BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146692.2 - phase: 0
(1061 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
HER3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3 159 3e-38
RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat... 137 2e-31
RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator 134 1e-30
CEBP_HUMAN (Q9UII4) Cyclin-E binding protein 1 132 4e-30
RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator 132 6e-30
NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7... 126 4e-28
NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7... 125 6e-28
NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7... 121 9e-27
NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7... 116 4e-25
NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7... 114 1e-24
NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7... 114 2e-24
RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma... 109 3e-23
RCC1_SCHPO (P28745) Pim1 protein (Poly(A)+ RNA transport protein 2) 107 2e-22
GNFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related p... 105 8e-22
GNFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related p... 103 2e-21
RCC1_HUMAN (P18754) Regulator of chromosome condensation (Cell c... 98 1e-19
RCC1_MESAU (P23800) Regulator of chromosome condensation 95 1e-18
RCC1_XENLA (P25183) Regulator of chromosome condensation 91 2e-17
WS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 1... 87 2e-16
WS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 1... 81 1e-14
>HER3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3
Length = 1050
Score = 159 bits (403), Expect = 3e-38
Identities = 112/361 (31%), Positives = 186/361 (51%), Gaps = 23/361 (6%)
Query: 271 VQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGE 330
V+ +ACGG H+ + + GE+++ G + G+LGH + + P+ I AL++ +I VACGE
Sbjct: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADQHIIHVACGE 93
Query: 331 YHTCAVTLSGDLYTWGNGA-YNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTA 389
H+ A++ G L++WG G+ GL+ + V+ VP+ + L + +SCG WH
Sbjct: 94 SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVA--VPRLIQ-KLNQQTILQVSCGNWHCL 150
Query: 390 VVTSAGQLFTFGDGTFGALGHG-DRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMV 448
+ + GQ FT+G + G LG G + S + P+ V SL+G+ + + G H+ A+
Sbjct: 151 ALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL----- 205
Query: 449 GNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVE-HNFCQVACGHSLTVALT 507
SG +F WG + G+LG D++ + P V L+ ++CG T LT
Sbjct: 206 -------SLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLT 258
Query: 508 TSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSFVEEIACGAYH-VAVLTLRNEVYT 566
SG V+ G+ GQLG+ + ++ R +L+ S V +IACG H +A + +Y
Sbjct: 259 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYA 318
Query: 567 WGKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIACGTNFTAAICLHKWVSGVDQS--MC 624
+G GA G+LG G T + P+ V H ++ + + + SG DQ+ +C
Sbjct: 319 FGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLC 378
Query: 625 S 625
S
Sbjct: 379 S 379
Score = 147 bits (372), Expect = 1e-34
Identities = 109/324 (33%), Positives = 166/324 (50%), Gaps = 26/324 (8%)
Query: 293 WGEESGGRLGHGVDSD--VLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAY 350
WG S G+ G + V P++ +S+ +++ VACG H+ + G++YT G
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 351 NYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALG- 409
G LGH + + P+++ G L H+ +++CG H+ ++ GQLF++G G+ G LG
Sbjct: 64 --GQLGHEREGNK--PEQI-GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118
Query: 410 HGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDK 469
SV++PR ++ L ++ SCG WH A+ + G+ FTWG
Sbjct: 119 MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALA------------ADGQFFTWGKNSH 166
Query: 470 GRLGHGDK-EAKLVPTCVALVEH-NFCQVACGHSLTVALTTSGHVYAMGSPVYGQLG-NP 526
G+LG G + ++ P V +E QVA G + + AL+ SG V+ G GQLG +
Sbjct: 167 GQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSD 226
Query: 527 QADGKLPTRVEGKLLKSF-VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNN 585
+ D + P V KLL++ V I+CG H AVLT V+T+G G+ G+LGH +D N
Sbjct: 227 EKDRESPCHV--KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVN 284
Query: 586 PTLVDALKDKHVKSIACGTNFTAA 609
P V L V IACG T A
Sbjct: 285 PRRVLELMGSEVTQIACGRQHTLA 308
Score = 138 bits (347), Expect = 9e-32
Identities = 95/293 (32%), Positives = 150/293 (50%), Gaps = 20/293 (6%)
Query: 251 LGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSD-V 309
LG + + P+ + + + ++ACG H+ ++ +G++FSWG S G+LG D V
Sbjct: 66 LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSV 125
Query: 310 LHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQV-SHWVPKR 368
P+LI L+ I V+CG +H A+ G +TWG ++G LG G + S P+R
Sbjct: 126 AVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKN--SHGQLGLGKEFPSQASPQR 183
Query: 369 VNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGL 428
V LEGI ++ ++ G H+ ++ +G +F +G G LG D K P V+ L+
Sbjct: 184 VRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ 242
Query: 429 RTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCV-A 487
+ + SCG HTA + + SG +FT+G G G+LGH ++ P V
Sbjct: 243 KVVYISCGEEHTAVLTK------------SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLE 290
Query: 488 LVEHNFCQVACGHSLTVA-LTTSGHVYAMGSPVYGQLGNPQ-ADGKLPTRVEG 538
L+ Q+ACG T+A + +SG +YA G GQLG + K P+ V+G
Sbjct: 291 LMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
Score = 120 bits (302), Expect = 1e-26
Identities = 84/252 (33%), Positives = 122/252 (48%), Gaps = 26/252 (10%)
Query: 226 GDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSL-FPKALESAVVLDVQNIACGGRHAALV 284
G +F WG G+ DG +G L DS+ P+ ++ + ++CG H +
Sbjct: 103 GQLFSWGAGS-DGQLG---------LMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLAL 152
Query: 285 TKQGEIFSWGEESGGRLGHGVD-SDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLY 343
G+ F+WG+ S G+LG G + P+ + +L + VA G H+ A++LSG ++
Sbjct: 153 AADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVF 212
Query: 344 TWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDG 403
WG N G LG ++ P V L V YISCG HTAV+T +G +FTFG G
Sbjct: 213 GWGMN--NAGQLGLSDEKDRESPCHVK-LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAG 269
Query: 404 TFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFT 463
+ G LGH PR V L G + +CG HT A V SSG ++
Sbjct: 270 SCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVP-----------SSGLIYA 318
Query: 464 WGDGDKGRLGHG 475
+G G +G+LG G
Sbjct: 319 FGCGARGQLGTG 330
Score = 101 bits (251), Expect = 1e-20
Identities = 70/249 (28%), Positives = 118/249 (47%), Gaps = 23/249 (9%)
Query: 368 RVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKG 427
+V G + V ++CG H+ + G+++T G T G LGH + + P ++ +L
Sbjct: 26 QVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGALAD 83
Query: 428 LRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKL-VPTCV 486
+ +CG H+ A+ + G+LF+WG G G+LG E + VP +
Sbjct: 84 QHIIHVACGESHSLALSD------------RGQLFSWGAGSDGQLGLMTTEDSVAVPRLI 131
Query: 487 A-LVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSF- 544
L + QV+CG+ +AL G + G +GQLG + + P++ + ++S
Sbjct: 132 QKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGK---EFPSQASPQRVRSLE 188
Query: 545 ---VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIA 601
+ ++A G H L+L V+ WG G+LG D DR +P V L+ + V I+
Sbjct: 189 GIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYIS 248
Query: 602 CGTNFTAAI 610
CG TA +
Sbjct: 249 CGEEHTAVL 257
>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator
(mRpgr)
Length = 1001
Score = 137 bits (345), Expect = 2e-31
Identities = 104/339 (30%), Positives = 164/339 (47%), Gaps = 30/339 (8%)
Query: 274 IACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHT 333
++CG H A+VT +++ +G + G+LG G + ++ P I AL ++L ACG HT
Sbjct: 40 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 99
Query: 334 CAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTS 393
T +G +Y G N G LG G+ ++ + +S G +A +T
Sbjct: 100 LVSTDTGGVYAAGGN--NEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTE 157
Query: 394 AGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSS 453
G+LF +GD + G +G D+ +V +P EV K + + SCG +H+A V
Sbjct: 158 DGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKPISWI--SCGYYHSAFVT--------- 206
Query: 454 SNCSSGKLFTWGDGDKGRLGHGDK--EAKLVPTCVALVEHNFCQVACGHSLTVALTTSGH 511
G+L+T+G+ + G+LG ++ P V + QVACG TV LT
Sbjct: 207 ---MDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEK-V 262
Query: 512 VYAMGSPVYGQLG-----NPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEVYT 566
VYA G +GQLG ++ K+ R++ + + I+CG H A++T +YT
Sbjct: 263 VYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQK----ICHISCGENHTALMTELGLLYT 318
Query: 567 WGKGANGRLGHGDTDDRNN--PTLVDALKDKHVKSIACG 603
+G G +G+LG G + N PTL V+ IACG
Sbjct: 319 FGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACG 357
Score = 121 bits (303), Expect = 1e-26
Identities = 90/288 (31%), Positives = 138/288 (47%), Gaps = 24/288 (8%)
Query: 326 VACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGP 385
++CG+ HT VT + LY +G+ N+G LG G++ + P + L+ V +CG
Sbjct: 40 LSCGDEHTAIVTGNNKLYMFGSN--NWGQLGLGSKAAIIKPTCIKA-LKPEKVKLAACGR 96
Query: 386 WHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRA-SCGVWHTAAVV 444
HT V T G ++ G G LG GD ++ T++ S G +AA+
Sbjct: 97 NHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALT 156
Query: 445 EVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQVACGHSLTV 504
E GKLF WGD +G++G DK +P V V ++CG+ +
Sbjct: 157 E------------DGKLFMWGDNSEGQIGLEDKSNVCIPHEVT-VGKPISWISCGYYHSA 203
Query: 505 ALTTSGHVYAMGSPVYGQLGNPQA---DGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLR 561
+T G +Y G P G+LG P + + P RV G + V ++ACG H VLT
Sbjct: 204 FVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLG--IPERVIQVACGGGHTVVLT-E 260
Query: 562 NEVYTWGKGANGRLGHGD-TDDRNNPTLVDALKDKHVKSIACGTNFTA 608
VY +G G G+LG G + + P +++ +KD+ + I+CG N TA
Sbjct: 261 KVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTA 308
Score = 108 bits (269), Expect = 1e-22
Identities = 89/327 (27%), Positives = 155/327 (47%), Gaps = 34/327 (10%)
Query: 242 GGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRL 301
G N+ GLG K + P +++ V+ ACG H + T G +++ G + G+L
Sbjct: 60 GSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQL 119
Query: 302 GHG--VDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGN 359
G G D D H + ++T I+ ++ G + A+T G L+ WG+ + G +G +
Sbjct: 120 GLGDTDDRDTFHQIVFFTPADT-IKQLSAGANTSAALTEDGKLFMWGDN--SEGQIGLED 176
Query: 360 QVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLP 419
+ + +P V G +S+ISCG +H+A VT G+L+TFG+ G LG + ++
Sbjct: 177 KSNVCIPHEVT---VGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMN-H 232
Query: 420 REVESLKGL--RTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHG-- 475
R + + G+ R ++ +CG HT + E +V + +G G G+LG G
Sbjct: 233 RSPQRVLGIPERVIQVACGGGHTVVLTEKVV-------------YAFGLGQFGQLGLGTF 279
Query: 476 ---DKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQAD--G 530
E K++ + + C ++CG + T +T G +Y G +G+LG +
Sbjct: 280 LFETSEPKIIE---RIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTN 336
Query: 531 KLPTRVEGKLLKSFVEEIACGAYHVAV 557
+ + L+ V+ IACG H+ V
Sbjct: 337 QFFPTLCSNFLRFAVQLIACGGCHMLV 363
>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator
Length = 1020
Score = 134 bits (338), Expect = 1e-30
Identities = 101/339 (29%), Positives = 166/339 (48%), Gaps = 28/339 (8%)
Query: 273 NIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYH 332
+++CG H+A+VT +++ +G + G+LG G S + P + AL ++L ACG H
Sbjct: 39 HLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNH 98
Query: 333 TCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVT 392
