BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC147404.2 + phase: 0
(599 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
I5P2_HUMAN (P32019) Type II inositol-1,4,5-trisphosphate 5-phosp... 179 1e-44
OCRL_HUMAN (Q01968) Inositol polyphosphate 5-phosphatase OCRL-1 ... 168 4e-41
SYJ2_MOUSE (Q9D2G5) Synaptojanin 2 (EC 3.1.3.36) (Synaptic inosi... 156 2e-37
SYJ2_RAT (O55207) Synaptojanin 2 (EC 3.1.3.36) (Synaptic inosito... 153 1e-36
SYJ1_HUMAN (O43426) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosi... 153 1e-36
SYJ1_BOVIN (O18964) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosi... 152 2e-36
SYJ1_RAT (Q62910) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosito... 151 4e-36
SYJ1_MOUSE (Q8CHC4) Synaptojanin 1 (EC 3.1.3.36) (Synaptic inosi... 151 4e-36
YIA2_YEAST (P40559) Hypothetical 108.4 kDa protein in BET1-PAN1 ... 149 2e-35
SYJ2_HUMAN (O15056) Synaptojanin 2 (EC 3.1.3.36) (Synaptic inosi... 149 3e-35
YNK6_YEAST (P50942) Hypothetical 133.3 kDa protein in CYB5-LEU4 ... 147 6e-35
SYJ1_SCHPO (O43001) Synaptojanin homolog 1 (EC 3.1.3.36) (Inosit... 134 5e-31
P5PA_HUMAN (Q15735) Phosphatidylinositol 4,5-bisphosphate 5-phos... 116 1e-25
P5PA_RAT (Q9JMC1) Phosphatidylinositol 4,5-bisphosphate 5-phosph... 114 6e-25
P5PA_MOUSE (P59644) Phosphatidylinositol 4,5-bisphosphate 5-phos... 114 9e-25
INP5_RAT (Q9WVR1) 72 kDa inositol polyphosphate 5-phosphatase (E... 108 5e-23
INP5_MOUSE (Q9JII1) 72 kDa inositol polyphosphate 5-phosphatase ... 108 5e-23
INP5_HUMAN (Q9NRR6) 72 kDa inositol polyphosphate 5-phosphatase ... 97 2e-19
SKIP_MOUSE (Q8C5L6) Skeletal muscle and kidney enriched inositol... 96 3e-19
SKIP_HUMAN (Q9BT40) Skeletal muscle and kidney enriched inositol... 95 5e-19
>I5P2_HUMAN (P32019) Type II inositol-1,4,5-trisphosphate
5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide
5-phosphatase) (5PTase) (Fragment)
Length = 942
Score = 179 bits (455), Expect = 1e-44
Identities = 102/259 (39%), Positives = 150/259 (57%), Gaps = 11/259 (4%)
Query: 313 FSELANNEDANGIISVKSHP--KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVG 370
F + E+ +S HP KY ++ ++VGI + ++V+++ ++ ++ VG G
Sbjct: 342 FHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTG 401
Query: 371 LMGYMGNKGSVSVSMSVFQSRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDT 430
+MG MGNKG V++ + +C V SHLA+ ++ +RRN D +I R +F +
Sbjct: 402 IMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEE--YERRNQDYKDICSRMQFCQPDPS 459
Query: 431 DQPQKIPSHDKIFWFGDLNYRINMSDGE-IRKLVDLKKWNELMKFDQLSNELCKGHVFEG 489
P I +HD I W GDLNYRI D E ++KL++ K + L +DQL ++ VFEG
Sbjct: 460 LPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEG 519
Query: 490 WKEGLINFPPTYKYEFNSDKHVGGNTQEGEKRRAPAWCDRILWLGKGIKQLKYQS-AENQ 548
+ EG + F PTYKY+ SD + EK RAPAWCDRILW GK I QL YQS +
Sbjct: 520 FTEGELTFQPTYKYDTGSD-----DWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALK 574
Query: 549 LSDHRPVSSIFLVDVEVID 567
SDH+PVSS+F + V V++
Sbjct: 575 TSDHKPVSSVFDIGVRVVN 593
Score = 36.6 bits (83), Expect = 0.19
Identities = 22/67 (32%), Positives = 33/67 (48%), Gaps = 6/67 (8%)
Query: 72 KDYEMKRHRRRKSETLRAQYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTEEEPSDIY 131
+D +K H +K E Y + R GT+NV G+ P L + WL + D+Y
Sbjct: 273 RDTIVKSHLLQKEE----DYTYIQNFRFFAGTYNVNGQSPKECLRL--WLSNGIQAPDVY 326
Query: 132 IIGFQEV 138
+GFQE+
Sbjct: 327 CVGFQEL 333
>OCRL_HUMAN (Q01968) Inositol polyphosphate 5-phosphatase OCRL-1 (EC
3.1.3.36) (Lowe's oculocerebrorenal syndrome protein)
Length = 901
Score = 168 bits (425), Expect = 4e-41
Identities = 92/246 (37%), Positives = 138/246 (55%), Gaps = 9/246 (3%)
Query: 330 SHPKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQ 389
S KY ++ ++VG+ + ++ ++ R++ + VG G+MG MGNKG V+V
Sbjct: 307 SKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHN 366
Query: 390 SRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLN 449
+ C V SHLA+ +D +RRN D +I R F T I H+ + W GDLN
