BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146552.7 + phase: 0 /pseudo
(720 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CU4A_HUMAN (Q13619) Cullin homolog 4A (CUL-4A) 385 e-106
CU4B_HUMAN (Q13620) Cullin homolog 4B (CUL-4B) 383 e-105
CUL3_MOUSE (Q9JLV5) Cullin homolog 3 (CUL-3) 372 e-102
CUL3_HUMAN (Q13618) Cullin homolog 3 (CUL-3) 371 e-102
CUL1_MOUSE (Q9WTX6) Cullin homolog 1 (CUL-1) 360 9e-99
CUL1_HUMAN (Q13616) Cullin homolog 1 (CUL-1) 360 9e-99
CUL1_CAEEL (Q17389) Cullin 1 (Abnormal cell lineage 19 protein) 323 7e-88
CUL1_DROME (Q24311) Cullin homolog 1 (Lin-19 homolog protein) 318 3e-86
CUL3_CAEEL (Q17391) Cullin 3 311 3e-84
CUL3_SCHPO (Q09760) Cullin 3 homolog (Cul-3) 309 1e-83
CUL2_HUMAN (Q13617) Cullin homolog 2 (CUL-2) 295 2e-79
CUL1_SCHPO (O13790) Cullin 1 homolog (Cul-1) (Cell division cont... 293 8e-79
CUL2_MOUSE (Q9D4H8) Cullin homolog 2 (CUL-2) 292 2e-78
CUL6_CAEEL (Q21346) Cullin 6 256 1e-67
CUL2_CAEEL (Q17390) Cullin 2 255 2e-67
CUL4_CAEEL (Q17392) Cullin 4 233 1e-60
CUL5_MOUSE (Q9D5V5) Cullin homolog 5 (CUL-5) 226 1e-58
CUL5_HUMAN (Q93034) Cullin homolog 5 (CUL-5) (Vasopressin-activa... 224 5e-58
CUL5_RAT (Q9JJ31) Cullin homolog 5 (CUL-5) (Vasopressin-activate... 224 8e-58
CC53_YEAST (Q12018) Cell division control protein 53 (Cullin A) 221 4e-57
>CU4A_HUMAN (Q13619) Cullin homolog 4A (CUL-4A)
Length = 659
Score = 385 bits (988), Expect = e-106
Identities = 236/667 (35%), Positives = 377/667 (56%), Gaps = 40/667 (5%)
Query: 63 LYDKYKEAFEEYIVSTVLPSLREKHDEFM-LRELVKRWANHKIMVRWLSRFFHYLDRYFI 121
LY + ++A E+++ + +LP + D + L+++ W +H + + F +LDR ++
Sbjct: 2 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 61
Query: 122 ARRS-LPPLNEVGLACFRDLVY--KELHGKMRDAIISLIDQEREGEQIDRALLKNVLDIF 178
+ S LP + ++GL FR + K + K D I+ LI++ER GE +DR+LL+++L +
Sbjct: 62 LQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGML 121
Query: 179 VEIGMGKMDHYENDFEADMLKDTSAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAH 238
++ + Y++ FE L++T+ Y+ + + E P+Y+ + L E DRV
Sbjct: 122 SDLQV-----YKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVIT 176
Query: 239 YLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGL 298
YL S++ L+ V+ +LL + + +L+K G LL +++ DL++M++LFS++ G
Sbjct: 177 YLDHSTQKPLIACVEKQLLGEHLTAILQK---GLDHLLDENRVPDLAQMYQLFSRVRGGQ 233
Query: 299 DPVSSIFKQHVTTEGMALVKHAEDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVN 358
+ + +++ T G A+V + E +++ V+ +++ DK +
Sbjct: 234 QALLQHWSEYIKTFGTAIVINPE----------------KDKDMVQDLLDFKDKVDHVIE 277
Query: 359 SCFQNHTLFHKALKEAFEVFCNKGVAGNSSAELLATFCDNILKKGGSEKLSDEAIEETLE 418
CFQ + F +KE+FE F NK N AEL+A D+ L+ G E +DE +E TL+
Sbjct: 278 VCFQKNERFVNLMKESFETFINK--RPNKPAELIAKHVDSKLRAGNKEA-TDEELERTLD 334
Query: 419 KVVKLLAYISDKDLFAEFYRKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGM 478
K++ L +I KD+F FY+K LA+RLL KSA+ D E+S+L+KLK +CG FTSK+EGM
Sbjct: 335 KIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGM 394
Query: 479 VTDLTLAKENQTSFEEYLSNTPNADPGIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEV 538
D+ L+K+ F++++ N ++ P IDLTV +LT G+WP+Y +++L EM+K EV
Sbjct: 395 FKDMELSKDIMVHFKQHMQNQSDSGP-IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEV 453
Query: 539 FKEFYSTKTKHRKLTWIYSLGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEI 598
FK FY K RKL W +LG + +F E V+ +Q LL+FN D S+ EI
Sbjct: 454 FKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEI 513
Query: 599 MTQLNLLDEDVIRLLHSLSCAKYKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKI---- 654
+ D ++ R L SL+C K ++LIK P K + D F FN +F K+ RIKI
Sbjct: 514 KMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQ 573
Query: 655 PLPPVDEKKKVIEDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKP-DVK 713
V+E+ E V +DR+Y IDA+IVRIMK RK LG+ LV E QL KP D+K
Sbjct: 574 MKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLK 633
Query: 714 AI*KRIE 720
KRIE
Sbjct: 634 ---KRIE 637
>CU4B_HUMAN (Q13620) Cullin homolog 4B (CUL-4B)
Length = 895
Score = 383 bits (983), Expect = e-105
Identities = 240/708 (33%), Positives = 390/708 (54%), Gaps = 44/708 (6%)
Query: 22 KLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYSQPLYDKYKEAFEEYIVSTVLP 81
KLK +E + + LY + N+C+ K S LY + ++ E++I + +
Sbjct: 201 KLKEAVEAIQNSTSIKYNLEELYQAVENLCSYK----ISANLYKQLRQICEDHIKAQIHQ 256
Query: 82 SLREKHDEFM-LRELVKRWANHKIMVRWLSRFFHYLDRYFIARRS-LPPLNEVGLACFRD 139
+ D + L+++ + W NH + + F +LDR ++ + S LP + ++GL FR
Sbjct: 257 FREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRA 316
Query: 140 LVYKE--LHGKMRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGKMDHYENDFEADM 197
+ + + K D I+ LI++ER GE IDR+LL+++L + ++ + Y++ FE
Sbjct: 317 HIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQI-----YQDSFEQRF 371
Query: 198 LKDTSAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELL 257
L++T+ Y+ + + E P+Y+ + L E DR+ YL +++ L+ V+ +LL
Sbjct: 372 LEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLL 431
Query: 258 SVYASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALV 317
+ + +L+K G + LL +++ +DLS +++LFS++ G+ + + +++ G +V
Sbjct: 432 GEHLTAILQK---GLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIV 488
Query: 318 KHAEDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEV 377
+ E +++ V+++++ DK ++ CF + F A+KEAFE
Sbjct: 489 INPE----------------KDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFET 532
Query: 378 FCNKGVAGNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFY 437
F NK N AEL+A + D+ L+ G E +DE +E+ L+K++ + +I KD+F FY
Sbjct: 533 FINK--RPNKPAELIAKYVDSKLRAGNKEA-TDEELEKMLDKIMIIFRFIYGKDVFEAFY 589
Query: 438 RKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLS 497
+K LA+RLL KSA+ D E+S+L+KLK +CG FTSK+EGM D+ L+K+ F++Y+
Sbjct: 590 KKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQ 649
Query: 498 NTPNADPGIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYS 557
N N I+LTV +LT G+WP+Y +++LP EMVK E+FK FY K RKL W +
Sbjct: 650 NQ-NVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQST 708
Query: 558 LGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLS 617
LG C + +F EL V+ +Q LL+FN + S EI + D ++ R L SL+
Sbjct: 709 LGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLA 768
Query: 618 CAKYKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKI----PLPPVDEKKKVIEDVDKDR 673
