BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC147964.8 + phase: 0 
         (992 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

VP39_MOUSE (Q8R5L3) Vam6/Vps39-like protein (Vps39 protein)           279  3e-74
VP39_HUMAN (Q96JC1) Vam6/Vps39-like protein (hVam6p)                  278  7e-74
VP39_YEAST (Q07468) Vacuolar assembly protein VPS39 (Vacuolar mo...    70  4e-11
ROM2_YEAST (P51862) RHO1 GDP-GTP exchange protein 2                    43  0.004
VP41_YEAST (P38959) Vacuolar assembly protein VPS41 (Vacuolar mo...    39  0.053
VP41_CAEEL (Q19954) Vacuolar assembly protein VPS41 homolog            39  0.090
GPT2_YEAST (P36148) Glycerol-3-phosphate O-acyltransferase 2 (EC...    37  0.34
MLH1_SCHPO (Q9P7W6) Putative MUTL protein homolog 1 (DNA mismatc...    36  0.45
KNTC_HUMAN (P50748) Kinetochore-associated protein 1 (Rough deal...    36  0.58
TNIK_MOUSE (P83510) Traf2 and NCK interacting kinase (EC 2.7.1.3...    35  0.99
TNIK_HUMAN (Q9UKE5) TRAF2 and NCK interacting kinase (EC 2.7.1.37)     35  0.99
ROM1_YEAST (P53046) RHO1 GDP-GTP exchange protein 1 (Protein kin...    35  0.99
PKND_CHLMU (Q9PK92) Serine/threonine-protein kinase pknD (EC 2.7...    35  1.3
NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC 2.7...    34  1.7
RECN_AQUAE (O66834) DNA repair protein recN (Recombination prote...    34  2.2
G59F_DROME (Q9W1N5) Putative gustatory receptor 59f                    33  2.9
Y111_ENCCU (Q8STB5) Hypothetical protein ECU01_0110/ECU01_1500/E...    33  3.8
SL2B_HUMAN (Q8NEV8) Slp homolog lacking C2 domains-b (Exophilin 5)     33  3.8
MI15_CAEEL (Q23356) Serine/threonine-protein kinase mig-15 (EC 2...    33  3.8
MAD1_DEBHA (Q6BSY1) Spindle assembly checkpoint component MAD1 (...    33  3.8

>VP39_MOUSE (Q8R5L3) Vam6/Vps39-like protein (Vps39 protein)
          Length = 886

 Score =  279 bits (713), Expect = 3e-74
 Identities = 236/822 (28%), Positives = 392/822 (46%), Gaps = 113/822 (13%)

Query: 2   VHTAYDSFELLTNSTSKIESIESYGSKLLLGCSNGSLLVYAPEHSV-------PAPEEMR 54
           +H A++   +L     +I+ + ++   LL+G   G LL+Y     V       P      
Sbjct: 1   MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60

Query: 55  KEAYVLERNVNGFAKKAVVSLQVVESREFLLSLSES-IAFHKLPTFETIAVITKAKGANA 113
           +    LE++   F+KK +  + VV   + L+SL E+ I  H L TF+ I  ++KAKGA+ 
Sbjct: 61  RFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASL 119

Query: 114 FCWD-------EHRGFLCFARQKRVCI-FRRDGGRGFVEVK-DFGVLDVVKSMSWCGENI 164
           F  D       E    +C A +K++ + F +D  R F E++ DF V DV KSM+WC  +I
Sbjct: 120 FTCDLQHTETGEEVLRMCVAVRKKLQLYFWKD--REFHELQGDFSVPDVPKSMAWCENSI 177

Query: 165 CLGIRKAYVILNATS-GSISEVFTSGRLAPPLVVSLPSGELLLGKDNIGVIVDQNGKLRP 223
           C+G ++ Y ++     GSI E+F +G+   PLV  L  G++ +G+D++ V++++ G    
Sbjct: 178 CVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQ 237

Query: 224 EGRICWSEAPTEVVIQNPYALALLPRFVEIRSLRGPYPLIQTIVFRNVRHLRQSNNSVI- 282
           +  + W++ P  +  Q PY +A+LPR+VEIR+L  P  L+Q+I  +  R +    +++I 
Sbjct: 238 KCALNWTDIPVAMEHQPPYIVAVLPRYVEIRTLE-PRLLVQSIELQRPRFITSGGSNIIY 296

Query: 283 IALENSIHCLFPVPLGAQIVQLTAAGNFEEALSLCKLLPPEDSNLRAAKEDSIH---IRY 339
           +A  + +  L PVP+  QI QL     FE AL L ++    DS     K+  IH     Y
Sbjct: 297 VASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSE----KQQQIHHIKNLY 352

Query: 340 AHYLFDNGSYEESMEHFLASQVDITYVLSLYTSIILPKTTIVHDSDKLDIFGDPLHLSRG 399
           A  LF    ++ESM+ F     D T+V+ LY   +LP      D  K   + +PL    G
Sbjct: 353 AFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPD-LLPT-----DYRKQLQYPNPLPTLSG 406

