMAN (P35222) Beta-catenin (PRO2286)
          Length = 781

 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 76/306 (24%), Positives = 131/306 (41%), Gaps = 15/306 (4%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKL-SCRSVEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S   +      +  +VR + +   VE +R     + +LS    +  + I ++G
Sbjct: 177 QLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR-EGLLAIFKSG 235

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV +L S        A+T++ NL ++ E  K  + LAG +  +V +L    ++   
Sbjct: 236 GIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLA 295

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQNGS-PRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II ASG   ALV++++  +  +     +  L  L +   NK 
Sbjct: 296 ITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKP 355

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKVSIVKASTIPVLIDLLR 475
             + AG + AL   LTD S+ +V   L     +S  A+ QE    +     +  L+ LL 
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGL-----LGTLVQLLG 410

Query: 476 TGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPL--SELARTGTERAKRKATSLLEH 533
           +        AA IL  L   +  N   + ++G +  L  + L     E     A   L H
Sbjct: 411 SDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRH 470

Query: 534 LRKLQQ 539
           L    Q
Sbjct: 471 LTSRHQ 476



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 34/279 (12%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYE-NNKGLIMLA 341
           +R+LS  +T    +    G +  LV LL S+D+     A   + NL+     NK ++   
Sbjct: 385 LRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 342 GAIPSIVQ-VLRAGTME-ARENAAATLFSLSL----ADENKIIIGASGAISALVDLLQNG 395
           G I ++V+ VLRAG  E   E A   L  L+     A+  +  +     +  +V LL   
Sbjct: 442 GGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPP 501

Query: 396 SPRGKKDAATALF-NLCIYQGNKGRAIRAGIITALLNMLTDSSKS--------------- 439
           S      A   L  NL +   N       G I  L+ +L  + +                
Sbjct: 502 SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFV 561

Query: 440 -------MVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLAL 492
                  +V+     + +LA     ++ I   +TIP+ + LL + +   +  AA +L  L
Sbjct: 562 EGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCEL 621

Query: 493 CKRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
             +D +    I   GA  PL+EL  +  E     A ++L
Sbjct: 622 A-QDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL 659



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 48/216 (22%), Positives = 91/216 (41%), Gaps = 6/216 (2%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLV-SLLTSEDVMTQ 318
           AI  L + L+         A   +  LSK+      ++     +  +V ++  + DV T 
Sbjct: 152 AIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETA 211

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADEN-KI 377
                ++ NLS +      I  +G IP++V++L +        A  TL +L L  E  K+
Sbjct: 212 RCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKM 271

Query: 378 IIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAI--RAGIITALLN-MLT 434
            +  +G +  +V LL   + +      T    +  Y   + + I   +G   AL+N M T
Sbjct: 272 AVRLAGGLQKMVALLNKTNVKFLA-ITTDCLQILAYGNQESKLIILASGGPQALVNIMRT 330

Query: 435 DSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVL 470
            + + ++     ++ VL+     K +IV+A  +  L
Sbjct: 331 YTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366



 Score = 30.8 bits (68), Expect = 9.3
 Identities = 24/82 (29%), Positives = 34/82 (41%)

Query: 289 RSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIMLAGAIPSIV 348
           R   NRI+I     IP+ V LL S     Q  A   +  L+  +     I   GA   + 
Sbjct: 582 RDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLT 641

Query: 349 QVLRAGTMEARENAAATLFSLS 370
           ++L +        AAA LF +S
Sbjct: 642 ELLHSRNEGVATYAAAVLFRMS 663


>IMA1_YEAST (Q02821) Importin alpha subunit (Karyopherin alpha
           subunit) (Serine-rich RNA polymerase I suppressor
           protein)
          Length = 542

 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 71/314 (22%), Positives = 133/314 (41%), Gaps = 13/314 (4%)

Query: 233 IEQPTGLTNGKIKKSDGSFRDVTGDIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTD 292
           +E    LTN  I     +   V  D  A+   ++ L   SVE    A+  + +++  STD
Sbjct: 149 LEAAWALTN--IASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTD 206

Query: 293 NRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQVL 351
            R  + +  A+  ++ L  S        A  ++ NL   +       +++ A+P++ +++
Sbjct: 207 YRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLI 266