C K ++L K P K I D F N F K+ RIKI V+E+ E V +DR
Sbjct: 769 CGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDR 828
Query: 674 RYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKP-DVKAI*KRIE 720
+Y IDA+IVRIMK RK L + LV E QL KP D+K KRIE
Sbjct: 829 QYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLK---KRIE 873
>CUL3_MOUSE (Q9JLV5) Cullin homolog 3 (CUL-3)
Length = 768
Score = 372 bits (954), Expect = e-102
Identities = 220/731 (30%), Positives = 391/731 (53%), Gaps = 54/731 (7%)
Query: 23 LKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYSQPLYDKYKEAFEEYIVSTVLPS 82
LKN ++ + S + LY Y M K + + LY +E E++++ V
Sbjct: 37 LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHK----HGEKLYTGLREVVTEHLINKVRED 92
Query: 83 LREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDRYFIARRSLPPLNEVGLACFRDLV- 141
+ + L+ L + W +H+ + + Y+DR ++ + ++ + +GL FRD V
Sbjct: 93 VLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVV 152
Query: 142 -YKELHGKMRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGKMDHYENDFEADMLKD 200
Y + +R ++ +I +ER+GE +DR ++N + + +G+ YE DFEA L+
Sbjct: 153 RYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEM 212
Query: 201 TSAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVY 260
++ ++ ++ ++ E+S Y+ K E + E +RV H L S+E +++ V+ EL+S +
Sbjct: 213 SAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272
Query: 261 ASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHA 320
++E E+SG +L++ K EDL+ M++LFS++P GL + ++ +G ALV
Sbjct: 273 MKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEE 332
Query: 321 EDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCN 380
+ G +++ +++L ++ ++ F N LF + + FE F N
Sbjct: 333 GE-------------GKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLN 379
Query: 381 KGVAGNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKK 440
+ S E L+ F D+ LKKG + L+++ +E L+K + L ++ +KD+F +Y++
Sbjct: 380 ---LNSRSPEYLSLFIDDKLKKG-VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQH 435
Query: 441 LARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTP 500
LARRLL +KS +DD E+++++KLK +CG QFTSK+EGM D++++ F ++L T
Sbjct: 436 LARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATG 495
Query: 501 NADPGIDLTVTVLTTGFWPSYKSF-DLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLG 559
+ G+DLTV VLTTG+WP+ + N+P E+F+ FY K R+LT + +G
Sbjct: 496 VSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMG 555
Query: 560 TCNISGKF----------------------DPKTVELVVTTYQASALLLFNSSDRLSYSE 597
+ +++ F + + L V+T+Q + L+LFN+ ++ ++ E
Sbjct: 556 SADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEE 615
Query: 598 IMTQLNLLDEDVIRLLHSLSCAK--YKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKIP 655
I + ++ + +++R L SL+C K ++L KEP +K I F N +FT K+ R+KI
Sbjct: 616 IQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQ 675
Query: 656 LPPV------DEKKKVIEDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFK 709
E+K+ + VD DR++ I+A+IVRIMKSRK + + LV E +QL F
Sbjct: 676 TVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFL 735
Query: 710 PDVKAI*KRIE 720
P I KRIE
Sbjct: 736 PSPVVIKKRIE 746
>CUL3_HUMAN (Q13618) Cullin homolog 3 (CUL-3)
Length = 768
Score = 371 bits (952), Expect = e-102
Identities = 220/731 (30%), Positives = 390/731 (53%), Gaps = 54/731 (7%)
Query: 23 LKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYSQPLYDKYKEAFEEYIVSTVLPS 82
LKN ++ + S + LY Y M K + + LY +E E++++ V
Sbjct: 37 LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHK----HGEKLYTGLREVVTEHLINKVRED 92
Query: 83 LREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDRYFIARRSLPPLNEVGLACFRDLV- 141
+ + L+ L + W +H+ + + Y+DR ++ + ++ + +GL FRD V
Sbjct: 93 VLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVV 152
Query: 142 -YKELHGKMRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGKMDHYENDFEADMLKD 200
Y + +R ++ +I +ER+GE +DR ++N + + +G+ YE DFEA L+
Sbjct: 153 RYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEM 212
Query: 201 TSAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVY 260
++ ++ ++ ++ E+S Y+ K E + E +RV H L S+E +++ V+ EL+S +
Sbjct: 213 SAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272
Query: 261 ASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHA 320
++E E+SG +L++ K EDL M++LFS++P GL + ++ +G ALV
Sbjct: 273 MKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEE 332
Query: 321 EDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCN 380
+ G +++ +++L ++ ++ F N LF + + FE F N
Sbjct: 333 GE-------------GKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLN 379
Query: 381 KGVAGNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKK 440
+ S E L+ F D+ LKKG + L+++ +E L+K + L ++ +KD+F +Y++
Sbjct: 380 ---LNSRSPEYLSLFIDDKLKKG-VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQH 435
Query: 441 LARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTP 500
LARRLL +KS +DD E+++++KLK +CG QFTSK+EGM D++++ F ++L T
Sbjct: 436 LARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATG 495
Query: 501 NADPGIDLTVTVLTTGFWPSYKSF-DLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLG 559
+ G+DLTV VLTTG+WP+ + N+P E+F+ FY K R+LT + +G
Sbjct: 496 VSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMG 555
Query: 560 TCNISGKF----------------------DPKTVELVVTTYQASALLLFNSSDRLSYSE 597
+ +++ F + + L V+T+Q + L+LFN+ ++ ++ E
Sbjct: 556 SADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEE 615
Query: 598 IMTQLNLLDEDVIRLLHSLSCAK--YKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKIP 655
I + ++ + +++R L SL+C K ++L KEP +K I F N +FT K+ R+KI
Sbjct: 616 IQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQ 675
Query: 656 LPPV------DEKKKVIEDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFK 709
E+K+ + VD DR++ I+A+IVRIMKSRK + + LV E +QL F
Sbjct: 676 TVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFL 735
Query: 710 PDVKAI*KRIE 720
P I KRIE
Sbjct: 736 PSPVVIKKRIE 746
>CUL1_MOUSE (Q9WTX6) Cullin homolog 1 (CUL-1)
Length = 776
Score = 360 bits (923), Expect = 9e-99
Identities = 236/770 (30%), Positives = 405/770 (51%), Gaps = 82/770 (10%)
Query: 5 KTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQK---------- 54
K I L+Q WD + GI ++ + YM LYT +YN CT
Sbjct: 13 KQIGLDQIWDDLRAGIQQVYT------RQSMAKSRYMELYTHVYNYCTSVHQSNQARGAG 66
Query: 55 -PPNDYSQ------------PLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWAN 101