Query: 400 SSMSDDMEPSSASNMSELDDNAELESKKMSHNMLMALIKFLHKKRHSIIEKATAEGTEEV 459
                                AELE         +ALI +L +KR  +++K         
Sbjct: 407 ---------------------AELEKAH------LALIDYLTQKRSQLVKKLN------- 432

Query: 460 VFDAVGNNFESYNSNRFKKINKRHGSIPVSSEAREMASILDTALLQAMLLTGQPSMAENL 519
                       +S+     +      P     +++  I+DT LL+  L T    +A  L
Sbjct: 433 ------------DSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480

Query: 520 LRVLNYCDLKICEEILQEGSYHVSLVELYKCNSMHREALEIINKSVKESESSQSKIAHRF 579
               N+C ++  E +L++   +  L+ LY+   +H +AL+++   V +S+ + S +    
Sbjct: 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVL---VDQSKKANSPLKGH- 536

Query: 580 KPEAIIEYLKPLCELDTTLVLEYSMLVLESCPTQTIELFLSG-----NIPADMVNLYLKQ 634
             E  ++YL+ L   +  L+  YS+ VL   P   +++F        ++P D V  +L +
Sbjct: 537 --ERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIE 594

Query: 635 HAPNLQATYLELVLSMNEGAVSGTLQNEMVHLYLSEVLDWHADL------------SSEQ 682
           +   L   YLE ++ + E        N ++ LY  +V     D             + E+
Sbjct: 595 NFKALAIPYLEHIIHVWE-ETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEE 653

Query: 683 KWDEKVYSPKRKKLLSALESISGYNPEALLKLLPSDALYEERAILLGKMNQHELALSLYV 742
             +   Y   R+KLL  LE  S Y+P  L+   P D L EERA+LLG+M +HE AL +YV
Sbjct: 654 GGELGEY---RQKLLMFLEISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYV 710

Query: 743 HKLHVPELALSYCDHVYESAHKSSVKSLSNIYLMLLQIYLNP 784
           H L   ++A  YC   Y+   + +     ++YL LL++YL+P
Sbjct: 711 HVLKDTKMAKEYCHKHYDQNKEGN----KDVYLSLLRMYLSP 748


>VP39_HUMAN (Q96JC1) Vam6/Vps39-like protein (hVam6p)
          Length = 886

 Score =  278 bits (710), Expect = 7e-74
 Identities = 238/819 (29%), Positives = 394/819 (48%), Gaps = 107/819 (13%)

Query: 2   VHTAYDSFELLTNSTSKIESIESYGSKLLLGCSNGSLLVYAPEHSV-------PAPEEMR 54
           +H A++   +L     +I+ + ++   LL+G   G LL+Y     V       P      
Sbjct: 1   MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60

Query: 55  KEAYVLERNVNGFAKKAVVSLQVVESREFLLSLSES-IAFHKLPTFETIAVITKAKGANA 113
           +    LE++   F+KK +  + VV   + L+SL E+ I  H L TF+ I  ++KAKGA+ 
Sbjct: 61  RFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASL 119

Query: 114 FCWD-------EHRGFLCFARQKRVCI-FRRDGGRGFVEVK-DFGVLDVVKSMSWCGENI 164
           F  D       E    +C A +K++ + F +D  R F E++ DF V DV KSM+WC  +I
Sbjct: 120 FTCDLQHTETGEEVLQMCVAVKKKLQLYFWKD--REFHELQGDFSVPDVPKSMAWCENSI 177

Query: 165 CLGIRKAYVILNATS-GSISEVFTSGRLAPPLVVSLPSGELLLGKDNIGVIVDQNGKLRP 223
           C+G ++ Y ++     GSI E+F +G+   PLV  L  G++ +G+D++ V++++ G    
Sbjct: 178 CVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQ 237

Query: 224 EGRICWSEAPTEVVIQNPYALALLPRFVEIRSLRGPYPLIQTIVFRNVRHLRQSNNSVI- 282
           +  + W++ P  +  Q PY +A+LPR+VEIR+   P  L+Q+I  +  R +    +++I 
Sbjct: 238 KCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFE-PRLLVQSIELQRPRFITSGGSNIIY 296

Query: 283 IALENSIHCLFPVPLGAQIVQLTAAGNFEEALSLCKLLPPEDSNLRAAKEDSIHI---RY 339
           +A  + +  L PVP+  QI QL     FE AL L ++    DS     K+  IH     Y
Sbjct: 297 VASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSE----KQQQIHHIKNLY 352

Query: 340 AHYLFDNGSYEESMEHFLASQVDITYVLSLYTSIILPKTTIVHDSDKLDIFGDPLHLSRG 399
           A  LF    ++ESM+ F     D T+V+ LY  + LP      D  K   + +PL +  G
Sbjct: 353 AFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDL-LPT-----DYRKQLQYPNPLPVLSG 406

