BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= AC146681.9 + phase: 2 /pseudo
         (249 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

RINI_PIG (P10775) Ribonuclease inhibitor                               43  6e-04
RINI_PANTR (Q8HZP9) Placental ribonuclease inhibitor (Ribonuclea...    39  0.009
RINI_HUMAN (P13489) Placental ribonuclease inhibitor (Ribonuclea...    39  0.012
NA12_HUMAN (P59046) NACHT-, LRR- and PYD-containing protein 12 (...    39  0.012
NAL5_MOUSE (Q9R1M5) NACHT-, LRR- and PYD-containing protein 5 (M...    38  0.020
NAL1_HUMAN (Q9C000) NACHT-, LRR- and PYD-containing protein 2 (D...    38  0.020
NAL2_HUMAN (Q9NX02) NACHT-, LRR- and PYD-containing protein 2 (P...    38  0.026
NA14_HUMAN (Q86W24) NACHT-, LRR- and PYD-containing protein 14 (...    35  0.13
NAL5_HUMAN (P59047) NACHT-, LRR- and PYD-containing protein 5 (M...    35  0.17
C2TA_MOUSE (P79621) MHC class II transactivator (CIITA)                35  0.22
RINI_RAT (P29315) Ribonuclease inhibitor                               34  0.38
CAR4_HUMAN (Q9Y239) Caspase recruitment domain protein 4 (Nod1 p...    34  0.38
C2TA_HUMAN (P33076) MHC class II transactivator (CIITA)                34  0.38
CIS1_MOUSE (Q8R4B8) Cold autoinflammatory syndrome 1 protein hom...    32  1.1
FXL3_MOUSE (Q8C4V4) F-box/LRR-repeat protein 3 (F-box/LRR-repeat...    32  1.4
FXL3_HUMAN (Q9UKT7) F-box/LRR-repeat protein 3 (F-box/LRR-repeat...    32  1.4
HMD1_ORYSA (P48019) 3-hydroxy-3-methylglutaryl-coenzyme A reduct...    32  1.9
CYAA_NEUCR (Q01631) Adenylate cyclase (EC 4.6.1.1) (ATP pyrophos...    32  1.9
CIS1_HUMAN (Q96P20) Cold autoinflammatory syndrome 1 protein (Cr...    32  1.9
HMD2_DICDI (P34136) 3-hydroxy-3-methylglutaryl-coenzyme A reduct...    31  3.2

>RINI_PIG (P10775) Ribonuclease inhibitor
          Length = 456

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 51/184 (27%), Positives = 77/184 (41%), Gaps = 16/184 (8%)

Query: 46  AYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSL 105
           A   +L +LD+  N + D G+  L P   G     SRL  L L  CD++      L   L
Sbjct: 219 ASQASLRELDLGSNGLGDAGIAELCP---GLLSPASRLKTLWLWECDITASGCRDLCRVL 275

Query: 106 PVLNGTLKSLSIAENCLGSKVAGALGRFLSTP---IEVLDASGIDLLPSGFLELQNMLTI 162
                TLK LS+A N LG + A  L   L  P   +E L      L  +    +  MLT 
Sbjct: 276 QA-KETLKELSLAGNKLGDEGARLLCESLLQPGCQLESLWVKSCSLTAACCQHVSLMLT- 333

Query: 163 EEELSLVIINISKNRGGIQTARFLSKLLPQAPRLVDV-------NASSNCMPIESLSIIS 215
            +   L+ + +S N+ G    + L + L Q    + V         +S C  + SL + +
Sbjct: 334 -QNKHLLELQLSSNKLGDSGIQELCQALSQPGTTLRVLCLGDCEVTNSGCSSLASLLLAN 392

Query: 216 SALK 219
            +L+
Sbjct: 393 RSLR 396



 Score = 37.7 bits (86), Expect = 0.026
 Identities = 44/179 (24%), Positives = 76/179 (41%), Gaps = 15/179 (8%)