PP+ + LY + KE + Y+ + +L + DE +L+ ++W +
Sbjct: 67 VPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTN-LLKDGEDLMDESVLKFYTQQWED 125
Query: 102 HKIMVRWLSRFFHYLDRYFI------ARRSLPPLNEVGLACFRDLVYKELHGKMRDAIIS 155
++ + L+ YL+R+++ R+ + + + L +RD +++ L+ ++ +A++
Sbjct: 126 YRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLK 185
Query: 156 LIDQEREGEQIDRALLKNVLDIFVEIGMGKMDH---------YENDFEADMLKDTSAYYS 206
LI++ER GE I+ L+ V+ +VE+G+ + D Y+ FE+ L DT +Y+
Sbjct: 186 LIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYT 245
Query: 207 RKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLE 266
R+++ ++ ++ +YM KAE L E+ RV YLH S++ +L K + L+ + LE
Sbjct: 246 RESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH----LE 301
Query: 267 KEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAEDAASN 326
H+ LL DK EDL RM+ L S+I GL + + + H+ +G+A ++ +AA N
Sbjct: 302 IFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALN 361
Query: 327 KKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGV--- 383
+++V+ V+++H KY A V S F N F AL +A F N
Sbjct: 362 -----------DPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTK 410
Query: 384 ---AGNSSAELLATFCDNILKKGGSEKLSDEA-IEETLEKVVKLLAYISDKDLFAEFYRK 439
+ + S ELLA +CD++LKK S K +EA +E+TL +V+ + YI DKD+F +FY K
Sbjct: 411 MAQSSSKSPELLARYCDSLLKK--SSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAK 468
Query: 440 KLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNT 499
LA+RL+ SA+DD E S+++KLKQ CG ++TSK++ M D+ ++K+ F+++L+N+
Sbjct: 469 MLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNS 528
Query: 500 PNADPGIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLG 559
D +D ++ VL++G WP +S LP+E+ + + F FY+++ RKLTW+Y L
Sbjct: 529 EPLD--LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLS 586
Query: 560 TCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCA 619
+ L +T+Q + LL +N+ D + ++ + + + ++L L
Sbjct: 587 KGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQIL--L 644
Query: 620 KYKILIKEPNTKTI-----LPTDYFEFNAKFTDKMRRIKIPLPPVDEKKKVIE----DVD 670
K K+L+ E + P + + +K R+ I +P E+K+ E +++
Sbjct: 645 KSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIE 704
Query: 671 KDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
+DR+ I A+IVRIMK RKVL +QQL+ E + QL FKP V I K I+
Sbjct: 705 EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCID 754
>CUL1_HUMAN (Q13616) Cullin homolog 1 (CUL-1)
Length = 776
Score = 360 bits (923), Expect = 9e-99
Identities = 236/770 (30%), Positives = 405/770 (51%), Gaps = 82/770 (10%)
Query: 5 KTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQK---------- 54
K I L+Q WD + GI ++ + YM LYT +YN CT
Sbjct: 13 KQIGLDQIWDDLRAGIQQVYT------RQSMAKSRYMELYTHVYNYCTSVHQSNQARGAG 66
Query: 55 -PPNDYSQ------------PLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWAN 101
PP+ + LY + KE + Y+ + +L + DE +L+ ++W +
Sbjct: 67 VPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTN-LLKDGEDLMDESVLKFYTQQWED 125
Query: 102 HKIMVRWLSRFFHYLDRYFI------ARRSLPPLNEVGLACFRDLVYKELHGKMRDAIIS 155
++ + L+ YL+R+++ R+ + + + L +RD +++ L+ ++ +A++
Sbjct: 126 YRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLK 185
Query: 156 LIDQEREGEQIDRALLKNVLDIFVEIGMGKMDH---------YENDFEADMLKDTSAYYS 206
LI++ER GE I+ L+ V+ +VE+G+ + D Y+ FE+ L DT +Y+
Sbjct: 186 LIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYT 245
Query: 207 RKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLE 266
R+++ ++ ++ +YM KAE L E+ RV YLH S++ +L K + L+ + LE
Sbjct: 246 RESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH----LE 301
Query: 267 KEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAEDAASN 326
H+ LL DK EDL RM+ L S+I GL + + + H+ +G+A ++ +AA N
Sbjct: 302 IFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALN 361
Query: 327 KKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGV--- 383
+++V+ V+++H KY A V S F N F AL +A F N
Sbjct: 362 -----------DPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTK 410
Query: 384 ---AGNSSAELLATFCDNILKKGGSEKLSDEA-IEETLEKVVKLLAYISDKDLFAEFYRK 439
+ + S ELLA +CD++LKK S K +EA +E+TL +V+ + YI DKD+F +FY K
Sbjct: 411 MAQSSSKSPELLARYCDSLLKK--SSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAK 468
Query: 440 KLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNT 499
LA+RL+ SA+DD E S+++KLKQ CG ++TSK++ M D+ ++K+ F+++L+N+
Sbjct: 469 MLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNS 528
Query: 500 PNADPGIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLG 559
D +D ++ VL++G WP +S LP+E+ + + F FY+++ RKLTW+Y L
Sbjct: 529 EPLD--LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLS 586
Query: 560 TCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCA 619
+ L +T+Q + LL +N+ D + ++ + + + ++L L
Sbjct: 587 KGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQIL--L 644
Query: 620 KYKILIKEPNTKTI-----LPTDYFEFNAKFTDKMRRIKIPLPPVDEKKKVIE----DVD 670
K K+L+ E + P + + +K R+ I +P E+K+ E +++
Sbjct: 645 KSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIE 704
Query: 671 KDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
+DR+ I A+IVRIMK RKVL +QQL+ E + QL FKP V I K I+
Sbjct: 705 EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCID 754
>CUL1_CAEEL (Q17389) Cullin 1 (Abnormal cell lineage 19 protein)
Length = 780
Score = 323 bits (829), Expect = 7e-88
Identities = 233/778 (29%), Positives = 391/778 (49%), Gaps = 98/778 (12%)
Query: 4 RKTIDLEQGWDFMHRGIMKLKNILEGLP----EPQFSPEDYMMLYTTIYNMCT------- 52
R T D E W K + +GL +P+DYM LYT++Y+ CT
Sbjct: 8 RMTCDSEVVW----------KKLQDGLDVAYRRENMAPKDYMTLYTSVYDYCTSITLSTS 57
Query: 53 ----QKPPNDYSQP------------LYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELV 96
+ + S P +Y + +E + Y+++ V E E +L+
Sbjct: 58 RRDGEDGRAESSTPARTAGADFVGHEMYQRVEEYVKAYVIA-VCEKGAELSGEDLLKYYT 116
Query: 97 KRWANHKIMVRWLSRFFHYLDRYFIARRSLPPLNE-------VGLACFRDLVYKELHGKM 149
W N +I + + F YL+R++I RR L +E + L ++ ++ +L K+
Sbjct: 117 TEWENFRISSKVMDGIFAYLNRHWI-RRELDEGHENIYMVYTLALVVWKRNLFNDLKDKV 175
Query: 150 RDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMG-------------KMDHYENDFEAD 196
DA++ LI ER G I+ + V++ VE+G+ K+ Y+ FE
Sbjct: 176 IDAMLELIRSERTGSMINSRYISGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVK 235
Query: 197 MLKDTSAYYSRKASNWILED-SCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNE 255
