BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC148395.15 - phase: 0
(730 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MRP2_HUMAN (Q92887) Canalicular multispecific organic anion tran... 466 e-131
MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1 (A... 459 e-129
MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion tran... 458 e-128
MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4 (M... 457 e-128
MRP2_RABIT (Q28689) Canalicular multispecific organic anion tran... 457 e-128
MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5 456 e-127
MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1 (A... 454 e-127
MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (A... 452 e-126
MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5 (M... 451 e-126
MRP2_RAT (Q63120) Canalicular multispecific organic anion transp... 447 e-125
MRP3_HUMAN (O15438) Canalicular multispecific organic anion tran... 446 e-124
MRP3_RAT (O88563) Canalicular multispecific organic anion transp... 440 e-123
YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium... 432 e-120
YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c 423 e-118
BPT1_YEAST (P14772) Bile pigment transporter 1 401 e-111
ACC9_MOUSE (P70170) Sulfonylurea receptor 2 396 e-109
ACC9_RAT (Q63563) Sulfonylurea receptor 2 395 e-109
ACC8_RAT (Q09429) Sulfonylurea receptor 1 393 e-108
ACC8_HUMAN (Q09428) Sulfonylurea receptor 1 391 e-108
ACC9_RABIT (P82451) Sulfonylurea receptor 2 390 e-108
>MRP2_HUMAN (Q92887) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2) (Multidrug resistance-associated protein 2)
(Canalicular multidrug resistance protein)
Length = 1545
Score = 466 bits (1200), Expect = e-131
Identities = 284/776 (36%), Positives = 423/776 (53%), Gaps = 66/776 (8%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMT--ALRDKTVILVTH 58
+SGGQKQRI LARA Y + DIYLLDDP SAVDAH +FN + L+ KT +LVTH
Sbjct: 761 LSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTH 820
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSA--------HKVTINDLNQN 107
+ FL +VD I+ +G +++ GSY LL F + + T++D ++
Sbjct: 821 SMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEE 880
Query: 108 --------SEVLSNPQDSHGFYLTK-----------NQSEGE-ISSIQGSIGAQ----LT 143
S V P+D+ + + ++S G + S++ S+ + L
Sbjct: 881 EDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLK 940
Query: 144 QEEEKVIGN---------VGWKPLWDYINYSN--GTLMSCLVILGQCCFLALQTSSNFWL 192
++EE V G G Y+ Y G +IL SN WL
Sbjct: 941 EDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWL 1000
Query: 193 ATAIEIPKVTDTT---------LIGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSF 243
+ K+ ++T +GVY L ++ FV++ +++A + AS
Sbjct: 1001 SAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQL 1060
Query: 244 TTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVT 296
+I APM FFD+TP + D+S +D +P SL + ++ + +I T
Sbjct: 1061 LNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMAT 1120
Query: 297 WQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVD 356
I+ +P + + +Q +Y +T+R+L R++ T++P+ + +ET G+ +RAF
Sbjct: 1121 PVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQ 1180
Query: 357 RFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVG 416
RF K+ +DT+ F + WL +R+E + NLTV +AL++++ LS VG
Sbjct: 1181 RFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDT-LSGDTVG 1239
Query: 417 LSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKG 476
LS AL + + R S + I++VERI ++ + E P + D RPP WPSKG
Sbjct: 1240 FVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDK-RPPPDWPSKG 1298
Query: 477 KIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDI 536
KI +VRYRP LVL+GITC ++GVVGRTG+GKS+L + LFR++E + G I
Sbjct: 1299 KIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358
Query: 537 LIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKET 596
+IDG++I S+GL DLR KL+IIPQ+P LF GS+R NLDP YSD+EIWKA+E LK
Sbjct: 1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSF 1418
Query: 597 ISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRI 656
++ L L V++ GGN S+GQRQL CLGR LL++++ILVLDEATA++D TD ++Q
Sbjct: 1419 VASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTT 1478
Query: 657 IRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 712
I+ EF CTVIT+AHR+ T++DSD VMVL GK++E P +L+ F + E
Sbjct: 1479 IQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKE 1534
Score = 68.9 bits (167), Expect = 4e-11
Identities = 54/217 (24%), Positives = 98/217 (44%), Gaps = 16/217 (7%)
Query: 495 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 554
++ + G V V+G GSGKS+LISA+ +E G I I G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 555 LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGN 614
+ +PQ+ + G+I+ N+ +++ + +E C L + LP + + ++G N
Sbjct: 702 -AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGIN 760
Query: 615 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAH 671
S GQ+Q L R + I +LD+ +++D+ I +++ + T + V H
Sbjct: 761 LSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTH 820
Query: 672 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSK 708
+ + D ++VL G +VE S L+ F+K
Sbjct: 821 SMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
>MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1531
Score = 459 bits (1182), Expect = e-129
Identities = 283/762 (37%), Positives = 413/762 (54%), Gaps = 52/762 (6%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCV--MTALRDKTVILVTH 58
+SGGQKQR+ LARAVY++ADIYL DDP SAVDAH +F + + L++KT ILVTH
Sbjct: 768 LSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTH 827
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTIN--DLNQNSEV-LS 112
+ +L +VD I+ GK+ + GSY+ LL AF + + T D +N +S
Sbjct: 828 SMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVS 887
Query: 113 NP-------------QDSHGFYLTKNQSE-----GEISSIQGSIGA------------QL 142
P DS G L + S G+IS S +L
Sbjct: 888 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 947
Query: 143 TQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVT 202
+ ++ G V WDY+ + G +S L I C +SN+WL+ + P V
Sbjct: 948 MEADKAQTGQVKLSVYWDYMK-AIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVN 1006
Query: 203 DT-----TLIGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDS 257
T + VY L IS V+ S ++ G+ AS SI +PM FF+
Sbjct: 1007 GTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFER 1066
Query: 258 TPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVAL 310
TP+ S +L +D IP + V+ VI T I+ P +
Sbjct: 1067 TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIY 1126
Query: 311 IFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDA 370
F+Q++Y A++R+L R+ +++PV + ET LGV +RAF +RF VD +
Sbjct: 1127 FFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1186
Query: 371 SLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQI 430
++ S VA WL +R+E + N V+ AAL ++ + LS G VGLS+SY+L +
Sbjct: 1187 KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI-SRHSLSAGLVGLSVSYSLQVTTYLN 1245
Query: 431 FWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPN 490
+ R S + I++VER+K++ E P + PPSSWP G+++ + +RYR +
Sbjct: 1246 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
Query: 491 APLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKD 550
VL+ I T GG +VG+VGRTG+GKS+L LFR+ E + G+I+IDGINI +GL D
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 551 LRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSD 610
LR K++IIPQ+P LF GS+R NLDP YSD+E+W ++E LK+ +S LP LD ++
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 611 EGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVA 670
G N S+GQRQL CL R LL++ +ILVLDEATA++D TD ++Q IR +FE+CTV+T+A
Sbjct: 1426 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1485
Query: 671 HRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 712
HR+ T++D V+VL G++ EY PS L+ F + +
Sbjct: 1486 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKD 1527
Score = 88.6 bits (218), Expect = 5e-17
Identities = 71/285 (24%), Positives = 137/285 (47%), Gaps = 21/285 (7%)
Query: 437 SNLSNYIISVERIKQFI-HIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVL 495
S++ +S++R++ F+ H EP +I RP I ++ + + P L
Sbjct: 604 SSIVQASVSLKRLRIFLSHEELEPDSI--ERRPVKDGGGTNSITVRNATFTWARSDPPTL 661
Query: 496 KGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKL 555
GIT + G+ V VVG+ G GKS+L+SAL ++ G + I G +
Sbjct: 662 NGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SV 708
Query: 556 SIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGN 614
+ +PQ+ + S+R N+ G ++ +++V + C L + LPS + + ++G N
Sbjct: 709 AYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVN 767
Query: 615 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRII--RQEFEECTVITVAH 671
S GQ+Q L R + I + D+ +++D+ I + +I + + T I V H
Sbjct: 768 LSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTH 827
Query: 672 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSS 716
+ + D+++V+S GK+ E +L+ + +F++ + Y S+
Sbjct: 828 SMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAST 872
>MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2)
Length = 1543
Score = 458 bits (1178), Expect = e-128
Identities = 285/777 (36%), Positives = 418/777 (53%), Gaps = 68/777 (8%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMT--ALRDKTVILVTH 58
+SGGQK R+ LARA Y DADIY+LDDP SAVD H +FN V L KT ILVTH
Sbjct: 759 LSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTH 818
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLL-KSG--------------------------- 87
+ FL +VD I+ G +++ GSY +L+ K G
Sbjct: 819 GIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDSEE 878
Query: 88 ---------TAFELLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSI 138
T E+ A +T+ N LS S +S +I S+
Sbjct: 879 EDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALN 938
Query: 139 -------GAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFW 191
G +L ++E G V + Y+ + +VI ++A +N W
Sbjct: 939 KKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLNYVAF-IGTNLW 997
Query: 192 LA---TAIEIPKVTDTT------LIGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSS 242
L+ + E TD + IGV+ L I+ F+ S ++ AS
