BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC147363.5 - phase: 0 
         (433 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

HMGL_CHICK (P35915) Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)...   398  e-110
HMGL_RAT (P97519) Hydroxymethylglutaryl-CoA lyase, mitochondrial...   395  e-109
HMGL_MOUSE (P38060) Hydroxymethylglutaryl-CoA lyase, mitochondri...   389  e-107
HMGL_HUMAN (P35914) Hydroxymethylglutaryl-CoA lyase, mitochondri...   387  e-107
HMGL_PSEMV (P13703) Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)...   309  1e-83
HMGL_BOVIN (Q29448) Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)...   175  2e-43
LEU1_PYRAE (Q8ZW35) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    72  4e-12
LE11_METMA (P58967) 2-isopropylmalate synthase 1 (EC 2.3.3.13) (...    69  2e-11
LEU1_YERPE (Q8ZIG8) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    66  2e-10
LEU1_BACSU (P94565) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    66  2e-10
LE12_METKA (Q8TYM1) 2-isopropylmalate synthase 2 (EC 2.3.3.13) (...    66  2e-10
LEU1_VIBCH (Q9KP83) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    66  2e-10
LEU1_VIBVY (Q7MP77) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    65  3e-10
LEU1_VIBVU (Q8DEE1) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    65  3e-10
LEU1_DEIRA (Q9RUA9) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    65  4e-10
CIMA_METKA (Q8TYB1) (R)-citramalate synthase (EC 2.3.3.-)              65  4e-10
LEU1_GLOVI (Q7NI93) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    64  6e-10
LEU1_PHOLL (Q7N129) 2-isopropylmalate synthase (EC 2.3.3.13) (Al...    64  8e-10
LE11_SULTO (Q974X3) 2-isopropylmalate synthase 1 (EC 2.3.3.13) (...    64  1e-09
LE11_METKA (Q8TW28) 2-isopropylmalate synthase 1 (EC 2.3.3.13) (...    64  1e-09

>HMGL_CHICK (P35915) Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
           (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA
           lyase)
          Length = 298

 Score =  398 bits (1023), Expect = e-110
 Identities = 199/296 (67%), Positives = 237/296 (79%)

Query: 131 PEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAK 190
           P+ VK+VEVGPRDGLQNEK++VPT VKI LI  L+ TGL VIEATSFVSP+WVPQ+AD  
Sbjct: 3   PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 62

Query: 191 DVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSR 250
           +VMQ ++ L G+  PVLTPNLKGF+AAVAAGA+EV++F +ASE F+K NINCSIEESL R
Sbjct: 63  EVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLER 122

Query: 251 YRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVG 310
           +  V  AA+  SIPVRGYVSCV+GCP EG +  +KVA V+K +Y MGC+EISLGD IG+G
Sbjct: 123 FSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGIG 182

Query: 311 TPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYA 370
           TPG++  ML AVM  VP   LAVH HDTYGQ+L NILV+LQMG+S VD+SVAGLGGCPYA
Sbjct: 183 TPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPYA 242

Query: 371 KGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIALNRV 426
           +GASGNVATED+VYMLNGLGI T VD+ KLM  G FI   L R + SK + A  R+
Sbjct: 243 QGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298


>HMGL_RAT (P97519) Hydroxymethylglutaryl-CoA lyase, mitochondrial
           precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL)
           (3-hydroxy-3-methylglutarate-CoA lyase)
          Length = 325

 Score =  395 bits (1014), Expect = e-109
 Identities = 199/296 (67%), Positives = 234/296 (78%)

Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
           M  +P+ VKIVEVGPRDGLQNEK+IVPT VKI+LI  L+  GL VIEATSFVSPKWVPQ+
Sbjct: 26  MGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLIDMLSEAGLPVIEATSFVSPKWVPQM 85

Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
           AD  DV++ +    GI  PVLTPN+KGFE AVAAGA+EV++F +ASE F++ N+NCSIEE
Sbjct: 86  ADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSIFGAASELFTRKNVNCSIEE 145

Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
           S  R+  V +AA+  SI VRGYVSC +GCP EG V P+KVA VAK LY MGC+EISLGDT
Sbjct: 146 SFQRFDGVMQAARAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDT 205

Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
           IGVGTPG +  ML AV+  VP   LAVH HDTYGQ+L N LV+LQMG+S VDSSVAGLGG
Sbjct: 206 IGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGG 265

Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
           CPYAKGASGN+ATED+VYML GLGI T V++ KL+ AGDFI + L R + SK A A
Sbjct: 266 CPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321


>HMGL_MOUSE (P38060) Hydroxymethylglutaryl-CoA lyase, mitochondrial
           precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL)
           (3-hydroxy-3-methylglutarate-CoA lyase)
          Length = 325

 Score =  389 bits (998), Expect = e-107
 Identities = 198/296 (66%), Positives = 229/296 (76%)

Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
           M  +P+ VKIVEVGPRDGLQNEK+IVPT VKI LI  L+  GL VIEATSFVSP WVPQ+
Sbjct: 26  MGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPNWVPQM 85

Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
           AD  DV++ +    GI  PVLTPN+KGFE AVAAGA+EV+VF + SE F++ N NCSIEE
Sbjct: 86  ADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEE 145

Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
           S  R+  V +AA+  SI VRGYVSC +GCP EG V P+KVA VAK LY MGC+EISLGDT
Sbjct: 146 SFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDT 205

Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
           IGVGTPG +  ML AVM  VP   L VH HDT GQ+L N LV+LQMG+S VDSSVAGLGG
Sbjct: 206 IGVGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQALANTLVALQMGVSVVDSSVAGLGG 265

Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
           CPYAKGASGN+ATED+VYMLNGLGI T V++ KL+ AGDFI + L R + SK A A
Sbjct: 266 CPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321


>HMGL_HUMAN (P35914) Hydroxymethylglutaryl-CoA lyase, mitochondrial
           precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL)
           (3-hydroxy-3-methylglutarate-CoA lyase)
          Length = 325

 Score =  387 bits (995), Expect = e-107
 Identities = 195/296 (65%), Positives = 231/296 (77%)

Query: 127 MKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
           M  +P+ VKIVEVGPRDGLQNEKNIV T VKI+LI  L+  GLSVIE TSFVSPKWVPQ+
Sbjct: 26  MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85

Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
            D  +V++ +    GI  PVLTPNLKGFEAAVAAGA+EV +F +ASE F+K NINCSIEE
Sbjct: 86  GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145

Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDT 306
           S  R+ A+ +AA+  +I VRGYVSC +GCP EG + P+KVA V K  Y MGC+EISLGDT
Sbjct: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205

Query: 307 IGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
           IGVGTPG +  ML AVM  VP   LAVH HDTYGQ+L N L++LQMG+S VDSSVAGLGG
Sbjct: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265

Query: 367 CPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
           CPYA+GASGN+ATED+VYML GLGI T V++ KL+ AG+FI + L R + SK A A
Sbjct: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321


>HMGL_PSEMV (P13703) Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
           (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA
           lyase)
          Length = 301

 Score =  309 bits (791), Expect = 1e-83
 Identities = 155/290 (53%), Positives = 200/290 (68%)

Query: 134 VKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAKDVM 193
           VK+ EVGPRDGLQNE+  +    ++ LI  LA TGL  IEA +FVSP+WVPQ+A + +V+
Sbjct: 4   VKVFEVGPRDGLQNERQPLSVAARVGLIGELAGTGLRHIEAGAFVSPRWVPQMAGSDEVL 63

Query: 194 QAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSRYRA 253
           + + +  G+    L PN +GFEAA  AG REVAVFA+ASE+FS++NINCSI+ES  R+  
Sbjct: 64  RQLPSNDGVSYTALVPNRQGFEAAQRAGCREVAVFAAASEAFSRNNINCSIDESFERFTP 123

Query: 254 VTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVGTPG 313
           V RAA E SI VRGYVSCV+GCP  G V P  VA VA+ LY++GC+EISLGDTIG G P 
Sbjct: 124 VLRAANEASIRVRGYVSCVLGCPFSGAVAPEAVAKVARRLYELGCYEISLGDTIGAGRPD 183

Query: 314 TVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYAKGA 373
               +       +P   LA HFHDT+G ++ N+  +L  G+   DSSVAGLGGCPY+ GA
Sbjct: 184 ETAQLFELCARQLPVAALAGHFHDTWGMAIANVHAALAQGVRTFDSSVAGLGGCPYSPGA 243

Query: 374 SGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIAL 423
           SGNVATED++Y+L+GLG  T VD+  +   G  I  QLG  + S+  +AL
Sbjct: 244 SGNVATEDLLYLLHGLGYSTGVDLEAVAQVGVRISAQLGTANRSRAGLAL 293