L+ T +Y+++A+N++ + DYM+K E L +E DR YL+SS++ L ++
Sbjct: 236 FLEATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQEDDRCQLYLNSSTKTPLATCCESV 295
Query: 256 LLSVYASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEG-M 314
L+S L + H G LL D + +DLSRMF+L ++P GLD + + H+ EG
Sbjct: 296 LISNQLDFL--QRHFG--GLLVDKRDDDLSRMFKLCDRVPNGLDELRKSLENHIAKEGHQ 351
Query: 315 ALVKHAEDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEA 374
AL + A +AA++ K ++V+ ++E+H++Y + VN F+N F ++L +A
Sbjct: 352 ALERVAMEAATDAK------------LYVKTLLEVHERYQSLVNRSFKNEPGFMQSLDKA 399
Query: 375 FEVFCNKGVAGN---------SSAELLATFCDNILKKGGSEKLSDEA-IEETLEKVVKLL 424
F N SAELLA +CD +L+K S K+ DEA +EE K++ +
Sbjct: 400 ATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRK--SSKMPDEAELEELQTKIMVVF 457
Query: 425 AYISDKDLFAEFYRKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTL 484
YI DKD+F++FY K ++RL+ + SA+D+ E + +TKLK CG ++T+++ MV D +
Sbjct: 458 KYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDTQV 517
Query: 485 AKENQTSFEEYLSNTPNADPGIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYS 544
+K+ F+E ++ ++ V VL++G WP++ + + LP ++ K +E+F +FY+
Sbjct: 518 SKDLTADFKEKKADM-LGQKSVEFNVLVLSSGSWPTFPTTPITLPQQLSKTIEIFGQFYN 576
Query: 545 TKTKHRKLTWIYSLGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNL 604
K R+LTW+YS I+ PK TT Q +LLFN D + +I +
Sbjct: 577 EKFNGRRLTWVYSQSRGEITSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQIAAATKM 636
Query: 605 LDED----VIRLLHSLSCAKYKILIKE---PNTKTILPTDYFEFNAKFTDKMRRIKIPLP 657
++ V L+ +L L KE P T T+ + N K + + +
Sbjct: 637 DEKSAPAIVGSLIKNLVLKADTELQKEDEVPMTATVSLNKAY-MNKKVRVDLSKFTMKQD 695
Query: 658 PVDEKKKVIEDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI 715
V + + V ++V++DR+ I A IVRIMK+RK + +QQL+ E + QL FKP V+ I
Sbjct: 696 AVRDTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMI 753
>CUL1_DROME (Q24311) Cullin homolog 1 (Lin-19 homolog protein)
Length = 774
Score = 318 bits (815), Expect = 3e-86
Identities = 218/763 (28%), Positives = 381/763 (49%), Gaps = 67/763 (8%)
Query: 4 RKTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQ--KPPNDYS- 60
+K ++L+ W + GIM++ + L Q YM YT +Y+ CT P+ S
Sbjct: 11 QKLVNLDDIWSELVEGIMQVFEHEKSLTRSQ-----YMRFYTHVYDYCTSVSAAPSGRSS 65
Query: 61 ----------QPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLS 110
+ LYD+ ++ + Y+ + +E +L K+W +++ L
Sbjct: 66 GKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLD 125
Query: 111 RFFHYLDRYFIAR------RSLPPLNEVGLACFRDLVYKELHGKMRDAIISLIDQEREGE 164
+YL+R ++ R + + + + L ++ +++ L+ + A++ I++ER+G+
Sbjct: 126 GICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGK 185
Query: 165 QIDRALLKNVLDIFVEIGMG---------KMDHYENDFEADMLKDTSAYYSRKASNWILE 215
I+R+L+++V++ +VE+ K+ Y+ +FE + DTSA+Y +++ ++
Sbjct: 186 LINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLST 245
Query: 216 DSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKE----HSG 271
++ +Y+ E L E RV + + L E + L S L+EK H+
Sbjct: 246 NTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTE 305
Query: 272 CHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHA--EDAASNKKA 329
LL D+ +DL RM+ L + + L + SI + H+ +G + DAA++ K
Sbjct: 306 FQNLLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKT 365
Query: 330 EKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGV-----A 384
+V+ ++++H KY A V + F N F AL +A F N V +
Sbjct: 366 ------------YVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANS 413
Query: 385 GNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARR 444
+ S ELLA +CD +LKK S+ D+ +E+ L +V+ + YI DKD+F ++Y K LA+R
Sbjct: 414 ASKSPELLAKYCDLLLKKS-SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKR 472
Query: 445 LLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADP 504
L+ SA+DD E +++KLKQ CG ++T K++ M D+ ++K+ + F++YL+ N
Sbjct: 473 LVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAE-KNLTM 531
Query: 505 GIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNI- 563
ID + VL++G WP S + LP+E+ + V F EFY+ + RKL W+Y + +
Sbjct: 532 EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELI 591
Query: 564 --SGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCAKY 621
+ + T L +T+Q S LL FN + ++ E++I++L L K
Sbjct: 592 MNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQIL--LKA 649
Query: 622 KILIKEPNTKTILPTDYFEFNAKFTDKMRRIKIPLPPVDEKK----KVIEDVDKDRRYAI 677
K+L N ++ P E + +K RRI I P E K V + +++DR+ I
Sbjct: 650 KVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLI 709
Query: 678 DASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
A+IVRIMK RK L + L+ E + QL FKP V I K I+
Sbjct: 710 QAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCID 752
>CUL3_CAEEL (Q17391) Cullin 3
Length = 777
Score = 311 bits (798), Expect = 3e-84
Identities = 214/768 (27%), Positives = 383/768 (49%), Gaps = 86/768 (11%)
Query: 6 TID---LEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYSQP 62
TID + Q W+ + R I +++ S + LY Y M K + +
Sbjct: 21 TIDEQYVTQTWELLKRAIQEIQR-------KNNSGLSFEELYRNAYTMVLHK----HGER 69
Query: 63 LYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDRYFIA 122
LY+ K+ ++++ S + + + L + + WA+H + + + Y+DR ++A
Sbjct: 70 LYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVA 129
Query: 123 RRS-LPPLNEVGLACFRDLVYKE--LHGKMRDAIISLIDQEREGEQIDRALLKNVLDIFV 179
+ + + P+ +GL +R + ++ + ++RDA++ LI +R+ QI+ +KN D+ +
Sbjct: 130 QNNHVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLI 189
Query: 180 EIGMGKMDHYENDFEADMLKDTSAYYSRKASNWIL--EDSCPDYMLKAEECLRREKDRVA 237
+G+ YE++FE +LK+TS YY NW+ D+C Y+ + E + E R +
Sbjct: 190 SLGIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDAC-FYLAQVEIAMHDEASRAS 248
Query: 238 HYLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPR- 296
YL +E K+L+ + + +++ + ++ ++ G +L K EDL+R+FR+F +I
Sbjct: 249 RYLDKMTEAKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDS 308
Query: 297 ------GLDPVSSIFKQHVTTEGMALVKHAEDAASNKKAEKRDIVGTQEQVFVRKVIELH 350
GL + +++ G +VK+ ED N FV ++++L
Sbjct: 309 VTVPGGGLKALLKAVSEYLNETGSNIVKN-EDLLKNPVN------------FVNELLQLK 355
Query: 351 DKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGVAGNSSAELLATFCDNILKKGGSEKLSD 410
D + + + + F + F + FE F N + S E +A + D++L+ G + +SD
Sbjct: 356 DYFSSLLTTAFADDRDFKNRFQHDFETFLN---SNRQSPEFVALYMDDMLRSG-LKCVSD 411
Query: 411 EAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDKSANDDHERSILTKLKQQCGGQ 470