Sbjct: 998 LSAWTSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQ 1057
Query: 243 FTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASV 295
T+I APM FFD+TP + D+S +D +P +L + ++ + +I
Sbjct: 1058 LLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMA 1117
Query: 296 TWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMV 355
T +I+ +P + + +Q +Y AT+R+L R++ TK+P+ + +ET G+ +RAF
Sbjct: 1118 TPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQ 1177
Query: 356 DRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRV 415
RF N K +DT+ F + WL +R+E + NL V +ALLL++ + L+ V
Sbjct: 1178 QRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIY-KNSLTGDTV 1236
Query: 416 GLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSK 475
G LS AL + + R S + I++VERI ++I++ E P + D +PP+ WP K
Sbjct: 1237 GFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDK-KPPADWPKK 1295
Query: 476 GKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGD 535
G+I +VRYRP LVLKGITC K +VGVVGRTG+GKS+L + LFR++E + G
Sbjct: 1296 GEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQ 1355
Query: 536 ILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKE 595
I+IDGI+I S+GL DLR +L+IIPQ+P LF G++R NLDP YSD+EIW+A+E LK
Sbjct: 1356 IIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKS 1415
Query: 596 TISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQR 655
++ L L V++ G N S+GQRQL CLGR +L++++ILVLDEATA++D TD+++Q
Sbjct: 1416 FVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQT 1475
Query: 656 IIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 712
IR EF +CTVIT+AHR+ T++DSD +MVL GK+VEY P +L+ F + E
Sbjct: 1476 TIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSNMGPFYLMAKE 1532
Score = 80.1 bits (196), Expect = 2e-14
Identities = 105/530 (19%), Positives = 207/530 (38%), Gaps = 38/530 (7%)
Query: 209 VYALLSISSTS----FVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPASSDL 264
+YA+L S T F+ F +LG+ T +S L +
Sbjct: 360 IYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETV 419
Query: 265 SILDFDIPYSLTCVAIV------AIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQ 318
+++ D + + +++ + IF + ++ V MV L+ +
Sbjct: 420 NLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLA 479
Query: 319 ATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFK--NYLKLVDTDASLFFHS 376
R++ N K + E G+ ++ F F + N ++ + L F
Sbjct: 480 TKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQ 539
Query: 377 NVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWF 436
+ +L + L ++VIT ++ +++ Q L+ + S++ L
Sbjct: 540 LQTILIFILHLTPTL-VSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVI 598
Query: 437 SNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLK 496
S++ +SV+R+++++ +D + + + + ++
Sbjct: 599 SSVIQASVSVDRLERYLGSDD-----LDLSAIRHVCHFDKAVQFSEASFTWDRDLEATIQ 653
Query: 497 GITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLS 556
+ K G V VVG GSGKS+LISA+ +E G I I G ++
Sbjct: 654 DVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKG-------------SIA 700
Query: 557 IIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWS 616
+PQ+ + G+I+ N+ Y + + + +E C L + LP + + ++G N S
Sbjct: 701 YVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLS 760
Query: 617 LGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAHRV 673
GQ+ L R + I +LD+ +++D+ I +++ T I V H +
Sbjct: 761 GGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGI 820
Query: 674 PTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSSCRKNSLP 723
+ D ++VL G ++E S LMD F+K W + K+S P
Sbjct: 821 HFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAK----NWKTFMKHSGP 866
>MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4
(MRP/cMOAT-related ABC transporter) (Multi-specific
organic anion tranporter-B) (MOAT-B)
Length = 1325
Score = 457 bits (1177), Expect = e-128
Identities = 274/748 (36%), Positives = 419/748 (55%), Gaps = 43/748 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRDKTVILVTHQV 60
+SGGQK R+ LARAVY DADIYLLDDP SAVDA + LF C+ L +K ILVTHQ+
Sbjct: 535 LSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL 594
Query: 61 EFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLNQNSEVLSNPQDS 117
++L IL DGK++Q G+Y LKSG F L+ N+ ++ V P
Sbjct: 595 QYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKD----NEESEQPPVPGTPTLR 650
Query: 118 HGFYLTKN---QSEGEISSIQGSIGAQLTQ-------EEEKVIGNVGWKPLWDYINYSNG 167
+ + + Q S G++ +Q T+ EE + G VG++ +Y
Sbjct: 651 NRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAH 710
Query: 168 TLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTL---------------IGVYAL 212
++ +IL ++WL+ + + T+ +G+Y+
Sbjct: 711 WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770
Query: 213 LSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLS 265
L++++ F RS + + +S + SI AP+LFFD P S D+
Sbjct: 771 LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830
Query: 266 ILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELI 325
LD +P + ++V+ ++ V +V + I VP + IF+++Y+ T+R++
Sbjct: 831 HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVK 890
Query: 326 RINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVL 385
R+ TT++PV + + + G+ T+RA+ +R + + D + +F W +
Sbjct: 891 RLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAV 950
Query: 386 RIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIIS 445
R++A+ + VI A ++L + L G+VGL+LSYALTL G + R + + N +IS
Sbjct: 951 RLDAICAMFVIIVAFGSLILAKT-LDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMIS 1009
Query: 446 VERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGG 505
VER+ ++ + E P RPP +WP +G I + Y P PLVLK +T K
Sbjct: 1010 VERVIEYTDLEKEAPWEYQK-RPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQ 1068
Query: 506 SRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLF 565
+VG+VGRTG+GKS+LISALFRL EP G I ID I +GL DLR K+SIIPQEP LF
Sbjct: 1069 EKVGIVGRTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLF 1127
Query: 566 KGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCL 625
G++R NLDP ++D+E+W A+++ QLKETI LP +D+ +++ G N+S+GQRQL CL
Sbjct: 1128 TGTMRKNLDPFKEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCL 1187
Query: 626 GRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVL 685
R +L++N+IL++DEATA++D TD ++Q+ IR++F CTV+T+AHR+ T+IDSD +MVL
Sbjct: 1188 ARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVL 1247
Query: 686 SYGKLVEYDEPSKLMDTNSS-FSKLVAE 712
G+L EYDEP L+ S F K+V +
Sbjct: 1248 DSGRLKEYDEPYVLLQNKESLFYKMVQQ 1275
Score = 88.6 bits (218), Expect = 5e-17
Identities = 73/298 (24%), Positives = 141/298 (46%), Gaps = 29/298 (9%)
Query: 422 ALTLNGA-----QIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKG 476
A+TL GA +F+ +S I+S+ RI+ F+ + I NR PS G
Sbjct: 354 AVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDE----ISQRNR---QLPSDG 406
Query: 477 K--IDLQGLEVRY-RPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSR 533
K + +Q + + + L+G++ T + G + VVG G+GKS+L+SA+ + PS
Sbjct: 407 KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSH 466
Query: 534 GDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQL 593
G + + G +++ + Q+P +F G++R+N+ Y + K ++ C L
Sbjct: 467 GLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACAL 513
Query: 594 KETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-I 652
K+ + L + + D G S GQ+ L R + + I +LD+ +++D+ +
Sbjct: 514 KKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHL 573
Query: 653 LQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLV 710
+ I Q E I V H++ + + +++L GK+V+ ++ + + F L+
Sbjct: 574 FELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631
>MRP2_RABIT (Q28689) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2) (Multidrug resistance-associated protein 2)
(Canalicular multidrug resistance protein) (Epithelial
basolateral chloride conductance r
Length = 1564
Score = 457 bits (1177), Expect = e-128
Identities = 287/780 (36%), Positives = 422/780 (53%), Gaps = 74/780 (9%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMT--ALRDKTVILVTH 58
+SGGQKQRI LARA Y ++DIY+LDDP SAVDAH +FN + L KT +LVTH
Sbjct: 759 LSGGQKQRISLARASYQNSDIYILDDPLSAVDAHVGKHIFNKVLGPNGLLNGKTRLLVTH 818
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF----ELLV----SAHKVTINDLNQN 107
+ FL +VD I+ +G +++ GSY +LL F ++ V S +VT+ND ++
Sbjct: 819 SLHFLPQVDEIVVVENGTILEKGSYSSLLAKKGVFAKNLKMFVKHTDSEGEVTVNDGSEE 878
Query: 108 ---------SEVLSNPQDSHGFYLTK-----------NQSEGE-ISSIQGSIGAQ---LT 143
S + P+DS L + ++S G + S++ S+ AQ
Sbjct: 879 DDDDDSGLISSIEEFPEDSISLTLKRENSLHRTLSRSSRSSGRRLKSLKNSLKAQNGKTP 938
Query: 144 QEEEKVIGN---------VGWKPLWDYINYSNGTLMSCLV------ILGQCCFLALQTSS 188
+EEE V G G Y+ Y +V +L F+ S
Sbjct: 939 KEEEVVKGQKLIKKEFMETGKVKFSIYLKYLQAIGWCSIVGIIFAYVLNSVAFIG----S 994
Query: 189 NFWLAT---------AIEIPKVTDTTLIGVYALLSISSTSFVYVRSYFAALLGLKASTAF 239
N WL+ P IG++ +L ++ V V S+++A AS
Sbjct: 995 NLWLSAWTSDSNTYNGTNYPASQRDLRIGIFGVLGLAQGLTVLVASFWSASGCAHASNIL 1054
Query: 240 FSSFTTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVI 292
+I APM FF++TP + D+S +D +P SL + + ++ + +I
Sbjct: 1055 HKQLLNNILRAPMSFFNTTPIGRIVNRFAGDISTVDDTLPQSLRSWMMCFLAIISTLIMI 1114
Query: 293 ASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAF 352
T ++ +P + + +Q +Y AT+R+L R++ T++P+ + ET G+ +RAF
Sbjct: 1115 CMATPVFAVIIIPLAIIYVAVQVFYVATSRQLRRLDSVTRSPIYSHFTETVSGLPVIRAF 1174
Query: 353 NMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSP 412
RF K +DT+ + WL R+E + NL V ++AL++++ LS
Sbjct: 1175 EHQQRFLKQNEIGIDTNQKCVSSWITSNRWLAFRLELVGNLVVFSSALMMVIYRDT-LSG 1233
Query: 413 GRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSW 472
VG LS AL + + R S I++VERI ++I + E P + D RPP+ W
Sbjct: 1234 DVVGFVLSNALNITQTLNWLVRMTSETETNIVAVERITEYIKVENEAPWVTDK-RPPAGW 1292
Query: 473 PSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPS 532
P KG+I +VRYRP LVLKGI C K ++GVVGRTG+GKS+L + LFR++E +
Sbjct: 1293 PHKGEIQFSNYQVRYRPELDLVLKGINCDIKSMEKIGVVGRTGAGKSSLTNCLFRILEAA 1352
Query: 533 RGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQ 592
G I IDGI+I S+GL DLR KL+IIPQ+P LF GS+R NLDP YSD+EIW+A+E
Sbjct: 1353 GGHITIDGIDIASIGLHDLRGKLTIIPQDPVLFSGSLRMNLDPFNNYSDEEIWRALELAH 1412
Query: 593 LKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAI 652