>HMGL_BOVIN (Q29448) Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
           (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA
           lyase) (Fragment)
          Length = 140

 Score =  175 bits (444), Expect = 2e-43
 Identities = 89/136 (65%), Positives = 104/136 (76%)

Query: 287 AYVAKALYDMGCFEISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNI 346
           A V K LY MGC+EISLGDTIGVGTPG +  ML A +  VP   LAVH HDTYGQ+L N 
Sbjct: 1   AEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAALQEVPVTALAVHCHDTYGQALANT 60

Query: 347 LVSLQMGISAVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDF 406
           L +LQMG+S +DSSVAGLGGCPYA+GASGN+ATED+VYML GLGI T V++ KL+ AG F
Sbjct: 61  LTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLLEAGAF 120

Query: 407 IGKQLGRPSGSKTAIA 422
           I + L R + SK A A
Sbjct: 121 ICQALNRRTNSKVAQA 136


>LEU1_PYRAE (Q8ZW35) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 364

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 65/266 (24%), Positives = 116/266 (43%), Gaps = 17/266 (6%)

Query: 157 KIELIHRLASTGLSVIEATSFVSPKWVPQLADAKDVMQAVHNLRGIRLPVLTPNLKGFEA 216
           K+E+   L   G+ +IEA  F +     + A  K + + V   + + L  +T +    +A
Sbjct: 11  KLEIAMALDDAGVDMIEA-GFAAVSDDEKEA-IKLISKEVSRAKVVSLARMTKS--DVDA 66

Query: 217 AVAAGAREVAVFASASESFSKSNINCSIEESLSRYRAVTRAAKELSIPVRGYVSCVVGCP 276
           A  A    + +F + S+   K  +  + EE+L R   V   AK   + +           
Sbjct: 67  AAEADVDMIHLFIATSDIHLKYKLGITREEALRRIEEVVSYAKSYGVEILFSAEDATRSD 126

Query: 277 VEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFH 336
           +E       +A   K   + G  EI++ DT+GV TP  +  ++  +   +P   + VH H
Sbjct: 127 LEF------LAKAYKTAIEAGADEINVPDTVGVMTPSRMAYLIKYLRERLPPIPMHVHCH 180

Query: 337 DTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYAKGASGNVATEDVVYMLNG-LGIKTNV 395
           D +G ++ N + +++ G       V   G        +GN A E+VV  ++  LG++TN+
Sbjct: 181 DDFGMAVANTVTAIENGADVAQVVVNNFG------ERAGNAALEEVVAAVHYLLGLRTNI 234

Query: 396 DIGKLMSAGDFIGKQLGRPSGSKTAI 421
            + KL S    + K  G P     A+
Sbjct: 235 KLEKLYSLSQLVSKLFGVPVPPNKAV 260


>LE11_METMA (P58967) 2-isopropylmalate synthase 1 (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase 1) (Alpha-IPM synthetase
           1)
          Length = 405

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 77/309 (24%), Positives = 132/309 (41%), Gaps = 23/309 (7%)

Query: 126 FMKGMPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQ 185
           F+   P  ++I +V  RDG Q    +   + K+ +   L S G+ VIEA   V       
Sbjct: 15  FIDYRPLDIEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVS----- 69

Query: 186 LADAKDVMQAVHNLR-GIRLPVLTPNLKG-FEAAVAAGAREVAVFASASESFSKSNINCS 243
            AD K++++ + N     R+  L+  +KG  +AA+      V++F + S+   K   + S
Sbjct: 70  -ADEKEIVKEIANQGFNSRICCLSRAVKGDVDAALECDVDIVSIFIAMSDMHLKYKYHRS 128

Query: 244 IEESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSK-VAYVAKALYDMGCFEIS 302
           +E+ L   +     A +  + VR         PVE      K V    K  Y      +S
Sbjct: 129 LEDMLGCAKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQY------VS 182

Query: 303 LGDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVA 362
           L DT+G+  P T   ++  +   V T  + +H HD  G +  N L + + G   + ++V 
Sbjct: 183 LADTVGILNPTTTNYLVSEIFKSVNT-AICIHCHDDLGMATANTLAAAEAGAKQLHTTVN 241

Query: 363 GLGGCPYAKGASGNVATEDVVYMLNGLGIKTNVDIGKLMSAGDFIGKQLG-RPSGSKTAI 421
            +G        +GN + E+V+  L         D  KL S  + + +  G  PS +K  +
Sbjct: 242 AIG------ERAGNASLEEVLVALRVQYGIERYDTTKLNSLSEMVSEYSGITPSVNKAVV 295

