BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146563.5 - phase: 0
(1436 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MRP2_RAT (Q63120) Canalicular multispecific organic anion transp... 738 0.0
MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4 (M... 731 0.0
MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1 (A... 711 0.0
YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c 672 0.0
YH85_SCHPO (Q9P5N0) Probable ATP-dependent permease C359.05 652 0.0
MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5 642 0.0
MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5 (M... 639 0.0
MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (A... 626 e-178
MRP6_HUMAN (O95255) Multidrug resistance-associated protein 6 (A... 601 e-171
BPT1_YEAST (P14772) Bile pigment transporter 1 590 e-167
YHD5_YEAST (P38735) Probable ATP-dependent permease YHL035C 585 e-166
ACC9_MOUSE (P70170) Sulfonylurea receptor 2 582 e-165
ACC8_HUMAN (Q09428) Sulfonylurea receptor 1 580 e-165
ACC9_RAT (Q63563) Sulfonylurea receptor 2 579 e-164
ACC9_RABIT (P82451) Sulfonylurea receptor 2 578 e-164
ACC9_HUMAN (O60706) Sulfonylurea receptor 2 577 e-163
MRP6_MOUSE (Q9R1S7) Multidrug resistance-associated protein 6 (A... 570 e-162
MRP6_RAT (O88269) Multidrug resistance-associated protein 6 (ATP... 569 e-161
L259_DROME (P91660) Probable multidrug resistance-associated pro... 567 e-161
YK83_YEAST (P36028) Probable ATP-dependent permease YKR103W/YKR104W 528 e-149
>MRP2_RAT (Q63120) Canalicular multispecific organic anion transporter
1 (ATP-binding cassette, sub-family C, member 2)
(Multidrug resistance-associated protein 2) (Canalicular
multidrug resistance protein)
Length = 1541
Score = 738 bits (1905), Expect = 0.0
Identities = 466/1352 (34%), Positives = 725/1352 (53%), Gaps = 126/1352 (9%)
Query: 184 ETKQTGLSNATLLSKLVFSWVNSLLSLGYSKPLALEDI----------------PTLVSE 227
++ QT A+ LS + FSW + + GY PL LED+ +++
Sbjct: 188 DSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTK 247
Query: 228 D--EANTAYQN---------------------------FVHEWESLGRKRSKNSTKNLVL 258
D +A A+Q + E + K +K+ K+ ++
Sbjct: 248 DLQKARQAFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLI 307
Query: 259 WSIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNLREGLSIVGFLILTK 318
S+ KT+ + L+ + V + P +L + + + + G +
Sbjct: 308 KSLFKTFHVVILKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICAILMFAVT 367
Query: 319 LVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSAGEIVNYIAVDAYRM 378
L++SF + +F + LGM +R+ +M ++Y+K L LS+ + +++ GE VN ++VD+ ++
Sbjct: 368 LIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKL 427
Query: 379 GEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLNVPFARILQNCQSQF 438
+ + + W+ ++Q+ LSI L+ +G L G+ +V+ +N A ++N Q Q
Sbjct: 428 MDATNYMQLVWSSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQN 487
Query: 439 MIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLSKSQILKASSSFLFW 498
M +D+RL+ +EIL+ +KI+K +WE F+ V+ +R KE L + L++ F+
Sbjct: 488 MKNKDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQ 547
Query: 499 MSPTIISSVVFLGCAISNSAP-LNAQTIFTVLATLKSMGDPVKMIPEALSILIQVKVSFD 557
++P ++S V F + +SA LNA+ FT + + P+ M+P S ++Q VS D
Sbjct: 548 ITPILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVD 607
Query: 558 RLNNFLLDEELHNDDNSEKHIKHCSSNVVEIQAGNFTWDLESVSPTLTDVNLEIKRGQKI 617
RL +L ++L D ++ + + + V+ +FTWD + + T+ DVNL+IK GQ +
Sbjct: 608 RLERYLGGDDL--DTSAIRRVSNFDK-AVKFSEASFTWDPD-LEATIQDVNLDIKPGQLV 663
Query: 618 AVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQSSWIQSGTVRDNILFGKPMNK 677
AV G VG+GKSSL+ A+LGE+ N+ G + + G+ AYV Q SWIQ+GT++DNILFG N+
Sbjct: 664 AVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNE 723
Query: 678 ARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIYLLDDP 737
+Y+ +KACAL D+ L GD+ EIG++GINLSGGQKQR+ LARA Y DADIY+LDDP
Sbjct: 724 KKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDP 783
Query: 738 FSAVDAHTAAILFNDCI--MTALREKTVILVTHQVEFLSKVVDRILDGK--VIQSGSYEN 793
SAVDAH +FN + L KT I VTH + FL +V + ++ GK +++ GSY +
Sbjct: 784 LSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRD 843
Query: 794 LLIAGTAFE---QLVNAHKDALTELNQDNKNQGSSEHDVLVNPQE--------------- 835
LL F + H E +N ++ + D L+ E
Sbjct: 844 LLDKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRREN 903
Query: 836 ------SHSVKEISTRGQ------------LTKEEEKEIG----------DVGWKPFWDY 867
S S + S RG+ + KE+EKE+ + G F Y
Sbjct: 904 SLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIY 963
Query: 868 ISY--SKGSLMLCFIVLAQSAFMALQTASSFWL-AIAIEIPKVTSAN--------LIGVY 916
+ Y + G + FI+L S+ WL A + + N IGV+
Sbjct: 964 LKYLQAVGWWSILFIILFYGLNNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVF 1023
Query: 917 SLISFTGVMFVYIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSD 969
+ + + I + NAS A T I +PM FFD+TP S D
Sbjct: 1024 GALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGD 1083
Query: 970 LSILDFDMPHAVHFALSVAIEV---LVIICIMASVTWQVLIVAVPAMVASIFIQHYYQAT 1026
+S +D +P + + + LV+IC+ V I+ +P + I +Q +Y AT
Sbjct: 1084 ISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPV---FAIIIIPLSILYISVQVFYVAT 1140
Query: 1027 ARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAM 1086
+R+L R++ TK+P+ + +ET G+ IRAF R + + K +D + F +
Sbjct: 1141 SRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSN 1200
Query: 1087 EWMVIRIEALQTLTVITAALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLS 1146
W+ IR+E + L V +ALLL++ ++ +VG LS A N+T + R S
Sbjct: 1201 RWLAIRLELVGNLVVFCSALLLVIY-RKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAE 1259
Query: 1147 NNIISVERIKQFIDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITC 1206
NI++VERI ++I++ E P + D RPP+ WP G I+ ++RYRP LVLKGITC
Sbjct: 1260 TNIVAVERISEYINVENEAPWV-TDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITC 1318
Query: 1207 TFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQ 1266
G +VGVVGRTG+GKS+L + LFR++E + G IIIDGI++ SIGL DLR +L+IIPQ
Sbjct: 1319 NIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQ 1378
Query: 1267 EPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQR 1326
+P LF GS+R NLDP Y+D E+W+ALE HL+ +S L L S V++ G N S+GQR
Sbjct: 1379 DPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQR 1438
Query: 1327 QLFCLGRVLLKRNKILVLDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSD 1386
QL CLGR +L+++KILVLDEATA++D TD+++Q IR+EF++CTVITIAHR+ T++DSD
Sbjct: 1439 QLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSD 1498
Query: 1387 MVMILSYGKLVEYDEPSKLMETNSSFSKLVAE 1418
+M+L GK+VEY P +L+ SF + E
Sbjct: 1499 KIMVLDNGKIVEYGSPEELLSNRGSFYLMAKE 1530
>MRP4_HUMAN (O15439) Multidrug resistance-associated protein 4
(MRP/cMOAT-related ABC transporter) (Multi-specific
organic anion tranporter-B) (MOAT-B)
Length = 1325
Score = 731 bits (1887), Expect = 0.0
Identities = 439/1281 (34%), Positives = 693/1281 (53%), Gaps = 58/1281 (4%)
Query: 184 ETKQTGLSNATLLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWES 243
E K L +A + S++ F W+N L +G+ + L +D+ +++ ED + + W+
Sbjct: 7 EVKPNPLQDANICSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDK 66
Query: 244 LGRKRSKNSTKNLVLWSIVKTYLQENILIAFYALLRTISVVVLPL----ILYAFVNYSSR 299
+ ++ K + +I+K Y + +++ + L+ + V+ P+ I+ F NY
Sbjct: 67 EVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPM 126
Query: 300 TEGNLREGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGK 359
L + L L+ + +F++ + GM++R A+ +Y K L+LS+
Sbjct: 127 DSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAM 186
Query: 360 IRHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVI 419
+ + G+IVN ++ D + + + H W LQ + A+L+ +GI L G+ L+I
Sbjct: 187 GKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLII 246
Query: 420 CGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKE 479
L F ++ + +S+ D R+R+ +E++ ++IIK+ +WE+ F NL+ +LR KE
Sbjct: 247 LLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKE 306
Query: 480 FVWLSKSQILKASSSFLFWMSPTIISSVVF-----LGCAISNSAPLNAQTIFTVLATLKS 534
+ +S L+ + F+ + II V F LG I+ S A T++ + +
Sbjct: 307 ISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVT 366
Query: 535 MGDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHIKHCSSNVVEIQAGNFT 594
+ P A+ + + VS R+ FLL +E+ + + +V +Q
Sbjct: 367 L-----FFPSAIERVSEAIVSIRRIQTFLLLDEI---SQRNRQLPSDGKKMVHVQDFTAF 418
Query: 595 WDLESVSPTLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYV 654
WD S +PTL ++ ++ G+ +AV GPVGAGKSSLL A+LGE+ G V+V G +AYV
Sbjct: 419 WDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYV 478
Query: 655 SQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGG 714
SQ W+ SGT+R NILFGK K RYE IKACAL +D+ L GDLT IG RG LSGG
Sbjct: 479 SQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGG 538
Query: 715 QKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALREKTVILVTHQVEFLS 774
QK R+ LARAVY DADIYLLDDP SAVDA + LF CI L EK ILVTHQ+++L
Sbjct: 539 QKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYL- 597
Query: 775 KVVDRIL---DGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQDN----KNQGSSEH 827
K +IL DGK++Q G+Y L +G F L+ + + +N+ SE
Sbjct: 598 KAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSES 657
Query: 828 DVLVNPQESHSVKEISTRGQLTK-------EEEKEIGDVGWKPFWDYISYSKGSLMLCFI 880
V S+K+ + Q T+ EE + G VG++ + +Y ++ F+
Sbjct: 658 SVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFL 717
Query: 881 VLAQSAFMALQTASSFWLAIAIEIPKVTSANL---------------IGVYSLISFTGVM 925
+L +A +WL+ + + + +G+YS ++ V+
Sbjct: 718 ILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVL 777
Query: 926 FVYIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMP 978
F RS L+ + +N+S + +I +P++FFD P S D+ LD +P
Sbjct: 778 FGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
Query: 979 HAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTK 1038
+ ++V+ ++ + +V + I VP + IF++ Y+ T+R++ R+ TT+
Sbjct: 838 LTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTR 897
Query: 1039 APVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQT 1098
+PV + + + G+ TIRA+ +R + + D + +F W +R++A+
Sbjct: 898 SPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICA 957
Query: 1099 LTVITAALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQF 1158
+ VI A ++L + G VGL+LSYA L G + R + + N +ISVER+ ++
Sbjct: 958 MFVIIVAFGSLILAKT-LDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEY 1016
Query: 1159 IDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVG 1218
D+ E P + RPP WP +G I + Y P PLVLK +T +VG+VG
Sbjct: 1017 TDLEKEAPWEYQ-KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVG 1075
Query: 1219 RTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTN 1278
RTG+GKS+LISALFRL EP G I ID I IGL DLR K+SIIPQEP LF G++R N
Sbjct: 1076 RTGAGKSSLISALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKN 1134
Query: 1279 LDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKR 1338
LDP +TD E+W AL++ LKETI LP +D+ +++ G N+S+GQRQL CL R +L++
Sbjct: 1135 LDPFKEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1339 NKILVLDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVE 1398
N+IL++DEATA++D TD ++Q+ IR++FA CTV+TIAHR+ T+IDSD +M+L G+L E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Query: 1399 YDEPSKLMETNSS-FSKLVAE 1418
YDEP L++ S F K+V +
Sbjct: 1255 YDEPYVLLQNKESLFYKMVQQ 1275
Score = 89.0 bits (219), Expect = 9e-17
Identities = 74/313 (23%), Positives = 146/313 (46%), Gaps = 21/313 (6%)
Query: 1121 VGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNRPPSPWPS 1180
V ++L A LT +F+ +S I+S+ RI+ F+ + I + NR P
Sbjct: 353 VAVTLYGAVRLT-VTLFFPSAIERVSEAIVSIRRIQTFLLLDE----ISQRNRQ-LPSDG 406
Query: 1181 KGRIEVQGLEIRY-RPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSR 1239
K + VQ + + + L+G++ T G + VVG G+GKS+L+SA+ + PS
Sbjct: 407 KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSH 466
Query: 1240 GDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHL 1299
G + + G +++ + Q+P +F G++R+N+ Y K ++ C L
Sbjct: 467 GLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACAL 513
Query: 1300 KETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDA-I 1358
K+ + L + + D G S GQ+ L R + + I +LD+ +++D+ +
Sbjct: 514 KKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHL 573
Query: 1359 LQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSSFSKLVAE 1418
+ I Q E I + H++ + + ++IL GK+V+ ++ +++ F L+ +
Sbjct: 574 FELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
Query: 1419 YWSSYKKSSIPNT 1431
++ +P T
Sbjct: 634 DNEESEQPPVPGT 646
>MRP1_MOUSE (O35379) Multidrug resistance-associated protein 1
(ATP-binding cassette, sub-family C, member 1)
Length = 1528
Score = 711 bits (1834), Expect = 0.0
Identities = 439/1324 (33%), Positives = 703/1324 (52%), Gaps = 106/1324 (8%)
Query: 191 SNATLLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSK 250
S+A+ LS++ F W+ ++ GY +PL D+ +L ED + V+ W+ K K
Sbjct: 211 SSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRK 270
Query: 251 NSTK-------------------------NLVLWS------------IVKTYLQENILIA 273
+ L++ S + KT+ ++
Sbjct: 271 QPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSF 330
Query: 274 FYALLRTISVVVLPLILYAFVNYSSRTEGNLREGLSIVGFLILTKLVESFSQRHWFFNSR 333
Y L + + P IL +N+ + E +G L ++ +++ + +F