Query: 33  LRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACD 92
           L ++  +++G A    P+L +L +  N + D G+  ++    G      ++  L L+ C 
Sbjct: 35  LTEEHCKDIGSALRANPSLTELCLRTNELGDAGVHLVL---QGLQSPTCKIQKLSLQNCS 91

Query: 93  LS---CDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTP---IEVLDASGI 146
           L+   C V+   L SLP    TL+ L +++N LG      L   L  P   +E L     
Sbjct: 92  LTEAGCGVLPSTLRSLP----TLRELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLEYC 147

Query: 147 DLLPSGFLELQNMLTIEEELSLVIINISKNRGGIQTARFLSKLLPQAPRLVDVNASSNC 205
            L  +    L ++L      +L  + +S N  G   AR L + L  +   ++     NC
Sbjct: 148 RLTAASCEPLASVLRATR--ALKELTVSNNDIGEAGARVLGQGLADSACQLETLRLENC 204


>RINI_PANTR (Q8HZP9) Placental ribonuclease inhibitor
           (Ribonuclease/angiogenin inhibitor) (RAI) (RNase
           inhibitor) (RI)
          Length = 460

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 42/162 (25%), Positives = 70/162 (42%), Gaps = 9/162 (5%)

Query: 32  NLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEAC 91
           NL     + L       P+ ++L +S+N I + G+R L     G  +   +L  LKLE+C
Sbjct: 152 NLSAASCKPLASVLRAKPDFKELTVSNNDINEAGVRVLC---QGLKDSPCQLEALKLESC 208

Query: 92  DLSCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGI---DL 148
            ++ D    L   +     +L+ L++  N LG      L   L  P   L    I    +
Sbjct: 209 GVTSDNCRDLC-GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 267

Query: 149 LPSGFLELQNMLTIEEELSLVIINISKNRGGIQTARFLSKLL 190
              G  +L  +L  +E  SL  ++++ N  G + AR L + L
Sbjct: 268 TAKGCGDLCRVLRAKE--SLKELSLAGNELGDEGARLLCETL 307



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 42/184 (22%), Positives = 79/184 (42%), Gaps = 37/184 (20%)

Query: 39  ENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLS---C 95
           +++  A    P L +L++  N + D G+  ++    G      ++  L L+ C L+   C
Sbjct: 45  KDISSALRVNPALAELNLRSNELGDVGVHCVL---QGLQSPSCKIQKLSLQNCCLTGAGC 101

Query: 96  DVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGIDLLPSGFLE 155
            V++  L +LP    TL+ L +++N LG                    +G+ LL  G L+
Sbjct: 102 GVLSSTLRTLP----TLQELHLSDNLLGD-------------------AGLQLLCEGLLD 138

Query: 156 LQNMLTIEEELSLVIINISKNRGGIQTARFLSKLLPQAPRLVDVNASSNCMPIESLSIIS 215
            Q  L   E+L L   N+S       + + L+ +L   P   ++  S+N +    + ++ 
Sbjct: 139 PQCRL---EKLQLEYCNLS-----AASCKPLASVLRAKPDFKELTVSNNDINEAGVRVLC 190

Query: 216 SALK 219
             LK
Sbjct: 191 QGLK 194



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 26/73 (35%), Positives = 40/73 (54%), Gaps = 4/73 (5%)

Query: 51  LEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLPVLNG 110
           L +L IS+N +ED G++ L     G  +  S L  L L  CD+S    + L  +L + N 
Sbjct: 342 LLELQISNNRLEDAGVQELC---QGLGQPGSVLRVLWLADCDVSDSSCSSLAATL-LANH 397

Query: 111 TLKSLSIAENCLG 123
           +L+ L ++ NCLG
Sbjct: 398 SLRELDLSNNCLG 410


>RINI_HUMAN (P13489) Placental ribonuclease inhibitor
           (Ribonuclease/angiogenin inhibitor) (RAI) (RNase
           inhibitor) (RI)
          Length = 460