++ L+ V+ L Y+ +KD+F +++++ LA+RLL DKS +DD E+++L KLK +CG Q
Sbjct: 412 AEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQ 471
Query: 471 FTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPGIDLTVTVLTTGFWPSYKSFDLNLPA 530
FT K+E M D L TSF ++ P ID+++ VLT G WP+ + + LP
Sbjct: 472 FTQKLENMFRDKELWLTLATSFRDWREAQP-TKMSIDISLRVLTAGVWPTVQCNPVVLPQ 530
Query: 531 EMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISGKF----------------------- 567
E+ E+F ++Y+ K RKLT LG ++ F
Sbjct: 531 ELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGES 590
Query: 568 ----DPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCAK--Y 621
P+ L V T+Q LL FN +R+S ++M +L + + ++ R L SL+ K
Sbjct: 591 MKERKPEHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQ 650
Query: 622 KILIKEPNTKTILP-TDYFEFNAKFTDKMRRIKIPL--------PPVDEKKKVIEDVDKD 672
+IL+++ K + +D F N F K+ R+K+ + P + E ++ +ED D
Sbjct: 651 RILVRKNKGKDAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVED---D 707
Query: 673 RRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
R+ ++A+IVRIMK+RK L + LV E +QL F P I +RIE
Sbjct: 708 RKLEVEAAIVRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIE 755
>CUL3_SCHPO (Q09760) Cullin 3 homolog (Cul-3)
Length = 785
Score = 309 bits (792), Expect = 1e-83
Identities = 221/763 (28%), Positives = 369/763 (47%), Gaps = 68/763 (8%)
Query: 7 IDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYSQPLYDK 66
+D W+ + R I + + S + LY Y + K Y + LY+
Sbjct: 20 VDFATHWEVLQRAIGDIF-------QKSTSQLSFEELYRNAYILVLHK----YGEKLYNH 68
Query: 67 YKEAFEEYIVSTVLPSLREKHDEFML----------------------------RELVKR 98
++ + +P++ + +D +L LV
Sbjct: 69 VQDVIRSRLKEETVPAIYKNYDASLLGNALLDIRKNDSYSTSWSRSLEAAHRFLSSLVNS 128
Query: 99 WANHKIMVRWLSRFFHYLDRYFIARRSLPPLNEVGLACFRDLVYK---ELHGKMRDAIIS 155
W +H + ++ +S YLD+ + P+NE G+ FR++V E+ K + I+
Sbjct: 129 WKDHIVSMQMISSVLKYLDKVYSKSADKVPVNENGIYIFREVVLLNSFEIGEKCVETILI 188
Query: 156 LIDQEREGEQIDRALLKNVLDIFVEIGMG--KMDHYENDFEADMLKDTSAYYSRKASNWI 213
L+ ER+G I+R L+ + LD+ + K Y+ F L T +Y ++S I
Sbjct: 189 LVYLERKGNTINRPLINDCLDMLNSLPSENKKETLYDVLFAPKFLSYTRNFYEIESSTVI 248
Query: 214 LEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCH 273
+Y+ KAE+ EK+R +YL + LL V++ELLS + LLE + +G
Sbjct: 249 GVFGVVEYLKKAEKRFEEEKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFF 308
Query: 274 ALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAEDAASNKKAEKR- 332
+++ E L ++ FS++ G+ + ++V G + + A K A R
Sbjct: 309 SMIDSSNFEGLQLVYESFSRVELGVKSLKKYLAKYVAHHGKLINETTSQALEGKMAVGRL 368
Query: 333 DIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGVAGNSSA-EL 391
T ++V+KV+ L D+ +++ +L +AF F V G + A E
Sbjct: 369 SSNATMATLWVQKVLALWDRLNTIISTTMDADRSILNSLSDAFVTF----VDGYTRAPEY 424
Query: 392 LATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDKSA 451
++ F D+ LKK + K + +IE TL+ V L +IS+KD+F ++Y+ LA+RLL ++S
Sbjct: 425 ISLFIDDNLKKD-ARKAIEGSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSI 483
Query: 452 NDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNT--PNADPGIDLT 509
+ D E ++++LKQ+ G FT K+EGM D+ L++E +EY N+ +A P +DL
Sbjct: 484 SSDAELGMISRLKQEAGNVFTQKLEGMFNDMNLSQE---LLQEYKHNSALQSAKPALDLN 540
Query: 510 VTVLTTGFWP---SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISGK 566
V++L + FWP S N P ++ ++ F +FY +K RKL W S+G+ ++
Sbjct: 541 VSILASTFWPIDLSPHKIKCNFPKVLLAQIDQFTDFYLSKHTGRKLLWYPSMGSADVRVN 600
Query: 567 FDPKTVELVVTTYQASALLLF---NSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCAKYKI 623
F + +L V+T + LLLF + L + EI+ + N+ D+ R L SL+CAKYKI
Sbjct: 601 FKDRKYDLNVSTIASVILLLFQDLKENQCLIFEEILEKTNIEVGDLKRNLQSLACAKYKI 660
Query: 624 LIKEPNTKTILPTDYFEFNAKFTDKMRRIKIP------LPPVDEKKKVIEDVDKDRRYAI 677
L+K+P + + D F FN F + RIKI + E+K+ +E VD+ R++
Sbjct: 661 LLKDPKGREVNAGDKFYFNENFVSNLARIKISTVAQTRVEDDSERKRTLEKVDESRKHQA 720
Query: 678 DASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
DA IVR+MK RKV + QL+ E QL F P I +RIE
Sbjct: 721 DACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKRRIE 763
>CUL2_HUMAN (Q13617) Cullin homolog 2 (CUL-2)
Length = 745
Score = 295 bits (756), Expect = 2e-79
Identities = 203/710 (28%), Positives = 343/710 (47%), Gaps = 58/710 (8%)
Query: 44 YTTIYNMCTQKPPNDYSQPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHK 103
++ IY +C P + LY + K E ++ L + ++ + W +
Sbjct: 39 FSDIYALCVAYP-EPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYH--RYWEEYS 95
Query: 104 IMVRWLSRFFHYLDRYFIARRSLP---------------PLNEVG---LACFRDLVYKEL 145
++ + YL+ FI + L PL E+G L +R L+ + L
Sbjct: 96 KGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPL 155
Query: 146 HGKMRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGK----MDHYENDFEADMLKDT 201
+ ++ I +R GE ++ ++ V++ FV + K + Y+ FE+ L +T
Sbjct: 156 QAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTET 215
Query: 202 SAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYA 261
YY ++ASN + E +C YM K L+ E+ R YLH SS K++ + Q +++ +
Sbjct: 216 GEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHL 275
Query: 262 SQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAE 321
L H+ CH ++R +K D++ M+ L + GL + + H+ EG+
Sbjct: 276 QFL----HAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLR------ 325
Query: 322 DAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCN- 380
A SN E +FV V+E+H K++ +N+ F AL +A N
Sbjct: 326 -ATSNLTQEN------MPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNY 378
Query: 381 ---KGVAGNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFY 437
K V + ELLA +CDN+LKK ++ +++ +E+ L + + YI DKD+F +FY
Sbjct: 379 REPKSVC--KAPELLAKYCDNLLKKS-AKGMTENEVEDRLTSFITVFKYIDDKDVFQKFY 435
Query: 438 RKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLS 497
+ LA+RL+ S + D E +++ KLKQ CG +FTSK+ M TD++++ + F ++
Sbjct: 436 ARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIK 495
Query: 498 NTPNA-DPGIDLTVTVLTTGFWP--SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTW 554
N D GI + VL G WP S +P E+ K V++F+ FYS RKLTW
Sbjct: 496 NQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTW 555
Query: 555 IYSLGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLH 614
++ L T + + K +VTTYQ + LL FN+S+ +SY E+ + ++++ + +
Sbjct: 556 LHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIK 615
Query: 615 SLSCAKYKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKIPLPPVDEKKKVIED----VD 670
SL K++ + + I F N F+ K + KI + + +E VD
Sbjct: 616 SL--LDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVD 673
Query: 671 KDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
+DR+ + A+IVRIMK+RKVL + L+ E + Q F P + I K IE
Sbjct: 674 EDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIE 723
>CUL1_SCHPO (O13790) Cullin 1 homolog (Cul-1) (Cell division control
53 homolog)
Length = 767
Score = 293 bits (751), Expect = 8e-79
Identities = 208/750 (27%), Positives = 360/750 (47%), Gaps = 60/750 (8%)
Query: 4 RKTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQ---------- 53
+K L WDF+ G+ + I E L E + YM LYT I+N C
Sbjct: 15 KKYDSLNGTWDFLKTGVSQ---IFERLDEGMTITK-YMELYTAIHNYCADASKTITVDNF 70
Query: 54 --KPPNDYSQPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLSR 111
+ N + LY+ EEY+ + + + E L K W R+++
Sbjct: 71 NDQTANVLGEALYNNLVLYLEEYLARLRKECISQTNHEEQLAAYAKYWTRFTTSARFINH 130
Query: 112 FFHYLDRYFIARRS------LPPLNEVGLACFRDLVYKELHGKMRDAIISLIDQEREGEQ 165
F YL+RY++ ++ + + + L + V+ + + ++ + ++R E
Sbjct: 131 LFGYLNRYWVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEP 190
Query: 166 IDRALLKNVLDIFVEIGMGKMD-------HYENDFEADMLKDTSAYYSRKASNWILEDSC 218
D ++ +D + K D Y+ FE + +++T +Y++++S ++ S
Sbjct: 191 TDMKYVEVCVDSITSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSI 250
Query: 219 PDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCHALLRD 278
DY+ KAE L E++ V YLH S+ LLE ++ L++ + L H+ +L
Sbjct: 251 TDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVL----HNDFARMLDQ 306
Query: 279 DKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAEDAASNKKAEKRDIVGTQ 338
+ ED+ RM+RL S+ P GL P+ F++ V G A V +
Sbjct: 307 NCSEDIIRMYRLMSRTPNGLQPLRQTFEEFVKRSGFAAVAKIVPQVGGE-------ADVD 359
Query: 339 EQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGV----AGNSSAELLAT 394
+ ++ ++ + VN+ F T F K+L AF N+ V + + S ELLA
Sbjct: 360 PKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNVVCQRSSSRSPELLAK 419
Query: 395 FCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDKSANDD 454
+ D+IL+K D+ +E+ L ++ + Y+ DKD+F FY K LA+RL+ S + D
Sbjct: 420 YADSILRKSNKNVDIDD-VEDCLSSIIIIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQD 478
Query: 455 HERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPG-IDLTVTVL 513
E S+L+KLK+ CG ++TSK++ M D++L++E +F + P + G ID + VL
Sbjct: 479 AESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAFWQ----LPQSRAGNIDFSALVL 534
Query: 514 TTGFWP-SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISGKFDPK-- 570
T FWP S + + +LP E+V E F+ +Y + RKL+W++ L I + +P+
Sbjct: 535 GTSFWPLSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWLFHLSKGEIKARINPQTN 594
Query: 571 -TVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCAKYKILIKEPN 629
T V+TYQ LLL+N D +Y E+ L + + +L+ K K+L+ N
Sbjct: 595 VTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFLTGILNIF--LKAKVLLLGDN 652
Query: 630 TKTILPTDYFEFNAKFTDKMRRIKIPLPPVDEKK----KVIEDVDKDRRYAIDASIVRIM 685
K P ++ N F K R+++ LP E+K + + +++DR+ + ++IVRIM
Sbjct: 653 DKLGDPNSTYKINENFRMKKIRVQLNLPIRSEQKQESLETHKTIEEDRKLLLQSAIVRIM 712
Query: 686 KSRKVLGYQQLVMECVEQLGRMFKPDVKAI 715
K+R+ L + LV E ++Q+ F P V I
Sbjct: 713 KARRTLKHVVLVKETIDQIKSRFTPKVSDI 742
>CUL2_MOUSE (Q9D4H8) Cullin homolog 2 (CUL-2)
Length = 745
Score = 292 bits (748), Expect = 2e-78
Identities = 204/713 (28%), Positives = 348/713 (48%), Gaps = 64/713 (8%)
Query: 44 YTTIYNMCTQKPPNDYSQPLYDKYK---EAFEEYIVSTVLPSLREKHDEFMLRELVKRWA 100
++ IY +C P + LY + K E+ ++ VL S +E +L + W
Sbjct: 39 FSDIYALCVAYP-EPLGERLYAETKIFLESHVRHLYKRVLES-----EEQVLVMYHRYWE 92
Query: 101 NHKIMVRWLSRFFHYLDRYFIARRSLP---------------PLNEVG---LACFRDLVY 142
+ ++ + YL+ +I + L PL E+G L +R L+
Sbjct: 93 EYSKGADYMDCLYRYLNTQYIKKNKLTEADIQYGYGGVDMNEPLMEIGELALDMWRKLMV 152
Query: 143 KELHGKMRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGK----MDHYENDFEADML 198
+ L + ++ I +R GE ++ ++ V++ FV + K + Y+ F + L
Sbjct: 153 EPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFL 212
Query: 199 KDTSAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLS 258
+T YY ++ASN + E +C YM K L+ E+ R YLH SS K++ + Q +++
Sbjct: 213 TETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVA 272
Query: 259 VYASQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVK 318
+ L HS CH++++ ++ D++ M+ L + GL + ++H+ EG+
Sbjct: 273 DHLQFL----HSECHSIIQQERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLR--- 325
Query: 319 HAEDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVF 378
A SN E +FV V+E+H K++ +N+ F AL +A
Sbjct: 326 ----ATSNLTQEH------MPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSV 375
Query: 379 CN----KGVAGNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFA 434
N K V + ELLA +CDN+LKK ++ +++ +E+ L + + YI DKD+F
Sbjct: 376 VNYREPKSVC--KAPELLAKYCDNLLKKS-AKGMTENEVEDKLTSFITVFKYIDDKDVFQ 432
Query: 435 EFYRKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEE 494
+FY + LA+RL+ S + D E +++ KLKQ CG +FTSK+ M TD++++ + F
Sbjct: 433 KFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNN 492
Query: 495 YLSNTPNA-DPGIDLTVTVLTTGFWP--SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRK 551
++ N D GI + VL G WP S +P E+ K V++F+ FYS RK
Sbjct: 493 FIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRK 552
Query: 552 LTWIYSLGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIR 611
LTW++ L T + + K +VTTYQ + LL FN+S+ +SY E+ + ++++ +
Sbjct: 553 LTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTK 612
Query: 612 LLHSLSCAKYKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKIPLPPVDEKKKVIED--- 668
+ SL K++ + + I F N F+ K + KI + + +E
Sbjct: 613 TIKSL--LDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRS 670
Query: 669 -VDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
VD+DR+ + A+IVRIMK+RKVL + L+ E + Q F P + I K IE
Sbjct: 671 AVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIE 723
>CUL6_CAEEL (Q21346) Cullin 6
Length = 729
Score = 256 bits (655), Expect = 1e-67
Identities = 191/710 (26%), Positives = 329/710 (45%), Gaps = 61/710 (8%)
Query: 36 SPEDYMMLYTTIYNMCT--------QKPPNDYSQPLYDKYKEAFEEYIVSTVLPSLREKH 87
S + YMMLY +YN+CT P S+ LY + + Y+++ + +
Sbjct: 24 SKKYYMMLYDAVYNICTTTTLANSNNNSPEFASEFLYKQLENYIRTYVIA-IRDRISACS 82
Query: 88 DEFMLRELVKRWANHKIMVRWLSRFFHYLDRYFIARR------SLPPLNEVGLACFRDLV 141
+ +L + W N K R + F YL+R F++++ + + ++ L ++
