BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146588.9 + phase: 0
(373 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24... 301 2e-81
MM13_HORSE (O18927) Collagenase 3 precursor (EC 3.4.24.-) (Matri... 139 1e-32
MM20_MOUSE (P57748) Matrix metalloproteinase-20 precursor (EC 3.... 137 4e-32
MM20_HUMAN (O60882) Matrix metalloproteinase-20 precursor (EC 3.... 135 1e-31
MM20_PIG (P79287) Matrix metalloproteinase-20 precursor (EC 3.4.... 135 2e-31
MM20_BOVIN (O18767) Matrix metalloproteinase-20 precursor (EC 3.... 135 2e-31
MM10_RAT (P07152) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix... 131 2e-30
MM10_MOUSE (O55123) Stromelysin-2 precursor (EC 3.4.24.22) (Matr... 129 9e-30
MM03_RABIT (P28863) Stromelysin-1 precursor (EC 3.4.24.17) (Matr... 129 9e-30
MM03_MOUSE (P28862) Stromelysin-1 precursor (EC 3.4.24.17) (Matr... 128 3e-29
MM28_HUMAN (Q9H239) Matrix metalloproteinase-28 precursor (EC 3.... 127 3e-29
MM13_RABIT (O62806) Collagenase 3 precursor (EC 3.4.24.-) (Matri... 127 6e-29
MM08_HUMAN (P22894) Neutrophil collagenase precursor (EC 3.4.24.... 125 2e-28
MM14_HUMAN (P50281) Matrix metalloproteinase-14 precursor (EC 3.... 121 2e-27
MM14_PIG (Q9XT90) Matrix metalloproteinase-14 precursor (EC 3.4.... 121 3e-27
MM14_MOUSE (P53690) Matrix metalloproteinase-14 precursor (EC 3.... 121 3e-27
MM08_RAT (O88766) Neutrophil collagenase precursor (EC 3.4.24.34... 120 4e-27
MM14_RABIT (Q95220) Matrix metalloproteinase-14 precursor (EC 3.... 118 2e-26
MM14_RAT (Q10739) Matrix metalloproteinase-14 precursor (EC 3.4.... 117 5e-26
MM17_MOUSE (Q9R0S3) Matrix metalloproteinase-17 precursor (EC 3.... 116 1e-25
>MEP1_SOYBN (P29136) Metalloendoproteinase 1 precursor (EC 3.4.24.-)
(SMEP1)
Length = 305
Score = 301 bits (770), Expect = 2e-81
Identities = 162/299 (54%), Positives = 194/299 (64%), Gaps = 21/299 (7%)
Query: 35 PGTLPVGP--WD--AFRNFTGCRQGENYNGLSNLKNYFQHFGYIPRSPKSNFSDDFDDDL 90
P GP WD A FT G+NY GLSN+KNYF H GYIP +P +F D+FDD L
Sbjct: 24 PSVSAHGPYAWDGEATYKFTTYHPGQNYKGLSNVKNYFHHLGYIPNAP--HFDDNFDDTL 81
Query: 91 QEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKL 150
AIKTYQKN+NLNVTG+ D TL+Q+M PRCGV DII T +TTS
Sbjct: 82 VSAIKTYQKNYNLNVTGKFDINTLKQIMTPRCGVPDIIINTN--------KTTS------ 127
Query: 151 RFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTETVKSVFATAFARWSEVTTLKFTET 210
F +S +T F PRW G +LTYAF P L +T KS A AF++W+ V + F ET
Sbjct: 128 -FGMISDYTFFKDMPRWQAGTTQLTYAFSPEPRLDDTFKSAIARAFSKWTPVVNIAFQET 186
Query: 211 TLYSGADIKIGFFNGDHGDGEPFDGSLGTLAHAFSPRNGRFHLDAAEDWVVSGDVSKSSL 270
T Y A+IKI F + +HGD PFDG G L HAF+P +GR H DA E WV SGDV+KS +
Sbjct: 187 TSYETANIKILFASKNHGDPYPFDGPGGILGHAFAPTDGRCHFDADEYWVASGDVTKSPV 246
Query: 271 PTAVDLESVAVHEIGHLLGLGHSSEEEAIMFPTISSRMKKVVLADDDVRGIQYLYGTNP 329
+A DLESVAVHEIGHLLGLGHSS+ AIM+P+I R +KV LA DD+ GI+ LYG NP
Sbjct: 247 TSAFDLESVAVHEIGHLLGLGHSSDLRAIMYPSIPPRTRKVNLAQDDIDGIRKLYGINP 305
>MM13_HORSE (O18927) Collagenase 3 precursor (EC 3.4.24.-) (Matrix
metalloproteinase-13) (MMP-13)
Length = 472
Score = 139 bits (350), Expect = 1e-32
Identities = 104/270 (38%), Positives = 127/270 (46%), Gaps = 52/270 (19%)
Query: 64 LKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCG 123
LK+Y Y P +P + + + ++ Q F L VTG+LDD TL + PRCG