Query: 422 ALNRVTADA 430
             N  T ++
Sbjct: 296 GKNAFTHES 304


>LEU1_YERPE (Q8ZIG8) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 520

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 76/315 (24%), Positives = 127/315 (40%), Gaps = 27/315 (8%)

Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
           M + V I +   RDG Q  +  +    K+++   L   G+ ++E    VS          
Sbjct: 1   MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPG--DFESV 58

Query: 190 KDVMQAVHNLRGIRLPVLTPNL--KGFEAAVAAGAREVAVFASASESFSKSNINCSIEES 247
           + + Q V N R   L            EA   A A  + VF + S    +S +  S ++ 
Sbjct: 59  RTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDV 118

Query: 248 LSR-YRAVTRAAKELSIPVRGYVSCV-VGCPVEGPVPPSKVAYVAKALYDMGCFEISLGD 305
           L+    +V RA        R Y   V   C   G  P   +  V +A    G   I++ D
Sbjct: 119 LAMAVHSVKRA--------RNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPD 170

Query: 306 TIGVGTP---GTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVA 362
           T+G  TP   G ++  L   +  +    ++VH HD  G S+ N + ++Q G   V+ ++ 
Sbjct: 171 TVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTIN 230

Query: 363 GLGGCPYAKGASGNVATEDVVYML----NGLGIKTNVDIGKLMSAGDFIGKQLGRPSGSK 418
           GLG        +GN + E+V+  +      LG+ TN++  ++      + K    P    
Sbjct: 231 GLG------ERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGN 284

Query: 419 TAIALNRVTADASKI 433
            AI  +   A +S I
Sbjct: 285 KAIVGSNAFAHSSGI 299


>LEU1_BACSU (P94565) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 518

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 68/304 (22%), Positives = 125/304 (40%), Gaps = 29/304 (9%)

Query: 142 RDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAKDVMQAVHNLRG 201
           RDG Q+    + T  K+ +  +L   G  +IEA    S +      D   V +    ++ 
Sbjct: 12  RDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSR-----GDFLAVQEIARTIKN 66

Query: 202 IRLPVLTPNLKG-----FEAAVAAGAREVAVFASASESFSKSNINCSIEESLSRYRAVTR 256
             +  L   +KG     +EA        + VF + S+   K  +  + E+ + R   + +
Sbjct: 67  CSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIERAVGMVK 126

Query: 257 AAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVGTP---G 313
            AKE   P+  + S    C  E P     +A + + + D G   I+L DT+G   P   G
Sbjct: 127 YAKE-RFPIVQW-SAEDACRTELPF----LAEIVEKVIDAGASVINLPDTVGYLAPAEYG 180

Query: 314 TVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYAKGA 373
            +   +   +  +   KL+ H HD  G ++ N L +++ G   ++ +V G+G        
Sbjct: 181 NIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIG------ER 234

Query: 374 SGNVATEDVVYMLNG----LGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIALNRVTAD 429
           +GN A E++   L+       ++T + + ++    D + K  G       A+  +   A 
Sbjct: 235 AGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAH 294

Query: 430 ASKI 433
            S I
Sbjct: 295 ESGI 298


>LE12_METKA (Q8TYM1) 2-isopropylmalate synthase 2 (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase 2) (Alpha-IPM synthetase
           2)
          Length = 509

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 73/304 (24%), Positives = 126/304 (41%), Gaps = 21/304 (6%)

Query: 131 PEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAK 190
           P+ V+I +   RDG Q     +  + K+ +  +L   G+  IEA    + +      + K
Sbjct: 11  PDEVRIFDTTLRDGEQTPGVALTPEEKLRIARKLDEIGVDTIEAGFAAASE-----GELK 65

Query: 191 DVMQAVHNLRGIRLPVLTPNLKG-FEAAVAAGAREVAVFASASESFSKSNINCSIEESLS 249
            + +         +  +   +KG  +AAV A A  V +    SE   K  +    EE L 
Sbjct: 66  AIRRIAREELDAEVCSMARMVKGDVDAAVEAEADAVHIVVPTSEVHVKKKLRMDREEVLE 125

Query: 250 RYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGV 309
           R R V   A++  + V   +S   G   E       +  V  A  + G   +   DT+GV
Sbjct: 126 RAREVVEYARDHGLTVE--ISTEDGTRTE----LEYLYEVFDACLEAGAERLGYNDTVGV 179