T T G++Y G N G LG G+ ++ + +S G +A +T
Sbjct: 99 TLVSTEGGNVY--ATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Query: 393 SAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSS 452
G+LF +GD + G +G + +V +P++V K + + SCG +H+A V
Sbjct: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWI--SCGYYHSAFVT-------- 206
Query: 453 SSNCSSGKLFTWGDGDKGRLGHGDK--EAKLVPTCVALVEHNFCQVACGHSLTVALTTSG 510
+ G+L+ +G+ + G+LG ++ P V+ + QVACG TV LT +
Sbjct: 207 ----TDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA 262
Query: 511 HVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSF----VEEIACGAYHVAVLTLRNEVYT 566
VY G +GQLG L E K++++ + I+CG H A++T +YT
Sbjct: 263 -VYTFGLGQFGQLG---LGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYT 318
Query: 567 WGKGANGRLGHGDTDDRNN--PTLVDALKDKHVKSIACG 603
+G G +G+LG G + N+ PTL VK +ACG
Sbjct: 319 FGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
Score = 117 bits (294), Expect = 1e-25
Identities = 87/288 (30%), Positives = 139/288 (48%), Gaps = 20/288 (6%)
Query: 326 VACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGP 385
++CG+ H+ VT + LY +G+ N+G LG G++ + P V L+ V +CG
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSN--NWGQLGLGSKSAISKPTCVKA-LKPEKVKLAACGR 96
Query: 386 WHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRA-SCGVWHTAAVV 444
HT V T G ++ G G LG GD + + + ++ S G
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAG-------- 148
Query: 445 EVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQVACGHSLTV 504
N+S++ G+LF WGD +G++G + VP V + + ++CG+ +
Sbjct: 149 ----SNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-VSWISCGYYHSA 203
Query: 505 ALTTSGHVYAMGSPVYGQLGNP-QADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNE 563
+TT G +Y G P G+LG P Q G T + V ++ACG H VLT N
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENA 262
Query: 564 VYTWGKGANGRLGHGD-TDDRNNPTLVDALKDKHVKSIACGTNFTAAI 610
VYT+G G G+LG G + + P +++ ++D+ + I+CG N TA I
Sbjct: 263 VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALI 310
Score = 101 bits (252), Expect = 9e-21
Identities = 89/330 (26%), Positives = 153/330 (45%), Gaps = 40/330 (12%)
Query: 242 GGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRL 301
G N+ GLG K P +++ V+ ACG H + T+ G +++ G + G+L
Sbjct: 60 GSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQL 119
Query: 302 GHGVDSDVLHPKLIDAL-SNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQ 360
G G + +I S I+ ++ G + A+T G L+ WG+ + G +G N
Sbjct: 120 GLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDN--SEGQIGLKNV 177
Query: 361 VSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALG-----HGDRKS 415
+ VP++V G VS+ISCG +H+A VT+ G+L+ FG+ G LG G+ ++
Sbjct: 178 SNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT 234
Query: 416 VSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHG 475
L E+ + ++ +CG HT + E ++T+G G G+LG G
Sbjct: 235 PQLVSEIPE----KVIQVACGGEHTVVLTE-------------NAVYTFGLGQFGQLGLG 277
Query: 476 -----DKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLG---NPQ 527
E K++ + + ++CG + T +T G +Y G +G+LG
Sbjct: 278 TFLFETSEPKVIEN---IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF 334
Query: 528 ADGKLPTRVEGKLLKSFVEEIACGAYHVAV 557
+ +PT + L+ V+ +ACG H+ V
Sbjct: 335 TNHFIPT-LCSNFLRFIVKLVACGGCHMVV 363
>CEBP_HUMAN (Q9UII4) Cyclin-E binding protein 1
Length = 1024
Score = 132 bits (333), Expect = 4e-30
Identities = 73/211 (34%), Positives = 116/211 (54%), Gaps = 15/211 (7%)
Query: 274 IACGGRHAALVTKQGEIFSWGEESGGRLGHGVD-SDVLHPKLIDALSNTNIELVACGEYH 332
I CG H+ ++K GE+F+WG+ G+LG G P++++ L+ + ++ GE H
Sbjct: 143 ITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAH 202
Query: 333 TCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVT 392
+ A+++SG++Y+WG G LG G+ S P + G L+ V +++CG H+A++T
Sbjct: 203 SMALSMSGNIYSWGKN--ECGQLGLGHTESKDDPSLIEG-LDNQKVEFVACGGSHSALLT 259
Query: 393 SAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSS 452
G LFTFG G G LGH ++ P V L G R + +CG WHT A V +
Sbjct: 260 QDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDL----- 314
Query: 453 SSNCSSGKLFTWGDGDKGRLGHGDKEAKLVP 483
GK+F++G G G+LG+G +L+P
Sbjct: 315 ------GKVFSFGSGKDGQLGNGGTRDQLMP 339
Score = 115 bits (287), Expect = 8e-25
Identities = 78/286 (27%), Positives = 132/286 (45%), Gaps = 35/286 (12%)
Query: 250 GLGVKIDSLF--------PKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRL 301
G GV++ L PK ++ + + ++ G H +++ G+ F + S
Sbjct: 70 GAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYS---- 125
Query: 302 GHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQV 361
+ H + L I + CG+YH+ A++ G+L+ WG +G LG G +
Sbjct: 126 -------MKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNL--HGQLGVGRKF 176
Query: 362 SHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPRE 421
++ L G+ ++ IS G H+ ++ +G ++++G G LG G +S P
Sbjct: 177 PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSL 236
Query: 422 VESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKL 481
+E L + +CG H+A + + G LFT+G G G+LGH + +L
Sbjct: 237 IEGLDNQKVEFVACGGSHSALLTQ------------DGLLFTFGAGKHGQLGHNSTQNEL 284
Query: 482 VPTCVA-LVEHNFCQVACGHSLTVALTTS-GHVYAMGSPVYGQLGN 525
P VA LV + Q+ACG T+A + G V++ GS GQLGN
Sbjct: 285 RPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGN 330
Score = 110 bits (275), Expect = 2e-23
Identities = 79/290 (27%), Positives = 138/290 (47%), Gaps = 29/290 (10%)
Query: 312 PKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNG 371
PK I N I V G H ++ G + + N + + R
Sbjct: 88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKH--------------LRFES 133
Query: 372 PLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDR-KSVSLPREVESLKGLRT 430
L+ + I+CG +H+ ++ G+LF +G G LG G + S + P+ VE L G+
Sbjct: 134 ILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPL 193
Query: 431 MRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVE 490
+ S G H+ A+ SG +++WG + G+LG G E+K P+ + ++
Sbjct: 194 AQISAGEAHSMAL------------SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLD 241
Query: 491 HNFCQ-VACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSFVEEIA 549
+ + VACG S + LT G ++ G+ +GQLG+ +L + +L+ V +IA
Sbjct: 242 NQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIA 301
Query: 550 CGAYH-VAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHVK 598
CG +H +A ++ +V+++G G +G+LG+G T D+ P V + +K
Sbjct: 302 CGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELK 351
Score = 108 bits (271), Expect = 6e-23
Identities = 75/233 (32%), Positives = 115/233 (49%), Gaps = 23/233 (9%)
Query: 226 GDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSLF-PKALESAVVLDVQNIACGGRHAALV 284
G++F WG+ N G+G K S P+ +E + + I+ G H+ +
Sbjct: 157 GELFAWGQ----------NLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206
Query: 285 TKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYT 344
+ G I+SWG+ G+LG G P LI+ L N +E VACG H+ +T G L+T
Sbjct: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFT 266
Query: 345 WGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHT-AVVTSAGQLFTFGDG 403
+G G +G LGH + + P V L G V+ I+CG WHT A V+ G++F+FG G
Sbjct: 267 FGAG--KHGQLGHNSTQNELRPCLV-AELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323
Query: 404 TFGALGHGDRKS--VSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSS 454
G LG+G + + LP +V S + L+ HT+ +M+ + S
Sbjct: 324 KDGQLGNGGTRDQLMPLPVKVSSSEELKLES------HTSEKELIMIAGGNQS 370
Score = 94.4 bits (233), Expect = 1e-18
Identities = 72/241 (29%), Positives = 114/241 (46%), Gaps = 31/241 (12%)
Query: 374 EGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRA 433
+ + + + G H +++S G+ F + D S+ R L+ + ++
Sbjct: 95 KNMKIHSVDQGAEHMLILSSDGKPFEY-----------DNYSMKHLRFESILQEKKIIQI 143
Query: 434 SCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEH-- 491
+CG +H+ A+ + G+LF WG G+LG G K T +VEH
Sbjct: 144 TCGDYHSLALSK------------GGELFAWGQNLHGQLGVGRKFPST--TTPQIVEHLA 189
Query: 492 --NFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKL-PTRVEGKLLKSFVEEI 548
Q++ G + ++AL+ SG++Y+ G GQLG + K P+ +EG L VE +
Sbjct: 190 GVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFV 248
Query: 549 ACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIACGTNFTA 608
ACG H A+LT ++T+G G +G+LGH T + P LV L V IACG T
Sbjct: 249 ACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTL 308
Query: 609 A 609
A
Sbjct: 309 A 309
Score = 75.5 bits (184), Expect = 7e-13
Identities = 37/127 (29%), Positives = 72/127 (56%), Gaps = 7/127 (5%)
Query: 488 LVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSF--- 544
L E Q+ CG ++AL+ G ++A G ++GQLG K P+ ++++
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLG---VGRKFPSTTTPQIVEHLAGV 191
Query: 545 -VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIACG 603
+ +I+ G H L++ +Y+WGK G+LG G T+ +++P+L++ L ++ V+ +ACG
Sbjct: 192 PLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACG 251
Query: 604 TNFTAAI 610
+ +A +
Sbjct: 252 GSHSALL 258
>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator
Length = 1003
Score = 132 bits (331), Expect = 6e-30
Identities = 100/336 (29%), Positives = 160/336 (46%), Gaps = 24/336 (7%)
Query: 274 IACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHT 333
++CG H A+VT +++ +G + G+LG G S V P + AL ++ ACG HT
Sbjct: 40 LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHT 99
Query: 334 CAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTS 393
T G +Y G N G LG G+ ++ + +S G +A +T
Sbjct: 100 LVSTEGGKVYAAGGN--NEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTE 157
Query: 394 AGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSS 453
G+LF +GD + G +G + +V +P++V K + + SCG +H+A V
Sbjct: 158 DGELFMWGDNSEGQIGLENVTNVCVPQQVTVGKPISWI--SCGYYHSAFVT--------- 206
Query: 454 SNCSSGKLFTWGDGDKGRLGHGDK--EAKLVPTCVALVEHNFCQVACGHSLTVALTTSGH 511
+ G+L+T+G+ + G+LG ++ +P V + QVACG TV LT
Sbjct: 207 ---TEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPGKVVQVACGGGHTVVLTEKA- 262
Query: 512 VYAMGSPVYGQ--LGNPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEVYTWGK 569
VY G +GQ LG + +P +E + + IACG H A++T +YT+G
Sbjct: 263 VYTFGLGQFGQLGLGTFLFETSVPKAIE-HIKDQKISFIACGENHTALITDMGLMYTFGD 321
Query: 570 GANGRLGHGDTDDRNN--PTLVDALKDKHVKSIACG 603
G +G+LG G + N PTL V+ ++CG
Sbjct: 322 GRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCG 357
Score = 125 bits (315), Expect = 5e-28
Identities = 92/290 (31%), Positives = 142/290 (48%), Gaps = 24/290 (8%)
Query: 326 VACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGP 385
++CG+ HT VT + LY +G+ N+G LG G++ + P V L+ V + +CG
Sbjct: 40 LSCGDEHTAVVTGNNKLYMFGSN--NWGQLGLGSKSTVSKPTCVKA-LKPEKVKFAACGR 96
Query: 386 WHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRA-SCGVWHTAAVV 444
HT V T G+++ G G LG GD + S + R ++ S G
Sbjct: 97 NHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAG-------- 148
Query: 445 EVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQVACGHSLTV 504
N+S++ G+LF WGD +G++G + VP V V ++CG+ +
Sbjct: 149 ----SNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVT-VGKPISWISCGYYHSA 203
Query: 505 ALTTSGHVYAMGSPVYGQLGNPQ---ADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLR 561
+TT G +Y G P G+LG P + ++P V G + V ++ACG H VLT
Sbjct: 204 FVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPG--IPGKVVQVACGGGHTVVLT-E 260
Query: 562 NEVYTWGKGANGRLGHGD-TDDRNNPTLVDALKDKHVKSIACGTNFTAAI 610
VYT+G G G+LG G + + P ++ +KD+ + IACG N TA I
Sbjct: 261 KAVYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALI 310
Score = 115 bits (288), Expect = 6e-25
Identities = 92/324 (28%), Positives = 156/324 (47%), Gaps = 28/324 (8%)
Query: 242 GGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRL 301
G N+ GLG K P +++ V+ ACG H + T+ G++++ G + G+L
Sbjct: 60 GSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQL 119
