BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146573.11 + phase: 2 /pseudo
(1025 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
RPB2_TRYBB (P17546) DNA-directed RNA polymerase II largest subun... 160 1e-38
RPB1_TRYBB (P17545) DNA-directed RNA polymerase II largest subun... 159 4e-38
RPB1_ASHGO (Q75A34) DNA-directed RNA polymerase II largest subun... 155 5e-37
RPA1_HALSA (P15350) DNA-directed RNA polymerase subunit A' (EC 2... 147 1e-34
RPA1_HALN1 (Q9HM79) DNA-directed RNA polymerase subunit A' (EC 2... 147 2e-34
RPB1_YEAST (P04050) DNA-directed RNA polymerase II largest subun... 145 5e-34
RPB1_SCHPO (P36594) DNA-directed RNA polymerase II largest subun... 141 1e-32
RPB1_DROME (P04052) DNA-directed RNA polymerase II largest subun... 141 1e-32
RPC1_SCHPO (O94666) DNA-directed RNA polymerase III largest subu... 140 1e-32
RPA1_SULAC (P11512) DNA-directed RNA polymerase subunit A' (EC 2... 140 2e-32
RPB1_MOUSE (P08775) DNA-directed RNA polymerase II largest subun... 139 5e-32
RPB1_HUMAN (P24928) DNA-directed RNA polymerase II largest subun... 139 5e-32
RPC1_YEAST (P04051) DNA-directed RNA polymerase III largest subu... 136 3e-31
RPB1_CAEEL (P16356) DNA-directed RNA polymerase II largest subun... 135 4e-31
RPC1_HUMAN (O14802) DNA-directed RNA polymerase III largest subu... 135 6e-31
RPB1_ARATH (P18616) DNA-directed RNA polymerase II largest subun... 135 6e-31
RPA1_THECE (P31813) DNA-directed RNA polymerase subunit A' (EC 2... 134 2e-30
RPA1_SULSO (Q980R2) DNA-directed RNA polymerase subunit A' (EC 2... 130 1e-29
RPC1_TRYBB (P08968) DNA-directed RNA polymerase III largest subu... 120 2e-26
RPA1_METTH (O27125) DNA-directed RNA polymerase subunit A' (EC 2... 119 3e-26
>RPB2_TRYBB (P17546) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6)
Length = 1766
Score = 160 bits (406), Expect = 1e-38
Identities = 140/553 (25%), Positives = 242/553 (43%), Gaps = 69/553 (12%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQINVRRNGNPVVLYKKED 331
+++ E+G+P +A L E VN N++ L + NG L D
Sbjct: 367 IDVDEVGVPFSVAMTLTFPERVNTVNKKRLTEFARRTVYPSANYIHHPNGTITKLALLRD 426
Query: 332 -----LQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPICCSPLR 386
L IGD+ R +++GD VL NR P++H+ SM+ VRVL S+ +N C +P
Sbjct: 427 RSKVTLNIGDVVERHVINGDVVLFNRQPTLHRMSMMGHRVRVLNYSTF-RLNLSCTTPYN 485
Query: 387 GDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHLLLEDGV 446
DFDGD ++ ++PQS+ + EL E++ + + ++ + + QDSL ++ L +
Sbjct: 486 ADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDT 545
Query: 447 GFNIYQVQQLEMLCNK-ELTSPAIFKAPSSNTPFWSGKQLFSMLLPSKFDYA-------F 498
+ Y VQ + + + +L PAI K P W+GKQ+FS++LP A F
Sbjct: 546 FLDKYFVQSVALWLDLWQLPIPAILKP----RPLWTGKQVFSLILPEVNHPATPQDRPPF 601
Query: 499 PSND--VFVKDGELISCSESSGWLRDSENNVFQSLV-EHFQGKILDVLHGAQKALCEWLS 555
P ND V ++ G+L+ + + + ++ + EH ++ ++G Q+ +L
Sbjct: 602 PHNDSVVMIRRGQLLCGPITKSIVGAAPGSLIHVIFNEHGSDEVARFINGVQRVTTFFLL 661
Query: 556 MTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLVDHYSDFLSASPEENE 615
GFSV + D SD+ + N +LV + N
Sbjct: 662 NFGFSVGVQDTVADSDTLRQ-------------------MNDVLVKTRRNVEKIGAAANN 702
Query: 616 KFVTVDVDRL---NHERQISAAQSQASVDAFRHVFRNIQSLADKHACKDNSFLAMFKAGS 672
+ + + E +++A ++ +A + N++ + NSF M +AGS
Sbjct: 703 RTLNRKAGMTLLQSFEADVNSALNKCREEAAKKALSNVR--------RTNSFKVMIEAGS 754
Query: 673 KGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSMEMSSDTLEPKQSYIA 732
KG L + Q ++ +G Q + AG G + L+ +
Sbjct: 755 KGTDLNICQIAVFVGQQ--------------NVAGSRIPFGFRRRTLPHFMLD-DYGETS 799
Query: 733 HAVVESSFLTGLNPLECFVHSVTNRDSSFSD--NADLPGTLTRRLMFFMRDMYDAYDGTV 790
+ ++ GL P E F H++ R+ G L R+L+ + D++ AYDGTV
Sbjct: 800 RGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTV 859
Query: 791 RNLYGNQLIQFSY 803
RN ++LIQF Y
Sbjct: 860 RNA-NDELIQFMY 871
>RPB1_TRYBB (P17545) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6)
Length = 1766
Score = 159 bits (402), Expect = 4e-38
Identities = 139/553 (25%), Positives = 242/553 (43%), Gaps = 69/553 (12%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQINVRRNGNPVVLYKKED 331
+++ E+G+P +A L E VN N++ L + NG L D
Sbjct: 367 IDVDEVGVPFSVAMTLTFPERVNTINKKRLTEFARRTVYPSANYIHHPNGTITKLALLRD 426
Query: 332 -----LQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPICCSPLR 386
L IGD+ R +++GD VL NR P++H+ SM+ VRVL ++ +N C +P
Sbjct: 427 RSKVTLNIGDVVERHVINGDVVLFNRQPTLHRMSMMGHRVRVLNYNTF-RLNLSCTTPYN 485
Query: 387 GDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHLLLEDGV 446
DFDGD ++ ++PQS+ + EL E++ + + ++ + + QDSL ++ L +
Sbjct: 486 ADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDT 545
Query: 447 GFNIYQVQQLEMLCNK-ELTSPAIFKAPSSNTPFWSGKQLFSMLLPSKFDYA-------F 498
+ Y VQ + + + +L PAI K P W+GKQ+FS++LP A F
Sbjct: 546 FLDKYFVQSVALWLDLWQLPIPAILKP----RPLWTGKQVFSLILPEVNHPATPQDRPPF 601
Query: 499 PSND--VFVKDGELISCSESSGWLRDSENNVFQSLV-EHFQGKILDVLHGAQKALCEWLS 555
P ND V ++ G+L+ + + + ++ + EH ++ ++G Q+ +L
Sbjct: 602 PHNDSVVMIRRGQLLCGPITKSIVGAAPGSLIHVIFNEHGSDEVARFINGVQRVTTFFLL 661
Query: 556 MTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLVDHYSDFLSASPEENE 615
GFSV + D SD+ + N +LV + N
Sbjct: 662 NFGFSVGVQDTVADSDTLRQ-------------------MNDVLVKTRRNVEKIGAAANN 702
Query: 616 KFVTVDVDRL---NHERQISAAQSQASVDAFRHVFRNIQSLADKHACKDNSFLAMFKAGS 672
+ + + E +++A ++ +A + N++ + NSF M +AGS
Sbjct: 703 RTLNRKAGMTLLQSFEADVNSALNKCREEAAKKALSNVR--------RTNSFKVMIEAGS 754
Query: 673 KGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSMEMSSDTLEPKQSYIA 732
KG L + Q ++ +G Q + AG G + L+ +
Sbjct: 755 KGTDLNICQIAVFVGQQ--------------NVAGSRIPFGFRRRTLPHFMLD-DYGETS 799
Query: 733 HAVVESSFLTGLNPLECFVHSVTNRDSSFSD--NADLPGTLTRRLMFFMRDMYDAYDGTV 790
+ ++ GL P E F H++ R+ G L R+L+ + D++ AYDGTV
Sbjct: 800 RGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTV 859
Query: 791 RNLYGNQLIQFSY 803
RN ++LIQF Y
Sbjct: 860 RNA-NDELIQFMY 871
>RPB1_ASHGO (Q75A34) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6) (RNA polymerase II subunit 1)
Length = 1745
Score = 155 bits (392), Expect = 5e-37
Identities = 159/564 (28%), Positives = 250/564 (44%), Gaps = 86/564 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKG-------QINVRRNGNPV 324
L+L ++G+P IA+ L E V N L +L+ G + +R NG+ +
Sbjct: 359 LDLDQVGVPKSIAKTLTYPEVVTPYNIDRLT-----QLVRNGPNEHPGAKYVIRDNGDRI 413
Query: 325 VL-YKKE----DLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINP 379
L Y K LQ G R ++D D VL NR PS+H+ SM+A V+V+P S+ +N
Sbjct: 414 DLRYSKRAGDIQLQYGWKVERHIMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTF-RLNL 472
Query: 380 ICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAH 439
SP DFDGD ++ ++PQS R EL++L A+ Q+++ QS + + QD+L
