BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146573.1 + phase: 0
(483 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
C901_ARATH (Q42569) Cytochrome P450 90A1 (EC 1.14.-.-) 293 9e-79
CP85_LYCES (Q43147) Cytochrome P450 85 (EC 1.14.-.-) (Dwarf prot... 285 2e-76
C90C_ARATH (Q9M066) Cytochrome P450 90C1 (EC 1.14.-.-) (ROTUNDIF... 259 1e-68
T13H_TAXCU (Q8W4T9) Taxane 13-alpha-hydroxylase (EC 1.14.13.77) ... 221 3e-57
T10H_TAXCU (Q9AXM6) Taxane 10-beta-hydroxylase (EC 1.14.13.76) (... 219 9e-57
KAO2_ARATH (Q9C5Y2) Ent-kaurenoic acid oxidase 2 (EC 1.14.13.79)... 203 7e-52
KAO1_ARATH (O23051) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)... 191 3e-48
C881_MAIZE (Q43246) Cytochrome P450 88A1 (EC 1.14.-.-) (Dwarf3 p... 184 6e-46
CP26_BRARE (P79739) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic a... 178 2e-44
C120_SYNY3 (Q59990) Putative cytochrome P450 120 (EC 1.14.-.-) 178 2e-44
KAO1_HORVU (Q9AXH9) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)... 173 1e-42
CP26_CHICK (Q9PUB4) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic a... 171 4e-42
CP26_XENLA (O93323) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic a... 169 1e-41
C26A_HUMAN (Q9NR63) Cytochrome P450 26B1 (EC 1.14.-.-) (P450 26A... 167 7e-41
CP26_MOUSE (O55127) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic a... 155 3e-37
CP26_HUMAN (O43174) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic a... 155 3e-37
CPC7_RAT (P05179) Cytochrome P450 2C7 (EC 1.14.14.1) (CYPIIC7) (... 119 2e-26
CPZ6_CANFA (O62671) Cytochrome P450 2C41 (EC 1.14.14.1) (CYPIIC41) 118 4e-26
CP34_HUMAN (P08684) Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine... 117 7e-26
CPZ4_MOUSE (P56656) Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39) 117 9e-26
>C901_ARATH (Q42569) Cytochrome P450 90A1 (EC 1.14.-.-)
Length = 472
Score = 293 bits (749), Expect = 9e-79
Identities = 158/443 (35%), Positives = 252/443 (56%), Gaps = 6/443 (1%)
Query: 31 LPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVVSTDPDLNY 90
LPPGS+GLPL+GE+ Q + + PFI +R+ RYG +F T+L G P + S DP+ N
Sbjct: 31 LPPGSLGLPLIGETFQLIGAYKTENPEPFIDERVARYGSVFMTHLFGEPTIFSADPETNR 90
Query: 91 FIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLK-KMISEVE 149
F+ Q EGK+F+ YP + + G+ ++ + G ++K + ++ ++ +K ++ +++
Sbjct: 91 FVLQNEGKLFECSYPASICNLLGKHSLLLMKGSLHKRMHSLTMSFANSSIIKDHLMLDID 150
Query: 150 QAACRTLQQASCQDSVELKEATETMIFDLTAKKLISYDPTESSENLRENFVAFIQGLISF 209
+ L S V L E + + F+LT K+L+S+DP E SE+LR+ ++ I+G S
Sbjct: 151 RLVRFNLD--SWSSRVLLMEEAKKITFELTVKQLMSFDPGEWSESLRKEYLLVIEGFFSL 208
Query: 210 PLNIPGTAYNKCLQGRKKAMKMLKNMLQERREMPRKQQMDFFDYVIEELRKEGTLLTEAI 269
PL + T Y K +Q R+K + L ++ +RRE + D + L + E I
Sbjct: 209 PLPLFSTTYRKAIQARRKVAEALTVVVMKRREEEEEGAERKKDMLAALLAADDGFSDEEI 268
Query: 270 ALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEY 329
+D + LL A +ETTS +T A+K L++ PL QL+EEHE I + + S + W +Y
Sbjct: 269 -VDFLVALLVAGYETTSTIMTLAVKFLTETPLALAQLKEEHEKIRAMKSDSYS-LEWSDY 326
Query: 330 KSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQD 389
KSM FT ++ ET R+ANI+ G+FR+A+ ++ KGY IP GW + AVHL+P ++D
Sbjct: 327 KSMPFTQCVVNETLRVANIIGGVFRRAMTDVEIKGYKIPKGWKVFSSFRAVHLDPNHFKD 386
Query: 390 PLVFNPSRWEGME-PSGATKHFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRPIKG 448
FNP RW+ +G + F FGGG R C G E A+V ++VFLH LVT + W P +
Sbjct: 387 ARTFNPWRWQSNSVTTGPSNVFTPFGGGPRLCPGYELARVALSVFLHRLVTGFSWVPAEQ 446
Query: 449 GNIVRTPGLQFPNGFHVQITEKD 471
+V P + + + + +D
Sbjct: 447 DKLVFFPTTRTQKRYPIFVKRRD 469
>CP85_LYCES (Q43147) Cytochrome P450 85 (EC 1.14.-.-) (Dwarf
protein)
Length = 464
Score = 285 bits (728), Expect = 2e-76
Identities = 154/472 (32%), Positives = 259/472 (54%), Gaps = 18/472 (3%)
Query: 2 WVLCLGALVTICIITRWVYRWRNPSCNGK-LPPGSMGLPLLGESLQFFSPNTSCDIPPFI 60
+++ L + +CI + RW N K LPPG+MG PL GE+ +F P F+
Sbjct: 4 FLIFLSSFFGLCIFCTALLRWNQVKYNQKNLPPGTMGWPLFGETTEFLKLG-----PSFM 58
Query: 61 RKRMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSL 120
+ + RYG FK++++G P +VS D +LN +I E K YP + +I G+ N+ ++
Sbjct: 59 KNQRARYGSFFKSHILGCPTIVSMDSELNRYILVNEAKGLVPGYPQSMIDILGKCNIAAV 118
Query: 121 HGFMYKYLKNMMLNLFGPESLKKMISEVEQAACRTLQQASCQDSVELKEATETMIFDLTA 180
+G +KY++ +L+L P ++ + R+ ++++E T M F +
Sbjct: 119 NGSAHKYMRGALLSLISPTMIRDQLLPKIDEFMRSHLTNWDNKVIDIQEKTNKMAFLSSL 178
Query: 181 KKLISYDPTESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQERR 240
K++ + T ++ F + G +S P+N+P T Y++ Q RK + +L+ +++ERR
Sbjct: 179 KQIAGIESTSLAQEFMSEFFNLVLGTLSLPINLPNTNYHRGFQARKIIVNLLRTLIEERR 238
Query: 241 EMPRKQQMDFFDYVIEELRKEGTL--LTEAIALDLMFVLLFASFETTSQALTYAIKLLSD 298
++ Q D Y++ E E T LT+ +DL+ +L++ +ET S A+K L D
Sbjct: 239 AS-KEIQHDMLGYLMNE---EATRFKLTDDEMIDLIITILYSGYETVSTTSMMAVKYLHD 294
Query: 299 NPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKALR 358