Query: 400 SSMSDDMEPSSASNMSELDDNAELESKKMSHNMLMALIKFLHKKRHSIIEKATAEGTEEV 459
                                AELE   +      ALI +L +KR  +++K         
Sbjct: 407 ---------------------AELEKAHL------ALIDYLTQKRSQLVKKLN------- 432

Query: 460 VFDAVGNNFESYNSNRFKKINKRHGSIPVSSEAREMASILDTALLQAMLLTGQPSMAENL 519
                       +S+     +      P     +++  I+DT LL+  L T    +A  L
Sbjct: 433 ------------DSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480

Query: 520 LRVLNYCDLKICEEILQEGSYHVSLVELYKCNSMHREALEIINKSVKESESSQSKIAHRF 579
               N+C ++  E +L++   +  L+ LY+   +H +AL+++   V +S+ + S +    
Sbjct: 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVL---VDQSKKANSPLKGH- 536

Query: 580 KPEAIIEYLKPLCELDTTLVLEYSMLVLESCPTQTIELFLSG-----NIPADMVNLYLKQ 634
             E  ++YL+ L   +  L+  YS+ VL   P   +++F        ++P D V  +L +
Sbjct: 537 --ERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIE 594

Query: 635 HAPNLQATYLELVLSMNEGAVSGTLQNEMVHLYLSEV--------LDWHADLSSEQKWDE 686
           +   L   YLE ++ + E   S    N ++ LY  +V        L + A  +     +E
Sbjct: 595 NFKGLAIPYLEHIIHVWEETGS-RFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEE 653

Query: 687 K-VYSPKRKKLLSALESISGYNPEALLKLLPSDALYEERAILLGKMNQHELALSLYVHKL 745
           +      R+KLL  LE  S Y+P  L+   P D L EERA+LLG+M +HE AL +YVH L
Sbjct: 654 EGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHIL 713

Query: 746 HVPELALSYCDHVYESAHKSSVKSLSNIYLMLLQIYLNP 784
               +A  YC H +   +K   K   ++YL LL++YL+P
Sbjct: 714 KDTRMAEEYC-HKHYDRNKDGNK---DVYLSLLRMYLSP 748



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 35/114 (30%), Positives = 68/114 (58%), Gaps = 1/114 (0%)

Query: 862 LDEALDLLSRRWDRINGAQALKLLPKETKLQNLLPILGPLVRKSSEMYRNCSVVRSLRQS 921
           L  AL +L     +++  +AL LLP  T++ ++   L  ++ ++++  R   V+++L  +
Sbjct: 768 LQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHA 827

Query: 922 ENLQVKDELYNKRKAVIKISDDNMCSLCHKKIGTSVFAVYPNGKTLVHFVCFRD 975
           E L+V++E    ++    I+++ +C +C KKIG S FA YPNG  +VH+ C ++
Sbjct: 828 EFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNG-VVVHYFCSKE 880


>VP39_YEAST (Q07468) Vacuolar assembly protein VPS39 (Vacuolar
           morphogenesis protein VAM6)
          Length = 1049

 Score = 69.7 bits (169), Expect = 4e-11
 Identities = 81/322 (25%), Positives = 131/322 (40%), Gaps = 48/322 (14%)

Query: 495 MASILDTALLQAMLLTGQPSMAENLLRVLNYCDLKICEEILQEGSYHVSLVELYKCNSMH 554
           M +++DT L +  L    P M    +RV N+CD  +    L+       L++ Y     H
Sbjct: 599 MLTLIDTVLFKCYLYYNPP-MVGPFIRVENHCDSHVIVTELKIRHMFKDLIDFYYKRGNH 657

Query: 555 REALEIINKSVKESESSQSKIAHRFKPE-----AIIEYLKPLCELDTTLVLEYSMLVLES 609
            EAL+ +   V E E+  +    R K +      +I YLK L      ++  Y+  +L  
Sbjct: 658 EEALKFLTDLVDELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLLNR 717

Query: 610 CPTQTIELFLSGNIPADM----------VNLYLKQHAPNLQATYLELVLSMNEGAVSGTL 659
               +I+  LS     D           V  Y+K+    L   YLE  +S      +  L
Sbjct: 718 -HNDSIKEILSSIFFYDSQACSSRDHLKVYGYIKKFDKLLAIQYLEFAIS------TFRL 770

Query: 660 QNEMVHLYLSEVLDWHADLSSEQKWDEKVYSPKRKKLLSALESISGYNPEALLKLLP--- 716
           +   +H  L ++   + D+ S            R KL S LE+ S Y P  +LKLL    
Sbjct: 771 EGNKLHTVLIKLYLENLDIPST-----------RIKLKSLLETTSVYEPRTILKLLNDAI 819

