BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC147517.6 + phase: 0 /pseudo
         (1055 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

SNQ2_YEAST (P32568) SNQ2 protein                                      168  8e-41
PDRC_YEAST (Q02785) ATP-dependent permease PDR12                      163  3e-39
BFR1_SCHPO (P41820) Brefeldin A resistance protein                    162  4e-39
YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W        160  2e-38
CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3              160  2e-38
CDR2_CANAL (P78595) Multidrug resistance protein CDR2                 157  2e-37
CDR4_CANAL (O74676) ABC transporter CDR4                              154  1e-36
PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin             154  2e-36
CDR1_CANAL (P43071) Multidrug resistance protein CDR1                 154  2e-36
CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1 (Pleom...   151  8e-36
PDRA_YEAST (P51533) ATP-dependent permease PDR10                      150  2e-35
PDRF_YEAST (Q04182) ATP-dependent permease PDR15                      149  4e-35
WHIT_DROME (P10090) White protein                                     117  2e-25
WHIT_CERCA (Q17320) White protein                                     117  2e-25
WHIT_LUCCU (Q05360) White protein                                     115  6e-25
ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4      114  1e-24
WHIT_ANOGA (Q27256) White protein                                     107  2e-22
AUS1_YEAST (Q08409) ATP-dependent permease AUS1                       105  6e-22
PDRB_YEAST (P40550) ATP-dependent permease PDR11                      103  2e-21
ABG8_HUMAN (Q9H221) ATP-binding cassette, sub-family G, member 8...   102  5e-21

>SNQ2_YEAST (P32568) SNQ2 protein
          Length = 1501

 Score =  168 bits (425), Expect = 8e-41
 Identities = 101/303 (33%), Positives = 172/303 (56%), Gaps = 11/303 (3%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARA 696
            +K++ ++ ++    ALVG  G CGL++EQRK+L++ VELVA P ++ F+DEPTSGLD+++
Sbjct: 970  EKIIRVLGMEEYAEALVGEVG-CGLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQS 1028

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            +  +++ +R     G++++CTIHQPS  +FE FD LLLL++GGQ +Y G +G NS+ ++N
Sbjct: 1029 SWAIIQLLRKLSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILN 1088

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKA----LVKE 812
            +FE   G RK     NPA ++LE   +     +  D+ E + NS  +   K     L+ +
Sbjct: 1089 YFER-NGARKCDSSENPAEYILEAIGAGATASVKEDWHEKWLNSVEFEQTKEKVQDLIND 1147

Query: 813  LSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSM 872
            LS     S+    PS+Y+ S+  Q    L +   S+WR+  Y   + +      + +G  
Sbjct: 1148 LSKQETKSEVGDKPSKYATSYAYQFRYVLIRTSTSFWRSLNYIMSKMMLMLVGGLYIGFT 1207

Query: 873  FWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYFS 932
            F+++G   +    L NAM + + ++IL      N +Q      R +F    +  N+F++S
Sbjct: 1208 FFNVG---KSYVGLQNAMFAAFISIIL-SAPAMNQIQGRAIASRELFEVRESQSNMFHWS 1263

Query: 933  ICL 935
            + L
Sbjct: 1264 LVL 1266



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 42/138 (30%), Positives = 68/138 (48%)

Query: 16  DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTT 75
           D    + GL    +T VGN  +R +SGG++KR++  E L         D  + GLD+ST 
Sbjct: 285 DLYATIFGLRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTA 344

Query: 76  FQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESI 135
            +   ++R   ++LK T  +++ Q     Y  FD + +L     IY G       +F  +
Sbjct: 345 LEYAKAIRIMTNLLKSTAFVTIYQASENIYETFDKVTVLYSGKQIYFGLIHEAKPYFAKM 404

Query: 136 GFKCPNRKGVADFLQEVT 153
           G+ CP R+  A+FL  +T
Sbjct: 405 GYLCPPRQATAEFLTALT 422



 Score = 69.7 bits (169), Expect = 4e-11
 Identities = 73/289 (25%), Positives = 124/289 (42%), Gaps = 35/289 (12%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L+   N  VG   V G+S  +RKR+++A  L A  SI   D  T GLDA  A    + +R
Sbjct: 293 LRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTALEYAKAIR 352

Query: 706 NTVDTGR-TVVCTIHQPSIDIFESFDELLLLKQGGQEIYVG----------------PLG 748
              +  + T   TI+Q S +I+E+FD++ +L   G++IY G                P  
Sbjct: 353 IMTNLLKSTAFVTIYQASENIYETFDKVTVL-YSGKQIYFGLIHEAKPYFAKMGYLCPPR 411

Query: 749 HNSSNLINHFEGIQGVRKIKDGYNPATWMLEVTTSSKEREL----GIDFAELYKNSELY- 803
             ++  +       G   IK GY       +V  +++E E       +FA++ K+   Y 
Sbjct: 412 QATAEFLTALTDPNGFHLIKPGYEN-----KVPRTAEEFETYWLNSPEFAQMKKDIAAYK 466

Query: 804 -RINKALVKEL---SAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRF 859
            ++N    KE+   S     SK     S Y+ S++ Q   C  +     + N  Y  I  
Sbjct: 467 EKVNTEKTKEVYDESMAQEKSKYTRKKSYYTVSYWEQVKLCTQRGFQRIYGNKSYTVINV 526

Query: 860 LYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSV 908
             +   + + GS+F++  S        F+  G +Y A++   +M   ++
Sbjct: 527 CSAIIQSFITGSLFYNTPS---STSGAFSRGGVLYFALLYYSLMGLANI 572



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 40/141 (28%), Positives = 78/141 (54%), Gaps = 9/141 (6%)

Query: 18   VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTF 76
            ++RVLG+E  A+ +VG      ++  Q+K+L+ G E++  P   LF+DE ++GLDS +++
Sbjct: 972  IIRVLGMEEYAEALVGEVGC-GLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSW 1030

Query: 77   QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGP----REHVLEF 131
             I+  +R+ +     +++ ++ QP    +  FD ++LL      +Y G        +L +
Sbjct: 1031 AIIQLLRK-LSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNY 1089

Query: 132  FESIGF-KCPNRKGVADFLQE 151
            FE  G  KC + +  A+++ E
Sbjct: 1090 FERNGARKCDSSENPAEYILE 1110


>PDRC_YEAST (Q02785) ATP-dependent permease PDR12
          Length = 1511

 Score =  163 bits (412), Expect = 3e-39
 Identities = 103/326 (31%), Positives = 176/326 (53%), Gaps = 16/326 (4%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARA 696
            +K++ L+ ++    ALVG  G  GL++EQRK+L++ VELVA PS++ F+DEPTSGLD+++
Sbjct: 960  EKIITLLGMQNYAEALVGKTGR-GLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQS 1018

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A  +++ +R   D+G++++CTIHQPS  +FE FD LLLLK+GG+ +Y G +G NS  L+ 
Sbjct: 1019 AWSIVQFMRALADSGQSILCTIHQPSATLFEQFDRLLLLKKGGKMVYFGDIGPNSETLLK 1078

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKALVKELSAP 816
            +FE   G+ K     NPA ++L    +     +  D+ +L+  S      +A V+EL   
Sbjct: 1079 YFERQSGM-KCGVSENPAEYILNCIGAGATASVNSDWHDLWLASPECAAARAEVEELHRT 1137

Query: 817  AP---CSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMF 873
             P    + D    ++++ S+ TQ    L +    +WR+P Y   +F    A A+ +G  +
Sbjct: 1138 LPGRAVNDDPELATRFAASYMTQIKCVLRRTALQFWRSPVYIRAKFFECVACALFVGLSY 1197

Query: 874  WDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYFSI 933
              +   +    + F+++      ++LI +   N +       R ++    AA N F++S+
Sbjct: 1198 VGVNHSVGGAIEAFSSI----FMLLLIALAMINQLHVFAYDSRELYEVREAASNTFHWSV 1253

Query: 934  CLW----AGKYPSPIC--FCTSCGLW 953
             L        + S +C   C  C  W
Sbjct: 1254 LLLCHAAVENFWSTLCQFMCFICYYW 1279



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 45/148 (30%), Positives = 74/148 (49%)

Query: 6   TEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDE 65
           T  Q  + I D    V GL     T VGN  +R +SGG++KR++  E           D 
Sbjct: 262 TRKQYVDNIRDMWCTVFGLRHTYATKVGNDFVRGVSGGERKRVSLVEAQAMNASIYSWDN 321

Query: 66  ISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPR 125
            + GLD+ST  +   ++R   +++  + ++++ Q     Y LFD   +L +   IY GP 
Sbjct: 322 ATRGLDASTALEFAQAIRTATNMVNNSAIVAIYQAGENIYELFDKTTVLYNGRQIYFGPA 381

Query: 126 EHVLEFFESIGFKCPNRKGVADFLQEVT 153
           +  + +F+ +G+  PNR   A+FL  VT
Sbjct: 382 DKAVGYFQRMGWVKPNRMTSAEFLTSVT 409



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 71/302 (23%), Positives = 126/302 (41%), Gaps = 47/302 (15%)

Query: 654 VGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAA---AVVMRTVRNTVDT 710
           VG   V G+S  +RKR+++      N SI   D  T GLDA  A   A  +RT  N V+ 
Sbjct: 288 VGNDFVRGVSGGERKRVSLVEAQAMNASIYSWDNATRGLDASTALEFAQAIRTATNMVN- 346

Query: 711 GRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGVRKIKDG 770
             + +  I+Q   +I+E FD+  +L   G++IY GP    +   + +F+ +  V+   + 
Sbjct: 347 -NSAIVAIYQAGENIYELFDKTTVL-YNGRQIYFGP----ADKAVGYFQRMGWVK--PNR 398

Query: 771 YNPATWMLEVTTSSKERELGI-------------DFAELYKNSELYR------------- 804
              A ++  VT   + R L I             +F E + NSE Y+             
Sbjct: 399 MTSAEFLTSVTVDFENRTLDIKPGYEDKVPKSSSEFEEYWLNSEDYQELLRTYDDYQSRH 458

Query: 805 -INKALVK-ELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYS 862
            +N+   + +++      +     SQY  +++TQ   C+ +       +  Y  +     
Sbjct: 459 PVNETRDRLDVAKKQRLQQGQRENSQYVVNYWTQVYYCMIRGFQRVKGDSTYTKVYLSSF 518

Query: 863 TAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVILIG-------VMNCNSVQPVVAVE 915
              A+++GSMF  +  K +       + G M   V+L         + N  S +PV+   
Sbjct: 519 LIKALIIGSMFHKIDDKSQSTTAGAYSRGGMLFYVLLFASVTSLAEIGNSFSSRPVIVKH 578

Query: 916 RT 917
           ++
Sbjct: 579 KS 580



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 40/139 (28%), Positives = 78/139 (55%), Gaps = 9/139 (6%)

Query: 18   VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTF 76
            ++ +LG++  A+ +VG    R ++  Q+K+L+ G E++  P+  LF+DE ++GLDS + +
Sbjct: 962  IITLLGMQNYAEALVGKTG-RGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQSAW 1020