+P V ++L++EH AI E+++ P + + +Y+SM FT +I ET+RLA IV G+ RK +
Sbjct: 295 HPKVLEELRKEHMAIREKKK-PEDPIDYNDYRSMRFTRAVILETSRLATIVNGVLRKTTQ 353
Query: 359 EINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRW--EGMEPSGATKHFLAFGGG 416
++ GY IP GW I V ++ +P Y DP FNP RW + +E + FL FGGG
Sbjct: 354 DMEINGYIIPKGWRIYVYTRELNYDPRLYPDPYSFNPWRWMDKSLEHQNS---FLVFGGG 410
Query: 417 MRFCVGTEFAKVQMAVFLHCLVTKYRWRPIKGGNIVRTPGLQFPNGFHVQIT 468
R C G E +++ FLH VTKYRW I G +++ P ++ PNG ++++
Sbjct: 411 TRQCPGKELGVAEISTFLHYFVTKYRWEEIGGDKLMKFPRVEAPNGLRIRVS 462
>C90C_ARATH (Q9M066) Cytochrome P450 90C1 (EC 1.14.-.-)
(ROTUNDIFOLIA3)
Length = 524
Score = 259 bits (661), Expect = 1e-68
Identities = 146/449 (32%), Positives = 244/449 (53%), Gaps = 8/449 (1%)
Query: 29 GKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVVSTDPDL 88
G +P GS+G P++GE+L F + S F+ KR YG +FKTN++G P+++STD ++
Sbjct: 67 GMIPNGSLGWPVIGETLNFIACGYSSRPVTFMDKRKSLYGKVFKTNIIGTPIIISTDAEV 126
Query: 89 NYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLKKMIS-E 147
N + Q G F YP + TE+ G+ ++ S++G K L ++ LK I+ +
Sbjct: 127 NKVVLQNHGNTFVPAYPKSITELLGENSILSINGPHQKRLHTLIGAFLRSPHLKDRITRD 186
Query: 148 VEQAACRTLQQASCQDSVELKEATETMIFDLTAKKLISYDPTESSENLRENFVAFIQGLI 207
+E + TL + V +++ + M F++ K L+S P E L+ F FI+GLI
Sbjct: 187 IEASVVLTLASWAQLPLVHVQDEIKKMTFEILVKVLMSTSPGEDMNILKLEFEEFIKGLI 246
Query: 208 SFPLNIPGTAYNKCLQGRKKAMKMLKNMLQERREMPRKQQMDFFDYVIEELRKEGTLLTE 267
P+ PGT K L+ +++ +KM+K +++ER ++ D V LR G +
Sbjct: 247 CIPIKFPGTRLYKSLKAKERLIKMVKKVVEER-QVAMTTTSPANDVVDVLLRDGGDSEKQ 305
Query: 268 AIALDLM----FVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSG 323
+ D + ++ ET A+T A+K LSDNP+ +L EE+ + R+
Sbjct: 306 SQPSDFVSGKIVEMMIPGEETMPTAMTLAVKFLSDNPVALAKLVEENMEMKRRKLELGEE 365
Query: 324 VTWQEYKSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLN 383
W +Y S++FT +I ET R+ANI+ G++RKAL+++ KGY IP GW ++ +VH++
Sbjct: 366 YKWTDYMSLSFTQNVINETLRMANIINGVWRKALKDVEIKGYLIPKGWCVLASFISVHMD 425
Query: 384 PAKYQDPLVFNPSRWEGMEPS-GATKHFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYR 442
Y +P F+P RW+ + S ++ F FGGG R C G E +K+++++FLH LVT+Y
Sbjct: 426 EDIYDNPYQFDPWRWDRINGSANSSICFTPFGGGQRLCPGLELSKLEISIFLHHLVTRYS 485
Query: 443 WRPIKGGNIVRTPGLQFPNGFHVQITEKD 471
W + IV P ++ +++ D
Sbjct: 486 W-TAEEDEIVSFPTVKMKRRLPIRVATVD 513
>T13H_TAXCU (Q8W4T9) Taxane 13-alpha-hydroxylase (EC 1.14.13.77)
(Cytochrome P450 725A2)
Length = 485
Score = 221 bits (563), Expect = 3e-57
Identities = 119/417 (28%), Positives = 214/417 (50%), Gaps = 6/417 (1%)
Query: 30 KLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVVSTDPDLN 89
KLPPG++G PL+GE+LQF S FI +RM ++G +FKT+++G P VV P N
Sbjct: 37 KLPPGNLGFPLVGETLQFVRSLGSSTPQQFIEERMSKFGDVFKTSIIGHPTVVLCGPAGN 96
Query: 90 YFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLKKMISEVE 149
+ E K+ Q +P + ++ G+ +G G ++ ++ + GP++L+ +++
Sbjct: 97 RLVLSNENKLVQMSWPSSMMKLIGEDCLGGKTGEQHRIVRAALTRFLGPQALQNHFAKMS 156
Query: 150 QAACRTLQQA-SCQDSVELKEATETMIFDLTAKKLISYDPTESSENLRENFVAFIQGLIS 208
R + + +D + + ++F + ++ E L + G S
Sbjct: 157 SGIQRHINEKWKGKDEATVLPLVKDLVFSVASRLFFGITEEHLQEQLHNLLEVILVGSFS 216
Query: 209 FPLNIPGTAYNKCLQGRKKAMKMLKNMLQERREMPR----KQQMDFFDYVIEELRKEGTL 264
PLNIPG +Y+K +Q R ++ +++++RR R + D ++ + G
Sbjct: 217 VPLNIPGFSYHKAIQARATLADIMTHLIEKRRNELRAGTASENQDLLSVLLTFTDERGNS 276
Query: 265 LTEAIALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGV 324
L + LD +LL S+++T+ LT IK+L+ +P ++++ +E IL + +
Sbjct: 277 LADKEILDNFSMLLHGSYDSTNSPLTMLIKVLASHPESYEKVAQEQFGILSTKME-GEEI 335
Query: 325 TWQEYKSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLNP 384
W++ K M +++Q++ ET R+ + G FRKA+ +I++ GYTIP GW ++ +
Sbjct: 336 AWKDLKEMKYSWQVVQETLRMYPPIFGTFRKAITDIHYNGYTIPKGWKLLWTTYSTQTKE 395
Query: 385 AKYQDPLVFNPSRWEGMEPSGATKHFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKY 441
++D F PSR+E +L FGGGMR C G EFAK++ +FLH V +
Sbjct: 396 EYFKDADQFKPSRFEEEGKHVTPYTYLPFGGGMRVCPGWEFAKMETLLFLHHFVKAF 452
>T10H_TAXCU (Q9AXM6) Taxane 10-beta-hydroxylase (EC 1.14.13.76)
(5-alpha-taxadienol-10-beta-hydroxylase) (Cytochrome
P450 725A1)
Length = 497
Score = 219 bits (559), Expect = 9e-57
Identities = 128/445 (28%), Positives = 223/445 (49%), Gaps = 9/445 (2%)
Query: 3 VLCLGALVTICIITRWVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRK 62
+L L + II ++R+ + S + KLPPG +G PL+GE++Q S F
Sbjct: 23 ILSLTLAPILAIILLLLFRYNHRS-SVKLPPGKLGFPLIGETIQLLRTLRSETPQKFFDD 81
Query: 63 RMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHG 122
R+K++GP++ T+L+G P VV P N + E K+ + P +F ++ G+ ++ + G
Sbjct: 82 RLKKFGPVYMTSLIGHPTVVLCGPAGNKLVLSNEDKLVEMEGPKSFMKLIGEDSIVAKRG 141
Query: 123 FMYKYLKNMMLNLFGPESLKKMISEVEQAACRTLQQA-SCQDSVELKEATETMIFDLTAK 181
++ L+ + G ++L+ + + + +D V++ +IF + +
Sbjct: 142 EDHRILRTALARFLGAQALQNYLGRMSSEIGHHFNEKWKGKDEVKVLPLVRGLIFSIAST 201
