BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC147714.15 + phase: 0
(663 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion tran... 422 e-117
MRP2_RAT (Q63120) Canalicular multispecific organic anion transp... 421 e-117
MRP2_HUMAN (Q92887) Canalicular multispecific organic anion tran... 417 e-116
YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium... 407 e-113
MRP2_RABIT (Q28689) Canalicular multispecific organic anion tran... 404 e-112
MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1 (A... 397 e-110
MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1 (A... 391 e-108
YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c 367 e-101
MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4 (M... 365 e-100
MRP3_HUMAN (O15438) Canalicular multispecific organic anion tran... 363 e-100
MRP3_RAT (O88563) Canalicular multispecific organic anion transp... 357 6e-98
ACC9_RAT (Q63563) Sulfonylurea receptor 2 352 1e-96
BPT1_YEAST (P14772) Bile pigment transporter 1 352 2e-96
MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5 350 5e-96
ACC9_HUMAN (O60706) Sulfonylurea receptor 2 350 9e-96
YH85_SCHPO (Q9P5N0) Probable ATP-dependent permease C359.05 349 2e-95
ACC9_MOUSE (P70170) Sulfonylurea receptor 2 349 2e-95
ACC9_RABIT (P82451) Sulfonylurea receptor 2 348 3e-95
MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5 (M... 346 1e-94
MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (A... 344 4e-94
>MRP2_MOUSE (Q8VI47) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2)
Length = 1543
Score = 422 bits (1086), Expect = e-117
Identities = 234/588 (39%), Positives = 351/588 (58%), Gaps = 13/588 (2%)
Query: 45 RASIKITQTLVENKGKEA-NGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGH 103
++S+KI NK +E G +LIK+E E G YL+YL + + F+ + +
Sbjct: 926 KSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIV-IFY 984
Query: 104 FIFLVCQILQNLWMAA---------NVDNPRVSTFQLIFVYFLLGASSAFFMLTRSLFVI 154
+ V I NLW++A DN I V+ LG + F+L+ SL+ I
Sbjct: 985 VLNYVAFIGTNLWLSAWTSDSEKQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSI 1044
Query: 155 ALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTT 214
+SK L QL+ ++ RAPM F+D TP GRI++R + ++S +D +P +L +
Sbjct: 1045 YACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCF 1104
Query: 215 MNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAET 274
STL + + T +I+ IP+ + + +Q +Y A+++++ R+ TKS + +H +ET
Sbjct: 1105 FGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSET 1164
Query: 275 VSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCM 334
VSG IR FE + RF + ID N F SN WL RLE + ++ +AL +
Sbjct: 1165 VSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLL 1224
Query: 335 VILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEI 394
VI + T +G LS L + L ++ + I++VER+N+Y+++ +EA +
Sbjct: 1225 VIYK-NSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWV 1283
Query: 395 VEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLI 454
+ +PP +WP G+++ N+ ++RYRP+ LVL GITC + K+G+VGRTG+GKS+L
Sbjct: 1284 TD-KKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLT 1342
Query: 455 SALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQ 514
+ LFR++E +GG IIIDG+DI+SIGLHDLR R IIPQDP LF+G +R NLDP ++YSD+
Sbjct: 1343 NCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDE 1402
Query: 515 EIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEAT 574
EIW L L+ V GL V E G N S+GQRQL CLGRA+LR+S+ILVLDEAT
Sbjct: 1403 EIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEAT 1462
Query: 575 ASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
A+VD TD ++ TIR EF+ CTVIT+AHR+ T+MD ++ ++ G +
Sbjct: 1463 AAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKI 1510
Score = 66.2 bits (160), Expect = 3e-10
Identities = 58/237 (24%), Positives = 106/237 (44%), Gaps = 24/237 (10%)
Query: 342 FTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPP 401
FTS + L + LA+ +++S+ +SV+RL +Y+ + R
Sbjct: 578 FTSITLFNILRFPLAMLPMVISSV------IQASVSVDRLERYLGSDDLDLSAI---RHV 628
Query: 402 LNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLV 461
++ A V+ ++ + D + + + G + +VG GSGKS+LISA+ +
Sbjct: 629 CHFDKA--VQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEM 686
Query: 462 EPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLG 521
E G+I I G +PQ + GT++ N+ S+Y +++ V+
Sbjct: 687 ENVHGHITIKG-------------SIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIE 733
Query: 522 KCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVD 578
C L ++ G + + E G N S GQ+ L RA + + I +LD+ ++VD
Sbjct: 734 ACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVD 790
>MRP2_RAT (Q63120) Canalicular multispecific organic anion transporter
1 (ATP-binding cassette, sub-family C, member 2)
(Multidrug resistance-associated protein 2) (Canalicular
multidrug resistance protein)
Length = 1541
Score = 421 bits (1082), Expect = e-117
Identities = 237/586 (40%), Positives = 352/586 (59%), Gaps = 13/586 (2%)
Query: 47 SIKITQT-LVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFI 105
S+KI +++ K KE G +LIK+E E G YL+YL + + F+ L + +
Sbjct: 926 SLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFII-LFYGL 984
Query: 106 FLVCQILQNLWMAA---------NVDNPRVSTFQLIFVYFLLGASSAFFMLTRSLFVIAL 156
V I NLW++A +N I V+ LG + +L +L+ I
Sbjct: 985 NNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYA 1044
Query: 157 GLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMN 216
+SK L QL+ ++ RAPM F+D TP GRI++R S ++S +D +P +L +
Sbjct: 1045 CRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFG 1104
Query: 217 FYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVS 276
TL + + T I+ IP+ + I +Q +Y A+++++ R+ TKS + +H +ETV+
Sbjct: 1105 IAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVT 1164
Query: 277 GAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVI 336
G IR FE + RF N IDIN F SN WL RLE + V+ +AL +VI
Sbjct: 1165 GLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVI 1224
Query: 337 LPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVE 396
T T +G LS L + L ++ I++VER+++Y+++++EA + +
Sbjct: 1225 YRK-TLTGDVVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPWVTD 1283
Query: 397 GNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISA 456
RPP +WP G+++ N+ ++RYRP+ LVL GITC + G K+G+VGRTG+GKS+L +
Sbjct: 1284 -KRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNC 1342
Query: 457 LFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEI 516
LFR++E +GG IIIDG+D++SIGLHDLR R IIPQDP LF+G++R NLDP ++YSD+E+
Sbjct: 1343 LFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEV 1402
Query: 517 WEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATAS 576
W L LR V GL S V E G N S+GQRQL CLGRA+LR+S+ILVLDEATA+
Sbjct: 1403 WRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAA 1462
Query: 577 VDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
VD TD ++ TIR EF+ CTVIT+AHR+ T+MD ++ +++G +
Sbjct: 1463 VDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKI 1508
Score = 72.4 bits (176), Expect = 4e-12
Identities = 67/258 (25%), Positives = 117/258 (44%), Gaps = 26/258 (10%)
Query: 321 TISAGVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVER 380
T S VL +A V+ FTS + L + L++ + +SI +SV+R
Sbjct: 557 TFSVYVLVDSA--NVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQAS------VSVDR 608
Query: 381 LNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKI 440
L +Y+ + R N+ A V+ ++ + PD + + + G +
Sbjct: 609 LERYLGGDDLDTSAI---RRVSNFDKA--VKFSEASFTWDPDLEATIQDVNLDIKPGQLV 663
Query: 441 GIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGT 500
+VG GSGKS+L+SA+ +E G+I I G +PQ + GT
Sbjct: 664 AVVGTVGSGKSSLVSAMLGEMENVHGHITIQGST-------------AYVPQQSWIQNGT 710
Query: 501 VRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRA 560
++ N+ S+Y++++ +VL C L ++ G + + E G N S GQ+Q L RA
Sbjct: 711 IKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARA 770
Query: 561 LLRRSRILVLDEATASVD 578
+ + I +LD+ ++VD
Sbjct: 771 AYQDADIYILDDPLSAVD 788
>MRP2_HUMAN (Q92887) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2) (Multidrug resistance-associated protein 2)
(Canalicular multidrug resistance protein)
Length = 1545
Score = 417 bits (1072), Expect = e-116
Identities = 232/568 (40%), Positives = 338/568 (58%), Gaps = 12/568 (2%)
Query: 64 GNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFLVCQILQNLWMAA---- 119
G +LIK+E E G YL+YL + + FF+ L + V I NLW++A
Sbjct: 948 GQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFII-LAFVMNSVAFIGSNLWLSAWTSD 1006
Query: 120 -----NVDNPRVSTFQLIFVYFLLGASSAFFMLTRSLFVIALGLQSSKYLFLQLMNSLFR 174