Query: 310 GTPGTVVPMLLAVMAIVPTEK-LAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCP 368
             P  +   +  +   V  +  L+VH HD +G +  N + +++ G   V  +V G+G   
Sbjct: 180 MAPEGMFLAVKKLRERVGEDVILSVHCHDDFGMATANTVAAVRAGARQVHVTVNGIG--- 236

Query: 369 YAKGASGNVATEDVVYMLNGL-GIKTNVDIGKLMSAGDFIGKQLG-RPSGSKTAIALNRV 426
                +GN A E+VV +L  L G+ T +   +L      + +  G R   +K  +  N  
Sbjct: 237 ---ERAGNAALEEVVVVLEELYGVDTGIRTERLTELSKLVERLTGVRVPPNKAVVGENAF 293

Query: 427 TADA 430
           T ++
Sbjct: 294 THES 297


>LEU1_VIBCH (Q9KP83) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 516

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 72/298 (24%), Positives = 125/298 (41%), Gaps = 25/298 (8%)

Query: 134 VKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADAKDVM 193
           V I +   RDG Q     +    K+++ + L   G+ +IEA   VS        D + V 
Sbjct: 5   VIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDIIEAGFPVSSP-----GDFESVQ 59

Query: 194 QAVHNLRGIRLPVLTPNL-KGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSR-Y 251
               N++  R+  L+  + K  +AA  A A +VA         S S I+  +++ L R Y
Sbjct: 60  TIAKNIKNSRVCALSRAVAKDIDAA--AEALKVAEAFRIHTFISTSTIH--VQDKLRRSY 115

Query: 252 RAVTRAAKELSIPVRGYVSCV-VGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIGVG 310
             V   A +     R Y   V   C   G  P   +  + +A  + G   I++ DT+G  
Sbjct: 116 DDVVAMAVKAVKHARQYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYT 175

Query: 311 TP---GTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGC 367
            P   G ++  L   +  +    ++VH HD  G S+ N + ++Q G   V+ ++ G+G  
Sbjct: 176 VPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGIG-- 233

Query: 368 PYAKGASGNVATEDVVYMLNG----LGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAI 421
                 +GN A E++  ++      LG+ T +   ++      + +    P  S  AI
Sbjct: 234 ----ERAGNCALEEIAMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAI 287


>LEU1_VIBVY (Q7MP77) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 515

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 69/306 (22%), Positives = 126/306 (40%), Gaps = 33/306 (10%)

Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
           M + V I +   RDG Q     +    K+++ + L   G+ VIEA   VS        D 
Sbjct: 1   MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSP-----GDF 55

Query: 190 KDVMQAVHNLRGIRLPVLTPNLK-----GFEAAVAAGAREVAVFASASESFSKSNINCSI 244
           + V     N++  R+  L+  ++       EA   A A  +  F S S    +  +  S 
Sbjct: 56  ESVQTIARNIKNSRVCALSRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSY 115

Query: 245 EESLSR-YRAVTRAAKELSIPVRGYVSCV-VGCPVEGPVPPSKVAYVAKALYDMGCFEIS 302
           ++ +    RAV  A K        Y   V   C   G  P   +  + +A  + G   I+
Sbjct: 116 DDVVEMGVRAVKHARK--------YTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTIN 167

Query: 303 LGDTIGVGTP---GTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDS 359
           + DT+G   P   G ++  L   +  +    ++VH HD  G S+ N + ++Q G   V+ 
Sbjct: 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEG 227

Query: 360 SVAGLGGCPYAKGASGNVATEDVVYMLNG----LGIKTNVDIGKLMSAGDFIGKQLGRPS 415
           ++ G+G        +GN + E++  ++      LG++T ++  ++      + +    P 
Sbjct: 228 TINGIG------ERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPI 281

Query: 416 GSKTAI 421
            +  AI
Sbjct: 282 QANKAI 287


>LEU1_VIBVU (Q8DEE1) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 515

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 69/306 (22%), Positives = 126/306 (40%), Gaps = 33/306 (10%)

Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
           M + V I +   RDG Q     +    K+++ + L   G+ VIEA   VS        D 
Sbjct: 1   MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSP-----GDF 55

