BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC146862.17 + phase: 0 
         (310 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

TRA1_PARUW (Q6MEE7) tRNA pseudouridine synthase A 1 (EC 4.2.1.70...   195  1e-49
TRUA_THETN (Q8R7Y7) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   171  2e-42
TRA1_CLOPE (Q8XLQ0) tRNA pseudouridine synthase A 1 (EC 4.2.1.70...   171  2e-42
TRUA_OCEIH (Q8CXP1) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   170  5e-42
TRUA_BACSU (P70973) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   169  8e-42
TRUA_CHLPN (Q9Z7X4) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   168  2e-41
TRUA_CHLMU (Q9PJT0) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   166  5e-41
TRA1_BACCR (Q814C2) tRNA pseudouridine synthase A 1 (EC 4.2.1.70...   166  5e-41
TRA1_CLOTE (Q893H3) tRNA pseudouridine synthase A 1 (EC 4.2.1.70...   166  7e-41
TRA1_BACC1 (Q73F64) tRNA pseudouridine synthase A 1 (EC 4.2.1.70...   165  1e-40
TRUA_CHLTR (O84469) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   162  1e-39
TRA2_CLOPE (Q8XHV5) tRNA pseudouridine synthase A 2 (EC 4.2.1.70...   160  5e-39
TRA2_CLOTE (Q890R5) tRNA pseudouridine synthase A 2 (EC 4.2.1.70...   159  1e-38
TRA2_BACCR (Q813Z9) tRNA pseudouridine synthase A 2 (EC 4.2.1.70...   159  1e-38
TRA2_BACC1 (Q73E17) tRNA pseudouridine synthase A 2 (EC 4.2.1.70...   158  1e-38
TRUA_LACPL (Q88XU9) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   157  2e-38
TRUA_LISIN (Q927P1) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   153  5e-37
TRUA_LACJO (Q74L59) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   152  8e-37
TRUA_BACSP (Q45557) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   150  5e-36
TRUA_BACHD (Q9Z9J0) tRNA pseudouridine synthase A (EC 4.2.1.70) ...   149  7e-36

>TRA1_PARUW (Q6MEE7) tRNA pseudouridine synthase A 1 (EC 4.2.1.70)
           (Pseudouridylate synthase I 1) (Pseudouridine synthase I
           1) (Uracil hydrolyase 1)
          Length = 256

 Score =  195 bits (495), Expect = 1e-49
 Identities = 98/255 (38%), Positives = 160/255 (62%), Gaps = 7/255 (2%)

Query: 32  WRLLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQ 91
           ++L ++YDGT Y+GWQ Q +  ++Q  +++AL     L+++ + LVG+ RTDAGVHA GQ
Sbjct: 4   YKLTIAYDGTNYSGWQIQPNASSIQQKIQEAL--CILLKKEKVVLVGSGRTDAGVHAKGQ 61

Query: 92  VAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTI 151
           VAHF    +Y +L  +H +LNGLLP DIR++ + P S  FH+++S   K YHY ++ + +
Sbjct: 62  VAHFHFQ-DYIDLSRLHVSLNGLLPRDIRIKAVEPVSPRFHSQYSAIRKEYHYYLHLNKV 120

Query: 152 MDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASH-NDRIPDPVKHIFPIDVK 210
           MDPFQR +++H   K++   +++AA  F G HDFT+F N +H      +PV+ ++ +D+K
Sbjct: 121 MDPFQRLYSWHFQRKIDVNILKKAAILFTGTHDFTSFANEAHRGTAAKNPVRTLYRLDIK 180

Query: 211 EMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLP 270
                L+LE EG GFLY+ VRN+V  L+ +       + +  I A+++R++ +      P
Sbjct: 181 PNEGGLRLEFEGDGFLYKMVRNIVGTLMDVASHKRAIEEINQIFAAKNRRQAS---LAAP 237

Query: 271 PHGLCLVSINYNESH 285
           P GL L+ + Y   +
Sbjct: 238 PEGLFLIQVFYENEN 252


>TRUA_THETN (Q8R7Y7) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 240

 Score =  171 bits (434), Expect = 2e-42
 Identities = 103/248 (41%), Positives = 147/248 (58%), Gaps = 9/248 (3%)

Query: 34  LLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQVA 93
           L++ YDGT Y GWQYQ++  TVQ  +EKA+ + T    + + L+G+SRTD GVHA  QVA
Sbjct: 2   LIIEYDGTNYHGWQYQKNAITVQEVLEKAIEKVTG---EKVNLIGSSRTDTGVHALYQVA 58