 Score = 38.9 bits (89), Expect = 0.012
 Identities = 42/162 (25%), Positives = 70/162 (42%), Gaps = 9/162 (5%)

Query: 32  NLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEAC 91
           +L     E L       P+ ++L +S+N I + G+R L     G  +   +L  LKLE+C
Sbjct: 152 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLC---QGLKDSPCQLEALKLESC 208

Query: 92  DLSCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGI---DL 148
            ++ D    L   +     +L+ L++  N LG      L   L  P   L    I    +
Sbjct: 209 GVTSDNCRDLC-GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 267

Query: 149 LPSGFLELQNMLTIEEELSLVIINISKNRGGIQTARFLSKLL 190
              G  +L  +L  +E  SL  ++++ N  G + AR L + L
Sbjct: 268 TAKGCGDLCRVLRAKE--SLKELSLAGNELGDEGARLLCETL 307



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 27/73 (36%), Positives = 40/73 (53%), Gaps = 4/73 (5%)

Query: 51  LEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLPVLNG 110
           L +L IS+N +ED G+R L     G  +  S L  L L  CD+S    + L  +L + N 
Sbjct: 342 LLELQISNNRLEDAGVRELC---QGLGQPGSVLRVLWLADCDVSDSSCSSLAATL-LANH 397

Query: 111 TLKSLSIAENCLG 123
           +L+ L ++ NCLG
Sbjct: 398 SLRELDLSNNCLG 410



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 25/76 (32%), Positives = 40/76 (51%), Gaps = 10/76 (13%)

Query: 48  MPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDL---SCDVVNHLLDS 104
           +P L++L +SDN + D GL+ L     G  +   RL  L+LE C L   SC+ +  +L +
Sbjct: 111 LPTLQELHLSDNLLGDAGLQLLC---EGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 167

Query: 105 LPVLNGTLKSLSIAEN 120
            P      K L+++ N
Sbjct: 168 KP----DFKELTVSNN 179


>NA12_HUMAN (P59046) NACHT-, LRR- and PYD-containing protein 12
           (PYRIN-containing APAF1-like protein 7) (Monarch-1)
          Length = 1061

 Score = 38.9 bits (89), Expect = 0.012
 Identities = 27/75 (36%), Positives = 40/75 (53%), Gaps = 4/75 (5%)

Query: 49  PNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLPVL 108
           P+L +LD++ N +ED GLR L     G      RL  L L+ C L+    + L  +L V 
Sbjct: 827 PHLVELDLTGNALEDLGLRLLC---QGLRHPVCRLRTLWLKICRLTAAACDELASTLSV- 882

Query: 109 NGTLKSLSIAENCLG 123
           N +L+ L ++ N LG
Sbjct: 883 NQSLRELDLSLNELG 897


>NAL5_MOUSE (Q9R1M5) NACHT-, LRR- and PYD-containing protein 5
           (Maternal antigen that embryos require) (Mater protein)
           (Ooplasm-specific protein 1) (OP1)
          Length = 1111

 Score = 38.1 bits (87), Expect = 0.020
 Identities = 37/136 (27%), Positives = 71/136 (52%), Gaps = 8/136 (5%)

Query: 50  NLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLPVLN 109
           NL+ L++ + P++D+ ++      A     CS +  L+L++C+L+  +   ++ +L +  
Sbjct: 749 NLKYLNLGNTPMKDDDMKLACE--ALKHPKCS-VETLRLDSCELTI-IGYEMISTLLIST 804

Query: 110 GTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGID---LLPSGFLELQNMLTIEEEL 166
             LK LS+A+N +G K   +LG  LS+ + +L    +D   L P+    L + L   + L
Sbjct: 805 TRLKCLSLAKNRVGVKSMISLGNALSSSMCLLQKLILDNCGLTPASCHLLVSALFSNQNL 864

Query: 167 S-LVIINISKNRGGIQ 181
           + L + N S    G+Q
Sbjct: 865 THLCLSNNSLGTEGVQ 880



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 29/117 (24%), Positives = 51/117 (42%), Gaps = 10/117 (8%)