Sbjct: 473 SVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIR 532
Query: 440 LLLEDGVGFNIYQVQQLEMLC-----NKELTSPAIFKAPSSNTPFWSGKQLFSMLLPS-- 492
+ + QV L ML + + +P I K P WSGKQL SM +PS
Sbjct: 533 KMTLRDTFIELDQV--LNMLYWIPDWDGVIPTPTILKPK----PLWSGKQLLSMAIPSGI 586
Query: 493 ---KFD----YAFPS-NDVFVKDGELISCSESSGWLRDSENNVFQSLVEHFQGKILDVLH 544
+FD Y P N + + DG++I + S + + ++ L
Sbjct: 587 HLQRFDEGTTYLSPKDNGMLIIDGQIIFGVVDKKTVGSSSGGLIHVVTREKGPEVCAKLF 646
Query: 545 G-AQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLVDHY 603
G QK + WL GFS+ + D + A + M EI+ + +A++ + ++ +
Sbjct: 647 GNIQKVVNYWLLHNGFSIGIGD------TIADEKTMREITDAIALAKKKVE--EVTKEAQ 698
Query: 604 SDFLSASPEEN--EKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLADKHACKD 661
++ L+A E F V LN R + ++ N++ L
Sbjct: 699 ANLLTAKHGMTLRESFEDNVVRYLNEARDKAGRSAEV----------NLKDL-------- 740
Query: 662 NSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSMEMSS 721
N+ M AGSKG+ + + Q S C+G Q + + G+ + H S
Sbjct: 741 NNVKQMVSAGSKGSFINIAQMSACVGQQS--------VEGKRIAFGFADRTLPH---FSK 789
Query: 722 DTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADLP--GTLTRRLMFFM 779
D P+ VE+S+L GL P E F H++ R+ G + RRL+ +
Sbjct: 790 DDYSPESK----GFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKAL 845
Query: 780 RDMYDAYDGTVRNLYGNQLIQFSY 803
D+ YDGT RN GN +IQF Y
Sbjct: 846 EDIMVHYDGTTRNSLGN-IIQFVY 868
Score = 40.4 bits (93), Expect = 0.025
Identities = 21/73 (28%), Positives = 38/73 (51%), Gaps = 10/73 (13%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPAC------ 99
LG + ++ C TCG + C GHFG I+ + H F+++I ++ + +C C
Sbjct: 58 LGSIDRNFKCQTCG-EGMNDCPGHFGHIELAKPVFHIGFISKIKKVCECVCMHCGKLLLD 116
Query: 100 ---KSIRQEIRVK 109
+ +RQ I++K
Sbjct: 117 EYNELMRQAIKIK 129
>RPA1_HALSA (P15350) DNA-directed RNA polymerase subunit A' (EC
2.7.7.6)
Length = 971
Score = 147 bits (371), Expect = 1e-34
Identities = 149/580 (25%), Positives = 258/580 (43%), Gaps = 92/580 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQIN-------VRRNGNPV 324
L L+E+G+P ++A + + VN QN + R + G R +G V
Sbjct: 404 LSLNEVGVPDRVATEMTQTMVVNEQNLERAR-----RYVRNGPEGHPGANYVTRPDGRRV 458
Query: 325 VLYKK------EDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSIN 378
+ +K E ++ G R L+DGD ++ NR PS+H+ S++A V V+P + +N
Sbjct: 459 RVTEKVCEELAERVEPGWEVQRHLIDGDIIIFNRQPSLHRMSIMAHEVVVMPYKTF-RLN 517
Query: 379 PICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAA 438
+ C P DFDGD ++ + Q+ AR E L+ + Q+++ + G N++ QD ++
Sbjct: 518 TVVCPPYNADFDGDEMNMHALQNEEARAEARVLMRVQEQILSPRFGENIIGAIQDHISGT 577
Query: 439 HLLLEDGVGFNIYQVQQLEMLCNKELTS-PAIFKAPSSNTPFWSGKQLFSMLLPSKFDYA 497
+LL D FN + Q ++L + PA +W+G Q+FS LLP
Sbjct: 578 YLLTNDNPRFN--ETQASDLLRQTRIDELPAAAGTDEDGDQYWTGHQIFSELLPDDLSLE 635
Query: 498 F---PSNDVFVKDGELISCSESSGWLRDSENNVFQSLVEHFQGKILDVL---HGAQKA-- 549
F + V ++DG+L+ G + D E V + +I+D + HG +A
Sbjct: 636 FTGTTGDTVVIEDGQLL-----EGTIADDE-------VGEYGSEIVDTITKVHGNTRARI 683
Query: 550 -LCEWLSMT-------GFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLVD 601
+ E S+ GFS+ + D +S++ AR+ + E I + A D Q L++
Sbjct: 684 FINEVASLAMRSIMHFGFSIGIDDETVSTE--ARERIDEAI-------QSAIDRVQELIE 734
Query: 602 HYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLADKHACKD 661
Y + E+ TVD E +I +A A +A+++ +D
Sbjct: 735 TYEN----GDLESLPGRTVDE---TLEMKIMQTLGKARDSA--------GDVAEENFDED 779
Query: 662 NSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSMEMSS 721
N + M +G++G++L L Q + C+G Q + G +G +S
Sbjct: 780 NPAVVMANSGARGSMLNLTQMAGCVGQQ--------------AVRGERINRGYEDRTLSH 825
Query: 722 DTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDS--SFSDNADLPGTLTRRLMFFM 779
S AH VE+S+ +GL P E F H++ R+ + G L RRL+ +
Sbjct: 826 FAPNDLSSE-AHGFVENSYTSGLTPKEFFFHAMGGREGLVDTAVRTSKSGYLQRRLINAL 884
Query: 780 RDMYDAYDGTVRNLYGNQLIQFSYDAEEDSSCDSYFREDI 819
++ YDGTVR+ + ++QF + + S E++
Sbjct: 885 SELETQYDGTVRDT-SDTIVQFEFGEDGTSPVQVSSNEEV 923
Score = 39.7 bits (91), Expect = 0.042
Identities = 19/57 (33%), Positives = 28/57 (48%), Gaps = 1/57 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
LG+ + C TCG + C GHFG I+ ++H F I +L+ C C S+
Sbjct: 53 LGVIDPGLECKTCGQRSG-GCNGHFGHIELAAPVIHVGFSKLIRRLLRGTCRECASL 108
>RPA1_HALN1 (Q9HM79) DNA-directed RNA polymerase subunit A' (EC
2.7.7.6)
Length = 971
Score = 147 bits (370), Expect = 2e-34
Identities = 149/580 (25%), Positives = 258/580 (43%), Gaps = 92/580 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQIN-------VRRNGNPV 324
L L+E+G+P ++A + + VN QN + R + G R +G V
Sbjct: 404 LSLNEVGVPDRVATEMTQTMVVNEQNLERAR-----RYVRNGPEGHPGANYVTRPDGRRV 458
Query: 325 VLYKK------EDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSIN 378
+ +K E ++ G R L+DGD ++ NR PS+H+ S++A V V+P + +N
Sbjct: 459 RVTEKVCEELAERVEPGWEVQRHLIDGDIIIFNRQPSLHRMSIMAHEVVVMPYKTF-RLN 517
Query: 379 PICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAA 438
+ C P DFDGD ++ + Q+ AR E L+ + Q+++ + G N++ QD ++
Sbjct: 518 TVVCPPYNADFDGDEMNMHALQNEEARAEARVLMRVQEQILSPRFGENIIGAIQDHISGT 577
Query: 439 HLLLEDGVGFNIYQVQQLEMLCNKELTS-PAIFKAPSSNTPFWSGKQLFSMLLPSKFDYA 497
+LL D FN + Q ++L + PA +W+G Q+FS LLP
Sbjct: 578 YLLTNDNPRFN--ETQASDLLRQTRIDELPAAAGTDEDGDQYWTGHQIFSELLPDDLSLE 635
Query: 498 F---PSNDVFVKDGELISCSESSGWLRDSENNVFQSLVEHFQGKILDVL---HGAQKA-- 549
F + V ++DG+L+ G + D E V + +I+D + HG +A
Sbjct: 636 FTGTTGDTVVIEDGQLL-----EGTIADDE-------VGEYGSEIVDTITKVHGNTRARI 683
Query: 550 -LCEWLSMT-------GFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLVD 601
+ E S+ GFS+ + D +S++ AR+ + E I + A D Q L++
Sbjct: 684 FINEVASLAMRSIMHFGFSIGIDDETVSTE--ARERIDEAI-------QSAYDRVQELIE 734
Query: 602 HYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLADKHACKD 661
Y + E+ TVD E +I +A A +A+++ +D
Sbjct: 735 TYEN----GDLESLPGRTVDE---TLEMKIMQTLGKARDSA--------GDVAEENFDED 779
Query: 662 NSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSMEMSS 721
N + M +G++G++L L Q + C+G Q + G +G +S
Sbjct: 780 NPAVVMANSGARGSMLNLTQMAGCVGQQ--------------AVRGERINRGYEDRTLSH 825
Query: 722 DTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDS--SFSDNADLPGTLTRRLMFFM 779
S AH VE+S+ +GL P E F H++ R+ + G L RRL+ +
Sbjct: 826 FAPNDLSSE-AHGFVENSYTSGLTPKEFFFHAMGGREGLVDTAVRTSKSGYLQRRLINAL 884
Query: 780 RDMYDAYDGTVRNLYGNQLIQFSYDAEEDSSCDSYFREDI 819
++ YDGTVR+ + ++QF + + S E++
Sbjct: 885 SELETQYDGTVRDT-SDTIVQFEFGEDGTSPVQVSSNEEV 923
Score = 39.7 bits (91), Expect = 0.042
Identities = 19/57 (33%), Positives = 28/57 (48%), Gaps = 1/57 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
LG+ + C TCG + C GHFG I+ ++H F I +L+ C C S+
Sbjct: 53 LGVIDPGLECKTCGQRSG-GCNGHFGHIELAAPVIHVGFSKLIRRLLRGTCRECASL 108
>RPB1_YEAST (P04050) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6) (RNA polymerase II subunit 1) (B220)