Query: 302 GHGVDSDVLHPKLIDAL-SNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQ 360
G G + LI S I+ ++ G + A+T G+L+ WG+ + G +G N
Sbjct: 120 GLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDN--SEGQIGLENV 177
Query: 361 VSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVS--L 418
+ VP++V G +S+ISCG +H+A VT+ GQL+TFG+ G LG ++ V+ +
Sbjct: 178 TNVCVPQQVT---VGKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRM 234
Query: 419 PREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGD-- 476
P+ V + G + ++ +CG HT + E V +T+G G G+LG G
Sbjct: 235 PQPVPGIPG-KVVQVACGGGHTVVLTEKAV-------------YTFGLGQFGQLGLGTFL 280
Query: 477 KEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLG---NPQADGKLP 533
E + + + +ACG + T +T G +Y G +G+LG + +P
Sbjct: 281 FETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIP 340
Query: 534 TRVEGKLLKSFVEEIACGAYHVAV 557
T + L+ V+ ++CG H V
Sbjct: 341 T-LCSNFLRFIVQLVSCGGCHTLV 363
Score = 109 bits (273), Expect = 3e-23
Identities = 87/280 (31%), Positives = 136/280 (48%), Gaps = 26/280 (9%)
Query: 236 GDGVVGGGNHRVGSGLG-VKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWG 294
G GGN+ GLG + S F ++ ++ G +A +T+ GE+F WG
Sbjct: 106 GKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWG 165
Query: 295 EESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGL 354
+ S G++G ++V P+ + I ++CG YH+ VT G LYT+G G
Sbjct: 166 DNSEGQIGLENVTNVCVPQQVTV--GKPISWISCGYYHSAFVTTEGQLYTFGEP--ECGK 221
Query: 355 LGHGNQ--VSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGD 412
LG NQ V+H +P+ V G + G V ++CG HT V+T ++TFG G FG LG G
Sbjct: 222 LGLPNQLLVNHRMPQPVPG-IPG-KVVQVACGGGHTVVLTEKA-VYTFGLGQFGQLGLGT 278
Query: 413 -RKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGR 471
S+P+ +E +K + +CG HTA + ++ G ++T+GDG G+
Sbjct: 279 FLFETSVPKAIEHIKDQKISFIACGENHTALITDM------------GLMYTFGDGRHGK 326
Query: 472 LGHG--DKEAKLVPT-CVALVEHNFCQVACGHSLTVALTT 508
LG G + + +PT C + V+CG T+ T
Sbjct: 327 LGLGLENSTNQFIPTLCSNFLRFIVQLVSCGGCHTLVFAT 366
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC
2.7.1.37) (NimA-related protein kinase 8)
Length = 698
Score = 126 bits (316), Expect = 4e-28
Identities = 103/331 (31%), Positives = 149/331 (44%), Gaps = 42/331 (12%)
Query: 302 GHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGN---GAYNYGLLGHG 358
G G+ S + P L NT + VA G VT SG L W GA LL
Sbjct: 324 GGGLSSPLRLPML-----NTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGA 378
Query: 359 NQVSHWVPKRVNGPLEG---IHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKS 415
++ P+ V+ LEG + + +++CG TA +T G + TFG G+ G LGHG+
Sbjct: 379 VELPQ--PQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTD 436
Query: 416 VSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHG 475
+S P VE+L G ++ +CG H A+ + G+LF WG GD GRLG G
Sbjct: 437 ISQPTIVEALLGYEMVQVACGASHVLAL------------STDGELFAWGRGDGGRLGLG 484
Query: 476 DKEAKLVPTCVALVEHNFCQ-VACGHSLTVALTTSGHVYAMGSPVYGQLGNPQA---DGK 531
+E+ P V + Q V CG ++ LT+ G V A GS + +LG +
Sbjct: 485 TRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEP 544
Query: 532 LPTRVEGKLLKSFV---------EEIAC---GAYHVAVLTLRNEVYTWGKGANGRLGHGD 579
+P + + L SF E + C G H A +T + YT+G +G+LG
Sbjct: 545 VPYQQVEEAL-SFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSS 603
Query: 580 TDDRNNPTLVDALKDKHVKSIACGTNFTAAI 610
P V L+ + +ACG FT A+
Sbjct: 604 RRVSRAPCRVQGLEGIKMVMVACGDAFTVAV 634
Score = 123 bits (308), Expect = 3e-27
Identities = 104/357 (29%), Positives = 154/357 (43%), Gaps = 40/357 (11%)
Query: 270 DVQNIACGGRHAALVTKQGEIFSWGEE----SGGRLGHG---VDSDVLHPKLIDALSNTN 322
+V +A G A VT+ G + W GG L G + + ++ S
Sbjct: 339 EVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQSGVT 398
Query: 323 IELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYIS 382
I+ VACG+ T +T G + T+G+G+ G LGHGN P V L G + ++
Sbjct: 399 IKHVACGDLFTACLTDRGIIMTFGSGSN--GCLGHGNLTDISQPTIVEALL-GYEMVQVA 455
Query: 383 CGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAA 442
CG H +++ G+LF +G G G LG G R+S + P++V G R CG+
Sbjct: 456 CGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGI----- 510
Query: 443 VVEVMVGNSSSSNCSSGKLFTWGDGDKGRLG--HGDKEAKLVPT-------------CVA 487
+SS S G++ G +LG H + + VP
Sbjct: 511 -------DSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAP 563
Query: 488 LVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLG-NPQADGKLPTRVEGKLLKSFVE 546
L + V G + + A+T SG Y GS +GQLG + + + P RV+G L +
Sbjct: 564 LDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQG-LEGIKMV 622
Query: 547 EIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTD-DRNNPTLVDALKDKHVKSIAC 602
+ACG + EVY+WGKG GRLG D D P +D V S++C
Sbjct: 623 MVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSC 679
Score = 120 bits (302), Expect = 1e-26
Identities = 83/279 (29%), Positives = 134/279 (47%), Gaps = 8/279 (2%)
Query: 263 LESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTN 322
LE + ++++ACG A +T +G I ++G S G LGHG +D+ P +++AL
Sbjct: 391 LEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYE 450
Query: 323 IELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYIS 382
+ VACG H A++ G+L+ WG G + G LG G + SH P++V G +
Sbjct: 451 MVQVACGASHVLALSTDGELFAWGRG--DGGRLGLGTRESHNCPQQV-PVAPGQEAQRVV 507
Query: 383 CGPWHTAVVTSAGQLFTFGDGTFGALG--HGDRKSVSLP-REVESLKGLRTMRASCGVWH 439
CG + ++TS G++ G F LG H +P ++VE + ++
Sbjct: 508 CGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQE 567
Query: 440 TAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEH-NFCQVAC 498
V++ +S++ +SG +T+G G+LG + P V +E VAC
Sbjct: 568 PLLCVDLGTAHSAAIT-ASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVAC 626
Query: 499 GHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVE 537
G + TVA+ G VY+ G G+LG D LP V+
Sbjct: 627 GDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQ 665
Score = 109 bits (272), Expect = 4e-23
Identities = 80/298 (26%), Positives = 132/298 (43%), Gaps = 37/298 (12%)
Query: 226 GDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVT 285
G + +G G+ +G +G GN D P +E+ + ++ +ACG H ++
Sbjct: 416 GIIMTFGSGS-NGCLGHGN---------LTDISQPTIVEALLGYEMVQVACGASHVLALS 465
Query: 286 KQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTW 345
GE+F+WG GGRLG G P+ + + V CG + +T G +
Sbjct: 466 TDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLAC 525
Query: 346 GNGAYNYGLLGHGNQVSHWVPKRV-----------NGPLEGIHVSYISCGPWHTAVVTSA 394
G+ +N L H + VP + + PL+ + + G H+A +T++
Sbjct: 526 GSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITAS 585
Query: 395 GQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSS 454
G +TFG G LG R+ P V+ L+G++ + +CG T AV
Sbjct: 586 GDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAV----------- 634
Query: 455 NCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVE---HNFCQVACGHSLTVALTTS 509
+ G++++WG G +GRLG D++A L P V L E + V+C H T+ S
Sbjct: 635 -GAEGEVYSWGKGTRGRLGRRDEDAGL-PRPVQLDETHPYMVTSVSCCHGNTLLAVRS 690
Score = 67.4 bits (163), Expect = 2e-10
Identities = 52/172 (30%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 483 PTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADG--KLPTRVEGKL 540
P + ++ QVA G + +T SG + +P G G G +LP + +
Sbjct: 330 PLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELP---QPQF 386
Query: 541 LKSFVE--------EIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDAL 592
+ F+E +ACG A LT R + T+G G+NG LGHG+ D + PT+V+AL
Sbjct: 387 VSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEAL 446
Query: 593 KDKHVKSIACGTNFTAAIC----LHKWVSGVDQSMCSGCRLPFNFKRKRHNC 640
+ +ACG + A+ L W G G RL R+ HNC
Sbjct: 447 LGYEMVQVACGASHVLALSTDGELFAWGRG------DGGRLGLG-TRESHNC 491
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC
2.7.1.37) (NimA-related protein kinase 8) (NIMA-related
kinase 12a)
Length = 692
Score = 125 bits (314), Expect = 6e-28
Identities = 104/350 (29%), Positives = 160/350 (45%), Gaps = 26/350 (7%)
Query: 270 DVQNIACGGRHAALVTKQGEIFSW-----GEESGGRLGHGVDSDVLH--PKLIDALSNTN 322
+V +A G A VT+ G + W G G L V+ + ++ S
Sbjct: 333 EVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVT 392
Query: 323 IELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYIS 382
I+ VACG++ T +T G + T+G+G+ G LGHG+ P V L G + ++
Sbjct: 393 IKHVACGDFFTACLTDRGIIMTFGSGSN--GCLGHGSLTDISQPTIVEALL-GYEMVQVA 449
Query: 383 CGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAA 442
CG H +++ +LF +G G G LG G R+S S P++V G R CG+ ++
Sbjct: 450 CGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGI--DSS 507
Query: 443 VVEVMVGNSSSSNCSSGKLFTWGDGDKGRLG-----HGDKEAKLVPTCVA---LVEHNFC 494
++ + G + + C S + G D LG H E L T + L +
Sbjct: 508 MILTVPGQALA--CGSNRFNKLGL-DHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLL 564
Query: 495 QVACGHSLTVALTTSGHVYAMGSPVYGQLG-NPQADGKLPTRVEGKLLKSFVEEIACGAY 553
+ G + + A+T SG Y GS +GQLG N + + P +V+G L + +ACG
Sbjct: 565 SIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG-LEGIKMAMVACGDA 623
Query: 554 HVAVLTLRNEVYTWGKGANGRLGHGDTD-DRNNPTLVDALKDKHVKSIAC 602
+ +EVY+WGKGA GRLG D D P +D V S++C
Sbjct: 624 FTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
Score = 124 bits (312), Expect = 1e-27
Identities = 105/360 (29%), Positives = 153/360 (42%), Gaps = 48/360 (13%)
Query: 272 QNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEY 331
+ I G A+ +++WG G LG + +L NT + VA G
Sbjct: 296 RGIPRGPVRPAIPPPLSSVYAWG----GGLGTPLRLPML---------NTEVVQVAAGRT 342
Query: 332 HTCAVTLSGDLYTWGN---GAYNYGLLGHGNQVSHWVPKRVNGPLEG---IHVSYISCGP 385
VT SG L W GA LL V P+ ++ LEG + + +++CG
Sbjct: 343 QKAGVTRSGRLILWEAPPLGAGGGSLLP--GAVEQPQPQFISRFLEGQSGVTIKHVACGD 400
Query: 386 WHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVE 445
+ TA +T G + TFG G+ G LGHG +S P VE+L G ++ +CG H A+
Sbjct: 401 FFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLAL-- 458
Query: 446 VMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQ-VACGHSLTV 504
+ +LF WG GD GRLG G +E+ P V + Q V CG ++
Sbjct: 459 ----------STERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSM 508
Query: 505 ALTTSGHVYAMGSPVYGQLG------------NPQADGKLPTRVEGK--LLKSFVEEIAC 550
LT G A GS + +LG + Q + L + G L + + I
Sbjct: 509 ILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDL 568
Query: 551 GAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIACGTNFTAAI 610
G H A +T + YT+G +G+LG P V L+ + +ACG FT AI
Sbjct: 569 GTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAI 628
Score = 117 bits (292), Expect = 2e-25
Identities = 82/279 (29%), Positives = 131/279 (46%), Gaps = 8/279 (2%)
Query: 263 LESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTN 322
LE + ++++ACG A +T +G I ++G S G LGHG +D+ P +++AL
Sbjct: 385 LEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYE 444
Query: 323 IELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYIS 382
+ VACG H A++ +L+ WG G + G LG G + SH P++V P G +
Sbjct: 445 MVQVACGASHVLALSTERELFAWGRG--DSGRLGLGTRESHSCPQQVPMP-PGQEAQRVV 501
Query: 383 CGPWHTAVVTSAGQLFTFGDGTFGALG--HGDRKSVSLPREVESLKGLRTMRASCGVWHT 440
CG + ++T GQ G F LG H +P + T+ S +
Sbjct: 502 CGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL-DQ 560
Query: 441 AAVVEVMVGNS-SSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEH-NFCQVAC 498
++ + +G + S++ +SG +T+G G+LG + P V +E VAC
Sbjct: 561 EPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVAC 620
Query: 499 GHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVE 537
G + TVA+ VY+ G G+LG D LP V+
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQ 659
Score = 102 bits (255), Expect = 4e-21
Identities = 73/274 (26%), Positives = 120/274 (43%), Gaps = 27/274 (9%)
Query: 250 GLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDV 309
G G D P +E+ + ++ +ACG H ++ + E+F+WG GRLG G
Sbjct: 424 GHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESH 483
Query: 310 LHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRV 369