+ D P + VY LG + F+ + + +S L QL+N++ R
Sbjct: 1007 SKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILR 1066
Query: 175 APMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIV 234
APM F+D TP GRI++R + ++S +D +P SL + + STL + + T I+
Sbjct: 1067 APMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTII 1126
Query: 235 AIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGAVTIRTFEEEDRFFQKN 294
IP+ I + +Q +Y ++++++ R+ T+S + +H +ETVSG IR FE + RF + N
Sbjct: 1127 VIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHN 1186
Query: 295 LDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVILPPGTFTSGFIGMALSYG 354
ID N F SN WL RLE + + +AL MVI T + +G LS
Sbjct: 1187 EVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRD-TLSGDTVGFVLSNA 1245
Query: 355 LALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEIND 414
L + L ++ + I++VER+ +Y +++EA + + RPP +WP GK++ N+
Sbjct: 1246 LNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTD-KRPPPDWPSKGKIQFNN 1304
Query: 415 LKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVD 474
++RYRP+ LVL GITC KIG+VGRTG+GKS+L + LFR++E +GG IIIDGVD
Sbjct: 1305 YQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVD 1364
Query: 475 ISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDE 534
I+SIGLHDLR + IIPQDP LF+G++R NLDP + YSD+EIW+ L L+ V
Sbjct: 1365 IASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQL 1424
Query: 535 GLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNSTDYILLKTIRTEFA 594
GL+ V E G N S+GQRQL CLGRALLR+S+ILVLDEATA+VD TD ++ TI+ EFA
Sbjct: 1425 GLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFA 1484
Query: 595 DCTVITVAHRIPTVMDCTMVLSINDGNL 622
CTVIT+AHR+ T+MD V+ +++G +
Sbjct: 1485 HCTVITIAHRLHTIMDSDKVMVLDNGKI 1512
Score = 65.9 bits (159), Expect = 3e-10
Identities = 56/237 (23%), Positives = 105/237 (43%), Gaps = 24/237 (10%)
Query: 342 FTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPP 401
FTS + L + L++ +++S + +S ERL +Y+ + R
Sbjct: 580 FTSITLFNILRFPLSMLPMMISS------MLQASVSTERLEKYLGGDDLDTSAI---RHD 630
Query: 402 LNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLV 461
N+ A ++ ++ + D + + G + ++G GSGKS+LISA+ +
Sbjct: 631 CNFDKA--MQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEM 688
Query: 462 EPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLG 521
E G+I I G +PQ + GT++ N+ ++++++ +VL
Sbjct: 689 ENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLE 735
Query: 522 KCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVD 578
C L ++ G + + E G N S GQ+Q L RA + I +LD+ ++VD
Sbjct: 736 ACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVD 792
>YCFI_YEAST (P39109) Metal resistance protein YCF1 (Yeast cadmium
factor 1)
Length = 1515
Score = 407 bits (1046), Expect = e-113
Identities = 230/587 (39%), Positives = 347/587 (58%), Gaps = 25/587 (4%)
Query: 67 LIKQEEREKGDKGLKPYLQYL---NQMKGYIFFFVASLGHFIFLVCQILQNLWMAANV-- 121
+ K+E RE+G YL+Y N +F + F+ ++ + W N
Sbjct: 923 IAKREHREQGKVKWNIYLEYAKACNPKSVCVFILFIVISMFLSVMGNVWLKHWSEVNSRY 982
Query: 122 -DNPRVSTFQLIFVYFLLGASSAFFMLTRSLFV-IALGLQSSKYLFLQLMNSLFRAPMPF 179
NP + + + +YF LG SA L +++ + + + +SKYL + NS+ RAPM F
Sbjct: 983 GSNPNAARY--LAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTF 1040
Query: 180 YDCTPLGRILSRVSSELSIMD--LDIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIVAIP 237
++ TP+GRIL+R S+++ +D L FS F + F T+TV TWQ + + IP
Sbjct: 1041 FETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTF--TITVICATTWQFIFIIIP 1098
Query: 238 MVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGAVTIRTFEEEDRFFQKNLDL 297
+ I Q+YY +++E+ R+ T+S + +H ET+ G T+R + ++ RF N
Sbjct: 1099 LSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCR 1158
Query: 298 IDINASSFFHNFASNEWLIQRLETI-SAGVLASAALCMVILPPGTFTSGFIGMALSYGLA 356
ID N S+F+ + +N WL RLE I S +L +A L + L GT T+G +G++LSY L
Sbjct: 1159 IDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQ 1218
Query: 357 LNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLK 416
+ L ++ + I+SVER+ +Y ++SEA IVEG+RPP WP G ++ N+
Sbjct: 1219 ITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDIKFNNYS 1278
Query: 417 IRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDIS 476
RYRP+ LVL I + K+GIVGRTG+GKS+L ALFR++E S GNI+ID + I+
Sbjct: 1279 TRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAIN 1338
Query: 477 SIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLRE-VVQEKDEG 535
IGL+DLR + IIPQD +F GTVR N+DP++QY+D+ IW L L+E V+ ++G
Sbjct: 1339 EIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDG 1398
Query: 536 LNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNSTDYILLKTIRTEFAD 595
L++ + E G N S+GQRQL CL RA+L S+ILVLDEATA+VD TD ++ +TIRT F D
Sbjct: 1399 LDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKD 1458
Query: 596 CTVITVAHRIPTVMDCTMVLSINDGN----------LSRNTGLIFSL 632
T++T+AHR+ T+MD ++ +++G LS N L +SL
Sbjct: 1459 RTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSL 1505
Score = 47.0 bits (110), Expect = 2e-04
Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 15/160 (9%)
Query: 420 RPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSI- 478
+P+ + L I + G+ IVG+ GSGK+ L+S + D+ +
Sbjct: 639 KPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLG--------------DLFRVK 684
Query: 479 GLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNS 538
G + + Q P + GTV+ N+ +Y + + + C L + +G +
Sbjct: 685 GFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKT 744
Query: 539 SVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVD 578
V E G + S GQ+ L RA+ R+ +LD+ A+VD
Sbjct: 745 LVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVD 784
>MRP2_RABIT (Q28689) Canalicular multispecific organic anion
transporter 1 (ATP-binding cassette, sub-family C, member
2) (Multidrug resistance-associated protein 2)
(Canalicular multidrug resistance protein) (Epithelial
basolateral chloride conductance r
Length = 1564
Score = 404 bits (1039), Expect = e-112
Identities = 231/590 (39%), Positives = 347/590 (58%), Gaps = 22/590 (3%)
Query: 47 SIKITQTLVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLN-----QMKGYIFFFVASL 101
S+K + + G +LIK+E E G YL+YL + G IF +V +
Sbjct: 929 SLKAQNGKTPKEEEVVKGQKLIKKEFMETGKVKFSIYLKYLQAIGWCSIVGIIFAYVLNS 988
Query: 102 GHFIFLVCQILQNLWMAA--------NVDNPRVSTFQL-IFVYFLLGASSAFFMLTRSLF 152
FI NLW++A N N S L I ++ +LG + +L S +
Sbjct: 989 VAFIG------SNLWLSAWTSDSNTYNGTNYPASQRDLRIGIFGVLGLAQGLTVLVASFW 1042
Query: 153 VIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVG 212
+ +S L QL+N++ RAPM F++ TP+GRI++R + ++S +D +P SL +
Sbjct: 1043 SASGCAHASNILHKQLLNNILRAPMSFFNTTPIGRIVNRFAGDISTVDDTLPQSLRSWMM 1102
Query: 213 TTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVA 272
+ STL + + T ++ IP+ I + +Q +Y A+++++ R+ T+S + +H
Sbjct: 1103 CFLAIISTLIMICMATPVFAVIIIPLAIIYVAVQVFYVATSRQLRRLDSVTRSPIYSHFT 1162
Query: 273 ETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAAL 332
ETVSG IR FE + RF ++N ID N SN WL RLE + V+ S+AL
Sbjct: 1163 ETVSGLPVIRAFEHQQRFLKQNEIGIDTNQKCVSSWITSNRWLAFRLELVGNLVVFSSAL 1222
Query: 333 CMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAK 392
MVI T + +G LS L + L ++ I++VER+ +Y+ +++EA
Sbjct: 1223 MMVIYRD-TLSGDVVGFVLSNALNITQTLNWLVRMTSETETNIVAVERITEYIKVENEAP 1281
Query: 393 EIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKST 452
+ + RPP WP G+++ ++ ++RYRP+ LVL GI C + KIG+VGRTG+GKS+
Sbjct: 1282 WVTD-KRPPAGWPHKGEIQFSNYQVRYRPELDLVLKGINCDIKSMEKIGVVGRTGAGKSS 1340
Query: 453 LISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYS 512
L + LFR++E +GG+I IDG+DI+SIGLHDLR + IIPQDP LF+G++R NLDP + YS
Sbjct: 1341 LTNCLFRILEAAGGHITIDGIDIASIGLHDLRGKLTIIPQDPVLFSGSLRMNLDPFNNYS 1400
Query: 513 DQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDE 572
D+EIW L L+ V GL+ V E N S+GQRQL CLGRALLR+S+ILVLDE
Sbjct: 1401 DEEIWRALELAHLKSFVAGLQHGLSREVSEAEDNLSIGQRQLLCLGRALLRKSKILVLDE 1460
Query: 573 ATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
ATA+VD TD+++ TIR EF+ CTVIT+AHR+ T+MD ++ +++GN+
Sbjct: 1461 ATAAVDLETDHLIQTTIRNEFSHCTVITIAHRLHTIMDSDKIMVLDNGNI 1510
Score = 62.8 bits (151), Expect = 3e-09
Identities = 52/203 (25%), Positives = 93/203 (45%), Gaps = 18/203 (8%)
Query: 376 ISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFE 435
+SV+RL +Y+ ++ R P N+ A V+ ++ + + + +
Sbjct: 606 VSVDRLEKYLSGDDLDTSAIQ--RDP-NFDKA--VQFSEASFTWDRNLEPTIRNVNLDIM 660
Query: 436 VGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPT 495
G + +VG GSGKS+L+SA+ +E G+I I G +PQ
Sbjct: 661 PGQLVAVVGTVGSGKSSLMSAMLGEMENVHGHITIKGTT-------------AYVPQQSW 707
Query: 496 LFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLF 555