Query: 77   QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGP----REHVLEF 131
             IV  MR      + +++ ++ QP    +  FD ++LL     ++Y G      E +L++
Sbjct: 1021 SIVQFMRALADSGQ-SILCTIHQPSATLFEQFDRLLLLKKGGKMVYFGDIGPNSETLLKY 1079

Query: 132  FE-SIGFKCPNRKGVADFL 149
            FE   G KC   +  A+++
Sbjct: 1080 FERQSGMKCGVSENPAEYI 1098


>BFR1_SCHPO (P41820) Brefeldin A resistance protein
          Length = 1530

 Score =  162 bits (410), Expect = 4e-39
 Identities = 98/298 (32%), Positives = 165/298 (54%), Gaps = 12/298 (4%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARA 696
            + V++L+E++    A++G PG  GL++EQRKR T+ VEL A P+++ F+DEPTSGLD+++
Sbjct: 1000 ESVIKLLEMESYAEAIIGTPG-SGLNVEQRKRATIGVELAAKPALLLFLDEPTSGLDSQS 1058

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A  ++  +R   D G+ ++CTIHQPS  +F+ FD LLLL++GG+ +Y G +G +S  L+N
Sbjct: 1059 AWSIVCFLRKLADAGQAILCTIHQPSAVLFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLN 1118

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKALVKELSAP 816
            +FE    V    DG NPA ++L+V  +        D+ E++ NSE  +   A + +++A 
Sbjct: 1119 YFESHGAVHCPDDG-NPAEYILDVIGAGATATTNRDWHEVWNNSEERKAISAELDKINAS 1177

Query: 817  APCSKDLYFPSQYSRSFFT-----QCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGS 871
               S+D    S+  RS +      Q    + +   SYWR P     +        + +G 
Sbjct: 1178 FSNSEDKKTLSKEDRSTYAMPLWFQVKMVMTRNFQSYWREPSILMSKLALDIFAGLFIGF 1237

Query: 872  MFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVF 929
             F++ G  +   Q++ N + +++ A +L  V   N +QP     R VF       N++
Sbjct: 1238 TFYNQGLGV---QNIQNKLFAVFMATVL-AVPLINGLQPKFIELRNVFEVREKPSNIY 1291



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 48/139 (34%), Positives = 70/139 (49%)

Query: 18  VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQ 77
           +    GL    +T VGN  +R +SGG++KR+T  E           D  + GLDSST F+
Sbjct: 287 IATAFGLTHTFNTKVGNDFVRGVSGGERKRVTISEGFATRPTIACWDNSTRGLDSSTAFE 346

Query: 78  IVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGF 137
            VN +R   + LK T  ++  Q   + Y LFD I +L     IY GP +   ++F  +GF
Sbjct: 347 FVNVLRTCANELKMTSFVTAYQASEKIYKLFDRICVLYAGRQIYYGPADKAKQYFLDMGF 406

Query: 138 KCPNRKGVADFLQEVTSRK 156
            C  R+   DFL  ++  K
Sbjct: 407 DCHPRETTPDFLTAISDPK 425



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 74/317 (23%), Positives = 126/317 (39%), Gaps = 60/317 (18%)

Query: 651 NALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAA---AVVMRTVRNT 707
           N  VG   V G+S  +RKR+T++      P+I   D  T GLD+  A     V+RT  N 
Sbjct: 298 NTKVGNDFVRGVSGGERKRVTISEGFATRPTIACWDNSTRGLDSSTAFEFVNVLRTCAN- 356

Query: 708 VDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGVRKI 767
            +   T   T +Q S  I++ FD + +L   G++IY GP        ++           
Sbjct: 357 -ELKMTSFVTAYQASEKIYKLFDRICVL-YAGRQIYYGPADKAKQYFLDMGFDCHPRETT 414

Query: 768 KDGY----NPATWMLEVTTSSKERELGIDFAELYKNSELYR------------------- 804
            D      +P          ++      +F ++++NS +Y                    
Sbjct: 415 PDFLTAISDPKARFPRKGFENRVPRTPDEFEQMWRNSSVYADLMAEMESYDKRWTETTPA 474

Query: 805 -------------INKALVKEL---SAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSY 848
                        I+     EL   SA A  SK +   S Y+ +F  Q   CL +    Y
Sbjct: 475 SSEAPEKDNFGSDISATTKHELYRQSAVAEKSKRVKDTSPYTVTFSQQLWYCLARSWERY 534

Query: 849 WRNPEY---NAIRFLYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVI------L 899
             +P Y    A  FL+    ++++GS+F+D+        D+F+  G ++ +++      L
Sbjct: 535 INDPAYIGSMAFAFLFQ---SLIIGSIFYDMKL---NTVDVFSRGGVLFFSILFCALQSL 588

Query: 900 IGVMNCNSVQPVVAVER 916
             + N  S +P++A  R
Sbjct: 589 SEIANMFSQRPIIAKHR 605



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 42/142 (29%), Positives = 77/142 (53%), Gaps = 9/142 (6%)

Query: 18   VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTF 76
            V+++L +E  A+ ++G      ++  Q+KR T G E+   P   LF+DE ++GLDS + +
Sbjct: 1002 VIKLLEMESYAEAIIGTPG-SGLNVEQRKRATIGVELAAKPALLLFLDEPTSGLDSQSAW 1060

Query: 77   QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGP-REH---VLEF 131
             IV  +R+     +  ++ ++ QP    ++ FD ++LL      +Y G   EH   +L +
Sbjct: 1061 SIVCFLRKLADAGQ-AILCTIHQPSAVLFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNY 1119

Query: 132  FESIG-FKCPNRKGVADFLQEV 152
            FES G   CP+    A+++ +V
Sbjct: 1120 FESHGAVHCPDDGNPAEYILDV 1141


>YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W
          Length = 1333

 Score =  160 bits (405), Expect = 2e-38
 Identities = 102/320 (31%), Positives = 177/320 (54%), Gaps = 17/320 (5%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARA 696
            +K++ ++E++    ALVG  G  GL++EQRK+L++ VELV  P ++ F+DEPTSGLD+++
Sbjct: 846  EKIISILEMQEFSEALVGEIGY-GLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQS 904

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A  V++ ++     G++++CTIHQPS  +FE FD LLLL +GGQ IY G +G NSS++I 
Sbjct: 905  AWAVVKMLKRLALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIK 964

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELY-RINKA---LVKE 812
            +FE   G RK +   NPA ++LE   +     +  ++ ++++ S  Y  IN+    ++K+
Sbjct: 965  YFEK-NGARKCQQNENPAEYILEAIGAGATASVQQNWPDIWQKSHEYANINEKINDMIKD 1023

Query: 813  LSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSM 872
            LS+     K     S+Y+ S+  Q    L +   ++WRN  Y   + +      + +G  
Sbjct: 1024 LSS-TTLHKTATRASKYATSYSYQFHHVLKRSSLTFWRNLNYIMAKMMLLMISGLFIGFT 1082

Query: 873  FWDLG-SKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYF 931
            F+ +G + I  +  LF          I+I     N +Q    V + ++    +  N+F++
Sbjct: 1083 FFHVGVNAIGLQNSLFACF-----MAIVISAPATNQIQERATVAKELYEVRESKSNMFHW 1137

Query: 932  SICL---WAGKYPSPICFCT 948
            S+ L   +  + P  + F T
Sbjct: 1138 SLLLITHYLNELPYHLLFST 1157



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 45/147 (30%), Positives = 76/147 (51%), Gaps = 3/147 (2%)

Query: 10  KENLIT---DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEI 66
           KE  IT   ++  ++ GL    DT VGN  I  +SGG++KR++  E L         D  
Sbjct: 147 KEEYITANREFYAKIFGLTHTFDTKVGNDFISGVSGGERKRVSIAEALAAKGSIYCWDNA 206

Query: 67  STGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPRE 126
           + GLDSST  +   ++R   ++L  T ++++ Q     Y  FD + +L     I+ G   
Sbjct: 207 TRGLDSSTALEFARAIRTMTNLLGTTALVTVYQASENIYETFDKVTVLYAGRQIFCGKTT 266

Query: 127 HVLEFFESIGFKCPNRKGVADFLQEVT 153
              ++FE++G+ CP R+  A++L  +T
Sbjct: 267 EAKDYFENMGYLCPPRQSTAEYLTAIT 293



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 65/280 (23%), Positives = 119/280 (42%), Gaps = 33/280 (11%)

Query: 654 VGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVRNTVD-TGR 712
           VG   + G+S  +RKR+++A  L A  SI   D  T GLD+  A    R +R   +  G 
Sbjct: 172 VGNDFISGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDSSTALEFARAIRTMTNLLGT 231

Query: 713 TVVCTIHQPSIDIFESFDELLLLKQGGQEI---------------YVGPLGHNSSNLINH 757
           T + T++Q S +I+E+FD++ +L  G Q                 Y+ P   +++  +  
Sbjct: 232 TALVTVYQASENIYETFDKVTVLYAGRQIFCGKTTEAKDYFENMGYLCPPRQSTAEYLTA 291

Query: 758 FEGIQGVRKIKDGYNPATWMLEVTTSSKEREL----GIDFAELYKNSELYR--INKALVK 811
                G+ +IK G+       +V  ++ E E       ++A L    + Y+  +N    K
Sbjct: 292 ITDPNGLHEIKPGFE-----YQVPHTADEFEKYWLDSPEYARLKGEIQKYKHEVNTEWTK 346

Query: 812 EL---SAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVL 868
           +    S     SK     S Y+ S++ Q   C  +     + +  Y  I    + A A +
Sbjct: 347 KTYNESMAQEKSKGTRKKSYYTVSYWEQIRLCTIRGFLRIYGDKSYTVINTCAAIAQAFI 406

Query: 869 LGSMFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSV 908
            GS+F+   S        F+  G ++ +++   +M   ++
Sbjct: 407 TGSLFYQAPS---STLGAFSRSGVLFFSLLYYSLMGLANI 443



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 37/141 (26%), Positives = 76/141 (53%), Gaps = 9/141 (6%)

Query: 18  VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVG-PTKALFMDEISTGLDSSTTF 76
           ++ +L ++  ++ +VG      ++  Q+K+L+ G  LVG P   LF+DE ++GLDS + +
Sbjct: 848 IISILEMQEFSEALVGEIGY-GLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQSAW 906

Query: 77  QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGP----REHVLEF 131
            +V  +++ + +   +++ ++ QP    +  FD ++LL      IY G        V+++
Sbjct: 907 AVVKMLKR-LALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIKY 965

Query: 132 FESIGF-KCPNRKGVADFLQE 151
           FE  G  KC   +  A+++ E
Sbjct: 966 FEKNGARKCQQNENPAEYILE 986


>CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3
          Length = 1501

 Score =  160 bits (404), Expect = 2e-38
 Identities = 99/296 (33%), Positives = 162/296 (54%), Gaps = 11/296 (3%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSI-IFMDEPTSGLDARA 696
            +K+++L+E++   +A+VG+PG  GL++EQRKRLT+AVELVA P + +F+DEPTSGLD++ 
Sbjct: 959  EKIIDLLEMRTYVDAIVGVPGE-GLNVEQRKRLTIAVELVARPKLLVFLDEPTSGLDSQT 1017