Sbjct: 367 TTFCIVNSHLAAHVED--FERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLN 424
Query: 450 YRINMSD-GEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSD 508
YR+ M D E++ L++ K L+KFDQL+ + + F + EG I F PTYKY+ +D
Sbjct: 425 YRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTD 484
Query: 509 KHVGGNTQEGEKRRAPAWCDRILWLGKGIKQLKYQS-AENQLSDHRPVSSIFLVDVEVID 567
+ K R PAWCDRILW G + QL Y+S E + SDH+PVS++F + V+V+D
Sbjct: 485 R-----WDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVD 539
Query: 568 HRKLER 573
R+ +
Sbjct: 540 ERRYRK 545
Score = 52.4 bits (124), Expect = 3e-06
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 4/82 (4%)
Query: 90 QYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTEEEPSDIYIIGFQEVVPLNAGNVFGA 149
+Y+N + R +GTWNV G+ P D +E WL + P DIY IGFQE + L+ F
Sbjct: 233 EYVNIQTFRFFVGTWNVNGQSP--DSGLEPWLNCDPNPPDIYCIGFQE-LDLSTEAFFYF 289
Query: 150 EDSKPIPKWDALIRRTLNKSSE 171
E K +W + R L+ ++
Sbjct: 290 ESVKE-QEWSMAVERGLHSKAK 310
>SYJ2_MOUSE (Q9D2G5) Synaptojanin 2 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 2)
Length = 1434
Score = 156 bits (394), Expect = 2e-37
Identities = 97/285 (34%), Positives = 142/285 (49%), Gaps = 43/285 (15%)
Query: 329 KSHPKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVF 388
+SH +Y+ + S Q+VG+ + ++V+ + + + V G+ G GNKG+V + +
Sbjct: 617 RSH-RYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQLH 675
Query: 389 QSRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDL 448
+ CFVCSHL +GQ E RN D EI + F S + I SHD +FW GD
Sbjct: 676 STSFCFVCSHLTAGQSQVKE--RNEDYREITHKLSFPS------GRNIFSHDYVFWCGDF 727
Query: 449 NYRINMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSD 508
NYRI+++ E+ V + W +LM+FDQL + G +F+ + EG +NF PTYKY+ S
Sbjct: 728 NYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGAVNFGPTYKYDVGSA 787
Query: 509 KHVGGNTQEGEKRRAPAWCDRILWLGK-------------------GIKQLK-------- 541
+ +K R PAW DR+LW K G Q++
Sbjct: 788 AY-----DTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDPQIRHTWSPGTL 842
Query: 542 --YQSAENQLSDHRPVSSIFLVDVEVIDHRKLERAIYFASAVVHP 584
Y AE Q SDHRPV +I V+V+ +D ER S+V P
Sbjct: 843 KYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGP 887
Score = 48.1 bits (113), Expect = 6e-05
Identities = 25/99 (25%), Positives = 50/99 (50%), Gaps = 18/99 (18%)
Query: 88 RAQYINTKEVRVTIGTWNVAG-----KHPCNDLEIEGWLCTEEE------------PSDI 130
++++ N K +++ +GTWNV G + E+ WL + P+D+
Sbjct: 521 QSEFTNFKRIQIAVGTWNVNGGKQFRSNLLGTAELTDWLLDAPQLSGAVDSQDDGSPADV 580
Query: 131 YIIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKS 169
+ IGF+E+V L+AGN+ A + W +++ +++S
Sbjct: 581 FAIGFEEMVELSAGNIVNASTTNR-KMWGEQLQKAISRS 618
>SYJ2_RAT (O55207) Synaptojanin 2 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 2)
Length = 1248
Score = 153 bits (387), Expect = 1e-36
Identities = 96/285 (33%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 329 KSHPKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVF 388
+SH +Y+ + S Q+VG+ + ++V+ + + + V G+ G GNKG+V +
Sbjct: 634 RSH-RYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFH 692
Query: 389 QSRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDL 448
+ CF+CSHL +GQ E RN D EI + F S + I SHD +FW GD
Sbjct: 693 STSFCFICSHLTAGQSQVKE--RNEDYREITHKLSFPS------GRNIFSHDYVFWCGDF 744
Query: 449 NYRINMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSD 508
NYRI+++ E+ V + W +LM+FDQL + G +F+ + EG INF PTYKY+ S
Sbjct: 745 NYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSA 804
Query: 509 KHVGGNTQEGEKRRAPAWCDRILWLGK-------------------GIKQLK-------- 541
+ +K R PAW DR+LW K G ++
Sbjct: 805 AY-----DTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTL 859
Query: 542 --YQSAENQLSDHRPVSSIFLVDVEVIDHRKLERAIYFASAVVHP 584
Y AE Q SDHRPV +I V+V+ +D ER S+V P
Sbjct: 860 KYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGP 904
Score = 47.4 bits (111), Expect = 1e-04
Identities = 25/99 (25%), Positives = 50/99 (50%), Gaps = 18/99 (18%)