Query: 33   LRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACD 92
            L ++  E+L        +L+ LD+ +N + D+G   +I    G  +  S L  L L AC 
Sbjct: 960  LTQNCCEDLACMITTTKHLKSLDLGNNALGDKG---VITLCEGLKQSSSSLRRLGLGACK 1016

Query: 93   LS---CDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGI 146
            L+   C+ ++  +   P LN    SL++ +N   +     L      P+  L   G+
Sbjct: 1017 LTSNCCEALSLAISCNPHLN----SLNLVKNDFSTSGMLKLCSAFQCPVSNLGIIGL 1069



 Score = 30.0 bits (66), Expect = 5.4
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 25/163 (15%)

Query: 76  TSEMCSRLACLKLEACDL---SCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGR 132
           +S MC  L  L L+ C L   SC    HLL S    N  L  L ++ N LG++    L +
Sbjct: 830 SSSMCL-LQKLILDNCGLTPASC----HLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQ 884

Query: 133 FLSTP---IEVLDASGIDLLPS--GFLELQNMLTIEEELSLVIINISKNRGGIQTARFLS 187
           FL  P   ++ L  +  +++    GFL ++    +     L  ++++ N  G    + L 
Sbjct: 885 FLRNPECALQRLILNHCNIVDDAYGFLAMR----LANNTKLTHLSLTMNPVGDGAMKLLC 940

Query: 188 KLLP------QAPRLVDVNASSNCMPIESLSIISSALKFAKGI 224
           + L       Q   LVD   + NC   E L+ + +  K  K +
Sbjct: 941 EALKEPTCYLQELELVDCQLTQNC--CEDLACMITTTKHLKSL 981


>NAL1_HUMAN (Q9C000) NACHT-, LRR- and PYD-containing protein 2
           (Death effector filament-forming ced-4-like apoptosis
           protein) (Nucleotide-binding domain and caspase
           recruitment domain) (Caspase recruitment domain protein
           7)
          Length = 1473

 Score = 38.1 bits (87), Expect = 0.020
 Identities = 38/153 (24%), Positives = 64/153 (40%), Gaps = 5/153 (3%)

Query: 30  GNNLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLE 89
           G  L  +D ++L +       L +LD+S N + D G ++L       S    +L  L+L 
Sbjct: 846 GCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS---CKLQRLQLV 902

Query: 90  ACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGIDLL 149
           +C L+ D    L   L   + +LK L + +N L       L   L  P   L   G+D  
Sbjct: 903 SCGLTSDCCQDLASVLSA-SPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQT 961

Query: 150 PSGFLELQNMLTIEEELSLVIINISKNRGGIQT 182
                  Q +  +E+E   ++I  S+ +  + T
Sbjct: 962 TLSDEMRQELRALEQEKPQLLI-FSRRKPSVMT 993


>NAL2_HUMAN (Q9NX02) NACHT-, LRR- and PYD-containing protein 2
           (PYRIN-containing APAF1-like protein 2)
           (Nucleotide-binding site protein 1)
          Length = 1062

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 9/154 (5%)

Query: 40  NLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVN 99
           +L  A     +L  +++SDN + DEG + L            RL+       + +C  + 
Sbjct: 802 DLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLA 861

Query: 100 HLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTP---IEVLDASGIDLLPSGFLEL 156
            +L    V++  L  L +A+N +G+     L   L  P   ++ L     D+   G  +L
Sbjct: 862 AVL----VVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDL 917

Query: 157 QNMLTIEEELSLVIINISKNRGGIQTARFLSKLL 190
             +L  +E+ SL+ +++  N  G++  +FL + L
Sbjct: 918 TKLL--QEKSSLLCLDLGLNHIGVKGMKFLCEAL 949


>NA14_HUMAN (Q86W24) NACHT-, LRR- and PYD-containing protein 14
            (Nucleotide-binding oligomerization domain protein 5)
          Length = 1093

