BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146792.2 + phase: 0
(577 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
IMA2_ARATH (O04294) Importin alpha-2 subunit (Karyopherin alpha-... 60 2e-08
VAC8_YEAST (P39968) Vacuolar protein 8 53 2e-06
IMA4_MOUSE (O35343) Importin alpha-4 subunit (Karyopherin alpha-... 47 2e-04
IMA4_HUMAN (O00629) Importin alpha-4 subunit (Karyopherin alpha-... 47 2e-04
CTNB_XENLA (P26233) Beta-catenin 47 2e-04
ARM_DROME (P18824) Armadillo segment polarity protein 45 4e-04
PLAK_BOVIN (Q8SPJ1) Junction plakoglobin (Desmoplakin III) 44 0.002
PKP4_HUMAN (Q99569) Plakophilin 4 (p0071) 44 0.002
CTNB_MOUSE (Q02248) Beta-catenin 44 0.002
CTNB_HUMAN (P35222) Beta-catenin (PRO2286) 44 0.002
IMA1_SCHPO (O14063) Importin alpha subunit (Karyopherin alpha su... 43 0.002
CTNB_RAT (Q9WU82) Beta-catenin 43 0.003
PLAK_MOUSE (Q02257) Junction plakoglobin (Desmoplakin III) (Frag... 42 0.004
CTD2_MOUSE (O35927) Catenin delta-2 (Neural plakophilin-related ... 42 0.004
PLAK_HUMAN (P14923) Junction plakoglobin (Desmoplakin III) 42 0.006
ARM_MUSDO (Q02453) Armadillo segment polarity protein 42 0.006
PKP1_HUMAN (Q13835) Plakophilin 1 (Band-6-protein) (B6P) 40 0.013
IMA_LYCES (O22478) Importin alpha subunit (Karyopherin alpha sub... 40 0.013
PLAK_XENLA (P30998) Junction plakoglobin (Desmoplakin III) 40 0.017
CTD2_HUMAN (Q9UQB3) Catenin delta-2 (Delta-catenin) (Neural plak... 40 0.022
>IMA2_ARATH (O04294) Importin alpha-2 subunit (Karyopherin alpha-2
subunit) (KAP alpha)
Length = 531
Score = 60.1 bits (144), Expect = 2e-08
Identities = 84/377 (22%), Positives = 154/377 (40%), Gaps = 48/377 (12%)
Query: 178 NLLEVVVEDEKYVKVIVVDVSDVVHVLVGFLGSNEV-EIQEESAKVVCVLA-GFDSYKGV 235
NLL ++ E+ + V S VV +V FL ++ ++Q E+A + +A G V
Sbjct: 97 NLLRKLLSIEQNPPINEVVQSGVVPRVVKFLSRDDFPKLQFEAAWALTNIASGTSENTNV 156
Query: 236 LISAGVIAPLIRVLDCGSELGKVAAARCLMKLTENSDNAW-AVSAHGGVTALLNICGNDD 294
+I +G + I++L SE + A L + +S V ++G +T LL+ +
Sbjct: 157 IIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKCRDLVLSYGAMTPLLSQFNENT 216
Query: 295 ---------------CKG------DLVGPACGVLRNLVGV--EEVK-------------- 317
C+G + PA VL LV EEV
Sbjct: 217 KLSMLRNATWTLSNFCRGKPPPAFEQTQPALPVLERLVQSMDEEVLTDACWALSYLSDNS 276
Query: 318 ----RFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLR 373
+ ++E V I+L+ ++ + ++ I NI GD+L QMV+ + + LL
Sbjct: 277 NDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQTQMVLDQQALPCLLN 336
Query: 374 VLDPKWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSI-QELAL 432
+L K +Y K+ I ++ ++ + ++ G + L++ ++ E + +E A
Sbjct: 337 LL--KNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQSAEFEVKKEAAW 394
Query: 433 KVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVTVPRNRKRFVQ 492
++ SG + + K M G + L +V + EAL ++ V K
Sbjct: 395 GISNATSGGTHDQIKFMVSQGCIKPLCDLLTCPDLKVVTVCLEALENILVVGEAEKNLGH 454
Query: 493 DDHNIALLLQLLDPEEG 509
+ L Q++D EG
Sbjct: 455 TGED-NLYAQMIDEAEG 470
>VAC8_YEAST (P39968) Vacuolar protein 8
Length = 578
Score = 53.1 bits (126), Expect = 2e-06
Identities = 73/329 (22%), Positives = 142/329 (42%), Gaps = 24/329 (7%)
Query: 237 ISAGVIAPLIRVLDCGSELGKVAAARCLMKLTENSDNAWAVSAHGGVTALLNICGNDDCK 296