Sbjct: 83 GDELLGKCTIEWDNFKFSTRICNCIFQYLNRNFVSKKVEDKNGEIVEIYKLALDIWKAEF 142
Query: 142 YKELHGKMRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGKMDHYENDFEADMLKDT 201
+ K DAI+ LI ER G I+ + +V++ E+ D Y+ FE L T
Sbjct: 143 FDNFKVKTIDAILELILLERCGSTINSTHISSVVECLTEL-----DIYKVSFEPQFLDAT 197
Query: 202 SAYYSRKASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYA 261
+Y ++ N +++ +YM+ E L +E+ R YL S+ L++ + S+
Sbjct: 198 KLFYKQEVLN--SKETVIEYMITVENRLFQEEYRSRRYLGPSTNDLLIDSCE----SILI 251
Query: 262 SQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAE 321
S L+ HS LL K E L+RM+ L ++ GL+ + ++ + EG ++
Sbjct: 252 SDRLKFLHSEFERLLEARKDEHLTRMYSLCRRVTHGLEDLRVYLEKRILKEGHETLQRLA 311
Query: 322 DAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNK 381
+ K K ++ K++E+H+ Y +N F + LF ++L +A + F
Sbjct: 312 KDSGLKTTPKE---------YITKLLEVHEIYFNLINKAFDRNALFMQSLDKASKDFIEA 362
Query: 382 GVA---------GNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDL 432
SA+ LA +CD +LKK + K+ DE L+K + +L YIS+KD+
Sbjct: 363 NAVTMLAPEKHRSTRSADYLARYCDQLLKK--NSKVQDET---ALDKALTVLKYISEKDV 417
Query: 433 FAEFYRKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSF 492
F +Y+ + R++ + SA+DD E +T L G ++T + MV D ++K+ T F
Sbjct: 418 FQLYYQNWFSERIINNSSASDDAEEKFITNLTATEGLEYTRNLVKMVEDAKISKDLTTEF 477
Query: 493 EEYLSNTPNADPGIDLTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKL 552
++ + ID V + TTG WPS + LP E+ ++ F FY+ R+L
Sbjct: 478 KDI-----KTEKSIDFNVILQTTGAWPSLDQIKIILPRELSTILKEFDTFYNASHNGRRL 532
Query: 553 TWIYSLGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRL 612
W YS ++ K K +VT Q L LFN D + +I + + + +
Sbjct: 533 NWAYSQCRGEVNSKAFEKKYVFIVTASQLCTLYLFNEQDSFTIEQISKAIEMTAKSTSAI 592
Query: 613 LHSLSCAKYKILIKEP-NTKTILPTD-YFEFNAKFTDKMRRI----KIPLPPVDEKKKVI 666
+ SL+ +L+ + N K P D N K+ +K R+ I D + +
Sbjct: 593 VGSLNPVIDPVLVVDKGNEKDGYPPDAVVSLNTKYANKKVRVDLTTAIKKATADRETDAV 652
Query: 667 ED-VDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI 715
++ V+ DR+Y I A IVRIMK+RK L + L+ E + QL F P+V+ I
Sbjct: 653 QNTVESDRKYEIKACIVRIMKTRKSLTHTLLINEIISQLKSRFTPNVQMI 702
>CUL2_CAEEL (Q17390) Cullin 2
Length = 776
Score = 255 bits (652), Expect = 2e-67
Identities = 195/779 (25%), Positives = 364/779 (46%), Gaps = 93/779 (11%)
Query: 5 KTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYSQPLY 64
K ++ ++ W + I+ + N L + Q+ + ++ +Y++C P S+ LY
Sbjct: 7 KVVEFDKVWVQLRPSIIDIIN-LRPITNVQWHHK-----FSDVYDICVSIP-TPLSERLY 59
Query: 65 DKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDRYFIARR 124
++ K +E+ V + + + +L+E K W ++ R F YL++ F+ ++
Sbjct: 60 NEVKACIQEH-VRQKRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQK 118
Query: 125 ---------------SLPPLNEVG---LACFRDLVYKELHGKMRDAIISLIDQEREGEQI 166
+P + E+G L +++ + K + ++ ++ ID +R+G
Sbjct: 119 RCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFP 178
Query: 167 DRAL-LKNVLDIFVEIGMGKMD-----------------HYENDFEADMLKDTSAYYSRK 208
A + V++ FV++ D Y+ FE +L DT YYS
Sbjct: 179 HIANEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSAL 238
Query: 209 ASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKE 268
A + + SC +YM + L +E+ R YLH SS K++ Q ++ + +L
Sbjct: 239 AQKMLTDLSCSEYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKL---- 294
Query: 269 HSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAEDAASNKK 328
H+ CH L+ +++ +DL M+RL I GL + F+++V +G+ +A S
Sbjct: 295 HAVCHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGL-------EAVSRLT 347
Query: 329 AEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGVAGNS- 387
E Q FV V+ +++K+ + F + F L +A + N G S
Sbjct: 348 GEN------VPQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSKEPGQSV 401
Query: 388 --SAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRL 445
++E LA + D +LKK ++ LS+ +E L+ + + YI DKD+F +FY K LA RL
Sbjct: 402 PKASERLARYTDGLLKKS-TKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSKMLANRL 460
Query: 446 LFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPG 505
+ S + D E ++ KLKQ CG +FTSK+ M TD+ L++E +F++++++ P
Sbjct: 461 IASTSISMDAEELMINKLKQACGYEFTSKLSRMFTDIGLSQELSNNFDKHIADIKTVQPD 520
Query: 506 IDLTVT---VLTTGFWP--------------SYKSFDLNLPAEMVKCVEVFKEFYSTKTK 548
+ T +L G WP + + +LP + ++ F++FY+ K
Sbjct: 521 VKFVPTQTMILQAGSWPLNAPQLSTNSNNQTAQDVANFHLPRILQPVIQEFEKFYTGKHN 580
Query: 549 HRKLTWIYSLGTCNISGKFDPKTVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDED 608
RKLTW++++ ++ + K + YQ +ALL F D + +I ++ + +
Sbjct: 581 GRKLTWLFNMSQGDVRLTYLDKQYVAQMYVYQMAALLCFERRDAILVKDIGEEIGVSGDY 640
Query: 609 VIRLLHSLSCAKYKILIKEPNTKTILPTDYFEFNAKFTDKMRRIKIPLPPVD-----EKK 663
+++ + ++ + + + + + N T K + ++ P V+ E++
Sbjct: 641 LLKTIRTI----LDVTLLTCDDQNLTADSLVRLNMSMTSKRMKFRLQAPQVNKAVEKEQE 696
Query: 664 KVIE--DVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
V V +DR+Y ++ +IVRIMK+RKVL + LV E ++Q F PDV I K IE
Sbjct: 697 AVANTFQVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQTKGRFSPDVPFIKKSIE 755
>CUL4_CAEEL (Q17392) Cullin 4
Length = 840
Score = 233 bits (595), Expect = 1e-60
Identities = 184/708 (25%), Positives = 339/708 (46%), Gaps = 64/708 (9%)
Query: 43 LYTTIYNMCTQKPPNDYSQPLYDK-------YKEAFEEYIVSTVLPSLREKHDEFMLREL 95
L++ + ++C + + S+ LYD+ + ++ +E + + L E + E L +
Sbjct: 145 LFSKVRSVCDK----NQSKVLYDRLVAIVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKF 200
Query: 96 VKRWANHKIMVRWLSRFFHYLDRYFIARRS--LPPLNEVGLACFRDL----VYKELHG-K 148
+ W + + + + F +LDR + + PL E + F+ ++KE K
Sbjct: 201 GQIWQAYPVKINLIRNIFLHLDRIALGATDTEILPLWECFMQIFQKTFFPNIFKEFKATK 260
Query: 149 MRDAIISLIDQEREGEQIDRALLKNVLDIFVEIGMGKMDHYENDFEADMLKDTSAYYSRK 208
+ +A+ + + + +D L ++++D+ + H +F ++ +Y+ +
Sbjct: 261 LFNALYMAMQKIMQRYPVDSPL-RSLVDMLQTV------HVSEEFAKFLISQLREHYNNE 313
Query: 209 ASNWILEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLL-EK 267
+ + + +C DYM E+ + R V + EP L+ VQ + + Q + E
Sbjct: 314 RIDKVPKMNCNDYMEYCEDQINRYSQLVKV---NFDEPSALKDVQATVTNCLIQQAIPEI 370
Query: 268 EHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEGMALVKHAEDAASNK 327
L+ D D+ RMF L + G D V + F +++ G L+ D
Sbjct: 371 LTHDFDDLIDSDNISDIGRMFNLCRQCVGGEDEVRTQFSKYLKKRGEKLIATCPD----- 425
Query: 328 KAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCNKGVAGNS 387
D+V ++ F +KV D + + + L +AFE F NK V +
Sbjct: 426 ----EDLV-SELLAFKKKV----DFIMTGSFKSANDPVKMRQCLSDAFESFVNKQV--DR 474