Sbjct: 331 LYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICF 390
Query: 334 RLGMKMRSALMVAVYEKQLKLSSSGKIRHSAGEIVNYIAVDAYRMGEFPWWFHITWTCIL 393
GM++++A++ AVY K L ++++ + + GEIVN ++VDA R + + ++ W+ L
Sbjct: 391 VSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPL 450
Query: 394 QLVLSIAVLFGVVGIGALPGLVPLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEIL 453
Q++L++ L+ +G L G+ +++ LN A + Q M ++D R++ +EIL
Sbjct: 451 QVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEIL 510
Query: 454 NSMKIIKLQSWEEKFKNLVESLRDKEFVWLSKSQILKASSSFLFWMSPTIISSVVF-LGC 512
N +K++KL +WE F++ V S+R +E L KS L A +F + +P +++ F +
Sbjct: 511 NGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFV 570
Query: 513 AISNSAPLNAQTIFTVLATLKSMGDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHNDD 572
+ L+A+ F LA + P+ ++P +S ++Q VS RL FL EEL D
Sbjct: 571 TVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDS 630
Query: 573 NSEKHIKHCSSNVVEIQAGNFTWDLESVSPTLTDVNLEIKRGQKIAVCGPVGAGKSSLLY 632
+ IK N + ++ FTW PTL + I G +AV G VG GKSSLL
Sbjct: 631 IERRSIKSGEGNSITVKNATFTW-ARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
Query: 633 AILGEIPNIQGTVNVGGTLAYVSQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDED 692
A+L E+ ++G V + G++AYV Q +WIQ+ ++R+NILFG P+ + Y+ ++ACAL D
Sbjct: 690 ALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPD 749
Query: 693 INDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFND 752
+ L GD TEIG++G+NLSGGQKQR+ LARAVY+++DIYL DDP SAVDAH +F
Sbjct: 750 LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEK 809
Query: 753 CI--MTALREKTVILVTHQVEFLSKVVDRIL--DGKVIQSGSYENLLIAGTAFEQLVNAH 808
+ M L+ KT ILVTH + +L +V I+ GK+ + GSY+ LL AF + + +
Sbjct: 810 VVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTY 869
Query: 809 KDALTEL-NQDNKNQGSS------EHDVLVNP---------------------QESHSVK 840
+A +L ++D+ GS E+ +LV Q+ S+
Sbjct: 870 ANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIA 929
Query: 841 EISTRG------QLTKEEEKEIGDVGWKPFWDY-------ISYSKGSLMLCFIVLAQSAF 887
E+ G +L + ++ + G V +W+Y I++ L LC V A
Sbjct: 930 ELQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSA---- 985
Query: 888 MALQTASSFWLAIAIEIPKV---TSANL---IGVYSLISFTGVMFVYIRSYLMARLGLNA 941
AS++WL++ + P V T AN + VY + ++ S ++ G+ A
Sbjct: 986 ----LASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFA 1041
Query: 942 SIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSVAIEVLVI 994
S + SPM FF+ TP+ S +L +D +P + + V+
Sbjct: 1042 SRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGA 1101
Query: 995 ICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGVVT 1054
+ I+ T ++ P + F+Q +Y A++R+L R+ +++PV + ET LGV
Sbjct: 1102 VIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSV 1161
Query: 1055 IRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLPHG 1114
IRAF +R + VD + ++ S VA W+ +R+E + V+ AAL ++ H
Sbjct: 1162 IRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1221
Query: 1115 YVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNRP 1174
+S GLVGLS+SY+ +T + R S + NI++VER+K++ + E P +++ P
Sbjct: 1222 -LSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP 1280
Query: 1175 PSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRL 1234
PS WP GR+E + +RYR + LVLK I T G +VG+VGRTG+GKS+L LFR+
Sbjct: 1281 PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRI 1340
Query: 1235 VEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKAL 1294
E + G+IIIDG+NI IGL +LR K++IIPQ+P LF GS+R NLDP Y+D E+W AL
Sbjct: 1341 NESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMAL 1400
Query: 1295 EKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSA 1354
E HLK +S LP L+ ++ G N S+GQRQL CL R LL++ KILVLDEATA++D
Sbjct: 1401 ELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE 1460
Query: 1355 TDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSSFSK 1414
TD ++Q IR +F +CTV+TIAHR+ T++D V++L G++ E PS+L++ F
Sbjct: 1461 TDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYS 1520
Query: 1415 LVAE 1418
+ +
Sbjct: 1521 MAKD 1524
Score = 85.1 bits (209), Expect = 1e-15
Identities = 67/280 (23%), Positives = 129/280 (45%), Gaps = 18/280 (6%)
Query: 1143 STLSNNIISVERIKQFIDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLK 1202
S++ +S++R++ F+ P +E S I V+ + P L
Sbjct: 605 SSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSG--EGNSITVKNATFTWARGEPPTLN 662
Query: 1203 GITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLS 1262
GIT + EG+ V VVG+ G GKS+L+SAL ++ G + + G ++
Sbjct: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKG-------------SVA 709
Query: 1263 IIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWS 1322
+PQ+ + S+R N+ +N +E C L + LPS + + ++G N S
Sbjct: 710 YVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLS 769
Query: 1323 LGQRQLFCLGRVLLKRNKILVLDEATASIDSATDA-ILQRVIRQE--FAECTVITIAHRI 1379
GQ+Q L R + + I + D+ +++D+ I ++V+ T I + H I
Sbjct: 770 GGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGI 829
Query: 1380 PTVIDSDMVMILSYGKLVEYDEPSKLMETNSSFSKLVAEY 1419
+ D+++++S GK+ E +L++ + +F++ + Y
Sbjct: 830 SYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTY 869
>YAWB_SCHPO (Q10185) Probable ATP-dependent permease C3F10.11c
Length = 1478
Score = 672 bits (1735), Expect = 0.0
Identities = 440/1294 (34%), Positives = 692/1294 (53%), Gaps = 74/1294 (5%)
Query: 184 ETKQTGL-----SNATLLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFV 238
E ++TGL + A + S++ F W++ L+ GY L D +L + ++ F
Sbjct: 181 ELEETGLRPSRFTYANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFE 240
Query: 239 HEWESLGRKRSKNSTKNLVLWSIV-KTYLQENILIAFYALLRTISVVVLPLILYAFV--- 294
W S +K+ + L +W ++ + + ++I L++ + + P ++ V
Sbjct: 241 KNWISHAKKKKSS----LYMWGVLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFV 296
Query: 295 -NYSSRTEGNLREGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLK 353
+YSS + G S+ + LT +V++ + +F LGM+ RS L+ A+Y K L+
Sbjct: 297 SSYSSEHPQPPQVGFSLAIAMFLTNVVQTALLQQYFQLGMVLGMRWRSELITAIYRKSLR 356
Query: 354 LSSSGKIRHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPG 413
LSS+ + S G+IVNY++VD ++ + + + + Q+VL++ L+ +VG GAL G
Sbjct: 357 LSSAARQSRSVGDIVNYMSVDTQKVCDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSG 416
Query: 414 LVPLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVE 473
+ NV A I + Q++ M +D R + +EI+N+++ IKL +WE F +
Sbjct: 417 AFVTFLLFPCNVVIASIFKRFQNRQMKNKDARSQFMTEIINNIRSIKLYAWENIFLQKLL 476
Query: 474 SLRD-KEFVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAI--SNSAPLNAQTIFTVLA 530
LR+ +E L K I+ +F + +P ++S+ F + + L+ +F L+
Sbjct: 477 QLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSAATFGTFIVLYGKTRVLSVDIVFACLS 536
Query: 531 TLKSMGDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHI---KHCSSNVVE 587
+ P+ M+P +S +++ V+ R+ FL EL D N+ + K S +E
Sbjct: 537 LFNLLQFPLTMLPIVVSSVLEASVAISRIYGFLTAGEL--DSNAVQRYPANKEPSGVCLE 594
Query: 588 IQAGNFTWD---LESVSPTLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGT 644
I+ G F+W + PTL D++ +RG+ + G VG GKSSLL A LG + G+
Sbjct: 595 IKKGTFSWSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGS 654
Query: 645 VNVGGTLAYVSQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEI 704
V G++AY +Q WI + T+++NILFG ++ YE I+AC L D L+ GD TE+
Sbjct: 655 VFRCGSIAYAAQQPWILNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEV 714
Query: 705 GQRGINLSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTA--LREKT 762
G++GI+LSGGQK RI LARAVY+ +DIYLLDD SAVD H L + + + LR +
Sbjct: 715 GEKGISLSGGQKARISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRC 774
Query: 763 VILVTHQVEFLSK--VVDRILDGKVIQSGSYENLLIA-GTAFEQLVN--AHKDALTELNQ 817
VIL T+ + L + ++ + +GK+I+SGS+ L + + QL++ + KD +
Sbjct: 775 VILSTNSLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQLLSEFSKKDTASSTGA 834
Query: 818 D---NKNQGSSEHDVLVNPQESHSVKEIST------------RGQLTKE----------E 852
D +++Q V S S +S R +LT E E
Sbjct: 835 DTPLSRSQSVITSSTDVTSSASRSSDTVSNYPKATIKGTGRIRKRLTDEDNVKATGQAAE 894
Query: 853 EKEIGDVGWKPFWDYISYSKGSLMLCFIV-LAQSAFMALQTASSFWLAIAIEIPKVTSAN 911
+ E G V WK +W Y + SL L F+ L + + ++ WL E+ N
Sbjct: 895 KMERGKVKWKVYWTY--FKACSLFLIFLYFLFIIGGIGMNVGTNVWLKHWSEVNTQLGYN 952
Query: 912 -----LIGVYSLISFTGVMFVYIRSYLMARLGLNASIAYF-SSFTTAIFNSPMMFFDSTP 965
+G+Y+L + + S + S Y S A+ +PM FF++TP
Sbjct: 953 PKPYFYLGIYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTP 1012
Query: 966 A-------SSDLSILDFDMPHAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIF 1018
SSD+ +D + F +++ ++ ++ + +I+ VP +
Sbjct: 1013 TGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYRY 1072
Query: 1019 IQHYYQATARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATL 1078
Q YY T+REL R++ T++P+ E+ G+ TIRA++M D + VDT+ +
Sbjct: 1073 NQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRI 1132
Query: 1079 FFHSNVAMEWMVIRIEALQTLTVITAALLLILLP-HGYVSPGLVGLSLSYAFNLTGAQIF 1137
+F + W IR+EA+ L V ++A +L G + GLVGLSLSYA +T + F
Sbjct: 1133 WFLYFSSNRWQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVGLSLSYAVQITQSLTF 1192
Query: 1138 WTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNA 1197
R + NI+SVER+ ++I +P+E P+I+ D+RPP WPS G I+ +RYR N
Sbjct: 1193 VVRQSVDVETNIVSVERMLEYIGLPSEAPSIIPDHRPPEGWPSHGAIKFDHYSVRYRENL 1252
Query: 1198 PLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDL 1257
PLVL I+ ++G+VGRTG+GKSTL ALFRL+EP+ GDI +D INI SIGL DL
Sbjct: 1253 PLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDL 1312
Query: 1258 RMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDE 1317
R +L+IIPQE F+G+IR NLDP TD EIW ALE LK+ I L L S V++
Sbjct: 1313 RSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEG 1372
Query: 1318 GGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAILQRVIRQEFAECTVITIAH 1377
G N S GQRQL CL R LL ++L+LDEATA++D TDAI+QR IR+ F + T++TIAH
Sbjct: 1373 GANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAH 1432
Query: 1378 RIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSS 1411
RI TV+DS+ +++L +GK+VE+D KL+E +S
Sbjct: 1433 RINTVMDSNRILVLDHGKVVEFDSTKKLLENKAS 1466
>YH85_SCHPO (Q9P5N0) Probable ATP-dependent permease C359.05
Length = 1465
Score = 652 bits (1683), Expect = 0.0
Identities = 426/1294 (32%), Positives = 663/1294 (50%), Gaps = 92/1294 (7%)
Query: 193 ATLLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNS 252
A + SKL FSW++S + GY+ L D+ L ++ + F W SKN
Sbjct: 177 ANIFSKLSFSWISSFIKFGYTNYLKESDVWLLPPDERSGNLIIGFEDWWIY----HSKNK 232
Query: 253 TKNLVLWSIVK-TYLQENILIAFYALLRTISVVVLPLIL---------YAFVNYSSRTEG 302
++L LW ++ + + LI L++ + V P ++ Y N S + G
Sbjct: 233 RRSLFLWKLLFFNHWKLVALITITKLIQDVLAFVQPTLIQKTILFISSYTSPNPESPSRG 292
Query: 303 NLREGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRH 362
+ L +V + T L++ ++Q LGM+ ++ L+ ++Y K L LSSS +
Sbjct: 293 FIIAILVLVANFLQTLLLQQYNQLIML-----LGMRWKTELLASIYRKSLLLSSSARQNR 347
Query: 363 SAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGL 422
S G+I+NY+AVD ++ + P + I + Q+ L+++ L+ ++G A G+ VI
Sbjct: 348 SIGDIINYMAVDTQKISDLPIYLFIIVSGPFQIALALSNLYHLMGYSAFTGVAASVILFP 407
Query: 423 LNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRD-KEFV 481
N+ A + + QS M +D R + +EI+N+++ IKL +WE F + +R+ KE
Sbjct: 408 CNIIVANVYKKFQSILMKNKDSRSKLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELS 467
Query: 482 WLSKSQILKASSSFLFWMSPTIISSVVFLGCAI---SNSAPLNAQTIFTVLATLKSMGDP 538
L K + A F W+ TII + V G I + L A +F ++ + P
Sbjct: 468 MLKKIGFITAIGDFA-WIFTTIIVTTVAFGAFIIFHGKTQALTADIVFPAVSLFNLLQFP 526
Query: 539 VKMIPEALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHIKHCSSNV-VEIQAGNFTWDL 597
+ M+P +S L++ VS R+ FL+ +EL + + +EI++G F+W
Sbjct: 527 LAMLPTVISSLLEASVSVSRIYEFLIAQELDYNGVQRFPATEIPHEICLEIKSGTFSWSK 586
Query: 598 ES----VSPTLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAY 653
++ V+PTL +N K G+ + G VGAGKSSLL A +G + G+V G+LAY
Sbjct: 587 KTLKQQVTPTLRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGSLAY 646
Query: 654 VSQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSG 713
+Q WI T+R+NILFG + YE I AC L D + GD TE+GQ+G +LSG
Sbjct: 647 AAQQPWIFDATIRENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSG 706
Query: 714 GQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTA--LREKTVILVTHQVE 771
GQK RI LARA+Y+ ADIYLLDD S+VD H + L + LR V+L T+ +
Sbjct: 707 GQKSRISLARAIYSQADIYLLDDVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLN 766
Query: 772 FLSKV--VDRILDGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQDNKNQGSSEH-- 827
L + + + +GK+++ G+YE+L ++ + K L+E N + Q EH
Sbjct: 767 VLKEADSIYILSNGKIVEKGNYEHLFVSTNS------ELKQQLSEFNDEKDTQPLPEHTT 820
Query: 828 -----------DVLVNPQESHSVKEISTRG------------QLTKEEEK---------- 854
+ V E++S E Q E++K
Sbjct: 821 SYPSTQISLAPSIHVEGLETYSSSERKDSSNKYKSRKRNPIRQKVTEDDKGKCVAQTDEL 880
Query: 855 -EIGDVGWKPFWDYISYSKGSLMLCFIVLAQSAFMALQTASSFWLAIAIEIPKVTSANL- 912
+ G V W +W Y L+L + S M + A++ WL E +S+ L
Sbjct: 881 VQRGKVKWHVYWMYFKSCSIGLILLYFFFIISGIM-MNVATNVWLKHWSEENGKSSSELN 939
Query: 913 ------IGVYSLISFTGVMFVYIRSYLMARL-GLNASIAYFSSFTTAIFNSPMMFFDSTP 965
+G+Y F F+ S M L G+ + S I +PM FF++T
Sbjct: 940 PSPYFYLGIYLFFGFLSCAFISSSSLTMTVLCGIRSGRYLHDSMLKTILRAPMGFFETTS 999
Query: 966 A-------SSDLSILDFDMPHAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIF 1018