Query: 182 KLISYDPTESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQERRE 241
+ + L + G +S PL+ PGT Y K LQ R K ++L ++++ RR
Sbjct: 202 LFFDVNDGHQQKQLHHLLETILVGSLSVPLDFPGTRYRKGLQARLKLDEILSSLIKRRRR 261
Query: 242 MPR----KQQMDFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLLS 297
R D ++ ++G LT+ LD + AS++TT + KLL
Sbjct: 262 DLRSGIASDDQDLLSVLLTFRDEKGNSLTDQGILDNFSAMFHASYDTTVAPMALIFKLLY 321
Query: 298 DNPLVF-KQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKA 356
NP K QE+ E I ++E ++W++ KSM +T+Q + E+ R+ V GIFRKA
Sbjct: 322 SNPEYHEKVFQEQLEIIGNKKEGEE--ISWKDLKSMKYTWQAVQESLRMYPPVFGIFRKA 379
Query: 357 LREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGATKHFLAFGGG 416
+ +I++ GYTIP GW ++ P HL + +P F PSR+E ++ FGGG
Sbjct: 380 ITDIHYDGYTIPKGWRVLCSPYTTHLREEYFPEPEEFRPSRFEDEGRHVTPYTYVPFGGG 439
Query: 417 MRFCVGTEFAKVQMAVFLHCLVTKY 441
+R C G EF+K+++ +F+H V +
Sbjct: 440 LRTCPGWEFSKIEILLFVHHFVKNF 464
>KAO2_ARATH (Q9C5Y2) Ent-kaurenoic acid oxidase 2 (EC 1.14.13.79)
(AtKAO2) (Cytochrome P450 88A4)
Length = 489
Score = 203 bits (517), Expect = 7e-52
Identities = 128/455 (28%), Positives = 226/455 (49%), Gaps = 18/455 (3%)
Query: 1 MW--VLCLGALVTICIITR---WVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCD 55
MW ++ LG V ++ R W+Y + LPPG +G P++G F + D
Sbjct: 9 MWFPLIILGLFVLKWVLKRVNVWIYVSKLGEKKHYLPPGDLGWPVIGNMWSFLRAFKTSD 68
Query: 56 IPPFIRKRMKRYGP--IFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFG 113
FI+ + RYG I+K ++ G P V+ T P+ + + W P + ++ G
Sbjct: 69 PESFIQSYITRYGRTGIYKAHMFGYPCVLVTTPETCRRVLTDDDAFHIGW-PKSTMKLIG 127
Query: 114 QQNVGSLHGFMYKYLKNMM-LNLFGPESLKKMISEVEQAACRTLQQASCQDSVELKEATE 172
+++ + +K L+ + + GPE+L I +E+ L++ S +E
Sbjct: 128 RKSFVGISFEEHKRLRRLTSAPVNGPEALSVYIQFIEETVNTDLEKWSKMGEIEFLSHLR 187
Query: 173 TMIFDLTAKKLISYDPTESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKML 232
+ F + +S + ++L + G+ + +N+PG AY++ L+ RKK +
Sbjct: 188 KLTFKVIMYIFLSSESEHVMDSLEREYTNLNYGVRAMGINLPGFAYHRALKARKKLVAAF 247
Query: 233 KNMLQERREMPRKQQM-----DFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQ 287
++++ RR RKQ + D D +I+ + G +L + +DL+ + L A E++
Sbjct: 248 QSIVTNRRNQ-RKQNISSNRKDMLDNLIDVKDENGRVLDDEEIIDLLLMYLNAGHESSGH 306
Query: 288 ALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQLITETARLAN 347
+A L+ ++P++ ++ +EE E I+++R P +T +E + M + Q+I ET R+
Sbjct: 307 LTMWATILMQEHPMILQKAKEEQERIVKKRA-PGQKLTLKETREMVYLSQVIDETLRVIT 365
Query: 348 IVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGAT 407
FR+A ++ GY IP GW ++ VHL+P Y DP F+PSRWEG P T
Sbjct: 366 FSLTAFREAKSDVQMDGYIIPKGWKVLTWFRNVHLDPEIYPDPKKFDPSRWEGYTPKAGT 425
Query: 408 KHFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYR 442
FL FG G C G + AK+++++FLH + KYR
Sbjct: 426 --FLPFGLGSHLCPGNDLAKLEISIFLHHFLLKYR 458
>KAO1_ARATH (O23051) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)
(AtKAO1) (Cytochrome P450 88A3)
Length = 490
Score = 191 bits (486), Expect = 3e-48
Identities = 119/447 (26%), Positives = 211/447 (46%), Gaps = 13/447 (2%)
Query: 5 CLGALVTICIITRWVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRM 64
C G + + W+Y LPPG +G P +G L F + D F R +
Sbjct: 19 CFGLNWLVRKVNVWLYESSLGENRHYLPPGDLGWPFIGNMLSFLRAFKTSDPDSFTRTLI 78
Query: 65 KRYGP--IFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHG 122
KRYGP I+K ++ G P ++ T D + + W P + E+ G+++ +
Sbjct: 79 KRYGPKGIYKAHMFGNPSIIVTTSDTCRRVLTDDDAFKPGW-PTSTMELIGRKSFVGISF 137
Query: 123 FMYKYLKNMMLN-LFGPESLKKMISEVEQAACRTLQQASCQDSVELKEATETMIFDLTAK 181
+K L+ + + G E+L I +E+ L + + E + F +
Sbjct: 138 EEHKRLRRLTAAPVNGHEALSTYIPYIEENVITVLDKWTKMGEFEFLTHLRKLTFRIIMY 197
Query: 182 KLISYDPTESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQERRE 241
+S + + L + A G+ + +NIPG AY++ L+ RK + ++++ ERR
Sbjct: 198 IFLSSESENVMDALEREYTALNYGVRAMAVNIPGFAYHRALKARKTLVAAFQSIVTERRN 257
Query: 242 MPRKQQM-----DFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLL 296
RKQ + D D ++ ++G L + +D++ + L A E++ + +A L
Sbjct: 258 Q-RKQNILSNKKDMLDNLLNVKDEDGKTLDDEEIIDVLLMYLNAGHESSGHTIMWATVFL 316
Query: 297 SDNPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKA 356
++P V ++ + E E IL+ R G++ +E + M F Q++ ET R+ FR+A
Sbjct: 317 QEHPEVLQRAKAEQEMILKSRPEGQKGLSLKETRKMEFLSQVVDETLRVITFSLTAFREA 376
Query: 357 LREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWE-GMEPSGATKHFLAFGG 415
++ GY IP GW ++ VH++P + DP F+P+RW+ G P FL FG
Sbjct: 377 KTDVEMNGYLIPKGWKVLTWFRDVHIDPEVFPDPRKFDPARWDNGFVPKAGA--FLPFGA 434
Query: 416 GMRFCVGTEFAKVQMAVFLHCLVTKYR 442
G C G + AK+++++FLH + KY+
Sbjct: 435 GSHLCPGNDLAKLEISIFLHHFLLKYQ 461
>C881_MAIZE (Q43246) Cytochrome P450 88A1 (EC 1.14.-.-) (Dwarf3
protein)
Length = 519
Score = 184 bits (466), Expect = 6e-46
Identities = 123/447 (27%), Positives = 211/447 (46%), Gaps = 14/447 (3%)
Query: 8 ALVTICIITRWVYRWRNPSCNG-----KLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRK 62