LK ++ L L VS+ N S+GQRQL CLGR LL++++ILVLDEATA++D TD +
Sbjct: 1413 LKSFVAGLQHGLSREVSEAEDNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDHL 1472
Query: 653 LQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 712
+Q IR EF CTVIT+AHR+ T++DSD +MVL G +VEY P +L+++ FS + E
Sbjct: 1473 IQTTIRNEFSHCTVITIAHRLHTIMDSDKIMVLDNGNIVEYGSPEELLESAGPFSLMAKE 1532
Score = 67.4 bits (163), Expect = 1e-10
Identities = 53/222 (23%), Positives = 98/222 (43%), Gaps = 16/222 (7%)
Query: 490 NAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLK 549
N ++ + G V VVG GSGKS+L+SA+ +E G I I G
Sbjct: 647 NLEPTIRNVNLDIMPGQLVAVVGTVGSGKSSLMSAMLGEMENVHGHITIKGTT------- 699
Query: 550 DLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVS 609
+ +PQ+ + G+I+ N+ + + + +E C L + LP + +
Sbjct: 700 ------AYVPQQSWIQNGTIKDNILFGAEFDERRYQRVLEACALLPDLEILPGGDLAEIG 753
Query: 610 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTV 666
++G N S GQ+Q L R + + I +LD+ +++D+ I +++ T
Sbjct: 754 EKGINLSGGQKQRISLARASYQNSDIYILDDPLSAVDAHVGKHIFNKVLGPNGLLNGKTR 813
Query: 667 ITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSK 708
+ V H + + D ++V+ G ++E S L+ F+K
Sbjct: 814 LLVTHSLHFLPQVDEIVVVENGTILEKGSYSSLLAKKGVFAK 855
>MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5
Length = 1436
Score = 456 bits (1172), Expect = e-127
Identities = 272/742 (36%), Positives = 413/742 (55%), Gaps = 44/742 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRDKTVILVTHQV 60
+SGGQ+QRI LARA+Y+D IY+LDDP SA+DAH +FN + L+ KTV+ VTHQ+
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQL 744
Query: 61 EFLSEVDTIL---DGKVIQSGSYENLLKSG----TAFE--LLVSAHKVTINDLNQNSEVL 111
++L + D ++ +G + + G++E L+ T F LL V IN + S
Sbjct: 745 QYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEASG-- 802
Query: 112 SNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMS 171
S G + E + S +G QL Q EEK G+V W W YI + G L
Sbjct: 803 SQKSQDKGPKPGSVKKEKAVKSEEG----QLVQVEEKGQGSVPWSVYWVYIQAAGGPLAF 858
Query: 172 CLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTLIGVYALLSISSTSFVYVRSYFA--- 228
++++ + S +WL+ I+ T G + +S S +++ Y +
Sbjct: 859 LVIMVLFMLNVGSTAFSTWWLSYWIKQGSGNSTVFEGNRSSVSDSMRDNPFLQYYASIYA 918
Query: 229 ----------ALLG-------LKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDL 264
A+ G L+AS+ I +PM FFD+TP S D+
Sbjct: 919 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 978
Query: 265 SILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATAREL 324
+D +P+ I V + +IA V L+ P ++ + + REL
Sbjct: 979 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSVLHIVSRVLIREL 1038
Query: 325 IRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLV 384
R++ T++P ++ + G+ T+ A+N F Y +L+D + + FF AM WL
Sbjct: 1039 KRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLA 1098
Query: 385 LRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYII 444
+R++ L+++ +IT L+I+L + GL++SYA+ L G F R S
Sbjct: 1099 VRLD-LISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFT 1157
Query: 445 SVERIKQFIH-IPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFK 503
SVERI +I + E PA + N PP WP +G+I + E+RYR N PLVLK ++ T K
Sbjct: 1158 SVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIK 1217
Query: 504 GGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPT 563
++G+VGRTGSGKS+L ALFRLVE S G I IDG+ I +GL DLR KL+IIPQEP
Sbjct: 1218 PKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEPV 1277
Query: 564 LFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLF 623
LF G++R+NLDP Y++++IW A+E+ +KE I++LP L+S V + G N+S+G+RQL
Sbjct: 1278 LFSGTVRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLL 1337
Query: 624 CLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVM 683
C+ R LL+ +IL+LDEATA++D+ TD ++Q IR+ F +CT++T+AHR+ TV+ SD +M
Sbjct: 1338 CIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIM 1397
Query: 684 VLSYGKLVEYDEPSKLMDTNSS 705
VL+ G++VE+D PS L+ +SS
Sbjct: 1398 VLAQGQVVEFDTPSVLLSNDSS 1419
Score = 82.4 bits (202), Expect = 4e-15
Identities = 64/250 (25%), Positives = 115/250 (45%), Gaps = 21/250 (8%)
Query: 462 IVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTL 521
++D++ PS +GK G R L I + G VG+ G GSGK++L
Sbjct: 550 LLDSDERPSPEEEEGKQIHAGSMRLQR-----TLYNIDLEIEEGKLVGICGSVGSGKTSL 604
Query: 522 ISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSD 581
ISA+ + G I + G + + Q+ + ++R N+ G D
Sbjct: 605 ISAILGQMTLLEGSIAVSGT-------------FAYVAQQAWILNATLRDNI-LFGKEFD 650
Query: 582 DEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDE 640
+E + +V C L+ ++ LP+ + + + G N S GQRQ L R L I +LD+
Sbjct: 651 EERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
Query: 641 ATASIDS-ATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKL 699
+++D+ + I IR+ + TV+ V H++ ++D D V+ + G + E +L
Sbjct: 711 PLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770
Query: 700 MDTNSSFSKL 709
M+ N ++ +
Sbjct: 771 MNLNGDYATI 780
>MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1528
Score = 454 bits (1168), Expect = e-127
Identities = 271/759 (35%), Positives = 416/759 (54%), Gaps = 49/759 (6%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCV--MTALRDKTVILVTH 58
+SGGQKQR+ LARAVY+++DIYL DDP SAVDAH +F V M L++KT ILVTH
Sbjct: 768 LSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTH 827
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLNQNSEVLSNP- 114
+ +L +VD I+ GK+ + GSY+ LL AF + + DL + +S
Sbjct: 828 GISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSG 887
Query: 115 ------------QDSHGFYLTKNQSE-----GEISSIQGSIGA-----------QLTQEE 146
D+ G +L ++ S G+ S SI +L + +
Sbjct: 888 KESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEAD 947
Query: 147 EKVIGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTL 206
+ G V W+Y+ + G ++ L I C +SN+WL+ + P V + T
Sbjct: 948 KAQTGQVQLSVYWNYMK-AIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQ 1006
Query: 207 ------IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA 260
+ VY L I + ++ S ++ G+ AS ++ +PM FF+ TP+
Sbjct: 1007 ANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPS 1066
Query: 261 -------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFI 313
S +L +D IP + V+ + +I T ++ P + F+
Sbjct: 1067 GNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFV 1126
Query: 314 QKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLF 373
Q++Y A++R+L R+ +++PV + ET LGV +RAF +RF VD + +
Sbjct: 1127 QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAY 1186
Query: 374 FHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWT 433
+ S VA WL +R+E + N V+ AAL ++ + LS G VGLS+SY+L + +
Sbjct: 1187 YPSIVANRWLAVRLECVGNCIVLFAALFAVI-SRHSLSAGLVGLSVSYSLQITAYLNWLV 1245
Query: 434 RWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPL 493
R S + I++VER+K++ E P + PPS+WP G+++ + +RYR + L
Sbjct: 1246 RMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDL 1305
Query: 494 VLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRM 553
VLK I T +GG +VG+VGRTG+GKS+L LFR+ E + G+I+IDG+NI +GL +LR
Sbjct: 1306 VLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRF 1365
Query: 554 KLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGG 613
K++IIPQ+P LF GS+R NLDP YSD+E+W A+E LK +S LP L+ ++ G
Sbjct: 1366 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGE 1425
Query: 614 NWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRV 673
N S+GQRQL CL R LL++ +ILVLDEATA++D TD ++Q IR +FE+CTV+T+AHR+
Sbjct: 1426 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRL 1485
Query: 674 PTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 712
T++D V+VL G++ E PS+L+ F + +
Sbjct: 1486 NTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAKD 1524
Score = 87.4 bits (215), Expect = 1e-16
Identities = 71/282 (25%), Positives = 134/282 (47%), Gaps = 22/282 (7%)
Query: 437 SNLSNYIISVERIKQFI-HIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVL 495
S++ +S++R++ F+ H EP +I R I ++ + P L
Sbjct: 605 SSIVQASVSLKRLRIFLSHEELEPDSI---ERRSIKSGEGNSITVKNATFTWARGEPPTL 661
Query: 496 KGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKL 555
GIT + G+ V VVG+ G GKS+L+SAL ++ G + + G +
Sbjct: 662 NGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKG-------------SV 708
Query: 556 SIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGN 614
+ +PQ+ + S+R N+ G + +KAV E C L + LPS + + ++G N
Sbjct: 709 AYVPQQAWIQNDSLRENI-LFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVN 767
Query: 615 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAH 671
S GQ+Q L R + + I + D+ +++D+ I ++++ + T I V H
Sbjct: 768 LSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTH 827
Query: 672 RVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEY 713
+ + D+++V+S GK+ E +L+D + +F++ + Y
Sbjct: 828 GISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTY 869
>MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (ABC
transporter MOAT-C) (SMRP)
Length = 1436
Score = 452 bits (1162), Expect = e-126
Identities = 266/740 (35%), Positives = 410/740 (54%), Gaps = 40/740 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRDKTVILVTHQV 60
+SGGQ+QRI LARA+Y+D IY+LDDP SA+DAH +FN + L+ KTV+ VTHQ+
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQL 744
Query: 61 EFLSEVDTIL---DGKVIQSGSYENLLKSG----TAFELLVSAHKVTINDLNQNSEVLSN 113
++L + D ++ +G + + G++E L+ T F L+ + ++ S
Sbjct: 745 QYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEATGSQ 804
Query: 114 PQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCL 173
G + E + S +G QL Q EEK G+V W W YI + G L +
Sbjct: 805 KSQDKGPKPGSVKKEKAVKSEEG----QLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLV 860
Query: 174 VILGQCCFLALQTSSNFWLATAIEIPKVTDTTLIGVYALLSISSTSFVYVRSYFA----- 228
+++ + S +WL+ I+ T G + +S S +++ Y +
Sbjct: 861 IMVLFMLNVGSTAFSTWWLSYWIKQGSGNSTVYQGNRSFVSDSMKDNPFMQYYASIYALS 920
Query: 229 --------ALLG-------LKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSI 266
A+ G L+AS+ I +PM FFD+TP S D+
Sbjct: 921 MAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDE 980
Query: 267 LDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIR 326
+D +P+ I V + +IA V L+ P ++ + + REL R
Sbjct: 981 VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSLLHIVSRVLIRELKR 1040
Query: 327 INGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLR 386
++ T++P ++ + G+ T+ A+N F Y +L+D + + FF AM WL +R
Sbjct: 1041 LDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLPVR 1100
Query: 387 IEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISV 446
++ ++++ +IT+ L+I+ GL++SYA+ L G F R S SV
Sbjct: 1101 LD-IISIALITSTGLMIVSGMARSLSAYAGLAISYAVQLIGLFQFTVRLASETEARFTSV 1159
Query: 447 ERIKQFIH-IPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGG 505
ERI +I + E PA + N PP WP +G++ + E+RYR N PLVLK ++ T K
Sbjct: 1160 ERINHYIKTLSLEAPARIKNKAPPHDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPK 1219
Query: 506 SRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLF 565
++G+VGRTGSGKS+L ALFRLVE S G I IDGI I +GL DLR KL+IIPQEP LF
Sbjct: 1220 EKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLF 1279
Query: 566 KGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCL 625
G++R+NLDP Y++D+IW A+E+ +KE I++LP L+S V + G N+S+G+RQL C+
Sbjct: 1280 SGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCI 1339
Query: 626 GRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVL 685
R LL+ +IL+LDEATA++D+ TD ++Q IR+ F +CT++T+AHR+ TV+ SD +MVL
Sbjct: 1340 ARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVL 1399
Query: 686 SYGKLVEYDEPSKLMDTNSS 705
+ G++VE+D PS L+ +SS
Sbjct: 1400 AQGQVVEFDTPSVLLSNDSS 1419
Score = 82.0 bits (201), Expect = 5e-15
Identities = 63/251 (25%), Positives = 117/251 (46%), Gaps = 23/251 (9%)
Query: 462 IVDNNRPPSSWPSKGK-IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKST 520
++D++ PS +GK I L ++ L I + G VG+ G GSGK++
Sbjct: 550 LLDSDERPSPEEEEGKQIHTGSLRLQR------TLYNIDLEIEEGKLVGICGSVGSGKTS 603
Query: 521 LISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYS 580
L+SA+ + G I + G + + Q+ + ++R N+ G
Sbjct: 604 LVSAILGQMTLLEGSIAVSGT-------------FAYVAQQAWILNATLRDNI-LFGKEF 649
Query: 581 DDEIWKAV-EKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLD 639
D+E + +V C L+ ++ LP+ + + + G N S GQRQ L R L I +LD
Sbjct: 650 DEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILD 709
Query: 640 EATASIDS-ATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSK 698
+ +++D+ + I IR+ + TV+ V H++ ++D D V+ + G + E +
Sbjct: 710 DPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEE 769
Query: 699 LMDTNSSFSKL 709
LM+ N ++ +
Sbjct: 770 LMNLNGDYATI 780
>MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5
(Multi-specific organic anion tranporter-C) (MOAT-C)
(pABC11) (SMRP)
Length = 1437
Score = 451 bits (1161), Expect = e-126
Identities = 271/742 (36%), Positives = 406/742 (54%), Gaps = 43/742 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRDKTVILVTHQV 60
+SGGQ+QRI LARA+Y+D IY+LDDP SA+DAH +FN + L+ KTV+ VTHQ+
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQL 744
Query: 61 EFLSEVDTIL---DGKVIQSGSYENLLKSG----TAFE--LLVSAHKVTINDLNQNSEVL 111
++L + D ++ +G + + G++E L+ T F LL V IN + S
Sbjct: 745 QYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQ 804
Query: 112 SNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMS 171
QD K S + +++ G QL Q EEK G+V W YI + G L
Sbjct: 805 KKSQDKG----PKTGSVKKEKAVKPEEG-QLVQLEEKGQGSVPWSVYGVYIQAAGGPLAF 859
Query: 172 CLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTLIG--------------------VYA 211
+++ + S +WL+ I+ T G +YA
Sbjct: 860 LVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYA 919
Query: 212 LLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDL 264
L +R L+AS+ I +PM FFD+TP S D+
Sbjct: 920 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 979
Query: 265 SILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATAREL 324
+D +P+ I V + +IA V L+ P ++ + + REL
Sbjct: 980 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIREL 1039
Query: 325 IRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLV 384
R++ T++P ++ + G+ T+ A+N F Y +L+D + + FF AM WL
Sbjct: 1040 KRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLA 1099
Query: 385 LRIEALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYII 444
+R++ L+++ +IT L+I+L + P GL++SYA+ L G F R S
Sbjct: 1100 VRLD-LISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFT 1158
Query: 445 SVERIKQFIH-IPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFK 503
SVERI +I + E PA + N P WP +G++ + E+RYR N PLVLK ++ T K
Sbjct: 1159 SVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIK 1218
Query: 504 GGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPT 563
++G+VGRTGSGKS+L ALFRLVE S G I IDG+ I +GL DLR KLSIIPQEP
Sbjct: 1219 PKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPV 1278
Query: 564 LFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLF 623
LF G++R+NLDP Y++D+IW A+E+ +KE I++LP L+S V + G N+S+G+RQL
Sbjct: 1279 LFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLL 1338
Query: 624 CLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVM 683
C+ R LL+ +IL+LDEATA++D+ TD ++Q IR+ F +CT++T+AHR+ TV+ SD +M
Sbjct: 1339 CIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIM 1398
Query: 684 VLSYGKLVEYDEPSKLMDTNSS 705
VL+ G++VE+D PS L+ +SS
Sbjct: 1399 VLAQGQVVEFDTPSVLLSNDSS 1420
Score = 85.5 bits (210), Expect = 5e-16
Identities = 64/250 (25%), Positives = 115/250 (45%), Gaps = 21/250 (8%)
Query: 462 IVDNNRPPSSWPSKGK-IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKST 520
++D++ PS +GK I L L ++ L I + G VG+ G GSGK++
Sbjct: 550 LLDSDERPSPEEEEGKHIHLGHLRLQR------TLHSIDLEIQEGKLVGICGSVGSGKTS 603
Query: 521 LISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYS 580
LISA+ + G I I G + + Q+ + ++R N+ Y
Sbjct: 604 LISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKEYD 650
Query: 581 DDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDE 640
++ + C L+ ++ LPS + + + G N S GQRQ L R L I +LD+
Sbjct: 651 EERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
Query: 641 ATASIDS-ATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKL 699
+++D+ + I IR+ + TV+ V H++ ++D D V+ + G + E +L
Sbjct: 711 PLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770
Query: 700 MDTNSSFSKL 709
M+ N ++ +
Sbjct: 771 MNLNGDYATI 780
>MRP2_RAT (Q63120) Canalicular multispecific organic anion transporter
1 (ATP-binding cassette, sub-family C, member 2)
(Multidrug resistance-associated protein 2) (Canalicular
multidrug resistance protein)
Length = 1541
Score = 447 bits (1150), Expect = e-125
Identities = 277/776 (35%), Positives = 417/776 (53%), Gaps = 66/776 (8%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMT--ALRDKTVILVTH 58
+SGGQKQR+ LARA Y DADIY+LDDP SAVDAH +FN V L KT I VTH
Sbjct: 757 LSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTH 816
Query: 59 QVEFLSEVDTI-----------------LDGKVIQSGSYENLLK-SGTAFELLVSAHKVT 100
+ FL +VD I LD K + + +++ +K SG E V+
Sbjct: 817 GIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVNNDSEA 876
Query: 101 INDLNQNSEVLSN-PQDSHGFYLTKNQS-------EGEISSIQGSI-------------- 138
+D + + P+D+ + + S SS +G
Sbjct: 877 EDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLK 936
Query: 139 -------GAQLTQEEEKVIGNVGWKPLWDYINYSNGTLMSCLVI---LGQCCFLALQTSS 188
G +L ++E G V + Y+ + +++ L F+
Sbjct: 937 EKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGLNNVAFIGSNLWL 996
Query: 189 NFWLATAIEIPKVTDTTL-----IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSF 243
+ W + + + +++ IGV+ L ++ + + + ++ AS A
Sbjct: 997 SAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQL 1056
Query: 244 TTSIFNAPMLFFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVT 296
T+I APM FFD+TP S D+S +D +P +L + + + +I T
Sbjct: 1057 LTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMAT 1116
Query: 297 WQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVD 356
I+ +P + I +Q +Y AT+R+L R++ TK+P+ + +ET G+ +RAF
Sbjct: 1117 PVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQ 1176
Query: 357 RFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVG 416
RF K +D + F + WL +R+E + NL V +ALLL++ ++ L+ VG
Sbjct: 1177 RFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIY-RKTLTGDVVG 1235
Query: 417 LSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKG 476
LS AL + + R S I++VERI ++I++ E P + D RPP+ WP G
Sbjct: 1236 FVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPWVTDK-RPPADWPRHG 1294
Query: 477 KIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDI 536
+I +VRYRP LVLKGITC K G +VGVVGRTG+GKS+L + LFR++E + G I
Sbjct: 1295 EIQFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQI 1354
Query: 537 LIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKET 596
+IDGI++ S+GL DLR +L+IIPQ+P LF GS+R NLDP YSD+E+W+A+E L+
Sbjct: 1355 IIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSF 1414
Query: 597 ISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRI 656
+S L L S V++ G N S+GQRQL CLGR +L++++ILVLDEATA++D TD+++Q
Sbjct: 1415 VSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTT 1474
Query: 657 IRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAE 712
IR+EF +CTVIT+AHR+ T++DSD +MVL GK+VEY P +L+ SF + E
Sbjct: 1475 IRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLSNRGSFYLMAKE 1530
Score = 75.9 bits (185), Expect = 4e-13
Identities = 95/455 (20%), Positives = 184/455 (39%), Gaps = 46/455 (10%)
Query: 283 IEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAET 342
I++ + IF + ++ V MV LI + R + N K + E
Sbjct: 442 IQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEI 501
Query: 343 SLGVVTVRAFNMVDRF-----------FKNYLKLVDTDASLFFHSNVAMEWLVLRIEALL 391
G+ ++ F F KN L+ + L F +L+I +L
Sbjct: 502 LSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIF---------ILQITPIL 552
Query: 392 NLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQ 451
++V+T ++ +++ L+ + S++ L S++ +SV+R+++
Sbjct: 553 -VSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLER 611
Query: 452 FIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVV 511
++ + + R S++ K + P+ ++ + K G V VV
Sbjct: 612 YLGGDDLDTSAI---RRVSNFDKAVKFSEASFT--WDPDLEATIQDVNLDIKPGQLVAVV 666
Query: 512 GRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRT 571
G GSGKS+L+SA+ +E G I I G + +PQ+ + G+I+
Sbjct: 667 GTVGSGKSSLVSAMLGEMENVHGHITIQG-------------STAYVPQQSWIQNGTIKD 713