Query: 717 ---SDALYEE--------RAILLGKMNQHELALSLYVHKLHVPELALSYCDHVYESAHKS 765
              SD L           +   L K+  H+ A+ + + ++   + A SYC+ VY+S    
Sbjct: 820 ESGSDQLPTNQLNFVKYLKIFPLSKLENHKEAVHILLDEIDDYKAATSYCNDVYQSDSTK 879

Query: 766 SVKSLSNIYLMLLQIYLNPRRT 787
             + L  +Y  L+ IY + R +
Sbjct: 880 GEELLLYLYSKLVSIYDSNRNS 901



 Score = 37.0 bits (84), Expect = 0.26
 Identities = 25/112 (22%), Positives = 54/112 (47%), Gaps = 5/112 (4%)

Query: 866  LDLLSRRWDRINGAQALKLLPKETKLQNLLPILGPLVRKSSEMYRNCSVVRSLRQSENLQ 925
            L+ L     ++N A+  K LP++  L ++  ++  L++K +       + ++L Q E + 
Sbjct: 905  LNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVELVA 964

Query: 926  VKDELYNKRKAVIKISDDNMCSLCHKKI---GTSVFAVYP-NGKTLV-HFVC 972
               +L  +  +   +SD + C +C K I   GT   + +   G+ ++ H+ C
Sbjct: 965  TTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNC 1016


>ROM2_YEAST (P51862) RHO1 GDP-GTP exchange protein 2
          Length = 1356

 Score = 43.1 bits (100), Expect = 0.004
 Identities = 36/142 (25%), Positives = 59/142 (41%), Gaps = 11/142 (7%)

Query: 156  SMSWCGENICLGIRKAYVIL----NATSGSISEVFTSGRLA-----PPLVVSLPSGELLL 206
            S+S+   N+C+G +K + I+    NA    +    TS   A      P+ +       LL
Sbjct: 1202 SISFLKANLCIGCKKGFQIVSISQNAHESLLDPADTSLEFALRDTLKPMAIYRVGNMFLL 1261

Query: 207  GKDNIGVIVDQNGKLRPEGRIC-WSEAPTEVVIQNPYALALLPRFVEIRSLRGPYPLIQT 265
                    V+  G  + E  I  W   P +  I  PY LA    F+EIR +     LI+ 
Sbjct: 1262 CYTEFAFFVNNQGWRKKESHIIHWEGEPQKFAIWYPYILAFDSNFIEIRKIE-TGELIRC 1320

Query: 266  IVFRNVRHLRQSNNSVIIALEN 287
            ++   +R L+ S   ++   E+
Sbjct: 1321 VLADKIRLLQTSTQEILYCYED 1342


>VP41_YEAST (P38959) Vacuolar assembly protein VPS41 (Vacuolar
           morphogenesis protein VAM2)
          Length = 992

 Score = 39.3 bits (90), Expect = 0.053
 Identities = 47/231 (20%), Positives = 99/231 (42%), Gaps = 33/231 (14%)

Query: 536 QEGS---YHVSLVELYKCNSMHREALEIINKSVKESESSQSKIAHRFKP--EAIIEYLKP 590
           +EGS   Y   LV LY   + + +A+  + K+      +  KI +      + I++ +  
Sbjct: 666 EEGSNITYRTELVHLYLKENKYTKAIPHLLKAKDLRALTIIKIQNLLPQYLDQIVDIILL 725

Query: 591 LCELDTTLVLEYSMLVLESCPTQTIELFLSGNIPADMVNLY--LKQHAPN----LQATYL 644
             + + + + + S+  +++   + I+L         +  +Y   +   P     +   YL
Sbjct: 726 PYKGEISHISKLSIFEIQTIFNKPIDLLFENRHTISVARIYEIFEHDCPKSFKKILFCYL 785

Query: 645 ELVLSMNEGAVSGTLQNEMVHLYLSEVLDWHADLSSEQKWDEKVYSPKRKKLLSALESIS 704
              L  ++  +    +N+++ LY               ++D       R+ LL  L+  +
Sbjct: 786 IKFLDTDDSFMISPYENQLIELY--------------SEYD-------RQSLLPFLQKHN 824

Query: 705 GYNPEALLKLLPSD-ALYEERAILLGKMNQHELALSLYVHKLHVPELALSY 754
            YN E+ +++  S   LY E   L GK+ + + ALSL + +L  P+LA+ +
Sbjct: 825 NYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDELKNPQLAIDF 875


>VP41_CAEEL (Q19954) Vacuolar assembly protein VPS41 homolog
          Length = 876

 Score = 38.5 bits (88), Expect = 0.090
 Identities = 33/119 (27%), Positives = 45/119 (37%), Gaps = 24/119 (20%)