 Score = 35.4 bits (80), Expect = 0.13
 Identities = 27/98 (27%), Positives = 46/98 (46%), Gaps = 4/98 (4%)

Query: 49   PNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLPVL 108
            PNL  LD+ +N ++D+G++ L       +    RL    LE C L+      L  +L + 
Sbjct: 957  PNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLG---LEYCGLTSLCCQDLSSAL-IC 1012

Query: 109  NGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGI 146
            N  L  +++ +N LG +    L + L +P   L   G+
Sbjct: 1013 NKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 38/159 (23%), Positives = 68/159 (41%), Gaps = 15/159 (9%)

Query: 38   AENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTS---EMCSRLACLKLEACDLS 94
            +E L  +  +  +L  LD+  N ++D G++ L   F   S   +    + C+   AC L 
Sbjct: 889  SEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLD 948

Query: 95   CDVVNHLLDSLPVLNGTLKSLSIAENCL---GSKVAGALGRFLSTPIEVLDASGIDLLPS 151
                   L S+ + N  L+SL +  N L   G K+     R+ +  I+ L      L   
Sbjct: 949  -------LASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001

Query: 152  GFLELQNMLTIEEELSLVIINISKNRGGIQTARFLSKLL 190
               +L + L   +   L+ +N+++N  G +    L K+L
Sbjct: 1002 CCQDLSSALICNKR--LIKMNLTQNTLGYEGIVKLYKVL 1038


>NAL5_HUMAN (P59047) NACHT-, LRR- and PYD-containing protein 5 (Mater
            protein homolog)
          Length = 1200

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 33/118 (27%), Positives = 47/118 (38%), Gaps = 6/118 (5%)

Query: 31   NNLRKDDAENLGYAFAYMPN--LEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKL 88
            N    D A     A A M N  L  L +S NP+ED G++ L       S     L  +K 
Sbjct: 988  NQCHLDTAGCGSLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKC 1047

Query: 89   EACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGI 146
                  C+ ++ ++      +  LKSL + +N LG     AL   L     VL   G+
Sbjct: 1048 HLTAACCESLSCVISR----SRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLTRLGL 1101



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 31/108 (28%), Positives = 48/108 (43%), Gaps = 4/108 (3%)

Query: 39   ENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVV 98
            E+L    +   +L+ LD++DN + D G+  L     G  +  S L  L L+AC L+ D  
Sbjct: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALC---EGLKQKNSVLTRLGLKACGLTSDCC 1111

Query: 99   NHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLDASGI 146
              L  +L   N  L SL++ +N    K    L    + P   L   G+
Sbjct: 1112 EALSLALS-CNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 26/89 (29%), Positives = 43/89 (48%), Gaps = 4/89 (4%)

Query: 49  PNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLPVL 108
           P+L+ L ++ N + D+G+  L    A     C+ L  L LE C ++      L  +L V 
Sbjct: 894 PSLKSLSLAGNKVTDQGVTPLSD--ALRVSQCA-LQKLILEDCGITATGCQSLASAL-VS 949

Query: 109 NGTLKSLSIAENCLGSKVAGALGRFLSTP 137
           N +L  L ++ N LG++    L R +  P
Sbjct: 950 NRSLTHLCLSNNSLGNEGVNLLCRSMRLP 978


>C2TA_MOUSE (P79621) MHC class II transactivator (CIITA)
          Length = 1155

 Score = 34.7 bits (78), Expect = 0.22
 Identities = 31/119 (26%), Positives = 55/119 (46%), Gaps = 6/119 (5%)

Query: 44   AFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLD 103
            AF+ + +L+   +S+N I D+G+  L    + T      L  L L   +++      L +
Sbjct: 1007 AFSSLQHLDLDSLSENKIGDKGVSKL----SATFPQLKALETLNLSQNNITDVGACKLAE 1062

Query: 104  SLPVLNGTLKSLSIAENCLGSKVAGALGRFL--STPIEVLDASGIDLLPSGFLELQNML 160
            +LP L  +L  LS+  NC+  K A +L + L     + V+D        +G  +L + L
Sbjct: 1063 ALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSL 1121