Query: 94  HFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIMD 153
           +F T       + +  ALN +LP D+ V +       FHAR+S +SK Y Y I +     
Sbjct: 59  NFKTKTKIPP-EKLPYALNAVLPDDVVVVKAKEVDKSFHARYSARSKRYRYLILNRQFPM 117

Query: 154 PFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEMG 213
           P  R++ +H  Y L+  AM++AA +F G HDF+AF+ AS N ++ +PVK IF + V++ G
Sbjct: 118 PTMRNYCWHVPYPLDVEAMKKAAFFFRGTHDFSAFK-ASGNKKV-NPVKTIFDLTVEKEG 175

Query: 214 ALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPHG 273
            L+++EVE  GFLY  VR +V  L+ +G        +P I+ S+DR    K     PP G
Sbjct: 176 DLIKIEVEADGFLYNMVRIIVGTLVYVGLGKIKAGEIPAIIESKDR---TKAGITAPPQG 232

Query: 274 LCLVSINY 281
           L LV I Y
Sbjct: 233 LYLVRIVY 240


>TRA1_CLOPE (Q8XLQ0) tRNA pseudouridine synthase A 1 (EC 4.2.1.70)
           (Pseudouridylate synthase I 1) (Pseudouridine synthase I
           1) (Uracil hydrolyase 1)
          Length = 248

 Score =  171 bits (434), Expect = 2e-42
 Identities = 101/253 (39%), Positives = 143/253 (55%), Gaps = 13/253 (5%)

Query: 33  RLLLSYDGTRYAGWQYQESP----PTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHA 88
           ++ L YDG++Y GWQ Q        TVQ  +EK L   TK+  +++QL+G  RTD+GVHA
Sbjct: 5   KITLDYDGSKYKGWQKQNQKGSNVSTVQDKLEKVL---TKMTSEEIQLIGCGRTDSGVHA 61

Query: 89  WGQVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYS 148
              VA+F T  +   L+ +   +N  LP DIRV EI  AS  FHARF+VKSK Y Y I +
Sbjct: 62  KNYVANFKTN-SLMTLEQIIEYINEYLPEDIRVTEIREASERFHARFNVKSKTYEYTIDN 120

Query: 149 DTIMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPID 208
           +   D F R +A+H   KL+  AM E A+Y +G HDF +F +    ++    ++ I  I+
Sbjct: 121 NKFKDVFLRKYAWHVEEKLDLEAMEEGAKYLLGTHDFKSFTSLKSKNK--STLRTINSIE 178

Query: 209 VKEMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYY 268
             E   +L +++ G+GFL   VR MV  L+ +G     P  +  IL   + KE AK    
Sbjct: 179 FHENNNILSIKINGNGFLLNMVRIMVGTLVDVGLGKIEPKYINDIL---EAKERAKASEK 235

Query: 269 LPPHGLCLVSINY 281
            P HGLCL+ +NY
Sbjct: 236 APAHGLCLLELNY 248


>TRUA_OCEIH (Q8CXP1) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 253

 Score =  170 bits (430), Expect = 5e-42
 Identities = 94/249 (37%), Positives = 148/249 (58%), Gaps = 7/249 (2%)

Query: 36  LSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQVAHF 95
           +SYDG+ +AG+Q Q    TVQ  +EKAL    K   K +++  + RTD GVHA GQV HF
Sbjct: 8   VSYDGSDFAGFQVQPDHRTVQGVLEKALYNMHK--GKSIRIQASGRTDTGVHAVGQVIHF 65

Query: 96  LTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIMDPF 155
            +P      +   A LN LLP D+R++++   + EFHAR+SVK K YHY + ++   + F
Sbjct: 66  DSPLEIPERNWKQA-LNTLLPDDVRIQKVEKKTEEFHARYSVKEKEYHYFVLNEEDPNVF 124

Query: 156 QRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEMGAL 215
           QR + YH   KL+   M+EA +Y  G HDFT+F +A  + +    V+ ++ +   + G  
Sbjct: 125 QRGYVYHEPRKLDLERMQEACQYLEGTHDFTSFSSAKSSVK-GSKVRTLYHVSCHQTGTN 183

Query: 216 LQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPHGLC 275
           ++    GSGFLY  VR M+++L+ +GK    P+ +  +LAS++R+++ K    + P GL 
Sbjct: 184 IEFIFRGSGFLYNMVRIMMSVLIDVGKGKRNPEDIIDLLASKNRQQIGK---TMAPQGLY 240

Query: 276 LVSINYNES 284
           L  ++Y E+
Sbjct: 241 LWRVSYEEN 249


>TRUA_BACSU (P70973) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 247

 Score =  169 bits (428), Expect = 8e-42
 Identities = 102/247 (41%), Positives = 141/247 (56%), Gaps = 7/247 (2%)