+ S+D+ +D + F +I+VL I+ ++ L++ VP ++
Sbjct: 1000 SGRILNRFSNDVYKVDEVVSLTFMFFFRNSIQVLFILGVICYSAPLSLLLIVPLFFLYLY 1059
Query: 1019 IQHYYQATARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATL 1078
+ YY T+REL R++ T++P+ E+ G+ TIRA+ M + ++ +DT+ +
Sbjct: 1060 NRAYYVRTSRELKRLDNVTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRV 1119
Query: 1079 FFHSNVAMEWMVIRIEALQTLTVITAALLLILLP-HGYVSPGLVGLSLSYAFNLTGAQIF 1137
+F + W IR+E + L + A IL G +PGLVG SLSYA +T F
Sbjct: 1120 WFMFFSSSRWQAIRVECIGDLIIFCTAFYGILSAIKGSPNPGLVGFSLSYAIQITQGLSF 1179
Query: 1138 WTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNA 1197
+ NN +SVERI ++I++ +E P I+ +NRPP WP+ G + +YR +
Sbjct: 1180 IVQQSVDAENNTVSVERILEYINVKSEAPEIIPENRPPCEWPTDGAVSFNHYSAKYREDL 1239
Query: 1198 PLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDL 1257
L I + ++G+VGRTG+GKSTL ALFR++EP+ G I ID +I GL DL
Sbjct: 1240 SFALNNINIEISPREKIGIVGRTGAGKSTLAMALFRIIEPTEGKIEIDNEDITKFGLYDL 1299
Query: 1258 RMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDE 1317
R +LSIIPQE +F+G+IR NLDP TD +IW+ LE LK IS+L L S V++
Sbjct: 1300 RSRLSIIPQESQIFEGNIRENLDPNHRLTDKKIWEVLEIASLKNCISQLEDGLYSRVAEG 1359
Query: 1318 GGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAILQRVIRQEFAECTVITIAH 1377
G N+S GQRQL CL RVLL +IL+LDEATAS+ + TDAI+Q+ IR+ F + T++T+AH
Sbjct: 1360 GANFSSGQRQLICLARVLLTSTRILLLDEATASVHAETDAIVQQTIRKRFKDRTILTVAH 1419
Query: 1378 RIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSS 1411
RI TV+DSD +++L +GK+VE+D KL+E S
Sbjct: 1420 RINTVMDSDRILVLDHGKVVEFDATKKLLENKDS 1453
>MRP5_RAT (Q9QYM0) Multidrug resistance-associated protein 5
Length = 1436
Score = 642 bits (1657), Expect = 0.0
Identities = 430/1332 (32%), Positives = 680/1332 (50%), Gaps = 117/1332 (8%)
Query: 187 QTGLSNATLLSKLVFSWVNSLLSLGYSK-PLALEDIPTLVSEDEANTAYQNFVHEW-ESL 244
Q + NA L S + FSW++ L + + K L +ED+ L + ++ + W E L
Sbjct: 98 QHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDVNCRRLERLWQEEL 157
Query: 245 GRKRSKNSTKNLVLWSIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNL 304
++ V+W +T L +I+ L S ++ + Y+ TE NL
Sbjct: 158 NEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAF--VVKHLLEYTQATESNL 215
Query: 305 REGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSA 364
+ L +V L+LT++V S+S + + R G+++R A++ ++K LKL + + S
Sbjct: 216 QYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAVLTMAFKKILKLKNIKE--KSL 273
Query: 365 GEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLN 424
GE++N + D RM E + + +L + ++G G ++
Sbjct: 274 GELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM 333
Query: 425 VPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLS 484
+ +R+ + + + A D+R++ +E+L +K IK+ +W + F V+ +R++E L
Sbjct: 334 MFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILE 393
Query: 485 KSQILKASSSFLFWMSP--TIISSVVFLGCAISNSAPLNAQTIFTVLAT-------LKSM 535
K+ + S ++P +I+SVV ++ L A FTV+ LK
Sbjct: 394 KAGYFQ---SITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT 450
Query: 536 GDPVKMIPEALSILIQVK-------------------VSFDRLNNFLLDEELHNDDNSE- 575
VK + EA + + K + + N L + H+ S
Sbjct: 451 PFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSP 510
Query: 576 -----------------------KHIKHCSSNVVEIQAGNFTWDL-ESVSP--------- 602
+H +H + V+ Q G+ D E SP
Sbjct: 511 KLTPKVKKDKRAPKGKKEKSRQLQHTEHQA--VLAEQKGHLLLDSDERPSPEEEEGKQIH 568
Query: 603 --------TLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYV 654
TL +++LEI+ G+ + +CG VG+GK+SL+ AILG++ ++G++ V GT AYV
Sbjct: 569 AGSMRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYV 628
Query: 655 SQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGG 714
+Q +WI + T+RDNILFGK ++ RY + + +C L D+ L + DLTEIG+RG NLSGG
Sbjct: 629 AQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGG 688
Query: 715 QKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALREKTVILVTHQVEFLS 774
Q+QRI LARA+Y+D IY+LDDP SA+DAH +FN I L+ KTV+ VTHQ+++L
Sbjct: 689 QRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLV 748
Query: 775 KVVDRIL--DGKVIQSGSYENLLIAGTAFEQLVN---AHKDALTELNQDNKNQGSSE-HD 828
+ I +G + + G++E L+ + + N + E+N + GS + D
Sbjct: 749 DCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEASGSQKSQD 808
Query: 829 VLVNPQESHSVKEI-STRGQLTKEEEKEIGDVGWKPFWDYISYSKGSLMLCFIVLAQSAF 887
P K + S GQL + EEK G V W +W YI + G L I++
Sbjct: 809 KGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLN 868
Query: 888 MALQTASSFWLAIAIEIPKVTSANLIG--------------------VYSLISFTGVMFV 927
+ S++WL+ I+ S G +Y+L ++
Sbjct: 869 VGSTAFSTWWLSYWIKQGSGNSTVFEGNRSSVSDSMRDNPFLQYYASIYALSMAVMLILK 928
Query: 928 YIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHA 980
IR + + L AS I SPM FFD+TP S D+ +D +P
Sbjct: 929 AIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQ 988
Query: 981 VHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAP 1040
+ I V + ++A V L+ P ++ + + REL R++ T++P
Sbjct: 989 AEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSVLHIVSRVLIRELKRLDNITQSP 1048
Query: 1041 VMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLT 1100
++ + G+ TI A+N + Y +L+D + FF AM W+ +R++ + ++
Sbjct: 1049 FLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLI-SIA 1107
Query: 1101 VITAALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFID 1160
+IT L+I+L HG + GL++SYA LTG F R S SVERI +I
Sbjct: 1108 LITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIK 1167
Query: 1161 -IPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGR 1219
+ E PA +++ PP WP +G I + E+RYR N PLVLK ++ T ++G+VGR
Sbjct: 1168 TLSLEAPARIKNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGR 1227
Query: 1220 TGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNL 1279
TGSGKS+L ALFRLVE S G I IDG+ I IGL DLR KL+IIPQEP LF G++R+NL
Sbjct: 1228 TGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEPVLFSGTVRSNL 1287
Query: 1280 DPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRN 1339
DP YT+ +IW ALE+ H+KE I++LP L+S V + G N+S+G+RQL C+ R LL+
Sbjct: 1288 DPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHC 1347
Query: 1340 KILVLDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEY 1399
KIL+LDEATA++D+ TD ++Q IR+ FA+CT++TIAHR+ TV+ SD +M+L+ G++VE+
Sbjct: 1348 KILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEF 1407
Query: 1400 DEPSKLMETNSS 1411
D PS L+ +SS
Sbjct: 1408 DTPSVLLSNDSS 1419
Score = 85.5 bits (210), Expect = 1e-15
Identities = 62/250 (24%), Positives = 115/250 (45%), Gaps = 21/250 (8%)
Query: 1168 IMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTL 1227
+++ + PSP +G+ ++ +R + L I EG VG+ G GSGK++L
Sbjct: 550 LLDSDERPSPEEEEGK-QIHAGSMRLQRT----LYNIDLEIEEGKLVGICGSVGSGKTSL 604
Query: 1228 ISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTD 1287
ISA+ + G I + G + + Q+ + ++R N+ G D
Sbjct: 605 ISAILGQMTLLEGSIAVSGT-------------FAYVAQQAWILNATLRDNI-LFGKEFD 650
Query: 1288 NEIWKA-LEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDE 1346
E + + L C L+ ++ LP+ + + + G N S GQRQ L R L I +LD+
Sbjct: 651 EERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
Query: 1347 ATASIDSAT-DAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKL 1405
+++D+ + I IR+ TV+ + H++ ++D D V+ + G + E +L
Sbjct: 711 PLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770
Query: 1406 METNSSFSKL 1415
M N ++ +
Sbjct: 771 MNLNGDYATI 780
>MRP5_HUMAN (O15440) Multidrug resistance-associated protein 5
(Multi-specific organic anion tranporter-C) (MOAT-C)
(pABC11) (SMRP)
Length = 1437
Score = 639 bits (1648), Expect = 0.0
Identities = 425/1328 (32%), Positives = 687/1328 (51%), Gaps = 108/1328 (8%)
Query: 187 QTGLSNATLLSKLVFSWVNSLLSLGYSK-PLALEDIPTLVSEDEANTAYQNFVHEW-ESL 244
Q + NA L S + FSW++SL + + K L++ED+ +L + ++ + W E L
Sbjct: 98 QHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEEL 157
Query: 245 GRKRSKNSTKNLVLWSIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNL 304
++ V+W +T L +I+ L S ++ + Y+ TE NL
Sbjct: 158 NEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAF--MVKHLLEYTQATESNL 215
Query: 305 REGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSA 364
+ L +V L+LT++V S+S + + R G+++R A++ ++K LKL + + S
Sbjct: 216 QYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKE--KSL 273
Query: 365 GEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLN 424
GE++N + D RM E + + +L + ++G G ++
Sbjct: 274 GELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM 333
Query: 425 VPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLS 484
+ +R+ + + + A DER++ +E+L +K IK+ +W + F V+ +R++E L
Sbjct: 334 MFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILE 393
Query: 485 KSQILKASSSFLFWMSPTIISSVVF-----LGCAISNSAPLNAQTIFTVLA--------T 531
K+ ++ + + + I S V F LG ++ + T+F + +
Sbjct: 394 KAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFS 453
Query: 532 LKSMGDP------------------VKMIPEALSILIQVK---VSFDRLNNFL-----LD 565
+KS+ + +K P + I I++K +++D ++ + L
Sbjct: 454 VKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLT 513
Query: 566 EELHNDDNSEKHIKHCSSN--------VVEIQAGNFTWDL-ESVSP-------------- 602
++ D + + K V+ Q G+ D E SP
Sbjct: 514 PKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLR 573
Query: 603 ---TLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQSSW 659
TL ++LEI+ G+ + +CG VG+GK+SL+ AILG++ ++G++ + GT AYV+Q +W
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAW 633
Query: 660 IQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRI 719
I + T+RDNILFGK ++ RY + + +C L D+ L DLTEIG+RG NLSGGQ+QRI
Sbjct: 634 ILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRI 693
Query: 720 QLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALREKTVILVTHQVEFLSKVVDR 779
LARA+Y+D IY+LDDP SA+DAH +FN I L+ KTV+ VTHQ+++L +
Sbjct: 694 SLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEV 753
Query: 780 IL--DGKVIQSGSYENLLIAGTAFEQLVN---AHKDALTELNQDNKNQGSSEHDVLVNPQ 834
I +G + + G++E L+ + + N + E+N + GS + P+
Sbjct: 754 IFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPK 813
Query: 835 ESHSVKEISTR---GQLTKEEEKEIGDVGWKPFWDYISYSKGSLMLCFIVLAQSAFMALQ 891
KE + + GQL + EEK G V W + YI + G L I+ +
Sbjct: 814 TGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGST 873
Query: 892 TASSFWLAIAIEIPK----VTSAN----------------LIGVYSLISFTGVMFVYIRS 931
S++WL+ I+ VT N +Y+L ++ IR
Sbjct: 874 AFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRG 933
Query: 932 YLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFA 984
+ + L AS I SPM FFD+TP S D+ +D +P
Sbjct: 934 VVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMF 993
Query: 985 LSVAIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNF 1044
+ I V + ++A V L+ P ++ + + REL R++ T++P ++
Sbjct: 994 IQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSH 1053
Query: 1045 AAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITA 1104
+ G+ TI A+N + Y +L+D + FF AM W+ +R++ + ++ +IT
Sbjct: 1054 ITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLI-SIALITT 1112
Query: 1105 ALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFID-IPA 1163
L+I+L HG + P GL++SYA LTG F R S SVERI +I +
Sbjct: 1113 TGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSL 1172
Query: 1164 EPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSG 1223
E PA +++ P WP +G + + E+RYR N PLVLK ++ T ++G+VGRTGSG
Sbjct: 1173 EAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSG 1232
Query: 1224 KSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLG 1283
KS+L ALFRLVE S G I IDG+ I IGL DLR KLSIIPQEP LF G++R+NLDP
Sbjct: 1233 KSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFN 1292
Query: 1284 LYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILV 1343
YT+++IW ALE+ H+KE I++LP L+S V + G N+S+G+RQL C+ R LL+ KIL+
Sbjct: 1293 QYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILI 1352
Query: 1344 LDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPS 1403
LDEATA++D+ TD ++Q IR+ FA+CT++TIAHR+ TV+ SD +M+L+ G++VE+D PS
Sbjct: 1353 LDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPS 1412
Query: 1404 KLMETNSS 1411
L+ +SS
Sbjct: 1413 VLLSNDSS 1420
Score = 87.8 bits (216), Expect = 2e-16
Identities = 63/250 (25%), Positives = 112/250 (44%), Gaps = 21/250 (8%)
Query: 1168 IMEDNRPPSPWPSKGR-IEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKST 1226
+++ + PSP +G+ I + L ++ L I EG VG+ G GSGK++
Sbjct: 550 LLDSDERPSPEEEEGKHIHLGHLRLQR------TLHSIDLEIQEGKLVGICGSVGSGKTS 603
Query: 1227 LISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYT 1286
LISA+ + G I I G + + Q+ + ++R N+ Y
Sbjct: 604 LISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKEYD 650
Query: 1287 DNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDE 1346
+ L C L+ ++ LPS + + + G N S GQRQ L R L I +LD+
Sbjct: 651 EERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
Query: 1347 ATASIDSAT-DAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKL 1405
+++D+ + I IR+ TV+ + H++ ++D D V+ + G + E +L
Sbjct: 711 PLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770
Query: 1406 METNSSFSKL 1415
M N ++ +
Sbjct: 771 MNLNGDYATI 780
>MRP5_MOUSE (Q9R1X5) Multidrug resistance-associated protein 5 (ABC
transporter MOAT-C) (SMRP)
Length = 1436
Score = 626 bits (1615), Expect = e-178