Length = 1733
Score = 145 bits (366), Expect = 5e-34
Identities = 171/654 (26%), Positives = 274/654 (41%), Gaps = 125/654 (19%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKG-------QINVRRNGNPV 324
LEL ++G+P IA+ L E V N L +L+ G + +R +G+ +
Sbjct: 359 LELDQVGVPKSIAKTLTYPEVVTPYNIDRLT-----QLVRNGPNEHPGAKYVIRDSGDRI 413
Query: 325 VL-YKKE----DLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINP 379
L Y K LQ G R ++D D VL NR PS+H+ SM+A V+V+P S+ +N
Sbjct: 414 DLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTF-RLNL 472
Query: 380 ICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAH 439
SP DFDGD ++ ++PQS R EL++L A+ Q+++ QS + + QD+L
Sbjct: 473 SVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIR 532
Query: 440 LLLEDGVGFNIYQVQQLEMLC-----NKELTSPAIFKAPSSNTPFWSGKQLFSMLLPS-- 492
L + QV L ML + + +PAI K P WSGKQ+ S+ +P+
Sbjct: 533 KLTLRDTFIELDQV--LNMLYWVPDWDGVIPTPAIIKPK----PLWSGKQILSVAIPNGI 586
Query: 493 ---KFDYAFP-----SNDVFVKDGELISCSESSGWLRDSENNVFQSLVEHFQGKILDVLH 544
+FD N + + DG++I + S + + ++ L
Sbjct: 587 HLQRFDEGTTLLSPKDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLF 646
Query: 545 G-AQKALCEWLSMTGFSVSLSDLYLSSDSY---------ARKNMME---EISYGLRVAEQ 591
G QK + WL GFS + D + A+K +++ E L A+
Sbjct: 647 GNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKH 706
Query: 592 ACDFNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQ 651
+ D+ FL+ + ++ + V++ LN+ +Q
Sbjct: 707 GMTLRESFEDNVVRFLNEARDKAGRLAEVNLKDLNNVKQ--------------------- 745
Query: 652 SLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQ 711
M AGSKG+ + + Q S C+G Q + + G+ +
Sbjct: 746 ---------------MVMAGSKGSFINIAQMSACVGQQ--------SVEGKRIAFGFVDR 782
Query: 712 KGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--PG 769
H S D P+ + VE+S+L GL P E F H++ R+ G
Sbjct: 783 TLPH---FSKDDYSPE----SKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETG 835
Query: 770 TLTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSYDAEEDSSCDSYFRE---DIIGGEPVG 826
+ RRL+ + D+ YD T RN GN +IQF Y ED ++ + D IGG
Sbjct: 836 YIQRRLVKALEDIMVHYDNTTRNSLGN-VIQFIYG--EDGMDAAHIEKQSLDTIGG---- 888
Query: 827 ALSACAVSEAAYSALSQPISLLEASPLLNLKNVLECGSRKKGGDQTVSLFLSEK 880
S+AA+ + + LL L+ ++LE GS GD + + L E+
Sbjct: 889 -------SDAAFEKRYR-VDLLNTDHTLD-PSLLESGSEIL-GDLKLQVLLDEE 932
Score = 36.2 bits (82), Expect = 0.46
Identities = 17/54 (31%), Positives = 27/54 (49%), Gaps = 1/54 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPAC 99
LG + + C TC + C GHFG I + H F+A+I ++ + +C C
Sbjct: 58 LGSIDRNLKCQTC-QEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHC 110
>RPB1_SCHPO (P36594) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6) (RNA polymerase II subunit 1)
Length = 1752
Score = 141 bits (355), Expect = 1e-32
Identities = 147/560 (26%), Positives = 252/560 (44%), Gaps = 78/560 (13%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKG-------QINVRRNGNPV 324
L L E+G+P IA+ L E V N L L+ G + +R G +
Sbjct: 365 LSLDELGVPRSIAKTLTYPETVTPYNIYQLQ-----ELVRNGPDEHPGAKYIIRDTGERI 419
Query: 325 VL-YKKE----DLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINP 379
L Y K L+ G R + DGD V+ NR PS+H+ SM+ +RV+P S+ +N
Sbjct: 420 DLRYHKRAGDIPLRYGWRVERHIRDGDVVIFNRQPSLHKMSMMGHRIRVMPYSTF-RLNL 478
Query: 380 ICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAH 439
SP DFDGD ++ ++PQS R E+ E+ + +Q+++ QS ++ + QD+L
Sbjct: 479 SVTSPYNADFDGDEMNMHVPQSEETRAEIQEITMVPKQIVSPQSNKPVMGIVQDTLAGVR 538
Query: 440 --LLLEDGVGFNIYQVQQLEMLCNKELTSPAIFKAPSSNTPFWSGKQLFSMLLP------ 491
L ++ + N L + + P + P W+GKQ+ S+++P
Sbjct: 539 KFSLRDNFLTRNAVMNIMLWVPDWDGILPPPVILKPK---VLWTGKQILSLIIPKGINLI 595
Query: 492 ---SKFDYAFPSND-VFVKDGELISCSESSGWLRDSENNVFQSLVEHFQGKIL-DVLHGA 546
K + P++ + +++GE+I + S+ + ++ + +I +G
Sbjct: 596 RDDDKQSLSNPTDSGMLIENGEIIYGVVDKKTVGASQGGLVHTIWKEKGPEICKGFFNGI 655
Query: 547 QKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLVDHYSDF 606
Q+ + WL GFS+ + D +D+ M+E++ ++ A + + + D +
Sbjct: 656 QRVVNYWLLHNGFSIGIGDTIADADT------MKEVTRTVKEARR--QVAECIQDAQHNR 707
Query: 607 LSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLADKHACKD-NSFL 665
L P +T+ R + E ++S +QA +A R + +H+ KD N+
Sbjct: 708 LKPEPG-----MTL---RESFEAKVSRILNQARDNAGR---------SAEHSLKDSNNVK 750
Query: 666 AMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSMEMSSDTLE 725
M AGSKG+ + + Q S C+G Q + RIP + L D+ E
Sbjct: 751 QMVAAGSKGSFINISQMSACVGQQ---IVEGKRIPFGF------KYRTLPHFPKDDDSPE 801
Query: 726 PKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--PGTLTRRLMFFMRDMY 783
+ +E+S+L GL P E F H++ R+ G + RRL+ M D+
Sbjct: 802 ------SRGFIENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKAMEDVM 855
Query: 784 DAYDGTVRNLYGNQLIQFSY 803
YDGTVRN G+ +IQF+Y
Sbjct: 856 VRYDGTVRNAMGD-IIQFAY 874
Score = 41.6 bits (96), Expect = 0.011
Identities = 19/58 (32%), Positives = 32/58 (54%), Gaps = 1/58 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSIR 103
LG + + C TCG + C GHFG I+ + H F+++I +IL+ +C C ++
Sbjct: 60 LGTIDRQFKCQTCG-ETMADCPGHFGHIELAKPVFHIGFLSKIKKILECVCWNCGKLK 116
>RPB1_DROME (P04052) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6)
Length = 1887
Score = 141 bits (355), Expect = 1e-32
Identities = 157/582 (26%), Positives = 246/582 (41%), Gaps = 99/582 (17%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQIN-------VRRNGNPV 324
L + ++G+P IA+ L E V N + L+ +G VR NG +
Sbjct: 365 LRIDQVGVPRSIAQNLTFPELVTPFNIDRMQ-----ELVRRGNSQYPGAKYIVRDNGERI 419
Query: 325 VLY---KKEDL--QIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINP 379
L K DL Q G R L D D V+ NR P++H+ SM+ V+VLP S+ +N
Sbjct: 420 DLRFHPKSSDLHLQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPWSTF-RMNL 478
Query: 380 ICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAH 439
C SP DFDGD ++ ++PQS+ R E+ + RQ+I Q+ ++ + QD+LTA
Sbjct: 479 SCTSPYNADFDGDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVR 538
Query: 440 LLLEDGVGFNIYQVQQLEMLC---NKELTSPAIFKAPSSNTPFWSGKQLFSMLLPSK--- 493
+ + V QV L M + ++ P I K P W+GKQ+FS+++P
Sbjct: 539 KMTKRDVFITREQVMNLLMFLPTWDAKMPQPCILKP----RPLWTGKQIFSLIIPGNVNM 594
Query: 494 ---------------FDYAFPSN-DVFVKDGELIS---CSESSGWLRDSENNV-FQSLVE 533
+ + P + V V+ GELI C +S G S ++ F L
Sbjct: 595 IRTHSTHPDEEDEGPYKWISPGDTKVMVEHGELIMGILCKKSLGTSAGSLLHICFLELGH 654
Query: 534 HFQGKILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQAC 593
G+ Q + WL G S+ + D +Y EI ++ A+
Sbjct: 655 DIAGRFYG---NIQTVINNWLLFEGHSIGIGDTIADPQTY------NEIQQAIKKAKD-- 703
Query: 594 DFNQLLVDHYSDFLSASPEE--NEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQ 651
D ++ ++ L +P + F LN R + ++ S+ +
Sbjct: 704 DVINVIQKAHNMELEPTPGNTLRQTFENKVNRILNDARDKTGGSAKKSLTEY-------- 755