Query: 352 RAGTMEARENAAATLFSLSLADENKIIIGASGAI-SALVDLLQNGSPRGKKDAATALFNL 410
            +   E   +A   +  LS   +  I       I   LV+LL + S   +  A  A+ N 
Sbjct: 267 YSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGN- 325

Query: 411 CIYQGNKGR---AIRAGIITALLNMLTDSSKSMVDEAL-TIMSVLASHQEAKVSIVKAST 466
            I  GN  +    I AG++ AL  +L+   +++  EA  TI ++ A + E   +++ A+ 
Sbjct: 326 -IVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANL 384

Query: 467 IPVLIDLLRTGLPRNKENAAAILLALCK---RDTDNLSCISRLGAVIPLSELARTGTERA 523
           IP L+ LL     + K+ A   +        +  D +  +   G + PL +L      R 
Sbjct: 385 IPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRI 444

Query: 524 KRKATSLLEHLRKL 537
                  LE++ K+
Sbjct: 445 IEVTLDALENILKM 458



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 32/116 (27%), Positives = 54/116 (45%), Gaps = 2/116 (1%)

Query: 421 IRAGIITALLNMLTDSSKSMVD-EALTIMSVLASHQEAKVSIV-KASTIPVLIDLLRTGL 478
           I+AG++  L+  + ++   M+  EA   ++ +AS   A+  +V  A  +P+ I LL TG 
Sbjct: 127 IQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGS 186

Query: 479 PRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLLEHL 534
              KE A   L  +    TD    + +  A+ P+  L  +      R AT  L +L
Sbjct: 187 VEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNL 242


>IMA1_SCHPO (O14063) Importin alpha subunit (Karyopherin alpha
           subunit) (Serine-rich RNA polymerase I suppressor
           protein)
          Length = 542

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 90/392 (22%), Positives = 161/392 (40%), Gaps = 54/392 (13%)

Query: 201 TCPKTQQKLQHLTLTPNY--VLRSLVSQWCIEHNIEQPTGLTNGKIKKSDGSFRDVTGDI 258
           T P  Q K   L L      +L++L S   IE  I+          K+++   + V  D 
Sbjct: 63  TIPLEQDKENDLELELQLPDLLKALYSD-DIEAQIQATAKFRKALSKETNPPIQKVI-DA 120

Query: 259 AAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQ 318
             +   V  LS  +      A   + +++  S++   ++ EA A+PV VSLL+S +   +
Sbjct: 121 GVVPRFVEFLSHENNLLKFEASWALTNVASGSSNQTHVVVEANAVPVFVSLLSSSEQDVR 180

Query: 319 ENAVTSILN---------------------LSIYENNKGLIMLAGAIPSIVQVLRAGTME 357
           E AV ++ N                     L+I E+N+ L ML  +  ++  + R    +
Sbjct: 181 EQAVWALGNIAGDSPMCRDHVLQCGVLEPLLNIIESNRRLSMLRNSTWTLSNMCRGKNPQ 240

Query: 358 ARENAAA----TLFSLSLADENKIIIGASGAIS--------------------ALVDLLQ 393
              N+ +     L  L    +  +++ A  AIS                     LV+LL 
Sbjct: 241 PDWNSISQVIPVLSKLIYTLDEDVLVDALWAISYLSDGANEKIQAIIDAGIPRRLVELLM 300

Query: 394 NGSPRGKKDAATALFNLCIYQGNKGRA-IRAGIITALLNMLTDSSKSMVDEAL-TIMSVL 451
           + S + +  A  ++ N+      + +  I  G ++ALL++L+     +  EA  TI ++ 
Sbjct: 301 HPSAQVQTPALRSVGNIVTGDDVQTQVIINCGALSALLSLLSSPRDGVRKEACWTISNIT 360

Query: 452 ASHQEAKVSIVKASTIPVLIDLLRTG-LPRNKENAAAILLALC--KRDTDNLSCISRLGA 508
           A +      +++A+ IP LI LL T      KE   AI  A     R  D +  +   GA
Sbjct: 361 AGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAISNATSGGARRPDQIRYLVEQGA 420

Query: 509 VIPLSELARTGTERAKRKATSLLEHLRKLQQL 540
           + PL  L      +  + A   +E++ ++ +L
Sbjct: 421 IKPLCNLLACQDNKIIQVALDGIENILRVGEL 452


>PLAK_XENLA (P30998) Junction plakoglobin (Desmoplakin III)
          Length = 738