P+ + + V CG + +T+ G G+ +N L H + VP +
Sbjct: 484 SCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQ 543
Query: 370 -----------NGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSL 418
+ PL+ + I G H+A VT++G +TFG G LG R+
Sbjct: 544 VEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA 603
Query: 419 PREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKE 478
P +V+ L+G++ +CG T A+ + ++++WG G +GRLG D++
Sbjct: 604 PCKVQGLEGIKMAMVACGDAFTVAI------------GAESEVYSWGKGARGRLGRRDED 651
Query: 479 AKLVPTCVALVE---HNFCQVACGHSLTVALTTS 509
A L P V L E + V+C H T+ S
Sbjct: 652 AGL-PRPVQLDETHPYTVTSVSCCHGNTLLAVRS 684
Score = 39.7 bits (91), Expect = 0.043
Identities = 23/95 (24%), Positives = 41/95 (42%), Gaps = 1/95 (1%)
Query: 235 TGDGVVGGGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWG 294
+GD G N G + S P ++ + + +ACG + + E++SWG
Sbjct: 579 SGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG 638
Query: 295 EESGGRLG-HGVDSDVLHPKLIDALSNTNIELVAC 328
+ + GRLG D+ + P +D + V+C
Sbjct: 639 KGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC
2.7.1.37) (NimA-related protein kinase 8)
Length = 697
Score = 121 bits (304), Expect = 9e-27
Identities = 85/316 (26%), Positives = 151/316 (46%), Gaps = 11/316 (3%)
Query: 240 VGGGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGG 299
VG G + + + LE + +++++CG +T +G I ++G S G
Sbjct: 369 VGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNG 428
Query: 300 RLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGN 359
LGHG +DV PK+++AL + V+CG H AVT ++++WG G + G LG
Sbjct: 429 CLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRG--DNGRLGLAT 486
Query: 360 QVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLP 419
Q SH P++V+ P + + CG + ++++ Q+ G+ F LG P
Sbjct: 487 QDSHNCPQQVSLPAD-FEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEP 545
Query: 420 R---EVESLKGLRTMRASCGVWHTAAVVEVMVGNSSS-SNCSSGKLFTWGDGDKGRLGHG 475
+VE + + ++++ +T +V + +G + S + G+ FT+G G+LG
Sbjct: 546 SSFCQVEEVHLFQLVQSA--PLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCS 603
Query: 476 DKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTR 535
+ + VP V+ ++ ACG + T+A+ G VY G G+LG + D +P
Sbjct: 604 HRRSSRVPYQVSGLQ-GITMAACGDAFTLAIGAEGEVYTWGKGARGRLGRKEEDFGIPKP 662
Query: 536 VEGKLLKSF-VEEIAC 550
V+ +F V +AC
Sbjct: 663 VQLDESHAFTVTSVAC 678
Score = 117 bits (292), Expect = 2e-25
Identities = 93/327 (28%), Positives = 146/327 (44%), Gaps = 37/327 (11%)
Query: 302 GHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQV 361
G G+ + + P L NT + V+ G VT SG L TW + G V
Sbjct: 326 GSGISTPLRLPML-----NTEVIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAV 380
Query: 362 SHWVPKRVNGPLEG---IHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSL 418
P+ ++ LEG + + +SCG T +T G + TFG G+ G LGHG+ V+
Sbjct: 381 EQMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQ 440
Query: 419 PREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKE 478
P+ VE+L G ++ SCG H AV + ++F+WG GD GRLG ++
Sbjct: 441 PKIVEALLGYELVQVSCGASHVLAVT------------NEREVFSWGRGDNGRLGLATQD 488
Query: 479 AKLVPTCVAL-VEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADG-KLPT-- 534
+ P V+L + +V CG ++ ++T + A G+ + +LG + G + P+
Sbjct: 489 SHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSF 548
Query: 535 -RVEGKLLKSFVEE----------IACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDR 583
+VE L V+ I G H +T + + +T+G +G+LG
Sbjct: 549 CQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSS 608
Query: 584 NNPTLVDALKDKHVKSIACGTNFTAAI 610
P V L+ + ACG FT AI
Sbjct: 609 RVPYQVSGLQG--ITMAACGDAFTLAI 633
Score = 109 bits (272), Expect = 4e-23
Identities = 97/356 (27%), Positives = 148/356 (41%), Gaps = 41/356 (11%)
Query: 270 DVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDV--LHPKLI----DALSNTNI 323
+V ++ G VTK G + +W S G + V + P+ I + S I
Sbjct: 341 EVIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTI 400
Query: 324 ELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISC 383
+ V+CG+ T +T G + T+G+G+ G LGHGN PK V L G + +SC
Sbjct: 401 KSVSCGDLFTTCLTDRGIIMTFGSGSN--GCLGHGNFNDVTQPKIVEALL-GYELVQVSC 457
Query: 384 GPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAV 443
G H VT+ ++F++G G G LG + S + P++V R CGV
Sbjct: 458 GASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGV------ 511
Query: 444 VEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEH------------ 491
+ S + ++ G+ +LG P+ VE
Sbjct: 512 ------DCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPL 565
Query: 492 ---NFCQVACGHSLTVALTTSGHVYAMGSPVYGQLG-NPQADGKLPTRVEGKLLKSFVEE 547
+ G + +VA+T G + GS +GQLG + + ++P +V G +
Sbjct: 566 NTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGL---QGITM 622
Query: 548 IACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTD-DRNNPTLVDALKDKHVKSIAC 602
ACG + EVYTWGKGA GRLG + D P +D V S+AC
Sbjct: 623 AACGDAFTLAIGAEGEVYTWGKGARGRLGRKEEDFGIPKPVQLDESHAFTVTSVAC 678
Score = 63.2 bits (152), Expect = 4e-09
Identities = 40/158 (25%), Positives = 72/158 (45%), Gaps = 22/158 (13%)
Query: 461 LFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVY 520
++TWG G P + ++ QV+ G + + +T SG + +P
Sbjct: 322 VYTWGSGIS------------TPLRLPMLNTEVIQVSLGRTQKMGVTKSGRLITWEAPSV 369
Query: 521 GQLGNPQADGKLPTRVEGKLLKSFVE--------EIACGAYHVAVLTLRNEVYTWGKGAN 572
G G P G + +++ + + F+E ++CG LT R + T+G G+N
Sbjct: 370 GS-GEPTLPGAVE-QMQPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSN 427
Query: 573 GRLGHGDTDDRNNPTLVDALKDKHVKSIACGTNFTAAI 610
G LGHG+ +D P +V+AL + ++CG + A+
Sbjct: 428 GCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAV 465
>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC
2.7.1.37) (NimA-related protein kinase 9) (XNek9)
(Nercc1 kinase)
Length = 944
Score = 116 bits (290), Expect = 4e-25
Identities = 101/351 (28%), Positives = 149/351 (41%), Gaps = 48/351 (13%)
Query: 281 AALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNT-NIELVACGEYHTCAVTLS 339
A + ++ E++ WG GG+ P+ +D V G+ H VT+
Sbjct: 322 AVVTSRSSEVYVWG---GGKTT---------PQKLDVFKGGWRARQVCAGDAHFAVVTVE 369
Query: 340 GDLYTWGN---GAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQ 396
+LYTW N G+ +G LGHG++ S+ PK V L+G V +SCG T +T GQ
Sbjct: 370 KELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVE-KLQGKSVQKVSCGSDFTVCITDEGQ 428
Query: 397 LFTFGDGTFGALGHGDR--KSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSS 454
L++FG +G LG V P V+ + SCG H A+
Sbjct: 429 LYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTR--------- 479
Query: 455 NCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFC--QVACGHSLTVALTTSGHV 512
S +++WG G+ GRLG ++ P V V+ C V CG + LT +G V
Sbjct: 480 ---SKSVYSWGCGEYGRLGLDSEDDVYSPQKVE-VQRGLCIVNVCCGSDGSFLLTLTGKV 535
Query: 513 YAMGSPVYGQLG---------NPQADGKLPTRVEGKLLKSF----VEEIACGAYHVAVLT 559
A G + +LG N +A ++P L K + I+ G H A +
Sbjct: 536 LACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAID 595
Query: 560 LRNEVYTWGKGANGRLGHGDTDDRNNPTLVDA-LKDKHVKSIACGTNFTAA 609
R + T+G G+LG GD L+ L K V ++CG FT A
Sbjct: 596 ERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTA 646
Score = 107 bits (266), Expect = 2e-22
Identities = 86/326 (26%), Positives = 139/326 (42%), Gaps = 37/326 (11%)
Query: 272 QNIACGGRHAALVTKQGEIFSW-----GEESGGRLGHGVDSDVLHPKLIDALSNTNIELV 326
+ + G H A+VT + E+++W G + G+LGHG + PK ++ L +++ V
Sbjct: 354 RQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKV 413
Query: 327 ACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWV--PKRVNGPLEGIHVSYISCG 384
+CG T +T G LY++G+ Y G LG V P V+ L V +SCG
Sbjct: 414 SCGSDFTVCITDEGQLYSFGSDYY--GCLGVNQSAGSEVLEPLLVDFFLNE-PVDQVSCG 470
Query: 385 PWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVV 444
H +T + ++++G G +G LG V P++VE +GL + CG
Sbjct: 471 DSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCG-------- 522
Query: 445 EVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLV----------PTCVALVE---- 490
+ S +GK+ G + +LG A ++ T + L +
Sbjct: 523 ----SDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSF 578
Query: 491 HNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRV-EGKLLKSFVEEIA 549
+ ++ G + T A+ G + GS GQLG L + G L V ++
Sbjct: 579 YKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVS 638
Query: 550 CGAYHVAVLTLRNEVYTWGKGANGRL 575
CG T N ++ WG G NGRL
Sbjct: 639 CGDEFTTAATADNHIFAWGNGGNGRL 664
Score = 104 bits (260), Expect = 1e-21
Identities = 91/343 (26%), Positives = 147/343 (42%), Gaps = 42/343 (12%)
Query: 241 GGGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGR 300
GG G G + PK +E VQ ++CG +T +G+++S+G + G
Sbjct: 380 GGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGC 439
Query: 301 LG--HGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHG 358
LG S+VL P L+D N ++ V+CG+ H A+T S +Y+WG G YG LG
Sbjct: 440 LGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSWGCG--EYGRLGLD 497
Query: 359 NQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFG----------DGTFGAL 408
++ + P++V G+ + + CG + ++T G++ G T G +
Sbjct: 498 SEDDVYSPQKVE-VQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGII 556
Query: 409 GHGDRKSVSLPREVESLKGL---RTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWG 465
H + V + K L + S G HTAA+ E G+L T+G
Sbjct: 557 NHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDE------------RGRLLTFG 604
Query: 466 DGDKGRLGHGDKEAKLVPTCVA--LVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQL 523
G+LG GD L + L +V+CG T A T H++A G+ G+L
Sbjct: 605 SNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRL 664
Query: 524 G---NPQADG-----KLPTRVEGKLLKSFVEEIACGAYHVAVL 558
N + G P + G L V +++C +H ++
Sbjct: 665 AMTPNERPQGSDICTSWPRPIFGSL--HHVTDLSCRGWHTILI 705
Score = 72.0 bits (175), Expect = 8e-12
Identities = 65/231 (28%), Positives = 99/231 (42%), Gaps = 25/231 (10%)
Query: 250 GLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLG------- 302
GL + D P+ +E L + N+ CG + L+T G++ + G +LG
Sbjct: 495 GLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAG 554
Query: 303 ---HGVDSDVLHPK---LIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLG 356
H +V + L LS I ++ G HT A+ G L T+G+ G LG
Sbjct: 555 IINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSN--KCGQLG 612
Query: 357 HGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALG------- 409
G+ H + GPL G V +SCG T T+ +F +G+G G L
Sbjct: 613 VGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRLAMTPNERP 672
Query: 410 HGDRKSVSLPREV-ESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSG 459
G S PR + SL + + SC WHT +VE ++ + + + SSG
Sbjct: 673 QGSDICTSWPRPIFGSLHHVTDL--SCRGWHTILIVEKVLNSKTIRSNSSG 721
Score = 56.6 bits (135), Expect = 3e-07
Identities = 26/69 (37%), Positives = 40/69 (57%), Gaps = 5/69 (7%)
Query: 547 EIACGAYHVAVLTLRNEVYTW-----GKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIA 601
++ G H AV+T+ E+YTW G +G+LGHGD P V+ L+ K V+ ++
Sbjct: 355 QVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVS 414
Query: 602 CGTNFTAAI 610
CG++FT I
Sbjct: 415 CGSDFTVCI 423
Score = 46.6 bits (109), Expect = 4e-04
Identities = 36/130 (27%), Positives = 61/130 (46%), Gaps = 9/130 (6%)
Query: 495 QVACGHSLTVALTTSGHVYAM-----GSPVYGQLGN-PQADGKLPTRVEGKLLKSFVEEI 548
QV G + +T +Y GS ++GQLG+ +A + P VE KL V+++
Sbjct: 355 QVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVE-KLQGKSVQKV 413
Query: 549 ACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRN--NPTLVDALKDKHVKSIACGTNF 606
+CG+ +T ++Y++G G LG + P LVD ++ V ++CG +
Sbjct: 414 SCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSH 473
Query: 607 TAAICLHKWV 616
A+ K V
Sbjct: 474 IMALTRSKSV 483
>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC
2.7.1.37) (NimA-related protein kinase 9)
Length = 984
Score = 114 bits (286), Expect = 1e-24
Identities = 107/354 (30%), Positives = 155/354 (43%), Gaps = 54/354 (15%)