Query: 88 RAQYINTKEVRVTIGTWNVAG-----KHPCNDLEIEGWLCTEEE------------PSDI 130
++++ N K +++ +GTWNV G + E+ WL + P+DI
Sbjct: 538 QSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPADI 597
Query: 131 YIIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKS 169
+ +GF+E+V L+AGN+ A + W +++ +++S
Sbjct: 598 FAVGFEEMVELSAGNIVNASTTNR-KMWGEQLQKAISRS 635
>SYJ1_HUMAN (O43426) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1575
Score = 153 bits (387), Expect = 1e-36
Identities = 92/270 (34%), Positives = 139/270 (51%), Gaps = 44/270 (16%)
Query: 333 KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRM 392
KYV + S+Q+VG+ + V+++ + + + V V G+ G GNKG+V++ M + +
Sbjct: 624 KYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSL 683
Query: 393 CFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI 452
CFVCSH A+GQ E RN D EI ++ F + + SHD +FW GD NYRI
Sbjct: 684 CFVCSHFAAGQSQVKE--RNEDFIEIARKLSFP------MGRMLFSHDYVFWCGDFNYRI 735
Query: 453 NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
++ + E+++L+ + W+ L+ DQL N+ G VF G+ EG + F PTYKY+ SD +
Sbjct: 736 DLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDY-- 793
Query: 513 GNTQEGEKRRAPAWCDRILW----------------LGKGIKQ-------------LKYQ 543
EK R PAW DR+LW L + L Y
Sbjct: 794 ---DTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYG 850
Query: 544 SAENQLSDHRPVSSIFLVDVEVIDHRKLER 573
AE + SDHRPV + L+D+++ + ER
Sbjct: 851 RAELKTSDHRPV--VALIDIDIFEVEAEER 878
Score = 50.1 bits (118), Expect = 2e-05
Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 19/100 (19%)
Query: 90 QYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTE------------------EEPSDIY 131
+Y K++RV +GTWNV G + + T+ +P+DI+
Sbjct: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585
Query: 132 IIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKSSE 171
IGF+E+V LNAGN+ A + W +++T+++ ++
Sbjct: 586 AIGFEEMVELNAGNIVSASTTNQ-KLWAVELQKTISRDNK 624
>SYJ1_BOVIN (O18964) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1) (p150)
(Fragment)
Length = 1324
Score = 152 bits (385), Expect = 2e-36
Identities = 91/270 (33%), Positives = 139/270 (50%), Gaps = 44/270 (16%)
Query: 333 KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRM 392
KYV + S+Q+VG+ + V+++ + + + V V G+ G GNKG+V++ M + +
Sbjct: 624 KYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSL 683
Query: 393 CFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI 452
CFVCSH A+GQ E RN D EI ++ F + + SHD +FW GD NYRI
Sbjct: 684 CFVCSHFAAGQSQVKE--RNDDFLEIARKLSFP------MGRLLFSHDYVFWCGDFNYRI 735
Query: 453 NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
++ + E+++L+ + W+ L+ DQL N+ G +F G+ EG + F PTYKY+ SD +
Sbjct: 736 DLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSDDY-- 793
Query: 513 GNTQEGEKRRAPAWCDRILW----------------LGKGIKQ-------------LKYQ 543
EK R PAW DR+LW L + L Y
Sbjct: 794 ---DTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYG 850
Query: 544 SAENQLSDHRPVSSIFLVDVEVIDHRKLER 573
AE + SDHRPV + L+D+++ + ER
Sbjct: 851 RAELKTSDHRPV--VALIDIDIFEVEAEER 878
Score = 50.1 bits (118), Expect = 2e-05
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 19/100 (19%)
Query: 90 QYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTE------------------EEPSDIY 131
+Y K++RV +GTWNV G + + T+ +P DI+
Sbjct: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPMDIF 585
Query: 132 IIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKSSE 171
IGF+E+V LNAGN+ A + W A +++T+++ ++
Sbjct: 586 PIGFEEMVELNAGNIVNASTTNQ-KLWAAELQKTISRDNK 624
>SYJ1_RAT (Q62910) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1574
Score = 151 bits (382), Expect = 4e-36
Identities = 90/270 (33%), Positives = 139/270 (51%), Gaps = 44/270 (16%)
Query: 333 KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRM 392
KYV + S+Q+VG+ + V+++ + + + V V G+ G GNKG+V++ M + +
Sbjct: 624 KYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSL 683
Query: 393 CFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI 452