Query: 652 SLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQ 711
N+ AM +GSKG+ + + Q C+G Q+ + RIP G+ +
Sbjct: 756 ----------NNLKAMVVSGSKGSNINISQVIACVGQQNVEGK---RIP-----YGFRKR 797
Query: 712 KGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--PG 769
H ++ D P+ + VE+S+L GL P E + H++ R+ G
Sbjct: 798 TLPHFIK---DDYGPE----SRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETG 850
Query: 770 TLTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSYDAEEDSSC 811
+ RRL+ M + YDGTVRN G QLIQ Y ED C
Sbjct: 851 YIQRRLIKAMESVMVNYDGTVRNSVG-QLIQLRYG--EDGLC 889
Score = 33.1 bits (74), Expect = 3.9
Identities = 16/56 (28%), Positives = 27/56 (47%), Gaps = 1/56 (1%)
Query: 47 GLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
G+ + + C TC + C GHFG I + H F+ + +IL+ +C C +
Sbjct: 59 GVIDRTSRCQTCAG-NMTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKM 113
>RPC1_SCHPO (O94666) DNA-directed RNA polymerase III largest subunit
(EC 2.7.7.6)
Length = 1405
Score = 140 bits (354), Expect = 1e-32
Identities = 139/575 (24%), Positives = 251/575 (43%), Gaps = 90/575 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCE-----------LRLLEKGQINVRRN 320
L + ++ +P +IA+ L E V QN+++L C + E G R
Sbjct: 369 LRIDQVAVPYRIAKILTFPERVTTQNKKHLQDCIRNGPDVHPGANYVIDRESGFKRFLRF 428
Query: 321 GNPVVLYKKEDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPI 380
GN + +DL+IGDI R L D D VL NR PS+H+ S++A V+V P ++ N
Sbjct: 429 GNRNRI--ADDLKIGDIVERHLHDNDVVLFNRQPSLHKLSIMAHLVKVRPWRTL-RFNEC 485
Query: 381 CCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHL 440
C P DFDGD ++ ++PQ+ A+ E EL+ + L++ ++G +++ +QD +TAA+L
Sbjct: 486 VCGPYNADFDGDEMNLHVPQTEEAKTEALELMGIKNNLVSPRNGEPIIAATQDFITAAYL 545
Query: 441 L-----LEDGVGFNIYQVQQLEMLCNKELTSPAIFKAPSSNTPFWSGKQLFSMLL-PSKF 494
L D + ++ + +L PAI K W+GKQ+F++L+ P++F
Sbjct: 546 LSLKDTFLDRKSISNICCYMMDASTHIDLPPPAIIKPRC----LWTGKQVFTVLMKPNRF 601
Query: 495 DYAFPSND----------------------VFVKDGELISCSESSGWLRD-SENNVFQSL 531
+ D + +++ E+I+ + D ++++F +
Sbjct: 602 SKVLVNLDAKTRSFSRIKSKTPEMCPKDGYLMIRNSEIIAGVVDKSVVGDGKKDSLFYVI 661
Query: 532 VEHFQG-KILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAE 590
+ + + + + K +L GFS+ + D+ ++K ++ +Y
Sbjct: 662 LRDYGALEAAEAITRLSKMCARFLGNRGFSIGIEDVQPGKSLSSQKEILVNKAYATS--- 718
Query: 591 QACDFNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNI 650
+ ++ + L P +++ E +IS+ S+ D +
Sbjct: 719 -----DDFIMQYAKGILECQPGMDQEATL--------EAKISSTLSKVRDD--------V 757
Query: 651 QSLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNS 710
+ NS L M GSKG+ + + Q C+G Q + R+P G+
Sbjct: 758 GEICMDELGPANSPLIMATCGSKGSKINVSQMVACVGQQ---IISGKRVP-----DGFQD 809
Query: 711 QKGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--P 768
+ H + S L A V +SF +GL P E H+++ R+
Sbjct: 810 RSLPHFHKNSKHPL-------AKGFVSNSFYSGLTPTEFLFHAISGREGLVDTAVKTAET 862
Query: 769 GTLTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
G ++RRLM + D+ AYDGTVR+ + ++QF Y
Sbjct: 863 GYMSRRLMKSLEDLSSAYDGTVRS-SNSDVVQFVY 896
Score = 45.4 bits (106), Expect = 8e-04
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
+G N C TCG + C GHFG +K + H + ILQ IC C S+
Sbjct: 57 MGTSNKQINCATCG-ESMADCMGHFGYVKLALPVFHIGYFKATLTILQNICKDCSSV 112
>RPA1_SULAC (P11512) DNA-directed RNA polymerase subunit A' (EC
2.7.7.6)
Length = 880
Score = 140 bits (353), Expect = 2e-32
Identities = 150/572 (26%), Positives = 257/572 (44%), Gaps = 93/572 (16%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEK---GQINVRRNGNPVVLYK 328
L + E+GIP IA L V E V N + + + +K ++ +G + L
Sbjct: 332 LSIDEVGIPYTIARMLTVPERVTNINIERIRQYI-INGPDKWPGANYVIKPDGRRIDLRY 390
Query: 329 KED-------LQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPIC 381
+D + G + R LVDGD VL NR PS+H+ SM+A VRVLP +N +
Sbjct: 391 VKDRKELASSITAGYVVERHLVDGDVVLFNRQPSLHRISMMAHKVRVLP-GRTFRLNLLD 449
Query: 382 CSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHLL 441
C P DFDGD ++ ++PQS A E EL+ + + +I + GG ++ QD ++ A+LL
Sbjct: 450 CPPYNADFDGDEMNLHVPQSEEAIAEARELMLVHKNIITPRYGGPIIGGGQDYISGAYLL 509
Query: 442 LEDGVGFNIYQVQQLEMLCN-----KELTSPAIFKAPSSNTPFWSGKQLFSMLLPSKFDY 496
V + V+++ + EL PAI AP P+++GKQ+ S+ LP F++
Sbjct: 510 ---SVKTTLLTVEEVATILGVTDFVGELGEPAIL-APK---PYYTGKQVISLFLPKDFNF 562
Query: 497 AFPSN-----------------DVFVKDGELIS--CSESSGWLRDSENNVFQSLVEHFQG 537
P+N + +K+G L+ + + + E+ + S+ E+
Sbjct: 563 HGPANISKGPRACKDEICPHDSFIVIKNGLLLEGVFDKKAIGNQQPESMLHWSIREYGTE 622
Query: 538 KILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGL-RVAEQACDFN 596
++ K +L M GF+++L D+ + + A+ + +I G +V E FN
Sbjct: 623 YGKWLMDNVFKMFIRFLEMRGFTMTLEDITIPDE--AQNEITTKIKEGYSQVDEYIRKFN 680
Query: 597 QLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLADK 656
+ ++ E E ++ +D+L R+++ + +D F +V+
Sbjct: 681 EGQLEPIPG--RTIEESLESYILDTLDKL---RKVAGEIATKYLDPFNNVY--------- 726
Query: 657 HACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQH---SLVRLSYRIPRELSCAGWNSQKG 713
M G++G+ L + Q + LG Q +R YR R LS +
Sbjct: 727 ---------IMAITGARGSELNITQMTALLGQQSVRGERIRRGYR-ERTLSLFKYGD--- 773
Query: 714 LHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDS--SFSDNADLPGTL 771
+ P+ A V++SF+ GL+P E F H+ R+ + G +
Sbjct: 774 ----------IAPE----ARGFVKNSFMRGLSPYEMFFHAAGGREGLVDTAVKTSQSGYM 819
Query: 772 TRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
RRL+ + D+ YDGTVR+LYG+ ++Q Y
Sbjct: 820 QRRLINALSDLRIEYDGTVRSLYGD-IVQVVY 850
Score = 35.8 bits (81), Expect = 0.61
Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 5/110 (4%)
Query: 39 GQVTCSDLGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPA 98
G V LG+ C CG+ C GHFG I+ ++H ++ I + L+ C
Sbjct: 42 GGVMDPKLGVIEPGEKCPVCGNT-LAGCPGHFGHIELIKPVIHIGYVKHIYDFLRSTCWR 100
Query: 99 CKSIRQEIRVKVCLLPIVKVLFHAYSVLNHSLDTIISPKVANIAVGSLSC 148
C I++K L K +++A + S + + I++ +L C
Sbjct: 101 C----GRIKIKEQDLERYKRIYNAIKLRWPSAARRLVEYIKKISIKNLEC 146
>RPB1_MOUSE (P08775) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6) (RPB1)
Length = 1970
Score = 139 bits (349), Expect = 5e-32
Identities = 148/571 (25%), Positives = 252/571 (43%), Gaps = 91/571 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQIN-------VRRNGNPV 324
L + ++G+P IA + +E V N L L+ +G +R NG+ +
Sbjct: 373 LSIDQVGVPRSIAANMTFAEIVTPFNIDRLQ-----ELVRRGNSQYPGAKYIIRDNGDRI 427
Query: 325 VLY---KKEDL--QIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINP 379
L K DL Q G R + DGD V+ NR P++H+ SM+ VR+LP S+ +N
Sbjct: 428 DLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTF-RLNL 486
Query: 380 ICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAH 439
+P DFDGD ++ ++PQS+ R E+ EL + R ++ QS ++ + QD+LTA
Sbjct: 487 SVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVR 546
Query: 440 LLLEDGVGFNIYQVQQLEMLCNK---ELTSPAIFKAPSSNTPFWSGKQLFSMLLP----- 491