Query: 36  LSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQVAHF 95
           +SYDG  + G+Q Q    TVQ  +EKAL    K + + + +V + RTD+GVHA GQV HF
Sbjct: 7   ISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDR-IPVVSSGRTDSGVHAAGQVIHF 65

Query: 96  LTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIMDPF 155
            TP +    +    ALN LLP DI V++   A   FHARFS   K Y Y +Y++   D F
Sbjct: 66  DTPLSIP-AERWPYALNALLPDDIAVKQAEIADDGFHARFSAVKKEYRYFVYTEKHPDVF 124

Query: 156 QRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEMGAL 215
           +RH+AYH  Y+LN   MREAA++ IG HDFT+F   +    + D V+ I+ +D  E    
Sbjct: 125 KRHYAYHFSYRLNVQDMREAAKHPIGTHDFTSF--CAAKTEVQDKVRTIYELDWTETADG 182

Query: 216 LQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPHGLC 275
           LQ+ + GSGFLY  VR +   LL  G     PD V  +L ++DR+   +     P HGL 
Sbjct: 183 LQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVKSMLEAKDREAAERTA---PGHGLY 239

Query: 276 LVSINYN 282
           L ++ Y+
Sbjct: 240 LWNVYYD 246


>TRUA_CHLPN (Q9Z7X4) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 267

 Score =  168 bits (425), Expect = 2e-41
 Identities = 96/252 (38%), Positives = 142/252 (56%), Gaps = 9/252 (3%)

Query: 31  KWRLLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWG 90
           K  LL++Y GT Y+GWQ Q +  ++Q  +E +L + TK +     L+ + RTDAGVHA+G
Sbjct: 3   KVALLIAYQGTAYSGWQQQPNDLSIQEVIESSLKKITKTRTP---LIASGRTDAGVHAYG 59

Query: 91  QVAHFLTPFN--YDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYS 148
           QVAHF  P +  + N +    ALN +LP DI +R+++     FHAR+   +K Y Y +  
Sbjct: 60  QVAHFRAPDHPLFANANLTKKALNAILPKDIVIRDVALFDDNFHARYLTIAKEYRYSLSR 119

Query: 149 DTIMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPID 208
                P+QRHF Y   +  ++  M+E A   IG HDF +F N  H       V+ I+ +D
Sbjct: 120 LAKPLPWQRHFCYTPRHPFSTELMQEGANLLIGTHDFASFAN--HGRDYNSTVRTIYTLD 177

Query: 209 VKEMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKE--LAKYC 266
           + + G  L +   G+GFLY+ VRN+V  LL +GK A PP+ +  IL  ++R+E   A   
Sbjct: 178 IVDKGDSLSIICRGNGFLYKMVRNLVGALLDVGKGAYPPEHLLDILEQKNRREGPSAAPA 237

Query: 267 YYLPPHGLCLVS 278
           Y L  H +C  S
Sbjct: 238 YGLSLHHVCYSS 249


>TRUA_CHLMU (Q9PJT0) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 267

 Score =  166 bits (421), Expect = 5e-41
 Identities = 94/250 (37%), Positives = 142/250 (56%), Gaps = 10/250 (4%)

Query: 34  LLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQVA 93
           L ++Y GT Y+GWQYQ +  ++Q  +E  L    K+ R  + ++ + RTDAGVHA GQVA
Sbjct: 7   LRIAYQGTAYSGWQYQPNALSIQEVLETLL---QKISRTRISVIASGRTDAGVHAQGQVA 63

Query: 94  HFLTPFN--YDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTI 151
           HF  P +  + +   +   LN LLP DI +R++   + +FH+RFS  +K YHY +     
Sbjct: 64  HFCCPDHPHFSDPGQIKKMLNALLPHDIVIRDVIATNEDFHSRFSAITKEYHYTLSLLPK 123

Query: 152 MDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKE 211
             P  R F +   +KL   +MREAA+Y +G HDF +F N          V+ ++ +D+ E
Sbjct: 124 PLPHHRLFCFSPRHKLCLESMREAAKYLVGTHDFASFANLGRE--YSSTVRTLYALDLLE 181

Query: 212 MGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPP 271
              L+ +  +G+GFLY+ VRN+V  LL IGK   PP+   H+L   ++K+  K     PP
Sbjct: 182 QEHLVTVICKGNGFLYKMVRNIVGALLDIGKGKYPPE---HLLEMLEKKDRKKGPPSAPP 238