CFVCSH A+GQ E RN D EI ++ F + + SHD +FW GD NYRI
Sbjct: 684 CFVCSHFAAGQSQVKE--RNEDFVEIARKLSFP------MGRMLFSHDYVFWCGDFNYRI 735
Query: 453 NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
++ + E+++L+ + W+ L+ DQL N+ G +F G+ EG + F PTYKY+ S+ +
Sbjct: 736 DLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDY-- 793
Query: 513 GNTQEGEKRRAPAWCDRILW----------------LGKGIKQ-------------LKYQ 543
EK R PAW DR+LW L + L Y
Sbjct: 794 ---DTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYG 850
Query: 544 SAENQLSDHRPVSSIFLVDVEVIDHRKLER 573
AE + SDHRPV + L+D+++ + ER
Sbjct: 851 RAELKTSDHRPV--VALIDIDIFEVEAEER 878
Score = 50.1 bits (118), Expect = 2e-05
Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 19/100 (19%)
Query: 90 QYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTE------------------EEPSDIY 131
+Y K++RV +GTWNV G + + T+ +P+DI+
Sbjct: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585
Query: 132 IIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKSSE 171
IGF+E+V LNAGN+ A + W +++T+++ ++
Sbjct: 586 AIGFEEMVELNAGNIVNASTTNQ-KLWAVELQKTISRDNK 624
>SYJ1_MOUSE (Q8CHC4) Synaptojanin 1 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1574
Score = 151 bits (382), Expect = 4e-36
Identities = 90/270 (33%), Positives = 139/270 (51%), Gaps = 44/270 (16%)
Query: 333 KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRM 392
KYV + S+Q+VG+ + V+++ + + + V V G+ G GNKG+V++ M + +
Sbjct: 624 KYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSL 683
Query: 393 CFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI 452
CFVCSH A+GQ E RN D EI ++ F + + SHD +FW GD NYRI
Sbjct: 684 CFVCSHFAAGQSQVKE--RNEDFVEIARKLSFP------MGRMLFSHDYVFWCGDFNYRI 735
Query: 453 NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
++ + E+++L+ + W+ L+ DQL N+ G +F G+ EG + F PTYKY+ S+ +
Sbjct: 736 DLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDY-- 793
Query: 513 GNTQEGEKRRAPAWCDRILW----------------LGKGIKQ-------------LKYQ 543
EK R PAW DR+LW L + L Y
Sbjct: 794 ---DTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYG 850
Query: 544 SAENQLSDHRPVSSIFLVDVEVIDHRKLER 573
AE + SDHRPV + L+D+++ + ER
Sbjct: 851 RAELKTSDHRPV--VALIDIDIFEVEAEER 878
Score = 50.1 bits (118), Expect = 2e-05
Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 19/100 (19%)
Query: 90 QYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTE------------------EEPSDIY 131
+Y K++RV +GTWNV G + + T+ +P+DI+
Sbjct: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585
Query: 132 IIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKSSE 171
IGF+E+V LNAGN+ A + W +++T+++ ++
Sbjct: 586 AIGFEEMVELNAGNIVNASTTNQ-KLWAVELQKTISRDNK 624
>YIA2_YEAST (P40559) Hypothetical 108.4 kDa protein in BET1-PAN1
intergenic region
Length = 946
Score = 149 bits (377), Expect = 2e-35
Identities = 91/239 (38%), Positives = 134/239 (55%), Gaps = 14/239 (5%)
Query: 333 KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRM 392
KY+R+ S Q+ GI + +++ V H++ G G NKG+V+VS +R
Sbjct: 606 KYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRF 665
Query: 393 CFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI 452
C + SHLA+G ++ EQR N D I + RFS +I HD I W GD NYRI
Sbjct: 666 CVLVSHLAAGLEN-VEQRHN-DYKTIAKSIRFSKGL------RIKDHDAIIWMGDFNYRI 717
Query: 453 NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
MS+ ++R+ + K++ L + DQL+ ++ G F + E I+FPPTYK++ +
Sbjct: 718 LMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTK---- 773
Query: 513 GNTQEGEKRRAPAWCDRILWLGKGIKQLKYQSAENQL-SDHRPVSSIFLVDVEVIDHRK 570
N EK R PAW DRIL G+ ++QL+Y+ E+ L SDHRPV +IF V V+D +K
Sbjct: 774 -NYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQK 831
Score = 54.3 bits (129), Expect = 9e-07
Identities = 35/96 (36%), Positives = 54/96 (55%), Gaps = 11/96 (11%)
Query: 87 LRAQYINTKEVRVTIGTWNVAGKHPCNDLEIEGWL-----CTEEEPSDIYIIGFQEVVPL 141
LR++Y K++ + GT+N++GK P +D I+ W+ E+E +D+Y+IG +EVV L
Sbjct: 517 LRSKYTFEKDISIFAGTFNISGKIPKDD--IKDWIFPKSMSKEDEMADLYVIGLEEVVEL 574