Query: 190 KDVMQAVHNLRGIRLPVLTPNLK-----GFEAAVAAGAREVAVFASASESFSKSNINCSI 244
           + V     N++  R+  L+  ++       EA   A A  +  F S S    +  +  S 
Sbjct: 56  ESVQTIARNIKNSRVCALSRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSY 115

Query: 245 EESLSR-YRAVTRAAKELSIPVRGYVSCV-VGCPVEGPVPPSKVAYVAKALYDMGCFEIS 302
           ++ +    RAV  A K        Y   V   C   G  P   +  + +A  + G   I+
Sbjct: 116 DDVVEMGVRAVKHARK--------YTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTIN 167

Query: 303 LGDTIGVGTP---GTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDS 359
           + DT+G   P   G ++  L   +  +    ++VH HD  G S+ N + ++Q G   V+ 
Sbjct: 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEG 227

Query: 360 SVAGLGGCPYAKGASGNVATEDVVYMLNG----LGIKTNVDIGKLMSAGDFIGKQLGRPS 415
           ++ G+G        +GN + E++  ++      LG++T ++  ++      + +    P 
Sbjct: 228 TINGIG------ERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPI 281

Query: 416 GSKTAI 421
            +  AI
Sbjct: 282 QANKAI 287


>LEU1_DEIRA (Q9RUA9) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 522

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 73/311 (23%), Positives = 132/311 (41%), Gaps = 25/311 (8%)

Query: 132 EFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEA-TSFVSPKWVPQLADAK 190
           + ++I +   RDG Q+    +    K+E+ H LA  G+ VIEA     SP       D +
Sbjct: 14  QHIRIFDTTLRDGEQSPGVALNHAQKLEIAHTLARMGVDVIEAGFPIASP------GDLE 67

Query: 191 DVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAR--EVAVFASASESFSKSNINCSIEESL 248
            V +    +RG   PV+T   +   A + A A+  E A  +      + S I+   + +L
Sbjct: 68  GVSRIAREVRG---PVITALARANRADIEAAAKGVEAAEKSRIHTFIATSPIHMQKKLNL 124

Query: 249 SRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPP-SKVAYVAKALYDMGCFEISLGDTI 307
                + RA + + +  R YV  V     +        ++ + KA  + G   I++ DT+
Sbjct: 125 EPDAVIERAVEAVRL-ARQYVDDVEFSAEDATRSEWDFLSRIFKAAVEAGATTINVPDTV 183

Query: 308 GVGTPGTVVPMLLAVMAIVPTEK-LAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGG 366
           G  TP  +  +   + A +P    L+ H HD  G ++ N + + + G   ++ ++ G+G 
Sbjct: 184 GYTTPEEMRKLFAYLKAKLPAHVILSSHCHDDLGMAVANSIAAAEGGARQIECTINGIG- 242

Query: 367 CPYAKGASGNVATEDVVYMLNG----LGIKTNVDIGKLMSAGDFIGKQLGRPSGSKTAIA 422
                  +GN + E++V   +      G +T +   +L  A   + +  G P     AI 
Sbjct: 243 -----ERAGNASLEEIVMAFHTRRDVYGYETGIRTRELYRASRLVSRLSGMPVQPNKAIV 297

Query: 423 LNRVTADASKI 433
            +   A  S I
Sbjct: 298 GDNAFAHESGI 308


>CIMA_METKA (Q8TYB1) (R)-citramalate synthase (EC 2.3.3.-)
          Length = 499

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 27/265 (10%)

Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
           MP+ V+I +   RDG Q     +  + K+E+  +L   G+  IEA   V+         +
Sbjct: 1   MPDRVRIFDTTLRDGEQTPGVSLTVEEKVEIARKLDEFGVDTIEAGFPVA---------S 51

Query: 190 KDVMQAVHNLRGIRLPV----LTPNLKG-FEAAVAAGAREVAVFASASESFSKSNINCSI 244
           +   +AV  + G  L      L   +KG  +AA+ A    V VF + S+   +  +  S 
Sbjct: 52  EGEFEAVRAIAGEELDAEICGLARCVKGDIDAAIDADVDCVHVFIATSDIHLRYKLEMSR 111

Query: 245 EESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLG 304
           EE+L R       A +  + V                    +  V KA  + G   +++ 
Sbjct: 112 EEALERAIEGVEYASDHGVTVE------FSAEDATRTDRDYLLEVYKATVEAGADRVNVP 165