ALV + R + W + G +LPPG MG PL+G F S FI
Sbjct: 44 ALVVVDAAARRAHGWYREAALGAARRARLPPGEMGWPLVGGMWAFLRAFKSGKPDAFIAS 103
Query: 63 RMKRYGP--IFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSL 120
++R+G ++++ + P V+ T + + + W T + + V
Sbjct: 104 FVRRFGRTGVYRSFMFSSPTVLVTTAEGCKQVLMDDDAFVTGWPKATVALVGPRSFVAMP 163
Query: 121 HGFMYKYLKNMMLNLFGPESLKKMISEVEQAACRTLQQ-ASCQDSVELKEATETMIFDLT 179
+ + K + G ++L + +++ +L+ A SVE M F +
Sbjct: 164 YDEHRRIRKLTAAPINGFDALTGYLPFIDRTVTSSLRAWADHGGSVEFLTELRRMTFKII 223
Query: 180 AKKLISYDPTESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQER 239
+ + ++ L ++ G+ + +N+PG AY L+ R++ + +L+ +L ER
Sbjct: 224 VQIFLGGADQATTRALERSYTELNYGMRAMAINLPGFAYRGALRARRRLVAVLQGVLDER 283
Query: 240 REMPRKQQ----MDFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKL 295
R K +D D +IE + G L + +D++ + L A E++ +A
Sbjct: 284 RAARAKGVSGGGVDMMDRLIEAQDERGRHLDDDEIIDVLVMYLNAGHESSGHITMWATVF 343
Query: 296 LSDNPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRK 355
L +NP +F + + E EAI+ + G+T ++++ M + Q+I ET RL NI FR+
Sbjct: 344 LQENPDMFARAKAEQEAIMRSIPSSQRGLTLRDFRKMEYLSQVIDETLRLVNISFVSFRQ 403
Query: 356 ALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGATKHFLAFGG 415
A R++ GY IP GW + + +VH++P Y DP F+PSRWEG P T FLAFG
Sbjct: 404 ATRDVFVNGYLIPKGWKVQLWYRSVHMDPQVYPDPTKFDPSRWEGHSPRAGT--FLAFGL 461
Query: 416 GMRFCVGTEFAKVQMAVFLHCLVTKYR 442
G R C G + AK++++VFLH + Y+
Sbjct: 462 GARLCPGNDLAKLEISVFLHHFLLGYK 488
>CP26_BRARE (P79739) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic
acid-metabolizing cytochrome) (P450RAI) (Retinoic acid
4-hydroxylase)
Length = 492
Score = 178 bits (452), Expect = 2e-44
Identities = 127/471 (26%), Positives = 220/471 (45%), Gaps = 20/471 (4%)
Query: 4 LCLGALVTICIITRW---VYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFI 60
+ L L+ + + W + R +P+C LPPG+MGLP +GE+LQ F+
Sbjct: 14 IVLPVLLFLAAVKLWEMLMIRRVDPNCRSPLPPGTMGLPFIGETLQLILQRRK-----FL 68
Query: 61 RKRMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSL 120
R + ++YG I+KT+L G P V D I E K+ +P + I G + ++
Sbjct: 69 RMKRQKYGCIYKTHLFGNPTVRVMGADNVRQILLGEHKLVSVQWPASVRTILGSDTLSNV 128
Query: 121 HGFMYKYLKNMMLNLFGPESLKKMISEVEQAACRTLQQASCQDS-VELKEATETMIFDLT 179
HG +K K ++ F ++L+ I ++Q +Q+ +DS V + + ++F +
Sbjct: 129 HGVQHKNKKKAIMRAFSRDALEHYIPVIQQEVKSAIQEWLQKDSCVLVYPEMKKLMFRIA 188
Query: 180 AKKLISYDPTE---SSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGR----KKAMKML 232
+ L+ ++P + + L E F I+ L S P+++P + + L+ R K + +
Sbjct: 189 MRILLGFEPEQIKTDEQELVEAFEEMIKNLFSLPIDVPFSGLYRGLRARNFIHSKIEENI 248
Query: 233 KNMLQERREMPRKQQMDFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYA 292
+ +Q+ ++ D +IE R+ + + LLF ETT+ T
Sbjct: 249 RKKIQDDDNENEQKYKDALQLLIENSRRSDEPFSLQAMKEAATELLFGGHETTASTATSL 308
Query: 293 IKLLSDNPLVFKQLQEE-HEAILERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPG 351
+ L N V ++++EE E + P G++ + + +T +I ET R+ VPG
Sbjct: 309 VMFLGLNTEVVQKVREEVQEKVEMGMYTPGKGLSMELLDQLKYTGCVIKETLRINPPVPG 368
Query: 352 IFRKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRW--EGMEPSGATKH 409
FR AL+ GY IP GW ++ H + + F P R+ +G+E G+ +
Sbjct: 369 GFRVALKTFELNGYQIPKGWNVIYSICDTHDVADVFPNKEEFQPERFMSKGLE-DGSRFN 427
Query: 410 FLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRPIKGGNIVRTPGLQFP 460
++ FGGG R CVG EFAKV + +FL L W G ++T +P
Sbjct: 428 YIPFGGGSRMCVGKEFAKVLLKIFLVELTQHCNWILSNGPPTMKTGPTIYP 478
>C120_SYNY3 (Q59990) Putative cytochrome P450 120 (EC 1.14.-.-)
Length = 444
Score = 178 bits (452), Expect = 2e-44
Identities = 120/444 (27%), Positives = 217/444 (48%), Gaps = 23/444 (5%)
Query: 31 LPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVVSTDPDLNY 90
+PPG GLP LGE+L F + F +KR +++GPIFKT L G+ V+ + N
Sbjct: 13 IPPGDFGLPWLGETLNFLNDGD------FGKKRQQQFGPIFKTRLFGKNVIFISGALANR 66
Query: 91 FIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLKKMISEVEQ 150
F+F +E + FQ+ +P + + G + + G +++ + ++ F P +L + +++
Sbjct: 67 FLFTKEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDG 126
Query: 151 AACRTLQQASCQDSVELKEATETMIFDLTAKKLISYDPTESSENLRENFVAFIQGLISFP 210
L+Q + V M FD+ A L + + L F +IQGL S P
Sbjct: 127 IVQGYLEQWGKANEVIWYPQLRRMTFDVAA-TLFMGEKVSQNPQLFPWFETYIQGLFSLP 185
Query: 211 LNIPGTAYNKCLQGRKKAMKMLKNMLQERREMPRKQQMDFFDYVIEELRKEGTLLTEAIA 270
+ +P T + K + R + L+ +++ R++ P ++ D ++ L+
Sbjct: 186 IPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEE-DALGILLAARDDNNQPLSLPEL 244
Query: 271 LDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEYK 330
D + +LLFA ET + AL+ LL + + +++++E + +E +T + K
Sbjct: 245 KDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQE-----LTAETLK 299
Query: 331 SMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDP 390
M + Q++ E RL V G FR+ +++ F+G+ P GW + H +P Y DP
Sbjct: 300 KMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDP 359