Query: 142 NAGNVFGAEDSKPIPKWDALIRRTLNKSSEPGTKKK 177
G++ A D W+ I LN PG KKK
Sbjct: 575 TPGHML-ATDPYVRQFWEKKILTLLN---GPGRKKK 606
>SYJ2_HUMAN (O15056) Synaptojanin 2 (EC 3.1.3.36) (Synaptic
inositol-1,4,5-trisphosphate 5-phosphatase 2) (Fragment)
Length = 1443
Score = 149 bits (375), Expect = 3e-35
Identities = 94/286 (32%), Positives = 138/286 (47%), Gaps = 45/286 (15%)
Query: 329 KSHPKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVF 388
+SH +Y+ + S Q+VG+ + ++V+ + + + V G+ G GNKG+V +
Sbjct: 564 RSH-RYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFH 622
Query: 389 QSRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDL 448
+ CF+CSHL +GQ E RN D EI Q+ F + + SHD +FW GD
Sbjct: 623 STSFCFICSHLTAGQSQVKE--RNEDYKEITQKLCFP------MGRNVFSHDYVFWCGDF 674
Query: 449 NYRINMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSD 508
NYRI+++ E+ V + W +L++FDQL + G +F+ + EG INF PTYKY+ S
Sbjct: 675 NYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSA 734
Query: 509 KHVGGNTQEGEKRRAPAWCDRILWLGK------------------------------GIK 538
+ +K R PAW DR+LW K G
Sbjct: 735 AY-----DTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGAL 789
Query: 539 QLKYQSAENQLSDHRPVSSIFLVDVEVIDHRKLERAIYFASAVVHP 584
Q Y AE Q SDHRPV +I V+V+ +D ER S+ P
Sbjct: 790 QY-YGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGP 834
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 18/99 (18%)
Query: 88 RAQYINTKEVRVTIGTWNVAG-----KHPCNDLEIEGWLCT------------EEEPSDI 130
++++ N K +R+ +GTWNV G + E+ WL + P+DI
Sbjct: 468 QSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADI 527
Query: 131 YIIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKS 169
+ +GF+E+V L+AGN+ A + W +++ +++S
Sbjct: 528 FAVGFEEMVELSAGNIVNASTTNK-KMWGEQLQKAISRS 565
>YNK6_YEAST (P50942) Hypothetical 133.3 kDa protein in CYB5-LEU4
intergenic region
Length = 1183
Score = 147 bits (372), Expect = 6e-35
Identities = 82/259 (31%), Positives = 144/259 (54%), Gaps = 19/259 (7%)
Query: 333 KYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRM 392
KY+ + +QM + + + + ++ + S G G GNKG+V++ +
Sbjct: 665 KYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSF 724
Query: 393 CFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI 452
CFV +HL++G + ++RRN D + I + F + + IP HD +FW GDLNYRI
Sbjct: 725 CFVNTHLSAGASN-IDERRN-DYNNIYRNITFP------RSKTIPHHDSLFWLGDLNYRI 776
Query: 453 NMSDGEIRKLVDLKK---WNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDK 509
+++ E+R+ + +K + L+++DQL+ E+ +G VF+G+KE + F PTYKY++ +D
Sbjct: 777 TLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTD- 835
Query: 510 HVGGNTQEGEKRRAPAWCDRILWLGKGIKQLKYQSAENQLSDHRPVSSIFLVDVEVIDHR 569
N EK R P+W DRI++ G+ + L Y A ++SDH+PV + + +V+ +D +
Sbjct: 836 ----NYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEK 891
Query: 570 K---LERAIYFASAVVHPD 585
+ L +Y HP+
Sbjct: 892 EKLNLVEKLYAEYKNTHPE 910
Score = 39.3 bits (90), Expect = 0.030
Identities = 21/82 (25%), Positives = 42/82 (50%), Gaps = 1/82 (1%)
Query: 90 QYINTKEVRVTIGTWNVAGKHPCNDLEIEGWLCTEEEPSDIYIIGFQEVVPLNAGNVFGA 149
++ + + +GT+NV G DL + ++ D+ ++G QEV+ L AG++ A
Sbjct: 584 KFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDVVVLGLQEVIELTAGSILNA 643
Query: 150 EDSKPIPKWDALIRRTLNKSSE 171
+ +K W+ ++ LN+ E
Sbjct: 644 DYTKS-SFWETMVTDCLNQYEE 664
>SYJ1_SCHPO (O43001) Synaptojanin homolog 1 (EC 3.1.3.36)
(Inositol-1,4,5-trisphosphate 5-phosphatase 1)
Length = 1076
Score = 134 bits (338), Expect = 5e-31
Identities = 78/241 (32%), Positives = 129/241 (53%), Gaps = 14/241 (5%)
Query: 330 SHPKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQ 389
S P YV++ S Q+VG + ++ + + +++ + GL G GNKG+V++
Sbjct: 631 SGPGYVQLRSGQLVGTALMIFCKESCLPSIKNVEGTVKKTGLGGVSGNKGAVAIRFDYED 690
Query: 390 SRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLN 449
+ +CF+ SHLA+G + E R+ D I RF + + I +HD + WFGD N
Sbjct: 691 TGLCFITSHLAAGYTNYDE--RDHDYRTIASGLRFR------RGRSIFNHDYVVWFGDFN 742