Query: 305 DTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGL 364
           DT+GV TP  +  +   V+  V    ++VH H+ +G ++ N L +++ G   V  +V G+
Sbjct: 166 DTVGVMTPPEMYRLTAEVVDAVDV-PVSVHCHNDFGMAVANSLAAVEAGAEQVHVTVNGI 224

Query: 365 GGCPYAKGASGNVATEDVVYMLNGL 389
           G        +GN + E VV  L  L
Sbjct: 225 G------ERAGNASLEQVVMALKAL 243


>LEU1_GLOVI (Q7NI93) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 538

 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 61/252 (24%), Positives = 113/252 (44%), Gaps = 18/252 (7%)

Query: 142 RDGLQNEKNIVPTDVKIELIHRLASTGLSVIEA-TSFVSPKWVPQLADAKDVMQAVHNLR 200
           RDG Q+    +  D K+E+  +LA  G+ VIEA  ++ SP       D + V +    + 
Sbjct: 14  RDGEQSPGATLNADEKVEIARQLARLGVDVIEAGFAYASP------GDFEAVERVARTVG 67

Query: 201 GIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEESLSRYRA-VTRAAK 259
               PV+    +   + + A A  +   A        S  +  +E  L + RA V   A 
Sbjct: 68  TEDGPVICSLARAIRSDIQAAAEAIRPAARGRIHTFISTSDIHLEHQLRKSRAEVLAIAA 127

Query: 260 ELSIPVRGYVSCVVGCPVE-GPVPPSKVAYVAKALYDMGCFEISLGDTIGVGTP---GTV 315
           E+    +G+V  V   P++ G   P  +  V +A    G   +++ DT+G  TP   G +
Sbjct: 128 EMVAFAKGFVDDVEFSPMDAGRSAPEYLYRVLEAAIAAGATTVNIPDTVGYLTPAEFGGL 187

Query: 316 VPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCPYAKGASG 375
           +  +   +  +    ++VH H+  G ++ N L +++ G   ++ +V G+G        +G
Sbjct: 188 IRGITQNVRGIERAVISVHCHNDLGLAVANSLAAIENGARQIECTVNGIG------ERAG 241

Query: 376 NVATEDVVYMLN 387
           N + E++V  L+
Sbjct: 242 NCSLEEIVMALH 253


>LEU1_PHOLL (Q7N129) 2-isopropylmalate synthase (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)
          Length = 520

 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 65/316 (20%), Positives = 129/316 (40%), Gaps = 29/316 (9%)

Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
           M + V I +   RDG Q  +  +  + K+++   L   G+ ++E    VS        D 
Sbjct: 1   MNQQVIIFDTTLRDGEQALQASLCVNEKLQIALALERMGVDIMEVGFPVSSP-----GDF 55

Query: 190 KDVMQAVHNLRGIRLPVLTPNLK-----GFEAAVAAGAREVAVFASASESFSKSNINCSI 244
           + V      ++  R+  L   ++       EA   A A  + VF + S+   +S +  + 
Sbjct: 56  ESVQTIAKQIKNSRVCALARCVEKDIDVAAEALKVADAFRIHVFLATSDLHIESKLKKTF 115

Query: 245 EESLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLG 304
           E  +       + A+  +  V         C   G  P   +  + +     G   I++ 
Sbjct: 116 ENVMEMATQSIKRARRYTDDVE------FSCEDAGRTPIDNLCRIVENAIKAGATTINIP 169

Query: 305 DTIGVGTP---GTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSV 361
           DT+G  TP   G ++  L+  +  +    ++VH HD  G S+ N + ++Q G   ++ ++
Sbjct: 170 DTVGYTTPYQFGGIITNLIERVPNIDKAIISVHCHDDLGMSVANSITAVQSGARQIEGTI 229

Query: 362 AGLGGCPYAKGASGNVATEDVVYML----NGLGIKTNVDIGKLMSAGDFIGKQLGRPSGS 417
            GLG        +GN + E+V+  +      LG+ TN++  ++      + +    P  +
Sbjct: 230 NGLG------ERAGNCSLEEVIMAIKVRQQMLGVYTNINHQEIYRTSQLVSQLCNMPIPA 283

Query: 418 KTAIALNRVTADASKI 433
             AI  +   + +S I
Sbjct: 284 NKAIVGSNAFSHSSGI 299


>LE11_SULTO (Q974X3) 2-isopropylmalate synthase 1 (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase 1) (Alpha-IPM synthetase
           1)
          Length = 386

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 66/292 (22%), Positives = 124/292 (41%), Gaps = 36/292 (12%)