Query: 272 HGLCLVSINY 281
           +GL L  + Y
Sbjct: 239 YGLSLHHVCY 248


>TRA1_BACCR (Q814C2) tRNA pseudouridine synthase A 1 (EC 4.2.1.70)
           (Pseudouridylate synthase I 1) (Pseudouridine synthase I
           1) (Uracil hydrolyase 1)
          Length = 247

 Score =  166 bits (421), Expect = 5e-41
 Identities = 99/248 (39%), Positives = 144/248 (57%), Gaps = 10/248 (4%)

Query: 36  LSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGAS-RTDAGVHAWGQVAH 94
           ++YDG  + G+Q Q +  TVQ  +EKAL    KL + +L  V AS RTD+ VHA GQV H
Sbjct: 8   VAYDGMHFCGYQIQPNHRTVQQEIEKAL---QKLHKGELVRVQASGRTDSTVHAKGQVIH 64

Query: 95  FLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIMDP 154
           F TP + +     +A LN +LP DI +R++   + EFHAR+ V+ K Y Y++      D 
Sbjct: 65  FDTPLSLEEWQWSNA-LNTMLPDDIVIRQVEKKTEEFHARYGVEKKEYRYRVLLSKTADV 123

Query: 155 FQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEMGA 214
           F+R++ Y   Y L   ++R+A  YFIG HDFT+F +A  + +  D V+ I+ I++ E   
Sbjct: 124 FRRNYVYQYPYPLEINSIRKAIPYFIGTHDFTSFCSAKTDKK--DKVRTIYEIELIEQDD 181

Query: 215 LLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPHGL 274
            +     G+GFLY  VR +V  LL +G+    PD +P ILA ++R+   K     P HGL
Sbjct: 182 EIIFRFVGNGFLYNMVRIIVGTLLSVGQGKLDPDSIPEILAKQNRQFAGKMA---PGHGL 238

Query: 275 CLVSINYN 282
            L  +NYN
Sbjct: 239 YLWEVNYN 246


>TRA1_CLOTE (Q893H3) tRNA pseudouridine synthase A 1 (EC 4.2.1.70)
           (Pseudouridylate synthase I 1) (Pseudouridine synthase I
           1) (Uracil hydrolyase 1)
          Length = 245

 Score =  166 bits (420), Expect = 7e-41
 Identities = 96/250 (38%), Positives = 144/250 (57%), Gaps = 10/250 (4%)

Query: 33  RLLLSYDGTRYAGWQYQESPP-TVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQ 91
           +++L YDGTRY GWQ Q+    T+Q  +E  L   +K+  +D+Q++G  RTDAGVHA   
Sbjct: 5   KMILEYDGTRYKGWQKQKKDVLTIQDKIETVL---SKMTGEDIQVIGCGRTDAGVHAENY 61

Query: 92  VAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTI 151
           VA+F T  ++  +D +   L   LP DI V+ +   S  FHAR++VKSK Y Y+I ++  
Sbjct: 62  VANFHTNCDF-TVDYMLDYLYEFLPEDIVVKTMKDTSERFHARYNVKSKTYVYRINNNKF 120

Query: 152 MDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKE 211
              F + +AYH+  KLN +AM++AA + IG HDF +F     N +    ++ I  I++ E
Sbjct: 121 RSVFNKKYAYHDNEKLNISAMKDAAEFLIGTHDFKSFTRLKSNSK--STIRAIKYINITE 178

Query: 212 MGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPP 271
              ++ +EV G+GFL   VR +   LL++GKE   P  +  +L   + K+ A     LP 
Sbjct: 179 NQGIISIEVNGNGFLLNMVRIVAGALLEVGKENIKPIDIEKML---NEKKRADASLILPA 235

Query: 272 HGLCLVSINY 281
            GLCL  I Y
Sbjct: 236 KGLCLKDIQY 245


>TRA1_BACC1 (Q73F64) tRNA pseudouridine synthase A 1 (EC 4.2.1.70)
           (Pseudouridylate synthase I 1) (Pseudouridine synthase I
           1) (Uracil hydrolyase 1)
          Length = 247

 Score =  165 bits (418), Expect = 1e-40
 Identities = 100/248 (40%), Positives = 142/248 (56%), Gaps = 10/248 (4%)

Query: 36  LSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGAS-RTDAGVHAWGQVAH 94
           ++YDG  + G+Q Q    TVQ  +EKAL    KL + +L  V AS RTD+ VHA GQV H
Sbjct: 8   VAYDGMHFCGYQIQPQHRTVQQEIEKAL---QKLHKGELVRVQASGRTDSTVHAKGQVIH 64