Query: 391 LVFNPSRWEGMEPSGATKH-----FLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRP 445
F+P R+ P G+ H + FGGG+R C+G EFA+++M +F L+ ++ W
Sbjct: 360 EKFDPERF---TPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTL 416
Query: 446 IKGGN--IVRTPGLQFPNGFHVQI 467
+ G N +V TP + + V++
Sbjct: 417 LPGQNLELVVTPSPRPKDNLRVKL 440
>KAO1_HORVU (Q9AXH9) Ent-kaurenoic acid oxidase 1 (EC 1.14.13.79)
(gpr5)
Length = 499
Score = 173 bits (438), Expect = 1e-42
Identities = 110/426 (25%), Positives = 200/426 (46%), Gaps = 15/426 (3%)
Query: 29 GKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGP--IFKTNLVGRPVVVSTDP 86
G+LPPG MG PL+G F S FI +R+G +++ + P +++T P
Sbjct: 43 GRLPPGDMGWPLVGGMWAFLRAFKSGRPDSFIDSFARRFGRAGLYRAFMFSSPTIMATTP 102
Query: 87 DLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLN-LFGPESLKKMI 145
+ + + W P + G ++ ++ ++ L+ + + G ++L +
Sbjct: 103 EACKQVLMDDDAFVTGW-PKATVALIGPKSFVNMGYDEHRRLRKLTAAPINGFDALTSYL 161
Query: 146 SEVEQAACRTLQ---QASCQDSVELKEATETMIFDLTAKKLISYDPTESSENLRENFVAF 202
++ TL+ + E M F + + + ++ L +
Sbjct: 162 GFIDDTVVTTLRGWSERGGDGHFEFLTELRRMTFRIIVQIFMGGADERTAAELERTYTEL 221
Query: 203 IQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQERREMPRKQQ------MDFFDYVIE 256
G+ + +++PG AY+K ++ R++ + L+ +L ERR K +D D +I
Sbjct: 222 NYGMRAMAIDLPGFAYHKAIRARRRLVAALQRVLDERRARGGKTAAGAAAPVDMMDRLIA 281
Query: 257 ELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILER 316
+ G L + +D++ + L A E++ +A L +NP + + + E EAI+
Sbjct: 282 VEDEGGRRLQDDEIIDVLVMYLNAGHESSGHITMWATVFLQENPEILAKAKAEQEAIMRS 341
Query: 317 RENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPAGWAIMVC 376
G+T ++++ M + Q++ ET R NI FR+A R++ GY IP GW + +
Sbjct: 342 IPPGQKGLTLRDFRKMAYLSQVVDETLRFVNISFVSFRQATRDVFVNGYLIPKGWKVQLW 401
Query: 377 PPAVHLNPAKYQDPLVFNPSRWEGMEPSGATKHFLAFGGGMRFCVGTEFAKVQMAVFLHC 436
+VH++P Y DP F+PSRWEG P T FL FG G R C G + AK++++VFLH
Sbjct: 402 YRSVHMDPQVYPDPKKFDPSRWEGPPPRAGT--FLPFGLGTRLCPGNDLAKLEISVFLHH 459
Query: 437 LVTKYR 442
+ Y+
Sbjct: 460 FLLGYK 465
>CP26_CHICK (Q9PUB4) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic acid
degrading enzyme CYP26)
Length = 492
Score = 171 bits (433), Expect = 4e-42
Identities = 120/447 (26%), Positives = 212/447 (46%), Gaps = 14/447 (3%)
Query: 23 RNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVV 82
R+PSC LPPG+MGLP GE+LQ F++ + ++YG I+KT+L GRP V
Sbjct: 36 RDPSCPLPLPPGTMGLPFFGETLQMVLQRRK-----FLQMKRRKYGFIYKTHLFGRPTVR 90
Query: 83 STDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLK 142
+ I E ++ +P + I G + +LH +K+ K +++ F ++L+
Sbjct: 91 VMGAENVRHILLGEHRLVSVQWPASVRTILGSGCLSNLHNGQHKHRKKVIMQAFSRDALQ 150
Query: 143 KMISEVEQAACRTLQQ-ASCQDSVELKEATETMIFDLTAKKLISYDPTESS----ENLRE 197
+ +++ L Q + + + ++F + + L+ + P ++S + L E
Sbjct: 151 HYVPVIQEEVSACLAQWLGAGPCLLVYPEVKRLMFRIAMRILLGFQPRQASPDGEQQLVE 210
Query: 198 NFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQER--REMPRKQQMDFFDYVI 255
F I+ L S P+++P + + L+ R ++ ++ + R+ P D ++
Sbjct: 211 AFEEMIRNLFSLPIDVPFSGLYRGLRARNIIHAKIEENIRAKMARKEPEGGYKDALQLLM 270
Query: 256 EELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAI-L 314
E + G L + LLF ETT+ A T I L + V +++++E + L
Sbjct: 271 EHTQGNGEQLNMQELKESATELLFGGHETTASAATSLIAFLGLHHDVLQKVRKELQLKGL 330
Query: 315 ERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPAGWAIM 374
N + + + + +T +I ET RL+ VPG FR AL+ + GY IP GW ++
Sbjct: 331 LSGPNQEKQLNMEFLEQLKYTGCVIKETLRLSPPVPGGFRIALKTLELNGYQIPKGWNVI 390
Query: 375 VCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGATK-HFLAFGGGMRFCVGTEFAKVQMAVF 433
H + D FNP R+ P +++ F+ FGGG+R CVG EFAKV + +F
Sbjct: 391 YSICDTHDVADLFTDKDEFNPDRFMSPSPEDSSRFSFIPFGGGLRSCVGKEFAKVLLKIF 450
Query: 434 LHCLVTKYRWRPIKGGNIVRTPGLQFP 460
L W+ + G ++T + +P
Sbjct: 451 TVELARSCDWQLLNGPPTMKTGPIVYP 477
>CP26_XENLA (O93323) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic acid
degrading enzyme CYP26) (XCYP26) (Retinoic acid
converting enzyme) (RACE)
Length = 492
Score = 169 bits (428), Expect = 1e-41
Identities = 129/475 (27%), Positives = 218/475 (45%), Gaps = 26/475 (5%)
Query: 4 LCLGALVTICIITR------WVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIP 57
LC AL + ++T + R ++ +C LPPG+MGLP GE+LQ
Sbjct: 11 LCTLALPLLLLLTAAKLWEVYCLRRKDAACANPLPPGTMGLPFFGETLQMVLQRRR---- 66
Query: 58 PFIRKRMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNV 117
F++ + +YG I+KT+L G P V T + I E K+ +P + I G +
Sbjct: 67 -FLQVKRSQYGRIYKTHLFGSPTVRVTGAENVRQILMGEHKLVSVHWPASVRTILGAGCL 125
Query: 118 GSLHGFMYKYLKNMMLNLFGPESLKKMISEV-EQAACRT---LQQASCQDSVELKEATET 173
+LH +KY K ++ F E+L + ++ E+ C LQ C V + A +
Sbjct: 126 SNLHDNEHKYTKKVIAQAFSREALANYVPQMEEEVRCSVNLWLQSGPC---VLVYPAIKR 182
Query: 174 MIFDLTAKKLISYDP----TESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAM 229
M+F + + L+ DP E E L E F + L S P+++P + + L+ R
Sbjct: 183 MMFRIAMRLLLGCDPQRMDREQEETLLEAFEEMSRNLFSLPIDVPFSGLYRGLRARNLIH 242