Query: 450 YRINMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDK 509
YRI+++ E+ + K + L ++DQL+ ++ G VF + E I FPPTYK++ +D
Sbjct: 743 YRISLTYEEVVPCIAQGKLSYLFEYDQLNKQMLTGKVFPFFSELPITFPPTYKFDIGTDI 802
Query: 510 HVGGNTQEGEKRRAPAWCDRILWLGKGIKQLKYQSAENQLSDHRPVSSIFLVDVEVIDHR 569
+ +K R PAW DRIL+ G+ + YQS SDHRP+ + + ++ +D
Sbjct: 803 Y-----DTSDKHRVPAWTDRILYRGELVPH-SYQSVPLYYSDHRPIYATYEANIVKVDRE 856
Query: 570 K 570
K
Sbjct: 857 K 857
Score = 53.5 bits (127), Expect = 2e-06
Identities = 32/102 (31%), Positives = 55/102 (53%), Gaps = 9/102 (8%)
Query: 74 YEMKRHRRRKSETLRAQYINTKEVRVTIGTWNVAGKHPCN-DLEIEGWLCTEEEP-SDIY 131
+E H RK E ++ K V++ + ++N+ G C+ ++E WL E P +DIY
Sbjct: 538 HEYVNHELRKREN---EFSEHKNVKIFVASYNLNG---CSATTKLENWLFPENTPLADIY 591
Query: 132 IIGFQEVVPLNAGNVFGAEDSKPIPKWDALIRRTLNKSSEPG 173
++GFQE+V L V A+ +K +W++ ++R LN G
Sbjct: 592 VVGFQEIVQLTPQQVISADPAKR-REWESCVKRLLNGKCTSG 632
>P5PA_HUMAN (Q15735) Phosphatidylinositol 4,5-bisphosphate
5-phosphatase A (EC 3.1.3.56)
Length = 1006
Score = 116 bits (291), Expect = 1e-25
Identities = 80/258 (31%), Positives = 127/258 (49%), Gaps = 29/258 (11%)
Query: 334 YVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRMC 393
+V + S +M G+ + ++ + + ++ GL GY GNKG VSV ++ F +C
Sbjct: 496 FVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLC 555
Query: 394 FVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRIN 453
F+ HL + D AEQR+++ Q F Q I H+ +FWFGDLN+RI
Sbjct: 556 FLNCHLPA-HMDKAEQRKDN-----FQTILSLQQFQGPGAQGILDHELVFWFGDLNFRIE 609
Query: 454 MSDGEIRKL-VDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
D K +D + ++L + DQL+ + +G++EG +NF PT+K++ ++K+
Sbjct: 610 SYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKY-- 667
Query: 513 GNTQEGEKRRAPAWCDRILWLGKG----------------IKQLKYQS-AENQLSDHRPV 555
K+R PAW DRILW K + Q Y+S E +SDH+PV
Sbjct: 668 ---DTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPV 724
Query: 556 SSIFLVDVEVIDHRKLER 573
++ FL+ D L R
Sbjct: 725 AAQFLLQFAFRDDMPLVR 742
>P5PA_RAT (Q9JMC1) Phosphatidylinositol 4,5-bisphosphate
5-phosphatase A (EC 3.1.3.56) (Proline-rich inositol
polyphosphate 5-phosphatase)
Length = 1001
Score = 114 bits (286), Expect = 6e-25
Identities = 79/258 (30%), Positives = 126/258 (48%), Gaps = 29/258 (11%)
Query: 334 YVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRMC 393
+V + + +M G+ + ++ + + ++ GL GY GNKG VSV ++ F +C
Sbjct: 491 FVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLC 550
Query: 394 FVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRIN 453
F+ HL + D AEQR+++ Q F I HD +FWFGDLN+RI
Sbjct: 551 FLNCHLPA-HMDKAEQRKDN-----FQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIE 604
Query: 454 MSDGEIRKL-VDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
D K +D + ++L + DQL+ + +G++EG +NF PT+K++ ++K+
Sbjct: 605 SYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKY-- 662
Query: 513 GNTQEGEKRRAPAWCDRILWLGKG----------------IKQLKYQS-AENQLSDHRPV 555
K+R PAW DRILW K + Q Y+S E +SDH+PV
Sbjct: 663 ---DTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPV 719
Query: 556 SSIFLVDVEVIDHRKLER 573
++ FL+ D L R
Sbjct: 720 AARFLLQFAFRDDVPLVR 737
>P5PA_MOUSE (P59644) Phosphatidylinositol 4,5-bisphosphate
5-phosphatase A (EC 3.1.3.56)
Length = 1003
Score = 114 bits (284), Expect = 9e-25
Identities = 78/258 (30%), Positives = 126/258 (48%), Gaps = 29/258 (11%)
Query: 334 YVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRMC 393
+V + + +M G+ + ++ + + ++ GL GY GNKG VSV ++ F +C
Sbjct: 493 FVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLC 552
Query: 394 FVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRIN 453
F+ HL + D AEQR+++ Q F I HD +FWFGDLN+RI
Sbjct: 553 FLNCHLPA-HMDKAEQRKDN-----FQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIE 606
Query: 454 MSDGEIRKL-VDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
D K +D + ++L + DQL+ + +G++EG +NF PT+K++ ++K+
Sbjct: 607 SYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKY-- 664