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A  + + +R   + G+ ++CTIHQPS  + E FD LLLL Q G+ +Y G  G N   LI 
Sbjct: 1018 AWSICKLIRKLANHGQAILCTIHQPSAILLEEFDRLLLL-QKGETVYFGEFGANCHTLIE 1076

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYR-INKAL--VKEL 813
            +FE   G  K     NPA WML V  ++   +   D+ E ++NS  YR +   L  ++E+
Sbjct: 1077 YFER-NGASKCPQHANPAEWMLGVIGAAPGTQANQDYFETWRNSPEYRAVQNELHRLEEM 1135

Query: 814  SAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMF 873
               A   K+      Y+ SF+ Q +  + +    YWR P Y   +F  +   ++  G  +
Sbjct: 1136 PGLASGEKEPDTNQAYAASFWKQYIFVVHRLFQQYWRTPSYIYSKFAMAVLCSLFNGFTY 1195

Query: 874  WDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVF 929
            +   + +   Q L N M S++S  +++  +      P+   +R ++         F
Sbjct: 1196 YKSQNSM---QGLKNQMLSIFSMFVVLTTL-AQQYVPLFVTQRDLYEARERPSKTF 1247



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 46/141 (32%), Positives = 79/141 (55%)

Query: 14  ITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSS 73
           + D V+   GL    +T VGN  IR ISGG++KRL+  E+ +        D  + GLD++
Sbjct: 268 VVDVVMATYGLSHTKNTKVGNDFIRGISGGERKRLSIAEVTLVQASIQCWDNSTRGLDAA 327

Query: 74  TTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFE 133
           T  + ++S++    IL  T +I++ Q     Y+LFD +I++ + + I+ G  +    +F+
Sbjct: 328 TALEFISSLKTSASILNDTPLIAIYQCSQNAYDLFDKVIVMYEGYQIFFGSSQRAAAYFK 387

Query: 134 SIGFKCPNRKGVADFLQEVTS 154
            +GF C +R+   DFL  +TS
Sbjct: 388 KMGFVCQDRQTTPDFLTSITS 408



 Score = 48.9 bits (115), Expect = 7e-05
 Identities = 37/138 (26%), Positives = 69/138 (49%), Gaps = 8/138 (5%)

Query: 18   VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTF 76
            ++ +L +    D +VG      ++  Q+KRLT   E++  P   +F+DE ++GLDS T +
Sbjct: 961  IIDLLEMRTYVDAIVG-VPGEGLNVEQRKRLTIAVELVARPKLLVFLDEPTSGLDSQTAW 1019

Query: 77   QIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGP----REHVLEFF 132
             I   +R+  +  +  ++ ++ QP       FD ++LL     +Y G        ++E+F
Sbjct: 1020 SICKLIRKLANHGQ-AILCTIHQPSAILLEEFDRLLLLQKGETVYFGEFGANCHTLIEYF 1078

Query: 133  ESIG-FKCPNRKGVADFL 149
            E  G  KCP     A+++
Sbjct: 1079 ERNGASKCPQHANPAEWM 1096



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 63/264 (23%), Positives = 114/264 (42%), Gaps = 35/264 (13%)

Query: 640 VMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAV 699
           VM    L   +N  VG   + G+S  +RKRL++A   +   SI   D  T GLDA  A  
Sbjct: 272 VMATYGLSHTKNTKVGNDFIRGISGGERKRLSIAEVTLVQASIQCWDNSTRGLDAATALE 331

Query: 700 VMRTVRNTVD-TGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHF 758
            + +++ +      T +  I+Q S + ++ FD+++++ +G Q I+ G    +S     +F
Sbjct: 332 FISSLKTSASILNDTPLIAIYQCSQNAYDLFDKVIVMYEGYQ-IFFG----SSQRAAAYF 386

Query: 759 EGIQGV-------------------RKIKDGY------NPATWMLEVTTSSKERELGIDF 793
           + +  V                   R IK GY       P  +      S + + L  + 
Sbjct: 387 KKMGFVCQDRQTTPDFLTSITSPAERIIKPGYERLVPRTPKEFYRYWRRSPERQALLEEI 446

Query: 794 AELYKNSELYRINKALVKELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPE 853
            E   N E Y   + + +  +A    +K  Y  S Y+ S   Q +  + K++W   R   
Sbjct: 447 DEYLDNCENYDQKQKIFEANNAKK--AKHTYNKSSYTVSLPMQ-VRYIMKRYWDRMRGDI 503

Query: 854 YNAIRFLY-STAVAVLLGSMFWDL 876
              +  +  + A+A++L S+F++L
Sbjct: 504 IVPLSTVAGNIAMALILSSVFYNL 527


>CDR2_CANAL (P78595) Multidrug resistance protein CDR2
          Length = 1499

 Score =  157 bits (396), Expect = 2e-37
 Identities = 108/330 (32%), Positives = 166/330 (49%), Gaps = 22/330 (6%)

Query: 640  VMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARAAA 698
            V++L+E+    +ALVG+ G  GL++EQRKRLT+ VELVA P ++ F+DEPTSGLD++ A 
Sbjct: 978  VIDLLEMTDYADALVGVAGE-GLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAW 1036

Query: 699  VVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHF 758
             + + +R   D G+ ++CTIHQPS  I   FD+LL L++GG+  Y G LG N   +IN+F
Sbjct: 1037 SICKLMRKLADHGQAILCTIHQPSALIMAEFDKLLFLQKGGRTAYFGELGENCQTMINYF 1096

Query: 759  EGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKALVKELSA--- 815
            E   G        NPA WML+V  ++       D+ E+++NS  Y+  +  +  + A   
Sbjct: 1097 EK-YGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAELS 1155

Query: 816  PAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMFWD 875
              P   D     +Y+   + Q +   W+     WR+P Y     +YS  + V+  S+F  
Sbjct: 1156 KLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGY-----IYSKLILVISSSLF-- 1208

Query: 876  LGSKIEKEQDLFNAMGSMYSAVILIGV---MNCNSVQPVVAVERTVFYRESAAGNVFYFS 932
            +G    K ++    + S   AV +  V      + + P     R V+    A    F + 
Sbjct: 1209 IGFSFFKSKNNLQGLQSQMLAVFMFFVPFTTFIDQMLPYFVKHRAVYEVREAPSRTFSW- 1267

Query: 933  ICLWAGKYPSPICFCTSCG-----LWHYSV 957
                AG+  S I F    G      W+Y V
Sbjct: 1268 FAFIAGQITSEIPFQIVVGTISYFCWYYPV 1297



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 46/145 (31%), Positives = 84/145 (57%)

Query: 23  GLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQIVNSM 82
           GL    +T VGN  +R +SGG++KR++  E  +        D  + GLDS+T  + + ++
Sbjct: 284 GLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRAL 343

Query: 83  RQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGFKCPNR 142
           +    IL  T +I++ Q   + Y LFD++++L + + I+ G      E+FE++G+KCP R
Sbjct: 344 KTSATILDTTPLIAIYQCSQDAYELFDNVVVLYEGYQIFFGKASKAKEYFENMGWKCPQR 403

Query: 143 KGVADFLQEVTSRKDQEQYCEHKDR 167
           +  ADFL  +T+  ++E    ++D+
Sbjct: 404 QTTADFLTSLTNPAEREPLPGYEDK 428



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 77/315 (24%), Positives = 131/315 (41%), Gaps = 49/315 (15%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L   RN  VG   V G+S  +RKR+++A   ++  +I   D  T GLD+  A   +R ++
Sbjct: 285 LSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALK 344

Query: 706 NT---VDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQ 762
            +   +DT  T +  I+Q S D +E FD +++L +G Q I+ G     +S    +FE + 
Sbjct: 345 TSATILDT--TPLIAIYQCSQDAYELFDNVVVLYEGYQ-IFFG----KASKAKEYFENMG 397

Query: 763 GVRKIKDGYNPATWMLEVTTSSKEREL----------GIDFAELYKNSELY--------- 803
              K       A ++  +T  ++   L            +F   +KNS  Y         
Sbjct: 398 W--KCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETFWKNSPEYAELTKEIDE 455

Query: 804 ------RINKALVKELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAI 857
                 R N       S     S +    S Y+ SFF Q    + +       +P    I
Sbjct: 456 YFVECERSNTGETYRESHVGKQSNNTRPSSPYTVSFFMQVRYVIARNFLRMKGDPSIPLI 515

Query: 858 RFLYSTAVAVLLGSMFWDLGSKIEKEQDLFNAM-GSMYSAVI------LIGVMNCNSVQP 910
             L    + ++L S+F++L     K  D F    G+++ +V+      L+ +++    +P
Sbjct: 516 SILSQLVMGLILASVFFNL----RKSTDTFYFRGGALFFSVLFNAFSSLLEILSLYEARP 571

Query: 911 VVAVERT-VFYRESA 924
           +V   R    YR SA
Sbjct: 572 IVEKHRKYALYRPSA 586



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 43/144 (29%), Positives = 72/144 (49%), Gaps = 9/144 (6%)

Query: 16   DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSST 74
            DYV+ +L +   AD +VG A    ++  Q+KRLT G E++  P   LF+DE ++GLDS T
Sbjct: 976  DYVIDLLEMTDYADALVGVAG-EGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQT 1034

Query: 75   TFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGPR----EHVL 129
             + I   MR+     +  ++ ++ QP       FD ++ L       Y G      + ++
Sbjct: 1035 AWSICKLMRKLADHGQ-AILCTIHQPSALIMAEFDKLLFLQKGGRTAYFGELGENCQTMI 1093

Query: 130  EFFESIGF-KCPNRKGVADFLQEV 152
             +FE  G   CP     A+++ +V
Sbjct: 1094 NYFEKYGADPCPKEANPAEWMLQV 1117


>CDR4_CANAL (O74676) ABC transporter CDR4
          Length = 1490

 Score =  154 bits (389), Expect = 1e-36
 Identities = 103/327 (31%), Positives = 167/327 (50%), Gaps = 16/327 (4%)

Query: 640  VMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSI-IFMDEPTSGLDARAAA 698
            ++ L+E++   +A+VG+ G  GL++EQRKRL++ VELVA P + +F+DEPTSGLD++ A 
Sbjct: 967  IIRLLEMEQYADAVVGVSGE-GLNVEQRKRLSIGVELVAKPKLLVFLDEPTSGLDSQTAW 1025

Query: 699  VVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHF 758
             + + +R   D G+ ++CTIHQPS  +   FD LL L++GGQ +Y G LG N + LIN+F
Sbjct: 1026 SICKLIRKLADNGQAILCTIHQPSAILLAEFDRLLFLQRGGQTVYFGDLGKNFTTLINYF 1085

Query: 759  EGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELY-KNSELYRINKA--LVKELSA 815
            E   G  K     NPA WMLEV  ++   +   D+ +++ K+SE   +N    L+ E   
Sbjct: 1086 EK-YGAPKCPPEANPAEWMLEVIGAAPGSKANQDYYDVWLKSSEFQEMNSELDLMSEELV 1144