+ GT++ N+ +++ ++ VL C L ++ G + + E G N S GQ+Q
Sbjct: 708 IQNGTIKDNILFGAEFDERRYQRVLEACALLPDLEILPGGDLAEIGEKGINLSGGQKQRI 767
Query: 556 CLGRALLRRSRILVLDEATASVD 578
L RA + S I +LD+ ++VD
Sbjct: 768 SLARASYQNSDIYILDDPLSAVD 790
>MRP1_HUMAN (P33527) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1531
Score = 397 bits (1021), Expect = e-110
Identities = 238/667 (35%), Positives = 365/667 (54%), Gaps = 47/667 (7%)
Query: 1 MSEGVIQQEGPYQQLLATS-------------------------------KEFQDLVNAH 29
MS G I + G YQ+LLA KE + + N
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
Query: 30 KVTDGSNQLVNVTFSRASI------KITQTLVENKGKEANGNQLIKQEEREKGDKGLKPY 83
VTD + + + S +S + + E + EA + K E +K G
Sbjct: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
Query: 84 LQYLNQMKGYIFFFVASLGHFIFL---VCQILQNLWMAANVDNPRVSTFQ-----LIFVY 135
Y + MK I F++ L F+F+ V + N W++ D+P V+ Q + VY
Sbjct: 961 SVYWDYMKA-IGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 1019
Query: 136 FLLGASSAFFMLTRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSE 195
LG S + S+ V G+ +S+ L + L++S+ R+PM F++ TP G +++R S E
Sbjct: 1020 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1079
Query: 196 LSIMDLDIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKE 255
L +D IP + +G+ N V + T I+ P+ I +QR+Y AS+++
Sbjct: 1080 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1139
Query: 256 VMRITGTTKSYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWL 315
+ R+ ++S V +H ET+ G IR FEE++RF ++ +D N +++ + +N WL
Sbjct: 1140 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1199
Query: 316 IQRLETISAGVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQI 375
RLE + ++ AAL VI + ++G +G+++SY L + ++L ++ + I
Sbjct: 1200 AVRLECVGNCIVLFAALFAVI-SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
Query: 376 ISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFE 435
++VERL +Y + EA ++ PP +WP G+VE + +RYR D VL I T
Sbjct: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
Query: 436 VGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPT 495
G K+GIVGRTG+GKS+L LFR+ E + G IIIDG++I+ IGLHDLR + IIPQDP
Sbjct: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
Query: 496 LFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLF 555
LF+G++R NLDP SQYSD+E+W L L++ V + L+ E G N S+GQRQL
Sbjct: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1438
Query: 556 CLGRALLRRSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVL 615
CL RALLR+++ILVLDEATA+VD TD ++ TIRT+F DCTV+T+AHR+ T+MD T V+
Sbjct: 1439 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI 1498
Query: 616 SINDGNL 622
++ G +
Sbjct: 1499 VLDKGEI 1505
Score = 65.9 bits (159), Expect = 3e-10
Identities = 60/283 (21%), Positives = 122/283 (42%), Gaps = 19/283 (6%)
Query: 344 SGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLN 403
+ F+ +AL L ++ + S A+ +S++RL ++ + + +E RP +
Sbjct: 581 TAFVSLALFNILRFPLNILPMVISSIVQAS--VSLKRLRIFLSHEELEPDSIE-RRPVKD 637
Query: 404 WPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEP 463
+ + + + P L+GIT + G + +VG+ G GKS+L+SAL ++
Sbjct: 638 GGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDK 697
Query: 464 SGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKC 523
G++ I G +PQ + ++R N+ Q + V+ C
Sbjct: 698 VEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC 744
Query: 524 QLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNSTDY 583
L ++ G + + E G N S GQ+Q L RA+ + I + D+ ++VD
Sbjct: 745 ALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGK 804
Query: 584 ILLKTI---RTEFADCTVITVAHRIPTVMDCTMVLSINDGNLS 623
+ + + + + T I V H + + +++ ++ G +S
Sbjct: 805 HIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
>MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1528
Score = 391 bits (1004), Expect = e-108
Identities = 238/665 (35%), Positives = 361/665 (53%), Gaps = 46/665 (6%)
Query: 1 MSEGVIQQEGPYQQLL----------------------------ATSKEFQDLVNAHKVT 32
MS G I + G YQ+LL + KE + + N VT
Sbjct: 841 MSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVT 900
Query: 33 DGSNQLVNVTFSRASIKITQTLVENKG-----KEANGNQLIKQEEREKGDKGLKPYLQYL 87
D + + S +S T ++ K + K E +K G Y
Sbjct: 901 DTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYW 960
Query: 88 NQMKGYIFFFVASLGHFIFL---VCQILQNLWMAANVDNPRV-------STFQLIFVYFL 137
N MK I F+ L F+FL V + N W++ D+P V F+L VY
Sbjct: 961 NYMKA-IGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLS-VYGA 1018
Query: 138 LGASSAFFMLTRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELS 197
LG + S+ V G+ +S+ L L L+ ++ R+PM F++ TP G +++R S EL
Sbjct: 1019 LGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELD 1078
Query: 198 IMDLDIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVM 257
+D IP + +G+ + + + + T ++ P+ + +QR+Y AS++++
Sbjct: 1079 TVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLK 1138
Query: 258 RITGTTKSYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQ 317
R+ ++S V +H ET+ G IR FEE++RF ++ +D N +++ + +N WL
Sbjct: 1139 RLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAV 1198
Query: 318 RLETISAGVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIIS 377
RLE + ++ AAL VI + ++G +G+++SY L + ++L ++ + I++
Sbjct: 1199 RLECVGNCIVLFAALFAVI-SRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVA 1257
Query: 378 VERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVG 437
VERL +Y + EA ++ PP WP +G+VE D +RYR D LVL I T E G
Sbjct: 1258 VERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGG 1317
Query: 438 HKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLF 497
K+GIVGRTG+GKS+L LFR+ E + G IIIDGV+I+ IGLH+LR + IIPQDP LF
Sbjct: 1318 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLF 1377
Query: 498 TGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCL 557
+G++R NLDP SQYSD+E+W L L+ V + LN E G N S+GQRQL CL
Sbjct: 1378 SGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCL 1437
Query: 558 GRALLRRSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSI 617
RALLR+++ILVLDEATA+VD TD ++ TIRT+F DCTV+T+AHR+ T+MD T V+ +
Sbjct: 1438 ARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1497
Query: 618 NDGNL 622
+ G +
Sbjct: 1498 DKGEV 1502
Score = 60.1 bits (144), Expect = 2e-08
Identities = 57/254 (22%), Positives = 111/254 (43%), Gaps = 24/254 (9%)
Query: 376 ISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFE 435
+S++RL ++ + + +E R + + + + + P L+GIT +
Sbjct: 612 VSLKRLRIFLSHEELEPDSIE--RRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIP 669
Query: 436 VGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPT 495
G + +VG+ G GKS+L+SAL ++ G++ + G +PQ
Sbjct: 670 EGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKG-------------SVAYVPQQAW 716
Query: 496 LFTGTVRYNL---DPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQR 552
+ ++R N+ PL + + + E C L ++ G + + E G N S GQ+
Sbjct: 717 IQNDSLRENILFGHPLQENYYKAVMEA---CALLPDLEILPSGDRTEIGEKGVNLSGGQK 773
Query: 553 QLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTE--FADCTVITVAHRIPTVM 609
Q L RA+ S I + D+ ++VD + +I K + + T I V H I +
Sbjct: 774 QRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLP 833
Query: 610 DCTMVLSINDGNLS 623
+++ ++ G +S
Sbjct: 834 QVDVIIVMSGGKIS 847
>YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c
Length = 1478
Score = 367 bits (942), Expect = e-101
Identities = 220/596 (36%), Positives = 332/596 (54%), Gaps = 25/596 (4%)
Query: 43 FSRASIK----ITQTLVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFV 98
+ +A+IK I + L + +A G E+ E+G K Y Y ++ F
Sbjct: 865 YPKATIKGTGRIRKRLTDEDNVKATGQAA---EKMERGKVKWKVYWTYFKACSLFLIFL- 920
Query: 99 ASLGHFIFLVCQILQNL--------WMAANVD---NPRVSTFQLIFVYFLLGASSAFFML 147
+F+F++ I N+ W N NP+ + I+ F L S A L
Sbjct: 921 ----YFLFIIGGIGMNVGTNVWLKHWSEVNTQLGYNPKPYFYLGIYTLFGL-LSCALISL 975
Query: 148 TRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSL 207
+ + ++S +YL ++ ++ RAPM F++ TP GRIL+R SS++ +D I
Sbjct: 976 SSLTITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVISRVF 1035
Query: 208 TFAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYV 267
F L V + +I+ +P+ ++ Q YY +++E+ R+ T+S +
Sbjct: 1036 MFFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPL 1095
Query: 268 ANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVL 327
H E++ G TIR ++ ED F +N +D N +F F+SN W R+E I A V+
Sbjct: 1096 YAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLYFSSNRWQAIRVEAIGALVV 1155
Query: 328 ASAALCMVILPP-GTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMH 386
S+A V+ G SG +G++LSY + + L ++ + I+SVER+ +Y+
Sbjct: 1156 FSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTFVVRQSVDVETNIVSVERMLEYIG 1215
Query: 387 IQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRT 446