Query: 513 GNTQEGEKRRAPAWCDRILWLGKG----------------IKQLKYQS-AENQLSDHRPV 555
K+R PAW DRILW K + Q Y+S E +SDH+PV
Sbjct: 665 ---DTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPV 721
Query: 556 SSIFLVDVEVIDHRKLER 573
++ F++ D L R
Sbjct: 722 AAQFILQFAFRDDVPLVR 739
>INP5_RAT (Q9WVR1) 72 kDa inositol polyphosphate 5-phosphatase (EC
3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate
5-phosphatase) (Phosphatidylinositol polyphosphate
5-phosphatase type IV) (5-phosphatase that induces
arborization) (Pharbin)
Length = 647
Score = 108 bits (269), Expect = 5e-23
Identities = 74/247 (29%), Positives = 124/247 (49%), Gaps = 24/247 (9%)
Query: 332 PKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSR 391
P+YV + S +Y+S++++R L ++ S V ++ + KG++ VS + F +
Sbjct: 361 PQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTS 420
Query: 392 MCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPS------HDKIFWF 445
F+ SH SG DG R D + +Q P + + D++FWF
Sbjct: 421 FLFITSHFTSG--DGKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWF 478
Query: 446 GDLNYRINMSDGEIRKLVDLKKWNE-----LMKFDQLSNELCKGHVFEGWKEGLINFPPT 500
GD N+R+ S G + LK+ E L++ DQL+ E+ KG +F+G++E I+F P+
Sbjct: 479 GDFNFRL--SGGRVAVEAFLKQDPEVDVLALLQHDQLTREMKKGSIFKGFEEAEIHFLPS 536
Query: 501 YKYEFNSDKHVGGNTQEGEKRRAPAWCDRILWLGK---GIKQLKYQSAEN-QLSDHRPVS 556
YK++ D + K+R P++ DR+L+ + I +KY S + SDHRPV
Sbjct: 537 YKFDIGKDTY-----DSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVY 591
Query: 557 SIFLVDV 563
+F V V
Sbjct: 592 GLFRVKV 598
>INP5_MOUSE (Q9JII1) 72 kDa inositol polyphosphate 5-phosphatase (EC
3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate
5-phosphatase) (Phosphatidylinositol polyphosphate
5-phosphatase type IV)
Length = 647
Score = 108 bits (269), Expect = 5e-23
Identities = 92/347 (26%), Positives = 157/347 (44%), Gaps = 34/347 (9%)
Query: 240 LDPIHHVDSSPKMRRVQSTSDSASLYGFEMKSLHQSSGNFSLL---WSEKQQEIVPQVFD 296
L PI D + S S +L G E + + N +L W+ + Q+ +P D
Sbjct: 263 LAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLD 322
Query: 297 SHLDVSDMLSDEDNDTF-----SELANNEDANGIISVKSHPKYVRIVSKQMVGIYVSVWV 351
L ++ +D D + ++ + + P+YV + S +Y+S+++
Sbjct: 323 EFLLPTE--ADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFI 380
Query: 352 QRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRMCFVCSHLASGQKDGAEQRR 411
+R L ++ S V ++ + KG++ VS + F + F+ SH SG DG R
Sbjct: 381 RRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSG--DGKVAER 438
Query: 412 NSDVHEILQRTRFSSVFDTDQPQKIPS------HDKIFWFGDLNYRINMSDGEIRKLVDL 465
D +Q P + + D++FWFGD N+R+ S G + L
Sbjct: 439 LLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRL--SGGRVAVEAFL 496
Query: 466 KKWNE-----LMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVGGNTQEGEK 520
K+ E L++ DQL+ E+ KG +F G++E I+F P+YK++ D + K
Sbjct: 497 KQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTY-----DSTSK 551
Query: 521 RRAPAWCDRILWLGK---GIKQLKYQSAEN-QLSDHRPVSSIFLVDV 563
+R P++ DR+L+ + I +KY S + SDHRPV +F V V
Sbjct: 552 QRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKV 598
>INP5_HUMAN (Q9NRR6) 72 kDa inositol polyphosphate 5-phosphatase (EC
3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate
5-phosphatase) (Phosphatidylinositol polyphosphate
5-phosphatase type IV)
Length = 644
Score = 96.7 bits (239), Expect = 2e-19
Identities = 70/248 (28%), Positives = 119/248 (47%), Gaps = 26/248 (10%)
Query: 332 PKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSR 391
P YV + S +Y+S++++R L ++ S V ++ + KG++ +S + F +
Sbjct: 358 PHYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTS 417
Query: 392 MCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPS------HDKIFWF 445
F+ SH SG DG R D +Q P + + D++FWF
Sbjct: 418 FLFITSHFTSG--DGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWF 475
Query: 446 GDLNYRINMSDGEIRKL------VDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPP 499
GD N+R++ + L VD+ L++ DQL E+ KG +F+G++E I+F P