Query: 816  PAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMFWD 875
              P   D      Y+  ++ Q +    +     WR P Y   +FL     ++  G  F+ 
Sbjct: 1145 KKPLDDDPDRLKPYAAPYWEQYLFVTKRVFEQNWRTPSYLYSKFLLVVTSSLFNGFSFYK 1204

Query: 876  LGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYFSICL 935
                +   Q L N M S++  ++++  +      P    +R ++         F + I  
Sbjct: 1205 ADRSL---QGLQNQMFSVFMFLVILHTL-IQQYLPTFVSQRDLYEVRERPSKTFSW-ITF 1259

Query: 936  WAGKYPSPICFCTSCG-----LWHYSV 957
             A +  + I +   CG      W+Y V
Sbjct: 1260 IAAQVTAEIPWNIICGTLGYFCWYYPV 1286



 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 43/137 (31%), Positives = 79/137 (57%)

Query: 18  VLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQ 77
           V+ V GL    +T VGN  IR +SGG++KR++  E+ +        D  + GLDS+T  +
Sbjct: 284 VMAVYGLSHTRNTKVGNDFIRGVSGGERKRVSIAEITLNNAMVQCWDNSTRGLDSATALE 343

Query: 78  IVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGF 137
            + +++    I+  T ++++ Q   + Y+LFD ++L+   + IY G  +   ++F  +G+
Sbjct: 344 FIRALKASADIVHTTPLVAIYQCSQDAYDLFDKVVLMYQGYQIYFGSAKKAKQYFIDMGY 403

Query: 138 KCPNRKGVADFLQEVTS 154
           +CP R+  ADFL  +T+
Sbjct: 404 ECPQRQTTADFLTSLTN 420



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 68/260 (26%), Positives = 112/260 (42%), Gaps = 27/260 (10%)

Query: 640 VMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAV 699
           VM +  L   RN  VG   + G+S  +RKR+++A   + N  +   D  T GLD+  A  
Sbjct: 284 VMAVYGLSHTRNTKVGNDFIRGVSGGERKRVSIAEITLNNAMVQCWDNSTRGLDSATALE 343

Query: 700 VMRTVRNTVDTGRTV-VCTIHQPSIDIFESFDELLLLKQGGQEIYVG----------PLG 748
            +R ++ + D   T  +  I+Q S D ++ FD+++L+ QG Q IY G           +G
Sbjct: 344 FIRALKASADIVHTTPLVAIYQCSQDAYDLFDKVVLMYQGYQ-IYFGSAKKAKQYFIDMG 402

Query: 749 HNS----------SNLINHFEGIQGVRKIKDGYNPAT--WMLEVTTSSKERELGIDFAEL 796
           +            ++L N  E I  VR+  +G  P T     E    S E +  +   + 
Sbjct: 403 YECPQRQTTADFLTSLTNPAERI--VRQGFEGKVPQTPQEFYEYWKKSPEGQQIVADVDQ 460

Query: 797 YKNSELYRINKALVKELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNA 856
           Y         K  +KE +  A  S  L   S Y+ SFF Q      +       NP  + 
Sbjct: 461 YLTEHSSAAEKEAIKE-AHQARQSDHLKPASPYTVSFFMQVRYIAHRNILRIKGNPSIHL 519

Query: 857 IRFLYSTAVAVLLGSMFWDL 876
            +   +  ++ +L S+F++L
Sbjct: 520 FQIFGNIGMSFILSSIFYNL 539



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 49/165 (29%), Positives = 84/165 (50%), Gaps = 14/165 (8%)

Query: 9    QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKAL-FMDEIS 67
            +++N   DY++R+L +E  AD VVG +    ++  Q+KRL+ G  LV   K L F+DE +
Sbjct: 958  KEKNEYVDYIIRLLEMEQYADAVVGVSG-EGLNVEQRKRLSIGVELVAKPKLLVFLDEPT 1016

Query: 68   TGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLS-DSHIIYQGPR- 125
            +GLDS T + I   +R+     +  ++ ++ QP       FD ++ L      +Y G   
Sbjct: 1017 SGLDSQTAWSICKLIRKLADNGQ-AILCTIHQPSAILLAEFDRLLFLQRGGQTVYFGDLG 1075

Query: 126  ---EHVLEFFESIGF-KCPNRKGVADFLQEVT-----SRKDQEQY 161
                 ++ +FE  G  KCP     A+++ EV      S+ +Q+ Y
Sbjct: 1076 KNFTTLINYFEKYGAPKCPPEANPAEWMLEVIGAAPGSKANQDYY 1120


>PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin
          Length = 1511

 Score =  154 bits (388), Expect = 2e-36
 Identities = 89/271 (32%), Positives = 154/271 (55%), Gaps = 19/271 (7%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSI-IFMDEPTSGLDARA 696
            ++V++++E++   +A+VG+ G  GL++EQRKRLT+ VEL A P + +F+DEPTSGLD++ 
Sbjct: 987  EEVIKILEMEKYADAVVGVAGE-GLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGLDSQT 1045

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A  + + ++   + G+ ++CTIHQPS  + + FD LL +++GG+ +Y G LG     +I+
Sbjct: 1046 AWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLGEGCKTMID 1105

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYR--------INKA 808
            +FE   G  K     NPA WMLEV  ++       D+ E+++NSE YR        + + 
Sbjct: 1106 YFES-HGAHKCPADANPAEWMLEVVGAAPGSHANQDYYEVWRNSEEYRAVQSELDWMERE 1164

Query: 809  LVKELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVL 868
            L K+ S  A   K      ++S+S   Q      +    YWR+P+Y   +F+ +    + 
Sbjct: 1165 LPKKGSITAAEDK-----HEFSQSIIYQTKLVSIRLFQQYWRSPDYLWSKFILTIFNQLF 1219

Query: 869  LGSMFWDLGSKIEKEQDLFNAMGSMYSAVIL 899
            +G  F+  G+ +   Q L N M +++   ++
Sbjct: 1220 IGFTFFKAGTSL---QGLQNQMLAVFMFTVI 1247



 Score = 99.8 bits (247), Expect = 4e-20
 Identities = 45/147 (30%), Positives = 85/147 (57%)

Query: 12  NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLD 71
           N + +  +   GL    +T VGN ++R +SGG++KR++  E+ +  +K    D  + GLD
Sbjct: 281 NHLAEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLD 340

Query: 72  SSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEF 131
           S+T  + + +++    I   +  +++ Q   + Y+LF+ + +L D + IY GP +   ++
Sbjct: 341 SATALEFIRALKTQADISNTSATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKAKKY 400

Query: 132 FESIGFKCPNRKGVADFLQEVTSRKDQ 158
           FE +G+ CP+R+  ADFL  VTS  ++
Sbjct: 401 FEDMGYVCPSRQTTADFLTSVTSPSER 427



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 74/312 (23%), Positives = 122/312 (38%), Gaps = 39/312 (12%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L   RN  VG   V G+S  +RKR+++A   +        D  T GLD+  A   +R ++
Sbjct: 293 LSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALK 352

Query: 706 NTVDTGRT-VVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGV 764
              D   T     I+Q S D ++ F+++ +L  G Q IY GP    +     +FE +  V
Sbjct: 353 TQADISNTSATVAIYQCSQDAYDLFNKVCVLDDGYQ-IYYGP----ADKAKKYFEDMGYV 407

Query: 765 ----RKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKALVKEL------- 813
               +   D     T   E T +    + GI   +  K    Y +     KEL       
Sbjct: 408 CPSRQTTADFLTSVTSPSERTLNKDMLKKGIHIPQTPKEMNDYWVKSPNYKELMKEVDQR 467

Query: 814 -----SAPAPCSKDLYFPSQ---------YSRSFFTQCMACLWKQHWSYWRNPEYNAIRF 859
                 A     K+ +   Q         Y+ S+  Q    L +  W    N  +     
Sbjct: 468 LLNDDEASREAIKEAHIAKQSKRARPSSPYTVSYMMQVKYLLIRNMWRLRNNIGFTLFMI 527

Query: 860 LYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVI------LIGVMNCNSVQPVVA 913
           L + ++A++LGSMF+ +  K +     F    +M+ A++      L+ + +    +P+  
Sbjct: 528 LGNCSMALILGSMFFKIMKKGDTSTFYFRG-SAMFFAILFNAFSSLLEIFSLYEARPITE 586

Query: 914 VERTV-FYRESA 924
             RT   Y  SA
Sbjct: 587 KHRTYSLYHPSA 598



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 47/165 (28%), Positives = 86/165 (51%), Gaps = 14/165 (8%)

Query: 9    QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEIS 67
            +++N   + V+++L +E  AD VVG A    ++  Q+KRLT G E+   P   +F+DE +
Sbjct: 980  EEKNRYVEEVIKILEMEKYADAVVGVAG-EGLNVEQRKRLTIGVELTAKPKLLVFLDEPT 1038

Query: 68   TGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLS-DSHIIYQGPR- 125
            +GLDS T + I   M++  +  +  ++ ++ QP       FD ++ +      +Y G   
Sbjct: 1039 SGLDSQTAWSICQLMKKLANHGQ-AILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLG 1097

Query: 126  ---EHVLEFFESIG-FKCPNRKGVADFLQEVT-----SRKDQEQY 161
               + ++++FES G  KCP     A+++ EV      S  +Q+ Y
Sbjct: 1098 EGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQDYY 1142


>CDR1_CANAL (P43071) Multidrug resistance protein CDR1
          Length = 1501

 Score =  154 bits (388), Expect = 2e-36
 Identities = 104/325 (32%), Positives = 163/325 (50%), Gaps = 16/325 (4%)

Query: 640  VMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARAAA 698
            V++L+E+    +ALVG+ G  GL++EQRKRLT+ VELVA P ++ F+DEPTSGLD++ A 
Sbjct: 980  VIDLLEMTDYADALVGVAGE-GLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAW 1038

Query: 699  VVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHF 758
             + + +R   D G+ ++CTIHQPS  I   FD LL L++GG+  Y G LG N   +IN+F
Sbjct: 1039 SICKLMRKLADHGQAILCTIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYF 1098

Query: 759  EGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKALVKELSA--- 815
            E   G        NPA WML+V  ++       D+ E+++NS  Y+  +  +  + A   
Sbjct: 1099 EK-YGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAELS 1157

Query: 816  PAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMFWD 875
              P   D     +Y+   + Q +   W+     WR+P Y   +     + A+  G  F+ 
Sbjct: 1158 KLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSKIFLVVSAALFNGFSFFK 1217

Query: 876  LGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYFSICL 935
              + +   Q L N M S++   I    +    + P    +R V+    A    F +    
Sbjct: 1218 AKNNM---QGLQNQMFSVFMFFIPFNTL-VQQMLPYFVKQRDVYEVREAPSRTFSW-FAF 1272

Query: 936  WAGKYPSPICFCTSCG-----LWHY 955
             AG+  S I +  + G      W+Y
Sbjct: 1273 IAGQITSEIPYQVAVGTIAFFCWYY 1297