Identities = 425/1330 (31%), Positives = 684/1330 (50%), Gaps = 113/1330 (8%)
Query: 187 QTGLSNATLLSKLVFSWVNSLLSLGYSK-PLALEDIPTLVSEDEANTAYQNFVHEW-ESL 244
Q + NA L S + FSW++ L + + K L +ED+ L + ++ + W E L
Sbjct: 98 QHPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKYESSDVNCRRLERLWQEEL 157
Query: 245 GRKRSKNSTKNLVLWSIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNL 304
++ V+W +T L +I+ L S ++ + Y+ TE NL
Sbjct: 158 NEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAF--MVKHLLEYTQATESNL 215
Query: 305 REGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSA 364
+ L +V L+LT++V S+S + + R G+++R A++ ++K LKL + + S
Sbjct: 216 QCSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKE--KSL 273
Query: 365 GEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLN 424
GE++N + D RM E + + +L + ++G G ++
Sbjct: 274 GELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM 333
Query: 425 VPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLS 484
+ +R+ + + + A D+R++ +E+L +K IK+ +W + F V+ +R++E L
Sbjct: 334 MFVSRLTAYFRRKRVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILE 393
Query: 485 KSQILKASSSFLFWMSP--TIISSVVFLGCAISNSAPLNAQTIFTVLA------------ 530
K+ + S ++P +I+SVV ++ L A FTV+
Sbjct: 394 KAGYFQ---SITVGVAPIVVVIASVVTFSVHMTLGFHLTAAQAFTVVTVFNSMTFALKVT 450
Query: 531 --TLKSMGDP------------------VKMIPEALSILIQVK---VSFDRLNNFL---- 563
++KS+ + +K P + I I++K +++D ++ +
Sbjct: 451 PFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSP 510
Query: 564 -LDEELHNDDNSEKHIKHCSSN--------VVEIQAGNFTWDL-ESVSP----------- 602
L ++ D + + K S V+ Q G+ D E SP
Sbjct: 511 KLTPKMKKDKRATRGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHTG 570
Query: 603 ------TLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQ 656
TL +++LEI+ G+ + +CG VG+GK+SL+ AILG++ ++G++ V GT AYV+Q
Sbjct: 571 SLRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQ 630
Query: 657 SSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQK 716
+WI + T+RDNILFGK ++ RY + + +C L D+ L + DLTEIG+RG NLSGGQ+
Sbjct: 631 QAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQR 690
Query: 717 QRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALREKTVILVTHQVEFLSKV 776
QRI LARA+Y+D IY+LDDP SA+DAH +FN I L+ KTV+ VTHQ+++L
Sbjct: 691 QRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDC 750
Query: 777 VDRIL--DGKVIQSGSYENLLIAGTAFEQLVN---AHKDALTELNQDNKNQGSSE-HDVL 830
+ I +G + + G++E L+ + + N + E+N + GS + D
Sbjct: 751 DEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEATGSQKSQDKG 810
Query: 831 VNPQESHSVKEI-STRGQLTKEEEKEIGDVGWKPFWDYISYSKGSLMLCFIVLAQSAFMA 889
P K + S GQL + EEK G V W +W YI + G L I++ +
Sbjct: 811 PKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVG 870
Query: 890 LQTASSFWLAIAIEIPKVTSANLIG--------------------VYSLISFTGVMFVYI 929
S++WL+ I+ S G +Y+L ++ I
Sbjct: 871 STAFSTWWLSYWIKQGSGNSTVYQGNRSFVSDSMKDNPFMQYYASIYALSMAVMLILKAI 930
Query: 930 RSYLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVH 982
R + + L AS I SPM FFD+TP S D+ +D +P
Sbjct: 931 RGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 990
Query: 983 FALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVM 1042
+ I V + ++A V L+ P ++ + + REL R++ T++P +
Sbjct: 991 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSLLHIVSRVLIRELKRLDNITQSPFL 1050
Query: 1043 NFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVI 1102
+ + G+ TI A+N + Y +L+D + FF AM W+ +R++ + ++ +I
Sbjct: 1051 SHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLPVRLDII-SIALI 1109
Query: 1103 TAALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFID-I 1161
T+ L+I+ GL++SYA L G F R S SVERI +I +
Sbjct: 1110 TSTGLMIVSGMARSLSAYAGLAISYAVQLIGLFQFTVRLASETEARFTSVERINHYIKTL 1169
Query: 1162 PAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTG 1221
E PA +++ PP WP +G + + E+RYR N PLVLK ++ T ++G+VGRTG
Sbjct: 1170 SLEAPARIKNKAPPHDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTG 1229
Query: 1222 SGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDP 1281
SGKS+L ALFRLVE S G I IDGI I IGL DLR KL+IIPQEP LF G++R+NLDP
Sbjct: 1230 SGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRSNLDP 1289
Query: 1282 LGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKI 1341
YT+++IW ALE+ H+KE I++LP L+S V + G N+S+G+RQL C+ R LL+ KI
Sbjct: 1290 FNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKI 1349
Query: 1342 LVLDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDE 1401
L+LDEATA++D+ TD ++Q IR+ FA+CT++TIAHR+ TV+ SD +M+L+ G++VE+D
Sbjct: 1350 LILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDT 1409
Query: 1402 PSKLMETNSS 1411
PS L+ +SS
Sbjct: 1410 PSVLLSNDSS 1419
Score = 85.1 bits (209), Expect = 1e-15
Identities = 62/251 (24%), Positives = 114/251 (44%), Gaps = 23/251 (9%)
Query: 1168 IMEDNRPPSPWPSKGR-IEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKST 1226
+++ + PSP +G+ I L ++ L I EG VG+ G GSGK++
Sbjct: 550 LLDSDERPSPEEEEGKQIHTGSLRLQR------TLYNIDLEIEEGKLVGICGSVGSGKTS 603
Query: 1227 LISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYT 1286
L+SA+ + G I + G + + Q+ + ++R N+ G
Sbjct: 604 LVSAILGQMTLLEGSIAVSGT-------------FAYVAQQAWILNATLRDNI-LFGKEF 649
Query: 1287 DNEIWKA-LEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLD 1345
D E + + L C L+ ++ LP+ + + + G N S GQRQ L R L I +LD
Sbjct: 650 DEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILD 709
Query: 1346 EATASIDSAT-DAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSK 1404
+ +++D+ + I IR+ TV+ + H++ ++D D V+ + G + E +
Sbjct: 710 DPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEE 769
Query: 1405 LMETNSSFSKL 1415
LM N ++ +
Sbjct: 770 LMNLNGDYATI 780
>MRP6_HUMAN (O95255) Multidrug resistance-associated protein 6
(ATP-binding cassette, sub-family C, member 6)
(Anthracycline resistance-associated protein)
(Multi-specific organic anion tranporter-E) (MOAT-E)
Length = 1503
Score = 601 bits (1549), Expect = e-171
Identities = 433/1445 (29%), Positives = 709/1445 (48%), Gaps = 99/1445 (6%)
Query: 51 FSLVSICCAFTSIAYFATGFWNLLDKTGNSKDLSWLACIIRGIIWISITVSLLV-----Q 105
F+L+ +C + ++A W + T + + +I +W++ T+S V +
Sbjct: 77 FALIVLCTSSVAVA-----LWKIQQGTPEAPEF-----LIHPTVWLT-TMSFAVFLIHTE 125
Query: 106 QVKWIQ---ILNSVWWASSCVLVSALNIDILFKGHAIQTFDITIWLVH-CLLLLCSYKNL 161
+ K +Q +L W C ++ A N G Q+ + + CL L+ + L
Sbjct: 126 RKKGVQSSGVLFGYWLL--CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVL 183
Query: 162 GYLGTHSVPECLYSEPLLAQKCETKQTGLSNATLLSKLVFSWVNSLLSLGYSKPLALEDI 221
L P +P + C +TG A SK F WV+ L+ GY +PL +D+
Sbjct: 184 SCLADQ--PPFFPEDPQQSNPCP--ETG---AAFPSKATFWWVSGLVWRGYRRPLRPKDL 236
Query: 222 PTLVSEDEANTAYQNFVHEW---ESLGRKRSKNSTKNLVLWSIVKT-----YLQEN---- 269
+L E+ + EW S R+ +K S +K +L++
Sbjct: 237 WSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQW 296
Query: 270 ------ILIAFYA--LLRTISVVV-------LPLILYAFVNYSSRTEGNLREGLSIVGFL 314
I F++ LL T+S+++ +P +L F+ + + +G + +
Sbjct: 297 RPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLM 356
Query: 315 ILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSAGEIVNYIAVD 374
L+ +++ ++ + + L M++RSA+ VY K L LSS + + G++VN ++VD
Sbjct: 357 FLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVD 416
Query: 375 AYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLNVPFARILQNC 434
R+ E + + W ++ +V+ L+ ++G AL + + LN ++ +
Sbjct: 417 VQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHH 476
Query: 435 QSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLSKSQILKASSS 494
Q + M +D R R TS IL + K IK WE F + V +R +E L S +L + S
Sbjct: 477 QEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL 536
Query: 495 FLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSMGDPVKMIPEALSILIQVKV 554
F +S +++ VVF + +NA+ F L L + +P ++ L+Q +V
Sbjct: 537 VSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARV 596
Query: 555 SFDRLNNFLLDEELHNDD-NSEKHIKHCSSNVVEIQAGNFTWDLESVSPTLTDVNLEIKR 613
SFDRL FL EE+ +S + + I + F W ES P L +NL + +
Sbjct: 597 SFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQES-PPCLHRINLTVPQ 655
Query: 614 GQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQSSWIQSGTVRDNILFGK 673
G +AV GPVGAGKSSLL A+LGE+ ++G V++ G +AYV Q +W+Q+ +V +N+ FG+
Sbjct: 656 GCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQ 715
Query: 674 PMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIYL 733
++ E ++ACAL D++ G T IG++G+NLSGGQKQR+ LARAVY A +YL
Sbjct: 716 ELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYL 775
Query: 734 LDDPFSAVDAHTAAILFNDCIMTA--LREKTVILVTHQVEFLSKV--VDRILDGKVIQSG 789
LDDP +A+DAH +FN I L+ T ILVTH + L + + + +G + + G
Sbjct: 776 LDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMG 835
Query: 790 SYENLLIAGTAFEQLVNAHK------DALTELNQDNKNQGSSEHDVLVNPQESHSVKEIS 843
SY+ LL A L++ + + TE K+ + + S+K +
Sbjct: 836 SYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVP 895
Query: 844 TRGQLTKEEEKEI-----GDVGWKPFWDYISYS--KGSLMLCFI--------VLAQSAFM 888
+ + T E + E+ GW D I Y K ++ L ++ + A F+
Sbjct: 896 EKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFL 955
Query: 889 ALQTAS---SFWLAIAIEIPKV----TSANLIG-VYSLISFTGVMFVYIRSYLMARLGLN 940
Q AS +WL++ + P V T A L G ++ L+ + ++ + G
Sbjct: 956 CQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGAR 1015
Query: 941 ASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSVAIEVLV 993
AS F + SP+ FF+ TP S + +D D+P + L A +L
Sbjct: 1016 ASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLE 1075
Query: 994 IICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGVV 1053
+ ++A T + +P + Q Y ++ +L R+ + + V + AET G
Sbjct: 1076 VSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGST 1135
Query: 1054 TIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLPH 1113
+RAF + VD + F VA W+ +E L V AA +L
Sbjct: 1136 VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVL-SK 1194
Query: 1114 GYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNR 1173
++S GLVG S+S A +T + R ++ L N+I+SVER++ + P E P +
Sbjct: 1195 AHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA 1254
Query: 1174 PPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFR 1233
PWP G+IE + +RYRP PL ++G++ + G +VG+VGRTG+GKS+L S L R
Sbjct: 1255 AQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLR 1314
Query: 1234 LVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKA 1293
L E + G I IDG+ I +GL LR ++SIIPQ+P LF GS+R NLD L ++D IW A
Sbjct: 1315 LQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAA 1374
Query: 1294 LEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDS 1353
LE LK ++ LP L +D G + S+GQ+QL CL R LL++ +IL+LDEATA++D
Sbjct: 1375 LETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP 1434
Query: 1354 ATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSSFS 1413
T+ +Q ++ FA+CTV+ IAHR+ +V+D V+++ G++ E P++L+ F
Sbjct: 1435 GTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494
Query: 1414 KLVAE 1418
+L E
Sbjct: 1495 RLAQE 1499
>BPT1_YEAST (P14772) Bile pigment transporter 1
Length = 1559
Score = 590 bits (1520), Expect = e-167
Identities = 410/1338 (30%), Positives = 671/1338 (49%), Gaps = 133/1338 (9%)
Query: 195 LLSKLVFSWVNSLLSLGYSKPLALE--DIPTLVSEDEANTAYQNFVHEWESLGRKRSKNS 252
+LS + F W+N L+ Y + +P + + + F WE L + ++NS
Sbjct: 221 VLSYITFIWMNKLIVETYRNKKIKDPNQLPLPPVDLNIKSISKEFKANWE-LEKWLNRNS 279
Query: 253 TKNLVLWSIVKTYLQENILIAF-YALLRTISVVVLPLILYAFV---NYSSRTEGNLREGL 308
LW + I +A Y + VV P L F+ N + ++ G+
Sbjct: 280 -----LWRAIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGLNPETSSKYPPLNGV 334
Query: 309 SIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSAGEIV 368
I L + +V F ++ G+ +R +L VY+K L+L+ + + S G+I+
Sbjct: 335 FIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDIL 394
Query: 369 NYIAVDAYRMGEFPWWFHITWTCI---LQLVLSIAVLFGVVGIGALPGLVPLVICGLLNV 425
N ++VD R+ F F T I +Q+++ + L+ ++G + GLV + I +N
Sbjct: 395 NLMSVDVLRIQRF---FENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINA 451
Query: 426 PFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLR-DKEFVWLS 484
+R ++ M +D R+++ +E+LN++K IKL +WEE + +R D E
Sbjct: 452 FLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFR 511
Query: 485 KSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSMGDPVKMIPE 544
K I+ F + P +++ F ++ + +PL+ +F L+ + + +P
Sbjct: 512 KIGIVSNLIYFAWNCVPLMVTCSTFGLFSLFSDSPLSPAIVFPSLSLFNILNSAIYSVPS 571
Query: 545 ALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHIKHCSSN----VVEIQAGNFTW----- 595
++ +I+ VS +RL +FLL +E+ DD+ + I + +E+ F W
Sbjct: 572 MINTIIETSVSMERLKSFLLSDEI--DDSFIERIDPSADERALPAIEMNNITFLWKSKEV 629
Query: 596 ------------DLESV--SPTLTDVNL---EIKRGQKIAVCGPVGAGKSSLLYAILGEI 638
D ES+ S + N+ E KRG + V G VGAGKS+ L AILG++
Sbjct: 630 LTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQL 689
Query: 639 PNIQGT--------VNVGGTLAYVSQSSWIQSGTVRDNILFGKPMNKARYENAIKACALD 690
P + G+ + ++AY SQ SWI + +VR+NILFG ++ Y+ IKAC L
Sbjct: 690 PCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLL 749
Query: 691 EDINDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILF 750
D+ L GD T +G++GI+LSGGQK R+ LARAVY+ ADIYLLDD SAVDA + +
Sbjct: 750 PDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNII 809
Query: 751 NDCIM---TALREKTVILVTHQVEFL--SKVVDRILDGKVIQSGSYENLLIAGTAFEQLV 805
++ L+ KT+IL T+ V L S+++ + +G++++ G+YE+++ +L