Query: 95  FLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIMDP 154
           F TP + +     + ALN +LP DI + ++   + EFHAR+ V+ K Y Y++      D 
Sbjct: 65  FDTPLSLEEWQW-NNALNTMLPDDIVITQVEKKTEEFHARYGVERKEYRYRVLLSKTADV 123

Query: 155 FQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEMGA 214
           F+R++ Y   Y L   A+R+A  YFIG HDFT+F +A  + +  D V+ I+ I++ E   
Sbjct: 124 FRRNYVYQYPYPLEINAIRKAIPYFIGTHDFTSFCSAKTDKK--DKVRTIYEIELIEQDD 181

Query: 215 LLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPHGL 274
            L     G+GFLY  VR +V  LL +G+    PD +P ILA ++R+   K     P HGL
Sbjct: 182 ELIFRFVGNGFLYNMVRIIVGTLLSVGQGKLDPDSIPEILAKQNRQFAGKMA---PGHGL 238

Query: 275 CLVSINYN 282
            L  +NYN
Sbjct: 239 YLWQVNYN 246


>TRUA_CHLTR (O84469) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 267

 Score =  162 bits (410), Expect = 1e-39
 Identities = 97/259 (37%), Positives = 142/259 (54%), Gaps = 16/259 (6%)

Query: 34  LLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQVA 93
           L ++Y GT Y+GWQYQ +  ++Q  +E  L    K+    + ++ + RTDAGVHA GQ+A
Sbjct: 7   LQIAYQGTSYSGWQYQPNALSIQEVLETIL---KKIAGFRISVISSGRTDAGVHAQGQIA 63

Query: 94  HFLTPFNYDNLD--SVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTI 151
           HF  P +    D   +   LN LLP DI +R+      +FH+RFS  +K Y Y +     
Sbjct: 64  HFHCPDHPHFTDPRQIQKMLNALLPHDIVIRDAVMTDEDFHSRFSAIAKEYRYTLSLLPK 123

Query: 152 MDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKE 211
             P  R F +   YKLN A M+EAA+Y +G HDF +F N          ++ ++ +D+ E
Sbjct: 124 PLPHHRLFCFSPRYKLNIARMQEAAQYLVGTHDFASFANLGRE--YSSTIRTLYTLDLSE 181

Query: 212 MGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPP 271
              L+ +   G+GFLY+ VRN+V  LL IGK   PP+ +  +LA++DR+   K     PP
Sbjct: 182 QEHLVTVICRGNGFLYKMVRNIVGALLDIGKGKYPPEHLLDMLATKDRR---KGPPSAPP 238

Query: 272 HGLCLVSINYNESHLLPPP 290
           +GL L  + Y      PPP
Sbjct: 239 YGLSLHHVCY------PPP 251


>TRA2_CLOPE (Q8XHV5) tRNA pseudouridine synthase A 2 (EC 4.2.1.70)
           (Pseudouridylate synthase I 2) (Pseudouridine synthase I
           2) (Uracil hydrolyase 2)
          Length = 244

 Score =  160 bits (404), Expect = 5e-39
 Identities = 92/249 (36%), Positives = 141/249 (55%), Gaps = 9/249 (3%)

Query: 33  RLLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQV 92
           +L + YDGT Y GWQ Q    T+Q  VE+A+ + TK   ++++++G+SRTD+GVHA   V
Sbjct: 5   KLTIEYDGTSYFGWQKQPIGNTIQQKVEEAIKKVTK---EEVEILGSSRTDSGVHAKAYV 61

Query: 93  AHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIM 152
           A+F T  N     +  AALN  LP DI +      + +FHAR+    K Y Y I +    
Sbjct: 62  ANFKTNSNIPG-KNFKAALNSKLPKDIVIINSEEVAEDFHARYMTTGKTYCYTILNREEP 120

Query: 153 DPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEM 212
              +R++ YH   +L+  +M+EA +YF+GKHDF AF+       +   V+ I  I ++  
Sbjct: 121 PALERNYVYHVKKQLDVESMKEACKYFLGKHDFKAFQRP--GGTVKTSVRTITDIHIETE 178

Query: 213 GALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPH 272
           G  +++ V   GFLY  VR +V  LL++G+    P+ +  ++ S DRK+ A  C  +PP 
Sbjct: 179 GNKIKIYVSADGFLYNMVRLIVGTLLKVGRGKEKPEYIKEVIDSGDRKK-AGIC--VPPT 235

Query: 273 GLCLVSINY 281
           GLCL  + Y
Sbjct: 236 GLCLEKVFY 244


>TRA2_CLOTE (Q890R5) tRNA pseudouridine synthase A 2 (EC 4.2.1.70)
           (Pseudouridylate synthase I 2) (Pseudouridine synthase I
           2) (Uracil hydrolyase 2)
          Length = 248