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 55/228 (24%), Positives = 105/228 (45%), Gaps = 8/228 (3%)

Query: 243 KIKKSDGSFRDVTGDIAAIETLVRKLSCRS-VEESRAAVAEIRSLSKRSTDNRILIAEAG 301
           ++ K + S + +      +  +VR +   S ++ +R   + + +LS    +  + I ++G
Sbjct: 164 QLSKKEASRKALMQSPQIVAAIVRTMQHTSDMDTARCTTSILHNLSHHR-EGLLSIFKSG 222

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIY-ENNKGLIMLAGAIPSIVQVLRAGTMEARE 360
            IP LV +L+S        A+T++ NL +Y E  K  + LA  +  +V +L     +   
Sbjct: 223 GIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLA 282

Query: 361 NAAATLFSLSLAD-ENKIIIGASGAISALVDLLQN-GSPRGKKDAATALFNLCIYQGNKG 418
                L  L+  + E+K+II  +G    LV +++N    +     +  L  L +   NK 
Sbjct: 283 ITTDCLQLLAYGNQESKLIILGNGGPQGLVQIMRNYNYEKLLWTTSRVLKVLSVCPSNKP 342

Query: 419 RAIRAGIITALLNMLTDSSKSMVDEALTI---MSVLASHQEAKVSIVK 463
             + AG + AL   LT +S  +V   L     +S +A+ QE   +++K
Sbjct: 343 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLDNVLK 390



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 49/178 (27%), Positives = 81/178 (44%), Gaps = 4/178 (2%)

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYE-NNKGLIMLAGAIPSIVQVLR-AGTMEAR 359
           AIP L  LL  ED M    A   +  LS  E + K L+     + +IV+ ++    M+  
Sbjct: 139 AIPELTKLLNDEDPMVVNKASMIVNQLSKKEASRKALMQSPQIVAAIVRTMQHTSDMDTA 198

Query: 360 ENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGR 419
               + L +LS   E  + I  SG I ALV +L +        A T L NL +YQ     
Sbjct: 199 RCTTSILHNLSHHREGLLSIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 258

Query: 420 AIR-AGIITALLNMLTDSSKSMVDEALTIMSVLA-SHQEAKVSIVKASTIPVLIDLLR 475
           A+R A  +  ++ +L  ++   +      + +LA  +QE+K+ I+       L+ ++R
Sbjct: 259 AVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILGNGGPQGLVQIMR 316



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 54/233 (23%), Positives = 92/233 (39%), Gaps = 12/233 (5%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQE 319
           AI  L + L+         A   +  LSK+    + L+     +  +V  +     M   
Sbjct: 139 AIPELTKLLNDEDPMVVNKASMIVNQLSKKEASRKALMQSPQIVAAIVRTMQHTSDMDTA 198

Query: 320 NAVTSIL-NLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADEN-KI 377
              TSIL NLS +      I  +G IP++V++L +        A  TL +L L  E  K+
Sbjct: 199 RCTTSILHNLSHHREGLLSIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 258

Query: 378 IIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAI------RAGIITALLN 431
            +  +  +  +V LL   +P+      T    L  Y   + + I        G++  + N
Sbjct: 259 AVRLADGLQKMVPLLNKNNPKFLA-ITTDCLQLLAYGNQESKLIILGNGGPQGLVQIMRN 317

Query: 432 MLTDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKEN 484
              +         L ++SV  S+   K +IV+A  +  L   L +  PR  +N
Sbjct: 318 YNYEKLLWTTSRVLKVLSVCPSN---KPAIVEAGGMQALGKHLTSNSPRLVQN 367



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 67/304 (22%), Positives = 123/304 (40%), Gaps = 33/304 (10%)

Query: 257 DIAAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVM 316
           +   ++ L + L+  S    +  +  +R+LS  +T    L      + +LV+ L+S+DV 
Sbjct: 346 EAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGL---DNVLKILVNQLSSDDVN 402

Query: 317 TQENAVTSILNLSIYEN-NKGLIMLAGAIPSIVQ-VLRAGTME-ARENAAATLFSLSLAD 373
               A  ++ NL+     NK L+  +  + S++  +LRA   +   E A   +  L+   
Sbjct: 403 VLTCATGTLSNLTCNNGRNKTLVTQSNGVESLIHTILRASDKDDIAEPAVCAMRHLTSRH 462