+ V +V L M + ++ PAI K P W+GKQ+FS+++P
Sbjct: 547 KFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKP----RPLWTGKQIFSLIIPGHINC 602
Query: 492 -------------SKFDYAFPSN-DVFVKDGELIS---CSESSGWLRDSENNVFQSLVEH 534
+ + P + V V++GELI C +S G S ++ + H
Sbjct: 603 IRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGH 662
Query: 535 FQGKILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACD 594
++ Q + WL + G ++ + D S +Y ++I ++ A+Q D
Sbjct: 663 DITRLF--YSNIQTVINNWLLIEGHTIGIGDSIADSKTY------QDIQNTIKKAKQ--D 712
Query: 595 FNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLA 654
+++ +++ L +P + R E Q++ + A S A
Sbjct: 713 VIEVIEKAHNNELEPTPG--------NTLRQTFENQVNRILNDAR--------DKTGSSA 756
Query: 655 DKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGL 714
K + N+F +M +G+KG+ + + Q +G Q+ + RIP G+ +
Sbjct: 757 QKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGK---RIP-----FGFKHRTLP 808
Query: 715 HSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--PGTLT 772
H ++ D P+ + VE+S+L GL P E F H++ R+ G +
Sbjct: 809 HFIK---DDYGPE----SRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQ 861
Query: 773 RRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
RRL+ M + YD TVRN NQ++Q Y
Sbjct: 862 RRLIKSMESVMVKYDATVRNSI-NQVVQLRY 891
Score = 34.3 bits (77), Expect = 1.8
Identities = 14/48 (29%), Positives = 24/48 (49%), Gaps = 1/48 (2%)
Query: 55 CTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
C TC + C GHFG I+ + H F+ + ++L+ +C C +
Sbjct: 71 CQTCAG-NMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKL 117
Score = 32.0 bits (71), Expect = 8.7
Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 38/161 (23%)
Query: 822 GEPVGALSACAVSEAA---------YSALSQPISLLEASPLLNLKNVLECGSRKKGGDQT 872
GE VGAL+A ++ E A Y+ +S L L L N+ KK +
Sbjct: 1084 GEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINI-----SKKPKTPS 1138
Query: 873 VSLFLSEKIGKQRNGFEYAALEVKNYLERYMFSNIVSTVMIIFTPQHCSQV--------- 923
+++FL +G+ E A ++ LE + + I + P S V
Sbjct: 1139 LTVFL---LGQSARDAERAK-DILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVN 1194
Query: 924 -----------KYSPWVCHFHLDKENVTRRKLEVHSIIDSL 953
+ SPW+ LD++++T RKL + I + +
Sbjct: 1195 VYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKI 1235
>RPB1_HUMAN (P24928) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6) (RPB1)
Length = 1970
Score = 139 bits (349), Expect = 5e-32
Identities = 148/571 (25%), Positives = 252/571 (43%), Gaps = 91/571 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQIN-------VRRNGNPV 324
L + ++G+P IA + +E V N L L+ +G +R NG+ +
Sbjct: 373 LSIDQVGVPRSIAANMTFAEIVTPFNIDRLQ-----ELVRRGNSQYPGAKYIIRDNGDRI 427
Query: 325 VLY---KKEDL--QIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINP 379
L K DL Q G R + DGD V+ NR P++H+ SM+ VR+LP S+ +N
Sbjct: 428 DLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTF-RLNL 486
Query: 380 ICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAH 439
+P DFDGD ++ ++PQS+ R E+ EL + R ++ QS ++ + QD+LTA
Sbjct: 487 SVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVR 546
Query: 440 LLLEDGVGFNIYQVQQLEMLCNK---ELTSPAIFKAPSSNTPFWSGKQLFSMLLP----- 491
+ V +V L M + ++ PAI K P W+GKQ+FS+++P
Sbjct: 547 KFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKP----RPLWTGKQIFSLIIPGHINC 602
Query: 492 -------------SKFDYAFPSN-DVFVKDGELIS---CSESSGWLRDSENNVFQSLVEH 534
+ + P + V V++GELI C +S G S ++ + H
Sbjct: 603 IRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGH 662
Query: 535 FQGKILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACD 594
++ Q + WL + G ++ + D S +Y ++I ++ A+Q D
Sbjct: 663 DITRLF--YSNIQTVINNWLLIEGHTIGIGDSIADSKTY------QDIQNTIKKAKQ--D 712
Query: 595 FNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLA 654
+++ +++ L +P + R E Q++ + A S A
Sbjct: 713 VIEVIEKAHNNELEPTPG--------NTLRQTFENQVNRILNDAR--------DKTGSSA 756
Query: 655 DKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGL 714
K + N+F +M +G+KG+ + + Q +G Q+ + RIP G+ +
Sbjct: 757 QKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGK---RIP-----FGFKHRTLP 808
Query: 715 HSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--PGTLT 772
H ++ D P+ + VE+S+L GL P E F H++ R+ G +
Sbjct: 809 HFIK---DDYGPE----SRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQ 861
Query: 773 RRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
RRL+ M + YD TVRN NQ++Q Y
Sbjct: 862 RRLIKSMESVMVKYDATVRNSI-NQVVQLRY 891
Score = 34.3 bits (77), Expect = 1.8
Identities = 14/48 (29%), Positives = 24/48 (49%), Gaps = 1/48 (2%)
Query: 55 CTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
C TC + C GHFG I+ + H F+ + ++L+ +C C +
Sbjct: 71 CQTCAG-NMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKL 117
Score = 32.0 bits (71), Expect = 8.7
Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 38/161 (23%)
Query: 822 GEPVGALSACAVSEAA---------YSALSQPISLLEASPLLNLKNVLECGSRKKGGDQT 872
GE VGAL+A ++ E A Y+ +S L L L N+ KK +
Sbjct: 1084 GEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINI-----SKKPKTPS 1138
Query: 873 VSLFLSEKIGKQRNGFEYAALEVKNYLERYMFSNIVSTVMIIFTPQHCSQV--------- 923
+++FL +G+ E A ++ LE + + I + P S V
Sbjct: 1139 LTVFL---LGQSARDAERAK-DILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVN 1194
Query: 924 -----------KYSPWVCHFHLDKENVTRRKLEVHSIIDSL 953
+ SPW+ LD++++T RKL + I + +
Sbjct: 1195 VYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKI 1235
>RPC1_YEAST (P04051) DNA-directed RNA polymerase III largest subunit
(EC 2.7.7.6) (C160)
Length = 1460
Score = 136 bits (342), Expect = 3e-31
Identities = 146/582 (25%), Positives = 252/582 (43%), Gaps = 96/582 (16%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCE--------LRLLEKGQINVRRN--- 320
L + E+ +P ++A+ L E V R NR L L K + RRN
Sbjct: 387 LSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRY 446
Query: 321 GNPVVLYKKEDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPI 380
G+ + L K +LQIGD+ R L DGD VL NR PS+H+ S+++ ++ P + +N
Sbjct: 447 GDRMKLAK--NLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTF-RLNEC 503
Query: 381 CCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHL 440
C+P DFDGD ++ ++PQ+ AR E L+ + L+ +SG +++ +QD +T ++L
Sbjct: 504 VCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYL 563
Query: 441 LLEDGVGFNIYQVQQLEMLCNK-----ELTSPAIFKAPSSNTPF--WSGKQLFSMLL--- 490
+ ++ + QL + + ++ PAI K P+ W+GKQ+FS+L+
Sbjct: 564 ISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMK------PYYLWTGKQVFSLLIKPN 617
Query: 491 -----------------PSK---FDYAFPSND--VFVKDGELISCSESSGWLRD-SENNV 527
P K ND V ++ +++S L D +++V
Sbjct: 618 HNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGDGKKHSV 677