Sbjct: 44 LKSY-----YYPLNPAGILKKTAANSVVDRLREMQSFFGLEVTGKLDDNTLDIMKKPRCG 98
Query: 124 VADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGN- 182
V D V + VFP +WP K LTY
Sbjct: 99 VPD----------------------------VGEYNVFPRTLKWP--KMNLTYRIVNYTP 128
Query: 183 ELTET-VKSVFATAFARWSEVTTLKFTETTLYSG-ADIKIGFFNGDHGDGEPFDGSLGTL 240
+LT + V+ F AF WS+VT L FT LY+G ADI I F +HGD PFDG G L
Sbjct: 129 DLTHSEVEKAFKKAFKVWSDVTPLNFTR--LYNGTADIMISFGTKEHGDFYPFDGPSGLL 186
Query: 241 AHAFSP---RNGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEEE 297
AHAF P G H D E W +S +L VA HE GH LGL HS +
Sbjct: 187 AHAFPPGPNYGGDAHFDDDETW--------TSSSKGYNLFLVAAHEFGHSLGLDHSKDPG 238
Query: 298 AIMFPTISSRMKK-VVLADDDVRGIQYLYG 326
A+MFP + K VL DDDV+GIQYLYG
Sbjct: 239 ALMFPIYTYTGKSHFVLPDDDVQGIQYLYG 268
>MM20_MOUSE (P57748) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 482
Score = 137 bits (345), Expect = 4e-32
Identities = 95/248 (38%), Positives = 117/248 (46%), Gaps = 49/248 (19%)
Query: 94 IKTYQKNFNLNVTGELDDMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKLRFH 153
IK Q F L VTG+LD T+ + PRCGV D+ N
Sbjct: 71 IKELQIFFGLKVTGKLDQNTMNVIKKPRCGVPDVAN------------------------ 106
Query: 154 TVSHFTVFPGQPRWPEGKQELTYA---FFPGNELTETVKSVFATAFARWSEVTTLKFTET 210
+ +FPG+P+W K LTY + P TE K++ A WS L F
Sbjct: 107 ----YRLFPGEPKWK--KNILTYRISKYTPSMSPTEVDKAI-QMALHAWSTAVPLNFVR- 158
Query: 211 TLYSG-ADIKIGFFNGDHGDGEPFDGSLGTLAHAFSP---RNGRFHLDAAEDWVVSGDVS 266
+ SG ADI I F GDHGD PFDG GTLAHAF+P G H D AE W +
Sbjct: 159 -INSGEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMG---- 213
Query: 267 KSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMFPTIS-SRMKKVVLADDDVRGIQYLY 325
+L +VA HE GH LGLGHS++ A+M+PT + L DDV+GIQ LY
Sbjct: 214 ----TNGFNLFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPYRFHLPKDDVKGIQALY 269
Query: 326 GTNPSFNG 333
G F G
Sbjct: 270 GPRKIFPG 277
>MM20_HUMAN (O60882) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 483
Score = 135 bits (341), Expect = 1e-31
Identities = 94/252 (37%), Positives = 116/252 (45%), Gaps = 49/252 (19%)
Query: 94 IKTYQKNFNLNVTGELDDMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKLRFH 153
IK Q F L VTG+LD T+ + PRCGV D+ N
Sbjct: 72 IKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVAN------------------------ 107
Query: 154 TVSHFTVFPGQPRWPEGKQELTYA---FFPGNELTETVKSVFATAFARWSEVTTLKFTET 210
+ +FPG+P+W K LTY + P E K+V A WS L F
Sbjct: 108 ----YRLFPGEPKWK--KNTLTYRISKYTPSMSSVEVDKAV-EMALQAWSSAVPLSFVR- 159
Query: 211 TLYSG-ADIKIGFFNGDHGDGEPFDGSLGTLAHAFSP---RNGRFHLDAAEDWVVSGDVS 266
+ SG ADI I F NGDHGD PFDG GTLAHAF+P G H D E W +
Sbjct: 160 -INSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNPEKWTMG---- 214
Query: 267 KSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMFPTISSRMK-KVVLADDDVRGIQYLY 325
+L +VA HE GH LGL HS++ A+M+PT + L DDV+GIQ LY
Sbjct: 215 ----TNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALY 270
Query: 326 GTNPSFNGSTVI 337
G F G +
Sbjct: 271 GPRKVFLGKPTL 282
>MM20_PIG (P79287) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 483
Score = 135 bits (340), Expect = 2e-31
Identities = 93/263 (35%), Positives = 116/263 (43%), Gaps = 46/263 (17%)
Query: 88 DDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSD 147
+ + + IK Q F L VTG+LD T+ + PRCGV D+ N