Query: 134 VKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEAT-------SFVSPKWVPQL 186
           V+I +   RDG Q     +  + K+++  +LA  G+ VIEA         F++ K +  L
Sbjct: 12  VRIFDTTLRDGEQAPGIDLTVEQKVKIARKLAELGVDVIEAGFPAASEGEFIATKKI--L 69

Query: 187 ADAKDVMQAVHNLRGIRLPVLTPNLKGFEAAVAAGAREVAVFASASESFSKSNINCSIEE 246
            +  D ++ +   R         N +  +  +  G   + VF + S+   K  +  + E+
Sbjct: 70  EEVGDQVEVIGLSRA--------NKQDIDKTIDTGISSIHVFIATSDIHLKYKLKMTREQ 121

Query: 247 SLSRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKAL---YDMGCFEISL 303
            L +     R AK+  +        +V    E      K  ++ KA+    + G   I++
Sbjct: 122 VLDKIYESVRYAKDHGL--------IVEYSPEDATRTDK-DFLLKAVSTAIEAGADRINI 172

Query: 304 GDTIGVGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAG 363
            DT+GV  P     ++  V+++   + ++VH H+ +G +  N +  +  G   V  +V G
Sbjct: 173 PDTVGVMHPFKFHDLIKDVVSVTKDKIVSVHCHNDFGLATANSIAGVMAGARQVHVTVNG 232

Query: 364 LGGCPYAKGASGNVATEDVVYMLNG-LGIKTNVDIGKLMSAGDFIGKQLGRP 414
           +G        +GN + E+VV  L   LG + N+   KL      + +  G P
Sbjct: 233 IG------ERAGNASLEEVVMALKKLLGYEVNIKTYKLYETSRLVSELTGVP 278


>LE11_METKA (Q8TW28) 2-isopropylmalate synthase 1 (EC 2.3.3.13)
           (Alpha-isopropylmalate synthase 1) (Alpha-IPM synthetase
           1)
          Length = 397

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 65/261 (24%), Positives = 107/261 (40%), Gaps = 19/261 (7%)

Query: 130 MPEFVKIVEVGPRDGLQNEKNIVPTDVKIELIHRLASTGLSVIEATSFVSPKWVPQLADA 189
           +P+ V + +   RDG Q        + K+E+ H L   G+  IEA   V  +      + 
Sbjct: 15  LPDEVIVYDTTLRDGEQTPGVSFTPEQKLEIAHLLDELGVQQIEAGFPVVSE-----GER 69

Query: 190 KDVMQAVHNLRGIRLPVLTPNLKG-FEAAVAAGAREVAVFASASESFSKSNINCSIEESL 248
             V +  H      +  L   L+G  +AA+      V  F + SE   K  +  S EE L
Sbjct: 70  DAVRRIAHEGLNADILCLARTLRGDVDAALDCDVDGVITFIATSELHLKHKLRMSREEVL 129

Query: 249 SRYRAVTRAAKELSIPVRGYVSCVVGCPVEGPVPPSKVAYVAKALYDMGCFEISLGDTIG 308
            R       AK+  + V    S   G   E       +  V +   + G   +   DT+G
Sbjct: 130 ERIADTVEYAKDHGLWVA--FSAEDGTRTEFEF----LERVYRTAEECGADRVHATDTVG 183

Query: 309 VGTPGTVVPMLLAVMAIVPTEKLAVHFHDTYGQSLPNILVSLQMGISAVDSSVAGLGGCP 368
           V  P  +   +  +  +V    + VH HD +G ++ N L +++ G  A+ ++V G+G   
Sbjct: 184 VMIPAAMRLFVAKIREVVDLP-IGVHCHDDFGMAVANSLAAVEAGAQAISTTVNGIG--- 239

Query: 369 YAKGASGNVATEDVVYMLNGL 389
                +GN A E+V+  L  L
Sbjct: 240 ---ERAGNAALEEVIMALKEL 257


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.316    0.133    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,533,301
Number of Sequences: 164201
Number of extensions: 2040192
Number of successful extensions: 6159
Number of sequences better than 10.0: 154
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 100
Number of HSP's that attempted gapping in prelim test: 5968
Number of HSP's gapped (non-prelim): 174
length of query: 433
length of database: 59,974,054
effective HSP length: 113
effective length of query: 320
effective length of database: 41,419,341
effective search space: 13254189120
effective search space used: 13254189120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)