Query: 572 NLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLK 631
N+ Y++ + + ++ C L + LP + + ++G N S GQ+Q L R +
Sbjct: 714 NILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQ 773
Query: 632 RNRILVLDEATASIDSATDA-ILQRIIRQE--FEECTVITVAHRVPTVIDSDMVMVLSYG 688
I +LD+ +++D+ I +++ T I V H + + D ++VL G
Sbjct: 774 DADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKG 833
Query: 689 KLVEYDEPSKLMDTNSSFSKLVAEYWSSCRKNSLP 723
++E L+D F A W + K+S P
Sbjct: 834 TILEKGSYRDLLDKKGVF----ARNWKTFMKHSGP 864
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/108 (31%), Positives = 59/108 (54%), Gaps = 6/108 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRDKTVILVTHQV 60
+S GQ+Q + L RAV + I +LD+ +AVD T + L + TVI + H++
Sbjct: 1433 LSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDS-LIQTTIRKEFSQCTVITIAHRL 1491
Query: 61 EFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLN 105
+ + D I+ +GK+++ GS E LL + +F L+ A + I ++N
Sbjct: 1492 HTIMDSDKIMVLDNGKIVEYGSPEELLSNRGSFYLM--AKEAGIENVN 1537
>MRP3_HUMAN (O15438) Canalicular multispecific organic anion
transporter 2 (Multidrug resistance-associated protein 3)
(Multi-specific organic anion tranporter-D) (MOAT-D)
Length = 1527
Score = 446 bits (1146), Expect = e-124
Identities = 278/771 (36%), Positives = 418/771 (54%), Gaps = 69/771 (8%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMT--ALRDKTVILVTH 58
+SGGQ+QR+ LARAVY+DADI+LLDDP SAVD+H A +F+ + L KT +LVTH
Sbjct: 751 LSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTH 810
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLK-----------------------SGTAFE- 91
+ FL + D I+ DG+V + G Y LL+ S TA E
Sbjct: 811 GISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEG 870
Query: 92 ------LLVSAHKVTINDLNQNSEVLSNPQDSHGFYLTKNQSEGE--------------- 130
LL+ DL N V Q L+ S+GE
Sbjct: 871 AEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSE 930
Query: 131 -ISSIQGSIGAQLTQEEEKVIGNVGWKPLWDYINYSN--GTLMSCLVILGQCCFLALQTS 187
+ + LTQEE+ IG V WDY TL CL+ +GQ A
Sbjct: 931 KVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQS---AAAIG 987
Query: 188 SNFWLAT----AIEIPKVTDTTL-IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSS 242
+N WL+ A+ + +T+L +GVYA L I V + + A G++A+ +
Sbjct: 988 ANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQA 1047
Query: 243 FTTSIFNAPMLFFDSTPASSDLSILDFDIPYSLTCVAIVAIEVLVMIF-------VIASV 295
+ +P FFD+TP+ L+ DI +A V + +L F VI +
Sbjct: 1048 LLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAS 1107
Query: 296 TWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMV 355
T +V +P V +Q++Y AT+R+L R+ +++P+ + +ET G +RA+N
Sbjct: 1108 TPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRS 1167
Query: 356 DRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRV 415
F VD + + ++ WL + +E + N V+ AAL ++ + L+PG V
Sbjct: 1168 RDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVI-GRSSLNPGLV 1226
Query: 416 GLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSK 475
GLS+SY+L + A + R S+L + I++VER+K++ E P +V+ +RPP WP +
Sbjct: 1227 GLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR 1286
Query: 476 GKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGD 535
G+++ + VRYRP LVL+ ++ GG +VG+VGRTG+GKS++ LFR++E ++G+
Sbjct: 1287 GEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGE 1346
Query: 536 ILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKE 595
I IDG+N+ +GL DLR +L+IIPQ+P LF G++R NLDP G YS+++IW A+E L
Sbjct: 1347 IRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHT 1406
Query: 596 TISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQR 655
+S P+ LD S+ G N S+GQRQL CL R LL+++RILVLDEATA+ID TD ++Q
Sbjct: 1407 FVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQA 1466
Query: 656 IIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSF 706
IR +F+ CTV+T+AHR+ T++D V+VL G + E+D P+ L+ F
Sbjct: 1467 TIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
Score = 87.0 bits (214), Expect = 2e-16
Identities = 93/426 (21%), Positives = 176/426 (40%), Gaps = 28/426 (6%)
Query: 291 VIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVR 350
V+A V + VL++ + VA+ + +Q +L + ++N L
Sbjct: 452 VLAGVAFMVLLIPLNGAVAVKM--RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPS 509
Query: 351 AFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYL 410
V+ + L+L+ T A + H+ W+ + +T+IT + + + P L
Sbjct: 510 FLKQVEGIRQGELQLLRTAA--YLHTTTTFTWMC----SPFLVTLITLWVYVYVDPNNVL 563
Query: 411 SPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPS 470
+ +S+S L + SNL+ +S++RI+QF+ P V+
Sbjct: 564 DAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISP 623
Query: 471 SWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVE 530
+ I + + + P L + G+ V VVG G GKS+L+SAL +E
Sbjct: 624 GYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEME 679
Query: 531 PSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEK 590
G + + G ++ +PQ+ + +++ N+ + + +E
Sbjct: 680 KLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEA 726
Query: 591 CQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDS-AT 649
C L + LP + + ++G N S GQRQ L R + I +LD+ +++DS
Sbjct: 727 CALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVA 786
Query: 650 DAILQRIIRQE--FEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFS 707
I +I E T + V H + + +D ++VL+ G++ E L+ N SF+
Sbjct: 787 KHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFA 846
Query: 708 KLVAEY 713
+ Y
Sbjct: 847 NFLCNY 852
>MRP3_RAT (O88563) Canalicular multispecific organic anion transporter
2 (Multidrug resistance-associated protein 3) (MRP-like
protein-2) (MLP-2)
Length = 1522
Score = 440 bits (1132), Expect = e-123
Identities = 271/769 (35%), Positives = 424/769 (54%), Gaps = 68/769 (8%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMT--ALRDKTVILVTH 58
+SGGQ+QR+ LARAVY+DA+I+LLDDP SAVD+H A +F+ + L KT +LVTH
Sbjct: 749 LSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTH 808
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLV---------SAHKVTINDLNQ 106
+ FL + D I+ DG++ + G Y LL+ +F + A++ + N+
Sbjct: 809 GISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANE 868
Query: 107 NSEVLSNPQDSH--------GFYLTKNQ---------SEGE----------ISSIQGSIG 139
+L + +H Y + Q SEGE SS++ +
Sbjct: 869 EVLLLEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVP 928
Query: 140 AQLTQEEEKVI-------GNVGWKPLWDYINYSN--GTLMSCLVILGQCCFLALQTSSNF 190
A T+E +I GNV WDY TL CL+ GQ A+ +N
Sbjct: 929 ATQTKETGALIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICLLYAGQN---AVAIGANV 985
Query: 191 WLAT----AIEIPKVTDTTL-IGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTT 245
WL+ E + +T++ +GVYA L I V + ++ + ++A+ ++
Sbjct: 986 WLSAWTNDVEEHGQQNNTSVRLGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLH 1045
Query: 246 SIFNAPMLFFDSTPASSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVP 305
+ AP FFD+TP+ L+ DI Y + V I +L F + T V++ + P
Sbjct: 1046 NQIRAPQSFFDTTPSGRILNRFSKDI-YVIHEVLAPTILMLFNSFYTSISTIVVIVASTP 1104
Query: 306 AMVALI--------FIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDR 357
++ F+Q++Y AT+R+L R+ +++P+ + +ET G +RA+ V
Sbjct: 1105 LFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQD 1164
Query: 358 FFKNYLKLVDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLILLPQRYLSPGRVGL 417
F VD++ + + WL + +E + N V+ +AL ++ + L+PG VGL
Sbjct: 1165 FKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSALFAVI-GRNSLNPGLVGL 1223
Query: 418 SLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGK 477
S+SYAL + + + R S+L + II+VER+K++ E P ++++NR P WP G
Sbjct: 1224 SVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGV 1283
Query: 478 IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIL 537
++ + VRYRP LVLK +T +GG +VG+VGRTG+GKS++ LFR++E + G+I
Sbjct: 1284 VEFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIF 1343
Query: 538 IDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETI 597
IDG+N+ +GL DLR +L+IIPQ+P LF G++R NLDP G YSD++IW+ +E L +
Sbjct: 1344 IDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFV 1403
Query: 598 SKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRII 657
S P+ LD S+ G N S+GQRQL CL R LL+++R+LVLDEATA+ID TD ++Q I
Sbjct: 1404 SSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTI 1463
Query: 658 RQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSF 706
R +FE+CTV+T+AHR+ T++D + V+VL G + E+D P L+ F
Sbjct: 1464 RTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIF 1512
Score = 82.0 bits (201), Expect = 5e-15
Identities = 76/325 (23%), Positives = 142/325 (43%), Gaps = 22/325 (6%)
Query: 393 LTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQF 452
+T+IT + + + L + +SLS L + S ++ +S++RI+ F
Sbjct: 544 VTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSLKRIQDF 603
Query: 453 IHIPAEPPAIVDNNRPPSSWPSKGK-IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVV 511
++ P V+ S G+ I + + + P L I G+ V VV
Sbjct: 604 LNQDELDPQCVERKTI-----SPGRAITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVV 658
Query: 512 GRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKGSIRT 571
G G GKS+L+SAL +E G + + G ++ +PQ+ + +++
Sbjct: 659 GPVGCGKSSLVSALLGEMEKLEGAVSVKG-------------SVAYVPQQAWIQNCTLQE 705
Query: 572 NLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLK 631
N+ + +A+E C L + LP + + ++G N S GQRQ L R +
Sbjct: 706 NVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS 765
Query: 632 RNRILVLDEATASIDS-ATDAILQRIIRQE--FEECTVITVAHRVPTVIDSDMVMVLSYG 688
I +LD+ +++DS I ++I E T + V H + + +D ++VL+ G
Sbjct: 766 DANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG 825
Query: 689 KLVEYDEPSKLMDTNSSFSKLVAEY 713
++ E S+L+ + SF+ + Y
Sbjct: 826 QITEMGHYSELLQHDGSFANFLRNY 850
>YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium
factor 1)
Length = 1515
Score = 432 bits (1111), Expect = e-120
Identities = 269/766 (35%), Positives = 408/766 (53%), Gaps = 51/766 (6%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCV--MTALRDKTVILVTH 58
+SGGQK R+ LARAVY AD YLLDDP +AVD H A L + L KT +L T+
Sbjct: 753 LSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATN 812
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKS-----------------------GTAFEL 92