Sbjct: 66 NSMVKKIKELQAFFGLRVTGKLDRTTMDVIKRPRCGVPDVAN------------------ 107
Query: 148 SKLRFHTVSHFTVFPGQPRWPEGKQELTYAF--FPGNELTETVKSVFATAFARWSEVTTL 205
+ +FPG+P+W K LTY + + V A WS L
Sbjct: 108 ----------YRLFPGEPKWK--KNTLTYRISKYTPSMTPAEVDKAMEMALQAWSSAVPL 155
Query: 206 KFTETTLYSGADIKIGFFNGDHGDGEPFDGSLGTLAHAFSP---RNGRFHLDAAEDWVVS 262
F ADI I F GDHGD PFDG GTLAHAF+P G H D AE W +
Sbjct: 156 SFVRVNA-GEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMG 214
Query: 263 GDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMFPTIS-SRMKKVVLADDDVRGI 321
+L +VA HE GH LGL HS++ A+M+PT L DDV+GI
Sbjct: 215 --------MNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYQNPYGFHLPKDDVKGI 266
Query: 322 QYLYGTNPSFNGS-TVISSPERN 343
Q LYG +F G TV P N
Sbjct: 267 QALYGPRKTFTGKPTVPHGPPHN 289
>MM20_BOVIN (O18767) Matrix metalloproteinase-20 precursor (EC
3.4.24.-) (MMP-20) (Enamel metalloproteinase)
(Enamelysin)
Length = 481
Score = 135 bits (339), Expect = 2e-31
Identities = 93/257 (36%), Positives = 114/257 (44%), Gaps = 46/257 (17%)
Query: 94 IKTYQKNFNLNVTGELDDMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKLRFH 153
IK Q+ F L VTG+LD T+ + PRCGV D+ N
Sbjct: 70 IKELQEFFGLRVTGKLDRATMDVIKRPRCGVPDVAN------------------------ 105
Query: 154 TVSHFTVFPGQPRWPEGKQELTYAF--FPGNELTETVKSVFATAFARWSEVTTLKFTETT 211
+ +FPG+P+W K LTY + + V A WS L F
Sbjct: 106 ----YRLFPGEPKWK--KNTLTYRISKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRIN 159
Query: 212 LYSGADIKIGFFNGDHGDGEPFDGSLGTLAHAFSP---RNGRFHLDAAEDWVVSGDVSKS 268
ADI I F GDHGD PFDG GTLAHAF+P G H D AE W +
Sbjct: 160 A-GEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMG------ 212
Query: 269 SLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMFPTIS-SRMKKVVLADDDVRGIQYLYGT 327
+L +VA HE GH LGL HS++ A+MFPT L DDV+GIQ LYG
Sbjct: 213 --TNGFNLFTVAAHEFGHALGLAHSTDPSALMFPTYKYQNPYGFRLPKDDVKGIQALYGP 270
Query: 328 NPSFNGS-TVISSPERN 343
+F+G T P N
Sbjct: 271 RRAFSGKPTAPHGPPHN 287
>MM10_RAT (P07152) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix
metalloproteinase-10) (MMP-10) (Transin-2) (SL-2)
(Transformation-associated protein 34A)
Length = 476
Score = 131 bits (330), Expect = 2e-30
Identities = 89/290 (30%), Positives = 134/290 (45%), Gaps = 43/290 (14%)
Query: 56 ENYNGLSNLKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLR 115
++++ + + Y + + ++ K F + + I+ QK L +TG+LD T+
Sbjct: 26 QDHSTMDLAQQYLEKYYNFRKNEKQFFKRKDSSPVVKKIEEMQKFLGLEMTGKLDSNTVE 85
Query: 116 QVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELT 175
+ PRCGV D V F+ FPG P+W +
Sbjct: 86 MMHKPRCGVPD----------------------------VGGFSTFPGSPKWRKNHISYR 117
Query: 176 YAFFPGNELTETVKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDGEPFDG 235
+ + E+V S A W EVT L F+ + ADI I F G+HGD PFDG
Sbjct: 118 IVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRIS-EGEADIMISFAVGEHGDFYPFDG 176
Query: 236 SLGTLAHAFSPRNGRF---HLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGH 292
+LAHA+ P G + H D E W + P+ +L VA HE+GH LGL H
Sbjct: 177 VGQSLAHAYPPGPGFYGDAHFDDDEKWSLG--------PSGTNLFLVAAHELGHSLGLFH 228
Query: 293 SSEEEAIMFPT--ISSRMKKVVLADDDVRGIQYLYGTNPSFNGSTVISSP 340
S+ +E++M+P S+ + L+ DD+ GIQ LYG PS + +TV+ P
Sbjct: 229 SNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGARPS-SDATVVPVP 277