Query: 637 PNLQATYLELVLSMNEGAVSGTLQNEMVHLYLSEVLDWHADLSSEQKWDEKVYSPKRKKL 696
           P LQ  YL  ++S NEG       ++ V LY               ++D+K       KL
Sbjct: 616 PKLQLAYLTKLMSRNEGT---EFADKAVQLYA--------------EYDQK-------KL 651

Query: 697 LSALESISGYNPEALLKLLPSDALYEERAILLGKMNQHELALSLYVHKLHVPELALSYC 755
           L  L   + YN     KL       EE   LL K   H  A+ + V +    E  + YC
Sbjct: 652 LPFLRKNANYNVNKARKLCSDKGYIEETIYLLAKSGNHYDAVKMMVREYRNMEKVIDYC 710


>GPT2_YEAST (P36148) Glycerol-3-phosphate O-acyltransferase 2 (EC
           2.3.1.15) (G-3-P acyltransferase 2) (Dihydroxyacetone
           phosphate acyltransferase 2) (EC 2.3.1.42) (DHAP-AT 2)
           (Glycerol-3-phosphate / dihydroxyacetone phosphate
           acyltransferase 2)
          Length = 743

 Score = 36.6 bits (83), Expect = 0.34
 Identities = 23/64 (35%), Positives = 31/64 (47%), Gaps = 2/64 (3%)

Query: 805 SIRKVTSKSLSRTMSRGSKKIAAIEIAEDAKASQSSDSGRSDADTEEFTEEECTSIMLDE 864
           SI  + S +LSR  SRGS  +  I I  DAK  Q    G +  D +EF E+    +    
Sbjct: 654 SIGSLASNALSRVNSRGS--LTDIPIFSDAKQGQWKSEGETSEDEDEFDEKNPAIVQTAR 711

Query: 865 ALDL 868
           + DL
Sbjct: 712 SSDL 715


>MLH1_SCHPO (Q9P7W6) Putative MUTL protein homolog 1 (DNA mismatch
           repair protein MLH1)
          Length = 684

 Score = 36.2 bits (82), Expect = 0.45
 Identities = 30/121 (24%), Positives = 57/121 (46%), Gaps = 10/121 (8%)

Query: 742 VHKLHVPELALSYCDHVYESAHKSSVKSLSNIYLMLLQI------YLNPRRTTKNYEKKI 795
           VH L+  E+A S CD + E   ++  +    +  M+  I        + ++  + YE  +
Sbjct: 325 VHFLYDQEIATSICDKLGEILERTDTERSYPLQAMIPSISNTKNAESSSQKAVRTYENYL 384

Query: 796 SNLLSPRNKSIRKVTSKS-LSRTMSRGSKKIAAIEIAEDAKASQSSDSGRSDADTEEFTE 854
                PR +SI+ + S + L R+ +    +I  IE  + A +++++ +   D  TEE  E
Sbjct: 385 VR-TDPRERSIKSMLSDNFLQRSSNNYDNEI--IEKVDSANSNKNATNDIKDLQTEEIVE 441

Query: 855 E 855
           E
Sbjct: 442 E 442


>KNTC_HUMAN (P50748) Kinetochore-associated protein 1 (Rough deal
            homolog) (hRod) (HsROD) (Rod)
          Length = 2209

 Score = 35.8 bits (81), Expect = 0.58
 Identities = 82/416 (19%), Positives = 164/416 (38%), Gaps = 75/416 (18%)

Query: 577  HRFKPEAIIEYLKPLCELDTTLVLEYSMLVLESCPTQTIELFL--------SGNIPADMV 628
            H    + +I+ L    ++DT+L+LEY       C    ++LF+        +G    D  
Sbjct: 1425 HFLTKKDLIKALVENIDMDTSLILEYCSTFQLDCDA-VLQLFIETLLHNTNAGQGQGDAS 1483

Query: 629  NLYLKQHAPNLQATYLELVLSMNEG-----AVSGTLQN------EMVHLYLSEVLDWHAD 677
                K+  P L A  LE+V  +        ++SG L        EM+ + L  +      
Sbjct: 1484 MDSAKRRHPKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVI------ 1537

Query: 678  LSSEQKWDEKVYSPKRKKLLSALESISGYN--------------------PEALLKLLPS 717
                ++ DEK+ +    + LS L+ +  Y                     P A    LP 
Sbjct: 1538 ----ERADEKITNININQALSILKHLKSYRRISPPVDLEYQYMLEHVITLPSAAQTRLPF 1593

Query: 718  DALYEERA-----ILLGKMNQHELALSLYVHKL---HVPELALSYCDHVYESAHKSSVKS 769
              ++   A     IL  ++++      L + KL    +  L +S   HV+E   K  +  
Sbjct: 1594 HLIFFGTAQNFWKILSTELSEESFPTLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLK 1653