Query: 230 KMLKNMLQER-REMPRKQQMDFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQA 288
++ ++E+ + P + D +I+ R+ G + + LLF TT+ A
Sbjct: 243 AQIEENIKEKLQREPDEHCKDALQLLIDYSRRNGEPINLQALKESATELLFGGHGTTASA 302
Query: 289 LTYAIKLLSDNPLVFKQLQEEHE--AILERRENPNSGVTWQEYKSMTFTFQLITETARLA 346
T L+ + V +++++E E +L + ++ + + + +T +I ET RL+
Sbjct: 303 ATSLTSFLALHKDVLEKVRKELETQGLLSTKPEEKKELSIEVLQQLKYTSCVIKETLRLS 362
Query: 347 NIVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGA 406
V G FR AL+ GY IP GW ++ H + D FNP R+ P +
Sbjct: 363 PPVAGGFRVALKTFVLNGYQIPKGWNVIYSIADTHGEADLFPDTDKFNPDRFLTPLPRDS 422
Query: 407 TKH-FLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRPIKGGNIVRTPGLQFP 460
++ F+ FGGG+R C+G EFAK+ + VF+ L W + G + T + P
Sbjct: 423 SRFGFIPFGGGVRCCIGKEFAKILLKVFVVELCRNCDWELLNGSPAMTTSPIICP 477
>C26A_HUMAN (Q9NR63) Cytochrome P450 26B1 (EC 1.14.-.-) (P450 26A2)
(P450 retinoic acid-inactivating 2) (P450RAI-2)
(Retinoic-acid metabolizing cytochrome)
Length = 512
Score = 167 bits (422), Expect = 7e-41
Identities = 115/441 (26%), Positives = 216/441 (48%), Gaps = 18/441 (4%)
Query: 5 CLGALVTICIITR--WVYRW---RNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPF 59
CL ++ + +++ W RW R+ SC +P GSMG PL+GE+ + + F
Sbjct: 18 CLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSG-----F 72
Query: 60 IRKRMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGS 119
R ++YG +FKT+L+GRP++ T + I E + + +P + + G V +
Sbjct: 73 QSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSN 132
Query: 120 LHGFMYKYLKNMMLNLFGPESLKKMISEVEQAACRTLQQ-ASCQDSVELKEATETMIFDL 178
G +++ + + +F E+L+ + +++ TL+ +S +++ + + + + F +
Sbjct: 133 SIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRM 192
Query: 179 TAKKLISYD-PTESSENLRENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQ 237
+ L+ + P E +L E + F+ + S P+++P + Y + +Q R+ K L+ ++
Sbjct: 193 AIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIR 252
Query: 238 ERREMPR-KQQMDFFDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLL 296
E+ + + K +D D +IE ++ G +T D L+FA++ TT+ A T I L
Sbjct: 253 EKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQL 312
Query: 297 SDNPLVFKQLQEEHEA--ILERRENPNSG-VTWQEYKSMTFTFQLITETARLANIVPGIF 353
+P V ++L++E A IL P G + + + +I E RL + G +
Sbjct: 313 LKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGY 372
Query: 354 RKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWE--GMEPSGATKHFL 411
R L+ G+ IP GW++M H ++D VF+P R+ E H+L
Sbjct: 373 RTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYL 432
Query: 412 AFGGGMRFCVGTEFAKVQMAV 432
FGGG+R C+G AK+ + V
Sbjct: 433 PFGGGVRTCLGKHLAKLFLKV 453
>CP26_MOUSE (O55127) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic
acid-metabolizing cytochrome) (P450RAI) (Retinoic acid
4-hydroxylase)
Length = 497
Score = 155 bits (391), Expect = 3e-37
Identities = 122/452 (26%), Positives = 209/452 (45%), Gaps = 19/452 (4%)
Query: 23 RNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVV 82
R+ SC LPPG+MG P GE+LQ F++ + ++YG I+KT+L GRP V
Sbjct: 36 RDRSCALPLPPGTMGFPFFGETLQMVLQRRK-----FLQMKRRKYGFIYKTHLFGRPTVR 90
Query: 83 STDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLK 142
D I E ++ +P + I G + +LH +K K +++ F E+L+
Sbjct: 91 VMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQAFSREALQ 150
Query: 143 KMISEVEQAACRTLQQ-ASC-QDSVELKEATETMIFDLTAKKLISYDP-----TESSENL 195
+ + + L+Q SC + + + + ++F + + L+ +P E + L
Sbjct: 151 CYVLVIAEEVSSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQL 210
Query: 196 RENFVAFIQGLISFPLNIPGTAYNKCLQGRKKA-MKMLKNMLQERREM----PRKQQMDF 250
E F + L S P+++P + + ++ R ++ +N+ + R + P D
Sbjct: 211 VEAFEEMTRNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQATEPDGGCKDA 270
Query: 251 FDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEH 310
+IE + G L LLF ETT+ A T I L P V ++++EE
Sbjct: 271 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEI 330
Query: 311 EAI-LERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPA 369
++ L + N ++ + + + + + +I ET RL VPG FR AL+ GY IP
Sbjct: 331 KSKGLLCKSNQDNKLDMETLEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPK 390
Query: 370 GWAIMVCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGATK-HFLAFGGGMRFCVGTEFAKV 428
GW ++ H + + FNP R+ P A++ F+ FGGG+R CVG EFAK+
Sbjct: 391 GWNVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKI 450
Query: 429 QMAVFLHCLVTKYRWRPIKGGNIVRTPGLQFP 460
+ +F L W+ + G ++T +P
Sbjct: 451 LLKIFTVELARHCDWQLLNGPPTMKTSPTVYP 482
>CP26_HUMAN (O43174) Cytochrome P450 26 (EC 1.14.-.-) (Retinoic
acid-metabolizing cytochrome) (P450 retinoic
acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid
4-hydroxylase)
Length = 497
Score = 155 bits (391), Expect = 3e-37
Identities = 119/452 (26%), Positives = 208/452 (45%), Gaps = 19/452 (4%)