>MM10_MOUSE (O55123) Stromelysin-2 precursor (EC 3.4.24.22) (Matrix
metalloproteinase-10) (MMP-10) (Transin-2) (SL-2)
Length = 476
Score = 129 bits (325), Expect = 9e-30
Identities = 89/279 (31%), Positives = 129/279 (45%), Gaps = 46/279 (16%)
Query: 65 KNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGV 124
+ Y + + ++ K F + + I+ QK L +TG+LD T+ + PRCGV
Sbjct: 35 QQYLEKYYNFKKNEKQIFKRKDSSPVVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGV 94
Query: 125 ADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAF--FPGN 182
D V F+ FPG P+W K +TY + +
Sbjct: 95 PD----------------------------VGGFSTFPGSPKW--RKSHITYRIVNYTPD 124
Query: 183 ELTETVKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDGEPFDGSLGTLAH 242
++V S A W EVT L F+ + ADI I F G+HGD PFDG +LAH
Sbjct: 125 LPRQSVDSAIEKALKVWEEVTPLTFSRIS-EGEADIMISFAVGEHGDFYPFDGPGQSLAH 183
Query: 243 AFSPRNGRF---HLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAI 299
A+ P G + H D E W ++ P+ +L VA HE+GH LGL HS ++E++
Sbjct: 184 AYPPGPGFYGDVHFDDDEKWTLA--------PSGTNLFLVAAHELGHSLGLFHSDKKESL 235
Query: 300 MFPT--ISSRMKKVVLADDDVRGIQYLYGTNPSFNGSTV 336
M+P S+ L+ DD+ GIQ LYG PS + + V
Sbjct: 236 MYPVYRFSTSPANFHLSQDDIEGIQSLYGAGPSSDATVV 274
>MM03_RABIT (P28863) Stromelysin-1 precursor (EC 3.4.24.17) (Matrix
metalloproteinase-3) (MMP-3) (Transin-1) (SL-1)
Length = 478
Score = 129 bits (325), Expect = 9e-30
Identities = 94/288 (32%), Positives = 129/288 (44%), Gaps = 48/288 (16%)
Query: 51 GCRQGENYNGLSNLKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELD 110
G + + + L+ Y +++ + + K + + I+ QK L VTG+LD
Sbjct: 22 GASRDADTTNMDLLQQYLENYYNLEKDVKQFVKRKDSSPVVKKIQEMQKFLGLEVTGKLD 81
Query: 111 DMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEG 170
TL + PRCGV D V HF+ FPG P+W
Sbjct: 82 SNTLEVIRKPRCGVPD----------------------------VGHFSTFPGTPKWT-- 111
Query: 171 KQELTYAF--FPGNELTETVKSVFATAFARWSEVTTLKFTETTLYSG-ADIKIGFFNGDH 227
K LTY + + + V + A W EVT L F+ Y G ADI I F +H
Sbjct: 112 KTHLTYRIVNYTPDLPRDAVDAAIEKALKVWEEVTPLTFSRK--YEGEADIMISFGVREH 169
Query: 228 GDGEPFDGSLGTLAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEI 284
GD PFDG LAHA++P NG H D E W T +L VA HE+
Sbjct: 170 GDFIPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKD--------TTGTNLFLVAAHEL 221
Query: 285 GHLLGLGHSSEEEAIMFPTIS--SRMKKVVLADDDVRGIQYLYGTNPS 330
GH LGL HS+ EA+M+P + + + + L+ DDV GIQ LYG P+
Sbjct: 222 GHSLGLFHSANPEALMYPVYNAFTDLARFRLSQDDVDGIQSLYGPAPA 269
>MM03_MOUSE (P28862) Stromelysin-1 precursor (EC 3.4.24.17) (Matrix
metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2)
Length = 477
Score = 128 bits (321), Expect = 3e-29
Identities = 93/275 (33%), Positives = 130/275 (46%), Gaps = 46/275 (16%)
Query: 60 GLSNLKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVML 119
G+ L+ Y +++ + + K + + I+ QK L +TG+LD T+ +
Sbjct: 30 GMELLQKYLENYYGLAKDVKQFIKKKDSSLIVKKIQEMQKFLGLEMTGKLDSNTMELMHK 89
Query: 120 PRCGVADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAF- 178
PRCGV D V F+ FPG P+W K +TY
Sbjct: 90 PRCGVPD----------------------------VGGFSTFPGSPKW--RKSHITYRIV 119
Query: 179 -FPGNELTETVKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDGEPFDGSL 237
+ + ++V S A W EVT L F+ + ADI I F G+HGD PFDG