Query: 770  LSNIYLMLLQIYLNPRRTTKNYEKKISNLLSPRNKSIRKVTSKSLSRTMSRGSKKIAAIE 829
            L+      L   +N +  TK  +   S LLS  N       + SL++ +  GS KI+A++
Sbjct: 1654 LTQAKSSTL---IN-KEITKITQTIESCLLSIVNPEWAVAIAISLAQDIPEGSFKISALK 1709

Query: 830  IAEDAKASQSSDSGRSDADTEEFTEEECTSIMLDEALDLLSRRWDRINGAQALKLLPKET 889
                      ++    +  +++   E+  +++  + L +  RR    +G +A+ L+  + 
Sbjct: 1710 F-----CLYLAERWLQNIPSQDEKREKAEALL--KKLHIQYRR----SGTEAV-LIAHKL 1757

Query: 890  KLQNLLPILGPLVRKSSEMYRNCSVVRSLRQSENLQVKDELYNKRKAVIKISDDNM 945
              +  L ++G        +Y + S+ + ++ S      D ++   K + ++++ N+
Sbjct: 1758 NTEEYLRVIGKPAHLIVSLYEHPSINQRIQNSSGTDYPD-IHAAAKEIAEVNEINL 1812


>TNIK_MOUSE (P83510) Traf2 and NCK interacting kinase (EC 2.7.1.37)
           (Fragments)
          Length = 916

 Score = 35.0 bits (79), Expect = 0.99
 Identities = 24/101 (23%), Positives = 49/101 (47%), Gaps = 8/101 (7%)

Query: 164 ICLGIRKAYVILNATSGSISEVFT----SGRLAPPLVVSLPSG---ELLLGKDNIGVIVD 216
           +  G    + +++  SG+  +++      G + P  +V LP     E+L+  ++ GV V+
Sbjct: 763 VIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVN 822

Query: 217 QNGKLRPEGRICWSEAPTEVV-IQNPYALALLPRFVEIRSL 256
             G++  +  + W E PT V  I +   +    + +EIRS+
Sbjct: 823 TYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSV 863


>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK interacting kinase (EC 2.7.1.37)
          Length = 1360

 Score = 35.0 bits (79), Expect = 0.99
 Identities = 24/101 (23%), Positives = 49/101 (47%), Gaps = 8/101 (7%)

Query: 164  ICLGIRKAYVILNATSGSISEVFT----SGRLAPPLVVSLPSG---ELLLGKDNIGVIVD 216
            +  G    + +++  SG+  +++      G + P  +V LP     E+L+  ++ GV V+
Sbjct: 1207 VIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVN 1266

Query: 217  QNGKLRPEGRICWSEAPTEVV-IQNPYALALLPRFVEIRSL 256
              G++  +  + W E PT V  I +   +    + +EIRS+
Sbjct: 1267 TYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSV 1307


>ROM1_YEAST (P53046) RHO1 GDP-GTP exchange protein 1 (Protein kinase C
            suppressor SKC1)
          Length = 1155

 Score = 35.0 bits (79), Expect = 0.99
 Identities = 40/181 (22%), Positives = 72/181 (39%), Gaps = 38/181 (20%)

Query: 147  DFGVLDVVKSMSWCGENICLGIRKAYVILNATSGSISEVFTSGRLAPPLVVSLPSGELLL 206
            DF V     S S+    IC+G +K   ILN     + EV          +++L   ++L 
Sbjct: 987  DFSVDSEPLSFSFLENKICIGCKKNIKILN-----VPEVCDKNGFKMRELLNLHDNKVLA 1041

Query: 207  G--KDNIGVI-------------------VDQNGKLRPEGRIC--WSEAPTEVVIQNPYA 243
               K+   V+                   +++ GK R E + C  W   P +     PY 
Sbjct: 1042 NMYKETFKVVSMFPIKNSTFACFPELCFFLNKQGK-REETKGCFHWEGEPEQFACSYPYI 1100

Query: 244  LALLPRFVEIRSLRGPYPLIQTIVFRNVRHLRQSNNSVIIALENSIHCLFPVPLGAQIVQ 303
            +A+   F+EIR +     L++ ++   +R L+     ++   E+        P G +I++
Sbjct: 1101 VAINSNFIEIRHIENG-ELVRCVLGNKIRMLKSYAKKILYCYED--------PQGFEIIE 1151

Query: 304  L 304
            L
Sbjct: 1152 L 1152


>PKND_CHLMU (Q9PK92) Serine/threonine-protein kinase pknD (EC
           2.7.1.37)
          Length = 934

 Score = 34.7 bits (78), Expect = 1.3
 Identities = 27/109 (24%), Positives = 48/109 (43%), Gaps = 4/109 (3%)

Query: 697 LSALESISGYNPEALLKLLPSDALYEERAILLGKMNQHELALSLYVHKLHVPELALSYCD 756
           LS  + + G +  A L+ L    +Y+     + ++    LAL  Y     +P L    C 
Sbjct: 541 LSTFDLLHG-STGAPLEYLGKALVYQRNGSFVEEIRSLLLALKRYPQHPEIPRLKDHLCF 599