+S V+ P++ +L +VAA L L N++N + GG+ L+N D+
Sbjct: 82 VSREVLEPILILLQSQDPQIQVAACAALGNLAVNNENKLLIVEMGGLEPLINQMMGDNV- 140
Query: 297 GDLVGPACGVLRNLVGVEEVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDE 356
++ A G + NL ++ K + A+ +L KSK +Q N+ G + N+ +E
Sbjct: 141 -EVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSKHIRVQRNATGALLNMTHSEE 199
Query: 357 LVRQMVIREGGIRALLRVL---DPKWSYSSKTKEITMRAIES----LCFTSSSSVSILMS 409
R+ ++ G + L+ +L DP Y T + E+ L T VS L+S
Sbjct: 200 -NRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLAQTEPRLVSKLVS 258
Query: 410 YGFVDQLLYYVR-HGEVSIQELALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFE 468
+D V+ ++++ LA +++L + AG + VK + + S
Sbjct: 259 --LMDSPSSRVKCQATLALRNLASDTSYQLE---------IVRAGGLPHLVKLIQSDSIP 307
Query: 469 VREMAAEALSGMVTVPRNRKRFVQDDHNIALLLQLLDPEEGNSGNKKFLISILMSLTSCN 528
+ +A+ A +++ + + D + L++LLD ++ + ++ S
Sbjct: 308 L-VLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRNLAASSE 366
Query: 529 SARKKIVSSGYAKNIDKLA-DAEVSCDAK 556
RK+ SG + +LA D+ VS ++
Sbjct: 367 KNRKEFFESGAVEKCKELALDSPVSVQSE 395
>IMA4_MOUSE (O35343) Importin alpha-4 subunit (Karyopherin alpha-4
subunit) (Importin alpha Q1)
Length = 521
Score = 46.6 bits (109), Expect = 2e-04
Identities = 52/232 (22%), Positives = 95/232 (40%), Gaps = 5/232 (2%)
Query: 252 GSELGKVAAARCLMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLV 311
G +L V AAR L+ N + + G+ +L C D L A L N+
Sbjct: 86 GIQLSAVQAARKLLSSDRNPPIDDLIKS--GILPILVHCLERDDNPSLQFEAAWALTNIA 143
Query: 312 -GVEEVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRA 370
G E + +V+ +AV F+RL+ S + + ++ + NI R VI G ++
Sbjct: 144 SGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKP 203
Query: 371 LLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQEL 430
LL + P + + +T + +LC + + L + H +V+I
Sbjct: 204 LLSFISPSIPITF-LRNVTWVMV-NLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVD 261
Query: 431 ALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVT 482
+ L+ E + + D+G + V L+ + +V+ A A+ +VT
Sbjct: 262 TVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVT 313
>IMA4_HUMAN (O00629) Importin alpha-4 subunit (Karyopherin alpha-4
subunit) (Qip1 protein)
Length = 521
Score = 46.6 bits (109), Expect = 2e-04
Identities = 52/232 (22%), Positives = 95/232 (40%), Gaps = 5/232 (2%)
Query: 252 GSELGKVAAARCLMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLV 311
G +L V AAR L+ N + + G+ +L C D L A L N+
Sbjct: 86 GIQLSAVQAARKLLSSDRNPPIDDLIKS--GILPILVHCLERDDNPSLQFEAAWALTNIA 143
Query: 312 -GVEEVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRA 370
G E + +V+ +AV F+RL+ S + + ++ + NI R VI G ++
Sbjct: 144 SGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKP 203
Query: 371 LLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQEL 430
LL + P + + +T + +LC + + L + H +V+I
Sbjct: 204 LLSFISPSIPITF-LRNVTWVMV-NLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVD 261
Query: 431 ALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVT 482
+ L+ E + + D+G + V L+ + +V+ A A+ +VT
Sbjct: 262 TVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVT 313
>CTNB_XENLA (P26233) Beta-catenin
Length = 781