Sbjct: 120 NYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRIS-EGEADIMISFAVGEHGDFVPFDGPG 178
Query: 238 GTLAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSS 294
LAHA++P NG H D E W + DV T +L VA HE+GH LGL HS+
Sbjct: 179 TVLAHAYAPGPGINGDAHFDDDERW--TEDV------TGTNLFLVAAHELGHSLGLYHSA 230
Query: 295 EEEAIMFPTI--SSRMKKVVLADDDVRGIQYLYGT 327
+ EA+M+P S+ + + L+ DDV GIQ LYGT
Sbjct: 231 KAEALMYPVYKSSTDLSRFHLSQDDVDGIQSLYGT 265
>MM28_HUMAN (Q9H239) Matrix metalloproteinase-28 precursor (EC
3.4.24.-) (MMP-28) (Epilysin) (UNQ1893/PRO4339)
Length = 520
Score = 127 bits (320), Expect = 3e-29
Identities = 96/279 (34%), Positives = 129/279 (45%), Gaps = 26/279 (9%)
Query: 67 YFQHFGYIPRS-PKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVA 125
+ + +GY+ PK+ S F D AI+ +Q L V+G LD TLRQ+ PRCGV
Sbjct: 39 FLEKYGYLNEQVPKAPTSTRFSD----AIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVT 94
Query: 126 DIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAF--FPGNE 183
D T + A + + + + + F +W KQ L+Y +P +
Sbjct: 95 D----TNSYAAWAERISDLFARHRTKMRRKKRFAKQGN--KWY--KQHLSYRLVNWPEHL 146
Query: 184 LTETVKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDG--EPFDGSLGTLA 241
V+ AF WS V+ L+F E ADI++ FF GDH DG FDG G LA
Sbjct: 147 PEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALA 206
Query: 242 HAFSPRNGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMF 301
HAF PR G H D E W +S ++ L V HEIGH LGL HS A+M
Sbjct: 207 HAFLPRRGEAHFDQDERWSLSRRRGRN-------LFVVLAHEIGHTLGLTHSPAPRALMA 259
Query: 302 PTISSRMKKVVLADDDVRGIQYLYGTNPSFNGSTVISSP 340
P + +L+ DDV +Q LYG GS + P
Sbjct: 260 PYYKRLGRDALLSWDDVLAVQSLYG--KPLGGSVAVQLP 296
>MM13_RABIT (O62806) Collagenase 3 precursor (EC 3.4.24.-) (Matrix
metalloproteinase-13) (MMP-13)
Length = 471
Score = 127 bits (318), Expect = 6e-29
Identities = 90/259 (34%), Positives = 116/259 (44%), Gaps = 43/259 (16%)
Query: 73 YIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVADIINGTT 132
Y P +P + + + ++ Q F L VTG+LDD TL + PRCGV D
Sbjct: 47 YHPLNPAGILKKNAAGSMVDRLREMQSFFGLEVTGKLDDNTLAIMKQPRCGVPD------ 100
Query: 133 TMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTETVKSVF 192
V + VFP +W + + + V+ F
Sbjct: 101 ----------------------VGEYNVFPRTLKWSQTNLTYRIVNYTPDLTHSEVEKAF 138
Query: 193 ATAFARWSEVTTLKFTETTLYSG-ADIKIGFFNGDHGDGEPFDGSLGTLAHAFSP---RN 248
AF WS+VT L FT +++G ADI I F +HGD PFDG G LAHAF P
Sbjct: 139 KKAFKVWSDVTPLNFTR--IHNGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYG 196
Query: 249 GRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMFPTISSRM 308
G H D E W +S +L VA HE GH LGL HS + A+MFP +
Sbjct: 197 GDAHFDDDETW--------TSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTG 248
Query: 309 KK-VVLADDDVRGIQYLYG 326
K +L DDDV+GIQ LYG
Sbjct: 249 KSHFMLPDDDVQGIQSLYG 267
>MM08_HUMAN (P22894) Neutrophil collagenase precursor (EC 3.4.24.34)
(Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase)
(PMNL-CL)
Length = 467
Score = 125 bits (313), Expect = 2e-28
Identities = 93/286 (32%), Positives = 132/286 (45%), Gaps = 49/286 (17%)
Query: 64 LKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCG 123
+++Y + F +P + + + + + E +K Q+ F LNVTG+ ++ TL + PRCG
Sbjct: 33 VQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCG 92
Query: 124 VADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYA---FFP 180