Query: 23 RNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRYGPIFKTNLVGRPVVV 82
R+ SC LPPG+MG P GE+LQ F++ + ++YG I+KT+L GRP V
Sbjct: 36 RDRSCALPLPPGTMGFPFFGETLQMVLQRRK-----FLQMKRRKYGFIYKTHLFGRPTVR 90
Query: 83 STDPDLNYFIFQQEGKIFQSWYPDTFTEIFGQQNVGSLHGFMYKYLKNMMLNLFGPESLK 142
D I + ++ +P + I G + +LH +K K +++ F E+L+
Sbjct: 91 VMGADNVRRILLGDDRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALE 150
Query: 143 KMISEVEQAACRTLQQ-ASC-QDSVELKEATETMIFDLTAKKLISYDPT-----ESSENL 195
+ + + +L+Q SC + + + + ++F + + L+ +P +S + L
Sbjct: 151 CYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQL 210
Query: 196 RENFVAFIQGLISFPLNIPGTAYNKCLQGRKKAMKMLKNMLQE-----RREMPRKQQMDF 250
E F + L S P+++P + + ++ R ++ ++ R + D
Sbjct: 211 VEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDA 270
Query: 251 FDYVIEELRKEGTLLTEAIALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEH 310
+IE + G L LLF ETT+ A T I L P V ++++EE
Sbjct: 271 LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEL 330
Query: 311 EAI-LERRENPNSGVTWQEYKSMTFTFQLITETARLANIVPGIFRKALREINFKGYTIPA 369
++ L + N ++ + + + + + +I ET RL VPG FR AL+ GY IP
Sbjct: 331 KSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPK 390
Query: 370 GWAIMVCPPAVHLNPAKYQDPLVFNPSRWEGMEPSGATK-HFLAFGGGMRFCVGTEFAKV 428
GW ++ H + + FNP R+ P A++ F+ FGGG+R CVG EFAK+
Sbjct: 391 GWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKI 450
Query: 429 QMAVFLHCLVTKYRWRPIKGGNIVRTPGLQFP 460
+ +F L W+ + G ++T +P
Sbjct: 451 LLKIFTVELARHCDWQLLNGPPTMKTSPTVYP 482
>CPC7_RAT (P05179) Cytochrome P450 2C7 (EC 1.14.14.1) (CYPIIC7)
(P450F) (PTF1)
Length = 490
Score = 119 bits (298), Expect = 2e-26
Identities = 121/475 (25%), Positives = 207/475 (43%), Gaps = 52/475 (10%)
Query: 3 VLCLGALVTICIITRWVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRK 62
VL L +L+ + + WR S KLPPG LP++G LQ N S + F
Sbjct: 8 VLTLSSLILLSL-------WRQSSRRRKLPPGPTPLPIIGNFLQIDVKNISQSLTKF--- 57
Query: 63 RMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIF--QSWYP--DTFTEIFGQQNVG 118
K YGP+F L +P V+ + G+ F + YP + T+ FG +
Sbjct: 58 -SKTYGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMNENVTKGFG---IV 113
Query: 119 SLHGFMYKYLKNMMLNLF-----GPESLKKMISEVEQAACRTLQQ---ASCQDSVELKEA 170
+G +K ++ + F G +++ + E Q L++ + C S+ L A
Sbjct: 114 FSNGNRWKEMRRFTIMNFRNLGIGKRNIEDRVQEEAQCLVEELRKTKGSPCDPSLILNCA 173
Query: 171 TETMIFDLTAKKLISYDPTES-------SENLRENFVAFIQGLISFPLNI---PGTAYNK 220
+I +T + Y E +ENL+ ++Q SFP I PGT +
Sbjct: 174 PCNVICSITFQNHFDYKDKEMLTFMEKVNENLKIMSSPWMQVCNSFPSLIDYFPGTHHKI 233
Query: 221 CLQGRKKAMKMLKNMLQERREMPRKQQMDFFDYVIEELRKEGTL-----LTEAIALDLMF 275
+LK + + + + DF DY + + ++ + E + +M
Sbjct: 234 AKNINYMKSYLLKKIEEHQESLDVTNPRDFVDYYLIKQKQANNIEQSEYSHENLTCSIM- 292
Query: 276 VLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFT 335
L+ A ET S L YA+ LL P V ++QEE + ++ R +P Q+ K M +T
Sbjct: 293 DLIGAGTETMSTTLRYALLLLMKYPHVTAKVQEEIDRVIGRHRSP----CMQDRKHMPYT 348
Query: 336 FQLITETARLANIVPGIFRKALR-EINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFN 394
+I E R N VP A+ +I F+ Y IP G ++ +V + ++ +P +F+
Sbjct: 349 DAMIHEVQRFINFVPTNLPHAVTCDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPNPEMFD 408
Query: 395 PSRWEGMEPSGATK---HFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRPI 446
P + ++ +G K +FL F G R CVG A++Q+ +FL ++ + + +
Sbjct: 409 PGHF--LDENGNFKKSDYFLPFSAGKRACVGEGLARMQLFLFLTTILQNFNLKSL 461
>CPZ6_CANFA (O62671) Cytochrome P450 2C41 (EC 1.14.14.1) (CYPIIC41)
Length = 489
Score = 118 bits (295), Expect = 4e-26
Identities = 123/481 (25%), Positives = 208/481 (42%), Gaps = 65/481 (13%)
Query: 3 VLCLGALVTICIITRWVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRK 62
VLCL + + + W+ S GKLPPG LP +G LQ DI +
Sbjct: 8 VLCLSCCLLLSL-------WKQSSRKGKLPPGPTPLPFIGNILQLDK-----DINKSLSN 55
Query: 63 RMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTE-IFGQQNVGSLH 121
K YGP+F +P VV D G+ F + E + G +
Sbjct: 56 LSKAYGPVFTLYFGMKPTVVLHGYDAVKETLIDLGEEFSARGRFPIAEKVSGGHGIIFTS 115
Query: 122 GFMYKYLKNMMLNLFGPESLKK--MISEVEQAACRTLQQAS------CQDSVELKEATET 173
G +K ++ L + K + S V++ AC +++ C + L A+
Sbjct: 116 GNRWKEMRRFALTTLRNLGMGKSDLESRVQEEACYLVEELRKTNALPCDPTFVLGCASCN 175
Query: 174 MI--------FDLTAKKLISYDPTESSENLRENF----VAFIQGLISFPL---NIPGTAY 218
+I FD T + LI + E L ENF +IQ SFP +PG+ +
Sbjct: 176 VICSIIFQNRFDYTDQTLIGF-----LEKLNENFRILSSPWIQAYNSFPALLHYLPGS-H 229
Query: 219 NKCLQGRKKAMKMLKNMLQERRE-MPRKQQMDFFDYVIEELRKEGTLLT--------EAI 269
N + + ++E +E DF DY + ++ +E + I
Sbjct: 230 NTIFKNFAFIKSYILEKIKEHQESFDVNNPRDFIDYFLIKMEQEKHNQPLEFTFENLKTI 289
Query: 270 ALDLMFVLLFASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEY 329
A DL A ETTS L Y + LL +P V ++QEE + ++ R ++P+ Q+
Sbjct: 290 ATDLFG----AGTETTSTTLRYGLLLLLKHPEVTVKVQEEIDRVIGRHQSPHM----QDR 341
Query: 330 KSMTFTFQLITETARLANIVPGIFRKALR-EINFKGYTIPAGWAIMVCPPAVHLNPAKYQ 388
M +T ++ E R ++VP A+ ++ F+ Y IP G I++ +V + ++