Sbjct: 810 EYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLK 869
Query: 806 NAHKDALTELNQDNKNQGSSEH--------------------DVLVNPQESHSVKEISTR 845
++ + ++ N++ +EH D +V E +K S R
Sbjct: 870 KLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRR 929
Query: 846 GQLT--------------------KEEEKEIGDVGWKPFWDYISYSKGSLMLCFIVLAQS 885
L K E+ E+G V K + YI + G L + L
Sbjct: 930 ASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIK-ACGVLGVVLFFLFMI 988
Query: 886 AFMALQTASSFWLAIAIEIPKVTSAN-----LIGVYSLISFTGVMFVYIRSYLMARL-GL 939
A +FWL E + +N +GVYSLI F +RS +M +
Sbjct: 989 LTRVFDLAENFWLKYWSESNEKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSI 1048
Query: 940 NASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSVAIEVL 992
S S ++ SPM FF++TP SSD+ +D ++ + F + L
Sbjct: 1049 RGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYL 1108
Query: 993 VIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGV 1052
V + ++ L+ + +V I+ Q +Y +REL R+ + +P+M+ +E+ G
Sbjct: 1109 VTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGY 1168
Query: 1053 VTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLP 1112
I A++ +R + + + + F+ W+ +R++ + V+ A+L +
Sbjct: 1169 SIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATM 1228
Query: 1113 HG--YVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIME 1170
+ +S G+VGL +SY+ +TG+ + R T+ NI+SVERI ++ ++P E +I
Sbjct: 1229 NTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINP 1288
Query: 1171 DNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISA 1230
+ RP WPSKG IE + +YR N VL I +VG+VGRTG+GKSTL A
Sbjct: 1289 EKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLA 1348
Query: 1231 LFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEI 1290
LFR++EP+ G IIIDGI+I IGL DLR L+IIPQ+ F+G+++TNLDP Y+++E+
Sbjct: 1349 LFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDEL 1408
Query: 1291 WKALEKCHLKETISRL-----------------PSLLDSSVSDEGGNWSLGQRQLFCLGR 1333
+A+E+ HLK + ++ +LD +++ G N S+GQRQL CL R
Sbjct: 1409 KRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLAR 1468
Query: 1334 VLLKRNKILVLDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSY 1393
LL R+KILVLDEATAS+D TD I+Q IR+EF + T++TIAHRI TV+DSD +++L
Sbjct: 1469 ALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQ 1528
Query: 1394 GKLVEYDEPSKLMETNSS 1411
G + E+D PSKL+ +S
Sbjct: 1529 GSVREFDSPSKLLSDKTS 1546
Score = 62.0 bits (149), Expect = 1e-08
Identities = 85/340 (25%), Positives = 144/340 (42%), Gaps = 40/340 (11%)
Query: 1107 LLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWT-RWFSTLSNNIISVERIKQF------- 1158
L L +SP +V SLS FN+ + I+ +T+ +S+ER+K F
Sbjct: 538 LFSLFSDSPLSPAIVFPSLSL-FNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEID 596
Query: 1159 ------IDIPAEPPAI--MEDNRPPSPWPSKGRIEVQGLEIRYRPN-------APLVLKG 1203
ID A+ A+ +E N W SK + R + + + LK
Sbjct: 597 DSFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKN 656
Query: 1204 IT-CTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRG--DIIIDGINICSIGLKDLRMK 1260
I G V VVGR G+GKST + A+ + G D I + I S
Sbjct: 657 IDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRS-------SS 709
Query: 1261 LSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWK-ALEKCHLKETISRLPSLLDSSVSDEGG 1319
++ QE + S+R N+ G D + + ++ C L + LP ++ V ++G
Sbjct: 710 VAYCSQESWIMNASVRENI-LFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGI 768
Query: 1320 NWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDA-ILQRVIRQEFA---ECTVITI 1375
+ S GQ+ L R + R I +LD+ +++D+ I++ V+ + A T+I
Sbjct: 769 SLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILT 828
Query: 1376 AHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSSFSKL 1415
+ + + S M+ L G++VE +M ++ SKL
Sbjct: 829 TNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKL 868
>YHD5_YEAST (P38735) Probable ATP-dependent permease YHL035C
Length = 1592
Score = 585 bits (1508), Expect = e-166
Identities = 402/1309 (30%), Positives = 668/1309 (50%), Gaps = 113/1309 (8%)
Query: 193 ATLLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNS 252
+++LS + +SW+ + + + L+DI L ED Y F+ + + K N
Sbjct: 272 SSILSCITWSWITNFIWEAQKNTIKLKDIWGLSMED-----YSIFILKGFTRRNKHINNL 326
Query: 253 TKNLVLWSIVKTYLQENILIAFYALLRTISVVVLPLILYA----FVNYSSRTEGNLREGL 308
T L L+ KTYL LI +L V +LP IL V+ +R+ +
Sbjct: 327 T--LALFESFKTYL----LIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNRSSSCMNLAW 380
Query: 309 SIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKL---------SSSGK 359
+ + + +L + F S ++ +++R+ L+ +Y K L+ S S
Sbjct: 381 LYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSDS 440
Query: 360 IRHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVI 419
I + G I+N I++D++++ E + ++T ++ +++ + +LF +G+ A G+ +++
Sbjct: 441 ISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILV 500
Query: 420 CGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKE 479
LN A +L Q Q + D+R+ +E L +++I+K +WE N ++S+R KE
Sbjct: 501 MFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKE 560
Query: 480 FVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSMGDPV 539
L K ++ + +SFL++++PT+++ V F C LNA FT L+ + P+
Sbjct: 561 LRSLLKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAPLAFTTLSLFTLLKTPL 620
Query: 540 KMIPEALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHIKHCSS---NVVEIQAGNFTW- 595
+ LS + Q KVS R+++FL D++EK+ + S N +E + TW
Sbjct: 621 DQLSNMLSFINQSKVSLKRISDFL------RMDDTEKYNQLTISPDKNKIEFKNATLTWN 674
Query: 596 --DLESVSPTLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGG---- 649
D + + L +N++ + G+ + G G+GKS+LL +LGE+ I G++ V
Sbjct: 675 ENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPK 734
Query: 650 ------------TLAYVSQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLS 697
+ AY SQS+W+ + TV++NI+F N+ RY I AC L D+ L
Sbjct: 735 HDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILP 794
Query: 698 HGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTA 757
GDLTEIG++GI LSGGQKQRI LARAVY+ A LLDD SAVD+HTA ++ +CI
Sbjct: 795 AGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGP 854
Query: 758 L-REKTVILVTHQVEFLSKVVDRIL---DGKVIQSGSYENLLIAGTAFEQLVN-AHKDAL 812
L + +T ILVTH V + + +GKV G+ L G E+ V + +D++
Sbjct: 855 LMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLFKEKYVQLSSRDSI 914
Query: 813 TELNQDNKNQGSSEHDVLVNP--QESHSVKEISTRGQLTKEEEKEIGDVGWKPFWDYISY 870
E N + + P + + GQL +EEEK G + + Y+ +
Sbjct: 915 NEKNANRLKAPRKNDSQKIEPVTENINFDANFVNDGQLIEEEEKSNGAISPDVYKWYLKF 974
Query: 871 SKGSLMLCFIVLAQSAFMALQTASSFWLA-------IAIEIPKVTSANL----------- 912
G L + L + S+W+ + I P L
Sbjct: 975 FGGFKALTALFALYITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKN 1034
Query: 913 -------IGVYSLISFTGVMFVYIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTP 965
+ VY LI M ++ + G+ AS F++ + ++ + FFD TP
Sbjct: 1035 KHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTP 1094
Query: 966 A-------SSDLSILDFDMPHAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIF 1018
S D+ +D ++ + + I+ II ++ +T + L VAV V F
Sbjct: 1095 VGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFF 1154
Query: 1019 IQHYYQATARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATL 1078
+ +Y +REL R++ TK+P+ +ET +GV TIRAF R + + +D +
Sbjct: 1155 VGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRA 1214
Query: 1079 FFHSNVAMEWMVIRIEALQTLTVITAALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFW 1138
FF+ +V ++W R++ + V+ + ILL + GL G+SL+YA T ++
Sbjct: 1215 FFYLSVTVKWFSFRVDMIGAFIVLASGSF-ILLNIANIDSGLAGISLTYAILFTDGALWL 1273
Query: 1139 TRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNR-----PPSPWPSKGRIEVQGLEIRY 1193
R +ST N+ SVER+K++ I E ++ R PS WP G IE++ L +RY
Sbjct: 1274 VRLYSTFEMNMNSVERLKEYSSIEQENYLGHDEGRILLLNEPS-WPKDGEIEIENLSLRY 1332
Query: 1194 RPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIG 1253
PN P V++ ++ + S++G+VGRTG+GKST+I+ALFRL+EP G I IDG +I I
Sbjct: 1333 APNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKID 1392
Query: 1254 LKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHL------KETIS--- 1304
L LR ++IIPQ+P LF G+I++N+DP Y + +I+KAL + +L +E ++
Sbjct: 1393 LVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEE 1452
Query: 1305 RLPSL------LDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAI 1358
R S L + +++ G N S G+RQL + R LL+ KI++LDEAT+SID +D +
Sbjct: 1453 RFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSIDYDSDHL 1512
Query: 1359 LQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLME 1407
+Q +IR EF + T++TIAHR+ +VID D ++++ G++ EYD PS+L++
Sbjct: 1513 IQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLK 1561
>ACC9_MOUSE (P70170) Sulfonylurea receptor 2
Length = 1546
Score = 582 bits (1500), Expect = e-165
Identities = 401/1332 (30%), Positives = 669/1332 (50%), Gaps = 121/1332 (9%)
Query: 195 LLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTK 254
LLSK + W+N+L+ + KP+ L+ I L A T Y +E +K + + +
Sbjct: 222 LLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNR 281
Query: 255 NLVLW-SIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNLREG------ 307
+W ++ + + + +L + + L + PL + V + RE
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEKTNTTREMFPETLS 341
Query: 308 ----------LSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSS 357
L+++ FL L L +F Q ++ G+ +R AL+ +Y K L+LS+S
Sbjct: 342 SKEFLENAHVLAVLLFLALI-LQRTFLQASYYVTIET-GINLRGALLAMIYNKILRLSTS 399
Query: 358 GKI--RHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLV 415
+ G+I N +A++ ++ F + W +Q+++ + +L+ ++G AL G
Sbjct: 400 NLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAA 459
Query: 416 PLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESL 475
+V+ + A L Q + ERL+ T+EIL +K++KL +WE F VE
Sbjct: 460 VIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET 519
Query: 476 RDKEFVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSM 535
R KE L + + S F+ P F+ A ++ L F L+ +
Sbjct: 520 RMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL 579
Query: 536 GDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHND-----------DNSEKHIKHCSSN 584
P+ ++ + ++ +S +LN FLL +E+ D ++ +KH S
Sbjct: 580 VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGVQSKP 639
Query: 585 V----------------------------VEIQAGNFTWDLESVSPTLTDVNLEIKRGQK 616
+ +++ G F+W S TL+++++ I GQ
Sbjct: 640 INRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWG--SGLATLSNIDIRIPTGQL 697
Query: 617 IAVCGPVGAGKSSLLYAILGEIPNIQGTV---NVGG--------------TLAYVSQSSW 659
+ G VG GKSSLL AILGE+ ++G V NV ++AY +Q W
Sbjct: 698 TMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPW 757
Query: 660 IQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRI 719
+ + TV +NI FG P N+ RY+ AC+L DI+ L GD TEIG+RGINLSGGQ+QRI
Sbjct: 758 LLNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 817
Query: 720 QLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALRE--KTVILVTHQVEFLSKV- 776
+ARA+Y + +I LDDPFSA+D H + L + I+ L++ +TV+LVTH++++L+
Sbjct: 818 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHAD 877
Query: 777 -VDRILDGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQDNKNQGSSEHDVLVNPQE 835
+ + DG V++ G+ +++ T +L K + +Q+ + ++ L
Sbjct: 878 WIIAMKDGSVLREGTLKDI---QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTL 934
Query: 836 SHSVKEISTRGQLTKEEEKEIGD----------------VGWKPFWDYISYSKGSLMLCF 879
++ + Q+ E+E+E + + WK W Y++ S G +L
Sbjct: 935 RRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWKTCWWYLT-SGGFFLLFL 993
Query: 880 IVLAQSAFMALQTASSFWLA-----IAIEIP-KVTSANLIGVYSLISFTGVMFVYIRSYL 933
++ ++ ++ A +WLA +I P K + +S++ G+ + S
Sbjct: 994 MIFSKLLKHSVIVAIDYWLATWTSEYSINHPGKADQTFYVAGFSILCGAGIFLCLVTSLT 1053
Query: 934 MARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALS 986
+ +GL A+ + I P+ FFD+TP S+D +I+D +P +
Sbjct: 1054 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTR 1113
Query: 987 VAIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAA 1046
+ L I +++ T L+ P VA FIQ Y++ +++L ++ +T+ P++ +
Sbjct: 1114 STLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFS 1173
Query: 1047 ETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAAL 1106
ET+ G+ TIRAF R + L+L DT+ + + A W+ +R + L V+TA++
Sbjct: 1174 ETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASI 1233
Query: 1107 LLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEP- 1165
I G + GLVGL L YA +T + R + L + +V+++ F+ + +E
Sbjct: 1234 ASI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENY 1290
Query: 1166 PAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKS 1225
M+ ++ P WP +G I++ L +RY N VLK + G +VG+ GRTGSGKS
Sbjct: 1291 EGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS 1350
Query: 1226 TLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLY 1285
+L A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF GSIR NLDP
Sbjct: 1351 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1410
Query: 1286 TDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLD 1345
TD+ +W+ALE LK + LP LD++V++ G N+S+GQRQLFCL R ++++ IL++D
Sbjct: 1411 TDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1470
Query: 1346 EATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDE-PSK 1404
EATASID AT+ ILQ+V+ FA+ TV+TIAHR+ +++D+ +V++ S G LVE D P+