V D F + PG P+W + LTY + P
Sbjct: 93 VPD----------------------------SGGFMLTPGNPKWE--RTNLTYRIRNYTP 122
Query: 181 GNELTET-VKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDGEPFDGSLGT 239
+L+E V+ AF WS + L FT + ADI I F+ DHGD PFDG G
Sbjct: 123 --QLSEAEVERAIKDAFELWSVASPLIFTRIS-QGEADINIAFYQRDHGDNSPFDGPNGI 179
Query: 240 LAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEE 296
LAHAF P G H DA E W ++ +L VA HE GH LGL HSS+
Sbjct: 180 LAHAFQPGQGIGGDAHFDAEETW--------TNTSANYNLFLVAAHEFGHSLGLAHSSDP 231
Query: 297 EAIMFPTISSR-MKKVVLADDDVRGIQYLYGTNPSFNGSTVISSPE 341
A+M+P + R L DD+ GIQ +YG + + T S+P+
Sbjct: 232 GALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPK 277
>MM14_HUMAN (P50281) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MMP-X1)
Length = 582
Score = 121 bits (304), Expect = 2e-27
Identities = 93/276 (33%), Positives = 118/276 (42%), Gaps = 35/276 (12%)
Query: 67 YFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVAD 126
+ Q +GY+P + L AI QK + L VTG+ D T++ + PRCGV D
Sbjct: 38 WLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPD 97
Query: 127 IINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTE 186
N + + H F + Q P+ + TY E
Sbjct: 98 KFGAEIKANVRRKRYAIQGLKWQ---HNEITFCI---QNYTPKVGEYATY---------E 142
Query: 187 TVKSVFATAFARWSEVTTLKFTETTL-------YSGADIKIGFFNGDHGDGEPFDGSLGT 239
++ AF W T L+F E ADI I F G HGD PFDG G
Sbjct: 143 AIRK----AFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGF 198
Query: 240 LAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEE 296
LAHA+ P G H D+AE W V + + D+ VAVHE+GH LGL HSS+
Sbjct: 199 LAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGN-----DIFLVAVHELGHALGLEHSSDP 253
Query: 297 EAIMFPTIS-SRMKKVVLADDDVRGIQYLYGTNPSF 331
AIM P + VL DDD RGIQ LYG F
Sbjct: 254 SAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGF 289
>MM14_PIG (Q9XT90) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP)
Length = 580
Score = 121 bits (303), Expect = 3e-27
Identities = 92/276 (33%), Positives = 119/276 (42%), Gaps = 35/276 (12%)
Query: 67 YFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVAD 126
+ Q +GY+P + L AI Q+ + L VTG+ D T++ + PRCGV D
Sbjct: 36 WLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLRVTGKADADTMKAMRRPRCGVPD 95
Query: 127 IINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTE 186
N + + H F + P+ E YA F E
Sbjct: 96 KFGAEIKANVRRKRYAIQGLKWQ---HNEITFCIQNYTPKVGE------YATF------E 140
Query: 187 TVKSVFATAFARWSEVTTLKFTETTL-------YSGADIKIGFFNGDHGDGEPFDGSLGT 239
++ AF W T L+F E ADI I F G HGD PFDG G
Sbjct: 141 AIRK----AFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGF 196
Query: 240 LAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEE 296
LAHA+ P G H D+AE W V + + D+ VAVHE+GH LGL HS++
Sbjct: 197 LAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGN-----DIFLVAVHELGHALGLEHSNDP 251
Query: 297 EAIMFPTIS-SRMKKVVLADDDVRGIQYLYGTNPSF 331
AIM P + VL DDD RGIQ LYG+ F
Sbjct: 252 SAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSESGF 287
>MM14_MOUSE (P53690) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MMP-X1) (MT-MMP)
Length = 582
Score = 121 bits (303), Expect = 3e-27
Identities = 97/288 (33%), Positives = 130/288 (44%), Gaps = 39/288 (13%)
Query: 51 GCRQGENYNGLSNLKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELD 110
G QG N++ + + Q +GY+P + L AI QK + L VTG+ D
Sbjct: 26 GWAQGSNFSP----EAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKAD 81
Query: 111 DMTLRQVMLPRCGVADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEG 170
T+ + PRCGV D T + A + + K + + ++ F + P+ E
Sbjct: 82 LATMMAMRRPRCGVPDKFG--TEIKANVRRKRYAIQGLKWQHNEIT-FCIQNYTPKVGE- 137
Query: 171 KQELTYAFFPGNELTETVKSVFATAFARWSEVTTLKFTETTL-------YSGADIKIGFF 223
YA F E ++ AF W T L+F E ADI I F
Sbjct: 138 -----YATF------EAIRK----AFRVWESATPLRFREVPYAYIREGHEKQADIMILFA 182
Query: 224 NGDHGDGEPFDGSLGTLAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVA 280
G HGD PFDG G LAHA+ P G H D+AE W V + + D+ VA
Sbjct: 183 EGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGN-----DIFLVA 237
Query: 281 VHEIGHLLGLGHSSEEEAIMFPTIS-SRMKKVVLADDDVRGIQYLYGT 327
VHE+GH LGL HS++ AIM P + VL DDD RGIQ LYG+
Sbjct: 238 VHELGHALGLEHSNDPSAIMSPFYQWMDTENFVLPDDDRRGIQQLYGS 285
>MM08_RAT (O88766) Neutrophil collagenase precursor (EC 3.4.24.34)
(Matrix metalloproteinase-8) (MMP-8)
Length = 466
Score = 120 bits (302), Expect = 4e-27
Identities = 96/279 (34%), Positives = 125/279 (44%), Gaps = 51/279 (18%)
Query: 61 LSNLKNYFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLP 120
+ +NY + F ++P + + + + E +K Q+ F L TG+ D T+ + P
Sbjct: 33 MKTAENYLRKFYHLPSNQFRSARNA--TMIAEKLKEMQRFFGLPETGKPDAATIEIMEKP 90
Query: 121 RCGVADIINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFF- 179
RCGV D F + PG P+W LTY
Sbjct: 91 RCGVPD----------------------------SGDFLLTPGSPKWTH--TNLTYRIIN 120
Query: 180 --PGNELTETVKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDGEPFDGSL 237
P E VK+ AF WS +TL FTE TL ADI I F + DHGD PFDG
Sbjct: 121 HTPQMSKAE-VKTEIEKAFKIWSVPSTLTFTE-TLEGEADINIAFVSRDHGDNSPFDGPN 178
Query: 238 GTLAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSS 294
G LAHAF P G H D+ E W SK+ +L VA HE GH LGL HS+
Sbjct: 179 GILAHAFQPGRGIGGDAHFDSEETWTQD---SKN-----YNLFLVAAHEFGHSLGLSHST 230
Query: 295 EEEAIMFPTISSRMKKVV-LADDDVRGIQYLYGTNPSFN 332
+ A+M+P + R L DD+ GIQ +YG PS N
Sbjct: 231 DPGALMYPNYAYREPSTYSLPQDDINGIQTIYG--PSDN 267
>MM14_RABIT (Q95220) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP)
Length = 582
Score = 118 bits (296), Expect = 2e-26
Identities = 90/272 (33%), Positives = 119/272 (43%), Gaps = 35/272 (12%)
Query: 67 YFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVAD 126
+ Q +GY+P + L AI Q+ + L VTG+ D T++ + PRCGV D
Sbjct: 38 WLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLRVTGKADTDTMKAMRRPRCGVPD 97
Query: 127 IINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTE 186
N + + H F + P+ E YA F E
Sbjct: 98 KFGAEIKANVRRKRYAIQGLKWQ---HNEITFCIQNYTPKVGE------YATF------E 142
Query: 187 TVKSVFATAFARWSEVTTLKFTETTL-------YSGADIKIGFFNGDHGDGEPFDGSLGT 239
++ AF W T L+F E ADI I F G HGD PFDG G
Sbjct: 143 AIRK----AFRVWESATPLRFREVHYAYIRDGREKQADIMIFFAEGFHGDSTPFDGEGGF 198
Query: 240 LAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEE 296
LAHA+ P G H D+AE W V + + D+ VAVHE+GH LGL HS++
Sbjct: 199 LAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGN-----DIFLVAVHELGHALGLEHSNDP 253
Query: 297 EAIMFPTIS-SRMKKVVLADDDVRGIQYLYGT 327
AIM P +K +L DD+ RGIQ LYG+
Sbjct: 254 SAIMAPFYQWMDTEKFLLPDDERRGIQQLYGS 285