Query: 374 ENKIIIGASG----AISALVDLLQNGSPRGKKDAATALF-NLCIYQGNKGRAIRAGIITA 428
           ++  +   S      I A+V LL          A   L  NL +   N      AG+I  
Sbjct: 463 QDAEVAQNSVRLHYGIPAIVKLLNPPYQWPLVKATIGLIRNLALCPANHAPLYDAGVIPR 522

Query: 429 LLNMLTDSSKS---------------------MVDEALTIMSVLASHQEAKVSIVKASTI 467
           L+ +L  S +                      +V+     + +LA     ++ I K +TI
Sbjct: 523 LVQLLVKSHQDAQRHAASGTQQPYTDGVKMEEIVEGCTGALHILARDPVNRMDIYKLNTI 582

Query: 468 PVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELARTGTERAKRKA 527
           P+ + LL + +   +  ++ +L  L  +D +    I   GA  PL EL  +  E     A
Sbjct: 583 PLFVQLLYSPVENIQRVSSGVLCELA-QDKEAADTIDAEGASAPLMELLHSRNEGIATYA 641

Query: 528 TSLL 531
            ++L
Sbjct: 642 AAVL 645



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 37/153 (24%), Positives = 68/153 (44%), Gaps = 7/153 (4%)

Query: 219 VLRSLVSQWCIEH-NIEQPTGLTNGKIKKSDGSFRDVTGDIAAIETLVRKLSCRSVEESR 277
           VL+ LV+Q   +  N+      T   +  ++G  + +      +E+L+  +   S ++  
Sbjct: 388 VLKILVNQLSSDDVNVLTCATGTLSNLTCNNGRNKTLVTQSNGVESLIHTILRASDKDDI 447

Query: 278 A--AVAEIRSLSKRSTDNRIL---IAEAGAIPVLVSLLTSEDVMTQENAVTSIL-NLSIY 331
           A  AV  +R L+ R  D  +    +     IP +V LL          A   ++ NL++ 
Sbjct: 448 AEPAVCAMRHLTSRHQDAEVAQNSVRLHYGIPAIVKLLNPPYQWPLVKATIGLIRNLALC 507

Query: 332 ENNKGLIMLAGAIPSIVQVLRAGTMEARENAAA 364
             N   +  AG IP +VQ+L     +A+ +AA+
Sbjct: 508 PANHAPLYDAGVIPRLVQLLVKSHQDAQRHAAS 540


>IMA_DROME (P52295) Importin alpha subunit (Karyopherin alpha
           subunit) (Pendulin)
          Length = 522

 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 60/244 (24%), Positives = 114/244 (46%), Gaps = 16/244 (6%)

Query: 303 IPVLVSLLTSEDVMTQENAVTSILNLSIYENNK-GLIMLAGAIPSIVQVLRAGTMEAREN 361
           +PVL  LL S+D+    +A  ++  ++  +N K   ++ + A+P +V++L+         
Sbjct: 242 LPVLSQLLLSQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVP 301

Query: 362 AAATLFSL-SLADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGR- 419
           A  ++ ++ +  D+   ++ ASG +  L  LLQ+      K+AA  + N  I  GN+ + 
Sbjct: 302 ALRSVGNIVTGTDQQTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSN--ITAGNQKQI 359

Query: 420 --AIRAGIITALLNMLTDSS-KSMVDEALTIMSVLASHQEAKV--SIVKASTIPVLIDLL 474
              I+AGI   L  +L     K+  + A  + +   S    ++   I K   +   IDLL
Sbjct: 360 QAVIQAGIFQQLRTVLEKGDFKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLL 419

Query: 475 RTGLPRN---KENAAAILLALCKR--DTDNLS-CISRLGAVIPLSELARTGTERAKRKAT 528
            T  PR     +   + L AL ++   T+NL   +  +G +  L  L +   E   +KA 
Sbjct: 420 DTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVEEMGGLDKLETLQQHENEEVYKKAY 479

Query: 529 SLLE 532
           ++++
Sbjct: 480 AIID 483


>IMA2_XENLA (P52171) Importin alpha-2 subunit (Karyopherin alpha-2
           subunit)
          Length = 522

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 51/256 (19%), Positives = 114/256 (43%), Gaps = 17/256 (6%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLS----IYENNKGLI 338
           + +++  ++D    + + GAIP  +SL++S  +   E AV ++ N++    +Y   +  +
Sbjct: 140 LTNIASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLY---RDAL 196