 Score =  159 bits (401), Expect = 1e-38
 Identities = 95/252 (37%), Positives = 140/252 (54%), Gaps = 11/252 (4%)

Query: 33  RLLLSYDGTRYAGWQYQESP--PTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWG 90
           RL + YDGT Y+GWQ Q+     T+Q ++EKA+  ATK   ++++L+G+SRTDAGVHA  
Sbjct: 6   RLKVEYDGTNYSGWQKQKDKNIKTIQSSIEKAIEEATK---EEVELIGSSRTDAGVHALA 62

Query: 91  QVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDT 150
             A+F T          HA LN  LP DI + E      EFH+RF    K Y YKI +  
Sbjct: 63  YTANFKTCSTIPGEKFKHA-LNRFLPEDIVILESEEVPMEFHSRFDCIGKTYVYKILNRP 121

Query: 151 IMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVK 210
           +  P QR++ YH   +L+  +M EA+++ IG HDF AF+ +  N  +   V+ I  I++ 
Sbjct: 122 LFSPIQRNYIYHVKDELDINSMIEASKFLIGTHDFNAFKKSGGN--LKTTVRTITNINIL 179

Query: 211 EMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLP 270
           +   ++++ V G GFLY  VR +   L+++G     P+ +  IL S+DR    K     P
Sbjct: 180 KSNDIVEIHVSGDGFLYNMVRIISGTLIEVGLSRRKPEDISIILQSKDR---CKAGMCAP 236

Query: 271 PHGLCLVSINYN 282
             GL L  + YN
Sbjct: 237 ARGLYLKELFYN 248


>TRA2_BACCR (Q813Z9) tRNA pseudouridine synthase A 2 (EC 4.2.1.70)
           (Pseudouridylate synthase I 2) (Pseudouridine synthase I
           2) (Uracil hydrolyase 2)
          Length = 245

 Score =  159 bits (401), Expect = 1e-38
 Identities = 81/234 (34%), Positives = 136/234 (57%), Gaps = 7/234 (2%)

Query: 30  YKWRLLLSYDGTRYAGWQ-YQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHA 88
           + ++L + YDG R+ GWQ    +  T+Q  +E  +   +++  K+++++G SRTDAGVHA
Sbjct: 2   HNYKLTIQYDGARFKGWQRLGNNDNTIQGKIESVI---SEMVGKEIEIIGCSRTDAGVHA 58

Query: 89  WGQVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYS 148
             QVA+F +         V   LN  LP+DI +  +      FHAR++ K+K Y YKI++
Sbjct: 59  LNQVANFQSDEKLVE-HKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWN 117

Query: 149 DTIMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPID 208
           +   +PF R ++ H   KLN  +M+ AA++ +G HDFTAF NA    +    V+ ++ +D
Sbjct: 118 EEHTNPFMRKYSMHVNKKLNVKSMKAAAKHLVGSHDFTAFSNAKSKKK--SMVREVYTLD 175

Query: 209 VKEMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKEL 262
           V E    +Q+ V G+GFL+  VR +V  L+++G      + +P+IL  + R ++
Sbjct: 176 VMEEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLDAEAIPNILEEKQRNQI 229


>TRA2_BACC1 (Q73E17) tRNA pseudouridine synthase A 2 (EC 4.2.1.70)
           (Pseudouridylate synthase I 2) (Pseudouridine synthase I
           2) (Uracil hydrolyase 2)
          Length = 245

 Score =  158 bits (400), Expect = 1e-38
 Identities = 81/234 (34%), Positives = 136/234 (57%), Gaps = 7/234 (2%)

Query: 30  YKWRLLLSYDGTRYAGWQ-YQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHA 88
           + ++L + YDG R+ GWQ    +  T+Q  +E  +   +++  K+ +++G SRTDAGVHA
Sbjct: 2   HNYKLTIQYDGARFKGWQRLGNNDNTIQGKIESVI---SEMVGKETEIIGCSRTDAGVHA 58

Query: 89  WGQVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYS 148
             QVA+F +         V   LN  LP+DI +  +      FHAR++ K+K Y YKI++
Sbjct: 59  LNQVANFQSDEKLVE-HKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWN 117

Query: 149 DTIMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPID 208
           +   +PF R ++ H   KLN  +M+EAA++ +G HDFTAF NA    +    V+ ++ ++
Sbjct: 118 EEHTNPFMRKYSMHVNKKLNVKSMKEAAKHLVGSHDFTAFSNAKSKKK--SMVREVYTLE 175

Query: 209 VKEMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKEL 262
           V E    +Q+ V G+GFL+  VR +V  L+++G      + +P IL ++ R ++
Sbjct: 176 VMEEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLDAEAIPQILEAKQRNQI 229


>TRUA_LACPL (Q88XU9) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 262

 Score =  157 bits (398), Expect = 2e-38
 Identities = 92/262 (35%), Positives = 146/262 (55%), Gaps = 16/262 (6%)

Query: 31  KWRLLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWG 90
           +++++L+YDGT +AG+Q Q    TV+  V KA+ +  K   + + + GA RTDAGVHA+G
Sbjct: 4   RYKVVLAYDGTNFAGFQRQPHQRTVEQVVTKAVNKMAKDPVEPIVIYGAGRTDAGVHAFG 63

Query: 91  QVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDT 150
           Q  HF  P+   N + V   LN +LP D  V+ +S    +FHAR+    K Y Y+ Y + 
Sbjct: 64  QTLHFDLPYEI-NPEGVRRGLNSMLPMDTIVKAVSIVPNDFHARYDTVGKRYWYRAYQNE 122

Query: 151 IMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPI--- 207
            +DPF+RH+  H  +  +   +++A     G+HDF+ F   +   +  D V+ I+     
Sbjct: 123 FVDPFKRHYTGHFKFAADIDRIQQAIGDLEGRHDFSTF--VASGSQAHDHVREIYSAKAW 180

Query: 208 ---DVKEMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAK 264
              D +E    +Q E  GSGFLY QVR MVA+L++IG+     D +P +LA++DR++   
Sbjct: 181 ALPDERE----IQFEFCGSGFLYNQVRIMVAVLMEIGQGRRAVDCIPALLAAKDREQARG 236

Query: 265 YCYYLPPHGLCLVSINYNESHL 286
                P  GL +  + Y ++ L
Sbjct: 237 TA---PAAGLYMKKVYYEQNEL 255


>TRUA_LISIN (Q927P1) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 248

 Score =  153 bits (387), Expect = 5e-37
 Identities = 93/252 (36%), Positives = 136/252 (53%), Gaps = 8/252 (3%)

Query: 31  KWRLLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWG 90
           +++ ++SYDG+ + G+Q Q +  TVQ  +EKAL +  K   K +++  + RTD GVHA G
Sbjct: 3   RYKAIISYDGSGFFGYQVQPNTRTVQAEIEKALEKMHK--GKSVRITASGRTDTGVHAKG 60

Query: 91  QVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDT 150
           QV HF +  +    +    AL  + P DI    +  A A+FHARF    K Y Y I    
Sbjct: 61  QVIHFDSELDI-TAEKFQKALQVMTPFDISFLTVEEAPADFHARFGTVGKEYRYVIKRTK 119

Query: 151 IMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVK 210
           I DPF R+FA H  Y+L+ A M++A+   IG+HDFT+F   S        V+ ++ ID  
Sbjct: 120 IFDPFSRNFALHYPYELDIAKMKQASERLIGEHDFTSF--CSARTERDSKVRTLYSIDFY 177

Query: 211 EMGA-LLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYL 269
           E  A  L +  +G+GFLY  VR +   LL  G+    PD +   L + DR++L       
Sbjct: 178 EEDAETLVIAFQGNGFLYNMVRILTGTLLDAGQGRISPDDITKALLAHDRQKLISKT--A 235

Query: 270 PPHGLCLVSINY 281
           PP GL L  ++Y
Sbjct: 236 PPQGLYLWRVDY 247


>TRUA_LACJO (Q74L59) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 263

 Score =  152 bits (385), Expect = 8e-37
 Identities = 92/255 (36%), Positives = 143/255 (56%), Gaps = 9/255 (3%)

Query: 31  KWRLLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWG 90
           +++L ++YDG  + G+Q Q +  TVQ  +E+AL + TK +R  + + G+ RTDAGVHA G
Sbjct: 4   RYKLTMAYDGHLFHGFQIQPNQRTVQGVIEEALKKMTKGKR--VVVHGSGRTDAGVHAKG 61

Query: 91  QVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDT 150
           QV HF  P       ++  ALN L+P D    E      +FH ++S K K Y Y +    
Sbjct: 62  QVIHFDYPGKEIPAKNMMLALNALMPIDTVFFESEIVDEDFHVQYSTKGKWYRYVVDQHR 121

Query: 151 IMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVK 210
             DPF R +  H  Y L+ + M++AA+  IG+HDFT+F  A+   +I D V+ I+ +++ 
Sbjct: 122 FTDPFNRFYTGHYPYPLDISLMKQAAKDLIGEHDFTSF--AASGGQIVDKVRTIYYVNIT 179