+V LS D+I +G++ Q G+Y+ + K G + E
Sbjct: 813 KVSALSIADSIALLDNGEITQQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFGDSSES 872
Query: 93 LVSAHKVTI-NDLNQNSEVLSNPQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIG 151
V + + +L Q ++ + + S+ + SI + + E + G
Sbjct: 873 SVRESSIPVEGELEQLQKLNDLDFGNSDAISLRRASDATLGSIDFGDDENIAKREHREQG 932
Query: 152 NVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEI-----PKVTDTTL 206
V W +Y N + C+ IL + L N WL E+
Sbjct: 933 KVKWNIYLEYAKACNPKSV-CVFILFIVISMFLSVMGNVWLKHWSEVNSRYGSNPNAARY 991
Query: 207 IGVYALLSISSTSFVYVRSYFA-ALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA----- 260
+ +Y L I S +++ + AS + T S+ APM FF++TP
Sbjct: 992 LAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILN 1051
Query: 261 --SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQ 318
S+D+ +D + + + + A++V I VI + TWQ + + +P V I+ Q+YY
Sbjct: 1052 RFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYL 1111
Query: 319 ATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNV 378
T+REL R++ T++P+ + ET G+ TVR ++ RF +D + S F+ S
Sbjct: 1112 RTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPSIN 1171
Query: 379 AMEWLVLRIEALLNLTVITAALLLIL-LPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFS 437
A WL R+E + ++ ++ AA L + L Q L+ G VGLSLSYAL + + R
Sbjct: 1172 ANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRMTV 1231
Query: 438 NLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKG 497
+ I+SVERIK++ + +E P IV+ +RPP WPS+G I RYRP LVLK
Sbjct: 1232 EVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDIKFNNYSTRYRPELDLVLKH 1291
Query: 498 ITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSI 557
I K +VG+VGRTG+GKS+L ALFR++E S G+I+ID I I +GL DLR KLSI
Sbjct: 1292 INIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSI 1351
Query: 558 IPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKE-TISKLPSLLDSSVSDEGGNWS 616
IPQ+ +F+G++R N+DP+ Y+D+ IW+A+E LKE +S LD+ +++ GGN S
Sbjct: 1352 IPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLS 1411
Query: 617 LGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTV 676
+GQRQL CL R +L ++ILVLDEATA++D TD ++Q IR F++ T++T+AHR+ T+
Sbjct: 1412 VGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTI 1471
Query: 677 IDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKLVAEYWSSCRKNSL 722
+DSD ++VL GK+ E+D P +L+ N S ++S C + L
Sbjct: 1472 MDSDRIIVLDNGKVAEFDSPGQLLSDNKSL------FYSLCMEAGL 1511
Score = 57.0 bits (136), Expect = 2e-07
Identities = 52/232 (22%), Positives = 103/232 (43%), Gaps = 21/232 (9%)
Query: 488 RPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMG 547
+P + LK I K G+ +VG+ GSGK+ L+S + GD+ G
Sbjct: 639 KPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCML-------GDL------FRVKG 685
Query: 548 LKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSS 607
+ ++ + Q P + G+++ N+ Y + K ++ C L ++ L +
Sbjct: 686 FATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTL 745
Query: 608 VSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDS-ATDAILQRIIRQE--FEEC 664
V ++G + S GQ+ L R + R +LD+ A++D +++ ++
Sbjct: 746 VGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTK 805
Query: 665 TVITVAHRVPTVIDSDMVMVLSYGKLVE---YDEPSKLMDTNSSFSKLVAEY 713
T + ++V + +D + +L G++ + YDE +K D +S KL+ Y
Sbjct: 806 TKVLATNKVSALSIADSIALLDNGEITQQGTYDEITK--DADSPLWKLLNNY 855
>YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c
Length = 1478
Score = 423 bits (1088), Expect = e-118
Identities = 277/752 (36%), Positives = 411/752 (53%), Gaps = 53/752 (7%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTA--LRDKTVILVTH 58
+SGGQK RI LARAVY+ +DIYLLDD SAVD H L + + + LR + VIL T+
Sbjct: 721 LSGGQKARISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTN 780
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTA--FELLVSAHKVTI-------NDLNQ 106
+ L E I +GK+I+SGS+ L S + F+LL K L++
Sbjct: 781 SLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQLLSEFSKKDTASSTGADTPLSR 840
Query: 107 NSEVLSNPQD-----SHGFYLTKNQSEGEISSIQGSIGAQLTQE----------EEKVIG 151
+ V+++ D S N + I G I +LT E E+ G
Sbjct: 841 SQSVITSSTDVTSSASRSSDTVSNYPKATIKGT-GRIRKRLTDEDNVKATGQAAEKMERG 899
Query: 152 NVGWKPLWDYINYSNGTLMSC--LVILGQCCFLALQTSSNFWLATAIEI-------PKVT 202
V WK W Y + L+ L I+G + + +N WL E+ PK
Sbjct: 900 KVKWKVYWTYFKACSLFLIFLYFLFIIGG---IGMNVGTNVWLKHWSEVNTQLGYNPK-- 954
Query: 203 DTTLIGVYALLSISSTSFVYVRSY-FAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPAS 261
+G+Y L + S + + + S +K+ S ++ APM FF++TP
Sbjct: 955 PYFYLGIYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTPTG 1014
Query: 262 SDLSILDFDIPYSLTCVAIVAI----EVLVMIFVIASVTWQ---VLIVAVPAMVALIFIQ 314
L+ D+ ++ V + + ++FV+A + + +I+ VP + Q
Sbjct: 1015 RILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYRYNQ 1074
Query: 315 KYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFF 374
YY T+REL R++ T++P+ E+ G+ T+RA++M D F VDT+ ++F
Sbjct: 1075 VYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWF 1134
Query: 375 HSNVAMEWLVLRIEALLNLTVITAALLLILLPQR-YLSPGRVGLSLSYALTLNGAQIFWT 433
+ W +R+EA+ L V ++A +L R + G VGLSLSYA+ + + F
Sbjct: 1135 LYFSSNRWQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTFVV 1194
Query: 434 RWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPL 493
R ++ I+SVER+ ++I +P+E P+I+ ++RPP WPS G I VRYR N PL
Sbjct: 1195 RQSVDVETNIVSVERMLEYIGLPSEAPSIIPDHRPPEGWPSHGAIKFDHYSVRYRENLPL 1254
Query: 494 VLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRM 553
VL I+ K ++G+VGRTG+GKSTL ALFRL+EP+ GDI +D INI S+GL DLR
Sbjct: 1255 VLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRS 1314
Query: 554 KLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGG 613
+L+IIPQE F+G+IR NLDP +D+EIW A+E LK+ I L L S V++ G
Sbjct: 1315 RLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEGGA 1374
Query: 614 NWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRV 673
N S GQRQL CL R LL R+L+LDEATA++D TDAI+QR IR+ F + T++T+AHR+
Sbjct: 1375 NLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAHRI 1434
Query: 674 PTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 705
TV+DS+ ++VL +GK+VE+D KL++ +S
Sbjct: 1435 NTVMDSNRILVLDHGKVVEFDSTKKLLENKAS 1466
Score = 54.7 bits (130), Expect = 9e-07
Identities = 50/224 (22%), Positives = 100/224 (44%), Gaps = 19/224 (8%)
Query: 495 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 554
L+ I + G +VG+ G GKS+L+ A ++ G + G
Sbjct: 614 LRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCG-------------S 660
Query: 555 LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIW-KAVEKCQLKETISKLPSLLDSSVSDEGG 613
++ Q+P + +I+ N+ GL D E + K + C L L + V ++G
Sbjct: 661 IAYAAQQPWILNATIQENI-LFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGI 719
Query: 614 NWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRII---RQEFEECTVITVA 670
+ S GQ+ L R + R+ I +LD+ +++D + L R + + VI
Sbjct: 720 SLSGGQKARISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILST 779
Query: 671 HRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDT-NSSFSKLVAEY 713
+ + + ++ M+ +L GK++E ++L + +S +L++E+
Sbjct: 780 NSLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQLLSEF 823
>BPT1_YEAST (P14772) Bile pigment transporter 1
Length = 1559
Score = 401 bits (1031), Expect = e-111
Identities = 266/793 (33%), Positives = 425/793 (53%), Gaps = 82/793 (10%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVM---TALRDKTVILVT 57
+SGGQK R+ LARAVY+ ADIYLLDD SAVDA + + ++ L++KT+IL T
Sbjct: 770 LSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTT 829
Query: 58 HQVEFLSEVDTIL---DGKVIQSGSYENLL--KSGTA-FELLVSAHKVTINDLNQNSEVL 111
+ V L I +G++++ G+YE+++ K+ T+ + L+ I++ N++
Sbjct: 830 NTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQT 889
Query: 112 SNPQDSH-----GFYLTKNQSEGEI-----------SSIQGS---------IGAQL---- 142
+ +S +T++++E E+ +S + S +GAQL
Sbjct: 890 EHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVGAQLDSVK 949
Query: 143 --TQEEEKV-IGNVGWKPLWDYINYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIP 199
Q+ EK +G V K YI + G L L L + NFWL E
Sbjct: 950 KTAQKAEKTEVGRVKTKIYLAYIK-ACGVLGVVLFFLFMILTRVFDLAENFWLKYWSESN 1008
Query: 200 KVTDTT-----LIGVYALLSISSTSFVYVRSYFAALL-GLKASTAFFSSFTTSIFNAPML 253
+ + +GVY+L+ ++S +F +RS L ++ S S S+ +PM
Sbjct: 1009 EKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMT 1068
Query: 254 FFDSTPA-------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPA 306
FF++TP SSD+ +D ++ Y + + LV + ++ L+ +
Sbjct: 1069 FFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFL 1128
Query: 307 MVALIFIQKYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRF-FKNYLKL 365
+V I+ Q +Y +REL R+ + +P+M+ +E+ G + A++ +RF + NY K
Sbjct: 1129 VVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEK- 1187
Query: 366 VDTDASLFFHSNVAMEWLVLRIEALLNLTVITAALLLI--LLPQRYLSPGRVGLSLSYAL 423
+ + F+ WL +R++ + V+ A+L + + +R LS G VGL +SY+L
Sbjct: 1188 IQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSL 1247
Query: 424 TLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPPAIVDNNRPPSSWPSKGKIDLQGL 483
+ G+ + R + I+SVERI ++ +P E +I RP +WPSKG I+ +
Sbjct: 1248 EVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNY 1307
Query: 484 EVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINI 543
+YR N VL I + +VG+VGRTG+GKSTL ALFR++EP+ G I+IDGI+I
Sbjct: 1308 STKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDI 1367
Query: 544 CSMGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKL--- 600
+GL DLR L+IIPQ+ F+G+++TNLDP YS+DE+ +AVE+ LK + K+
Sbjct: 1368 SDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHS 1427
Query: 601 --------------PSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID 646
+LD +++ G N S+GQRQL CL R LL R++ILVLDEATAS+D
Sbjct: 1428 KPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVD 1487
Query: 647 SATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSF 706
TD I+Q IR+EF++ T++T+AHR+ TV+DSD ++VL G + E+D PSKL+ +S
Sbjct: 1488 METDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSI 1547
Query: 707 SKLVAEYWSSCRK 719
++S C K
Sbjct: 1548 ------FYSLCEK 1554
Score = 66.2 bits (160), Expect = 3e-10
Identities = 86/368 (23%), Positives = 149/368 (40%), Gaps = 51/368 (13%)