Sbjct: 1471 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIVDAGLVLVFSEGILVECDTGPNL 1530
Query: 1405 LMETNSSFSKLV 1416
L N FS LV
Sbjct: 1531 LQHKNGLFSTLV 1542
>ACC8_HUMAN (Q09428) Sulfonylurea receptor 1
Length = 1580
Score = 580 bits (1496), Expect = e-165
Identities = 391/1358 (28%), Positives = 665/1358 (48%), Gaps = 151/1358 (11%)
Query: 195 LLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTK 254
LLSK + W+N+ + + KP+ L I L A T YQ +++ RK + +
Sbjct: 223 LLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQG 282
Query: 255 NLVLWSIVK-TYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNLREGLSIVG- 312
+W + + + +L + + +L + PL ++ V++ + + +G
Sbjct: 283 ARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGV 342
Query: 313 -----------------FLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLS 355
L L L++ + ++ + G+ +R A+ +Y K + LS
Sbjct: 343 YFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLS 402
Query: 356 SSGKI--RHSAGEIVNYIAVDAYRMGEFPWWFHIT---WTCILQLVLSIAVLFGVVGIGA 410
+S +AG+I N +A+D + W+F + W +Q+++ + +L+ ++G+ A
Sbjct: 403 TSNLSMGEMTAGQICNLVAIDT---NQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSA 459
Query: 411 LPGLVPLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKN 470
L G +++ + A L Q + +ERL+ T+E+L +K++KL +WE F+
Sbjct: 460 LIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRT 519
Query: 471 LVESLRDKEFVWLSKSQILKASSSFLFWMSPTIISSVVFLG-CAISNSAPLNAQTIFTVL 529
VE+ R KE L I + S F+ P + F+G + A + F L
Sbjct: 520 RVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASL 579
Query: 530 ATLKSMGDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHNDD----------------- 572
+ + P+ ++ + ++ VS +L+ FL E+ +
Sbjct: 580 SLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQA 639
Query: 573 ------NSEKHIKH-------------------CSSNVVEIQAGNFTWDLESVSPTLTDV 607
N ++ + + V+I G FTW + + PTL+++
Sbjct: 640 VPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGI-PTLSNI 698
Query: 608 NLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTV--------NVG----------- 648
+ I RGQ + G VG GKSSLL A LGE+ + G V +G
Sbjct: 699 TIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETAT 758
Query: 649 -------GTLAYVSQSSWIQSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDL 701
G +AY SQ W+ + TV +NI+F P NK RY+ I+AC+L DI+ L HGD
Sbjct: 759 DLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQ 818
Query: 702 TEIGQRGINLSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALRE- 760
T+IG+RGINLSGGQ+QRI +ARA+Y A++ LDDPFSA+D H + L I+ LR+
Sbjct: 819 TQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDD 878
Query: 761 -KTVILVTHQVEFLSKV--VDRILDGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQ 817
+TV+LVTH++++L + + DG + + G+ ++ + QL K + +Q
Sbjct: 879 KRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC---QLFEHWKTLMNRQDQ 935
Query: 818 DNKNQGSSEHDVLVNPQESHSVKEISTRGQLTKEEEKEI-------------------GD 858
+ + + +E PQ + +S+R L ++EE+E +
Sbjct: 936 ELEKETVTERKATEPPQGLS--RAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAE 993
Query: 859 VGWKPFWDYISYSKGSLMLCFIVLAQSAFMALQTASSFWLAIAIE-----IPKVTSANLI 913
+ W+ Y+S S G L+L +V +Q + A +WLA + P + +L
Sbjct: 994 IPWRACAKYLS-SAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLS 1052
Query: 914 G-----------VYSLISFTGVMFVYIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFD 962
V++++ G++ + S + GL + S I +PM FF+
Sbjct: 1053 QECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFE 1112
Query: 963 STPA-------SSDLSILDFDMPHAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVA 1015
+TP SSD + +D +P + + + + +++ VT L+ +P +
Sbjct: 1113 TTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIV 1172
Query: 1016 SIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTD 1075
FIQ Y++ +R+L +++ TT+ P+++ AET G+ TIRAF R + L+ D++
Sbjct: 1173 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1232
Query: 1076 ATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLP-HGYVSPGLVGLSLSYAFNLTGA 1134
A W+ +R+E + V+ AA+ I H +S GLVGL L+YA ++
Sbjct: 1233 NIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNY 1292
Query: 1135 QIFWTRWFSTLSNNIISVERIKQFIDIPAEP-PAIMEDNRPPSPWPSKGRIEVQGLEIRY 1193
+ R + + + +V+RI + AE ++ + P WP +G+I++Q L +RY
Sbjct: 1293 LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY 1352
Query: 1194 RPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIG 1253
+ VLK + + G ++G+ GRTGSGKS+ A FR+V+ G IIIDGI+I +
Sbjct: 1353 DSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLP 1412
Query: 1254 LKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSS 1313
L LR +LSII Q+P LF G+IR NLDP +D+ +W+ALE LK + LP LD+
Sbjct: 1413 LHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAI 1472
Query: 1314 VSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAILQRVIRQEFAECTVI 1373
+++ G N+S GQRQLFCL R +++ I ++DEATASID AT+ ILQ+V+ FA+ TV+
Sbjct: 1473 ITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVV 1532
Query: 1374 TIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSS 1411
TIAHR+ T++ +D+V++L G ++E+D+P KL+ S
Sbjct: 1533 TIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS 1570
>ACC9_RAT (Q63563) Sulfonylurea receptor 2
Length = 1545
Score = 579 bits (1492), Expect = e-164
Identities = 398/1330 (29%), Positives = 667/1330 (49%), Gaps = 118/1330 (8%)
Query: 195 LLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTK 254
LLSK + W+N+L+ + KP+ L+ I L A T Y +E +K + + +
Sbjct: 222 LLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNR 281
Query: 255 NLVLW-SIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGNLR-------- 305
+W ++ + + + +L + + L + PL + V + + N
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEPKNNTTRFSETLSS 341
Query: 306 ----EGLSIVGFLILTKLV--ESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGK 359
E ++ L+ L+ +F Q ++ G+ +R AL+ +Y K L+LS+S
Sbjct: 342 KEFLENAHVLAVLLFLALILQRTFLQASYYVTIET-GINLRGALLAMIYNKILRLSTSNL 400
Query: 360 I--RHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPL 417
+ G+I N +A++ ++ F + W +Q+++ + +L+ ++G AL G +
Sbjct: 401 SMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVI 460
Query: 418 VICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRD 477
V+ + A L Q + ERL+ T+EIL +K++KL +WE F VE R
Sbjct: 461 VLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRM 520
Query: 478 KEFVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSMGD 537
KE L + + S F+ P F+ A ++ L F L+ +
Sbjct: 521 KELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVT 580
Query: 538 PVKMIPEALSILIQVKVSFDRLNNFLLDEELHND-----------DNSEKHIKHCSSNV- 585
P+ ++ + ++ +S +LN FLL +E+ D ++ +KH S +
Sbjct: 581 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLPFESCKKHTGVQSKPIN 640
Query: 586 ---------------------------VEIQAGNFTWDLESVSPTLTDVNLEIKRGQKIA 618
+++ G F+W S TL+++++ I GQ
Sbjct: 641 RKQPGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWG--SGLATLSNIDIRIPTGQLTM 698
Query: 619 VCGPVGAGKSSLLYAILGEIPNIQGTV---NVGG--------------TLAYVSQSSWIQ 661
+ G VG GKSSLL AILGE+ ++G V NV ++AY +Q W+
Sbjct: 699 IVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLL 758
Query: 662 SGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQL 721
+ TV +NI FG N+ RY+ AC+L DI+ L GD TEIG+RGINLSGGQ+QRI +
Sbjct: 759 NATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 818
Query: 722 ARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALRE--KTVILVTHQVEFLSKV--V 777
ARA+Y + +I LDDPFSA+D H + L + I+ L++ +TV+LVTH++++L+ +
Sbjct: 819 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWI 878
Query: 778 DRILDGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQDNKNQGSSEHDVLVNPQESH 837
+ DG V++ G+ +++ T +L K + +Q+ + ++ L
Sbjct: 879 IAMKDGSVLREGTLKDI---QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRR 935
Query: 838 SVKEISTRGQLTKEEEKEIGD----------------VGWKPFWDYISYSKGSLMLCFIV 881
++ + Q+ E+E+E + + WK W Y++ S G +L ++
Sbjct: 936 AMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLT-SGGFFLLFLMI 994
Query: 882 LAQSAFMALQTASSFWLA-----IAIEIP-KVTSANLIGVYSLISFTGVMFVYIRSYLMA 935
++ ++ A +WLA +I P K + +S++ G+ + S +
Sbjct: 995 FSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQTFYVAGFSILCGAGIFLCLVTSLTVE 1054
Query: 936 RLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSVA 988
+GL A+ + I P+ FFD+TP S+D +I+D +P +
Sbjct: 1055 WMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRST 1114
Query: 989 IEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAET 1048
+ L I +++ T LI P VA FIQ Y++ +++L ++ +T+ P++ +ET
Sbjct: 1115 LLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSET 1174
Query: 1049 SLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALLL 1108
+ G+ TIRAF R + L+L DT+ + + A W+ +R + L V+TA++
Sbjct: 1175 AEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIAS 1234
Query: 1109 ILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEP-PA 1167
I G + GLVGL L YA +T + R + L + +V+++ F+ + +E
Sbjct: 1235 I---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEG 1291
Query: 1168 IMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTL 1227
M+ ++ P WP +G I++ L +RY N VLK + G +VG+ GRTGSGKS+L
Sbjct: 1292 TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSL 1351
Query: 1228 ISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTD 1287
A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF GSIR NLDP TD
Sbjct: 1352 SLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTD 1411
Query: 1288 NEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEA 1347
+ +W+ALE LK + LP LD++V++ G N+S+GQRQLFCL R ++++ IL++DEA
Sbjct: 1412 DRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEA 1471
Query: 1348 TASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDE-PSKLM 1406
TASID AT+ ILQ+V+ FA+ TV+TIAHR+ +++D+ +V++ S G LVE D P+ L
Sbjct: 1472 TASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTGPNLLQ 1531
Query: 1407 ETNSSFSKLV 1416
N FS LV
Sbjct: 1532 HKNGLFSTLV 1541
>ACC9_RABIT (P82451) Sulfonylurea receptor 2
Length = 1549
Score = 578 bits (1491), Expect = e-164
Identities = 391/1331 (29%), Positives = 663/1331 (49%), Gaps = 116/1331 (8%)
Query: 195 LLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTK 254
LLSK + W+N+L+ + KP+ L+ I L A T Y +E +K + + +
Sbjct: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKAADHPNR 281
Query: 255 NLVLW-SIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEG--NLREGLS-- 309
+W ++ + + + +L + + L + PL + V + T+ N G+S
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISEI 341
Query: 310 ------------IVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSS 357
+ L L +++ + ++ + G+ +R AL+ +Y K L+LS+S
Sbjct: 342 LSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTS 401
Query: 358 GKI--RHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLV 415
+ G+I N +A++ ++ F + W +Q+++ + +L+ ++G AL G
Sbjct: 402 NLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAA 461
Query: 416 PLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESL 475
+V+ + A L Q + ERL+ T+EIL +K++KL +WE F VE
Sbjct: 462 VIVLLAPMQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET 521
Query: 476 RDKEFVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSM 535
R KE L + + S F+ P F+ A ++ L F L+ +
Sbjct: 522 RVKELSSLKAFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLQPAEAFASLSLFHIL 581
Query: 536 GDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHND------------------------ 571
P+ ++ + ++ +S +LN FLL +E+ +D
Sbjct: 582 VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGEASLPFESCKKHTGVQPKT 641
Query: 572 --------------DNSEKHIKHCSSNVVEIQAGNFTWDLESVSPTLTDVNLEIKRGQKI 617
+ S + ++ + + I+ N + S + TL+++++ I GQ
Sbjct: 642 INRKQPGRYHLDSYEQSTRRLRPMETEDIAIKVTNGCFSWGSGAATLSNIDIRIPTGQLT 701
Query: 618 AVCGPVGAGKSSLLYAILGEIPNIQGTVNVGG-----------------TLAYVSQSSWI 660
+ G VG GKSSLL AILGE+ + G V+ ++AY +Q W+
Sbjct: 702 MIVGQVGCGKSSLLLAILGEMQTLDGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWL 761
Query: 661 QSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQ 720
+ TV +NI FG P NK RY+ AC+L DI+ L GD TEIG+RGINLSGGQ +RI
Sbjct: 762 LNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQTERIC 821
Query: 721 LARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALRE--KTVILVTHQVEFLSKV-- 776
+ARA+Y + +I LDDPFSA+D H + L + I+ L++ +T++LVTH++++L+
Sbjct: 822 VARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADW 881
Query: 777 VDRILDGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQDNKNQGSSEHDVLVNPQES 836
+ + DG V++ G+ +++ T +L K + +Q+ + ++ L
Sbjct: 882 IIAMKDGSVLREGTLKDIQ---TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLR 938
Query: 837 HSVKEISTRGQLTKEEEKEIGD----------------VGWKPFWDYISYSKGSLMLCFI 880
++ + Q+ E+E+E + + WK W Y++ S G +L +
Sbjct: 939 RAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLT-SGGFFLLFLM 997
Query: 881 VLAQSAFMALQTASSFWLAIAIE------IPKVTSANLIGVYSLISFTGVMFVYIRSYLM 934
+ ++ ++ A +WLA K + +S++ G+ + S +
Sbjct: 998 IFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTV 1057
Query: 935 ARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSV 987
+GL A+ + I P+ FFD+TP S+D +I+D +P +
Sbjct: 1058 EWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRS 1117