Score = 46.6 bits (109), Expect = 2e-04
Identities = 57/255 (22%), Positives = 110/255 (42%), Gaps = 16/255 (6%)
Query: 231 SYKGVLISAGVIAPLIRVLDCGSELGKVAAARC----LMKLTENSDNAWAVSAHGGVTAL 286
S ++ S +++ ++R + ++ V ARC L L+ + + A+ GG+ AL
Sbjct: 184 SRHAIMRSPQMVSAIVRTMQNTND---VETARCTAGTLHNLSHHREGLLAIFKSGGIPAL 240
Query: 287 LNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMVE-EDAVSTFIRLVKSKEEAIQVNSI 345
+ + G+ ++ A L NL+ +E + V + + L+ +
Sbjct: 241 VKMLGSP--VDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITT 298
Query: 346 GFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVS 405
+Q +A+G++ + +++ GG +AL+ ++ +SY K T R ++ L SS+ +
Sbjct: 299 DCLQILAYGNQESKLIILASGGPQALVNIM-RTYSY-EKLLWTTSRVLKVLSVCSSNKPA 356
Query: 406 ILMSYGFVDQLLYYVRHGEVSIQELALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAK 465
I+ + G L H S Q L + L S+ A K G G + V+ L +
Sbjct: 357 IVEAGGMQALGL----HLTDSSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSD 412
Query: 466 SFEVREMAAEALSGM 480
V AA LS +
Sbjct: 413 DINVVTCAAGILSNL 427
>ARM_DROME (P18824) Armadillo segment polarity protein
Length = 843
Score = 45.4 bits (106), Expect = 4e-04
Identities = 62/300 (20%), Positives = 126/300 (41%), Gaps = 29/300 (9%)
Query: 204 LVGFLGSNEVEIQEESAKVVCVLAGFDSYK-GVLISAGVIAPLIRVLDCGSELGKV-AAA 261
L+ L + + ++A +V L+ ++ + ++ S ++A L+R + ++L AA
Sbjct: 164 LIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAV 223
Query: 262 RCLMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMV 321
L L+ + A+ GG+ AL+ + L P VL + + ++
Sbjct: 224 GTLHNLSHHRQGLLAIFKSGGIPALVKL---------LSSPVESVL--FYAITTLHNLLL 272
Query: 322 EEDAVSTFIRLVKSKEEAI---QVNSIGFI-------QNIAFGDELVRQMVIREGGIRAL 371
+D +RL ++ + Q N++ F+ Q +A+G++ + +++ GG L
Sbjct: 273 HQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNEL 332
Query: 372 LRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQELA 431
+R++ + Y K T R ++ L SS+ +I+ + G ++ G +S L
Sbjct: 333 VRIM-RSYDY-EKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHL---GNMS-PRLV 386
Query: 432 LKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVTVPRNRKRFV 491
+ L S+ A K G + V+ L + V AA LS + + K V
Sbjct: 387 QNCLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATV 446
>PLAK_BOVIN (Q8SPJ1) Junction plakoglobin (Desmoplakin III)
Length = 745
Score = 43.5 bits (101), Expect = 0.002
Identities = 61/307 (19%), Positives = 127/307 (40%), Gaps = 17/307 (5%)
Query: 204 LVGFLGSNEVEIQEESAKVVCVLAGFDSYKGVLI-SAGVIAPLIRVLDCGSELGKVAAAR 262
L L + + ++A +V L+ ++ + L+ S ++A ++R + S+L AR
Sbjct: 147 LTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLD---TAR 203
Query: 263 C----LMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLVGVEEVKR 318
C L L+ + + A+ GG+ AL+ + + ++ A L NL+ +E +
Sbjct: 204 CTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSP--VESVLFYAITTLHNLLLYQEGAK 261
Query: 319 FMVE-EDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDP 377
V D + + L+ + +Q +A+G++ + +++ GG +AL++++
Sbjct: 262 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIM-R 320
Query: 378 KWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQELALKVAFR 437
+SY K T R ++ L S+ +I+ + G + +H + L +