 Score = 95.1 bits (235), Expect = 9e-19
 Identities = 46/145 (31%), Positives = 83/145 (56%)

Query: 23  GLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTFQIVNSM 82
           GL    +T VGN  +R +SGG++KR++  E  +        D  + GLDS+T  + + ++
Sbjct: 286 GLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRAL 345

Query: 83  RQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESIGFKCPNR 142
           +    IL  T +I++ Q   + Y+LFD +++L + + I+ G      E+FE +G+KCP R
Sbjct: 346 KTSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQR 405

Query: 143 KGVADFLQEVTSRKDQEQYCEHKDR 167
           +  ADFL  +T+  ++E    ++D+
Sbjct: 406 QTTADFLTSLTNPAEREPLPGYEDK 430



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 43/144 (29%), Positives = 72/144 (49%), Gaps = 9/144 (6%)

Query: 16   DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSST 74
            DYV+ +L +   AD +VG A    ++  Q+KRLT G E++  P   LF+DE ++GLDS T
Sbjct: 978  DYVIDLLEMTDYADALVGVAG-EGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQT 1036

Query: 75   TFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGPR----EHVL 129
             + I   MR+     +  ++ ++ QP       FD ++ L       Y G      + ++
Sbjct: 1037 AWSICKLMRKLADHGQ-AILCTIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMI 1095

Query: 130  EFFESIGF-KCPNRKGVADFLQEV 152
             +FE  G   CP     A+++ +V
Sbjct: 1096 NYFEKYGADPCPKEANPAEWMLQV 1119



 Score = 49.7 bits (117), Expect = 4e-05
 Identities = 71/312 (22%), Positives = 128/312 (40%), Gaps = 43/312 (13%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L   RN  VG   V G+S  +RKR+++A   ++  +I   D  T GLD+  A   +R ++
Sbjct: 287 LSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALK 346

Query: 706 -NTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGV 764
            + V    T +  I+Q S D ++ FD++++L +G Q I+ G     ++    +FE +   
Sbjct: 347 TSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGYQ-IFFG----KATKAKEYFEKMGW- 400

Query: 765 RKIKDGYNPATWMLEVTTSSKEREL----------GIDFAELYKNSELY----------- 803
            K       A ++  +T  ++   L            +F   +KNS  Y           
Sbjct: 401 -KCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYF 459

Query: 804 ----RINKALVKELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRF 859
               R N       S  A  S +    S Y+ SFF Q    + +       +P       
Sbjct: 460 VECERSNTRETYRESHVAKQSNNTRPASPYTVSFFMQVRYGVARNFLRMKGDPSIPIFSV 519

Query: 860 LYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVI------LIGVMNCNSVQPVVA 913
                + ++L S+F++L    +     +    +M+ AV+      L+ +M+    +P+V 
Sbjct: 520 FGQLVMGLILSSVFYNLS---QTTGSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVE 576

Query: 914 V-ERTVFYRESA 924
             ++   YR SA
Sbjct: 577 KHKKYALYRPSA 588


>CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1
            (Pleomorphic drug resistance homolog)
          Length = 1542

 Score =  151 bits (382), Expect = 8e-36
 Identities = 89/267 (33%), Positives = 148/267 (55%), Gaps = 11/267 (4%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSI-IFMDEPTSGLDARA 696
            + V++++E++   +A+VG+PG  GL++EQRKRLT+ VEL A P + +F+DEPTSGLD++ 
Sbjct: 1003 EAVIKILEMETYADAVVGVPGE-GLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQT 1061

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A    + ++   + G+ ++CTIHQPS  + + FD LL L++GGQ +Y G LG     +I 
Sbjct: 1062 AWATCQLMKKLANHGQAILCTIHQPSAMLMQEFDRLLFLQKGGQTVYFGDLGKGCKTMIK 1121

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINK----ALVKE 812
            +FE   G  K     NPA WMLEV  ++       D+ E+++NSE ++  K     + KE
Sbjct: 1122 YFED-HGAHKCPPDANPAEWMLEVVGAAPGSHANQDYHEVWRNSEQFKQVKQELEQMEKE 1180

Query: 813  LSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSM 872
            LS       D     +++ S + Q      +    YWR P+Y   +++ +    + +G  
Sbjct: 1181 LS-QKELDNDEDANKEFATSLWYQFQLVCVRLFQQYWRTPDYLWSKYILTIFNQLFIGFT 1239

Query: 873  FWDLGSKIEKEQDLFNAMGSMYSAVIL 899
            F+     +   Q L N M S++   ++
Sbjct: 1240 FFKADHTL---QGLQNQMLSIFMYTVI 1263



 Score =  108 bits (270), Expect = 8e-23
 Identities = 50/156 (32%), Positives = 89/156 (57%)

Query: 12  NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLD 71
           N +TD  +   GL    DT VGN ++R +SGG++KR++  E+ +  +K    D  + GLD
Sbjct: 280 NHVTDVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVWICGSKFQCWDNATRGLD 339

Query: 72  SSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEF 131
           S+T  + V +++   HI K    +++ Q   + YNLF+ + +L + + IY G  +H   +
Sbjct: 340 SATALEFVRALKTQAHIAKNVATVAIYQCSQDAYNLFNKVSVLYEGYQIYFGDAQHAKVY 399

Query: 132 FESIGFKCPNRKGVADFLQEVTSRKDQEQYCEHKDR 167
           F+ +G+ CP R+ + DFL  +TS  ++    E+ D+
Sbjct: 400 FQKMGYFCPKRQTIPDFLTSITSPAERRINKEYLDK 435



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 76/311 (24%), Positives = 122/311 (38%), Gaps = 37/311 (11%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L   R+  VG   V G+S  +RKR+++A   +        D  T GLD+  A   +R ++
Sbjct: 292 LSHTRDTKVGNDLVRGVSGGERKRVSIAEVWICGSKFQCWDNATRGLDSATALEFVRALK 351

Query: 706 NTVDTGRTV-VCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGV 764
                 + V    I+Q S D +  F+++ +L +G Q IY G   H               
Sbjct: 352 TQAHIAKNVATVAIYQCSQDAYNLFNKVSVLYEGYQ-IYFGDAQHAKVYFQKMGYFCPKR 410

Query: 765 RKIKDGYNPATWMLEVTTSSKERELGI-------DFAELYKNSELYRINKALVKELSAP- 816
           + I D     T   E   + +  + GI       D  E + NSE Y+  +  + E  A  
Sbjct: 411 QTIPDFLTSITSPAERRINKEYLDKGIKVPQTPLDMVEYWHNSEEYKQLREEIDETLAHQ 470

Query: 817 -------------APCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYST 863
                        A  SK     S Y  S+  Q    L +  W    +      +   ++
Sbjct: 471 SEDDKEEIKEAHIAKQSKRARPSSPYVVSYMMQVKYILIRNFWRIKNSASVTLFQVFGNS 530

Query: 864 AVAVLLGSMFWDLGSKIEK--EQDLFNAMG-SMYSAVI------LIGVMNCNSVQPVVAV 914
           A+A +LGSMF+    KI+K    D F   G +M+ A++      L+ + +    +P+   
Sbjct: 531 AMAFILGSMFY----KIQKGSSADTFYFRGAAMFFAILFNAFSSLLEIFSLYEARPITEK 586

Query: 915 ERTV-FYRESA 924
            RT   Y  SA
Sbjct: 587 HRTYSLYHPSA 597



 Score = 52.8 bits (125), Expect = 5e-06
 Identities = 42/151 (27%), Positives = 78/151 (50%), Gaps = 9/151 (5%)

Query: 9    QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEIS 67
            +++N   + V+++L +E  AD VVG      ++  Q+KRLT G E+   P   +F+DE +
Sbjct: 996  EEKNEYVEAVIKILEMETYADAVVG-VPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPT 1054

Query: 68   TGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGPR- 125
            +GLDS T +     M++  +  +  ++ ++ QP       FD ++ L      +Y G   
Sbjct: 1055 SGLDSQTAWATCQLMKKLANHGQ-AILCTIHQPSAMLMQEFDRLLFLQKGGQTVYFGDLG 1113

Query: 126  ---EHVLEFFESIG-FKCPNRKGVADFLQEV 152
               + ++++FE  G  KCP     A+++ EV
Sbjct: 1114 KGCKTMIKYFEDHGAHKCPPDANPAEWMLEV 1144


>PDRA_YEAST (P51533) ATP-dependent permease PDR10
          Length = 1564

 Score =  150 bits (379), Expect = 2e-35
 Identities = 87/253 (34%), Positives = 142/253 (55%), Gaps = 8/253 (3%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSI-IFMDEPTSGLDARA 696
            ++V+E++E+K   +A+VG+PG  GL++EQRKRLT+ VEL A P + +F+DEPTSGLD++ 
Sbjct: 1041 EEVIEVLEMKLYADAIVGVPGE-GLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQT 1099

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A    + ++     G+ ++CTIHQPS  + + FD LL L++GGQ +Y G LG     +IN
Sbjct: 1100 AWSTCQLMKKLASRGQAILCTIHQPSALLMQEFDRLLFLQEGGQTVYFGELGKGCKTMIN 1159

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYR-INKAL---VKE 812
            +FE   G  K     NPA WMLE+  ++       D+  ++++SE YR + K L    +E
Sbjct: 1160 YFEA-HGAHKCPPDANPAEWMLEIVGAAPGTHASQDYFAIWRDSEEYREMQKELDWMERE 1218

Query: 813  LSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSM 872
            L      S +     +++ S   Q     ++    YWR P Y   +F  +    + +G  
Sbjct: 1219 LPKRTEGSSN-EEQKEFATSTLYQIKLVSYRLFHQYWRTPFYLWSKFFSTIVSELFIGFT 1277

Query: 873  FWDLGSKIEKEQD 885
            F+   + ++  Q+
Sbjct: 1278 FFKANTSLQGLQN 1290



 Score =  101 bits (251), Expect = 1e-20
 Identities = 45/145 (31%), Positives = 84/145 (57%)

Query: 14  ITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSS 73
           +T+  +   GL   ADT VGN  +R +SGG++KR++  E+ +  +K    D  + GLDS+
Sbjct: 303 MTEVAMATYGLSHTADTKVGNDFVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSA 362

Query: 74  TTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFE 133
           T  + + +++    I K    +++ Q   + Y+LFD + +L D + I+ GP +   ++F+
Sbjct: 363 TALEFIKALKTQATITKSAATVAIYQCSKDAYDLFDKVCVLYDGYQIFFGPSKQAKKYFQ 422

Query: 134 SIGFKCPNRKGVADFLQEVTSRKDQ 158
            +G+ CP R+  AD+L  +TS  ++
Sbjct: 423 RMGYVCPERQTTADYLTSITSPSER 447



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 69/313 (22%), Positives = 126/313 (40%), Gaps = 41/313 (13%)

Query: 654 VGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVRNTVD-TGR 712
           VG   V G+S  +RKR+++A   +        D  T GLD+  A   ++ ++     T  
Sbjct: 321 VGNDFVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIKALKTQATITKS 380