Query: 988 AIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAE 1047
+ L I +++ T L+ VP VA FIQ Y++ +++L ++ +T+ P++ +E
Sbjct: 1118 TLLCLSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1177
Query: 1048 TSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALL 1107
T+ G+ TIRAF R + L+L DT+ + + A W+ +R + L V+TA++
Sbjct: 1178 TAEGLTTIRAFRHEARFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIA 1237
Query: 1108 LILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEP-P 1166
I G + GLVGL L YA +T + R + L + +V+++ F+ + +E
Sbjct: 1238 SI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYE 1294
Query: 1167 AIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKST 1226
M+ ++ P WP +G I++ L +RY N VLK + G +VG+ GRTGSGKS+
Sbjct: 1295 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSS 1354
Query: 1227 LISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYT 1286
L A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF GSIR NLDP T
Sbjct: 1355 LSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCT 1414
Query: 1287 DNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDE 1346
D+ +W+ALE LK + L LD+ V++ G N+S+GQRQLFCL R ++++ IL++DE
Sbjct: 1415 DDRLWEALEIAQLKNMVKSLSGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDE 1474
Query: 1347 ATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDE-PSKL 1405
ATASID AT+ ILQ+V+ FA+ TV+TIAHR+ +++D+D+V++ S G LVE D P+ L
Sbjct: 1475 ATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIVDADLVLVFSEGILVECDTGPNLL 1534
Query: 1406 METNSSFSKLV 1416
N FS LV
Sbjct: 1535 THKNGLFSTLV 1545
>ACC9_HUMAN (O60706) Sulfonylurea receptor 2
Length = 1549
Score = 577 bits (1486), Expect = e-163
Identities = 390/1331 (29%), Positives = 663/1331 (49%), Gaps = 116/1331 (8%)
Query: 195 LLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTK 254
LLSK + W+N+L+ + KP+ L+ I L A T Y +E +K + + +
Sbjct: 222 LLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNR 281
Query: 255 NLVLW-SIVKTYLQENILIAFYALLRTISVVVLPLILYAFVNYSSRTEGN------LREG 307
+W ++ + + + +L + + L + PL + V + T+ + E
Sbjct: 282 TPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISET 341
Query: 308 LSIVGFL----------ILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSS 357
LS FL L +++ + ++ + G+ +R AL+ +Y K L+LS+S
Sbjct: 342 LSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTS 401
Query: 358 GKI--RHSAGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLV 415
+ G+I N +A++ ++ F + W +Q+++ + +L+ ++G AL G
Sbjct: 402 NLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAA 461
Query: 416 PLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESL 475
+V+ + A L Q + ERL+ T+EIL +K++KL +WE F VE
Sbjct: 462 VIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET 521
Query: 476 RDKEFVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNAQTIFTVLATLKSM 535
R KE L + + S F+ P F+ A ++ L F L+ +
Sbjct: 522 RMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL 581
Query: 536 GDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHND------------------------ 571
P+ ++ + ++ +S +LN FLL +E+ +D
Sbjct: 582 VTPLSLLFTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKT 641
Query: 572 --------------DNSEKHIKHCSSNVVEIQAGNFTWDLESVSPTLTDVNLEIKRGQKI 617
+ S + ++ + + I+ N + S TL+++++ I GQ
Sbjct: 642 INRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLT 701
Query: 618 AVCGPVGAGKSSLLYAILGEIPNIQGTVNVGG-----------------TLAYVSQSSWI 660
+ G VG GKSSLL AILGE+ ++G V+ ++AY +Q W+
Sbjct: 702 MIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWL 761
Query: 661 QSGTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQ 720
+ TV +NI FG P NK RY+ AC+L DI+ L GD TEIG+RGINLSGGQ+QRI
Sbjct: 762 LNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRIC 821
Query: 721 LARAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTALRE--KTVILVTHQVEFLSKV-- 776
+ARA+Y + +I LDDPFSA+D H + L + I+ L++ +T++LVTH++++L+
Sbjct: 822 VARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADW 881
Query: 777 VDRILDGKVIQSGSYENLLIAGTAFEQLVNAHKDALTELNQDNKNQGSSEHDVLVNPQES 836
+ + DG V++ G+ +++ T +L K + +Q+ + ++ L
Sbjct: 882 IIAMKDGSVLREGTLKDIQ---TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLR 938
Query: 837 HSVKEISTRGQLTKEEEKEIGD----------------VGWKPFWDYISYSKGSLMLCFI 880
++ + Q+ E+E+E + + WK W Y++ S G +L +
Sbjct: 939 RAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLT-SGGFFLLILM 997
Query: 881 VLAQSAFMALQTASSFWLAIAIE------IPKVTSANLIGVYSLISFTGVMFVYIRSYLM 934
+ ++ ++ A +WLA K + +S++ G+ + S +
Sbjct: 998 IFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTV 1057
Query: 935 ARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSV 987
+GL A+ + I P+ FFD+TP S+D +I+D +P +
Sbjct: 1058 EWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRS 1117
Query: 988 AIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAE 1047
+ L I +++ T L+ +P VA FIQ Y++ +++L ++ +T+ P++ +E
Sbjct: 1118 TLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1177
Query: 1048 TSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALL 1107
T+ G+ TIRAF R + L+L DT+ + + A W+ +R + L V+TA++
Sbjct: 1178 TAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIA 1237
Query: 1108 LILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEP-P 1166
I G + GLVGL L YA +T + R + L + +V+++ F+ + +E
Sbjct: 1238 SI---SGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYE 1294
Query: 1167 AIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKST 1226
M+ ++ P WP +G I++ L +RY N VLK + G +VG+ GRTGSGKS+
Sbjct: 1295 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSS 1354
Query: 1227 LISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYT 1286
L A FR+V+ G I+IDGI+I + L LR +LSII Q+P LF GSIR NLDP T
Sbjct: 1355 LSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCT 1414
Query: 1287 DNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDE 1346
D+ +W+ALE LK + LP LD+ V++ G N+S+GQRQLFCL R ++++ IL++DE
Sbjct: 1415 DDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDE 1474
Query: 1347 ATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDE-PSKL 1405
ATASID AT+ ILQ+V+ FA+ TV+T+AHR+ +++D+ +V++ S G LVE D P+
Sbjct: 1475 ATASIDMATENILQKVVMTAFADRTVVTMAHRVSSIMDAGLVLVFSEGILVECDTVPNLF 1534
Query: 1406 METNSSFSKLV 1416
N FS LV
Sbjct: 1535 AHKNGPFSTLV 1545
>MRP6_MOUSE (Q9R1S7) Multidrug resistance-associated protein 6
(ATP-binding cassette, sub-family C, member 6)
Length = 1498
Score = 570 bits (1470), Expect = e-162
Identities = 397/1326 (29%), Positives = 652/1326 (48%), Gaps = 67/1326 (5%)
Query: 155 LCSYKNLGYLGTHSVPECLYSEPLLAQKCETKQTGL--SNATLLSKLVFSWVNSLLSLGY 212
L +Y L + V CL +P + + A+ SK +F W + LL GY
Sbjct: 174 LATYLCLSLVVAELVLSCLVDQPPFFSEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGY 233
Query: 213 SKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTKNLVLWSIVKTYLQEN--- 269
K L +D+ +L E+ + EW + + V + +LQ
Sbjct: 234 KKLLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHSSVGAPETEAFLQPERSQ 293
Query: 270 ---ILIAFYALLR------TISVVV-------LPLILYAFVNYSSRTEGNLREGLSIVGF 313
+L A + + R T+S+V+ +P +L F+ + + G +
Sbjct: 294 RGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSSAWTGWLLAVL 353
Query: 314 LILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSAGEIVNYIAV 373
+ +++ ++ + ++ L M++R+A+ VY K L LSS + +AG++VN ++V
Sbjct: 354 MFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSV 413
Query: 374 DAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLNVPFARILQN 433
D R+ E + + W L + + L+ ++G AL + + LN +
Sbjct: 414 DIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRGF 473
Query: 434 CQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLSKSQILKASS 493
Q + M + R R TS +L +++ IK WE F + +R +E L S +L + S
Sbjct: 474 HQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVS 533
Query: 494 SFLFWMSPTIISSVVF-LGCAISNSAPLNAQTIFTVLATLKSMGDPVKMIPEALSILIQV 552
F +S +++ VVF + ++ ++A+ F L L + +P ++ ++Q
Sbjct: 534 LVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQA 593
Query: 553 KVSFDRLNNFLLDEELHNDDNSEKHIKHCSSNVVEIQAGNFTWDLESVSPTLTDVNLEIK 612
+VSFDRL FL EE+ + + + S + + + G F W ES P L +NL +
Sbjct: 594 RVSFDRLAAFLCLEEVDPNGMIASNSRRSSKDRISVHNGTFAWSQES-PPCLHGINLTVP 652
Query: 613 RGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQSSWIQSGTVRDNILFG 672
+G +AV GPVGAGKSSLL A+LGE+ ++G+V++ G++AYV Q +W+Q+ +V +N+ F
Sbjct: 653 QGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVAENVCFR 712
Query: 673 KPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIY 732
+ ++ + + ACAL D+ G T IG++G+NLSGGQKQR+ LARAVY A IY
Sbjct: 713 QELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIY 772
Query: 733 LLDDPFSAVDAHTAAILFNDCIMTA--LREKTVILVTHQVEFLSKVVDRIL---DGKVIQ 787
LLDDP +A+DAH + +F I + L+ T ILVTH + L + DRIL +G + +
Sbjct: 773 LLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQA-DRILVLANGTIAE 831
Query: 788 SGSYENLLIAGTAFEQLVNAHK------DALTELNQDNKNQGSSE-------HDVLVNPQ 834
GSY++LL A L++ + DA T + G P
Sbjct: 832 MGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGGGRPTCRPDRPRPTEAAPV 891
Query: 835 ESHSVKEISTRGQLTKEE------EKEIGDVGWKPFWDYISYSKG-SLMLCFIVLAQSAF 887
+ S E+ L E E++ G Y+SY + LC L F
Sbjct: 892 KGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKITIYLSYLRAVGTPLCTYTLF--LF 949
Query: 888 MALQTAS---SFWLAIAIEIPKVTSANLIG-----VYSLISFTGVMFVYIRSYLMARLGL 939
+ Q AS +WL++ + P V + V+ L+ + ++ + G
Sbjct: 950 LCQQVASFSQGYWLSLWADDPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGA 1009
Query: 940 NASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDFDMPHAVHFALSVAIEVL 992
AS F S + SP+ FF+ TP S + +D D+P + L+ A +L
Sbjct: 1010 RASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLL 1069
Query: 993 VIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGV 1052
+ + T ++ +P MV Q Y AT+ +L R+ + V + AET G
Sbjct: 1070 EVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGS 1129
Query: 1053 VTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLP 1112
+ +RAF + L+D + + F VA W+ +E L V AA +L
Sbjct: 1130 LVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVL-S 1188
Query: 1113 HGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDN 1172
++S GLVG S+S A +T + R ++ L N++++VER++ + IP E P +
Sbjct: 1189 KAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTC 1248
Query: 1173 RPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALF 1232
WP G+IE + +R+RP PL ++G++ + G +VG+VGRTG+GKS+L L
Sbjct: 1249 AAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLL 1308
Query: 1233 RLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWK 1292
RL E + G+I IDG+ I +GL LR +++IIPQ+P LF GS+R NLD L +TD IW
Sbjct: 1309 RLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWA 1368
Query: 1293 ALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASID 1352
ALE LK ++ LP L + +G + S+G +QL CL R LL++ +IL+LDEATAS+D
Sbjct: 1369 ALETVQLKAFVTSLPGQLQYECAGQGDDLSVGHKQLLCLARALLRKTQILILDEATASVD 1428
Query: 1353 SATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSSF 1412
T+ +Q + + F +CT++ IAHR+ +V+D V+++ G++ E P++L+ F
Sbjct: 1429 PGTEMQMQAALERWFTQCTLLLIAHRLRSVMDCARVLVMDEGQVAESGNPAQLLAQKGLF 1488
Query: 1413 SKLVAE 1418
+L E
Sbjct: 1489 YRLAHE 1494
>MRP6_RAT (O88269) Multidrug resistance-associated protein 6
(ATP-binding cassette, sub-family C, member 6) (MRP-like
protein-1) (MLP-1)
Length = 1502
Score = 569 bits (1466), Expect = e-161
Identities = 399/1343 (29%), Positives = 660/1343 (48%), Gaps = 97/1343 (7%)
Query: 155 LCSYKNLGYLGTHSVPECLYSEPLLAQKCETKQTGL--SNATLLSKLVFSWVNSLLSLGY 212
L +Y L + V CL +P + + A+ SK +F W + LL GY
Sbjct: 174 LATYLCLSLVVAELVLSCLVDQPPFFSEDSKPLNPCPEAEASFPSKAMFWWASGLLWKGY 233
Query: 213 SKPLALEDIPTLVSEDEANTAYQNFVHEWES----------------------LGRKRSK 250
K L +D+ +L E+ + EW L +RS+
Sbjct: 234 RKLLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHKGHSGMGTPETEAFLQPERSQ 293
Query: 251 NSTKNLVLWSIVKTYLQENILIAFYALLRTISVVV-------LPLILYAFVNYSSRTEGN 303
+W + ++ LL T+S+V+ +P +L F+ + E +
Sbjct: 294 RGPLLRAIWRVFRSTF----------LLGTLSLVISDAFRFAVPKLLSLFLEFMGDLESS 343
Query: 304 LREGLSIVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHS 363
G + + L+ +++ ++ + + + L M++R+A+ VY K L LSS + +
Sbjct: 344 AWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVLSSGSRKSSA 403
Query: 364 AGEIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLL 423
AG++VN ++VD R+ E + W L +++ L+ ++G AL + + L
Sbjct: 404 AGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLSLLPL 463
Query: 424 NVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWL 483
N + Q + M + R R TS +L +++ IK WE F + +R +E L
Sbjct: 464 NFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGAL 523
Query: 484 SKSQILKASSSFLFWMSPTIISSVVF-LGCAISNSAPLNAQTIFTVLATLKSMGDPVKMI 542
S L + S F +S +++ VVF + ++ ++A+ F L L + +
Sbjct: 524 KTSAFLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFL 583
Query: 543 PEALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHIKHCSSNVVEIQAGNFTWDLESVSP 602
P ++ L+Q +VSFDRL FL EE+ + + S + + I G F W ES P
Sbjct: 584 PFSVHCLVQARVSFDRLAAFLCLEEVDPNGMVLSPSRCSSKDRISIHNGTFAWSQES-PP 642
Query: 603 TLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQSSWIQS 662
L +NL + +G +AV GPVGAGKSSLL A+LGE+ ++G+V++ G++AYV Q +W+Q+