Query: 528 FQSLVEHF-QGKILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGL 586
F +++ + + + ++ K +L GFS+ ++D+ + D +K + EI+Y
Sbjct: 678 FYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPADDLKQKKEELVEIAY-- 735
Query: 587 RVAEQACDFNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHV 646
CD +L+ L P NE+ E +I S+ V
Sbjct: 736 ----HKCD--ELITLFNKGELETQPGCNEEQTL--------EAKIGGLLSK--------V 773
Query: 647 FRNIQSLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCA 706
+ + N+ L M GSKG+ L + Q +G Q + R+P
Sbjct: 774 REEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQ---IISGNRVPDGF--- 827
Query: 707 GWNSQKGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNAD 766
+ L +S T + K V +SF +GL+P E H+++ R+
Sbjct: 828 ---QDRSLPHFPKNSKTPQSK------GFVRNSFFSGLSPPEFLFHAISGREGLVDTAVK 878
Query: 767 L--PGTLTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSYDAE 806
G ++RRLM + D+ YD TVR N ++QF+Y +
Sbjct: 879 TAETGYMSRRLMKSLEDLSCQYDNTVRT-SANGIVQFTYGGD 919
Score = 44.7 bits (104), Expect = 0.001
Identities = 21/57 (36%), Positives = 30/57 (51%), Gaps = 1/57 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSI 102
+G+ +SS C TC + SC GHFG +K + H + +ILQ IC C +I
Sbjct: 58 MGVSSSSLECATCHG-NLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAI 113
>RPB1_CAEEL (P16356) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6)
Length = 1852
Score = 135 bits (341), Expect = 4e-31
Identities = 146/567 (25%), Positives = 244/567 (42%), Gaps = 87/567 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQIN---VRRNGNPVVLYK 328
L + +G+P IA+ L E V N L L+ +G + NG V L
Sbjct: 367 LPIDTVGVPRTIAQNLTFPEIVTPFNVDKLQ-----ELVNRGDTQYPGAKENGARVDLRY 421
Query: 329 KE-----DLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPICCS 383
LQ G R + DGD ++ NR P++H+ SM+ V++LP S+ +N S
Sbjct: 422 HPRAADLHLQPGYRVERHMKDGDIIVFNRQPTLHKMSMMGHRVKILPWSTF-RMNLSVTS 480
Query: 384 PLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHLLLE 443
P DFDGD ++ ++PQS+ R E+ E+ + RQLI Q+ ++ + QD+L A ++ +
Sbjct: 481 PYNADFDGDEMNLHLPQSLETRAEIEEIAMVPRQLITPQANKPVMGIVQDTLCAVRMMTK 540
Query: 444 DGVGFNIYQVQQLEMLC---NKELTSPAIFKAPSSNTPFWSGKQLFSMLLPSK------- 493
V + + L M + ++ PAI K P W+GKQ+FS+++P
Sbjct: 541 RDVFIDWPFMMDLLMYLPTWDGKVPQPAILKP----KPLWTGKQVFSLIIPGNVNVLRTH 596
Query: 494 -----------FDYAFPSN-DVFVKDGELISCSESSGWLRDSENNVFQSLVEHFQGKILD 541
+ + P + V ++ GEL+S S + S N+ + +I
Sbjct: 597 STHPDSEDSGPYKWISPGDTKVIIEHGELLSGIVCSKTVGKSAGNLLHVVTLELGYEIAA 656
Query: 542 VLHG-AQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLLV 600
+ Q + WL G ++ + D +Y +I +R A+Q D ++
Sbjct: 657 NFYSHIQTVINAWLIREGHTIGIGDTIADQATYL------DIQNTIRKAKQ--DVVDVIE 708
Query: 601 DHYSDFLSASPEE--NEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLADKHA 658
++D L +P + F LN R + + +Q S+ F
Sbjct: 709 KAHNDDLEPTPGNTLRQTFENKVNQILNDARDRTGSSAQKSLSEF--------------- 753
Query: 659 CKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLHSME 718
N+F +M +GSKG+ + + Q C+G Q+ + RIP G+ + H ++
Sbjct: 754 ---NNFKSMVVSGSKGSKINISQVIACVGQQNVEGK---RIP-----FGFRHRTLPHFIK 802
Query: 719 MSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--PGTLTRRLM 776
D P+ + VE+S+L GL P E F H++ R+ G + RRL+
Sbjct: 803 ---DDYGPE----SKGFVENSYLAGLTPSEFFFHAMGGREGLIDTAVKTAETGYIQRRLI 855
Query: 777 FFMRDMYDAYDGTVRNLYGNQLIQFSY 803
M + YDGTVRN Q++Q Y
Sbjct: 856 KAMESVMVNYDGTVRNSLA-QMVQLRY 881
Score = 32.3 bits (72), Expect = 6.7
Identities = 14/45 (31%), Positives = 23/45 (51%), Gaps = 1/45 (2%)
Query: 55 CTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPAC 99
C TC + C GHFG ++ + H F+ + +IL+ +C C
Sbjct: 66 CMTCAG-NLTDCPGHFGHLELAKPVFHIGFLTKTLKILRCVCFYC 109
>RPC1_HUMAN (O14802) DNA-directed RNA polymerase III largest subunit
(EC 2.7.7.6) (RPC155) (RPC1)
Length = 1391
Score = 135 bits (340), Expect = 6e-31
Identities = 147/578 (25%), Positives = 240/578 (41%), Gaps = 90/578 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCE--------LRLLEKGQINVRR---N 320
L + E+ +P +A+ L E VN+ N L + +++ ++R
Sbjct: 375 LRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFIQQRHTQMKRFLKY 434
Query: 321 GNPVVLYKKEDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPI 380
GN + ++L+ GDI R L+DGD VL NR PS+H+ S++A RV P N
Sbjct: 435 GNREKM--AQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKP-HRTFRFNEC 491
Query: 381 CCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHL 440
C+P DFDGD ++ ++PQ+ A+ E L+ L+ ++G L++ QD LT A+L
Sbjct: 492 VCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYL 551
Query: 441 LLEDGVGFNIYQVQQL--EMLCNKE------LTSPAIFKAPSSNTPFWSGKQLFSMLLPS 492
L F+ + Q+ +L K+ L P I K W+GKQ+FS++L
Sbjct: 552 LTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKP----VTLWTGKQIFSVILRP 607
Query: 493 KFDYAFPSN--------------------DVFVKDGELISCSESSGWL-RDSENNVFQSL 531
D +N V +++ EL+S S G L S+NN+F L
Sbjct: 608 SDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYIL 667
Query: 532 VEHF-QGKILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAE 590
+ + Q + D + + +LS GFS+ + D+ K + Y
Sbjct: 668 LRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGY------ 721
Query: 591 QACDFNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNI 650
+ C D Y + L+ + + T + E + + SV + +
Sbjct: 722 KKC-------DEYIEALNTGKLQQQPGCTAE------ETLEALILKELSV-----IRDHA 763
Query: 651 QSLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNS 710
S + K NS L M GSKG+ + + Q C+G Q + +G
Sbjct: 764 GSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQ--------------AISGSRV 809
Query: 711 QKGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADL--P 768
G + + K A V +SF +GL P E F H++ R+
Sbjct: 810 PDGFENRSLPHFEKHSKLP-AAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAET 868
Query: 769 GTLTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSYDAE 806
G + RRL+ + D+ YD TVR+ G+ +IQF Y +
Sbjct: 869 GYMQRRLVKSLEDLCSQYDLTVRSSTGD-IIQFIYGGD 905
Score = 37.4 bits (85), Expect = 0.21
Identities = 18/54 (33%), Positives = 23/54 (42%), Gaps = 1/54 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPAC 99
+G C TCG K+ C GH+G I H + + ILQ IC C
Sbjct: 60 MGTSEKDRPCETCG-KNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTC 112
>RPB1_ARATH (P18616) DNA-directed RNA polymerase II largest subunit
(EC 2.7.7.6)
Length = 1840
Score = 135 bits (340), Expect = 6e-31
Identities = 149/571 (26%), Positives = 253/571 (44%), Gaps = 92/571 (16%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKG----------QINVRRNG 321
+ + E+G+P IA L E V N + L L++ G + +R +G
Sbjct: 371 INIDELGVPWSIALNLTYPETVTPYNIERLK-----ELVDYGPHPPPGKTGAKYIIRDDG 425
Query: 322 NPVVL-YKKED----LQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVS 376