Query: 281 AALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDAL-SNTNIELVACGEYHTCAVTLS 339
A + ++ E++ WG GG+ P+ +D + S + V G H VT+
Sbjct: 340 AVVTSRTSEVYVWG---GGKST---------PQKLDVIKSGCSARQVCAGNTHFAVVTVE 387
Query: 340 GDLYTWGN---GAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQ 396
+LYTW N G +G LGHG++ S+ PK V L+G + +SCG T VT GQ
Sbjct: 388 KELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVE-KLQGKAIHQVSCGDDFTVCVTDEGQ 446
Query: 397 LFTFGDGTFGALGHGDRKS---VSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSS 453
L+ FG +G +G D+ S V P ++ + SCG H V V+ N
Sbjct: 447 LYAFGSDYYGCMG-VDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNH----VVVLTRNK-- 499
Query: 454 SNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCV----ALVEHNFCQVACGHSLTVALTTS 509
++++WG G+ GRLG +E P V AL+ V CG T LT S
Sbjct: 500 ------EVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALI---IVAVQCGCDGTFLLTQS 550
Query: 510 GHVYAMGSPVYGQLG---------NPQADGKLPTRVEGKLLKSF----VEEIACGAYHVA 556
G V A G + +LG N +A ++P L K + IA G H A
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
Query: 557 VLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDA-LKDKHVKSIACGTNFTAA 609
+ R + T+G G+LG G+ R L+ L K V ++CG FT A
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIA 664
Score = 102 bits (255), Expect = 4e-21
Identities = 88/334 (26%), Positives = 141/334 (41%), Gaps = 41/334 (12%)
Query: 272 QNIACGGRHAALVTKQGEIFSW-----GEESGGRLGHGVDSDVLHPKLIDALSNTNIELV 326
+ + G H A+VT + E+++W G + G+LGHG + PK ++ L I V
Sbjct: 372 RQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQV 431
Query: 327 ACGEYHTCAVTLSGDLYTWGNGAYNYGLLG----HGNQVSHWVPKRVNGPLEGIHVSYIS 382
+CG+ T VT G LY +G+ YG +G G +V P ++N L V +S
Sbjct: 432 SCGDDFTVCVTDEGQLYAFGSD--YYGCMGVDKVSGPEVLE--PMQLNFFLSN-PVEQVS 486
Query: 383 CGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAA 442
CG H V+T +++++G G +G LG + P+ V+ K L + CG T
Sbjct: 487 CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFL 546
Query: 443 VVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLV----------PTCVALVE-- 490
+ + SGK+ G + +LG + ++ T L +
Sbjct: 547 LTQ------------SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQL 594
Query: 491 --HNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTR-VEGKLLKSFVEE 547
+ +A G + T A+ G + G GQLG +L + G L V
Sbjct: 595 SFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIR 654
Query: 548 IACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTD 581
++CG T N ++ WG G NGRL T+
Sbjct: 655 VSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688
Score = 97.4 bits (241), Expect = 2e-19
Identities = 80/250 (32%), Positives = 115/250 (46%), Gaps = 38/250 (15%)
Query: 369 VNGPLEGIHVSYISCGPWHTAVVTS-AGQLFTFGDGTFGALGHGDRKSVSLPREVESLKG 427
+N P + S ++ P AVVTS +++ +G G S P++++ +K
Sbjct: 322 LNAPTKRPRSSTVTEAP--IAVVTSRTSEVYVWGGGK------------STPQKLDVIKS 367
Query: 428 LRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTW-----GDGDKGRLGHGDKEAKLV 482
+ R C AVV V +L+TW G G+LGHGDK +
Sbjct: 368 GCSARQVCAGNTHFAVVTV-----------EKELYTWVNMQGGTKLHGQLGHGDKASYRQ 416
Query: 483 PTCVALVEHNFC-QVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLL 541
P V ++ QV+CG TV +T G +YA GS YG +G + G P +E L
Sbjct: 417 PKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSG--PEVLEPMQL 474
Query: 542 KSF----VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHV 597
F VE+++CG HV VLT EVY+WG G GRLG +D P VD K +
Sbjct: 475 NFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALII 534
Query: 598 KSIACGTNFT 607
++ CG + T
Sbjct: 535 VAVQCGCDGT 544
Score = 84.0 bits (206), Expect = 2e-15
Identities = 65/228 (28%), Positives = 97/228 (42%), Gaps = 27/228 (11%)
Query: 258 LFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDA 317
L P L + V+ ++CG H ++T+ E++SWG GRLG + D P+ +D
Sbjct: 469 LEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDV 528
Query: 318 LSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYN--------YGLLGHGNQVSHWVPKRV 369
I V CG T +T SG + G +N G++ H + H VP
Sbjct: 529 PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINH--EAYHEVPYTT 586
Query: 370 N----GPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGD-RKSVSLPREVES 424
+ L + I+ G HTA + G+L TFG G LG G+ +K + +
Sbjct: 587 SFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGP 646
Query: 425 LKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRL 472
L G + +R SCG T A + +F WG+G GRL
Sbjct: 647 LGGKQVIRVSCGDEFTIAATD------------DNHIFAWGNGGNGRL 682
Score = 70.9 bits (172), Expect = 2e-11
Identities = 64/231 (27%), Positives = 97/231 (41%), Gaps = 25/231 (10%)
Query: 250 GLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHG----- 304
GL + D P+ ++ L + + CG L+T+ G++ + G +LG
Sbjct: 513 GLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSG 572
Query: 305 -VDSDVLHP-------KLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLG 356
++ + H L LS I +A G+ HT A+ G L T+G G LG
Sbjct: 573 IINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFG--CNKCGQLG 630
Query: 357 HGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALG------- 409
GN + GPL G V +SCG T T +F +G+G G L
Sbjct: 631 VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERP 690
Query: 410 HGDRKSVSLPREV-ESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSG 459
HG S PR + SL + + SC WHT +VE ++ + + + SSG
Sbjct: 691 HGSDICTSWPRPIFGSLHHVPDL--SCRGWHTILIVEKVLNSKTIRSNSSG 739
Score = 53.5 bits (127), Expect = 3e-06
Identities = 24/69 (34%), Positives = 38/69 (54%), Gaps = 5/69 (7%)
Query: 547 EIACGAYHVAVLTLRNEVYTW-----GKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIA 601
++ G H AV+T+ E+YTW G +G+LGHGD P V+ L+ K + ++
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVS 432
Query: 602 CGTNFTAAI 610
CG +FT +
Sbjct: 433 CGDDFTVCV 441
>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC
2.7.1.37) (NimA-related protein kinase 9) (Nercc1
kinase) (NIMA-related kinase 8) (Nek8)
Length = 979
Score = 114 bits (284), Expect = 2e-24
Identities = 105/353 (29%), Positives = 152/353 (42%), Gaps = 52/353 (14%)
Query: 281 AALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDAL-SNTNIELVACGEYHTCAVTLS 339
A + ++ E++ WG GG+ P+ +D + S + V G H VT+
Sbjct: 340 AVVTSRTSEVYVWG---GGKST---------PQKLDVIKSGCSARQVCAGNTHFAVVTVE 387
Query: 340 GDLYTWGN---GAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQ 396
+LYTW N G +G LGHG++ S+ PK V L+G + +SCG T VT GQ
Sbjct: 388 KELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVE-KLQGKAIHQVSCGDDFTVCVTDEGQ 446
Query: 397 LFTFGDGTFGALGHGD--RKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSS 454
L+ FG +G +G V P ++ + SCG H V V+ N
Sbjct: 447 LYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNH----VVVLTRNK--- 499
Query: 455 NCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCV----ALVEHNFCQVACGHSLTVALTTSG 510
++++WG G+ GRLG +E P V AL+ V CG T LT SG
Sbjct: 500 -----EVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI---IVAVQCGCDGTFLLTQSG 551
Query: 511 HVYAMGSPVYGQLG---------NPQADGKLPTRVEGKLLKSF----VEEIACGAYHVAV 557
V A G + +LG N +A ++P L K + IA G H A
Sbjct: 552 KVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAA 611
Query: 558 LTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDA-LKDKHVKSIACGTNFTAA 609
+ R + T+G G+LG G+ R L+ L K V ++CG FT A
Sbjct: 612 IDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIA 664
Score = 103 bits (257), Expect = 2e-21
Identities = 87/332 (26%), Positives = 140/332 (41%), Gaps = 37/332 (11%)
Query: 272 QNIACGGRHAALVTKQGEIFSW-----GEESGGRLGHGVDSDVLHPKLIDALSNTNIELV 326
+ + G H A+VT + E+++W G + G+LGHG + PK ++ L I V
Sbjct: 372 RQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQV 431
Query: 327 ACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWV--PKRVNGPLEGIHVSYISCG 384
+CG+ T VT G LY +G+ YG +G V P ++N L V +SCG
Sbjct: 432 SCGDDFTVCVTDEGQLYAFGSD--YYGCMGVDKVAGPEVLEPMQLNFFLSN-PVEQVSCG 488
Query: 385 PWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVV 444
H V+T +++++G G +G LG + P++V+ K L + CG T +
Sbjct: 489 DNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLT 548
Query: 445 EVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLV----------PTCVALVE---- 490
+ SGK+ G + +LG + ++ T L +
Sbjct: 549 Q------------SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSF 596
Query: 491 HNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTR-VEGKLLKSFVEEIA 549
+ +A G + T A+ G + G GQLG +L + G L V ++
Sbjct: 597 YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVS 656
Query: 550 CGAYHVAVLTLRNEVYTWGKGANGRLGHGDTD 581
CG T N ++ WG G NGRL T+
Sbjct: 657 CGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE 688
Score = 96.7 bits (239), Expect = 3e-19
Identities = 80/250 (32%), Positives = 115/250 (46%), Gaps = 38/250 (15%)
Query: 369 VNGPLEGIHVSYISCGPWHTAVVTS-AGQLFTFGDGTFGALGHGDRKSVSLPREVESLKG 427
+N P + S ++ P AVVTS +++ +G G S P++++ +K
Sbjct: 322 LNAPTKRPRSSTVTEAP--IAVVTSRTSEVYVWGGGK------------STPQKLDVIKS 367
Query: 428 LRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTW-----GDGDKGRLGHGDKEAKLV 482
+ R C AVV V +L+TW G G+LGHGDK +
Sbjct: 368 GCSARQVCAGNTHFAVVTV-----------EKELYTWVNMQGGTKLHGQLGHGDKASYRQ 416
Query: 483 PTCVALVEHNFC-QVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLL 541
P V ++ QV+CG TV +T G +YA GS YG +G + G P +E L
Sbjct: 417 PKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAG--PEVLEPMQL 474
Query: 542 KSF----VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHV 597
F VE+++CG HV VLT EVY+WG G GRLG +D P VD K +
Sbjct: 475 NFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALII 534
Query: 598 KSIACGTNFT 607
++ CG + T
Sbjct: 535 VAVQCGCDGT 544
Score = 84.0 bits (206), Expect = 2e-15
Identities = 65/228 (28%), Positives = 97/228 (42%), Gaps = 27/228 (11%)
Query: 258 LFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDA 317
L P L + V+ ++CG H ++T+ E++SWG GRLG + D P+ +D
Sbjct: 469 LEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV 528
Query: 318 LSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYN--------YGLLGHGNQVSHWVPKRV 369
I V CG T +T SG + G +N G++ H + H VP
Sbjct: 529 PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINH--EAYHEVPYTT 586
Query: 370 N----GPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGD-RKSVSLPREVES 424
+ L + I+ G HTA + G+L TFG G LG G+ +K + +
Sbjct: 587 SFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGP 646
Query: 425 LKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRL 472
L G + +R SCG T A + +F WG+G GRL
Sbjct: 647 LGGKQVIRVSCGDEFTIAATD------------DNHIFAWGNGGNGRL 682
Score = 73.6 bits (179), Expect = 3e-12
Identities = 71/254 (27%), Positives = 105/254 (40%), Gaps = 29/254 (11%)
Query: 250 GLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHG----- 304
GL + D P+ ++ L + + CG L+T+ G++ + G +LG
Sbjct: 513 GLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSG 572
Query: 305 -VDSDVLHP-------KLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLG 356
++ + H L LS I +A G+ HT A+ G L T+G G LG
Sbjct: 573 IINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFG--CNKCGQLG 630
Query: 357 HGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALG------- 409
GN + GPL G V +SCG T T +F +G+G G L
Sbjct: 631 VGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERP 690
Query: 410 HGDRKSVSLPREV-ESLKGLRTMRASCGVWHTAAVVEVMVGN----SSSSNCSSGKLFTW 464
HG S PR + SL + + SC WHT +VE ++ + S+SS S G +F
Sbjct: 691 HGSDICTSWPRPIFGSLHHVPDL--SCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQS 748
Query: 465 GDGDKGRLGHGDKE 478
G G G +E
Sbjct: 749 SSPGGGGGGGGGEE 762
Score = 53.5 bits (127), Expect = 3e-06
Identities = 24/69 (34%), Positives = 38/69 (54%), Gaps = 5/69 (7%)
Query: 547 EIACGAYHVAVLTLRNEVYTW-----GKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIA 601
++ G H AV+T+ E+YTW G +G+LGHGD P V+ L+ K + ++