Query: 211 EMGALLQL--EVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYY 268
                 Q+  +  G+GFLY  VR +V  LL+IG +  P D +P +L ++DR+E+      
Sbjct: 180 PDPDKKQIIFDFIGNGFLYNMVRILVGTLLEIGNKKRPVDDIPRVLKAKDRQEVRTTA-- 237

Query: 269 LPPHGLCLVSINYNE 283
            P  GL L  + Y +
Sbjct: 238 -PASGLYLQQVFYED 251


>TRUA_BACSP (Q45557) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 244

 Score =  150 bits (378), Expect = 5e-36
 Identities = 84/231 (36%), Positives = 131/231 (56%), Gaps = 7/231 (3%)

Query: 32  WRLLLSYDGTRYAGWQ-YQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWG 90
           ++L++ YDG RY GWQ       T+Q  +E  L   +++  + ++++G+ RTDAGVHA G
Sbjct: 4   YKLMIQYDGGRYKGWQRLGNGENTIQGKIETVL---SEMVGRKIEIIGSGRTDAGVHALG 60

Query: 91  QVAHFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDT 150
           QVA+     N+  +  V   LN  LP DI V E++     FH+R++ K K Y YKI+++ 
Sbjct: 61  QVANVKLSENF-TVKEVKEYLNRYLPHDISVTEVTLVPDRFHSRYNAKDKTYLYKIWNED 119

Query: 151 IMDPFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVK 210
              PF R ++ H   KL+   M +A++ F+G+HDFTAF NA    +     + I  I ++
Sbjct: 120 YTHPFMRKYSLHIEKKLHIDNMVKASQLFVGEHDFTAFSNAKSKKK--TNTRTIHSITIQ 177

Query: 211 EMGALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKE 261
           +    + + V G GFLY  VR MV  L+++G     P+ V  IL S+DR +
Sbjct: 178 DNQGFIDIRVCGDGFLYNMVRKMVGTLIEVGLGEKEPEQVLTILESKDRSQ 228


>TRUA_BACHD (Q9Z9J0) tRNA pseudouridine synthase A (EC 4.2.1.70)
           (Pseudouridylate synthase I) (Pseudouridine synthase I)
           (Uracil hydrolyase)
          Length = 263

 Score =  149 bits (377), Expect = 7e-36
 Identities = 91/241 (37%), Positives = 133/241 (54%), Gaps = 8/241 (3%)

Query: 34  LLLSYDGTRYAGWQYQESPPTVQCAVEKALIRATKLQRKDLQLVGASRTDAGVHAWGQVA 93
           L ++YDGT +AG+Q Q +  TVQ  +E  L    K     +++  + RTD GVHA GQ+ 
Sbjct: 6   LKVAYDGTDFAGYQIQPNERTVQGELESVLKNIHK--GMSIRVTASGRTDTGVHARGQIV 63

Query: 94  HFLTPFNYDNLDSVHAALNGLLPSDIRVREISPASAEFHARFSVKSKIYHYKIYSDTIMD 153
           HF T  ++  +D    ALN  LP+DI V E +   A+FHAR+S K+K Y Y++ +    D
Sbjct: 64  HFDTSLSFP-VDRWPIALNSQLPADICVLEAADVPADFHARYSAKTKEYRYRVLTSAQAD 122

Query: 154 PFQRHFAYHNMYKLNSAAMREAARYFIGKHDFTAFENASHNDRIPDPVKHIFPIDVKEMG 213
            F+R++ YH  Y L+  AM+ AA   +G HDF++F   +    + D V+ I  + +   G
Sbjct: 123 VFRRNYTYHVRYPLDVEAMQRAAVQLLGTHDFSSF--CAAKAEVEDKVRTIEDVALWREG 180

Query: 214 ALLQLEVEGSGFLYRQVRNMVALLLQIGKEATPPDIVPHILASRDRKELAKYCYYLPPHG 273
             L   + G+GFLY  VR +V  LL+IG      + V  ILA+R R+   K     P HG
Sbjct: 181 DELIFSIRGNGFLYNMVRIIVGTLLEIGAGKRSAEEVAKILAARSREAAGKTA---PGHG 237

Query: 274 L 274
           L
Sbjct: 238 L 238


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.322    0.137    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,239,400
Number of Sequences: 164201
Number of extensions: 1541997
Number of successful extensions: 4212
Number of sequences better than 10.0: 177
Number of HSP's better than 10.0 without gapping: 152
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 3552
Number of HSP's gapped (non-prelim): 182
length of query: 310
length of database: 59,974,054
effective HSP length: 110
effective length of query: 200
effective length of database: 41,911,944
effective search space: 8382388800
effective search space used: 8382388800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)