Query: 713 TVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGVRKIKDGYN 772
                I+Q S D ++ FD++ +L  G Q I+ GP    S     +F+ +  V    +   
Sbjct: 381 AATVAIYQCSKDAYDLFDKVCVLYDGYQ-IFFGP----SKQAKKYFQRMGYV--CPERQT 433

Query: 773 PATWMLEVTTSS---KEREL----------GIDFAELYKNSELYR-----INKALVKELS 814
            A ++  +T+ S   K++++            +  + +  SE Y+     +NK L  + S
Sbjct: 434 TADYLTSITSPSERIKDKDMVKHGIMIPQTAYEMNQYWIQSEEYKQLQVQVNKHLDTDSS 493

Query: 815 APAPCSKDLYFPSQ---------YSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAV 865
                 K+ +   Q         Y+ SFF Q    L +  W    +P       L   A+
Sbjct: 494 QQREQIKNAHIAKQSKRARPSSPYTVSFFLQVKYILIRDIWRIKNDPSIQLFTVLSHAAM 553

Query: 866 AVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVI-----LIGVMNCNSVQPVVAVERTV-F 919
           A++LGSMF+++          +      ++ +      L+ + +    +P+    +T   
Sbjct: 554 ALILGSMFYEVMLSTTTTTFYYRGAAIFFAILFNAFSSLLEIFSLYETRPITEKHKTYSL 613

Query: 920 YRESAAGNVFYFS 932
           YR SA      FS
Sbjct: 614 YRPSADAFASTFS 626



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 40/152 (26%), Positives = 79/152 (51%), Gaps = 11/152 (7%)

Query: 9    QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEIS 67
            ++++   + V+ VL +++ AD +VG      ++  Q+KRLT G E+   P   +F+DE +
Sbjct: 1034 EEKDKYVEEVIEVLEMKLYADAIVG-VPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPT 1092

Query: 68   TGLDSSTTFQIVNSMRQYVHILKGTVVI-SLLQPPPETYNLFDDIILLSD-SHIIYQGPR 125
            +GLDS T +     M++     +G  ++ ++ QP       FD ++ L +    +Y G  
Sbjct: 1093 SGLDSQTAWSTCQLMKKLAS--RGQAILCTIHQPSALLMQEFDRLLFLQEGGQTVYFGEL 1150

Query: 126  ----EHVLEFFESIG-FKCPNRKGVADFLQEV 152
                + ++ +FE+ G  KCP     A+++ E+
Sbjct: 1151 GKGCKTMINYFEAHGAHKCPPDANPAEWMLEI 1182


>PDRF_YEAST (Q04182) ATP-dependent permease PDR15
          Length = 1529

 Score =  149 bits (376), Expect = 4e-35
 Identities = 90/272 (33%), Positives = 152/272 (55%), Gaps = 21/272 (7%)

Query: 638  QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSI-IFMDEPTSGLDARA 696
            ++V++++E++   +A+VG+ G  GL++EQRKRLT+ VEL A P + +F+DEPTSGLD++ 
Sbjct: 1002 EEVIKILEMQQYSDAVVGVAGE-GLNVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQT 1060

Query: 697  AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
            A    + +R     G+ ++CTIHQPS  + + FD LL L++GGQ +Y G LG     +I+
Sbjct: 1061 AWDTCQLMRKLATHGQAILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTMID 1120

Query: 757  HFEGIQGVRKIKDGYNPATWMLEVTTSSKERELGIDFAELYKNSELYRINKALVKELS-- 814
            +FE  +G  K     NPA WMLEV  ++       D+ E+++NS+ Y   KA+ +EL   
Sbjct: 1121 YFES-KGAHKCPPDANPAEWMLEVVGAAPGSHATQDYNEVWRNSDEY---KAVQEELDWM 1176

Query: 815  -------APAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAV 867
                   +  P +++      ++ S + Q      +    YWR+P+Y   +F+ +    V
Sbjct: 1177 EKNLPGRSKEPTAEE---HKPFAASLYYQFKMVTIRLFQQYWRSPDYLWSKFILTIFNQV 1233

Query: 868  LLGSMFWDLGSKIEKEQDLFNAMGSMYSAVIL 899
             +G  F+     +   Q L N M S++   ++
Sbjct: 1234 FIGFTFFKADRSL---QGLQNQMLSIFMYTVI 1262



 Score =  100 bits (250), Expect = 2e-20
 Identities = 45/143 (31%), Positives = 82/143 (56%)

Query: 12  NLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLD 71
           N +T+  +   GL    DT VGN ++R +SGG++KR++  E+ +   +    D  + GLD
Sbjct: 291 NHVTEVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGLD 350

Query: 72  SSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEF 131
           S+T  + + +++    I K    +++ Q   + Y+LFD + +L D + +Y GP +   ++
Sbjct: 351 SATALEFIRALKTQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQLYFGPAKDAKKY 410

Query: 132 FESIGFKCPNRKGVADFLQEVTS 154
           F+ +G+ CP R+  ADFL  +TS
Sbjct: 411 FQDMGYYCPPRQTTADFLTSITS 433



 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 75/330 (22%), Positives = 129/330 (38%), Gaps = 33/330 (10%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L   R+  VG   V G+S  +RKR+++A   +        D  T GLD+  A   +R ++
Sbjct: 303 LSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGLDSATALEFIRALK 362

Query: 706 NTVDTGRT-VVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGV 764
              D G+T     I+Q S D ++ FD++ +L  G Q +Y GP         +        
Sbjct: 363 TQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQ-LYFGPAKDAKKYFQDMGYYCPPR 421

Query: 765 RKIKDGYNPATWMLEVTTSSKERELGI-------DFAELYKNSELYR-----INKALVKE 812
           +   D     T   E   S +  E G        D AE +  SE Y+     I+  L K 
Sbjct: 422 QTTADFLTSITSPTERIISKEFIEKGTRVPQTPKDMAEYWLQSESYKNLIKDIDSTLEKN 481

Query: 813 LSAPAPCSKDLYFPSQYSR---------SFFTQCMACLWKQHWSYWRNPEYNAIRFLYST 863
                   +D +   Q  R         ++  Q    L +  W   ++      + + ++
Sbjct: 482 TDEARNIIRDAHHAKQAKRAPPSSPYVVNYGMQVKYLLIRNFWRMKQSASVTLWQVIGNS 541

Query: 864 AVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVI------LIGVMNCNSVQPVVAVERT 917
            +A +LGSMF+ +  K +     F    +M+ A++      L+ + +    +P+    RT
Sbjct: 542 VMAFILGSMFYKVMKKNDTSTFYFRG-AAMFFAILFNAFSCLLEIFSLYETRPITEKHRT 600

Query: 918 V-FYRESAAGNVFYFSICLWAGKYPSPICF 946
              Y  SA  + F   +     K  + +CF
Sbjct: 601 YSLYHPSA--DAFASVLSEMPPKLITAVCF 628



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 43/151 (28%), Positives = 79/151 (51%), Gaps = 9/151 (5%)

Query: 9    QKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTG-EMLVGPTKALFMDEIS 67
            +++N   + V+++L ++  +D VVG A    ++  Q+KRLT G E+   P   +F+DE +
Sbjct: 995  EEKNRYVEEVIKILEMQQYSDAVVGVAG-EGLNVEQRKRLTIGVELAARPKLLVFLDEPT 1053

Query: 68   TGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILL-SDSHIIYQGPR- 125
            +GLDS T +     MR+ +      ++ ++ QP       FD ++ L      +Y G   
Sbjct: 1054 SGLDSQTAWDTCQLMRK-LATHGQAILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLG 1112

Query: 126  ---EHVLEFFESIG-FKCPNRKGVADFLQEV 152
               + ++++FES G  KCP     A+++ EV
Sbjct: 1113 EGCKTMIDYFESKGAHKCPPDANPAEWMLEV 1143


>WHIT_DROME (P10090) White protein
          Length = 687

 Score =  117 bits (293), Expect = 2e-25
 Identities = 89/306 (29%), Positives = 157/306 (51%), Gaps = 23/306 (7%)

Query: 630 VPRHQC*NQKVMEL------VELKPLRNALVGLPG-VCGLSMEQRKRLTVAVELVANPSI 682
           +PRH    Q+V  +      + L   ++ ++G+PG V GLS  +RKRL  A E + +P +
Sbjct: 202 MPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPL 261

Query: 683 IFMDEPTSGLDARAAAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEI 742
           +  DEPTSGLD+  A  V++ ++     G+TV+ TIHQPS ++FE FD++LL+ + G+  
Sbjct: 262 LICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAE-GRVA 320

Query: 743 YVGPLGHNSSNLINHFEGIQGVRKIKDGYNPATWMLEV--TTSSKERELGIDFAELYKNS 800
           ++G      S  ++ F  +    +    YNPA + ++V      +E E     A++  N 
Sbjct: 321 FLG----TPSEAVDFFSYVGA--QCPTNYNPADFYVQVLAVVPGREIESRDRIAKICDNF 374

Query: 801 ELYRINKALVKELSAPAPCSKDLYFPSQ---YSRSFFTQCMACLWKQHWSYWRNPEYNAI 857
            + ++ + + ++L A     K L  P     Y  ++F Q  A LW+   S  + P    +
Sbjct: 375 AISKVARDM-EQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKV 433

Query: 858 RFLYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERT 917
           R + +T VA+L+G +F  LG ++  +  + N  G+++  +  +   N  +   V   E  
Sbjct: 434 RLIQTTMVAILIGLIF--LGQQL-TQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELP 490

Query: 918 VFYRES 923
           VF RE+
Sbjct: 491 VFMREA 496



 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 43/138 (31%), Positives = 75/138 (54%), Gaps = 2/138 (1%)

Query: 16  DYVLRVLGLEICADTVVG-NAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSST 74
           D V++ L L  C  T++G    ++ +SGG++KRL      +     L  DE ++GLDS T
Sbjct: 216 DQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFT 275

Query: 75  TFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFES 134
              +V  +++     K TV++++ QP  E + LFD I+L+++  + + G     ++FF  
Sbjct: 276 AHSVVQVLKKLSQKGK-TVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSY 334

Query: 135 IGFKCPNRKGVADFLQEV 152
           +G +CP     ADF  +V
Sbjct: 335 VGAQCPTNYNPADFYVQV 352


>WHIT_CERCA (Q17320) White protein
          Length = 679

 Score =  117 bits (293), Expect = 2e-25
 Identities = 92/306 (30%), Positives = 154/306 (50%), Gaps = 22/306 (7%)

Query: 630 VPRHQC*NQKVMEL------VELKPLRNALVGLPG-VCGLSMEQRKRLTVAVELVANPSI 682
           +PRH    QKV  +      + L   +N L+G+PG V GLS  +RKRL  A E + +P +
Sbjct: 193 MPRHMTQKQKVQRVDQVIQDLSLGKCQNTLIGVPGRVKGLSGGERKRLAFASEALTDPPL 252

Query: 683 IFMDEPTSGLDARAAAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEI 742
           +  DEPTSGLD+  A  V++ ++     G+TV+ TIHQPS ++FE FD++LL+ + G+  
Sbjct: 253 LICDEPTSGLDSFMAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAE-GRVA 311

Query: 743 YVGPLGHNSSNLINHFEGIQGVRKIKDGYNPATWMLEV--TTSSKERELGIDFAELYKNS 800
           ++G  G      ++ F  I         Y PA + ++V      +E E     A++  N 
Sbjct: 312 FLGTPG----EAVDFFSYIGAT--CPTNYTPADFYVQVLAVVPGREVESRDRVAKICDNF 365

Query: 801 ELYRINKAL---VKELSAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAI 857
            + ++++ +    ++L       K+      Y  S+F Q  A LW+   S  + P    +
Sbjct: 366 AVGKVSREMEQNFQKLVKSNGFGKEDENEYTYKASWFMQFRAVLWRSWLSVLKEPLLVKV 425

Query: 858 RFLYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERT 917
           R L +T VAVL+G +F  LG ++  +  + N  G+++  +  +   N  +   V   E  
Sbjct: 426 RLLQTTMVAVLIGLIF--LGQQL-TQVGVMNINGAIFLFLTNMTFQNSFATITVFTTELP 482

Query: 918 VFYRES 923
           VF RE+
Sbjct: 483 VFMRET 488



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 46/148 (31%), Positives = 79/148 (53%), Gaps = 3/148 (2%)

Query: 6   TEGQKENLITDYVLRVLGLEICADTVVG-NAMIRAISGGQKKRLTTGEMLVGPTKALFMD 64
           T+ QK   + D V++ L L  C +T++G    ++ +SGG++KRL      +     L  D
Sbjct: 198 TQKQKVQRV-DQVIQDLSLGKCQNTLIGVPGRVKGLSGGERKRLAFASEALTDPPLLICD 256

Query: 65  EISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGP 124
           E ++GLDS     +V  +++     K TV++++ QP  E + LFD I+L+++  + + G 
Sbjct: 257 EPTSGLDSFMAHSVVQVLKKLSQKGK-TVILTIHQPSSELFELFDKILLMAEGRVAFLGT 315

Query: 125 REHVLEFFESIGFKCPNRKGVADFLQEV 152
               ++FF  IG  CP     ADF  +V
Sbjct: 316 PGEAVDFFSYIGATCPTNYTPADFYVQV 343


>WHIT_LUCCU (Q05360) White protein
          Length = 677

 Score =  115 bits (288), Expect = 6e-25
 Identities = 85/292 (29%), Positives = 149/292 (50%), Gaps = 17/292 (5%)

Query: 639 KVMELVELKPLRNALVGLPG-VCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAA 697
           +V++ + L   +N ++G+PG V GLS  +RKRL  A E + +P ++  DEPTSGLD+  A
Sbjct: 206 QVIQDLSLIKCQNTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFMA 265

Query: 698 AVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINH 757
           A V++ ++     G+TV+ TIHQPS ++FE FD++LL+ +G       P+       ++ 
Sbjct: 266 ASVVQVLKKLSQRGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPV-----EAVDF 320

Query: 758 FEGIQGVRKIKDGYNPATWMLEV--TTSSKERELGIDFAELYKNSELYRINKALVKELSA 815
           F  I    +    YNPA + ++V      +E E     +++  N  + ++++ + +    
Sbjct: 321 FSFIGA--QCPTNYNPADFYVQVLAVVPGREIESRDRISKICDNFAVGKVSREMEQNFQK 378

Query: 816 PAP----CSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGS 871
            A       KD      Y  S+FTQ  A +W+   S  + P    +R + +T VAVL+G 
Sbjct: 379 IAAKTDGLQKDDETTILYKASWFTQFRAIMWRSWISTLKEPLLVKVRLIQTTMVAVLIGL 438

Query: 872 MFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRES 923
           +F    ++   +  + N  G+++  +  +   N  +V  V   E  VF RE+
Sbjct: 439 IFL---NQPMTQVGVMNINGAIFLFLTNMTFQNVFAVINVFTSELPVFMRET 487



 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 47/153 (30%), Positives = 81/153 (52%), Gaps = 3/153 (1%)

Query: 1   MKAVATEGQKENLITDYVLRVLGLEICADTVVG-NAMIRAISGGQKKRLTTGEMLVGPTK 59
           M    T+ QK   + D V++ L L  C +T++G    ++ +SGG++KRL      +    
Sbjct: 191 MPRTMTQKQKLQRV-DQVIQDLSLIKCQNTIIGVPGRVKGLSGGERKRLAFASEALTDPP 249

Query: 60  ALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHI 119
            L  DE ++GLDS     +V  +++     K TV++++ QP  E + LFD I+L+++  +
Sbjct: 250 LLICDEPTSGLDSFMAASVVQVLKKLSQRGK-TVILTIHQPSSELFELFDKILLMAEGRV 308

Query: 120 IYQGPREHVLEFFESIGFKCPNRKGVADFLQEV 152
            + G     ++FF  IG +CP     ADF  +V
Sbjct: 309 AFLGTPVEAVDFFSFIGAQCPTNYNPADFYVQV 341


>ABG4_HUMAN (Q9H172) ATP-binding cassette, sub-family G, member 4
          Length = 646

 Score =  114 bits (286), Expect = 1e-24
 Identities = 87/301 (28%), Positives = 145/301 (47%), Gaps = 17/301 (5%)

Query: 662 LSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVRNTVDTGRTVVCTIHQP 721
           LS  QRKRL +A+ELV NP ++F DEPTSGLD+ +   V+  +++    GRT++CTIHQP
Sbjct: 201 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQP 260

Query: 722 SIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGVRKIKDGYNPATWMLEVT 781
           S  +FE FD+L +L Q GQ I+ G +    +NLI + +G+ G+      +NPA +++EV 
Sbjct: 261 SAKLFEMFDKLYILSQ-GQCIFKGVV----TNLIPYLKGL-GLH-CPTYHNPADFIIEVA 313

Query: 782 TSSKERELGIDFAELYKNSELYRINKALVKELSAPAPC-----SKDLYFPSQYSRSFFTQ 836
           +        + F  +          K+  ++   PAPC       D      ++ S  TQ
Sbjct: 314 SGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQ 373

Query: 837 CMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMFWDLGSKIEKEQDLFNAMGSMYSA 896
                 +   S  R+     +RF+    + VL+G ++  +G    K   +FN  G ++ +
Sbjct: 374 FCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASK---VFNNTGCLFFS 430

Query: 897 VILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYFSICLWAGKYPSPICFCTSCGLWHYS 956
           ++ +             +E  VF RE    N +Y     +  K  + + F   C + + S
Sbjct: 431 MLFLMFAALMPTVLTFPLEMAVFMREHL--NYWYSLKAYYLAKTMADVPFQVVCPVVYCS 488

Query: 957 V 957
           +
Sbjct: 489 I 489



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 47/145 (32%), Positives = 81/145 (55%), Gaps = 7/145 (4%)

Query: 10  KENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTG 69
           K+ L+T+ +L  LGL  C+ T         +SGGQ+KRL     LV     +F DE ++G
Sbjct: 177 KKELVTE-ILTALGLMSCSHTRTA-----LLSGGQRKRLAIALELVNNPPVMFFDEPTSG 230

Query: 70  LDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVL 129
           LDS++ FQ+V+ M+      + T++ ++ QP  + + +FD + +LS    I++G   +++
Sbjct: 231 LDSASCFQVVSLMKSLAQGGR-TIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLI 289

Query: 130 EFFESIGFKCPNRKGVADFLQEVTS 154
            + + +G  CP     ADF+ EV S
Sbjct: 290 PYLKGLGLHCPTYHNPADFIIEVAS 314


>WHIT_ANOGA (Q27256) White protein
          Length = 695

 Score =  107 bits (267), Expect = 2e-22
 Identities = 80/296 (27%), Positives = 146/296 (49%), Gaps = 21/296 (7%)

Query: 638 QKVMELVELKPLRNALVGLPG-VCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARA 696
           Q+V++ + L    + ++G PG + GLS  +RKRL  A E + +P ++  DEPTSGLD+  
Sbjct: 219 QEVLQELSLVKCADTIIGAPGRIKGLSGGERKRLAFASETLTDPHLLLCDEPTSGLDSFM 278

Query: 697 AAVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLIN 756
           A  V++ ++     G+T++ TIHQPS +++  FD++LL+ +G       P  + S+   +
Sbjct: 279 AHSVLQVLKGMAMKGKTIILTIHQPSSELYCLFDKILLVAEGRVAFLGSP--YQSAEFFS 336

Query: 757 HFEGIQGVRKIKDGYNPATWMLEV--TTSSKERELGIDFAELYKNSELYRINKALVKELS 814
              GI         YNPA + +++     +KE E      ++  +  +  I + +++  S
Sbjct: 337 QL-GI----PCPPNYNPADFYVQMLAIAPAKEAECRDMIKKICDSFAVSPIAREVLETAS 391

Query: 815 APAPCSKDLYFPSQ--------YSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVA 866
                  + Y   Q        Y  S++TQ    LW+   S  ++P    +R L +  VA
Sbjct: 392 VAGKGMDEPYMLQQVEGVGSTGYRSSWWTQFYCILWRSWLSVLKDPMLVKVRLLQTAMVA 451

Query: 867 VLLGSMFWDLGSKIEKEQDLFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRE 922
            L+GS+++    ++  +  + N  GS++  +  +   N  +V  V + E  VF RE
Sbjct: 452 TLIGSIYF---GQVLDQDGVMNINGSLFLFLTNMTFQNVFAVINVFSAELPVFLRE 504



 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 45/133 (33%), Positives = 72/133 (53%), Gaps = 4/133 (3%)

Query: 18  VLRVLGLEICADTVVGN-AMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTTF 76
           VL+ L L  CADT++G    I+ +SGG++KRL      +     L  DE ++GLDS    
Sbjct: 221 VLQELSLVKCADTIIGAPGRIKGLSGGERKRLAFASETLTDPHLLLCDEPTSGLDSFMAH 280

Query: 77  QIVNSMRQYVHILKG-TVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVLEFFESI 135
            ++  ++     +KG T+++++ QP  E Y LFD I+L+++  + + G      EFF  +
Sbjct: 281 SVLQVLKGMA--MKGKTIILTIHQPSSELYCLFDKILLVAEGRVAFLGSPYQSAEFFSQL 338

Query: 136 GFKCPNRKGVADF 148
           G  CP     ADF
Sbjct: 339 GIPCPPNYNPADF 351


>AUS1_YEAST (Q08409) ATP-dependent permease AUS1
          Length = 1394

 Score =  105 bits (262), Expect = 6e-22
 Identities = 77/294 (26%), Positives = 139/294 (47%), Gaps = 26/294 (8%)

Query: 659  VCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARAAAVVMRTVRNTVDTGRTVVCT 717
            V  L+  QRK L++ VELV  PS++ F+DEPTSGLDA AA  +++ ++     G+ + CT
Sbjct: 874  VADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCT 933