>RINI_RAT (P29315) Ribonuclease inhibitor
          Length = 456

 Score = 33.9 bits (76), Expect = 0.38
 Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 6/62 (9%)

Query: 48  MPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDL---SCDVVNHLLDS 104
           +  L +L ++DNP+ DEGL+ L     G  +   RL  L+LE C+L   SC+ +  +L  
Sbjct: 107 LSTLRELHLNDNPLGDEGLKLLC---EGLRDPQCRLEKLQLEYCNLTATSCEPLASVLRV 163

Query: 105 LP 106
            P
Sbjct: 164 KP 165



 Score = 33.1 bits (74), Expect = 0.64
 Identities = 36/141 (25%), Positives = 62/141 (43%), Gaps = 14/141 (9%)

Query: 49  PNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLS---CDVVNHLLDSL 105
           P L +L +  N + D G+  ++    G      ++  L L+ C L+   C V+  +L SL
Sbjct: 51  PALTELSLRTNELGDAGVGLVLQ---GLQNPTCKIQKLSLQNCSLTEAGCGVLPDVLRSL 107

Query: 106 PVLNGTLKSLSIAENCLGSKVAGALGRFLSTP---IEVLDASGIDLLPSGFLELQNMLTI 162
                TL+ L + +N LG +    L   L  P   +E L     +L  +    L ++L +
Sbjct: 108 ----STLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLRV 163

Query: 163 EEEL-SLVIINISKNRGGIQT 182
           + +   LV+ N   +  GI T
Sbjct: 164 KPDFKELVLSNNDFHEAGIHT 184


>CAR4_HUMAN (Q9Y239) Caspase recruitment domain protein 4 (Nod1
           protein)
          Length = 953

 Score = 33.9 bits (76), Expect = 0.38
 Identities = 41/192 (21%), Positives = 81/192 (41%), Gaps = 26/192 (13%)

Query: 37  DAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCD 96
           D   L +   + P    LD+ +N + D G+R L P F       SRL  L+L        
Sbjct: 691 DCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCF-------SRLTVLRLS------- 736

Query: 97  VVNHLLD-SLPVLNGTLKSLSIAE--NCLGSKVAGALGRFLSTPIEVLDASGIDLLPSGF 153
            VN + D  + VL+  L    I        +++     R+++  ++  +  G+  L  G 
Sbjct: 737 -VNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILD--ECKGLTHLKLGK 793

Query: 154 LELQN------MLTIEEELSLVIINISKNRGGIQTARFLSKLLPQAPRLVDVNASSNCMP 207
            ++ +       L ++   S+  + +  N+ G + A+  ++ L   P L  ++ +SN + 
Sbjct: 794 NKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGIS 853

Query: 208 IESLSIISSALK 219
            E    ++ AL+
Sbjct: 854 TEGGKSLARALQ 865



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 30/107 (28%), Positives = 48/107 (44%), Gaps = 5/107 (4%)

Query: 30  GNNLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLE 89
           GN +  + A+    A    P+L  L ++ N I  EG + L    A   +  + L  L L 
Sbjct: 821 GNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSL----ARALQQNTSLEILWLT 876

Query: 90  ACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLST 136
             +L+ +V   L + L V N TLK L + +N + +K    L   L +
Sbjct: 877 QNELNDEVAESLAEMLKV-NQTLKHLWLIQNQITAKGTAQLADALQS 922


>C2TA_HUMAN (P33076) MHC class II transactivator (CIITA)
          Length = 1130

 Score = 33.9 bits (76), Expect = 0.38
 Identities = 27/91 (29%), Positives = 44/91 (47%), Gaps = 4/91 (4%)

Query: 44   AFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLD 103
            AF+ + +L+   +S+N I DEG+  L    + T      L  L L   +++      L +
Sbjct: 982  AFSSLQHLDLDALSENKIGDEGVSQL----SATFPQLKSLETLNLSQNNITDLGAYKLAE 1037