Sbjct: 643 CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQN 702
Query: 663 GTVRDNILFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQLA 722
+V +N+ F + ++ + ++ACAL D+ G T +G++G+NLSGGQKQR+ LA
Sbjct: 703 TSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRLSLA 762
Query: 723 RAVYNDADIYLLDDPFSAVDAHTAAILFNDCIMTA--LREKTVILVTHQVEFLSKVVDRI 780
RAVY A +YL+DDP +A+DAH + +F I + L+ T ILVTH + L + D+I
Sbjct: 763 RAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQ-ADQI 821
Query: 781 L---DGKVIQSGSYENLLIAGTAFEQLVN------------AHKDAL-----------TE 814
L +G + + GSY++LL A L++ AH A T
Sbjct: 822 LVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGGTP 881
Query: 815 LNQDNKNQGSSEHDVLVNPQESH---SVKEISTRGQLTKEEEKEIGDVGWKPFWDYISYS 871
+ + + S V + E+ S+ ++ G E+ + G V Y+SY
Sbjct: 882 TRRPERPRPSDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDSVQYGRV---KSATYLSYL 938
Query: 872 KG-SLMLCFIVLAQSAFMALQTAS---SFWLAIAIEIPKVT-----SANLIGVYSLISFT 922
+ LC L F+ Q AS +WL++ + P V SA ++ L+
Sbjct: 939 RAVGTPLCTYTL--FLFLCQQVASFCQGYWLSLWADDPVVDGKQMHSALRGSIFGLLGCL 996
Query: 923 GVMFVYIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFDSTPA-------SSDLSILDF 975
+ ++ + G AS F S + SP+ FF+ TP S + I+D
Sbjct: 997 QAIGLFASMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDV 1056
Query: 976 DMPHAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMVASIFIQHYYQATARELMRING 1035
D+P + L+ A +L + ++ T ++ +P M+ Q Y AT +L R+
Sbjct: 1057 DIPDKMRTLLTYAFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLES 1116
Query: 1036 TTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDTDATLFFHSNVAMEWMVIRIEA 1095
+ + V + AET G +RAF + L+D + + F VA W+ +E
Sbjct: 1117 ASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLEL 1176
Query: 1096 LQTLTVITAALLLILLPHGYVSPGLVGLSLSYAFNLTGAQIFWTRWFSTLSNNIISVERI 1155
L V AA + L ++S GL G S+S A +T + R ++ L N++++VER+
Sbjct: 1177 LGNGLVFVAATCAV-LSKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERV 1235
Query: 1156 KQFIDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYRPNAPLVLKGITCTFNEGSRVG 1215
+ ++ P E P + + WP G+IE + +R+RP P+ ++G++ + G +VG
Sbjct: 1236 QDYVHTPKEAPWRLPSSAAQPLWPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVG 1295
Query: 1216 VVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSI 1275
+VGRTG+GKS+L L RL E + G I IDG+ I +GL LR +++IIPQ+P LF GS+
Sbjct: 1296 IVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSL 1355
Query: 1276 RTNLDPLGLYTDNEIWKALEKCHLKETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVL 1335
R NLD L TD IW ALE LK ++ LP L S +G + S+GQ+QL CL R L
Sbjct: 1356 RMNLDLLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARAL 1415
Query: 1336 LKRNKILVLDEATASIDSATDAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGK 1395
L++ +IL+LDEATAS+D T+ +Q + + FA+CTV+ IAHR+ +V++ V+++ G+
Sbjct: 1416 LRKTQILILDEATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQ 1475
Query: 1396 LVEYDEPSKLMETNSSFSKLVAE 1418
+ E P++L+ F +L E
Sbjct: 1476 VAESGSPAQLLAQKGLFYRLAQE 1498
>L259_DROME (P91660) Probable multidrug resistance-associated protein
lethal(2)03659 (Wunen region A protein)
Length = 1290
Score = 567 bits (1462), Expect = e-161
Identities = 397/1252 (31%), Positives = 631/1252 (49%), Gaps = 69/1252 (5%)
Query: 211 GYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNSTKNLVLWSIVKTYLQENI 270
GY K L D+ + E +++ WE + ++ + L + L
Sbjct: 29 GYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPG 88
Query: 271 LIAFYALL--RTISVVVLPLILYAFVNYSSRTEGNLREGLSIVGFLILTKLVESFSQRHW 328
L F L RT+ P+ L ++Y S G I+ +
Sbjct: 89 LAIFVVELGLRTLQ----PIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPT 144
Query: 329 FFNSRRLGMKMRSALMVAVYEKQLKLSSSGKIRHSAGEIVNYIAVDAYRMGEFPWWFHIT 388
F + KMR A+ ++ K L+L+ ++G +VN I+ D R+ P+ H
Sbjct: 145 TFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYL 204
Query: 389 WTCILQLVLSIAVLFGVVGIGALPGLVPLVICGLLNVPFARILQNCQSQFMIAQDERLRS 448
W LQ+++ +++ +GI A+ G++ +++ + + Q + D R+R
Sbjct: 205 WVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRM 264
Query: 449 TSEILNSMKIIKLQSWEEKFKNLVESLRDKEFVWLSKSQILKA---SSSFLFWMSPTIIS 505
+EI+++++++K+ +WE+ F+ +V R+KE + + Q ++ + + +S
Sbjct: 265 VNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLS 324
Query: 506 SV--VFLGCAISNSAPLNAQTIFTVLATLKSMGDPVKMIPEALSILIQVKVSFDRLNNFL 563
V V LG + + VL S+ +P A+ Q S R+ F+
Sbjct: 325 LVGYVILGKVFTPEIAFMITAYYNVLLAAMSI-----YVPSAIIQTAQFLTSIRRVEQFM 379
Query: 564 LDEELHNDDNSEKHIKHC------SSN--------VVEIQAGNFTWDLESVSPTLTDVNL 609
EEL + D SE K S+N + I+ WD S TL+ +NL
Sbjct: 380 QSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINL 439
Query: 610 EIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQGTVNVGGTLAYVSQSSWIQSGTVRDNI 669
EIK G +AV G G+GKSSL+ AILGE+ G + V G+L+Y SQ SW+ SGTVR NI
Sbjct: 440 EIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNI 499
Query: 670 LFGKPMNKARYENAIKACALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDA 729
LFG+PM+ RYE +K CAL+ D + L D T +G+RG LSGGQK RI LAR+VY A
Sbjct: 500 LFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKA 559
Query: 730 DIYLLDDPFSAVDAHTAAILFNDCIMTALREKTVILVTHQVEFLSKVVDRIL---DGKVI 786
IYLLDDP SAVDA A LF+ C+ LR TV+LVTHQ +FL VD+I+ +G++
Sbjct: 560 SIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPH-VDQIVILANGQIK 618
Query: 787 QSGSYENLLIAG--TAFEQLVNAHKDALTELNQDNKNQGSSEHDVLVNPQESHSVKEIST 844
G YE+LL G T L K E N N ++++V + S S+
Sbjct: 619 ALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSS 678
Query: 845 RGQLTKEEEKEIGDVGWKPFWDYISYSKGSLMLCFIVLAQSAFMA--LQTASSFWLAIAI 902
G+ E +E G + + Y + G ++ F+V+ S+ +A T ++L +
Sbjct: 679 SGK-EHVERQESGGISLALYRKY--FQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 735
Query: 903 ----------EIPKVTSANL-IGVYSLISFTGVMFVYIRSYLMARLGLNASIAYFSSFTT 951
E+ + S ++ + Y+LI V+ S+L+ + ASI ++
Sbjct: 736 KKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFN 795
Query: 952 AIFNSPMMFFDSTPASS-------DLSILDFDMPHAVHFALSVAIEVLVIICIMASVTWQ 1004
+ + M FF S D+S +D +P + + +A+ + II ++A+V
Sbjct: 796 RVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPL 855
Query: 1005 VLIVAVPAMVASIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRL 1064
+L+ + V +++ Y T+R+L R+ ++PV + A + G+ TIRA + L
Sbjct: 856 LLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVL 915
Query: 1065 MKYYLKLVDTDATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLPHGYVSPGLVGLS 1124
K + D ++ FF + + + + + L P G + VGL
Sbjct: 916 EKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPG--NGADVGLV 973
Query: 1125 LSYAFNLTGAQIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIME---DNRPPSPWPSK 1181
++ A L + R + L N + +VER+ ++ I EP ++E D +PP WP +
Sbjct: 974 ITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESI--EPEGMLEAPDDKKPPKTWPEQ 1031
Query: 1182 GRIEVQGLEIRYRPNAPL--VLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSR 1239
G I + L +RY PNA VLK ++ +VG+VGRTG+GKS+LI+ALFRL +
Sbjct: 1032 GEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTD 1090
Query: 1240 GDIIIDGINICSIGLKDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHL 1299
G ++ID + +GL DLR ++SIIPQEP LF G++R NLDP Y+D ++W LE+ L
Sbjct: 1091 GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKL 1150
Query: 1300 KETISRLPSLLDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIL 1359
KE +S LP L S +S+ G N+S+GQRQL CL R +L+ N+ILV+DEATA++D TD ++
Sbjct: 1151 KEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLI 1210
Query: 1360 QRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLMETNSS 1411
Q IR +F +CTV+TIAHR+ T+IDSD VM++ G++VE+ P +LM + S
Sbjct: 1211 QATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS 1262
>YK83_YEAST (P36028) Probable ATP-dependent permease YKR103W/YKR104W
Length = 1558
Score = 528 bits (1359), Expect = e-149
Identities = 381/1321 (28%), Positives = 660/1321 (49%), Gaps = 130/1321 (9%)
Query: 194 TLLSKLVFSWVNSLLSLGYSKPLALEDIPTLVSEDEANTAYQNFVHEWESLGRKRSKNST 253
T+ L FS ++ L+ Y L DI L +++ NF +S
Sbjct: 247 TVFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAILANF-----------EMSSK 295
Query: 254 KNLVLWSIV---KTYLQENILIAFYA-LLRTISVVVLPLILYAFVNYSSRTEGNLREGLS 309
K +L +I+ K + +AF + L + +++P IL ++VN NL
Sbjct: 296 KGRLLPNIICYFKAVFISQLFLAFVSSFLNFVPSLLMPRIL-SYVNDPKSKSWNLVS--L 352
Query: 310 IVGFLILTKLVESFSQRHWFFNSRRLGMKMRSALMVAVYEKQLKLS----SSGKIRHSAG 365
V ++++K++ + + F + M++R+ L+ +Y K L+ + S+ ++ +A
Sbjct: 353 YVSSMLVSKIIATTCRGQGLFLGEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNAS 412
Query: 366 -----------------------EIVNYIAVDAYRMGEFPWWFHITWTCILQLVLSIAVL 402
+ N +++DA+++ E F++ + V ++ +L
Sbjct: 413 TSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMIL 472
Query: 403 FGVVGIGALPGLVPLVICGLLNVPFARILQNCQSQFMIAQDERLRSTSEILNSMKIIKLQ 462
+ ++G A G L+ LN A N Q+ +I D+R SE LNS+++IKL
Sbjct: 473 YSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLL 532
Query: 463 SWEEKFKNLVESLRDKEFVWLSKSQILKASSSFLFWMSPTIISSVVFLGCAISNSAPLNA 522
+WE F + ++RD E L K + + +++ PT++S++ F + L
Sbjct: 533 AWENLFYQKIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFSVFIKFQNQTLTP 592
Query: 523 QTIFTVLATLKSMGDPVKMIPEALSILIQVKVSFDRLNNFLLDEELHNDDNSEKHIKHCS 582
FT L+ + P+ I +S+LIQ +S +R+ ++L + E + E+ S
Sbjct: 593 TIAFTALSLFAILRTPMDQIASTVSLLIQSFISLERIQDYLNESETRKYEILEQ-----S 647
Query: 583 SNVVEIQAGNFTWDLESVSPTLTDVNLEIKRGQKIAVCGPVGAGKSSLLYAILGEIPNIQ 642
+ + + W+ S L +++++ K A+ GP G+GKSSLL +LGE+ +
Sbjct: 648 NTKFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLS 707
Query: 643 GTVNVG----------------GTLAYVSQSSWIQSGTVRDNILFGKPMNKARYENAIKA 686
G + V ++AY SQ+ W+ SGT++DN++FG+ NK ++++ +K+
Sbjct: 708 GKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKS 767
Query: 687 CALDEDINDLSHGDLTEIGQRGINLSGGQKQRIQLARAVYNDADIYLLDDPFSAVDAHTA 746
C LD+DI ++ G T++G G +LSGGQ+QRI LARA+Y+ + +LDD SAVD TA
Sbjct: 768 CCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETA 827
Query: 747 AILFNDCIM-TALREKTVILVTHQVEFLSKVVDR--ILD-GKVIQSGSYENLLIAGTAFE 802
++ +C+ ++ +T I+ +H + ++K D ILD G+V G +L+ +
Sbjct: 828 LYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQGKPSDLIKSNEFLR 887
Query: 803 QLVNAHKDALTELNQDNKNQGSSEHDVLVNPQESHSVKEISTRGQLTKEEEKEIGDVGWK 862
+ +N T D K +S+ +P+ +S E+ + EE K G V +
Sbjct: 888 ESINNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAEVE-NFEETKMEGSVKFS 946
Query: 863 PF-W--DYIS-------YSKGSLMLCFIVLAQSAFMA--LQTASS----FWLAIAIE--- 903
+ W DY ++ S+++ I L+Q ++ L T SS WL +E
Sbjct: 947 AYKWLADYFGGLGVVFVFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHS 1006
Query: 904 -IPKVTSANLIGVYSLISFTGVMFVYIRSYLMARLGLNASIAYFSSFTTAIFNSPMMFFD 962
I + + +IG+ S +G +++ I S G N + F+ ++I + + F +
Sbjct: 1007 NIYFLLTYIIIGLVSSFLTSGKVWIAIIS------GTNVTKKIFAKLLSSILYAKLRFHN 1060
Query: 963 STPA-------SSDLSILDFDM-PHAVHFALSVAIEVLVIICIMASVTWQVLIVAVPAMV 1014
TP S D+ I+D + P+ + SV + L II ++ VT Q L+ A+P
Sbjct: 1061 VTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVV-CLWIILLIGYVTPQFLLFAIPLCA 1119
Query: 1015 ASIFIQHYYQATARELMRINGTTKAPVMNFAAETSLGVVTIRAFNMVDRLMKYYLKLVDT 1074
+ Y +REL RI+ +P+ AE GV TIRA R + L +D
Sbjct: 1120 LYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDR 1179
Query: 1075 DATLFFHSNVAMEWMVIRIEALQTLTVITAALLLILLPHGYVSPGLVGLSLSYAFNLTGA 1134
FF+ N+A EW+ R++ + TL + ++++++I+ Y+ GL G+ LS AF+ T
Sbjct: 1180 SNAPFFYLNMATEWITYRVDIIGTLVLFSSSVMIIMKA-SYLDAGLAGILLSNAFSFTET 1238
Query: 1135 QIFWTRWFSTLSNNIISVERIKQFIDIPAEPPAIMEDNRPPSPWPSKGRIEVQGLEIRYR 1194
+ + FS++ + SVERIK++ DIP+E + PP+ WP G +E++ L +RY
Sbjct: 1239 AQWIIKVFSSVELLMSSVERIKEYTDIPSESNGYIS---PPANWPQTGDVELKNLSLRYS 1295
Query: 1195 PNAPLVLKGITCTFNEGSRVGVVGRTGSGKSTLISALFRLVEPSRGDIIIDGINICSIGL 1254
P++ L ++ G++VG+VGRTG+GKS++I+A++RL + G I ID +I I L
Sbjct: 1296 PHSSKALDNVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPL 1355
Query: 1255 KDLRMKLSIIPQEPTLFKGSIRTNLDPLGLYTDNEIWKALEKCHLKETISRLPSL----- 1309
+ LR +S IPQ+PTLF G++R+NLDP Y+D +I+ L K L E L +
Sbjct: 1356 ERLRNSISCIPQDPTLFDGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQ 1415
Query: 1310 --------------LDSSVSDEGGNWSLGQRQLFCLGRVLLKRNKILVLDEATASIDSAT 1355
L++ V G N S GQRQL CL R +L I+++DEATASID +
Sbjct: 1416 PNFSSHKLRNRFIDLNTVVKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYIS 1475
Query: 1356 DAILQRVIRQEFAECTVITIAHRIPTVIDSDMVMILSYGKLVEYDEPSKLM-ETNSSFSK 1414
DA +Q+ IR+ T++TIAHR+ +VID D ++++ G++ EYD P L+ + N+ F +
Sbjct: 1476 DAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIFYR 1535
Query: 1415 L 1415
L
Sbjct: 1536 L 1536
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.322 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 158,200,223
Number of Sequences: 164201
Number of extensions: 6532641
Number of successful extensions: 25288
Number of sequences better than 10.0: 1007
Number of HSP's better than 10.0 without gapping: 849
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 20690
Number of HSP's gapped (non-prelim): 2909
length of query: 1436
length of database: 59,974,054
effective HSP length: 123
effective length of query: 1313
effective length of database: 39,777,331
effective search space: 52227635603
effective search space used: 52227635603
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 72 (32.3 bits)
Medicago: description of AC146563.5