Query: 757 HVYESAHKSSVKSLSNIYLMLLQIYLNPRRTTKNYEKKISNLLSPRNKS 805
            +Y+S HK   ++L     MLL +++ P +     E++    L  R +S
Sbjct: 600 RLYDSLHKHRSEAL---VFMLLILWIAPEKIGLREEERFLEFLHHRQQS 645


>NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC
           2.7.1.37) (N-rich kinase 1)
          Length = 652

 Score = 34.3 bits (77), Expect = 1.7
 Identities = 24/91 (26%), Positives = 42/91 (45%), Gaps = 2/91 (2%)

Query: 371 TSIILPKTTIVHDSDKLDIFGDPLHLSRGSSMSDDMEPSSASNMSELDDNAELESKKMSH 430
           T  ++PK++ VH+    +     L L + S +SDD  PS+A   S  D   E+   ++  
Sbjct: 354 TGTVIPKSSTVHEPPSSNDSHPLLQLFKDSKISDDDSPSNAEGASTEDSKGEVSYSQIEL 413

Query: 431 NMLMALIKFLHKKRHSIIEKATAEGTEEVVF 461
             L +    L  K+ +I  K T +  +  +F
Sbjct: 414 PSLDS--SNLSSKKSTIQSKHTKQAEDYDLF 442


>RECN_AQUAE (O66834) DNA repair protein recN (Recombination protein
           N)
          Length = 520

 Score = 33.9 bits (76), Expect = 2.2
 Identities = 21/53 (39%), Positives = 32/53 (59%), Gaps = 4/53 (7%)

Query: 647 VLSMNEGAVSGTLQNEMVHLYLSE----VLDWHADLSSEQKWDEKVYSPKRKK 695
           VL + EG +S   QNE ++L+  +    +LD  A+L+ + K  EKVY+  RKK
Sbjct: 93  VLELLEGKISLQGQNEFINLFREDFQRKLLDTFANLNDKVKELEKVYNSLRKK 145


>G59F_DROME (Q9W1N5) Putative gustatory receptor 59f
          Length = 406

 Score = 33.5 bits (75), Expect = 2.9
 Identities = 21/71 (29%), Positives = 37/71 (51%), Gaps = 2/71 (2%)

Query: 739 SLYVHKLHVPELALSYCDHVYESAHKSSVKSLSNIYLMLLQIYLNPRRTTKNYEKKISNL 798
           +++ HK  V    LS   +V  +   S   S +  YL+L  I    RR T+  E+++++L
Sbjct: 171 NIWTHKFVVYRSILSINSYVMPNIISSI--SFAQYYLLLQGIAWRQRRLTEGLERELTHL 228

Query: 799 LSPRNKSIRKV 809
            SPR   ++K+
Sbjct: 229 HSPRISEVQKI 239


>Y111_ENCCU (Q8STB5) Hypothetical protein
           ECU01_0110/ECU01_1500/ECU08_0040
          Length = 592

 Score = 33.1 bits (74), Expect = 3.8
 Identities = 28/113 (24%), Positives = 51/113 (44%), Gaps = 5/113 (4%)

Query: 762 AHKSSVKSLSNIYLMLLQIYLNPRRTTKNYEKKISNLLSPRNKSIRKVTSKSLSRTMSRG 821
           AHK     ++   +M + +    +   K Y  K++N++  R +   +   K++   M R 
Sbjct: 266 AHKEHGGDVTKELVMQMLLGKKGKNIDKRYINKVANVVKERQRRREREIEKNMKELM-RD 324

Query: 822 SKKIAAIEIA---EDAKASQSSDS-GRSDADTEEFTEEECTSIMLDEALDLLS 870
            +K  + E A   E AK+ +  +S G S+A  EE  E E   +   E + + S
Sbjct: 325 EEKAKSKEKAKSKEKAKSKKKGESVGVSEAKEEEKKESETEEVEASEEVGIPS 377


>SL2B_HUMAN (Q8NEV8) Slp homolog lacking C2 domains-b (Exophilin 5)
          Length = 1989

 Score = 33.1 bits (74), Expect = 3.8
 Identities = 62/259 (23%), Positives = 90/259 (33%), Gaps = 48/259 (18%)

Query: 747  VPELALSYCDHVYESAHKSSVKSLSNIYLMLLQIYLNPRRTTKNYEKKISNLLSPRNKSI 806
            +P  + S+  H  +S  K    SL N      QI  N      NY   + N  SP +   
Sbjct: 1022 LPRKSSSFLIHGRQSGSKIMAASLRN-GPPPFQIKNNVEDAMGNY---MLNKFSPSSPES 1077

Query: 807  RKVTSKSLS--------------RTMSRGSKKIAAIEIAEDAKASQSSDSGRSDADT-EE 851
                SK LS                 S GS  +    +      + S  SG   A T  E
Sbjct: 1078 ANECSKVLSDSALEAPEATERMTNVKSSGSTSVRKGPLPFLINRAMSCPSGEPHASTGRE 1137