+ L Y K+ L++G R L DGD VL NR PS+H+ S++ +R++P S+
Sbjct: 426 QRLDLRYLKKSSDQHLELGYKVERHLQDGDFVLFNRQPSLHKMSIMGHRIRIMPYSTF-R 484
Query: 377 INPICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSL- 435
+N SP DFDGD ++ ++PQS R E+ EL+ + + +++ Q+ ++ + QD+L
Sbjct: 485 LNLSVTSPYNADFDGDEMNMHVPQSFETRAEVLELMMVPKCIVSPQANRPVMGIVQDTLL 544
Query: 436 -----TAAHLLLEDGVGFNIYQVQQLEMLCNKELTSPAIFKAPSSNTPFWSGKQLFSMLL 490
T +E V N + + ++ +PAI K P W+GKQ+F++++
Sbjct: 545 GCRKITKRDTFIEKDVFMNTLMWWE---DFDGKVPAPAILKP----RPLWTGKQVFNLII 597
Query: 491 PSKFD--------------YAFPSN-DVFVKDGELISCSESSGWLRDSENNVFQSLVEHF 535
P + + + P + V ++ GEL++ + L S ++ + E
Sbjct: 598 PKQINLLRYSAWHADTETGFITPGDTQVRIERGELLAGTLCKKTLGTSNGSLVHVIWEEV 657
Query: 536 QGKILDVLHGAQKALCE-WLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACD 594
G + L WL GF++ + D+ A + ME+I+ + A+ A
Sbjct: 658 GPDAARKFLGHTQWLVNYWLLQNGFTIGI------GDTIADSSTMEKINETISNAKTA-- 709
Query: 595 FNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLA 654
L+ L P R E +++ ++A DA S A
Sbjct: 710 VKDLIRQFQGKELDPEPGRTM--------RDTFENRVNQVLNKARDDA--------GSSA 753
Query: 655 DKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGL 714
K + N+ AM AGSKG+ + + Q + C+G Q+ + RIP G++ +
Sbjct: 754 QKSLAETNNLKAMVTAGSKGSFINISQMTACVGQQNVEGK---RIP-----FGFDGRTLP 805
Query: 715 HSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSD--NADLPGTLT 772
H + D P+ + VE+S+L GL P E F H++ R+ G +
Sbjct: 806 H---FTKDDYGPE----SRGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTSETGYIQ 858
Query: 773 RRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
RRL+ M D+ YDGTVRN G+ +IQF Y
Sbjct: 859 RRLVKAMEDIMVKYDGTVRNSLGD-VIQFLY 888
Score = 35.0 bits (79), Expect = 1.0
Identities = 18/64 (28%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 39 GQVTCSDLGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPA 98
G ++ + LG + C TC + + C GHFG ++ + H FM + I++ +C
Sbjct: 50 GGLSDTRLGTIDRKVKCETCMA-NMAECPGHFGYLELAKPMYHVGFMKTVLSIMRCVCFN 108
Query: 99 CKSI 102
C I
Sbjct: 109 CSKI 112
Score = 33.9 bits (76), Expect = 2.3
Identities = 52/253 (20%), Positives = 103/253 (40%), Gaps = 62/253 (24%)
Query: 812 DSYFREDIIG-GEPVGALSACAVSEAA---------YSALSQPISLLEASPLLNLKNVLE 861
+S F + ++ GE +G ++A ++ E A Y+ +S L L + NV
Sbjct: 1071 ESRFLQSLVAPGEMIGCVAAQSIGEPATQMTLNTFHYAGVSAKNVTLGVPRLREIINVA- 1129
Query: 862 CGSRKKGGDQTVSLFLSEKIGKQRNGFEYAALEVKNYLERYMFSNIVSTVMIIFTPQHCS 921
K+ ++S++L+ + K + G A V+ LE ++ + + P S
Sbjct: 1130 ----KRIKTPSLSVYLTPEASKSKEG----AKTVQCALEYTTLRSVTQATEVWYDPDPMS 1181
Query: 922 QV----------------------KYSPWVCHFHLDKENVTRRKLEVHSIIDSLYQQYDS 959
+ K SPW+ L++E + +KL + I + + ++D
Sbjct: 1182 TIIEEDFEFVRSYYEMPDEDVSPDKISPWLLRIELNREMMVDKKLSMADIAEKINLEFDD 1241
Query: 960 -----FRRES--KVILPSLKISSNEGGETSVGNEKDGEDCITVAVVEDSK---------- 1002
F ++ K+IL ++I ++EG + + +E ED + + +E +
Sbjct: 1242 DLTCIFNDDNAQKLIL-RIRIMNDEGPKGELQDE-SAEDDVFLKKIESNMLTEMALRGIP 1299
Query: 1003 --NSVQLDSVRKS 1013
N V + VRKS
Sbjct: 1300 DINKVFIKQVRKS 1312
>RPA1_THECE (P31813) DNA-directed RNA polymerase subunit A' (EC
2.7.7.6)
Length = 905
Score = 134 bits (336), Expect = 2e-30
Identities = 143/577 (24%), Positives = 250/577 (42%), Gaps = 87/577 (15%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEK---GQINVRRNGNPVVLYK 328
+ ++E+G+P IA L V E V N + L L EK + G + L +
Sbjct: 338 ISINEVGVPMAIAMELTVPEKVTEFNFEKLRKMV-LNGPEKYPGANYVIDPEGRRIRLME 396
Query: 329 K------EDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPICC 382
E L IG R L+DGD VL NR PS+H+ S++A VRV+P + +N C
Sbjct: 397 NNLETVAEKLDIGWTVERHLLDGDVVLFNRQPSLHRMSIMAHRVRVMPYRTF-RLNLSVC 455
Query: 383 SPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHLLL 442
P DFDGD ++ ++PQ+ A+ E L+ + +I+ + GG L++ QD ++ +LL
Sbjct: 456 PPYNADFDGDEMNLHVPQTEEAQAEAKILMEVQNHIISPRYGGPLIAGIQDHISGGYLLT 515
Query: 443 EDGVGFNIYQVQQLEMLCNKELTSPAIFKAPSSNTPFWSGKQLFSMLLPSKFDYAFPS-- 500
+G F +V+Q+ M ++ + WSGK +FS+LLP + +
Sbjct: 516 REGAYFERTEVEQMLMFAGVDVDRLPEPDKVENGVELWSGKTIFSLLLPKDLTIWYRNKL 575
Query: 501 --------------NDVFVKDGELISCSESSGWLRDSENNVFQSLVE-----HFQGKILD 541
+ + D E + G+ + ++ GK+LD
Sbjct: 576 CDEPGRCEALEKLIEEKLIPDEEEVRALAYDGFTYILNGKLLSGAIDKTAYGREDGKLLD 635
Query: 542 VL---HGAQKA---------LCEW-LSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRV 588
++ +G ++A L W ++ GF+ ++ D L +++ ++ I +R
Sbjct: 636 IIVREYGVERARQFLDQVTKLAIWVITHKGFTTAIDDEDLPTEA------LDRIREIIRE 689
Query: 589 AEQACDFNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFR 648
AE+ N+L+ + + L P + + E +I AA ++A
Sbjct: 690 AEER--VNRLIEAYRNGELEPIPGKTLEETL--------ESKIMAALAEAR--------D 731
Query: 649 NIQSLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGW 708
N +A+++ N + M K G++G +L + Q + LG Q + YR G+
Sbjct: 732 NAGKVAERYLGMSNHAVIMAKTGARGKILNITQMAAMLGQQSIRGKRLYR--------GY 783
Query: 709 NSQKGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDS--SFSDNAD 766
+ H L + A V +S+ +GL P E F H++ R+ +
Sbjct: 784 RERVLTH---FKPGDLGAR----ARGFVINSYKSGLTPQEYFFHAMGGREGLVDTAVRTA 836
Query: 767 LPGTLTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
G + RRL+ ++D+ YDGTVR+ G ++QF Y
Sbjct: 837 QSGYMQRRLINALQDLKVEYDGTVRDPTG-IIVQFRY 872
Score = 42.4 bits (98), Expect = 0.006
Identities = 29/102 (28%), Positives = 47/102 (45%), Gaps = 14/102 (13%)
Query: 15 LISYLCYLVLCLQE--KISALEINAP-----------GQVTCSDLGLPNSSYGCTTCGSK 61
+I + + +L QE K+SA EI P G + LG+ + C TCG++
Sbjct: 7 VIGSIDFGILSPQEIRKMSAAEITVPDTYDEDGYPIEGGLMDKRLGVIDPGLRCETCGAR 66
Query: 62 DRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPACKSIR 103
+ C GHFG ++ ++H F I +L+ C C I+
Sbjct: 67 AGE-CPGHFGHVELARPVIHVGFAKTIHRVLESTCRECGRIK 107
>RPA1_SULSO (Q980R2) DNA-directed RNA polymerase subunit A' (EC
2.7.7.6)
Length = 880
Score = 130 bits (328), Expect = 1e-29
Identities = 146/573 (25%), Positives = 248/573 (42%), Gaps = 95/573 (16%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEK---GQINVRRNGNPVVLYK 328
+ + E+G+P IA+ L V E + N + L + +K +R +G + L
Sbjct: 332 ISIDEVGVPEIIAKTLTVPERITPWNIEKLRQFV-INGPDKWPGANYVIRPDGRRIDLRY 390
Query: 329 KED-------LQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSINPIC 381
+D L G I R L+DGD VL NR PS+H+ SM+A VRVL +N +
Sbjct: 391 VKDRKELASTLAPGYIIERHLIDGDIVLFNRQPSLHRISMMAHRVRVLK-GLTFRLNLLV 449
Query: 382 CSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAAHLL 441
C P DFDGD ++ ++PQS A E E++ + + +I + GG ++ +QD ++ A+LL
Sbjct: 450 CPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNIITPRYGGPIIGAAQDYISGAYLL 509
Query: 442 LEDGVGFNIYQVQQLEMLCNK--ELTSPAIFKAPSSNTPFWSGKQLFSMLLPSKFDYAFP 499
+ QQ+ + + +L PAI AP +++GKQ+ S LP F++
Sbjct: 510 TVKTTLLTKEEAQQILGVADVKIDLGEPAIL-APRE---YYTGKQVISAFLPKDFNFHGQ 565