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVS 432
Query: 602 CGTNFTAAI 610
CG +FT +
Sbjct: 433 CGDDFTVCV 441
>RCC1_DROME (P25171) Regulator of chromosome condensation
(Chromatin-binding protein Bj1)
Length = 547
Score = 109 bits (273), Expect = 3e-23
Identities = 98/354 (27%), Positives = 151/354 (41%), Gaps = 17/354 (4%)
Query: 243 GNHRVGSGLGVKIDSLFPKALES-AVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRL 301
GN VG LG+ D L K L A + D +I+ GG H ++TK G+I+S+G G L
Sbjct: 48 GNGDVGQ-LGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGAL 106
Query: 302 GHGVDSDVLH--PKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGN 359
G D P LID ++ G+ H+ + G ++ WG+ ++G +G
Sbjct: 107 GRDTSEDGSESKPDLIDLPGKALC--ISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTI 164
Query: 360 QVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLP 419
+ P + +EG I+ G H ++T+AG++FT G G LG +S+S
Sbjct: 165 DGNKRTPIDL---MEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSIS-- 219
Query: 420 REVESLKGLRTMRASCGVWHTAA--VVEVMVGNSSSSNCSSGKLFTWGDGDKG--RLGHG 475
E +G R + + T A + N + S W G +L H
Sbjct: 220 --GEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHE 277
Query: 476 DKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTR 535
K + T + + +A G TV LTT +G P YG+LG +
Sbjct: 278 TKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKP 337
Query: 536 VEGKLLKSFVEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLV 589
K L + + CG +T+ ++Y+WG G N +LG GD DD P +V
Sbjct: 338 TIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVV 391
Score = 68.2 bits (165), Expect = 1e-10
Identities = 123/565 (21%), Positives = 210/565 (36%), Gaps = 86/565 (15%)
Query: 285 TKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIEL-VACGEYHTCAVTLSGDLY 343
T G + G G+LG G D+L K + ++ + ++ G H +T SGD+Y
Sbjct: 39 TVLGNVLVCGNGDVGQLGLG--EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIY 96
Query: 344 TWGNGAYNYGLLGHGNQV--SHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFG 401
++G + G LG S P ++ P + + IS G H+A + G++F +G
Sbjct: 97 SFG--CNDEGALGRDTSEDGSESKPDLIDLPGKAL---CISAGDSHSACLLEDGRVFAWG 151
Query: 402 D-----GTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNC 456
G G G++++ ++ ++G + G H +
Sbjct: 152 SFRDSHGNMGLTIDGNKRT-----PIDLMEGTVCCSIASGADHLVILT------------ 194
Query: 457 SSGKLFTWGDGDKGRLGH-----------GDKEAKLVPTCVALVEHNFCQV--ACGHSLT 503
++GK+FT G ++G+LG K L PT + + + A +
Sbjct: 195 TAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTF 254
Query: 504 VALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNE 563
+ + + ++A G + QL + + GK K + IA G +H +LT +
Sbjct: 255 MRESQTQVIWATGLNNFKQLAH-ETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLK 313
Query: 564 VYTWGKGANGRLGHGDTDD-RNNPTLVDALKDKHVKSIACGTNFTAAIC----LHKWVSG 618
G+ GRLG GD D PT+V L +K + S+ CG + A+ L+ W SG
Sbjct: 314 CSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEK-IVSVGCGEVCSYAVTIDGKLYSWGSG 372
Query: 619 VDQSMCSGCRLPFNFKRKRHNCYNCGLVFCHSCSSKKSLKASMAPNPNKPYRVCDGCFNK 678
V+ + G + +V + K L AS F
Sbjct: 373 VNNQLGVG---------DGDDELEPIVVVSKNTQGKHMLLASGGGQ--------HAIF-- 413
Query: 679 LRKTLETDSSSHSSVSRRGSINQGSLELIDKDDKLDTRSRNQLARFSSMESFKQVESRSS 738
L K + D + V GS + + D +D + N + + E+ S SS
Sbjct: 414 LVKADKQDQKENVPVKVSGSSSISKKDKTPPQDNVDKEAEN-VDKQEQKENLPAKASTSS 472
Query: 739 KKNKKLEFNSSRVSPVPNGGSQRGALNISKSFN----PVFGSSKKFFSASVPGSRIVSRA 794
KKNK P + + A N+ K P S+ + P
Sbjct: 473 KKNK----------TPPQDNADKEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEV 522
Query: 795 TSPISRRPSPPRSTTPTPTLGGLTT 819
++ P+P ++ P GG T
Sbjct: 523 EEESAQEPTPKKAKKPAAKRGGKKT 547
Score = 55.8 bits (133), Expect = 6e-07
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 1/125 (0%)
Query: 270 DVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACG 329
D+++IA G H ++T + G GRLG G DV+ I I V CG
Sbjct: 294 DIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCG 353
Query: 330 EYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTA 389
E + AVT+ G LY+WG+G N +G G+ + V+ +G H+ S G H
Sbjct: 354 EVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVV-VSKNTQGKHMLLASGGGQHAI 412
Query: 390 VVTSA 394
+ A
Sbjct: 413 FLVKA 417
>RCC1_SCHPO (P28745) Pim1 protein (Poly(A)+ RNA transport protein 2)
Length = 539
Score = 107 bits (267), Expect = 2e-22
Identities = 103/378 (27%), Positives = 173/378 (45%), Gaps = 61/378 (16%)
Query: 271 VQNIACGGRHAALVTKQGEIFSWGEESG---GRL--------GHGVDSDVLH---PKLID 316
V ++A GG H+A ++ G +++WG GRL G VD+D+L K+
Sbjct: 110 VVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEG 169
Query: 317 ALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWV-PKRVNGPLEG 375
ALS+ + V C + T A+T +G +TWG + G+LG+ + P ++ P
Sbjct: 170 ALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLP--- 226
Query: 376 IHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHG---DRKSVSLPREVESLKGLRTMR 432
+ ++ G H +T+ G+++T+G+G LG R+ L + +LK + ++
Sbjct: 227 -EICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVG 285
Query: 433 ASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLG---HGDKEAKLV--PTCV- 486
A G +H+ A+ + G+++ WG + G ++E ++ PT V
Sbjct: 286 A--GSYHSFAID------------NKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVD 331
Query: 487 ALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLP-TRVEGKLLKSF- 544
AL +N + G T+AL G V A G QLG P D LP T V+ + ++
Sbjct: 332 ALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIP--DNALPETVVKDEKGNNYY 389
Query: 545 ------------VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTD-DRNNPTLV-- 589
V ++ CG +H +T +VY+WG N +G GD D D PTLV
Sbjct: 390 LSTPTIIPGLTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRS 449
Query: 590 DALKDKHVKSIACGTNFT 607
A+K+ ++ G F+
Sbjct: 450 KAIKEVAIRVAGAGGQFS 467
Score = 88.2 bits (217), Expect = 1e-16
Identities = 87/300 (29%), Positives = 138/300 (46%), Gaps = 50/300 (16%)
Query: 341 DLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPL---EGIHVSYISCGPWHTAVVTSAGQL 397
++Y +G+G+ N LG G + V + P+ + + V ++ G H+A ++ G++
Sbjct: 72 NVYVFGSGSMNE--LGMGEEEMDVVYRPRLNPILSTDKVGVVDLAVGGMHSAALSHDGRV 129
Query: 398 FTFGDGTFGALG---------HGDRKSVSL----PREVE-SLKGLRTMRASCGVWHTAAV 443
+T+G ALG +GD+ L P +VE +L LR + C TAA+
Sbjct: 130 YTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAI 189
Query: 444 VEVMVGNSSSSNCSSGKLFTWGDG--DKGRLGHGDKEAKLV-PTCVALVEHNFCQVACGH 500
+ +G FTWG G LG+ D + + PT + L E CQ+A G
Sbjct: 190 TD------------NGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPE--ICQLATGT 235
Query: 501 SLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKL-----LKSFVEEIACGAYHV 555
+ALTT+G VY G+ QLG + + R++G LK+ + + G+YH
Sbjct: 236 DHIIALTTTGKVYTWGNGQQFQLGRRMLERR---RLQGLTPQPLALKNIIS-VGAGSYHS 291
Query: 556 AVLTLRNEVYTWGKGANGRLGHGDTDDRNN-----PTLVDALKDKHVKSIACGTNFTAAI 610
+ + VY WG + G D+ PTLVDAL+ +VKSI G + T A+
Sbjct: 292 FAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLAL 351
Score = 76.3 bits (186), Expect = 4e-13
Identities = 89/352 (25%), Positives = 143/352 (40%), Gaps = 46/352 (13%)
Query: 226 GDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSLF----PKALESAVV-LDVQNIACGGRH 280
G V+ WG D +G G K+D+ P +E A+ L V + C
Sbjct: 127 GRVYTWGVND-DYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNL 185
Query: 281 AALVTKQGEIFSWG--EESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTL 338
A +T G F+WG S G LG+ DS + + I +A G H A+T
Sbjct: 186 TAAITDNGCCFTWGTFRCSDGVLGYS-DSQKRTAEPTQ-MRLPEICQLATGTDHIIALTT 243
Query: 339 SGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLF 398
+G +YTWGNG LG + PL ++ + G +H+ + + G+++
Sbjct: 244 TGKVYTWGNG--QQFQLGRRMLERRRLQGLTPQPLALKNIISVGAGSYHSFAIDNKGRVY 301
Query: 399 TFGDGTFGALG-----HGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSS 453
+G G + ++ P V++L+G + G HT A++E
Sbjct: 302 AWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLE-------- 353
Query: 454 SNCSSGKLFTWGDGDKGRLGHGD--------KEAK------LVPTCVALVEHNFCQVACG 499
G++ WG D+ +LG D K+ K PT + + N QV CG
Sbjct: 354 ----DGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLT-NVIQVVCG 408
Query: 500 HSLTVALTTSGHVYAMGSPVYGQL--GNPQADGKLPTRVEGKLLKSFVEEIA 549
+A+T+ G VY+ GS ++ G+ D +PT V K +K +A
Sbjct: 409 THHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEVAIRVA 460
Score = 37.4 bits (85), Expect = 0.22
Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 1/61 (1%)
Query: 270 DVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHG-VDSDVLHPKLIDALSNTNIELVAC 328
+V + CG H VT G+++SWG +G G D DV P L+ + + + +
Sbjct: 401 NVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEVAIRVA 460
Query: 329 G 329
G
Sbjct: 461 G 461
>GNFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related
protein (Deafness locus associated putative guanine
nucleotide exchange factor) (DelGEF)
Length = 464
Score = 105 bits (261), Expect = 8e-22
Identities = 104/394 (26%), Positives = 164/394 (41%), Gaps = 36/394 (9%)
Query: 242 GGNHRVGSGLGVKIDSLFPKALESAVVLD-VQNIACGGRHAALVTKQGEIFSWGEESGGR 300
G N GLG K D P+ L ++++ GG H+A+VT G++F G G+
Sbjct: 21 GANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQ 80
Query: 301 LGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQ 360
LG G +VL + L I VACG T +T G + + G+ A+ + HG +
Sbjct: 81 LGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPR 140
Query: 361 VSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPR 420
VP+ + E V ++ G H T+ G +F +G G + G +LP
Sbjct: 141 -KCVVPQAIECLRE--KVVCVAAGLRHALATTATGSVFQWGTG-LASSGRRLCPGQNLPL 196
Query: 421 EVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAK 480
+ + + R G+ ++ AV V + S+S +G+L+ WG G+L A
Sbjct: 197 FLTAKEPSRV----TGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA---SRAV 249
Query: 481 LVPTCVALVEHNF-----CQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTR 535
+P + H F V G + VA T +G V+ G YGQLG +
Sbjct: 250 FLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKP 309
Query: 536 VEGKLLKSF----------------VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGD 579
VE +F EI+CG+ H + +R++ +WG +G G G
Sbjct: 310 VEQDSSLAFQGPQNSVPSPLHCLTGATEISCGSEH-NLAVIRDKCCSWGWNEHGMCGDGT 368
Query: 580 TDDRNNPTLVDAL--KDKHVKSIACGTNFTAAIC 611
+ PT V AL + + CG + A+C
Sbjct: 369 ESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVC 402
Score = 103 bits (256), Expect = 3e-21
Identities = 91/306 (29%), Positives = 139/306 (44%), Gaps = 31/306 (10%)
Query: 284 VTKQGEIFSWGEESGGRLGHGVDSDVLHP-KLIDALSNTNIELVACGEYHTCAVTLSGDL 342
V+ +F+WG S G+LG G DV P +L D I+ V G H+ VT GDL
Sbjct: 11 VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDL 70
Query: 343 YTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGD 402
+ G LGH +V + + PL G + ++CG T ++T GQ+ + G
Sbjct: 71 FVCGLNKDGQLGLGHTEEVLRFT---ICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGS 127
Query: 403 GTFGALG--HGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGK 460
FG LG HG RK V +P+ +E L+ + + + G+ H A ++G
Sbjct: 128 NAFGQLGVPHGPRKCV-VPQAIECLRE-KVVCVAAGLRHALATT------------ATGS 173
Query: 461 LFTWGDG--DKGRLGHGDKEAKLV-----PTCVALVEHN--FCQVACGHSLTVALTTSGH 511
+F WG G GR + L P+ V +E++ C VA G + +LT +G
Sbjct: 174 VFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVA-GSDHSASLTDTGE 232
Query: 512 VYAMGSPVYGQLGNPQADGKLPTRVEGKLLK-SFVEEIACGAYHVAVLTLRNEVYTWGKG 570
+Y G +GQL + LP R+E + V + G H+ T +V+TWG+
Sbjct: 233 LYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRA 292
Query: 571 ANGRLG 576
G+LG
Sbjct: 293 DYGQLG 298
Score = 78.2 bits (191), Expect = 1e-13
Identities = 69/233 (29%), Positives = 97/233 (41%), Gaps = 20/233 (8%)
Query: 391 VTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGN 450
V++A LF +G ++G LG G ++ V LP+++ +++ G +AVV
Sbjct: 11 VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVT----- 65
Query: 451 SSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPT-CVALVEHNFCQVACGHSLTVALTTS 509