+ SEA I+ +RPP WP G ++ + +RYR + PLVL+ I+ + KIGIVGRT
Sbjct: 1216 LPSEAPSIIPDHRPPEGWPSHGAIKFDHYSVRYRENLPLVLNDISVNIKPQEKIGIVGRT 1275
Query: 447 GSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLD 506
G+GKSTL ALFRL+EP+ G+I +D ++I+SIGLHDLRSR IIPQ+ F GT+R NLD
Sbjct: 1276 GAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLD 1335
Query: 507 PLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSR 566
P + +D+EIW L L++ +Q D GL S V E G+N S GQRQL CL RALL +R
Sbjct: 1336 PNANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTR 1395
Query: 567 ILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
+L+LDEATA+VD TD I+ +TIR F D T++T+AHRI TVMD +L ++ G +
Sbjct: 1396 VLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAHRINTVMDSNRILVLDHGKV 1451
Score = 46.6 bits (109), Expect = 2e-04
Identities = 44/188 (23%), Positives = 83/188 (43%), Gaps = 24/188 (12%)
Query: 442 IVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTV 501
IVG+ G GKS+L+ A ++ G++ G Q P + T+
Sbjct: 629 IVGKVGMGKSSLLEACLGNMQKHSGSVFRCG-------------SIAYAAQQPWILNATI 675
Query: 502 RYNLDPLSQYSDQEIWE--VLGKCQLR--EVVQEKDEGLNSSVVEDGSNWSMGQRQLFCL 557
+ N+ D E +E + C LR E++ + D+ + V E G + S GQ+ L
Sbjct: 676 QENI-LFGLELDPEFYEKTIRACCLLRDFEILADGDQ---TEVGEKGISLSGGQKARISL 731
Query: 558 GRALLRRSRILVLDEATASVDNSTDYILLKTI---RTEFADCTVITVAHRIPTVMDCTMV 614
RA+ RS I +LD+ ++VD + L++ + + VI + + + + +M+
Sbjct: 732 ARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMI 791
Query: 615 LSINDGNL 622
+ +G +
Sbjct: 792 YMLRNGKI 799
>MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4
(MRP/cMOAT-related ABC transporter) (Multi-specific
organic anion tranporter-B) (MOAT-B)
Length = 1325
Score = 365 bits (938), Expect = e-100
Identities = 219/651 (33%), Positives = 364/651 (55%), Gaps = 33/651 (5%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQDLV------NAHKVTDGSNQLVNVTFSRASIKITQT- 53
+ +G + Q+G Y + L + +F L+ + G+ L N TFS +S+ Q+
Sbjct: 606 LKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSS 665
Query: 54 -------LVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIF 106
+E++ E N + +E R +G G + Y Y +I F L +
Sbjct: 666 RPSLKDGALESQDTE-NVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA 724
Query: 107 LVCQILQNLWMA--ANVDN-------------PRVSTFQLIFVYFLLGASSAFFMLTRSL 151
V +LQ+ W++ AN + ++ + +Y L ++ F + RSL
Sbjct: 725 QVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSL 784
Query: 152 FVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAV 211
V + + SS+ L ++ S+ +AP+ F+D P+GRIL+R S ++ +D +P + +
Sbjct: 785 LVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844
Query: 212 GTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHV 271
T + ++V V + I +P+ I I L+RY+ ++++V R+ TT+S V +H+
Sbjct: 845 QTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHL 904
Query: 272 AETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAA 331
+ ++ G TIR ++ E+R + D+++ ++F ++ W RL+ I A + A
Sbjct: 905 SSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA 964
Query: 332 LCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEA 391
+IL T +G +G+ALSY L L ++ + N +ISVER+ +Y ++ EA
Sbjct: 965 FGSLILAK-TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEA 1023
Query: 392 KEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKS 451
+ RPP WP G + +++ Y P GPLVL +T + K+GIVGRTG+GKS
Sbjct: 1024 PWEYQ-KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKS 1082
Query: 452 TLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQY 511
+LISALFRL EP G I ID + + IGLHDLR + IIPQ+P LFTGT+R NLDP ++
Sbjct: 1083 SLISALFRLSEPEG-KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFKEH 1141
Query: 512 SDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLD 571
+D+E+W L + QL+E +++ +++ + E GSN+S+GQRQL CL RA+LR+++IL++D
Sbjct: 1142 TDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIID 1201
Query: 572 EATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
EATA+VD TD ++ K IR +FA CTV+T+AHR+ T++D ++ ++ G L
Sbjct: 1202 EATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRL 1252
Score = 80.1 bits (196), Expect = 2e-14
Identities = 102/481 (21%), Positives = 210/481 (43%), Gaps = 69/481 (14%)
Query: 183 TPLGRILSRVSSELSIMDLDIPFSLTF-------AVGTTMNFYSTLTVFSVVTWQVLIVA 235
T G+I++ +S++++ D + L F A+ T + + + + VLI+
Sbjct: 189 TTTGQIVNLLSNDVNKFD-QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIIL 247
Query: 236 IPM------VYITIRLQRYYFASAK-----EVMRITGTTKSYVANHVAETVSGAVTIRTF 284
+P+ ++ ++R + F A+ EV+ K Y ++ S +T
Sbjct: 248 LPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWE---KSFSNLITNLRK 304
Query: 285 EEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVILPPGTFTS 344
+E + + + L +N +SFF ++ ++ +L T+
Sbjct: 305 KEISKILRSSC-LRGMNLASFFS---------------ASKIIVFVTFTTYVLLGSVITA 348
Query: 345 GFIGMALS-YG---LALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRP 400
+ +A++ YG L + F ++I+ ++ I+S+ R+ ++ + EI + NR
Sbjct: 349 SRVFVAVTLYGAVRLTVTLFFPSAIER---VSEAIVSIRRIQTFLLLD----EISQRNR- 400
Query: 401 PLNWPIAGK--VEINDLKIRY-RPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISAL 457
P GK V + D + + L G++ T G + +VG G+GKS+L+SA+
Sbjct: 401 --QLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAV 458
Query: 458 FRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIW 517
+ PS G + + G R + Q P +F+GT+R N+ +Y +
Sbjct: 459 LGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYE 505
Query: 518 EVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASV 577
+V+ C L++ +Q ++G + + + G+ S GQ+ L RA+ + + I +LD+ ++V
Sbjct: 506 KVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAV 565
Query: 578 DNSTDYILLKTIRTEFA-DCTVITVAHRIPTVMDCTMVLSINDGNLSRNTGLIFSLQSHI 636
D L + + + I V H++ + + +L + DG + + L+S I
Sbjct: 566 DAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGI 625
Query: 637 D 637
D
Sbjct: 626 D 626
>MRP3_HUMAN (O15438) Canalicular multispecific organic anion
transporter 2 (Multidrug resistance-associated protein 3)
(Multi-specific organic anion tranporter-D) (MOAT-D)
Length = 1527
Score = 363 bits (933), Expect = e-100
Identities = 199/512 (38%), Positives = 307/512 (59%), Gaps = 6/512 (1%)
Query: 114 NLWMAA-----NVDNPRVSTFQLIFVYFLLGASSAFFMLTRSLFVIALGLQSSKYLFLQL 168
N+W++A D+ + +T + VY LG F ++ ++ + A G+Q+++ L L
Sbjct: 989 NVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQAL 1048
Query: 169 MNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNFYSTLTVFSVVT 228
+++ R+P F+D TP GRIL+ S ++ ++D + + + + N STL V T
Sbjct: 1049 LHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAST 1108
Query: 229 WQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGAVTIRTFEEED 288
+V +P+ + +QR+Y A+++++ R+ ++S + +H +ETV+GA IR +
Sbjct: 1109 PLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSR 1168
Query: 289 RFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVILPPGTFTSGFIG 348
F + +D N S + SN WL +E + V+ AAL VI + G +G
Sbjct: 1169 DFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVI-GRSSLNPGLVG 1227
Query: 349 MALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAG 408
+++SY L + L I+ L + I++VER+ +Y ++EA +VEG+RPP WP G
Sbjct: 1228 LSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRG 1287
Query: 409 KVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNI 468
+VE + +RYRP LVL ++ G K+GIVGRTG+GKS++ LFR++E + G I
Sbjct: 1288 EVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEI 1347
Query: 469 IIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREV 528
IDG++++ IGLHDLRS+ IIPQDP LF+GT+R NLDP YS+++IW L L
Sbjct: 1348 RIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTF 1407
Query: 529 VQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNSTDYILLKT 588
V + GL+ E G N S+GQRQL CL RALLR+SRILVLDEATA++D TD ++ T
Sbjct: 1408 VSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQAT 1467
Query: 589 IRTEFADCTVITVAHRIPTVMDCTMVLSINDG 620
IRT+F CTV+T+AHR+ T+MD T VL ++ G
Sbjct: 1468 IRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKG 1499
Score = 63.2 bits (152), Expect = 2e-09
Identities = 66/281 (23%), Positives = 119/281 (41%), Gaps = 22/281 (7%)
Query: 346 FIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLNWP 405
F+ ++L L L ++ + S T A+ +S++R+ Q++ + + VE +
Sbjct: 569 FVSVSLFNILRLPLNMLPQLISNLTQAS--VSLKRIQQFLSQEELDPQSVERKTISPGYA 626
Query: 406 IAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSG 465
I I+ + D P LH + G + +VG G GKS+L+SAL +E
Sbjct: 627 IT----IHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLE 682
Query: 466 GNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQL 525
G + ++ +PQ + T++ N+ + + + L C L