Query: 852  FTEEECTSIMLDEALDLLSRRWDRINGAQALKLLPKETKLQNLLPILGPLVRKSSEMYRN 911
              ++  TS M  +A +L  R W+RI                     + P+   SS   R+
Sbjct: 1138 GRKKPLTSGM--DASELTPRAWERI---------------------ISPVESDSS--VRD 1172

Query: 912  CSVVRSLRQSENLQVKDELYNK----RKAVIKISDDNMCSLCHKKIGTSVFAVYPNGKTL 967
            CS+ +   Q EN Q   E   K    R++V  +S+++    C    G          KT 
Sbjct: 1173 CSLTKRQHQKENFQEYTEKEGKMAASRRSVFALSNEDPLPFCSDLSGKERGKTLHKVKTT 1232

Query: 968  VHFVCFRDSQSMKAVAKVS 986
              F    D  ++K +  VS
Sbjct: 1233 STFSVSGDEDNVKCLEVVS 1251


>MI15_CAEEL (Q23356) Serine/threonine-protein kinase mig-15 (EC
            2.7.1.37) (Abnormal cell migration protein 15)
          Length = 1080

 Score = 33.1 bits (74), Expect = 3.8
 Identities = 27/101 (26%), Positives = 49/101 (47%), Gaps = 8/101 (7%)

Query: 164  ICLGIRKAYVILNATSGSISEVFT---SGRLAPP-LVVSLPSG---ELLLGKDNIGVIVD 216
            +  G    +  ++  S ++ +++T   SG+   P  +V LP+    +LLL  DN GV V+
Sbjct: 927  VLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVN 986

Query: 217  QNGKLRPEGRICWSEAPTEVV-IQNPYALALLPRFVEIRSL 256
              G++     + W E P+ V  I     +    + +EIRS+
Sbjct: 987  TYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSV 1027


>MAD1_DEBHA (Q6BSY1) Spindle assembly checkpoint component MAD1
           (Mitotic arrest deficient protein 1)
          Length = 669

 Score = 33.1 bits (74), Expect = 3.8
 Identities = 62/306 (20%), Positives = 117/306 (37%), Gaps = 38/306 (12%)

Query: 466 NNFESYNSNRFKKINKRHGSIPVSSEAREMASILDTALLQAMLLTGQPSMAENLLRVLNY 525
           +N +   S    K+   + ++   +E       +D    Q +L   +     +LL+ L  
Sbjct: 321 SNMQQKYSEAISKVESLNETVSTKTE------FIDKLERQKLLNVKEIEYLRDLLKKLEE 374

Query: 526 CDLKICEEILQEGSYHVSLVELYKCNSMHREALEIINKSVKESE-----SSQSK------ 574
            +LK  +E   + S    +  L K    +R  +  + K +   E      S SK      
Sbjct: 375 LNLKRSKEETNDKSTEQYMTNLEKLVDEYRTEINTLQKQMLSQEIQSNVQSGSKRPRIID 434

Query: 575 --IAHRFKPEAIIEYLKPLCELDTTLVLEYSMLVLESCPTQTIELFLSGNIPADMVNLYL 632
             I + FK +  +   + L  L T   LEY+   L     Q +E     N   ++  L L
Sbjct: 435 NGIQNDFKSQVSVLEKENLKLLSTIKNLEYNNKTLGE-KLQNLESL--DNKKKELHILQL 491

Query: 633 KQHAPN----LQATYLELVLSMNEGAVSGTLQNEMVHLYLSEVLDWHAD---LSSEQKWD 685
           K +  +    ++   L+L+   N+  +   ++N+  H  + + L    +   L  + K D
Sbjct: 492 KSNPASQDQLIKQQTLDLLSKENQEMIETFVKNKSAHDMIPKSLFERQENDKLQLQTKID 551

Query: 686 E---------KVYSPKRKKLLSALESISGYNPEALLKLLPSDALYEERAILLGKMNQHEL 736
           +          +YS K + +LS +    GY  E L   + S+ L     ++   MN  + 
Sbjct: 552 QLNKRISRLRDIYSQKSRDILSVISKFFGYTIEFLPSPINSNDLSSRIKLVSKYMNNKDE 611

Query: 737 ALSLYV 742
           + S Y+
Sbjct: 612 SNSAYL 617


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.317    0.133    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,899,572
Number of Sequences: 164201
Number of extensions: 4398904
Number of successful extensions: 12481
Number of sequences better than 10.0: 34
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 12442
Number of HSP's gapped (non-prelim): 47
length of query: 992
length of database: 59,974,054
effective HSP length: 120
effective length of query: 872
effective length of database: 40,269,934
effective search space: 35115382448
effective search space used: 35115382448
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)