G LF G G+LG G E L T C L QVACG T+ LT
Sbjct: 66 ------DGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEK 119
Query: 510 GHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEVYTWGK 569
G V + GS +GQLG P K + L+ V +A G H T V+ WG
Sbjct: 120 GQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGT 179
Query: 570 GANGRLGHGDTDDRNNPTLVDALKDKHVKSIACGTNFTAAICLHKWVSGVDQS 622
G G +N P + A + V G + A+C V+G D S
Sbjct: 180 GL-ASSGRRLCPGQNLPLFLTAKEPSRV----TGLENSTAVCA---VAGSDHS 224
Score = 61.2 bits (147), Expect = 1e-08
Identities = 55/195 (28%), Positives = 88/195 (44%), Gaps = 21/195 (10%)
Query: 451 SSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQVACGHSLT------V 504
+S + ++ LF WG G+LG G KE +P ++ +FCQ C S+T
Sbjct: 7 ASETVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLS----DFCQAGCIKSVTGGGGHSA 62
Query: 505 ALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEV 564
+T G ++ G GQLG + L + L + ++ACG +LT + +V
Sbjct: 63 VVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQV 122
Query: 565 YTWGKGANGRLG--HGDTDDRNNPTLVDALKDKHVKSIACGTNF----TAAICLHKWVSG 618
+ G A G+LG HG P ++ L++K V +A G TA + +W +G
Sbjct: 123 LSCGSNAFGQLGVPHGPR-KCVVPQAIECLREK-VVCVAAGLRHALATTATGSVFQWGTG 180
Query: 619 VDQS---MCSGCRLP 630
+ S +C G LP
Sbjct: 181 LASSGRRLCPGQNLP 195
>GNFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related
protein (Deafness locus associated putative guanine
nucleotide exchange factor) (DelGEF)
Length = 458
Score = 103 bits (258), Expect = 2e-21
Identities = 88/299 (29%), Positives = 134/299 (44%), Gaps = 29/299 (9%)
Query: 290 IFSWGEESGGRLGHGVDSDVLHP-KLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNG 348
+F+WG S G+LG G DVL P +L D ++ + G H+ VT GDL+ G
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 349 AYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGAL 408
LGH + ++ P + L G + ++CG T ++T GQ+ + G +FG L
Sbjct: 77 KDGQLGLGHTEDIPYFTPCK---SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQL 133
Query: 409 G--HGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGD 466
G HG R+ V +P+ +E L + + + G+ H A +SG +F WG
Sbjct: 134 GVPHGPRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAAT------------ASGIVFQWGT 179
Query: 467 GDKG---RLGHGDK-----EAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSP 518
G RL G AK L V G + +LT +G VY GS
Sbjct: 180 GLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSN 239
Query: 519 VYGQLGNPQADGKLPTRVEGKLLKS-FVEEIACGAYHVAVLTLRNEVYTWGKGANGRLG 576
+GQL N A +P ++E ++ V I G H+ T +++TWG+ G+LG
Sbjct: 240 KHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG 298
Score = 103 bits (257), Expect = 2e-21
Identities = 105/398 (26%), Positives = 166/398 (41%), Gaps = 46/398 (11%)
Query: 242 GGNHRVGSGLGVKIDSLFPKALES-AVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGR 300
G N GLG K D L P+ L V+ I GG H+A+VT G++F G G+
Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
Query: 301 LGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQ 360
LG G D+ + +L I+ VACG T +T +G + + G+ ++ + HG +
Sbjct: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPR 140
Query: 361 VSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLP- 419
VP+ + L V I+ G H T++G +F +G G + G +LP
Sbjct: 141 -RCVVPQAIE--LHKEKVVCIAAGLRHAVAATASGIVFQWGTG-LASCGRRLCPGQTLPL 196
Query: 420 ----REVESLKGLRTMRASCGVWHTAAVVEVMVGNS-SSSNCSSGKLFTWGDGDKGRLGH 474
+E + GL +A C V+ G+ S+S +G+++ WG G+L +
Sbjct: 197 FFTAKEPSRVTGLENSKAMC----------VLAGSDHSASLTDAGEVYVWGSNKHGQLAN 246
Query: 475 GDKEAKLVPTCVALVEHNF-----CQVACGHSLTVALTTSGHVYAMGSPVYGQLGN---- 525
EA +P + H F + G + VA T +G ++ G YGQLG
Sbjct: 247 ---EAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLET 303
Query: 526 ------PQADGKLPTRVEGKLLKSF------VEEIACGAYHVAVLTLRNEVYTWGKGANG 573
+ D LP + S E++CG+ H + + Y+WG +G
Sbjct: 304 YEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHG 362
Query: 574 RLGHGDTDDRNNPTLVDALKDKHVKSIACGTNFTAAIC 611
G G + P V AL + CG + A+C
Sbjct: 363 MCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALC 400
Score = 84.0 bits (206), Expect = 2e-15
Identities = 75/253 (29%), Positives = 112/253 (43%), Gaps = 26/253 (10%)
Query: 335 AVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSA 394
A + L+ WG A +YG LG G++ +P+++N + V I+ G H+AVVT
Sbjct: 10 AAPAAAALFAWG--ANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
Query: 395 GQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSS 454
G LF G G LG G + + +SL G + +CG T + E
Sbjct: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTE--------- 118
Query: 455 NCSSGKLFTWGDGDKGRLG--HGDKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHV 512
+G++ + G G+LG HG + +VP + L + +A G VA T SG V
Sbjct: 119 ---NGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIV 174
Query: 513 YAMGSPVY--------GQLGNPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEV 564
+ G+ + GQ K P+RV G L S + G+ H A LT EV
Sbjct: 175 FQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTG-LENSKAMCVLAGSDHSASLTDAGEV 233
Query: 565 YTWGKGANGRLGH 577
Y WG +G+L +
Sbjct: 234 YVWGSNKHGQLAN 246
Score = 79.7 bits (195), Expect = 4e-14
Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 19/234 (8%)
Query: 385 PWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVV 444
P + +A LF +G ++G LG G ++ V LP+++ R++R G +AVV
Sbjct: 5 PSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVV 64
Query: 445 EVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKE-AKLVPTCVALVEHNFCQVACGHSLT 503
G LF G G+LG G E C +L QVACG T
Sbjct: 65 T-----------DGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFT 113
Query: 504 VALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNE 563
+ LT +G V + GS +GQLG P + +L K V IA G H T
Sbjct: 114 IMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGI 173
Query: 564 VYTWGKG---ANGRLGHGDT----DDRNNPTLVDALKDKHVKSIACGTNFTAAI 610
V+ WG G RL G T P+ V L++ + G++ +A++
Sbjct: 174 VFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASL 227
Score = 62.4 bits (150), Expect = 6e-09
Identities = 61/245 (24%), Positives = 103/245 (41%), Gaps = 34/245 (13%)
Query: 224 ALGDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSLFPKALESAVVLDVQN-----IACGG 278
A G VF WG G + R+ G + LF A E + V ++N + G
Sbjct: 170 ASGIVFQWGTG-----LASCGRRLCPGQTLP---LFFTAKEPSRVTGLENSKAMCVLAGS 221
Query: 279 RHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDA--LSNTNIELVACGEYHTCAV 336
H+A +T GE++ WG G+L + + + P+ I+A N + + G H A
Sbjct: 222 DHSASLTDAGEVYVWGSNKHGQLANEA-AFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQ 280
Query: 337 TLSGDLYTWGNGAYNYGLLGHGNQV---------SHWVP--KRVNGPLEGIH----VSYI 381
T +G ++TWG +YG LG + ++P + N H + +
Sbjct: 281 TETGKMFTWGRA--DYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEV 338
Query: 382 SCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTA 441
SCG H + G +++G G G G +V P+ V++L + CG H+
Sbjct: 339 SCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSL 397
Query: 442 AVVEV 446
A+ ++
Sbjct: 398 ALCQL 402
>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Cell
cycle regulatory protein)
Length = 421
Score = 98.2 bits (243), Expect = 1e-19
Identities = 98/391 (25%), Positives = 170/391 (43%), Gaps = 47/391 (12%)
Query: 250 GLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGH--GVDS 307
GLG + AL S + DV GG H ++K G+++S+G G LG V+
Sbjct: 49 GLGENVMERKKPALVS-IPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEG 107
Query: 308 DVLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSH-WVP 366
+ P ++ + V+ G+ HT A+T G ++ WG+ N G++G + VP
Sbjct: 108 SEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVP 165
Query: 367 KRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGH--------GDRKSVS- 417
+V + V ++ G H ++T+ G L+T G G G LG G R+ +
Sbjct: 166 VQVQ---LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLER 222
Query: 418 --LPREVE-----SLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKG 470
+P+ V S +R A CG + T A+ G ++ +G +
Sbjct: 223 LLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISH------------EGHVYGFGLSNYH 270
Query: 471 RLGHGDKEAKLVPTCVALVEHN---FCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQ 527
+LG E+ +P + +++ + + G TV + + G Y++G YG+LG +
Sbjct: 271 QLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGE 330
Query: 528 A--DGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNN 585
+ +PT + V +ACGA +T V+ WG G N +LG G +D +
Sbjct: 331 GAEEKSIPTLISRL---PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWS 387
Query: 586 PT--LVDALKDKHVKSIACGTNFTAAICLHK 614
P + L+++ V S++ G T + K
Sbjct: 388 PVEMMGKQLENRVVLSVSSGGQHTVLLVKDK 418
Score = 55.5 bits (132), Expect = 8e-07
Identities = 39/129 (30%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 453 SSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHV 512
S + G + T G GD G+LG G+ + + + + Q G TV L+ SG V
Sbjct: 29 SHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQV 88
Query: 513 YAMGSPVYGQLG---NPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEVYTWG- 568
Y+ G G LG + + +P +VE L+ V +++ G H A LT V+ WG
Sbjct: 89 YSFGCNDEGALGRDTSVEGSEMVPGKVE---LQEKVVQVSAGDSHTAALTDDGRVFLWGS 145
Query: 569 -KGANGRLG 576
+ NG +G
Sbjct: 146 FRDNNGVIG 154
>RCC1_MESAU (P23800) Regulator of chromosome condensation
Length = 421
Score = 94.7 bits (234), Expect = 1e-18
Identities = 105/378 (27%), Positives = 162/378 (42%), Gaps = 55/378 (14%)
Query: 280 HAALVTKQGEIFSWGEESGGRLGHGVDSDVLH---PKLIDALSNTNIELVACGEYHTCAV 336
H + T+ G + + G+ G+LG G VL P L+ L + + G HT +
Sbjct: 27 HRSHKTEPGLVLTLGQGDVGQLGLG--ESVLERKKPALVPLLQD--VVQAEAGGMHTVCL 82
Query: 337 TLSGDLYTWGNGAYNYGLLGHGNQV--SHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSA 394
SG +Y++G + G LG V S VP +V + + VS G HTA +T
Sbjct: 83 NQSGQVYSFG--CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVS---AGDSHTAALTED 137
Query: 395 GQLFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSS 454
G++F +G D V + L+ ++ V VV+V GN
Sbjct: 138 GRVFLWGS-------FRDNNGV-----IGLLEPMKKSMVPVQVQLDMPVVKVASGNDHLV 185
Query: 455 NCSS-GKLFTWGDGDKGRLGHGDK-----------EAKLVPTCVALVEHN------FCQV 496
++ G L+T G G++G+LG + E LVP CV L F
Sbjct: 186 MLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVLLKSRGSRGRVRFQDA 245
Query: 497 ACGHSLTVALTTSGHVYAMGSPVYGQLGNP-QADGKLPTRVEG--KLLKSFVEEIACGAY 553
CG LT A++ GHVY G Y QLG P A +P + KS+V + G +
Sbjct: 246 FCGAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWV-GFSGGQH 304
Query: 554 HVAVLTLRNEVYTWGKGANGRLGHGD-TDDRNNPTLVDALKDKHVKSIACGTNFTAAIC- 611
H + + Y+ G+ GRLG G+ ++++ PTL+ L V S+ACG + A+
Sbjct: 305 HTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSK 362
Query: 612 ---LHKWVSGVDQSMCSG 626
+ W G + + +G
Sbjct: 363 DGRVFAWGMGTNYQLGTG 380
Score = 89.7 bits (221), Expect = 4e-17
Identities = 86/371 (23%), Positives = 159/371 (42%), Gaps = 46/371 (12%)
Query: 270 DVQNIACGGRHAALVTKQGEIFSWGEESGGRLGH--GVDSDVLHPKLIDALSNTNIELVA 327
DV GG H + + G+++S+G G LG V+ + P ++ + V+
Sbjct: 68 DVVQAEAGGMHTVCLNQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL--QEKVVQVS 125
Query: 328 CGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSH-WVPKRVNGPLEGIHVSYISCGPW 386
G+ HT A+T G ++ WG+ N G++G + VP +V + + V+ G
Sbjct: 126 AGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDMPVVKVA---SGND 182
Query: 387 HTAVVTSAGQLFTFGDGTFGALGH--------GDRKSVS--------LPREVESLKGLRT 430
H ++T+ G L+T G G G LG G R+ + L + S +R
Sbjct: 183 HLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVLLKSRGSRGRVRF 242
Query: 431 MRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVE 490
A CG + T A+ G ++ +G + +LG + +P + +
Sbjct: 243 QDAFCGAYLTFAISR------------EGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFK 290
Query: 491 HN---FCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQA--DGKLPTRVEGKLLKSFV 545
++ + + G T+ + + G Y++G YG+LG + + +PT + + V