Sbjct: 683 GKV-------------HMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACAL 729
Query: 526 REVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNS-TDYI 584
++ G + + E G N S GQRQ L RA+ + I +LD+ ++VD+ +I
Sbjct: 730 LADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHI 789
Query: 585 LLKTIRTE--FADCTVITVAHRIPTVMDCTMVLSINDGNLS 623
I E A T + V H I + ++ + DG +S
Sbjct: 790 FDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVS 830
>MRP3_RAT (O88563) Canalicular multispecific organic anion transporter
2 (Multidrug resistance-associated protein 3) (MRP-like
protein-2) (MLP-2)
Length = 1522
Score = 357 bits (916), Expect = 6e-98
Identities = 205/559 (36%), Positives = 320/559 (56%), Gaps = 7/559 (1%)
Query: 67 LIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFLVCQILQNLWMAANVDN--- 123
LIK+E E G+ L Y Y + F+ L V I N+W++A ++
Sbjct: 938 LIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICLLYAGQNAVA-IGANVWLSAWTNDVEE 996
Query: 124 --PRVSTFQLIFVYFLLGASSAFFMLTRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYD 181
+ +T + VY LG ++ + ++ +Q+++ L L+++ RAP F+D
Sbjct: 997 HGQQNNTSVRLGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFD 1056
Query: 182 CTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYI 241
TP GRIL+R S ++ ++ + ++ + ST+ V T +V +P+
Sbjct: 1057 TTPSGRILNRFSKDIYVIHEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVF 1116
Query: 242 TIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDIN 301
+QR+Y A+++++ R+ ++S + +H +ETV+G IR + F + +D N
Sbjct: 1117 YGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSN 1176
Query: 302 ASSFFHNFASNEWLIQRLETISAGVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFL 361
+ + ASN WL +E + V+ +AL VI + G +G+++SY L + L
Sbjct: 1177 QKTTYPYIASNRWLGVHVEFVGNCVVLFSALFAVI-GRNSLNPGLVGLSVSYALQVTLSL 1235
Query: 362 VNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRP 421
I++ L + II+VER+ +Y ++EA ++E NR P WP +G VE + +RYRP
Sbjct: 1236 NWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGVVEFRNYSVRYRP 1295
Query: 422 DGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLH 481
LVL +T + G K+GIVGRTG+GKS++ LFR++E + G I IDG++++ IGLH
Sbjct: 1296 GLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLH 1355
Query: 482 DLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVV 541
DLRS+ IIPQDP LF+GT+R NLDP +YSD++IW L L V + GL+
Sbjct: 1356 DLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCS 1415
Query: 542 EDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITV 601
E G N S+GQRQL CL RALLR+SR+LVLDEATA++D TD ++ TIRT+F DCTV+T+
Sbjct: 1416 EGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTI 1475
Query: 602 AHRIPTVMDCTMVLSINDG 620
AHR+ T+MD VL ++ G
Sbjct: 1476 AHRLNTIMDYNRVLVLDKG 1494
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/217 (24%), Positives = 92/217 (41%), Gaps = 16/217 (7%)
Query: 410 VEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNII 469
+ I++ + D P LH I G + +VG G GKS+L+SAL +E G +
Sbjct: 625 ITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVS 684
Query: 470 IDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVV 529
+ G +PQ + T++ N+ + + + L C L +
Sbjct: 685 VKG-------------SVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADL 731
Query: 530 QEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVDNS-TDYILLKT 588
G + + E G N S GQRQ L RA+ + I +LD+ ++VD+ +I +
Sbjct: 732 DVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQV 791
Query: 589 IRTE--FADCTVITVAHRIPTVMDCTMVLSINDGNLS 623
I E A T + V H I + ++ + DG ++
Sbjct: 792 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQIT 828
>ACC9_RAT (Q63563) Sulfonylurea receptor 2
Length = 1545
Score = 352 bits (904), Expect = 1e-96
Identities = 215/646 (33%), Positives = 360/646 (55%), Gaps = 30/646 (4%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQD----LVNAH-KVTDGSNQLVNVTFSRASIKITQTLV 55
M +G + +EG + + E + L+N + + + T R +++
Sbjct: 881 MKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSR 940
Query: 56 ENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFLVCQILQNL 115
E K + + ++ ++EE E D + ++ +M ++ + G F L I L
Sbjct: 941 EAKAQMEDEDE--EEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKL 998
Query: 116 -----------WMAA-----NVDNPRVS--TFQLIFVYFLLGASSAFFMLTRSLFVIALG 157
W+A ++++P + TF + L GA F L SL V +G
Sbjct: 999 LKHSVIVAIDYWLATWTSEYSINDPGKADQTFYVAGFSILCGAG-IFLCLVTSLTVEWMG 1057
Query: 158 LQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNF 217
L ++K L L+N + P+ F+D TPLG IL+R S++ +I+D IP +L +T+
Sbjct: 1058 LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLC 1117
Query: 218 YSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSG 277
S + + S T LI P+ +Q+Y+ ++K++ + +T+ + H +ET G
Sbjct: 1118 LSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEG 1177
Query: 278 AVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVIL 337
TIR F E RF Q+ L+L D N ++ A+N WL R + + A ++ +A++ +
Sbjct: 1178 LTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI-- 1235
Query: 338 PPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKE-IVE 396
G+ SG +G+ L Y L + ++L +++ L Q+ +V+++N ++ ++SE E ++
Sbjct: 1236 -SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMD 1294
Query: 397 GNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISA 456
++ P +WP G+++I+DL +RY + VL + + G K+GI GRTGSGKS+L A
Sbjct: 1295 PSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLA 1354
Query: 457 LFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEI 516
FR+V+ G I+IDG+DIS + LH LRSR II QDP LF+G++R+NLDP + +D +
Sbjct: 1355 FFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRL 1414
Query: 517 WEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATAS 576
WE L QL+ +V+ GL+++V E G N+S+GQRQLFCL RA +R+S IL++DEATAS
Sbjct: 1415 WEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATAS 1474
Query: 577 VDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
+D +T+ IL K + T FAD TV+T+AHR+ ++MD +VL ++G L
Sbjct: 1475 IDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGIL 1520
Score = 79.0 bits (193), Expect = 4e-14
Identities = 84/339 (24%), Positives = 147/339 (42%), Gaps = 47/339 (13%)
Query: 346 FIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYM---HIQSEAKEIVEGNRP-- 400
F ++L + L FL++++ A IISV++LN+++ I ++ EG P
Sbjct: 569 FASLSLFHILVTPLFLLSTVVRFAVKA--IISVQKLNEFLLSDEIGEDSWRTGEGTLPFE 626
Query: 401 -----------PLNWPIAGKVEINDLKI--RYRP------------------DGPLVLHG 429
P+N G+ +++ + R RP G L
Sbjct: 627 SCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLATLSN 686
Query: 430 ITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSR--- 486
I G IVG+ G GKS+L+ A+ ++ G + + V+ S RSR
Sbjct: 687 IDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRY 746
Query: 487 -FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGS 545
Q P L TV N+ S ++ Q V C L+ + G + + E G
Sbjct: 747 SVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGI 806
Query: 546 NWSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFAD--CTVITVA 602
N S GQRQ C+ RAL + + I+ LD+ +++D + +D+++ + I D TV+ V
Sbjct: 807 NLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVT 866
Query: 603 HRIPTVMDCTMVLSINDGNLSRNTGLIFSLQSHIDVNNY 641
H++ + ++++ DG++ R G + +Q+ DV Y
Sbjct: 867 HKLQYLTHADWIIAMKDGSVLRE-GTLKDIQTK-DVELY 903
>BPT1_YEAST (P14772) Bile pigment transporter 1
Length = 1559
Score = 352 bits (902), Expect = 2e-96
Identities = 231/664 (34%), Positives = 358/664 (53%), Gaps = 59/664 (8%)
Query: 14 QLLATSKEFQDLVNAHKVTDGSNQLVNVTFSRASIKITQ------TLVENKGKEANGNQL 67
QL T E +D V VT+ +L+ RAS+ + +++ K A
Sbjct: 902 QLKVTESETEDEV----VTESELELIKANSRRASLATLRPRPFVGAQLDSVKKTAQ---- 953
Query: 68 IKQEEREKGDKGLKPYLQYLNQ--MKGYIFFFVASLGHFIFLVCQILQNLWMA------- 118
K E+ E G K YL Y+ + G + FF+ + +F + +N W+
Sbjct: 954 -KAEKTEVGRVKTKIYLAYIKACGVLGVVLFFLFMILTRVF---DLAENFWLKYWSESNE 1009
Query: 119 ANVDNPRVSTFQLIFVYFLLGASSAFFMLTRSLFVIAL-GLQSSKYLFLQLMNSLFRAPM 177
N N RV F + VY L+G +SA F RS+ ++ ++ SK L + S+ R+PM
Sbjct: 1010 KNGSNERVWMF--VGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPM 1067
Query: 178 PFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIVAIP 237
F++ TP+GRI++R SS++ +D ++ + +F + + + T+ + L+ +
Sbjct: 1068 TFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMF 1127
Query: 238 MVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGAVTIRTFEEEDRFFQKNLDL 297
+V I I Q +Y ++E+ R+ + S + + ++E+++G I ++ +RF N +
Sbjct: 1128 LVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEK 1187
Query: 298 IDINASSFFHNFASNEWLIQRLETISAG-VLASAALCMVIL-PPGTFTSGFIGMALSYGL 355
I N F+ ++N WL RL+TI A VLA+A L + + +SG +G+ +SY L
Sbjct: 1188 IQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSL 1247