Query: 718  IHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGVRKIKDGYNPATWM 777
            IHQPS  +   FD + LLK+GG+ ++ GP+       ++H   +      K+  NPA ++
Sbjct: 934  IHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLV---YDKEHDNPADFV 990

Query: 778  LEVTTSSKE-------------RELGIDFAELYKNSELYRINKALVKELSAPAPCSKDLY 824
            ++   +S                +  ID++ L+++S   ++ K     L   A  S   Y
Sbjct: 991  IDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDY 1050

Query: 825  FPSQYSRSFFTQCMACLW-KQHWSYWRNPEYNAIRFLYSTAVAVLLGSMFWDLGSKIEKE 883
              S + +  + Q +A +  +Q+    R+  Y   ++  +    + +G  FW +   I   
Sbjct: 1051 TTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGL 1110

Query: 884  QD--LFNAMGSMYSAVILIGVMNCNSVQPVVAVERTVFYRESAAGNVFYFSICL 935
            QD   F  M    S+ ++      N +Q      + V+    A  N +++++ L
Sbjct: 1111 QDSIFFCFMALCVSSPLI------NQIQDKALKTKEVYVAREARSNTYHWTVLL 1158



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 37/147 (25%), Positives = 76/147 (51%), Gaps = 2/147 (1%)

Query: 7   EGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEI 66
           +G+++  I + +LR  GL     T+VGN   R +SGG++KR++  E  +        D  
Sbjct: 140 KGERDQ-IRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDNS 198

Query: 67  STGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPRE 126
           + GLDS+T    +  +R+     +   ++ + Q   +  + FD I++LSDS+ ++ G  +
Sbjct: 199 TKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFYGTVD 258

Query: 127 HVLEFF-ESIGFKCPNRKGVADFLQEV 152
             L +F +++G +      + ++L  +
Sbjct: 259 ECLTYFRDTLGIEKDPNDCIIEYLTSI 285



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 42/157 (26%), Positives = 68/157 (42%), Gaps = 12/157 (7%)

Query: 628 PVVPRHQC*NQKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDE 687
           P   R Q  N+ + E   L  +   +VG     G+S  +RKR+++    +AN S+   D 
Sbjct: 139 PKGERDQIRNELLREF-GLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDN 197

Query: 688 PTSGLDARAAAVVMRTVRNTVDTGRTV-VCTIHQPSIDIFESFDELLLLKQGGQEIYVGP 746
            T GLD+  A   +  +R      R+V +  I Q S  I + FD++L+L    Q  Y   
Sbjct: 198 STKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFY--- 254

Query: 747 LGHNSSNLINHFEGIQGVRKIKDGYNPATWMLEVTTS 783
                   + +F    G+ K     +P   ++E  TS
Sbjct: 255 --GTVDECLTYFRDTLGIEK-----DPNDCIIEYLTS 284



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 36/133 (27%), Positives = 65/133 (48%), Gaps = 9/133 (6%)

Query: 10  KENLITDYVLRVLGLEICADTVVG------NAMIRAISGGQKKRLTTG-EMLVGPTKALF 62
           KE+L    +LR  G     DTV        + ++  ++  Q+K L+ G E++  P+  LF
Sbjct: 841 KESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLF 900

Query: 63  MDEISTGLDSSTTFQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLS-DSHIIY 121
           +DE ++GLD+     IV  ++Q + +    +  ++ QP     + FD+I LL      ++
Sbjct: 901 LDEPTSGLDAEAALTIVKFLKQ-LSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVF 959

Query: 122 QGPREHVLEFFES 134
            GP +    +F S
Sbjct: 960 FGPMDDACGYFMS 972


>PDRB_YEAST (P40550) ATP-dependent permease PDR11
          Length = 1410

 Score =  103 bits (257), Expect = 2e-21
 Identities = 85/310 (27%), Positives = 139/310 (44%), Gaps = 44/310 (14%)

Query: 659  VCGLSMEQRKRLTVAVELVANPSII-FMDEPTSGLDARAAAVVMRTVRNTVDTGRTVVCT 717
            V  LS  QRK L++ VELV  PS++ F+DEPTSGLDA AA  +++ ++     G+ ++CT
Sbjct: 873  VADLSPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVQFLKKLSMQGQAILCT 932

Query: 718  IHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGVRKIKDGYNPATWM 777
            IHQPS  +   FD + LLK+GG+ +Y G L +     + H   +   R++    NPA ++
Sbjct: 933  IHQPSKSVISYFDNIYLLKRGGECVYFGSLPNACDYFVAHDRRLTFDREMD---NPADFV 989

Query: 778  LEVT---------------TSSK--------ERELGIDFAELYKNS-ELYRINKALVKEL 813
            ++V                TSSK        ++   I++AEL+++S E  R+   L+   
Sbjct: 990  IDVVGSGSTNIPMDDAEKPTSSKIDEPVSYHKQSDSINWAELWQSSPEKVRVADDLLLLE 1049

Query: 814  SAPAPCSKDLYFPSQYSRSFFTQCMACLWKQHWSYWRNPEYNAIRFLYSTAVAVLLGSMF 873
                    D         S+  Q      +Q+    R+  Y   ++  +    + +G  F
Sbjct: 1050 EEARKSGVDFTTSVWSPPSYMEQIKLITKRQYICTKRDMTYVFAKYALNAGAGLFIGFSF 1109

Query: 874  WDLGSKIEKEQDLFNAMGSMYSAVILIGVMNC------NSVQPVVAVERTVFYRESAAGN 927
            W     I   QD          A+ L  +M C      N VQ      + V+    A  N
Sbjct: 1110 WRTKHNINGLQD----------AIFLCFMMLCVSSPLINQVQDKALQSKEVYIAREARSN 1159

Query: 928  VFYFSICLWA 937
             +++++ L A
Sbjct: 1160 TYHWTVLLIA 1169



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 36/145 (24%), Positives = 70/145 (47%), Gaps = 1/145 (0%)

Query: 16  DYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDEISTGLDSSTT 75
           D +L+  GL     T VGN  +R +SGG++KR++  E  +        D  + GLDS+T 
Sbjct: 147 DELLKEFGLSHVKKTYVGNDYVRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATA 206

Query: 76  FQIVNSMRQYVHILKGTVVISLLQPPPETYNLFDDIILLSDSHIIYQGPREHVL-EFFES 134
            + ++  ++     +    + + Q   +  + FD I++L DS  ++ G  E  L  F ++
Sbjct: 207 LEFLSITQKMAKATRSVNFVKISQASDKIVSKFDKILMLGDSFQVFYGTMEECLTHFHDT 266

Query: 135 IGFKCPNRKGVADFLQEVTSRKDQE 159
           +  K      + ++L  + + K +E
Sbjct: 267 LQIKKNPNDCIIEYLTSILNFKFKE 291



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 38/139 (27%), Positives = 59/139 (42%), Gaps = 11/139 (7%)

Query: 646 LKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAAAVVMRTVR 705
           L  ++   VG   V G+S  +RKR+++    +AN S+   D  T GLD+  A   +   +
Sbjct: 155 LSHVKKTYVGNDYVRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALEFLSITQ 214

Query: 706 NTVDTGRTV-VCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINHFEGIQGV 764
                 R+V    I Q S  I   FD++L+L    Q  Y           + HF     +
Sbjct: 215 KMAKATRSVNFVKISQASDKIVSKFDKILMLGDSFQVFY-----GTMEECLTHFHDTLQI 269

Query: 765 RKIKDGYNPATWMLEVTTS 783
           +K     NP   ++E  TS
Sbjct: 270 KK-----NPNDCIIEYLTS 283



 Score = 42.0 bits (97), Expect = 0.009
 Identities = 26/99 (26%), Positives = 53/99 (53%), Gaps = 3/99 (3%)

Query: 36  MIRAISGGQKKRLTTG-EMLVGPTKALFMDEISTGLDSSTTFQIVNSMRQYVHILKGTVV 94
           ++  +S  Q+K L+ G E++  P+  LF+DE ++GLD+     IV  +++ + +    ++
Sbjct: 872 LVADLSPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVQFLKK-LSMQGQAIL 930

Query: 95  ISLLQPPPETYNLFDDIILLS-DSHIIYQGPREHVLEFF 132
            ++ QP     + FD+I LL      +Y G   +  ++F
Sbjct: 931 CTIHQPSKSVISYFDNIYLLKRGGECVYFGSLPNACDYF 969


>ABG8_HUMAN (Q9H221) ATP-binding cassette, sub-family G, member 8
           (Sterolin-2)
          Length = 673

 Score =  102 bits (254), Expect = 5e-21
 Identities = 57/159 (35%), Positives = 97/159 (60%), Gaps = 8/159 (5%)

Query: 6   TEGQKENLITDYVLRVLGLEICADTVVGNAMIRAISGGQKKRLTTGEMLVGPTKALFMDE 65
           ++ Q++  + D V+  L L  CADT VGN  +R +SGG+++R++ G  L+     L +DE
Sbjct: 180 SQAQRDKRVED-VIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDE 238

Query: 66  ISTGLDSSTTFQIVNSMRQYVHILKGT--VVISLLQPPPETYNLFDDIILLSDSHIIYQG 123
            ++GLDS T   +V ++ +   + KG   V+ISL QP  + + LFD ++L++    IY G
Sbjct: 239 PTSGLDSFTAHNLVKTLSR---LAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLG 295

Query: 124 PREHVLEFFESIGFKCPNRKGVADFLQEVTS--RKDQEQ 160
             +H++++F +IG+ CP     ADF  ++TS  R+ +EQ
Sbjct: 296 AAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQ 334



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 55/161 (34%), Positives = 89/161 (55%), Gaps = 22/161 (13%)

Query: 638 QKVMELVELKPLRNALVGLPGVCGLSMEQRKRLTVAVELVANPSIIFMDEPTSGLDARAA 697
           + V+  + L+   +  VG   V GLS  +R+R+++ V+L+ NP I+ +DEPTSGLD+  A
Sbjct: 189 EDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTA 248

Query: 698 AVVMRTVRNTVDTGRTVVCTIHQPSIDIFESFDELLLLKQGGQEIYVGPLGHNSSNLINH 757
             +++T+       R V+ ++HQP  DIF  FD L+LL   G  IY+G   H    ++ +
Sbjct: 249 HNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFD-LVLLMTSGTPIYLGAAQH----MVQY 303

Query: 758 FEGIQGVRKIKDGY------NPATWMLEVTT---SSKEREL 789
           F  I        GY      NPA + +++T+    S+E+EL
Sbjct: 304 FTAI--------GYPCPRYSNPADFYVDLTSIDRRSREQEL 336


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.341    0.149    0.502 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,675,347
Number of Sequences: 164201
Number of extensions: 4220417
Number of successful extensions: 15012
Number of sequences better than 10.0: 786
Number of HSP's better than 10.0 without gapping: 595
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 13316
Number of HSP's gapped (non-prelim): 1794
length of query: 1055
length of database: 59,974,054
effective HSP length: 121
effective length of query: 934
effective length of database: 40,105,733
effective search space: 37458754622
effective search space used: 37458754622
T: 11
A: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.9 bits)
S2: 71 (32.0 bits)