Sbjct: 321 NYSY-EKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNSPRLVQNCLWT 375
Query: 438 LSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVTVPRNRKRFVQDDHNI 497
L S+ A K G + V L+ V A LS + K V + +
Sbjct: 376 LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGV 435
Query: 498 ALLLQLL 504
L+ +
Sbjct: 436 EALIHAI 442
>PKP4_HUMAN (Q99569) Plakophilin 4 (p0071)
Length = 1211
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/142 (22%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 314 EEVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLR 373
++ + F + + I +++ + ++Q N+ ++Q++ FGD V+ V R GGI+ L+
Sbjct: 518 KDPREFAWRDPELPEVIHMLEHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577
Query: 374 VLDPKWSYSSKTKEITMRAIESLCFTSSSSVS--ILMSYGFVDQLLYYVRHG-EVSIQEL 430
+LD + + ++ A+ +L F S+ + + + G + LL +R + ++EL
Sbjct: 578 LLDHR---VLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVREL 634
Query: 431 ALKVAFRLSGTSEEAKKAMGDA 452
V + LS + DA
Sbjct: 635 VTGVLWNLSSCDAVKMTIIRDA 656
>CTNB_MOUSE (Q02248) Beta-catenin
Length = 781
Score = 43.5 bits (101), Expect = 0.002
Identities = 55/255 (21%), Positives = 109/255 (42%), Gaps = 16/255 (6%)
Query: 231 SYKGVLISAGVIAPLIRVLDCGSELGKVAAARC----LMKLTENSDNAWAVSAHGGVTAL 286
S ++ S +++ ++R + ++ V ARC L L+ + + A+ GG+ AL
Sbjct: 184 SRHAIMRSPQMVSAIVRTMQNTND---VETARCTAGTLHNLSHHREGLLAIFKSGGIPAL 240
Query: 287 LNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMVE-EDAVSTFIRLVKSKEEAIQVNSI 345
+ + G+ ++ A L NL+ +E + V + + L+ +
Sbjct: 241 VKMLGSP--VDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITT 298
Query: 346 GFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVS 405
+Q +A+G++ + +++ GG +AL+ ++ ++Y K T R ++ L SS+ +
Sbjct: 299 DCLQILAYGNQESKLIILASGGPQALVNIM-RTYTY-EKLLWTTSRVLKVLSVCSSNKPA 356
Query: 406 ILMSYGFVDQLLYYVRHGEVSIQELALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAK 465
I+ + G L H Q L + L S+ A K G G + V+ L +
Sbjct: 357 IVEAGGMQALGL----HLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSD 412
Query: 466 SFEVREMAAEALSGM 480
V AA LS +
Sbjct: 413 DINVVTCAAGILSNL 427
>CTNB_HUMAN (P35222) Beta-catenin (PRO2286)
Length = 781
Score = 43.5 bits (101), Expect = 0.002
Identities = 55/255 (21%), Positives = 109/255 (42%), Gaps = 16/255 (6%)
Query: 231 SYKGVLISAGVIAPLIRVLDCGSELGKVAAARC----LMKLTENSDNAWAVSAHGGVTAL 286
S ++ S +++ ++R + ++ V ARC L L+ + + A+ GG+ AL
Sbjct: 184 SRHAIMRSPQMVSAIVRTMQNTND---VETARCTAGTLHNLSHHREGLLAIFKSGGIPAL 240
Query: 287 LNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMVE-EDAVSTFIRLVKSKEEAIQVNSI 345
+ + G+ ++ A L NL+ +E + V + + L+ +
Sbjct: 241 VKMLGSP--VDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITT 298
Query: 346 GFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVS 405
+Q +A+G++ + +++ GG +AL+ ++ ++Y K T R ++ L SS+ +
Sbjct: 299 DCLQILAYGNQESKLIILASGGPQALVNIM-RTYTY-EKLLWTTSRVLKVLSVCSSNKPA 356
Query: 406 ILMSYGFVDQLLYYVRHGEVSIQELALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAK 465
I+ + G L H Q L + L S+ A K G G + V+ L +
Sbjct: 357 IVEAGGMQALGL----HLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSD 412
Query: 466 SFEVREMAAEALSGM 480
V AA LS +
Sbjct: 413 DINVVTCAAGILSNL 427