Query: 339 MLAGAIPSIVQVLRAGT-MEARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSP 397
           +    IP ++ ++   T +    N   TL +L     NK       A+  ++ +L     
Sbjct: 197 ISCNVIPPLLTLVNPQTPLGYLRNITWTLSNLC---RNKNPYPPMSAVLQILPVLTQLML 253

Query: 398 RGKKD--AATALFNLCIYQGNKGR---AIRAGIITALLNMLTDSSKSMVDEAL-TIMSVL 451
              KD  + T      +  G+  R    ++ G++  L+ ++     S++  +L T+ +++
Sbjct: 254 HEDKDILSDTCWAMSYLTDGSNDRIDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNIV 313

Query: 452 ASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIP 511
               +   + + A  + VL  LLR   P  ++ AA  L  +       +  +   G + P
Sbjct: 314 TGTDKQTQAAIDAGVLSVLPQLLRHQKPSIQKEAAWALSNIAAGPAPQIQQMITCGLLSP 373

Query: 512 LSELARTGTERAKRKA 527
           L +L + G  +A+++A
Sbjct: 374 LVDLLKKGDFKAQKEA 389



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 38/170 (22%), Positives = 82/170 (47%), Gaps = 10/170 (5%)

Query: 286 LSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIML-AGAI 344
           L+  S D   ++ + G +  L+ L+ S ++     ++ ++ N+    + +    + AG +
Sbjct: 270 LTDGSNDRIDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNIVTGTDKQTQAAIDAGVL 329

Query: 345 PSIVQVLRAGTMEARENAAATLFSLSLADENKII-IGASGAISALVDLLQNGSPRGKKDA 403
             + Q+LR      ++ AA  L +++     +I  +   G +S LVDLL+ G  + +K+A
Sbjct: 330 SVLPQLLRHQKPSIQKEAAWALSNIAAGPAPQIQQMITCGLLSPLVDLLKKGDFKAQKEA 389

Query: 404 ATALFNLCI--YQGNKGRAIRAGIITALLNMLTDSSKSMVDEALTIMSVL 451
             A+ N           + ++ G++  LLN+LT      + ++ TI+ +L
Sbjct: 390 VWAVTNYTSGGTVEQVVQLVQCGVLEPLLNLLT------IKDSKTILVIL 433


>CTNB_TRIGR (P35223) Beta-catenin
          Length = 820

 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 51/220 (23%), Positives = 99/220 (44%), Gaps = 9/220 (4%)

Query: 302 AIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEAREN 361
           A P  V  L+    M +     +++NL  Y+++  L     AIP + ++L    +     
Sbjct: 133 AHPTAVQRLSEPSQMLKH----AVVNLINYQDDADLA--TRAIPELTKLLNDDDLVVVNQ 186

Query: 362 AAATLFSLSLADENK-IIIGASGAISALVDLLQNGSP-RGKKDAATALFNLCIYQGNKGR 419
           AA  +  LS  + ++  I+ +   ++ALV  + N +     + AA  L NL  ++    +
Sbjct: 187 AAMMVHQLSKKEASRHAIMNSPQMVAALVRAMSNSNDAETTRCAAGTLHNLSHHRAGLLQ 246

Query: 420 AIRAGIITALLNMLTDSSKSMVDEALTIMSVLASHQE-AKVSIVKASTIPVLIDLLRTGL 478
             ++G I AL+ +L+   +S++  A+T +  L  HQE +K+++  A  +  ++ LL    
Sbjct: 247 IFKSGGIPALIKLLSSPVESVLFYAITTLHNLLLHQEGSKMAVRLAGGLQKMVALLSRNN 306

Query: 479 PRNKENAAAILLALCKRDTDNLSCISRLGAVIPLSELART 518
           P+        L  L   + ++   I   G    L  + RT
Sbjct: 307 PKFLAITTDCLQILAYGNQESKLIILASGGPAALVHIMRT 346



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 58/248 (23%), Positives = 106/248 (42%), Gaps = 8/248 (3%)

Query: 260 AIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLT-SEDVMTQ 318
           AI  L + L+   +     A   +  LSK+      ++     +  LV  ++ S D  T 
Sbjct: 168 AIPELTKLLNDDDLVVVNQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAMSNSNDAETT 227