Query: 356 ALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDL 415
+ L +++ T+ I+SVER+ +Y + EA+ I RP NWP G +E +
Sbjct: 1248 EVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNY 1307
Query: 416 KIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDI 475
+YR + VL+ I E K+GIVGRTG+GKSTL ALFR++EP+ G IIIDG+DI
Sbjct: 1308 STKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDI 1367
Query: 476 SSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLR----EVVQE 531
S IGL DLRS IIPQD F GTV+ NLDP ++YS+ E+ + + L+ +++
Sbjct: 1368 SDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHS 1427
Query: 532 KDEG-------------LNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVD 578
K G L+ + E+GSN S+GQRQL CL RALL RS+ILVLDEATASVD
Sbjct: 1428 KPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVD 1487
Query: 579 NSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGN----------LSRNTGL 628
TD I+ TIR EF D T++T+AHRI TV+D ++ ++ G+ LS T +
Sbjct: 1488 METDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSI 1547
Query: 629 IFSL 632
+SL
Sbjct: 1548 FYSL 1551
Score = 50.1 bits (118), Expect = 2e-05
Identities = 49/193 (25%), Positives = 90/193 (46%), Gaps = 15/193 (7%)
Query: 437 GHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTL 496
G + +VGR G+GKST + A+ + G+ D L S Q+ +
Sbjct: 665 GDLVCVVGRVGAGKSTFLKAILGQLPCMSGSR-----DSIPPKLIIRSSSVAYCSQESWI 719
Query: 497 FTGTVRYNLDPLSQYSDQEIWEVLGK-CQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLF 555
+VR N+ DQ+ +++ K CQL ++ +G + V E G + S GQ+
Sbjct: 720 MNASVRENI-LFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARL 778
Query: 556 CLGRALLRRSRILVLDEATASVD-----NSTDYILL-KTIRTEFADCTVITVAHRIPTVM 609
L RA+ R+ I +LD+ ++VD N +Y+L+ KT + + T+I + + +
Sbjct: 779 SLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLK--NKTIILTTNTVSILK 836
Query: 610 DCTMVLSINDGNL 622
M+ ++ +G +
Sbjct: 837 HSQMIYALENGEI 849
>MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5
Length = 1436
Score = 350 bits (899), Expect = 5e-96
Identities = 213/659 (32%), Positives = 346/659 (52%), Gaps = 47/659 (7%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQDL-------------VNAHKVTDGSNQLVNVTFSRAS 47
M EG I + G +++L+ + ++ + +N+ K GS + + S
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEASGSQKSQDKGPKPGS 815
Query: 48 IKITQTLVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFL 107
+K + K ++ QL++ EE+ +G Y Y+ G + F V + + +
Sbjct: 816 VK------KEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNV 869
Query: 108 VCQILQNLWMAANV----------------------DNPRVSTFQLIFVYFLLGASSAFF 145
W++ + DNP + + I Y L A
Sbjct: 870 GSTAFSTWWLSYWIKQGSGNSTVFEGNRSSVSDSMRDNPFLQYYASI--YALSMAVMLIL 927
Query: 146 MLTRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPF 205
R + + L++S L +L + R+PM F+D TP GRIL+R S ++ +D+ +PF
Sbjct: 928 KAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPF 987
Query: 206 SLT-FAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTK 264
F + F+ + V W ++ V P++ + L +E+ R+ T+
Sbjct: 988 QAEMFIQNVILVFFCVGMIAGVFPWFLVAVG-PLLILFSVLHIVSRVLIRELKRLDNITQ 1046
Query: 265 SYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISA 324
S +H+ ++ G TI + + F + +L+D N + FF + WL RL+ IS
Sbjct: 1047 SPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISI 1106
Query: 325 GVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQY 384
++ + L M++L G S + G+A+SY + L +++ + SVER+N Y
Sbjct: 1107 ALITTTGL-MIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHY 1165
Query: 385 MHIQS-EAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIV 443
+ S EA ++ PP +WP G++ + ++RYR + PLVL ++ T + KIGIV
Sbjct: 1166 IKTLSLEAPARIKNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIKPKEKIGIV 1225
Query: 444 GRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRY 503
GRTGSGKS+L ALFRLVE SGG I IDGV IS IGL DLRS+ IIPQ+P LF+GTVR
Sbjct: 1226 GRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEPVLFSGTVRS 1285
Query: 504 NLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLR 563
NLDP +QY++++IW+ L + ++E + + L S V+E+G N+S+G+RQL C+ RALLR
Sbjct: 1286 NLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLR 1345
Query: 564 RSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
+IL+LDEATA++D TD ++ +TIR FADCT++T+AHR+ TV+ ++ + G +
Sbjct: 1346 HCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQV 1404
Score = 78.2 bits (191), Expect = 6e-14
Identities = 55/195 (28%), Positives = 91/195 (46%), Gaps = 14/195 (7%)
Query: 427 LHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSR 486
L+ I E G +GI G GSGK++LISA+ + G+I + G
Sbjct: 578 LYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGT------------- 624
Query: 487 FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSN 546
F + Q + T+R N+ ++ ++ VL C LR + + + E G+N
Sbjct: 625 FAYVAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGAN 684
Query: 547 WSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFADCTVITVAHRI 605
S GQRQ L RAL I +LD+ +++D + ++I IR TV+ V H++
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQL 744
Query: 606 PTVMDCTMVLSINDG 620
++DC V+ + +G
Sbjct: 745 QYLVDCDEVIFMKEG 759
>ACC9_HUMAN (O60706) Sulfonylurea receptor 2
Length = 1549
Score = 350 bits (897), Expect = 9e-96
Identities = 212/645 (32%), Positives = 357/645 (54%), Gaps = 28/645 (4%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQD----LVNAH-KVTDGSNQLVNVTFSRASIKITQTLV 55
M +G + +EG + + E + L+N + + + T R +++
Sbjct: 885 MKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSR 944
Query: 56 ENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFLVCQILQNL 115
E K + + ++ ++EE E D + ++ +M + + G F L+ I L
Sbjct: 945 EAKAQMEDEDE--EEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKL 1002
Query: 116 -----------WMAANVDNPRVS-TFQLIFVYFLLGAS-----SAFFMLTRSLFVIALGL 158
W+A ++ T + Y++ G S F L SL V +GL
Sbjct: 1003 LKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGL 1062
Query: 159 QSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNFY 218
++K L L+N + P+ F+D TPLG IL+R S++ +I+D IP +L +T+
Sbjct: 1063 TAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCL 1122
Query: 219 STLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGA 278
S + + S T L+ +P+ +Q+Y+ ++K++ + +T+ + H +ET G
Sbjct: 1123 SAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGL 1182
Query: 279 VTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVILP 338
TIR F E RF Q+ L+L D N ++ A+N WL R + + A ++ +A++ +
Sbjct: 1183 TTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI--- 1239
Query: 339 PGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKE-IVEG 397
G+ SG +G+ L Y L + ++L +++ L Q+ +V+++N ++ ++SE E ++
Sbjct: 1240 SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDP 1299
Query: 398 NRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISAL 457
++ P +WP G+++I+DL +RY + VL + + G K+GI GRTGSGKS+L A
Sbjct: 1300 SQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAF 1359
Query: 458 FRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIW 517
FR+V+ G I+IDG+DIS + LH LRSR II QDP LF+G++R+NLDP + +D +W
Sbjct: 1360 FRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLW 1419
Query: 518 EVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASV 577
E L QL+ +V+ GL++ V E G N+S+GQRQLFCL RA +R+S IL++DEATAS+
Sbjct: 1420 EALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASI 1479
Query: 578 DNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
D +T+ IL K + T FAD TV+T+AHR+ ++MD +VL ++G L
Sbjct: 1480 DMATENILQKVVMTAFADRTVVTMAHRVSSIMDAGLVLVFSEGIL 1524
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/226 (26%), Positives = 104/226 (45%), Gaps = 9/226 (3%)
Query: 423 GPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHD 482
G L I G IVG+ G GKS+L+ A+ ++ G + V+ S
Sbjct: 684 GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEA 743
Query: 483 LRSR----FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNS 538
RSR Q P L TV N+ S ++ Q V C L+ + G +
Sbjct: 744 TRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQT 803
Query: 539 SVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFAD-- 595
+ E G N S GQRQ C+ RAL + + I+ LD+ +++D + +D+++ + I D
Sbjct: 804 EIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDK 863
Query: 596 CTVITVAHRIPTVMDCTMVLSINDGNLSRNTGLIFSLQSHIDVNNY 641
T++ V H++ + ++++ DG++ R G + +Q+ DV Y
Sbjct: 864 RTLVLVTHKLQYLTHADWIIAMKDGSVLRE-GTLKDIQTK-DVELY 907
>YH85_SCHPO (Q9P5N0) Probable ATP-dependent permease C359.05
Length = 1465
Score = 349 bits (895), Expect = 2e-95
Identities = 220/662 (33%), Positives = 350/662 (52%), Gaps = 40/662 (6%)