Sbjct: 476 GDFNFRLSGGRTVVDALLCQGLVVDVP---ALLQHDQLIREMRKGSIFKGFQEPDIHFLP 532
Query: 500 TYKYEFNSDKHVGGNTQEGEKRRAPAWCDRILWLGK---GIKQLKYQSAEN-QLSDHRPV 555
+YK++ D + K+R P++ DR+L+ + I + Y S + SDHRPV
Sbjct: 533 SYKFDIGKDTY-----DSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSDHRPV 587
Query: 556 SSIFLVDV 563
+F V V
Sbjct: 588 YGLFRVKV 595
>SKIP_MOUSE (Q8C5L6) Skeletal muscle and kidney enriched inositol
phosphatase (EC 3.1.3.56)
Length = 468
Score = 95.9 bits (237), Expect = 3e-19
Identities = 69/237 (29%), Positives = 111/237 (46%), Gaps = 19/237 (8%)
Query: 334 YVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGNKGSVSVSMSVFQSRMC 393
+V+I +M G+ + V+ + + ++ + GL GY GNKG V+V + ++ +
Sbjct: 103 FVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYYVS 162
Query: 394 FVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIPSHDKIFWFGDLNYRI- 452
+ HL + ++ + D R S F+ I HD I WFGD+N+RI
Sbjct: 163 IINCHLPPHMYNNDQRLEHFD------RILESLTFEGYDVPNILDHDLILWFGDMNFRIE 216
Query: 453 NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLINFPPTYKYEFNSDKHVG 512
+ +++ + K + EL + DQL + ++EG + FPPTYK+ D+H
Sbjct: 217 DFGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKF----DRH-S 271
Query: 513 GNTQEGEKRRAPAWCDRILWLGKGIKQLKYQ-SAENQLSDHRPVSSIFLVDVEVIDH 568
N EK+R PAW DRILW +LK Q S + L+ P S L + H
Sbjct: 272 NNYDTSEKKRKPAWTDRILW------RLKRQPSQASPLASSVPTSYFLLTLKNYVSH 322
Score = 33.1 bits (74), Expect = 2.1
Identities = 24/69 (34%), Positives = 32/69 (45%), Gaps = 3/69 (4%)
Query: 99 VTIGTWNVAGKHPCNDLEIEGWLCTEEEPSDIYIIGFQEVVPLNAGNVFGAEDSKPIPKW 158
V + TWNVA P DL L ++ DIYIIG QE +N G + D+ W
Sbjct: 34 VHVVTWNVASAAPTVDLSDLLQLNNQDLNLDIYIIGLQE---MNFGIISLLSDAAFEDPW 90
Query: 159 DALIRRTLN 167
+L L+
Sbjct: 91 SSLFMDMLS 99
>SKIP_HUMAN (Q9BT40) Skeletal muscle and kidney enriched inositol
phosphatase (EC 3.1.3.56)
Length = 448
Score = 95.1 bits (235), Expect = 5e-19
Identities = 72/266 (27%), Positives = 126/266 (47%), Gaps = 30/266 (11%)
Query: 318 NNEDANGIISVKSHPKYVRIVSKQMVGIYVSVWVQRKLRRHVHHLKVSQVGVGLMGYMGN 377
N+ ++ ++ V S ++++ +M GI + V+ + + ++ L GL GY GN
Sbjct: 69 NDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGN 128
Query: 378 KGSVSVSMSVFQSRMCFVCSHLASGQKDGAEQRRNSDVHEILQRTRFSSVFDTDQPQKIP 437
KG V++ + ++ + + HL + ++ + D IL+ + D P I
Sbjct: 129 KGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFD--RILE---MQNCEGRDIP-NIL 182
Query: 438 SHDKIFWFGDLNYRI-NMSDGEIRKLVDLKKWNELMKFDQLSNELCKGHVFEGWKEGLIN 496
HD I WFGD+N+RI + +R+ + + + L + DQLS + ++EG +
Sbjct: 183 DHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLL 242
Query: 497 FPPTYKYEFNSDKHVGGNTQEGEKRRAPAWCDRILWLGK-----------------GIKQ 539
FPPTYK++ NS+ + EK+R PAW DRILW K +
Sbjct: 243 FPPTYKFDRNSNDY-----DTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSL 297
Query: 540 LKYQSAENQ-LSDHRPVSSIFLVDVE 564
Y S +SDH+PVS F ++++
Sbjct: 298 RGYSSHMTYGISDHKPVSGTFDLELK 323
Score = 33.1 bits (74), Expect = 2.1
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 3/76 (3%)
Query: 95 KEVRVTIGTWNVAGKHPCNDLEIEGWLCTEEEPSDIYIIGFQEVVPLNAGNVFGAEDSKP 154
+ + + + TWNVA P DL L DIY+IG QE LN+G + D+
Sbjct: 12 RRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQE---LNSGIISLLSDAAF 68
Query: 155 IPKWDALIRRTLNKSS 170
W + + L+ S
Sbjct: 69 NDSWSSFLMDVLSPLS 84
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.315 0.132 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,729,747
Number of Sequences: 164201
Number of extensions: 3186306
Number of successful extensions: 8996
Number of sequences better than 10.0: 46
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 8854
Number of HSP's gapped (non-prelim): 91
length of query: 599
length of database: 59,974,054
effective HSP length: 116
effective length of query: 483
effective length of database: 40,926,738
effective search space: 19767614454
effective search space used: 19767614454
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Medicago: description of AC147404.2