Query: 319 ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSLADE-NKI 377
             A  ++ NLS +      I  +G IP+++++L +        A  TL +L L  E +K+
Sbjct: 228 RCAAGTLHNLSHHRAGLLQIFKSGGIPALIKLLSSPVESVLFYAITTLHNLLLHQEGSKM 287

Query: 378 IIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAI--RAGIITALLN-MLT 434
            +  +G +  +V LL   +P+      T    +  Y   + + I   +G   AL++ M T
Sbjct: 288 AVRLAGGLQKMVALLSRNNPKFLA-ITTDCLQILAYGNQESKLIILASGGPAALVHIMRT 346

Query: 435 DSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAIL--LAL 492
              + ++     ++ VL+     K +IV+A  +  L   L     R  +N    L  L+ 
Sbjct: 347 YDYEKLLWTTSRVLKVLSVCHNNKPAIVEAGGMSALGLHLGHHSNRLVQNCLWTLRNLSD 406

Query: 493 CKRDTDNL 500
           C R TD++
Sbjct: 407 CHRGTDDI 414



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 55/278 (19%), Positives = 113/278 (39%), Gaps = 24/278 (8%)

Query: 261 IETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQ-- 318
           ++ LV+ L+   +     A   + +L+  ++ N++++++   +  LV  L       +  
Sbjct: 418 LQMLVQLLASNDINVVTCACGILSNLTCNNSRNKMIVSQMAGVEALVQTLMKAGDREEIT 477

Query: 319 ENAVTSILNLSIY----ENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLF-SLSLAD 373
           E AV ++ +++      E  +  + L   IP IV++L   +      A   L  +L+L  
Sbjct: 478 EPAVCALRHVTSRHPGAEMGQNTVRLNYGIPVIVKLLHPPSRWPLIKATVGLIRNLALCS 537

Query: 374 ENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNLCIYQGNKGRAIRAGIITALLNML 433
            N   +   GA+  LV LL       ++ ++          G++G     G+        
Sbjct: 538 ANHAPLREQGALHRLVQLLMRAHQDTQRRSSMGS------TGSQGGNYADGV-------- 583

Query: 434 TDSSKSMVDEALTIMSVLASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALC 493
               + +V+     + +LA     +  I   + IP+ + LL   +  N +  AA +L+  
Sbjct: 584 --RMEDIVEGTTGALHILARDSHNRALIQGLNCIPLFVQLLYNNI-ENIQRVAAGVLSEL 640

Query: 494 KRDTDNLSCISRLGAVIPLSELARTGTERAKRKATSLL 531
             +      I + GA  PL+EL  +  E     A ++L
Sbjct: 641 SLEKQGAEMIEQEGATAPLTELLHSRNEGVATYAAAVL 678



 Score = 34.3 bits (77), Expect = 0.84
 Identities = 41/159 (25%), Positives = 61/159 (37%), Gaps = 26/159 (16%)

Query: 277 RAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQ------------------ 318
           +A V  IR+L+  S  N   + E GA+  LV LL      TQ                  
Sbjct: 524 KATVGLIRNLALCSA-NHAPLREQGALHRLVQLLMRAHQDTQRRSSMGSTGSQGGNYADG 582

Query: 319 -------ENAVTSILNLSIYENNKGLIMLAGAIPSIVQVLRAGTMEARENAAATLFSLSL 371
                  E    ++  L+   +N+ LI     IP  VQ+L       +  AA  L  LSL
Sbjct: 583 VRMEDIVEGTTGALHILARDSHNRALIQGLNCIPLFVQLLYNNIENIQRVAAGVLSELSL 642

Query: 372 ADENKIIIGASGAISALVDLLQNGSPRGKKDAATALFNL 410
             +   +I   GA + L +LL + +      AA  L+ +
Sbjct: 643 EKQGAEMIEQEGATAPLTELLHSRNEGVATYAAAVLYRM 681


>IMA_LYCES (O22478) Importin alpha subunit (Karyopherin alpha
           subunit) (KAP alpha)
          Length = 527

 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 43/154 (27%), Positives = 75/154 (47%), Gaps = 3/154 (1%)

Query: 259 AAIETLVRKLSCRSVEESRAAVAEIRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQ 318
           AA+ TL R +     E    A   +  LS  + D    + EAG    LV LL        
Sbjct: 243 AALPTLGRLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCSRLVELLLHSSPSVL 302

Query: 319 ENAVTSILNLSIYENNKGLIMLAG-AIPSIVQVLRAGTMEA-RENAAATLFSLSLADENK 376
             A+ ++ N+   ++ +  +M+   A+P +V +L     ++ ++ A  T+ +++  + N+
Sbjct: 303 IPALRTVGNIVTGDDIQTQVMIDHHALPCLVNLLTQNYKKSIKKEACWTISNITAGNRNQ 362

Query: 377 I-IIGASGAISALVDLLQNGSPRGKKDAATALFN 409
           I I+  +G I+ LV LLQN     KK+AA A+ N
Sbjct: 363 IQIVIEAGIIAPLVYLLQNAEFEIKKEAAWAISN 396


>IMA1_XENLA (P52170) Importin alpha-1 subunit (Karyopherin alpha-1
           subunit)
          Length = 521

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 51/256 (19%), Positives = 112/256 (42%), Gaps = 17/256 (6%)

Query: 283 IRSLSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLS----IYENNKGLI 338
           + +++  ++D    + + GAIP  +SL++S  +   E AV ++ N++    +Y   +  +
Sbjct: 140 LTNIASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLY---RDAL 196

Query: 339 MLAGAIPSIVQVLRAGT-MEARENAAATLFSLSLADENKIIIGASGAISALVDLLQNGSP 397
           +    IP ++ ++   T +    N    L +L     NK       A+  ++ +L     
Sbjct: 197 INCNVIPPLLALVNPQTPLGYLRNITWMLSNLC---RNKNPYPPMSAVLQILPVLTQLMH 253

Query: 398 RGKKD--AATALFNLCIYQGNKGR---AIRAGIITALLNMLTDSSKSMVDEAL-TIMSVL 451
              KD  + T      +  G+  R    ++ GI+  L+ ++     S+V  +L T+ +++
Sbjct: 254 HDDKDILSDTCWAMSYLTDGSNDRIDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNIV 313

Query: 452 ASHQEAKVSIVKASTIPVLIDLLRTGLPRNKENAAAILLALCKRDTDNLSCISRLGAVIP 511
               +   + + A  + VL  LLR   P  ++ AA  +  +       +  +   G + P
Sbjct: 314 TGTDKQTQAAIDAGVLSVLPQLLRHQKPSIQKEAAWAISNIAAGPAPQIQQMITCGLLSP 373

Query: 512 LSELARTGTERAKRKA 527
           L +L   G  +A+++A
Sbjct: 374 LVDLLNKGDFKAQKEA 389



 Score = 38.5 bits (88), Expect = 0.045
 Identities = 37/170 (21%), Positives = 81/170 (46%), Gaps = 10/170 (5%)

Query: 286 LSKRSTDNRILIAEAGAIPVLVSLLTSEDVMTQENAVTSILNLSIYENNKGLIML-AGAI 344
           L+  S D   ++ + G +  L+ L+ S ++     ++ ++ N+    + +    + AG +
Sbjct: 270 LTDGSNDRIDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNIVTGTDKQTQAAIDAGVL 329

Query: 345 PSIVQVLRAGTMEARENAAATLFSLSLADENKII-IGASGAISALVDLLQNGSPRGKKDA 403
             + Q+LR      ++ AA  + +++     +I  +   G +S LVDLL  G  + +K+A
Sbjct: 330 SVLPQLLRHQKPSIQKEAAWAISNIAAGPAPQIQQMITCGLLSPLVDLLNKGDFKAQKEA 389

Query: 404 ATALFNLCI--YQGNKGRAIRAGIITALLNMLTDSSKSMVDEALTIMSVL 451
             A+ N           + ++ G++  LLN+LT      + ++ TI+ +L
Sbjct: 390 VWAVTNYTSGGTVEQVVQLVQCGVLEPLLNLLT------IKDSKTILVIL 433


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.315    0.131    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,224,378
Number of Sequences: 164201
Number of extensions: 2293511
Number of successful extensions: 7168
Number of sequences better than 10.0: 105
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 6937
Number of HSP's gapped (non-prelim): 207
length of query: 540
length of database: 59,974,054
effective HSP length: 115
effective length of query: 425
effective length of database: 41,090,939
effective search space: 17463649075
effective search space used: 17463649075
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)