>IMA1_SCHPO (O14063) Importin alpha subunit (Karyopherin alpha
subunit) (Serine-rich RNA polymerase I suppressor
protein)
Length = 542
Score = 43.1 bits (100), Expect = 0.002
Identities = 48/243 (19%), Positives = 107/243 (43%), Gaps = 11/243 (4%)
Query: 194 VVDVSDVVHVLVGFLGSNEVEIQEESAKVVCVLAGFDSY-KGVLISAGVIAPLIRVLDCG 252
VV ++ V V V L S+E +++E++ + +AG + ++ GV+ PL+ +++
Sbjct: 158 VVVEANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCGVLEPLLNIIESN 217
Query: 253 SELGKVAAARCLMKLT---ENSDNAW-AVSAHGGVTALLNICGNDDCKGDLVGPACGVLR 308
L + + + +N W ++S V + L ++D D + A L
Sbjct: 218 RRLSMLRNSTWTLSNMCRGKNPQPDWNSISQVIPVLSKLIYTLDEDVLVDALW-AISYLS 276
Query: 309 NLVGVEEVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGI 368
+ G E + +++ + L+ +Q ++ + NI GD++ Q++I G +
Sbjct: 277 D--GANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVTGDDVQTQVIINCGAL 334
Query: 369 RALLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQ 428
ALL +L S ++ I ++ +SS + ++ + L++ + + IQ
Sbjct: 335 SALLSLLS---SPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQ 391
Query: 429 ELA 431
+ A
Sbjct: 392 KEA 394
>CTNB_RAT (Q9WU82) Beta-catenin
Length = 781
Score = 42.7 bits (99), Expect = 0.003
Identities = 54/255 (21%), Positives = 109/255 (42%), Gaps = 16/255 (6%)
Query: 231 SYKGVLISAGVIAPLIRVLDCGSELGKVAAARC----LMKLTENSDNAWAVSAHGGVTAL 286
S ++ S +++ ++R + ++ V ARC L L+ + + A+ GG+ AL
Sbjct: 184 SRHAIMRSPQMVSAIVRTMQNTND---VETARCTAGTLHNLSHHREGLLAIFKSGGIPAL 240
Query: 287 LNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMVE-EDAVSTFIRLVKSKEEAIQVNSI 345
+ + G+ ++ A L NL+ +E + V + + L+ +
Sbjct: 241 VKMLGSP--VDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITT 298
Query: 346 GFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVS 405
+Q +A+G++ + +++ GG +AL+ ++ ++Y K T R ++ L SS+ +
Sbjct: 299 DCLQILAYGNQESKLIILASGGPQALVNIM-RTYTY-EKLLWTTSRVLKVLSVCSSNKPA 356
Query: 406 ILMSYGFVDQLLYYVRHGEVSIQELALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAK 465
I+ + G + H Q L + L S+ A K G G + V+ L +
Sbjct: 357 IVEAGG----MQALGPHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSD 412
Query: 466 SFEVREMAAEALSGM 480
V AA LS +
Sbjct: 413 DINVVTCAAGILSNL 427
>PLAK_MOUSE (Q02257) Junction plakoglobin (Desmoplakin III)
(Fragment)
Length = 621
Score = 42.0 bits (97), Expect = 0.004
Identities = 60/307 (19%), Positives = 126/307 (40%), Gaps = 17/307 (5%)
Query: 204 LVGFLGSNEVEIQEESAKVVCVLAGFDSYKGVLI-SAGVIAPLIRVLDCGSELGKVAAAR 262
L L + + ++A +V L+ ++ + L+ S ++A ++R + S+L AR
Sbjct: 23 LTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLD---TAR 79
Query: 263 C----LMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLVGVEEVKR 318
C L L+ + + A+ GG+ AL+ + + ++ A L NL+ +E +
Sbjct: 80 CTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSP--VESVLFYAITTLHNLLLYQEGAK 137
Query: 319 FMVE-EDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDP 377
V D + + L+ + +Q +A+G++ + +++ GG + L++++
Sbjct: 138 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIM-R 196
Query: 378 KWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQELALKVAFR 437
+SY K T R ++ L S+ +I+ + G + +H + L +
Sbjct: 197 NYSY-EKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNSPRLVQNCLWT 251