Query: 500 SN-----------------DVFVKDGELI-SCSESSGWLRDSENNVFQSLVEHFQ---GK 538
+N V +K+G L+ + ++ L++ + GK
Sbjct: 566 ANVSSGPRLCKNEDCPHDSYVVIKNGILLEGVFDKKAIGNQQPESILHWLIKEYSDEYGK 625
Query: 539 ILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQL 598
L + + ++ + GF++ L D+ L D +K + EI + + L
Sbjct: 626 WL--MDNLFRVFIRFVELQGFTMRLEDVSLGDD--VKKEIYNEID------RAKVEVDNL 675
Query: 599 LVDHYSDFLSASP-----EENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSL 653
+ + + L P E E ++ +D+L +S A +
Sbjct: 676 IQKYKNGELEPIPGRTLEESLENYILDTLDKL---------RSTAG------------DI 714
Query: 654 ADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKG 713
A K+ N M + G++G++L + Q + LG Q S G ++G
Sbjct: 715 ASKYLDPFNFAYVMARTGARGSVLNITQMAAMLGQQ--------------SVRGERIKRG 760
Query: 714 LHSMEMSSDTLEPKQ-SYIAHAVVESSFLTGLNPLECFVHSVTNRDS--SFSDNADLPGT 770
M + +P S A + SSF TGL P E F H+ R+ + G
Sbjct: 761 Y--MTRTLPHFKPYDISPEARGFIYSSFRTGLKPTELFFHAAGGREGLVDTAVRTSQSGY 818
Query: 771 LTRRLMFFMRDMYDAYDGTVRNLYGNQLIQFSY 803
+ RRL+ + D+ YDGTVR+LYG +++Q +Y
Sbjct: 819 MQRRLINALSDLRAEYDGTVRSLYG-EVVQVAY 850
Score = 37.7 bits (86), Expect = 0.16
Identities = 20/65 (30%), Positives = 30/65 (45%), Gaps = 1/65 (1%)
Query: 39 GQVTCSDLGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPA 98
G V LG+ C TCG+ +C GHFG I+ ++H + I E L+ C
Sbjct: 42 GSVMDPRLGVIEPGQKCPTCGNT-LGNCPGHFGHIELVRPVIHVGLVKHIYEFLKATCRR 100
Query: 99 CKSIR 103
C ++
Sbjct: 101 CGRVK 105
>RPC1_TRYBB (P08968) DNA-directed RNA polymerase III largest subunit
(EC 2.7.7.6)
Length = 1530
Score = 120 bits (301), Expect = 2e-26
Identities = 150/579 (25%), Positives = 250/579 (42%), Gaps = 95/579 (16%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKGQ--------INVRRNGNP 323
L++ E+ +P +A L + V + N + + RL+ G + + + G+
Sbjct: 378 LDVDELAVPLHVARVLTYPQRVFKANHELMR-----RLVRNGPHVHPGATTVYLAQEGSK 432
Query: 324 VVLYKKED-------LQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVS 376
L + D L +GDI R +++GD VL NR PS+H+ SM+A RVLP +
Sbjct: 433 KSLKNERDRHRLAARLAVGDIVERHVMNGDLVLFNRQPSLHRVSMMAHRARVLPFRTF-R 491
Query: 377 INPICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLT 436
N CC+P DFDGD ++ + Q+ AR E +L++ R +I+ ++G +++ +QD L
Sbjct: 492 FNECCCAPYNADFDGDEMNVHFVQTEKARAEALQLMSTARNIISAKNGEPIIACTQDFLA 551
Query: 437 AAHLLLEDGVGFNIYQVQQ-----LEMLCNKELTSPAIFKAPSSNTPFWSGKQ------- 484
AA+L+ V F+ + Q L + L PAI K W+GKQ
Sbjct: 552 AAYLVTSRDVFFDRGEFSQMVSHWLGPVTQFRLPIPAILKP----VELWTGKQLFELIVR 607
Query: 485 -------LFSMLLPSKFDYAFPSNDVFVKDGE---LISCSESSGWLRD-----SENNVFQ 529
L S P+KF Y ++G L SC S + +++ +F
Sbjct: 608 PSPEVDVLLSFEAPTKF-YTRKGKHDCAEEGYVAFLDSCFISGRLDKKLLGGGAKDGLFA 666
Query: 530 SL-VEHFQGKILDVLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRV 588
L G V+ + +L+ GFS+ L D+ + + +K + L
Sbjct: 667 RLHTIAGGGYTARVMSRIAQFTSRYLTNYGFSLGLGDVAPTPELNKQKAAV------LAR 720
Query: 589 AEQACDFNQLLVDHYSDFLSASPEENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFR 648
+ + CD L+ + + P K +++ RLN E +S + + A
Sbjct: 721 SVEVCD--GLIKSAKTGRMIPLPGLTVK-QSLEA-RLNTE--LSKVRDECGTAA------ 768
Query: 649 NIQSLADKHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGW 708
+Q+L+ +N+ L M ++GSKG+ L + Q C+G Q + R L
Sbjct: 769 -VQTLS----IHNNTPLIMVQSGSKGSALNIAQMMACVGQQ------TVSGKRILDAFQD 817
Query: 709 NSQKGLHSMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDSSFSDNADLP 768
S H E ++ A V +SF +GL+P E F H++ R+
Sbjct: 818 RSLPHFHRFE---------EAPAARGFVANSFYSGLSPTEFFFHTMAGREGLVDTAVKTA 868
Query: 769 --GTLTRRLMFFMRDMYDAYDGTVRNLYGNQL-IQFSYD 804
G + RRLM M ++ YDGTVRN G+ + ++F D
Sbjct: 869 ETGYIYRRLMKAMENLSVRYDGTVRNTKGDVIQLRFGED 907
>RPA1_METTH (O27125) DNA-directed RNA polymerase subunit A' (EC
2.7.7.6)
Length = 870
Score = 119 bits (299), Expect = 3e-26
Identities = 140/557 (25%), Positives = 237/557 (42%), Gaps = 95/557 (17%)
Query: 272 LELSEIGIPCQIAEALQVSEYVNRQNRQNLLYCCELRLLEKG-------QINVRRNGNPV 324
+ ++E+G+P IA + V YV N + +E G +R +G +
Sbjct: 328 ISINEVGVPEIIAREVTVPVYVTEWNIDRMR-----EYIENGPDVHPGANYVIRPDGRKI 382
Query: 325 VLYKK------EDLQIGDIFYRPLVDGDKVLINRPPSIHQHSMIALTVRVLPISSVVSIN 378
+Y + E+L+ G I R L DGD VL NR PS+H+ SM+A VRVLP + +N
Sbjct: 383 RIYNETKEVVLENLKPGYIVERHLKDGDIVLFNRQPSLHRMSMMAHQVRVLPYKT-FRLN 441
Query: 379 PICCSPLRGDFDGDCLHGYIPQSVGARVELNELVALDRQLINGQSGGNLLSLSQDSLTAA 438
C P DFDGD ++ ++ Q+ +R E L+ + +++ + GG ++ D ++ A
Sbjct: 442 LCVCPPYNADFDGDEMNMHVFQTEESRAEAKTLMRVQEHILSPRFGGPIIGGIHDHISGA 501
Query: 439 HLLLEDGVGFNIYQVQQLEMLCNKELTSPAIFKAPSSNTPFWSGKQLFSMLLPSKFDYAF 498
+LL F+ +V Q + A P S W+GK++FSM+LP + +
Sbjct: 502 YLLTRKSAVFSEEKVFQ--------ILKKAGLPLPDSRGRDWTGKEIFSMVLPDDLNMVY 553
Query: 499 PSNDVFVKDGELISCS-ESSGWLRDSENNVFQSLVEH-----FQGKILD----------- 541
+ +V K E + E+ ++ + +++ F GKILD
Sbjct: 554 RA-EVCRKCEECLEMECENDAYVVIENGQLISGVIDEKAYGAFAGKILDHIVKEYGTDAA 612
Query: 542 --VLHGAQKALCEWLSMTGFSVSLSDLYLSSDSYARKNMMEEISYGLRVAEQACDFNQLL 599
L A K + GF+ S +D + ++ E I LR AE D QL+
Sbjct: 613 REFLDSATKLAIAGIMHAGFTTSTNDEEIPEEA------RERIEAHLRNAEARVD--QLI 664
Query: 600 VDHYSDFLSASP----EENEKFVTVDVDRLNHERQISAAQSQASVDAFRHVFRNIQSLAD 655
+ + L P EE + + V ++ A+S +D
Sbjct: 665 EAYENGELEPLPGRSLEETLEMKIMQVLGEARDKSGEIAESYFDMD-------------- 710
Query: 656 KHACKDNSFLAMFKAGSKGNLLKLVQHSMCLGLQHSLVRLSYRIPRELSCAGWNSQKGLH 715
+N + M G++G++L L Q + C+G Q VR RI R G++++ H
Sbjct: 711 -----ENHAVIMALTGARGSMLNLTQITACVGQQS--VR-GGRISR-----GYDNRTLPH 757
Query: 716 SMEMSSDTLEPKQSYIAHAVVESSFLTGLNPLECFVHSVTNRDS--SFSDNADLPGTLTR 773
L K + V SS+ GL+P+E F H++ R+ + G + R
Sbjct: 758 ---FKKGELGAK----SRGFVHSSYKEGLDPIEFFFHAMGGREGLVDTAIRTAQSGYMQR 810
Query: 774 RLMFFMRDMYDAYDGTV 790
RL+ ++D+ +G V
Sbjct: 811 RLVNALQDLTVDENGRV 827
Score = 42.7 bits (99), Expect = 0.005
Identities = 21/54 (38%), Positives = 30/54 (54%), Gaps = 1/54 (1%)
Query: 46 LGLPNSSYGCTTCGSKDRKSCEGHFGAIKFPFTILHPYFMAEIAEILQKICPAC 99
LG+ + S C TCG+K + C GHFG+I ++H F I +IL+ C C
Sbjct: 51 LGVIDPSLRCRTCGAKGGE-CPGHFGSINLARPVIHVGFADTIHKILRSTCRKC 103
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.328 0.141 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113,939,758
Number of Sequences: 164201
Number of extensions: 4731775
Number of successful extensions: 13493
Number of sequences better than 10.0: 212
Number of HSP's better than 10.0 without gapping: 199
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 12920
Number of HSP's gapped (non-prelim): 370
length of query: 1025
length of database: 59,974,054
effective HSP length: 120
effective length of query: 905
effective length of database: 40,269,934
effective search space: 36444290270
effective search space used: 36444290270
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 71 (32.0 bits)
Medicago: description of AC146573.11