Sbjct: 342 SRMPYTNAVLHEIQRYIDLVPNSLPHAVTCDVKFRNYVIPKGTTILISLSSVLSDEKEFP 401
Query: 389 DPLVFNPSRWEGMEPSGATK---HFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRP 445
P +F+P+ + ++ SG K +F+AF G R CVG A++++ +FL ++ K+ +P
Sbjct: 402 RPEIFDPAHF--LDDSGNFKKSDYFMAFSAGKRICVGEGLARMELFLFLTTILQKFTLKP 459
Query: 446 I 446
+
Sbjct: 460 L 460
>CP34_HUMAN (P08684) Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine
3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase) (NF-25)
(P450-PCN1)
Length = 502
Score = 117 bits (293), Expect = 7e-26
Identities = 115/468 (24%), Positives = 208/468 (43%), Gaps = 41/468 (8%)
Query: 9 LVTICIITRWVYRWRNPSCNGKLP-PGSMGLPLLGESLQFFSPNTSCDIPPFIRKRMKRY 67
L+ + ++ ++Y + KL PG LP LG L + D+ + K+Y
Sbjct: 13 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDM-----ECHKKY 67
Query: 68 GPIFKTNLVGRPVVVSTDPDLNYFIFQQEG-KIFQSWYPDTFTEI-FGQQNVGSLHGFMY 125
G ++ +PV+ TDPD+ + +E +F + P F + F + + +
Sbjct: 68 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP--FGPVGFMKSAISIAEDEEW 125
Query: 126 KYLKNMMLNLFGPESLKKMISEVEQ---AACRTLQ-QASCQDSVELKEATETMIFDLTAK 181
K L++++ F LK+M+ + Q R L+ +A V LK+ D+
Sbjct: 126 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 185
Query: 182 KLISYDPTESSENLRENFVA-------------FIQGLISFPLNIPGT-AYNKCLQGRKK 227
+ +S N ++ FV F + FP IP N C+ R+
Sbjct: 186 TSFGVN-IDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREV 244
Query: 228 A---MKMLKNMLQERREMPRKQQMDFFDYVIEELRKEGTLLTEAIA-LDLM---FVLLFA 280
K +K M + R E +K ++DF +I+ + T +A++ L+L+ + +FA
Sbjct: 245 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 304
Query: 281 SFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQLIT 340
+ETTS L++ + L+ +P V ++LQEE +A+L + P T+ M + ++
Sbjct: 305 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP----TYDTVLQMEYLDMVVN 360
Query: 341 ETARLANIVPGIFRKALREINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSRWEG 400
ET RL I + R +++ G IP GW +M+ A+H +P + +P F P R+
Sbjct: 361 ETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSK 420
Query: 401 MEPSGATKH-FLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRPIK 447
+ + FG G R C+G FA + M + L ++ + ++P K
Sbjct: 421 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468
>CPZ4_MOUSE (P56656) Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39)
Length = 490
Score = 117 bits (292), Expect = 9e-26
Identities = 115/472 (24%), Positives = 204/472 (42%), Gaps = 46/472 (9%)
Query: 3 VLCLGALVTICIITRWVYRWRNPSCNGKLPPGSMGLPLLGESLQFFSPNTSCDIPPFIRK 62
VL L +L+ + + WR G LPPG P++G LQ N S + F
Sbjct: 8 VLTLSSLILLSL-------WRQSCGRGSLPPGPTPFPIIGNFLQIDMKNFSQSLTNF--- 57
Query: 63 RMKRYGPIFKTNLVGRPVVVSTDPDLNYFIFQQEGKIFQSWYPDTFTE-IFGQQNVGSLH 121
K YGP+F L RP VV + G+ F E I + +
Sbjct: 58 -SKAYGPVFTLYLGSRPTVVLHGYEAVKEALIDHGEEFSDRGSIPMVEKINNGLGIVFSN 116
Query: 122 GFMYKYLKNMMLNL-----FGPESLKKMISEVEQAACRTLQQ---ASCQDSVELKEATET 173
G +K ++ L G +++ + E Q L++ + C + L A
Sbjct: 117 GNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCN 176
Query: 174 MIFDLTAKKLISYDPTE-------SSENLRENFVAFIQGLISFPLNI---PGTAYNKCLQ 223
+I + + Y + +EN++ ++Q +FPL I PG +++K L+
Sbjct: 177 VICSIIFQDRFDYKDKDFLMLMEKLNENVKILSSPWLQVCNNFPLLIDYCPG-SHHKVLK 235
Query: 224 GRKKAMKMLKNMLQERRE-MPRKQQMDFFDYVIEELRKEGTLLTEAIALDLMFV----LL 278
K L ++E +E + DF DY + + ++ + +L+ + L
Sbjct: 236 NVKYIRSYLLEKIKEHQESLDVTNPRDFIDYYLIKQKQANHIQQAEFSLENLACTINNLF 295
Query: 279 FASFETTSQALTYAIKLLSDNPLVFKQLQEEHEAILERRENPNSGVTWQEYKSMTFTFQL 338
A ETTS L YA+ LL P V ++QEE + ++ R +P Q+ M +T +
Sbjct: 296 AAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVIGRHRSP----CMQDRNHMPYTDAM 351
Query: 339 ITETARLANIVPGIFRKALR-EINFKGYTIPAGWAIMVCPPAVHLNPAKYQDPLVFNPSR 397
I E R N+VP +A+ +I F+ Y IP G ++ +V + ++ +P +F+P
Sbjct: 352 IHEVQRFINLVPNNIPRAVTCDIKFRNYLIPKGTTVVTSLTSVLHDSKEFPNPELFDPGH 411
Query: 398 WEGMEPSGATK---HFLAFGGGMRFCVGTEFAKVQMAVFLHCLVTKYRWRPI 446
+ ++ +G K HF+ F G R C G A++++ +FL ++ ++ +P+
Sbjct: 412 F--LDANGNFKKSDHFMPFSAGKRVCAGEGLARMELFLFLTTILQNFKLKPL 461
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.323 0.138 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,259,614
Number of Sequences: 164201
Number of extensions: 2474634
Number of successful extensions: 7785
Number of sequences better than 10.0: 697
Number of HSP's better than 10.0 without gapping: 372
Number of HSP's successfully gapped in prelim test: 325
Number of HSP's that attempted gapping in prelim test: 6033
Number of HSP's gapped (non-prelim): 919
length of query: 483
length of database: 59,974,054
effective HSP length: 114
effective length of query: 369
effective length of database: 41,255,140
effective search space: 15223146660
effective search space used: 15223146660
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 68 (30.8 bits)
Medicago: description of AC146573.1