Query: 104  SLPVLNGTLKSLSIAENCLGSKVAGALGRFL 134
            +LP L  +L  LS+  NC+    A +L R L
Sbjct: 1038 ALPSLAASLLRLSLYNNCICDVGAESLARVL 1068


>CIS1_MOUSE (Q8R4B8) Cold autoinflammatory syndrome 1 protein
           homolog (PYRIN-containing APAF1-like protein 1) (Mast
           cell maturation inducible protein 1)
          Length = 1033

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 10/90 (11%)

Query: 51  LEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLS---CDVVNHLLDSLPV 107
           L +LD+SDN + D G+R L     G   +   L  L L +C L+   C  +  +L S   
Sbjct: 797 LVELDLSDNALGDFGIRLLC---VGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSS--- 850

Query: 108 LNGTLKSLSIAENCLGSKVAGALGRFLSTP 137
            N +L  L I EN LG      L   +  P
Sbjct: 851 -NHSLTRLYIGENALGDSGVQVLCEKMKDP 879


>FXL3_MOUSE (Q8C4V4) F-box/LRR-repeat protein 3 (F-box/LRR-repeat
           protein 3A) (F-box and leucine-rich repeat protein 3A)
          Length = 428

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 26/93 (27%), Positives = 40/93 (42%), Gaps = 11/93 (11%)

Query: 30  GNNLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLE 89
           G ++ KD    +G      P L +L +  N     GLR L       +E C  L+ + L 
Sbjct: 316 GRSVSKDVLGRVGMT---CPRLVELVVCAN-----GLRPLDEELIRIAERCKNLSAIGLG 367

Query: 90  ACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCL 122
            C++SC      ++ + +  G L  LSI E  L
Sbjct: 368 ECEVSCSA---FVEFVKMCGGRLSQLSIMEEVL 397


>FXL3_HUMAN (Q9UKT7) F-box/LRR-repeat protein 3 (F-box/LRR-repeat
           protein 3A) (F-box and leucine-rich repeat protein 3A)
          Length = 428

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 26/93 (27%), Positives = 40/93 (42%), Gaps = 11/93 (11%)

Query: 30  GNNLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLE 89
           G ++ KD    +G      P L +L +  N     GLR L       +E C  L+ + L 
Sbjct: 316 GRSVSKDVLGRVGMT---CPRLVELVVCAN-----GLRPLDEELIRIAERCKNLSAIGLG 367

Query: 90  ACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCL 122
            C++SC      ++ + +  G L  LSI E  L
Sbjct: 368 ECEVSCSA---FVEFVKMCGGRLSQLSIMEEVL 397


>HMD1_ORYSA (P48019) 3-hydroxy-3-methylglutaryl-coenzyme A reductase
           (EC 1.1.1.34) (HMG-CoA reductase) (Fragment)
          Length = 509

 Score = 31.6 bits (70), Expect = 1.9
 Identities = 39/146 (26%), Positives = 66/146 (44%), Gaps = 24/146 (16%)

Query: 30  GNNLRKDDAEN-LGYAFAYMPNLEDLDISDNPIEDE---GLRYLIPYFAGTSEMCSRLAC 85
           G N+     EN LGY     P+++ + +S N   D+    + ++     G S +C  +  
Sbjct: 285 GMNMVSKGVENVLGYLQNVFPDMDVISVSGNYCSDKKPTAVNWIEG--RGKSVVCEAI-- 340

Query: 86  LKLEACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLD--- 142
                  +  DVV  +L +       L  L+I +N  GS VAGALG F +    ++    
Sbjct: 341 -------IKGDVVQKVLKTTVE---KLVELNIIKNLAGSAVAGALGGFNAHASNIVTALF 390

Query: 143 -ASGIDLLPSGFLELQNMLTIEEELS 167
            A+G D  P+  +E    +T+ EE++
Sbjct: 391 IATGQD--PAQNVESSQCITMLEEVN 414