Sbjct: 291 NSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPV---V 347
Query: 546 EEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDA--LKDKHVKSIACG 603
+ACGA ++ V+ WG G N +LG G +D +P + L+++ V +++ G
Sbjct: 348 SSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSG 407
Query: 604 TNFTAAICLHK 614
T + K
Sbjct: 408 GQHTVLLVKDK 418
Score = 42.0 bits (97), Expect = 0.009
Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 5/90 (5%)
Query: 246 RVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGV 305
R+G G G + S+ P + V V ++ACG V+K G +F+WG + +LG G
Sbjct: 325 RLGLGEGAEEKSI-PTLISRLPV--VSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQ 381
Query: 306 DSDVLHPKLIDA--LSNTNIELVACGEYHT 333
D D P + L N + V+ G HT
Sbjct: 382 DEDAWSPVEMTGKQLENRVVLTVSSGGQHT 411
>RCC1_XENLA (P25183) Regulator of chromosome condensation
Length = 424
Score = 90.5 bits (223), Expect = 2e-17
Identities = 100/374 (26%), Positives = 159/374 (41%), Gaps = 48/374 (12%)
Query: 280 HAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNT-NIELVACGEYHTCAVTL 338
H + T G++ + G+ G+LG G D++ K ++ T +I A G HT +
Sbjct: 33 HPSHGTVGGQVLTLGQGDVGQLGLG--EDIMERKKPALVTLTEDIVQAAAGGMHTVCLGA 90
Query: 339 SGDLYTWGNGAYNYGLLGH--GNQVSHWVPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQ 396
SG +YT+G + G LG + S P +V + + VS G HTA +T G+
Sbjct: 91 SGSIYTFG--CNDEGALGRDTSEEGSEMQPGKVELAEKVVQVS---AGDSHTAALTEDGR 145
Query: 397 LFTFGDGTFGALGHGDRKSVSLPREVESLKGLRTMRASCGVWHTAAVVEVMVGNSSSSNC 456
+F FG D V + L+ ++ V V+++ GN
Sbjct: 146 VFVFGS-------FRDNNGV-----IGLLEPMKKSMVPVQVQINTPVIKIASGNDHLVLL 193
Query: 457 S-SGKLFTWGDGDKGRLGH---------GDK--EAKLVPTCVALVEH-----NFCQVACG 499
+ G L+T G G++G+LG G K E LVP C+ L +F V CG
Sbjct: 194 TVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGSGRVHFQDVFCG 253
Query: 500 HSLTVALTTSGHVYAMGSPVYGQLG--NPQADGKLPTRVEGKLLKSFVEEIACGAYHVAV 557
T A++ GHVY G Y QLG N QA K + G +H
Sbjct: 254 AYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVC 313
Query: 558 LTLRNEVYTWGKGANGRLGHGD-TDDRNNPTLVDALKDKHVKSIACGTNFTAAI----CL 612
+ + Y+ G+ GRLG G+ ++++ PT + L + S+A G + + A+ C+
Sbjct: 314 VDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDL--PKINSVASGASVSYAVSTDGCV 371
Query: 613 HKWVSGVDQSMCSG 626
W G + + +G
Sbjct: 372 FAWGMGTNLQLGTG 385
Score = 83.6 bits (205), Expect = 3e-15
Identities = 104/407 (25%), Positives = 173/407 (41%), Gaps = 58/407 (14%)
Query: 238 GVVGG-----GNHRVGS-GLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIF 291
G VGG G VG GLG I AL + + D+ A GG H + G I+
Sbjct: 37 GTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVT-LTEDIVQAAAGGMHTVCLGASGSIY 95
Query: 292 SWGEESGGRLGHGVDSD--VLHPKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGA 349
++G G LG + + P ++ + V+ G+ HT A+T G ++ +G+
Sbjct: 96 TFGCNDEGALGRDTSEEGSEMQPGKVELAEK--VVQVSAGDSHTAALTEDGRVFVFGSFR 153
Query: 350 YNYGLLGHGNQVSHW---VPKRVNGPLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFG 406
N G++G + V ++N P V I+ G H ++T G L+T G G G
Sbjct: 154 DNNGVIGLLEPMKKSMVPVQVQINTP-----VIKIASGNDHLVLLTVDGDLYTSGCGEQG 208
Query: 407 ALGH--------GDRKSVS--LPREVESLKGLRTMRAS-----CGVWHTAAVVEVMVGNS 451
LG G RK + L + LK + R CG + T AV +
Sbjct: 209 QLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGSGRVHFQDVFCGAYFTFAVSQ------ 262
Query: 452 SSSNCSSGKLFTWGDGDKGRLGHGDKEAKLVPTCVALVEHN---FCQVACGHSLTVALTT 508
G ++ +G + +LG + +A P + +++ + + G TV + +
Sbjct: 263 ------EGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVCVDS 316
Query: 509 SGHVYAMGSPVYGQLG---NPQADGKLPTRVEGKLLKSFVEEIACGAYHVAVLTLRNEVY 565
G Y++G YG+LG N + + PT + L K + +A GA ++ V+
Sbjct: 317 EGKAYSLGRAEYGRLGLGENAEEQSE-PTPIPD-LPK--INSVASGASVSYAVSTDGCVF 372
Query: 566 TWGKGANGRLGHGDTDDRNNPTLVDA--LKDKHVKSIACGTNFTAAI 610
WG G N +LG G+ +D +P + L+D+ V S++ G T +
Sbjct: 373 AWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQHTVLL 419
Score = 51.2 bits (121), Expect = 1e-05
Identities = 47/164 (28%), Positives = 71/164 (42%), Gaps = 16/164 (9%)
Query: 425 LKGLRTMRASCGVWHTAAVVEVM------VGNSSSSNCSSGKLFTWGDGDKGRLGHG-DK 477
+KG +T++ + + +V + S G++ T G GD G+LG G D
Sbjct: 1 MKGKKTLKRTIAAEESNGTSDVKKTKALPIVTHPSHGTVGGQVLTLGQGDVGQLGLGEDI 60
Query: 478 EAKLVPTCVALVEHNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLG---NPQADGKLPT 534
+ P V L E + Q A G TV L SG +Y G G LG + + P
Sbjct: 61 MERKKPALVTLTE-DIVQAAAGGMHTVCLGASGSIYTFGCNDEGALGRDTSEEGSEMQPG 119
Query: 535 RVEGKLLKSFVEEIACGAYHVAVLTLRNEVYTWG--KGANGRLG 576
+VE L V +++ G H A LT V+ +G + NG +G
Sbjct: 120 KVE---LAEKVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIG 160
>WS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16
protein homolog
Length = 461
Score = 87.4 bits (215), Expect = 2e-16
Identities = 95/379 (25%), Positives = 156/379 (41%), Gaps = 42/379 (11%)
Query: 202 FRVSLSSAVSSSSQGSGHD--DGDALGDVFIWGEGTG-DGVVGGGNHRVGSGLGVKI--- 255
+R+ L +SS++ G G +WG G D +G R G +
Sbjct: 98 YRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLE 157
Query: 256 DSLFPKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPK-- 313
S P L+ V ++CG H+ ++T + +FS G S G+ G V D ++ +
Sbjct: 158 PSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESH 217
Query: 314 LIDALSNTN--IELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNG 371
+ + + + + V CG+ H+ +T G++Y+ G GA LGH N S P ++ G
Sbjct: 218 KVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS--TPSKLGG 275
Query: 372 PLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGH-GDRKSVSLPREVESLKGLRT 430
L G+ V ++ +++ G +F +G+ + L D V++PR + +
Sbjct: 276 DLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKV 335
Query: 431 MRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDK------EAKLVPT 484
+ +CG G + + G +F WG G LG G K + PT
Sbjct: 336 KQVACG------------GTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPT 380
Query: 485 CVALVEHN----FCQVACGHSLTVALTTSGHVYAMGSPVYGQLG-NPQADGKLPTRVEGK 539
L E N Q+ CG S ALT G ++ G + G LG D P RV
Sbjct: 381 LFGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--- 437
Query: 540 LLKSFVEEIACGAYHVAVL 558
+ ++ACG H+ L
Sbjct: 438 TMPGEPVDVACGVDHMVTL 456
Score = 80.9 bits (198), Expect = 2e-14
Identities = 77/312 (24%), Positives = 126/312 (39%), Gaps = 40/312 (12%)
Query: 312 PKLIDALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNG 371
P +D T + V+CG H+ +T +++ GN + HG V V
Sbjct: 162 PLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNS-------HGQCGRKVVEDEVYS 214
Query: 372 PLEGIH--------VSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVE 423
+H V + CG H+ +T G++++ G G G G G S P ++
Sbjct: 215 ESHKVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLG 274
Query: 424 S-LKGLRTMRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKL- 481
L G+ ++ + G+ + + G +F WG+ + +L ++
Sbjct: 275 GDLAGVTVVQVAT------------YGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVN 322
Query: 482 VPTCVALVE-HNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKL 540
VP C+ QVACG + L GHV+ G + G+ G + +P + L
Sbjct: 323 VPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWGYGILGK-GPKLLETAIPEMIPPTL 381
Query: 541 --LKSF-----VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALK 593
L F V +I CG H A LT + E++ WGK G LG G +D+ P V
Sbjct: 382 FGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPG 441
Query: 594 DKHVKSIACGTN 605
+ +ACG +
Sbjct: 442 EP--VDVACGVD 451
Score = 57.4 bits (137), Expect = 2e-07
Identities = 43/144 (29%), Positives = 68/144 (46%), Gaps = 17/144 (11%)
Query: 260 PKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHG---VDSDV--LHPKL 314
P+ L + V V+ +ACGG A++ +G +F WG G LG G +++ + + P
Sbjct: 324 PRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWGY---GILGKGPKLLETAIPEMIPPT 380
Query: 315 IDALSNTNIEL----VACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVN 370
+ L+ N E+ + CG H A+T G+L+ WG G LG G + P RV
Sbjct: 381 LFGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNI--RGCLGIGRLEDQYFPWRVT 438
Query: 371 GPLEGIHVSYISCGPWHTAVVTSA 394
P E + V +CG H + +
Sbjct: 439 MPGEPVDV---ACGVDHMVTLAKS 459
Score = 47.0 bits (110), Expect = 3e-04
Identities = 37/124 (29%), Positives = 55/124 (43%), Gaps = 6/124 (4%)
Query: 216 GSGHDDGDALGDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIA 275
G+G +A G VF+WG G ++G G + + + I E + V I
Sbjct: 342 GTGCAVLNAEGHVFVWGYG----ILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIR 397
Query: 276 CGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCA 335
CG H A +T +GE+F WG+ G LG G D P + + ++ VACG H
Sbjct: 398 CGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHMVT 455
Query: 336 VTLS 339
+ S
Sbjct: 456 LAKS 459
>WS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16
protein
Length = 464
Score = 81.3 bits (199), Expect = 1e-14
Identities = 91/364 (25%), Positives = 150/364 (41%), Gaps = 47/364 (12%)
Query: 271 VQNIACGGRHAALVTKQGEI---FSWGEESGGRLG-HGVDSD-------VLHPKLI---- 315
+ + ACG L +K ++ + G +LG H D VL P +
Sbjct: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168
Query: 316 DALSNTNIELVACGEYHTCAVTLSGDLYTWGNGAYNY-GLLGHGNQV---SHWVPKRVNG 371
D T + V+CG H+ +T +++ GN +Y G N++ SH V + +
Sbjct: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD- 227
Query: 372 PLEGIHVSYISCGPWHTAVVTSAGQLFTFGDGTFGALGHGDRKSVSLPREVES-LKGLRT 430
+G V ++CG H+ +T G++++ G G G G G S P ++ L G+
Sbjct: 228 -FDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285
Query: 431 MRASCGVWHTAAVVEVMVGNSSSSNCSSGKLFTWGDGDKGRLGHGDKEAKL-VPTCVALV 489
++ + G+ + + G LF WG+ + +L ++ VP C+
Sbjct: 286 IQVAT------------YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 333
Query: 490 E-HNFCQVACGHSLTVALTTSGHVYAMGSPVYGQLGNPQADGKLPTRVEGKL--LKSF-- 544
Q ACG + L GHV+ G + G+ G + +P + L L F
Sbjct: 334 GVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNP 392
Query: 545 ---VEEIACGAYHVAVLTLRNEVYTWGKGANGRLGHGDTDDRNNPTLVDALKDKHVKSIA 601
V I CG H A LT + E++ WGK G LG G +D+ P V + +A
Sbjct: 393 EIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP--VDVA 450
Query: 602 CGTN 605
CG +
Sbjct: 451 CGVD 454
Score = 59.3 bits (142), Expect = 5e-08
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 11/141 (7%)
Query: 260 PKALESAVVLDVQNIACGGRHAALVTKQGEIFSWGEESGGRLGHGVDSDV--LHPKLIDA 317
P+ L + V V+ ACGG A++ +G +F WG G+ + V+S V + P +
Sbjct: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG 386
Query: 318 LSNTNIEL----VACGEYHTCAVTLSGDLYTWGNGAYNYGLLGHGNQVSHWVPKRVNGPL 373
L+ N E+ + CG H A+T G+L+ WG G LG G + P RV P
Sbjct: 387 LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNI--RGCLGIGRLEDQYFPWRVTMPG 444
Query: 374 EGIHVSYISCGPWHTAVVTSA 394
E + V +CG H + +
Sbjct: 445 EPVDV---ACGVDHMVTLAKS 462
Score = 48.9 bits (115), Expect = 7e-05
Identities = 36/114 (31%), Positives = 51/114 (44%), Gaps = 6/114 (5%)
Query: 226 GDVFIWGEGTGDGVVGGGNHRVGSGLGVKIDSLFPKALESAVVLDVQNIACGGRHAALVT 285
G VF+WG G ++G G + V S + I E + V I CG H A +T
Sbjct: 355 GHVFVWGYG----ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410
Query: 286 KQGEIFSWGEESGGRLGHGVDSDVLHPKLIDALSNTNIELVACGEYHTCAVTLS 339
+GE+F WG+ G LG G D P + + ++ VACG H + S
Sbjct: 411 NKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHMVTLAKS 462
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.313 0.130 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 127,946,276
Number of Sequences: 164201
Number of extensions: 5750901
Number of successful extensions: 19577
Number of sequences better than 10.0: 274
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 18157
Number of HSP's gapped (non-prelim): 916
length of query: 1061
length of database: 59,974,054
effective HSP length: 121
effective length of query: 940
effective length of database: 40,105,733
effective search space: 37699389020
effective search space used: 37699389020
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 71 (32.0 bits)
Medicago: description of AC146692.2