Query: 401 LLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVERIKQFIHIPAEPP 460
L L LSP V SLS LN A + + +S+ER+K F+
Sbjct: 538 LFSLFSDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDD 597
Query: 461 AIVDNNRPPSS---------------WPSKGKI-------DLQGLEVRYRPNAPLVLKGI 498
+ ++ P + W SK + +L+ E ++ + LK I
Sbjct: 598 SFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNI 657
Query: 499 T-CTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKD-LRMKLS 556
K G V VVGR G+GKST + A+ G C G +D + KL
Sbjct: 658 DHFEAKRGDLVCVVGRVGAGKSTFLKAIL-------------GQLPCMSGSRDSIPPKLI 704
Query: 557 I-------IPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVS 609
I QE + S+R N+ + D ++ CQL + LP ++ V
Sbjct: 705 IRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVG 764
Query: 610 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDS-ATDAILQRIIRQE---FEECT 665
++G + S GQ+ L R + R I +LD+ +++D+ + I++ ++ + + T
Sbjct: 765 EKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKT 824
Query: 666 VITVAHRVPTVIDSDMVMVLSYGKLVE---YDEPSKLMDTNSSFSKLVAEYWSSCRKNSL 722
+I + V + S M+ L G++VE Y++ + S KL+ E+ S +
Sbjct: 825 IILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNE 884
Query: 723 PYISKKHQ 730
+ +H+
Sbjct: 885 SDVQTEHR 892
>ACC9_MOUSE (P70170) Sulfonylurea receptor 2
Length = 1546
Score = 396 bits (1017), Expect = e-109
Identities = 257/744 (34%), Positives = 411/744 (54%), Gaps = 44/744 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRD--KTVILVTH 58
+SGGQ+QRI +ARA+Y + +I LDDPFSA+D H + L + ++ L+D +TV+LVTH
Sbjct: 809 LSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTH 868
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLNQNSEVLSNPQ 115
++++L+ D I+ DG V++ G+ LK ++ + H T+ +N+ + L
Sbjct: 869 KLQYLTHADWIIAMKDGSVLREGT----LKDIQTKDVELYEHWKTL--MNRQDQELEKDM 922
Query: 116 DSHGFYLTKNQSEGEISSIQGSIGAQLTQEEE--------------KVIGNVGWKPLWDY 161
++ L + + S + + EEE ++ + WK W Y
Sbjct: 923 EADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWKTCWWY 982
Query: 162 INYSNGTLMSCLVILGQCCFLALQTSSNFWLAT-----AIEIPKVTDTTL-IGVYALLSI 215
+ S G + L+I + ++ + ++WLAT +I P D T + +++L
Sbjct: 983 LT-SGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINHPGKADQTFYVAGFSILCG 1041
Query: 216 SSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILD 268
+ V S +GL A+ + I P+ FFD+TP S+D +I+D
Sbjct: 1042 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1101
Query: 269 FDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRIN 328
IP +L + + L I +I+ T L+ P VA FIQKY++ +++L ++
Sbjct: 1102 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELD 1161
Query: 329 GTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIE 388
+T+ P++ +ET+ G+ T+RAF RF + L+L DT+ + + A WL +R +
Sbjct: 1162 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTD 1221
Query: 389 ALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVER 448
L V+TA++ I + G VGL L YALT+ + R ++L + +V++
Sbjct: 1222 YLGACIVLTASIASI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1278
Query: 449 IKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSR 507
+ F+ + +E +D ++ P WP +G+I + L VRY N VLK + K G +
Sbjct: 1279 VNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQK 1338
Query: 508 VGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKG 567
VG+ GRTGSGKS+L A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF G
Sbjct: 1339 VGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSG 1398
Query: 568 SIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGR 627
SIR NLDP +DD +W+A+E QLK + LP LD++V++ G N+S+GQRQLFCL R
Sbjct: 1399 SIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLAR 1458
Query: 628 VLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSY 687
++++ IL++DEATASID AT+ ILQ+++ F + TV+T+AHRV +++D+ +V+V S
Sbjct: 1459 AFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIVDAGLVLVFSE 1518
Query: 688 GKLVEYDE-PSKLMDTNSSFSKLV 710
G LVE D P+ L N FS LV
Sbjct: 1519 GILVECDTGPNLLQHKNGLFSTLV 1542
Score = 68.2 bits (165), Expect = 8e-11
Identities = 50/205 (24%), Positives = 100/205 (48%), Gaps = 9/205 (4%)
Query: 495 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 554
L I G +VG+ G GKS+L+ A+ ++ G + + +N + R +
Sbjct: 685 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSR 744
Query: 555 ----LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVS 609
++ Q+P L ++ N+ G + + +KAV + C L+ I LP + +
Sbjct: 745 SRYSVAYAAQKPWLLNATVEENIT-FGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIG 803
Query: 610 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDAILQRIIRQ--EFEECTV 666
+ G N S GQRQ C+ R L + I+ LD+ +++D +D ++Q I + + ++ TV
Sbjct: 804 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTV 863
Query: 667 ITVAHRVPTVIDSDMVMVLSYGKLV 691
+ V H++ + +D ++ + G ++
Sbjct: 864 VLVTHKLQYLTHADWIIAMKDGSVL 888
>ACC9_RAT (Q63563) Sulfonylurea receptor 2
Length = 1545
Score = 395 bits (1016), Expect = e-109
Identities = 258/744 (34%), Positives = 411/744 (54%), Gaps = 44/744 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRD--KTVILVTH 58
+SGGQ+QRI +ARA+Y + +I LDDPFSA+D H + L + ++ L+D +TV+LVTH
Sbjct: 808 LSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTH 867
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLNQNSEVLSNPQ 115
++++L+ D I+ DG V++ G+ LK ++ + H T+ +N+ + L
Sbjct: 868 KLQYLTHADWIIAMKDGSVLREGT----LKDIQTKDVELYEHWKTL--MNRQDQELEKDM 921
Query: 116 DSHGFYLTKNQSEGEISSIQGSIGAQLTQEEE--------------KVIGNVGWKPLWDY 161
++ L + + S + + EEE ++ + WK W Y
Sbjct: 922 EADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWY 981
Query: 162 INYSNGTLMSCLVILGQCCFLALQTSSNFWLAT-----AIEIPKVTDTTL-IGVYALLSI 215
+ S G + L+I + ++ + ++WLAT +I P D T + +++L
Sbjct: 982 LT-SGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQTFYVAGFSILCG 1040
Query: 216 SSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILD 268
+ V S +GL A+ + I P+ FFD+TP S+D +I+D
Sbjct: 1041 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1100
Query: 269 FDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRIN 328
IP +L + + L I +I+ T LI P VA FIQKY++ +++L ++
Sbjct: 1101 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELD 1160
Query: 329 GTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIE 388
+T+ P++ +ET+ G+ T+RAF RF + L+L DT+ + + A WL +R +
Sbjct: 1161 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTD 1220
Query: 389 ALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVER 448
L V+TA++ I + G VGL L YALT+ + R ++L + +V++
Sbjct: 1221 YLGACIVLTASIASI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1277
Query: 449 IKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSR 507
+ F+ + +E +D ++ P WP +G+I + L VRY N VLK + K G +
Sbjct: 1278 VNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQK 1337
Query: 508 VGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKG 567
VG+ GRTGSGKS+L A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF G
Sbjct: 1338 VGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSG 1397
Query: 568 SIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGR 627
SIR NLDP +DD +W+A+E QLK + LP LD++V++ G N+S+GQRQLFCL R
Sbjct: 1398 SIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLAR 1457
Query: 628 VLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSY 687
++++ IL++DEATASID AT+ ILQ+++ F + TV+T+AHRV +++D+ +V+V S
Sbjct: 1458 AFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSE 1517
Query: 688 GKLVEYDE-PSKLMDTNSSFSKLV 710
G LVE D P+ L N FS LV
Sbjct: 1518 GILVECDTGPNLLQHKNGLFSTLV 1541
Score = 68.6 bits (166), Expect = 6e-11
Identities = 50/205 (24%), Positives = 100/205 (48%), Gaps = 9/205 (4%)
Query: 495 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 554
L I G +VG+ G GKS+L+ A+ ++ G + + +N + R +
Sbjct: 684 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSR 743
Query: 555 ----LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVS 609
++ Q+P L ++ N+ G + + +KAV + C L+ I LP + +
Sbjct: 744 SRYSVAYAAQKPWLLNATVEENIT-FGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIG 802
Query: 610 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDAILQRIIRQ--EFEECTV 666
+ G N S GQRQ C+ R L + I+ LD+ +++D +D ++Q I + + ++ TV
Sbjct: 803 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTV 862
Query: 667 ITVAHRVPTVIDSDMVMVLSYGKLV 691
+ V H++ + +D ++ + G ++
Sbjct: 863 VLVTHKLQYLTHADWIIAMKDGSVL 887
>ACC8_RAT (Q09429) Sulfonylurea receptor 1
Length = 1581
Score = 393 bits (1009), Expect = e-108
Identities = 261/755 (34%), Positives = 404/755 (52%), Gaps = 62/755 (8%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRD--KTVILVTH 58
+SGGQ+QRI +ARA+Y ++ LDDPFSA+D H + L ++ LRD +TV+LVTH
Sbjct: 829 LSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTH 888
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLNQNSE---VLS 112
++++L D I+ DG + + G+ ++ +S L K +N +Q E V+
Sbjct: 889 KLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQ---LFEHWKTLMNRQDQELEKETVME 945
Query: 113 N--PQDSHGFYLTKNQSEGEISSIQGSIGAQLTQEEEKVIGNV-------GWKPLWDYIN 163
P+ S G + +G + EE+ + +V W+ Y++
Sbjct: 946 RKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLS 1005
Query: 164 YSNGTLMSCLVILGQCCFLALQTSSNFWLATAIEIPKVTDTTLI---------------- 207
S G L+ L++ Q + + ++WLA K TD+ L+
Sbjct: 1006 -SAGILLLSLLVFSQLLKHMVLVAIDYWLA------KWTDSALVLSPAARNCSLSQECAL 1058
Query: 208 --GVYAL----LSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA- 260
VYA+ L + V S GLK + S I APM FF++TP
Sbjct: 1059 DQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLG 1118
Query: 261 ------SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQ 314
SSD + +D IP +L C++ + + + VI+ VT L+ +P V FIQ
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAVVCYFIQ 1178
Query: 315 KYYQATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTD--ASL 372
KY++ +R+L +++ TT+ P+++ AET G+ T+RAF RF + L+ D++ ASL
Sbjct: 1179 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASL 1238
Query: 373 FFHSNVAMEWLVLRIEALLNLTVITAALLLILLP-QRYLSPGRVGLSLSYALTLNGAQIF 431
F A WL +R+E + V+ AA I R LS G VGL L+YAL ++ +
Sbjct: 1239 FL--TAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNW 1296
Query: 432 WTRWFSNLSNYIISVERIKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQGLEVRYRPN 490