Query: 438 LSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVTVPRNRKRFVQDDHNI 497
L S+ A K G + V L+ V A LS + K V + +
Sbjct: 252 LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGV 311
Query: 498 ALLLQLL 504
L+ +
Sbjct: 312 EALIHAI 318
>CTD2_MOUSE (O35927) Catenin delta-2 (Neural plakophilin-related
ARM-repeat protein) (NPRAP) (Neurojungin)
Length = 1247
Score = 42.0 bits (97), Expect = 0.004
Identities = 35/163 (21%), Positives = 78/163 (47%), Gaps = 13/163 (7%)
Query: 287 LNICGNDDCKGDLVGPAC---GVLRNLVGVEEVKR----FMVEEDAVSTFIRLVKSKEEA 339
L C + D GPA G L ++ +++ F + + I++++ + +
Sbjct: 503 LQYCASVDSPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPS 562
Query: 340 IQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCF- 398
+Q N+ ++Q++ FGD ++ + R+GGI+ L+ +LD + ++ A+ +L +
Sbjct: 563 VQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHR---MTEVHRSACGALRNLVYG 619
Query: 399 -TSSSSVSILMSYGFVDQLLYYVRH-GEVSIQELALKVAFRLS 439
+ + L + G + L+ +R ++ I+EL V + LS
Sbjct: 620 KANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLS 662
>PLAK_HUMAN (P14923) Junction plakoglobin (Desmoplakin III)
Length = 743
Score = 41.6 bits (96), Expect = 0.006
Identities = 59/306 (19%), Positives = 124/306 (40%), Gaps = 16/306 (5%)
Query: 204 LVGFLGSNEVEIQEESAKVVCVLAGFDSYKGVLI-SAGVIAPLIRVLDCGSELGKVAAAR 262
L L + + ++A +V L+ ++ + L+ S ++A ++R + S+L AR
Sbjct: 146 LTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLD---TAR 202
Query: 263 C----LMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLVGVEEVKR 318
C L L+ + + A+ GG+ AL+ + + ++ A L NL+ +E +
Sbjct: 203 CTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSP--VESVLFYAITTLHNLLLYQEGAK 260
Query: 319 FMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDPK 378
+ L+ + +Q +A+G++ + +++ GG +AL++++
Sbjct: 261 MACAGRRAQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIM-RN 319
Query: 379 WSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQELALKVAFRL 438
+SY K T R ++ L S+ +I+ + G + +H + L + L
Sbjct: 320 YSY-EKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNSPRLVQNCLWTL 374
Query: 439 SGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVTVPRNRKRFVQDDHNIA 498
S+ A K G + V L+ V A LS + K V + +
Sbjct: 375 RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVE 434
Query: 499 LLLQLL 504
L+ +
Sbjct: 435 ALIHAI 440
>ARM_MUSDO (Q02453) Armadillo segment polarity protein
Length = 813
Score = 41.6 bits (96), Expect = 0.006
Identities = 61/300 (20%), Positives = 122/300 (40%), Gaps = 29/300 (9%)
Query: 204 LVGFLGSNEVEIQEESAKVVCVLAGFDSYKGVLI-SAGVIAPLIRVLDCGSELGKV-AAA 261
L+ L + + ++A +V L+ ++ + + S ++A L+R + ++L AA
Sbjct: 154 LIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAITNSPQMVAALVRAISNSNDLESTKAAV 213
Query: 262 RCLMKLTENSDNAWAVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMV 321
L L+ + A+ GG+ AL+ + L P VL + + ++
Sbjct: 214 GTLHNLSHHRQGLLAIFKSGGIPALVKL---------LSSPVESVL--FYAITTLHNLLL 262
Query: 322 EEDAVSTFIRLVKSKEEAI---QVNSIGFI-------QNIAFGDELVRQMVIREGGIRAL 371
+D +RL ++ + Q N++ F+ Q +A+G++ + +++ GG L
Sbjct: 263 HQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNEL 322