>MM14_RAT (Q10739) Matrix metalloproteinase-14 precursor (EC
3.4.24.80) (MMP-14) (Membrane-type matrix
metalloproteinase 1) (MT-MMP 1) (MTMMP1)
(Membrane-type-1 matrix metalloproteinase) (MT1-MMP)
(MT1MMP) (MT-MMP)
Length = 582
Score = 117 bits (293), Expect = 5e-26
Identities = 91/272 (33%), Positives = 123/272 (44%), Gaps = 35/272 (12%)
Query: 67 YFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVAD 126
+ Q +GY+P + L AI Q+ + L VTG+ D T++ + PRCGV D
Sbjct: 38 WLQQYGYLPPGDLRTHTQRSPQSLSAAIAAIQRFYGLQVTGKADSDTMKAMRRPRCGVPD 97
Query: 127 IINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTE 186
T + A + + K + + ++ F + P+ E YA F E
Sbjct: 98 KFG--TEIKANVRRKRYAIQGLKWQHNEIT-FCIQNYTPKVGE------YATF------E 142
Query: 187 TVKSVFATAFARWSEVTTLKFTETTL-------YSGADIKIGFFNGDHGDGEPFDGSLGT 239
++ AF W T L+F E ADI I F G HGD PFDG G
Sbjct: 143 AIRK----AFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGF 198
Query: 240 LAHAFSPR---NGRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEE 296
LAHA+ P G H D+AE W V + + D+ VAVHE+GH LGL HS++
Sbjct: 199 LAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGN-----DIFLVAVHELGHALGLEHSNDP 253
Query: 297 EAIMFPTIS-SRMKKVVLADDDVRGIQYLYGT 327
IM P + VL DDD RGIQ LYG+
Sbjct: 254 SDIMAPFYQWMDTENFVLPDDDRRGIQQLYGS 285
>MM17_MOUSE (Q9R0S3) Matrix metalloproteinase-17 precursor (EC
3.4.24.-) (MMP-17) (Membrane-type matrix
metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix
metalloproteinase) (MT4-MMP)
Length = 578
Score = 116 bits (290), Expect = 1e-25
Identities = 87/283 (30%), Positives = 130/283 (45%), Gaps = 35/283 (12%)
Query: 67 YFQHFGYIPRSPKSNFSDDFDDDLQEAIKTYQKNFNLNVTGELDDMTLRQVMLPRCGVAD 126
+ FGY+P + ++ ++L +AI Q+ L TG LD+ TL + PRC + D
Sbjct: 54 WLSRFGYLPPADPASGQLQTQEELSKAITAMQQFGGLETTGILDEATLALMKTPRCSLPD 113
Query: 127 IINGTTTMNAGKDTETTSNSDSKLRFHTVSHFTVFPGQPRWPEGKQELTYAFFPGNELTE 186
+ G + + T S L + FP P G+ +
Sbjct: 114 LPPGAQSRRKRQTPPPTKWSKRNLSWRV----RTFPRDS--PLGR--------------D 153
Query: 187 TVKSVFATAFARWSEVTTLKFTETTLYSGADIKIGFFNGDHGDGEPFDGSLGTLAHAFSP 246
TV+++ A WS++T L F E + ADI+I F DH DG PFDG GT+AHAF P
Sbjct: 154 TVRALMYYALKVWSDITPLNFHEVA-GNAADIQIDFSKADHNDGYPFDGPGGTVAHAFFP 212
Query: 247 RN----GRFHLDAAEDWVVSGDVSKSSLPTAVDLESVAVHEIGHLLGLGHSSEEEAIMFP 302
+ G H D E W +SS +DL +VAVHE GH +GL H + +IM P
Sbjct: 213 GDHHTAGDTHFDDDEPWTF-----RSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQP 267
Query: 303 ----TISSRMKKVVLADDDVRGIQYLYGTNPSFNGSTVISSPE 341
+ ++ + +D VR + LYG S + + + +PE
Sbjct: 268 YYQGPVGDPLRYGLPYEDRVR-VWQLYGVRESVSPTAQLDTPE 309
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.319 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,787,003
Number of Sequences: 164201
Number of extensions: 2097121
Number of successful extensions: 5242
Number of sequences better than 10.0: 105
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 4852
Number of HSP's gapped (non-prelim): 180
length of query: 373
length of database: 59,974,054
effective HSP length: 112
effective length of query: 261
effective length of database: 41,583,542
effective search space: 10853304462
effective search space used: 10853304462
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Medicago: description of AC146588.9