R +++ + +V+RI + AE ++ + P +WP +GKI +Q L VRY +
Sbjct: 1297 MVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSS 1356
Query: 491 APLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKD 550
VLK + G ++G+ GRTGSGKS+ A FR+V+ G I+IDGI+I + L
Sbjct: 1357 LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHT 1416
Query: 551 LRMKLSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSD 610
LR +LSII Q+P LF G+IR NLDP SD +W+A+E QLK + LP LD+ +++
Sbjct: 1417 LRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITE 1476
Query: 611 EGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVA 670
G N+S GQRQLFCL R +++ I ++DEATASID AT+ ILQ+++ F + TV+T+A
Sbjct: 1477 GGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIA 1536
Query: 671 HRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 705
HRV T++ +D+VMVL G ++E+D+P KL+ S
Sbjct: 1537 HRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDS 1571
Score = 57.8 bits (138), Expect = 1e-07
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 21/247 (8%)
Query: 487 YRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSM 546
+ P+ L IT G +VG+ G GKS+L+ A ++ G + + S
Sbjct: 687 WTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSE 746
Query: 547 GL------------KDLRMK--LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQ 592
G D R + ++ Q+P L ++ N+ ++ +E C
Sbjct: 747 GEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACS 806
Query: 593 LKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDA 651
L+ I LP + + + G N S GQRQ + R L + ++ LD+ +++D +D
Sbjct: 807 LQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDH 866
Query: 652 ILQRIIRQ--EFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMDTNSSFSKL 709
++Q I + ++ TV+ V H++ + +D ++ + G + L D S +L
Sbjct: 867 LMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI---QREGTLKDFQRSECQL 923
Query: 710 VAEYWSS 716
E+W +
Sbjct: 924 F-EHWKT 929
>ACC8_HUMAN (Q09428) Sulfonylurea receptor 1
Length = 1580
Score = 391 bits (1004), Expect = e-108
Identities = 255/751 (33%), Positives = 401/751 (52%), Gaps = 54/751 (7%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRD--KTVILVTH 58
+SGGQ+QRI +ARA+Y A++ LDDPFSA+D H + L ++ LRD +TV+LVTH
Sbjct: 828 LSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTH 887
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAF-----------ELLVSAHKVTINDL 104
++++L D I+ DG + + G+ ++ +S + + VT
Sbjct: 888 KLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKA 947
Query: 105 NQNSEVLSNPQDSHGFYLTKNQSEGEI---SSIQGSIGAQLTQEEEKVIGNVGWKPLWDY 161
+ + LS S L + E E S ++ + L Q E + W+ Y
Sbjct: 948 TEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAE-----IPWRACAKY 1002
Query: 162 INYSNGTLMSCLVILGQCCFLALQTSSNFWLA----TAIEIPKVT------------DTT 205
++ S G L+ L++ Q + + ++WLA +A+ + T
Sbjct: 1003 LS-SAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTV 1061
Query: 206 LIGVYALLSISSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA----- 260
V+ +L V S GLK + S I APM FF++TP
Sbjct: 1062 YAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1121
Query: 261 --SSDLSILDFDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQ 318
SSD + +D IP +L C++ + + + VI+ VT L+ +P + FIQKY++
Sbjct: 1122 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1181
Query: 319 ATARELIRINGTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTD--ASLFFHS 376
+R+L +++ TT+ P+++ AET G+ T+RAF RF + L+ D++ ASLF
Sbjct: 1182 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFL-- 1239
Query: 377 NVAMEWLVLRIEALLNLTVITAALLLILLP-QRYLSPGRVGLSLSYALTLNGAQIFWTRW 435
A WL +R+E + V+ AA+ I R LS G VGL L+YAL ++ + R
Sbjct: 1240 TAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRN 1299
Query: 436 FSNLSNYIISVERIKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLV 494
+++ + +V+RI + AE ++ + P +WP +GKI +Q L VRY + V
Sbjct: 1300 LADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPV 1359
Query: 495 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 554
LK + G ++G+ GRTGSGKS+ A FR+V+ G I+IDGI+I + L LR +
Sbjct: 1360 LKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSR 1419
Query: 555 LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGN 614
LSII Q+P LF G+IR NLDP SD +W+A+E QLK + LP LD+ +++ G N
Sbjct: 1420 LSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGEN 1479
Query: 615 WSLGQRQLFCLGRVLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVP 674
+S GQRQLFCL R +++ I ++DEATASID AT+ ILQ+++ F + TV+T+AHRV
Sbjct: 1480 FSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVH 1539
Query: 675 TVIDSDMVMVLSYGKLVEYDEPSKLMDTNSS 705
T++ +D+V+VL G ++E+D+P KL+ S
Sbjct: 1540 TILSADLVIVLKRGAILEFDKPEKLLSRKDS 1570
Score = 60.5 bits (145), Expect = 2e-08
Identities = 55/255 (21%), Positives = 109/255 (42%), Gaps = 20/255 (7%)
Query: 478 IDLQGLEVRYRPNAPLVLKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIL 537
+ + G + P+ L IT G +VG+ G GKS+L+ A ++ G +
Sbjct: 678 VQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVF 737
Query: 538 IDGINICSMGLK-----------DLRMK--LSIIPQEPTLFKGSIRTNLDPLGLYSDDEI 584
+ +G D+R + ++ Q+P L ++ N+ ++
Sbjct: 738 WSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRY 797
Query: 585 WKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATAS 644
+E C L+ I LP + + + G N S GQRQ + R L + ++ LD+ ++
Sbjct: 798 KMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSA 857
Query: 645 ID-SATDAILQRIIRQ--EFEECTVITVAHRVPTVIDSDMVMVLSYGKLVEYDEPSKLMD 701
+D +D ++Q I + ++ TV+ V H++ + +D ++ + G + L D
Sbjct: 858 LDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI---QREGTLKD 914
Query: 702 TNSSFSKLVAEYWSS 716
S +L E+W +
Sbjct: 915 FQRSECQLF-EHWKT 928
>ACC9_RABIT (P82451) Sulfonylurea receptor 2
Length = 1549
Score = 390 bits (1003), Expect = e-108
Identities = 254/744 (34%), Positives = 407/744 (54%), Gaps = 44/744 (5%)
Query: 1 MSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCVMTALRD--KTVILVTH 58
+SGGQ +RI +ARA+Y + +I LDDPFSA+D H + L + ++ L+D +T++LVTH
Sbjct: 812 LSGGQTERICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTH 871
Query: 59 QVEFLSEVDTIL---DGKVIQSGSYENLLKSGTAFELLVSAHKVTINDLNQNSEVLSNPQ 115
++++L+ D I+ DG V++ G+ LK ++ + H T+ +N+ + L
Sbjct: 872 KLQYLTHADWIIAMKDGSVLREGT----LKDIQTKDVELYEHWKTL--MNRQDQELEKDM 925
Query: 116 DSHGFYLTKNQSEGEISSIQGSIGAQLTQEEE--------------KVIGNVGWKPLWDY 161
++ L + + S + + EEE ++ + WK W Y
Sbjct: 926 EADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRY 985
Query: 162 INYSNGTLMSCLVILGQCCFLALQTSSNFWLATAIE------IPKVTDTTLIGVYALLSI 215
+ S G + L+I + ++ + ++WLAT K T + +++L
Sbjct: 986 LT-SGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1044
Query: 216 SSTSFVYVRSYFAALLGLKASTAFFSSFTTSIFNAPMLFFDSTPA-------SSDLSILD 268
+ V S +GL A+ + I P+ FFD+TP S+D +I+D
Sbjct: 1045 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1104
Query: 269 FDIPYSLTCVAIVAIEVLVMIFVIASVTWQVLIVAVPAMVALIFIQKYYQATARELIRIN 328
IP +L + + L I +I+ T L+ VP VA FIQKY++ +++L ++
Sbjct: 1105 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELD 1164
Query: 329 GTTKAPVMNFAAETSLGVVTVRAFNMVDRFFKNYLKLVDTDASLFFHSNVAMEWLVLRIE 388
+T+ P++ +ET+ G+ T+RAF RF + L+L DT+ + + A WL +R +
Sbjct: 1165 DSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNIAYLFLSAANRWLEVRTD 1224
Query: 389 ALLNLTVITAALLLILLPQRYLSPGRVGLSLSYALTLNGAQIFWTRWFSNLSNYIISVER 448
L V+TA++ I + G VGL L YALT+ + R ++L + +V++
Sbjct: 1225 YLGACIVLTASIASI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281
Query: 449 IKQFIHIPAEP-PAIVDNNRPPSSWPSKGKIDLQGLEVRYRPNAPLVLKGITCTFKGGSR 507
+ F+ + +E +D ++ P WP +G+I + L VRY N VLK + K G +
Sbjct: 1282 VNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQK 1341
Query: 508 VGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMKLSIIPQEPTLFKG 567
VG+ GRTGSGKS+L A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF G
Sbjct: 1342 VGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSG 1401
Query: 568 SIRTNLDPLGLYSDDEIWKAVEKCQLKETISKLPSLLDSSVSDEGGNWSLGQRQLFCLGR 627
SIR NLDP +DD +W+A+E QLK + L LD+ V++ G N+S+GQRQLFCL R
Sbjct: 1402 SIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLSGGLDAVVTEGGENFSVGQRQLFCLAR 1461
Query: 628 VLLKRNRILVLDEATASIDSATDAILQRIIRQEFEECTVITVAHRVPTVIDSDMVMVLSY 687
++++ IL++DEATASID AT+ ILQ+++ F + TV+T+AHRV +++D+D+V+V S
Sbjct: 1462 AFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIVDADLVLVFSE 1521
Query: 688 GKLVEYDE-PSKLMDTNSSFSKLV 710
G LVE D P+ L N FS LV
Sbjct: 1522 GILVECDTGPNLLTHKNGLFSTLV 1545
Score = 62.0 bits (149), Expect = 5e-09
Identities = 47/205 (22%), Positives = 98/205 (46%), Gaps = 9/205 (4%)
Query: 495 LKGITCTFKGGSRVGVVGRTGSGKSTLISALFRLVEPSRGDILIDGINICSMGLKDLRMK 554
L I G +VG+ G GKS+L+ A+ ++ G + +N + R +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLDGKVHWSNVNESEPSFEATRSR 747
Query: 555 ----LSIIPQEPTLFKGSIRTNLDPLGLYSDDEIWKAV-EKCQLKETISKLPSLLDSSVS 609
++ Q+P L ++ N+ G + + +KAV + C L+ I LP + +
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENIT-FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 610 DEGGNWSLGQRQLFCLGRVLLKRNRILVLDEATASID-SATDAILQRIIRQ--EFEECTV 666
+ G N S GQ + C+ R L + I+ LD+ +++D +D ++Q I + + ++ T+
Sbjct: 807 ERGINLSGGQTERICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 667 ITVAHRVPTVIDSDMVMVLSYGKLV 691
+ V H++ + +D ++ + G ++
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVL 891
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.136 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,376,860
Number of Sequences: 164201
Number of extensions: 3290786
Number of successful extensions: 13563
Number of sequences better than 10.0: 970
Number of HSP's better than 10.0 without gapping: 836
Number of HSP's successfully gapped in prelim test: 134
Number of HSP's that attempted gapping in prelim test: 10233
Number of HSP's gapped (non-prelim): 2428
length of query: 730
length of database: 59,974,054
effective HSP length: 118
effective length of query: 612
effective length of database: 40,598,336
effective search space: 24846181632
effective search space used: 24846181632
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Medicago: description of AC148395.15