Query: 372 LRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQELA 431
+R++ + Y K T R ++ L SS+ +I+ + G + H L
Sbjct: 323 VRIM-RSYDY-EKLLWTTSRVLKVLSVCSSNKPAIVDAGG----MQALAMHLSNPSPRLV 376
Query: 432 LKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMVTVPRNRKRFV 491
+ L S+ A K G + V+ L + V AA LS + + K V
Sbjct: 377 QNCLWTLRNLSDAATKVDGLEPLLQSLVQVLASTDVNVVTCAAGILSNLTCNNQRNKATV 436
>PKP1_HUMAN (Q13835) Plakophilin 1 (Band-6-protein) (B6P)
Length = 747
Score = 40.4 bits (93), Expect = 0.013
Identities = 31/124 (25%), Positives = 59/124 (47%), Gaps = 4/124 (3%)
Query: 330 IRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEIT 389
++ + S++E Q +IQ+ F DE +Q V + GGI L+ +L S + ++
Sbjct: 251 VQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLR---SPNQNVQQAA 307
Query: 390 MRAIESLCFTSSSS-VSILMSYGFVDQLLYYVRHGEVSIQELALKVAFRLSGTSEEAKKA 448
A+ +L F S+++ + G + + R G IQ+ + + LS T E ++
Sbjct: 308 AGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEEL 367
Query: 449 MGDA 452
+ DA
Sbjct: 368 IADA 371
>IMA_LYCES (O22478) Importin alpha subunit (Karyopherin alpha
subunit) (KAP alpha)
Length = 527
Score = 40.4 bits (93), Expect = 0.013
Identities = 64/286 (22%), Positives = 122/286 (42%), Gaps = 10/286 (3%)
Query: 198 SDVVHVLVGFLGSNEV-EIQEESAKVVCVLA-GFDSYKGVLISAGVIAPLIRVLDCGSEL 255
S VV V FL ++ ++Q E+A + +A G V+I G + IR+L S+
Sbjct: 115 SGVVPRFVEFLARDDYPQLQFEAAWALTNIASGTSENTKVVIDYGSVPIFIRLLSSPSDD 174
Query: 256 GKVAAARCLMKLTENSDNAW-AVSAHGGVTALLNICGNDDCKGDLVGPACGVLRNLVGVE 314
+ A L + +S V HG + ALL N+ K ++ A L N +
Sbjct: 175 VREQAVWALGNIAGDSPKYRDLVLGHGALVALLAQF-NEQAKLSMLRNATWTLSNFCRGK 233
Query: 315 EVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRV 374
F + A+ T RL+ S +E + ++ + ++ G Q VI G L+ +
Sbjct: 234 PQPLFEQTKAALPTLGRLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCSRLVEL 293
Query: 375 LDPKWSYSSKTKEI-TMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHG-EVSIQELAL 432
L +SS + I +R + ++ +++ + + L+ + + SI++ A
Sbjct: 294 L----LHSSPSVLIPALRTVGNIVTGDDIQTQVMIDHHALPCLVNLLTQNYKKSIKKEAC 349
Query: 433 KVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALS 478
++ + + + +AG + V L FE+++ AA A+S
Sbjct: 350 WTISNITAGNRNQIQIVIEAGIIAPLVYLLQNAEFEIKKEAAWAIS 395
Score = 33.5 bits (75), Expect = 1.6
Identities = 40/189 (21%), Positives = 84/189 (44%), Gaps = 8/189 (4%)
Query: 175 ALRNLLEVVVEDEKYVKVIVVDVSDVVHVLVGFLGSN-EVEIQEESAKVVC-VLAGFDSY 232
ALR + +V D+ +V++ + LV L N + I++E+ + + AG +
Sbjct: 305 ALRTVGNIVTGDDIQTQVMIDH--HALPCLVNLLTQNYKKSIKKEACWTISNITAGNRNQ 362
Query: 233 KGVLISAGVIAPLIRVLDCGSELGKVAAARCLMKLTE--NSDNAWAVSAHGGVTALLNIC 290
++I AG+IAPL+ +L K AA + T N D + + G + L ++
Sbjct: 363 IQIVIEAGIIAPLVYLLQNAEFEIKKEAAWAISNATSGGNHDQIKFLVSQGCIKPLCDLL 422
Query: 291 GNDDCKGDLVGPACGVLRNLVGVEEVKRFMVEEDAVSTFIRLVKSKEEAIQVNSIGFIQN 350
D + +V L N++ + E + + + V+ + +L+ E ++ ++ N
Sbjct: 423 VCPDPR--IVTVCLEGLENILKIGEADKDLGNTEGVNVYAQLIDEAEGLEKIENLQSHDN 480
Query: 351 IAFGDELVR 359
++ V+
Sbjct: 481 TEIYEKAVK 489
Score = 32.3 bits (72), Expect = 3.5
Identities = 42/179 (23%), Positives = 78/179 (43%), Gaps = 11/179 (6%)
Query: 330 IRLVKSKEEAIQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTK-EI 388