Query: 1 MSEGVIQQEGPYQQLLATSK--------EFQDLVNAHKVTDGSNQLVNVTFSRA-SIKIT 51
+S G I ++G Y+ L ++ EF D + + + + + S A SI +
Sbjct: 777 LSNGKIVEKGNYEHLFVSTNSELKQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHVE 836
Query: 52 QTLVENKGKEANGNQLIKQEERE-------KGDKGL----KPYLQYLNQMKGYIF---FF 97
+ + + + K +R + DKG L ++K +++ F
Sbjct: 837 GLETYSSSERKDSSNKYKSRKRNPIRQKVTEDDKGKCVAQTDELVQRGKVKWHVYWMYFK 896
Query: 98 VASLG----HFIFLVCQILQNL--------WMAANVDNP---RVSTFQLIFVYFLLGASS 142
S+G +F F++ I+ N+ W N + S + + +Y G S
Sbjct: 897 SCSIGLILLYFFFIISGIMMNVATNVWLKHWSEENGKSSSELNPSPYFYLGIYLFFGFLS 956
Query: 143 AFFMLTRSLFVIAL-GLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDL 201
F+ + SL + L G++S +YL ++ ++ RAPM F++ T GRIL+R S+++ +D
Sbjct: 957 CAFISSSSLTMTVLCGIRSGRYLHDSMLKTILRAPMGFFETTSSGRILNRFSNDVYKVDE 1016
Query: 202 DIPFSLTFAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITG 261
+ + F ++ L V L++ +P+ ++ + + YY +++E+ R+
Sbjct: 1017 VVSLTFMFFFRNSIQVLFILGVICYSAPLSLLLIVPLFFLYLYNRAYYVRTSRELKRLDN 1076
Query: 262 TTKSYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLET 321
T+S + HV E++SG TIR + ++ F ++N ID N +F F+S+ W R+E
Sbjct: 1077 VTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMFFSSSRWQAIRVEC 1136
Query: 322 ISAGVLASAALCMVILP-PGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVER 380
I ++ A ++ G+ G +G +LSY + + L +Q N +SVER
Sbjct: 1137 IGDLIIFCTAFYGILSAIKGSPNPGLVGFSLSYAIQITQGLSFIVQQSVDAENNTVSVER 1196
Query: 381 LNQYMHIQSEAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKI 440
+ +Y++++SEA EI+ NRPP WP G V N +YR D L+ I KI
Sbjct: 1197 ILEYINVKSEAPEIIPENRPPCEWPTDGAVSFNHYSAKYREDLSFALNNINIEISPREKI 1256
Query: 441 GIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGT 500
GIVGRTG+GKSTL ALFR++EP+ G I ID DI+ GL+DLRSR IIPQ+ +F G
Sbjct: 1257 GIVGRTGAGKSTLAMALFRIIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGN 1316
Query: 501 VRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRA 560
+R NLDP + +D++IWEVL L+ + + ++GL S V E G+N+S GQRQL CL R
Sbjct: 1317 IRENLDPNHRLTDKKIWEVLEIASLKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARV 1376
Query: 561 LLRRSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDG 620
LL +RIL+LDEATASV TD I+ +TIR F D T++TVAHRI TVMD +L ++ G
Sbjct: 1377 LLTSTRILLLDEATASVHAETDAIVQQTIRKRFKDRTILTVAHRINTVMDSDRILVLDHG 1436
Query: 621 NL 622
+
Sbjct: 1437 KV 1438
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/148 (25%), Positives = 68/148 (45%), Gaps = 13/148 (8%)
Query: 442 IVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTV 501
I G+ G+GKS+L+ A + + G++ G Q P +F T+
Sbjct: 612 IFGKVGAGKSSLLEACMGNMYKNSGSVFQCG-------------SLAYAAQQPWIFDATI 658
Query: 502 RYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRAL 561
R N+ S++ + + + C L+ + EG + V + G++ S GQ+ L RA+
Sbjct: 659 RENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQKSRISLARAI 718
Query: 562 LRRSRILVLDEATASVDNSTDYILLKTI 589
++ I +LD+ +SVD L+K +
Sbjct: 719 YSQADIYLLDDVLSSVDQHVSRDLIKNL 746
>ACC9_MOUSE (P70170) Sulfonylurea receptor 2
Length = 1546
Score = 349 bits (895), Expect = 2e-95
Identities = 212/646 (32%), Positives = 360/646 (54%), Gaps = 30/646 (4%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQD----LVNAH-KVTDGSNQLVNVTFSRASIKITQTLV 55
M +G + +EG + + E + L+N + + + T R +++
Sbjct: 882 MKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSR 941
Query: 56 ENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFLVCQILQNL 115
E K + + ++ ++EE E + + ++ +M ++ + G F L I L
Sbjct: 942 EAKAQMEDEDE--EEEEEEDEEDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKL 999
Query: 116 -----------WMAA-----NVDNPRVS--TFQLIFVYFLLGASSAFFMLTRSLFVIALG 157
W+A ++++P + TF + L GA F L SL V +G
Sbjct: 1000 LKHSVIVAIDYWLATWTSEYSINHPGKADQTFYVAGFSILCGAG-IFLCLVTSLTVEWMG 1058
Query: 158 LQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNF 217
L ++K L L+N + P+ F+D TPLG IL+R S++ +I+D IP +L +T+
Sbjct: 1059 LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLC 1118
Query: 218 YSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSG 277
S + + S T L+ P+ +Q+Y+ ++K++ + +T+ + H +ET G
Sbjct: 1119 LSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEG 1178
Query: 278 AVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVIL 337
TIR F E RF Q+ L+L D N ++ A+N WL R + + A ++ +A++ +
Sbjct: 1179 LTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI-- 1236
Query: 338 PPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKE-IVE 396
G+ SG +G+ L Y L + ++L +++ L Q+ +V+++N ++ ++SE E ++
Sbjct: 1237 -SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMD 1295
Query: 397 GNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISA 456
++ P +WP G+++I+DL +RY + VL + + G K+GI GRTGSGKS+L A
Sbjct: 1296 PSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLA 1355
Query: 457 LFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEI 516
FR+V+ G I+IDG+DIS + LH LRSR II QDP LF+G++R+NLDP + +D +
Sbjct: 1356 FFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRL 1415
Query: 517 WEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATAS 576
WE L QL+ +V+ GL+++V E G N+S+GQRQLFCL RA +R+S IL++DEATAS
Sbjct: 1416 WEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATAS 1475
Query: 577 VDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
+D +T+ IL K + T FAD TV+T+AHR+ +++D +VL ++G L
Sbjct: 1476 IDMATENILQKVVMTAFADRTVVTIAHRVSSIVDAGLVLVFSEGIL 1521
Score = 78.2 bits (191), Expect = 6e-14
Identities = 84/339 (24%), Positives = 146/339 (42%), Gaps = 47/339 (13%)
Query: 346 FIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYM---HIQSEAKEIVEGNRP-- 400
F ++L + L FL++++ A IISV++LN+++ I ++ EG P
Sbjct: 570 FASLSLFHILVTPLFLLSTVVRFAVKA--IISVQKLNEFLLSDEIGEDSWRAGEGTLPFE 627
Query: 401 -----------PLNWPIAGKVEINDLKI--RYRP------------------DGPLVLHG 429
P+N G+ ++ + R RP G L
Sbjct: 628 SCKKHTGVQSKPINRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWGSGLATLSN 687
Query: 430 ITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSR--- 486
I G IVG+ G GKS+L+ A+ ++ G + + V+ S RSR
Sbjct: 688 IDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRY 747
Query: 487 -FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGS 545
Q P L TV N+ S ++ Q V C L+ + G + + E G
Sbjct: 748 SVAYAAQKPWLLNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGI 807
Query: 546 NWSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFAD--CTVITVA 602
N S GQRQ C+ RAL + + I+ LD+ +++D + +D+++ + I D TV+ V
Sbjct: 808 NLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVT 867
Query: 603 HRIPTVMDCTMVLSINDGNLSRNTGLIFSLQSHIDVNNY 641
H++ + ++++ DG++ R G + +Q+ DV Y
Sbjct: 868 HKLQYLTHADWIIAMKDGSVLRE-GTLKDIQTK-DVELY 904
>ACC9_RABIT (P82451) Sulfonylurea receptor 2
Length = 1549
Score = 348 bits (893), Expect = 3e-95
Identities = 211/645 (32%), Positives = 356/645 (54%), Gaps = 28/645 (4%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQD----LVNAH-KVTDGSNQLVNVTFSRASIKITQTLV 55
M +G + +EG + + E + L+N + + + T R +++
Sbjct: 885 MKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSR 944
Query: 56 ENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFLVCQILQNL 115
E K + + ++ ++EE E D + ++ +M + + G F L I L
Sbjct: 945 EAKAQMEDEDE--EEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKL 1002
Query: 116 -----------WMAANVDNPRVS-TFQLIFVYFLLGAS-----SAFFMLTRSLFVIALGL 158
W+A ++ T + Y++ G S F L SL V +GL
Sbjct: 1003 LKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGL 1062
Query: 159 QSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPFSLTFAVGTTMNFY 218
++K L L+N + P+ F+D TPLG IL+R S++ +I+D IP +L +T+
Sbjct: 1063 TAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCL 1122
Query: 219 STLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTKSYVANHVAETVSGA 278
S + + S T L+ +P+ +Q+Y+ ++K++ + +T+ + H +ET G
Sbjct: 1123 SAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGL 1182
Query: 279 VTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISAGVLASAALCMVILP 338
TIR F E RF Q+ L+L D N ++ A+N WL R + + A ++ +A++ +
Sbjct: 1183 TTIRAFRHEARFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASI--- 1239
Query: 339 PGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQYMHIQSEAKE-IVEG 397
G+ SG +G+ L Y L + ++L +++ L Q+ +V+++N ++ ++SE E ++
Sbjct: 1240 SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDP 1299
Query: 398 NRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISAL 457
++ P +WP G+++I+DL +RY + VL + + G K+GI GRTGSGKS+L A
Sbjct: 1300 SQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAF 1359
Query: 458 FRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRYNLDPLSQYSDQEIW 517
FR+V+ G I+IDG+DIS + LH LRSR II QDP LF+G++R+NLDP + +D +W