>CYAA_NEUCR (Q01631) Adenylate cyclase (EC 4.6.1.1) (ATP
            pyrophosphate-lyase) (Adenylyl cyclase)
          Length = 2300

 Score = 31.6 bits (70), Expect = 1.9
 Identities = 37/147 (25%), Positives = 69/147 (46%), Gaps = 23/147 (15%)

Query: 17   ISREFLI*FLSHRGNNLRKDDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAGT 76
            + R+F+    + R      ++A+ L  +FA    L  LD+S+N ++D             
Sbjct: 907  VPRDFIQACTALRDIKYNNNEAQALPKSFATASKLTYLDVSNNRLQD----------LDH 956

Query: 77   SEMCSRLACLKLEACDLSCDVVNHLLDSLPVLNG---TLKSLSIAENCLGSKVAGALGRF 133
            SE+      LK+       ++ N+ L SLP   G   +L++L+I+ N L   V  +    
Sbjct: 957  SELSKLTGLLKV-------NLANNCLRSLPPTLGAYKSLRTLNISSNFL--DVFPSFICE 1007

Query: 134  LSTPIEV-LDASGIDLLPSGFLELQNM 159
            L T +++ L  + I+ LP   ++L+N+
Sbjct: 1008 LETIVDLDLSFNSINNLPDNLMKLRNL 1034


>CIS1_HUMAN (Q96P20) Cold autoinflammatory syndrome 1 protein
           (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3)
           (PYRIN-containing APAF1-like protein 1)
           (Angiotensin/vasopressin receptor AII/AVP-like)
          Length = 1034

 Score = 31.6 bits (70), Expect = 1.9
 Identities = 29/108 (26%), Positives = 45/108 (40%), Gaps = 14/108 (12%)

Query: 26  LSHRGNNLRK----------DDAENLGYAFAYMPNLEDLDISDNPIEDEGLRYLIPYFAG 75
           L H G N+R+          +   ++    +    L +LD+SDN + D G+R L     G
Sbjct: 763 LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC---VG 819

Query: 76  TSEMCSRLACLKLEACDLSCDVVNHLLDSLPVLNGTLKSLSIAENCLG 123
              +   L  L L +C L+      L   L   + +L  L + EN LG
Sbjct: 820 LKHLLCNLKKLWLVSCCLTSACCQDLASVLST-SHSLTRLYVGENALG 866


>HMD2_DICDI (P34136) 3-hydroxy-3-methylglutaryl-coenzyme A reductase
           2 (EC 1.1.1.34) (HMG-CoA reductase 2) (Fragment)
          Length = 481

 Score = 30.8 bits (68), Expect = 3.2
 Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 17/125 (13%)

Query: 47  YMPNLEDLDISDNPIEDEGLRYLIPYFAGTSEMCSRLACLKLEACDLSCDVVNHLLDSLP 106
           Y P +E L +S N   D+     I +  G  +     A +       S D+V    D L 
Sbjct: 263 YFPEMEVLSLSGNVCTDKKPSS-INWLEGRGKSVVAEAVI-------SGDIVR---DVLK 311

Query: 107 VLNGTLKSLSIAENCLGSKVAGALGRFLSTPIEVLD----ASGIDLLPSGFLELQNMLTI 162
                L SL+I +N +GS +AG++G F +    ++     A+G D  P+  +E  N +T+
Sbjct: 312 TTVEALVSLNIDKNLIGSAMAGSIGGFNAHASNIVTALYIATGQD--PAQNVESSNCITL 369

Query: 163 EEELS 167
            E ++
Sbjct: 370 MESIN 374


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.330    0.146    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,015,768
Number of Sequences: 164201
Number of extensions: 1136129
Number of successful extensions: 3526
Number of sequences better than 10.0: 35
Number of HSP's better than 10.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3485
Number of HSP's gapped (non-prelim): 74
length of query: 249
length of database: 59,974,054
effective HSP length: 108
effective length of query: 141
effective length of database: 42,240,346
effective search space: 5955888786
effective search space used: 5955888786
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 64 (29.3 bits)