IR K +E ++ G +Q F + ++ + L ++ WS S + E
Sbjct: 36 IRKNKREENLLKKRREGLLQAQQFPSTAAVSHLDKK--LETLPELIAGVWSDDSSLQLEC 93
Query: 389 TMRAIESLCFTSSSSVSILMSYGFVDQLLYYVRHGEVSIQELALKVAFRL----SGTSEE 444
T + + L + + ++ G V + + ++ + +L + A+ L SGTSE
Sbjct: 94 TTQFRKLLSIERNPPIEEVIQSGVVPRFVEFLARDDYP--QLQFEAAWALTNIASGTSEN 151
Query: 445 AKKAMGDAGFMVEFVKFLNAKSFEVREMAAEALSGMV-TVPRNRKRFVQDDHNIALLLQ 502
K + D G + F++ L++ S +VRE A AL + P+ R + +ALL Q
Sbjct: 152 TKVVI-DYGSVPIFIRLLSSPSDDVREQAVWALGNIAGDSPKYRDLVLGHGALVALLAQ 209
>PLAK_XENLA (P30998) Junction plakoglobin (Desmoplakin III)
Length = 738
Score = 40.0 bits (92), Expect = 0.017
Identities = 53/279 (18%), Positives = 115/279 (40%), Gaps = 16/279 (5%)
Query: 231 SYKGVLISAGVIAPLIRVLDCGSELGKVAAARC----LMKLTENSDNAWAVSAHGGVTAL 286
S K ++ S ++A ++R + S++ ARC L L+ + + ++ GG+ AL
Sbjct: 171 SRKALMQSPQIVAAIVRTMQHTSDMD---TARCTTSILHNLSHHREGLLSIFKSGGIPAL 227
Query: 287 LNICGNDDCKGDLVGPACGVLRNLVGVEEVKRFMVE-EDAVSTFIRLVKSKEEAIQVNSI 345
+ + + ++ A L NL+ +E + V D + + L+ +
Sbjct: 228 VRMLSSP--VESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITT 285
Query: 346 GFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCFTSSSSVS 405
+Q +A+G++ + +++ GG + L++++ ++Y K T R ++ L S+ +
Sbjct: 286 DCLQLLAYGNQESKLIILGNGGPQGLVQIM-RNYNY-EKLLWTTSRVLKVLSVCPSNKPA 343
Query: 406 ILMSYGFVDQLLYYVRHGEVSIQELALKVAFRLSGTSEEAKKAMGDAGFMVEFVKFLNAK 465
I+ + G + +H + L + L S+ A K G + V L++
Sbjct: 344 IVEAGG----MQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLDNVLKILVNQLSSD 399
Query: 466 SFEVREMAAEALSGMVTVPRNRKRFVQDDHNIALLLQLL 504
V A LS + K V + + L+ +
Sbjct: 400 DVNVLTCATGTLSNLTCNNGRNKTLVTQSNGVESLIHTI 438
>CTD2_HUMAN (Q9UQB3) Catenin delta-2 (Delta-catenin) (Neural
plakophilin-related ARM-repeat protein) (NPRAP)
(Neurojungin) (GT24)
Length = 1225
Score = 39.7 bits (91), Expect = 0.022
Identities = 34/163 (20%), Positives = 78/163 (46%), Gaps = 13/163 (7%)
Query: 287 LNICGNDDCKGDLVGPAC---GVLRNLVGVEEVKR----FMVEEDAVSTFIRLVKSKEEA 339
L C + + GPA G L ++ +++ F + + I++++ + +
Sbjct: 506 LQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPS 565
Query: 340 IQVNSIGFIQNIAFGDELVRQMVIREGGIRALLRVLDPKWSYSSKTKEITMRAIESLCF- 398
+Q N+ ++Q++ FGD ++ + R+GGI+ L+ +LD + ++ A+ +L +
Sbjct: 566 VQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHR---MTEVHRSACGALRNLVYG 622
Query: 399 -TSSSSVSILMSYGFVDQLLYYVRH-GEVSIQELALKVAFRLS 439
+ + L + G + L+ +R ++ I+EL V + LS
Sbjct: 623 KANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLS 665
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.320 0.136 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,914,372
Number of Sequences: 164201
Number of extensions: 2318603
Number of successful extensions: 6355
Number of sequences better than 10.0: 40
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 6312
Number of HSP's gapped (non-prelim): 78
length of query: 577
length of database: 59,974,054
effective HSP length: 116
effective length of query: 461
effective length of database: 40,926,738
effective search space: 18867226218
effective search space used: 18867226218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Medicago: description of AC146792.2