Sbjct: 1360 FRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLW 1419
Query: 518 EVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASV 577
E L QL+ +V+ GL++ V E G N+S+GQRQLFCL RA +R+S IL++DEATAS+
Sbjct: 1420 EALEIAQLKNMVKSLSGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASI 1479
Query: 578 DNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
D +T+ IL K + T FAD TV+T+AHR+ +++D +VL ++G L
Sbjct: 1480 DMATENILQKVVMTAFADRTVVTIAHRVSSIVDADLVLVFSEGIL 1524
Score = 71.2 bits (173), Expect = 8e-12
Identities = 59/226 (26%), Positives = 103/226 (45%), Gaps = 9/226 (3%)
Query: 423 GPLVLHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHD 482
G L I G IVG+ G GKS+L+ A+ ++ G + V+ S
Sbjct: 684 GAATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLDGKVHWSNVNESEPSFEA 743
Query: 483 LRSR----FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNS 538
RSR Q P L TV N+ S ++ Q V C L+ + G +
Sbjct: 744 TRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQT 803
Query: 539 SVVEDGSNWSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFAD-- 595
+ E G N S GQ + C+ RAL + + I+ LD+ +++D + +D+++ + I D
Sbjct: 804 EIGERGINLSGGQTERICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDK 863
Query: 596 CTVITVAHRIPTVMDCTMVLSINDGNLSRNTGLIFSLQSHIDVNNY 641
T++ V H++ + ++++ DG++ R G + +Q+ DV Y
Sbjct: 864 RTLVLVTHKLQYLTHADWIIAMKDGSVLRE-GTLKDIQTK-DVELY 907
>MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5
(Multi-specific organic anion tranporter-C) (MOAT-C)
(pABC11) (SMRP)
Length = 1437
Score = 346 bits (888), Expect = 1e-94
Identities = 214/659 (32%), Positives = 343/659 (51%), Gaps = 46/659 (6%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQDL-------------VNAHKVTDGSNQLVNVTFSRAS 47
M EG I + G +++L+ + ++ + +N+ K T GS + S+
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKK-----SQDK 810
Query: 48 IKITQTLVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFL 107
T ++ + K + QL++ EE+ +G Y Y+ G + F V + +
Sbjct: 811 GPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNV 870
Query: 108 VCQILQNLWMAANV----------------------DNPRVSTFQLIFVYFLLGASSAFF 145
W++ + DNP + + I Y L A
Sbjct: 871 GSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASI--YALSMAVMLIL 928
Query: 146 MLTRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPF 205
R + + L++S L +L + R+PM F+D TP GRIL+R S ++ +D+ +PF
Sbjct: 929 KAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPF 988
Query: 206 SLT-FAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTK 264
F + F+ + V W ++ V P+V + L +E+ R+ T+
Sbjct: 989 QAEMFIQNVILVFFCVGMIAGVFPWFLVAVG-PLVILFSVLHIVSRVLIRELKRLDNITQ 1047
Query: 265 SYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISA 324
S +H+ ++ G TI + + F + +L+D N + FF + WL RL+ IS
Sbjct: 1048 SPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISI 1107
Query: 325 GVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQY 384
++ + L M++L G + G+A+SY + L +++ + SVER+N Y
Sbjct: 1108 ALITTTGL-MIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHY 1166
Query: 385 MHIQS-EAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIV 443
+ S EA ++ P +WP G+V + ++RYR + PLVL ++ T + KIGIV
Sbjct: 1167 IKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIV 1226
Query: 444 GRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRY 503
GRTGSGKS+L ALFRLVE SGG I IDGV IS IGL DLRS+ IIPQ+P LF+GTVR
Sbjct: 1227 GRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRS 1286
Query: 504 NLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLR 563
NLDP +QY++ +IW+ L + ++E + + L S V+E+G N+S+G+RQL C+ RALLR
Sbjct: 1287 NLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLR 1346
Query: 564 RSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
+IL+LDEATA++D TD ++ +TIR FADCT++T+AHR+ TV+ ++ + G +
Sbjct: 1347 HCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQV 1405
Score = 81.3 bits (199), Expect = 8e-15
Identities = 57/195 (29%), Positives = 91/195 (46%), Gaps = 14/195 (7%)
Query: 427 LHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSR 486
LH I + G +GI G GSGK++LISA+ + G+I I G
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624
Query: 487 FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSN 546
F + Q + T+R N+ +Y ++ VL C LR + + + E G+N
Sbjct: 625 FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGAN 684
Query: 547 WSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFADCTVITVAHRI 605
S GQRQ L RAL I +LD+ +++D + ++I IR TV+ V H++
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQL 744
Query: 606 PTVMDCTMVLSINDG 620
++DC V+ + +G
Sbjct: 745 QYLVDCDEVIFMKEG 759
>MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (ABC
transporter MOAT-C) (SMRP)
Length = 1436
Score = 344 bits (883), Expect = 4e-94
Identities = 212/659 (32%), Positives = 343/659 (51%), Gaps = 47/659 (7%)
Query: 1 MSEGVIQQEGPYQQLLATSKEFQDL-------------VNAHKVTDGSNQLVNVTFSRAS 47
M EG I + G +++L+ + ++ + +N+ K GS + + S
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEATGSQKSQDKGPKPGS 815
Query: 48 IKITQTLVENKGKEANGNQLIKQEEREKGDKGLKPYLQYLNQMKGYIFFFVASLGHFIFL 107
+K + K ++ QL++ EE+ +G Y Y+ G + F V + + +
Sbjct: 816 VK------KEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNV 869
Query: 108 VCQILQNLWMAANV----------------------DNPRVSTFQLIFVYFLLGASSAFF 145
W++ + DNP + + I Y L A
Sbjct: 870 GSTAFSTWWLSYWIKQGSGNSTVYQGNRSFVSDSMKDNPFMQYYASI--YALSMAVMLIL 927
Query: 146 MLTRSLFVIALGLQSSKYLFLQLMNSLFRAPMPFYDCTPLGRILSRVSSELSIMDLDIPF 205
R + + L++S L +L + R+PM F+D TP GRIL+R S ++ +D+ +PF
Sbjct: 928 KAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPF 987
Query: 206 SLT-FAVGTTMNFYSTLTVFSVVTWQVLIVAIPMVYITIRLQRYYFASAKEVMRITGTTK 264
F + F+ + V W ++ V P++ + L +E+ R+ T+
Sbjct: 988 QAEMFIQNVILVFFCVGMIAGVFPWFLVAVG-PLLILFSLLHIVSRVLIRELKRLDNITQ 1046
Query: 265 SYVANHVAETVSGAVTIRTFEEEDRFFQKNLDLIDINASSFFHNFASNEWLIQRLETISA 324
S +H+ ++ G TI + + F + +L+D N + FF + WL RL+ IS
Sbjct: 1047 SPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLPVRLDIISI 1106
Query: 325 GVLASAALCMVILPPGTFTSGFIGMALSYGLALNSFLVNSIQSQCTLANQIISVERLNQY 384
++ S L M++ S + G+A+SY + L +++ + SVER+N Y
Sbjct: 1107 ALITSTGL-MIVSGMARSLSAYAGLAISYAVQLIGLFQFTVRLASETEARFTSVERINHY 1165
Query: 385 MHIQS-EAKEIVEGNRPPLNWPIAGKVEINDLKIRYRPDGPLVLHGITCTFEVGHKIGIV 443
+ S EA ++ PP +WP G+V + ++RYR + PLVL ++ T + KIGIV
Sbjct: 1166 IKTLSLEAPARIKNKAPPHDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIV 1225
Query: 444 GRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSRFGIIPQDPTLFTGTVRY 503
GRTGSGKS+L ALFRLVE SGG I IDG+ IS IGL DLRS+ IIPQ+P LF+GTVR
Sbjct: 1226 GRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRS 1285
Query: 504 NLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSNWSMGQRQLFCLGRALLR 563
NLDP +QY++ +IW+ L + ++E + + L S V+E+G N+S+G+RQL C+ RALLR
Sbjct: 1286 NLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLR 1345
Query: 564 RSRILVLDEATASVDNSTDYILLKTIRTEFADCTVITVAHRIPTVMDCTMVLSINDGNL 622
+IL+LDEATA++D TD ++ +TIR FADCT++T+AHR+ TV+ ++ + G +
Sbjct: 1346 HCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQV 1404
Score = 77.8 bits (190), Expect = 8e-14
Identities = 54/195 (27%), Positives = 91/195 (45%), Gaps = 14/195 (7%)
Query: 427 LHGITCTFEVGHKIGIVGRTGSGKSTLISALFRLVEPSGGNIIIDGVDISSIGLHDLRSR 486
L+ I E G +GI G GSGK++L+SA+ + G+I + G
Sbjct: 578 LYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGT------------- 624
Query: 487 FGIIPQDPTLFTGTVRYNLDPLSQYSDQEIWEVLGKCQLREVVQEKDEGLNSSVVEDGSN 546
F + Q + T+R N+ ++ ++ VL C LR + + + E G+N
Sbjct: 625 FAYVAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGAN 684
Query: 547 WSMGQRQLFCLGRALLRRSRILVLDEATASVD-NSTDYILLKTIRTEFADCTVITVAHRI 605
S GQRQ L RAL I +LD+ +++D + ++I IR TV+ V H++
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQL 744
Query: 606 PTVMDCTMVLSINDG 620
++DC V+ + +G
Sbjct: 745 QYLVDCDEVIFMKEG 759
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.323 0.138 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,553,870
Number of Sequences: 164201
Number of extensions: 2960043
Number of successful extensions: 11372
Number of sequences better than 10.0: 885
Number of HSP's better than 10.0 without gapping: 694
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 9512
Number of HSP's gapped (non-prelim): 1187
length of query: 663
length of database: 59,974,054
effective HSP length: 117
effective length of query: 546
effective length of database: 40,762,537
effective search space: 22256345202
effective search space used: 22256345202
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Medicago: description of AC147714.15