Query: 388 SAELLATFCDNILKKGGSEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLF 447
SAEL++ +L D +++ +++ + L Y+ KD+F +Y++ LA+RL
Sbjct: 475 SAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKDVFEAYYKRGLAKRLFL 534
Query: 448 DKSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPGID 507
++SA+ D E+ +L KLK +CG FT K+EGM D+ ++ F +YL + +
Sbjct: 535 ERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYLEHMNKEK--AN 592
Query: 508 LTVTVLTTGFWPSYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISGKF 567
T V+T +WP+Y ++++N+P EM + +++FY + +R + W + L + IS F
Sbjct: 593 FTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHGLASAVISASF 652
Query: 568 DPK-TVELVVTTYQASALLLFNSSDRLSYSEIMTQLNLLDEDVIRLLHSLSCAKYKILI- 625
P EL+ T YQ LLLFN + + +EI+ +L+ +V++ + +L + K +
Sbjct: 653 RPGCKKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVLALLGGRDKPKVL 712
Query: 626 ---------KEPNTKTILPTDYFEFNAKFTDKMRRIKIP----LPPVDEKKKVIEDVDKD 672
K+ T L + F N+KFT+K R++I V+E K+V E+V+ D
Sbjct: 713 QRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQVNIKTAVEETKEVKEEVNSD 772
Query: 673 RRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
R+Y IDA++VRIMK+RK L +Q L+ E ++QL F I KR+E
Sbjct: 773 RQYKIDAAVVRIMKARKQLNHQTLMTELLQQL--RFPVSTADIKKRLE 818
>CUL5_MOUSE (Q9D5V5) Cullin homolog 5 (CUL-5)
Length = 780
Score = 226 bits (577), Expect = 1e-58
Identities = 182/774 (23%), Positives = 356/774 (45%), Gaps = 76/774 (9%)
Query: 1 MSERKTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYS 60
+ + ++ E WDFMH ++KL L + + + + L++ ++ +C S
Sbjct: 7 LKNKGSLQFEDKWDFMHPIVLKL------LRQESVTKQQWFDLFSDVHAVCLWDDKG--S 58
Query: 61 QPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDRYF 120
++ KE E+I L + D +L+ + W L + F L+
Sbjct: 59 SKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTL 118
Query: 121 IARRSLPP--------LNEVGLACFRDLVYKELHGKMRDAIISLIDQEREGEQIDRALLK 172
+ ++S + ++ L + + ++ + +++D+ + L+ ER GE D L+
Sbjct: 119 LGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVI 178
Query: 173 NVLDIFVEIGMG---KMDHYENDFEADMLKDTSAYYSRKASNWILEDSCPDYMLKAEECL 229
V + +V + K+ Y ++FE L T +Y +A +++ ++ +YM A+ L
Sbjct: 179 GVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKL 238
Query: 230 RREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCHALLRDDKCEDLSRMFR 289
+ E+ R YL + E +E + ++ + E + C +++ ++ E L MF
Sbjct: 239 KEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFS 298
Query: 290 LFSKIPRGLDPVSSIFKQHVTTEGMA-LVKHAEDAASNKKAEKRDIVGTQEQVFVRKVIE 348
L K+P G++P+ ++H+ + G+A +V AE + T + +V +++
Sbjct: 299 LMDKVPNGIEPMLKDLEEHIISAGLADMVAAAE------------TITTDSEKYVEQLLT 346
Query: 349 LHDKYLAYVNSCFQNHTLFHKALKEAFEVFCN-------------KGVA-----GNSSAE 390
L +++ V FQ+ F A +A++ N KGV + E
Sbjct: 347 LFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPE 406
Query: 391 LLATFCDNILKKGG-SEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDK 449
LLA +CD +L+K S+KL+ E IE L++V+ +L Y+ +KD+F +++ L RRL+ D
Sbjct: 407 LLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDI 466
Query: 450 SANDDHERSILTKLKQ-QCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPGIDL 508
SA+ + E +++ L++ + +K+ M D+ ++++ +F+E N A P +
Sbjct: 467 SADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSV 526
Query: 509 TVTVLTTGFWP-SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISGKF 567
+ +L G W S + ++LP E+ + +EFY RKL W + + I+ K
Sbjct: 527 NIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKN 586
Query: 568 DPKTVELVVTTYQASALLLFNS--SDRLSYSEIMTQLNLLDEDVIRLLHSLSC---AKYK 622
+ +L VTT+Q + L +N +++S+ + L D ++ R L SL K +
Sbjct: 587 EVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQ 646
Query: 623 ILIKEPNTKTILPTDY-----FEFNAKFT-------DKMRRI----KIPLPPVDEKKKVI 666
+L+ +P + P D+ F N F+ K +I ++ L +++
Sbjct: 647 VLLYDPQVNS--PKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEEN 704
Query: 667 EDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
E + + R +I++IMK RK + QL E VE L MF P K I +++E
Sbjct: 705 EGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQME 758
>CUL5_HUMAN (Q93034) Cullin homolog 5 (CUL-5) (Vasopressin-activated
calcium-mobilizing receptor) (VACM-1)
Length = 780
Score = 224 bits (572), Expect = 5e-58
Identities = 187/776 (24%), Positives = 355/776 (45%), Gaps = 80/776 (10%)
Query: 1 MSERKTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCT--QKPPND 58
+ + ++ E WDFM ++KL L + + + + L++ ++ +C K P
Sbjct: 7 LKNKGSLQFEDKWDFMRPIVLKL------LRQESVTKQQWFDLFSDVHAVCLWDDKGPAK 60
Query: 59 YSQPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDR 118
Q L KE E+I L + D +L+ + W L + F L+
Sbjct: 61 IHQAL----KEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEI 116
Query: 119 YFIARRSLPPLNEVGLACFRDL--------VYKELHGKMRDAIISLIDQEREGEQIDRAL 170
+ ++ + V + R L ++ + +++D+ + L+ ER GE D L
Sbjct: 117 TLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL 176
Query: 171 LKNVLDIFVEIGMG---KMDHYENDFEADMLKDTSAYYSRKASNWILEDSCPDYMLKAEE 227
+ V + +V + K+ Y ++FE L T +Y +A +++ ++ +YM A+
Sbjct: 177 VIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADA 236
Query: 228 CLRREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCHALLRDDKCEDLSRM 287
L+ E+ R YL + E +E + ++ + E + C +++ ++ E L M
Sbjct: 237 KLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLM 296
Query: 288 FRLFSKIPRGLDPVSSIFKQHVTTEGMA-LVKHAEDAASNKKAEKRDIVGTQEQVFVRKV 346
F L K+P G++P+ ++H+ + G+A +V AE + T + +V ++
Sbjct: 297 FSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAE------------TITTDSEKYVEQL 344
Query: 347 IELHDKYLAYVNSCFQNHTLFHKALKEAFEVFCN-------------KGVA-----GNSS 388
+ L +++ V FQ+ F A +A++ N KGV +
Sbjct: 345 LTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKC 404
Query: 389 AELLATFCDNILKKGG-SEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLF 447
ELLA +CD +L+K S+KL+ E IE L++V+ +L Y+ +KD+F +++ L RRL+
Sbjct: 405 PELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLIL 464
Query: 448 DKSANDDHERSILTKLKQ-QCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPGI 506
D SA+ + E +++ L++ + +K+ M D+ ++++ +F+E N A P
Sbjct: 465 DISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPAD 524
Query: 507 DLTVTVLTTGFWP-SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISG 565
+ + +L G W S + ++LP E+ + +EFY RKL W + + I+
Sbjct: 525 SVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITF 584
Query: 566 KFDPKTVELVVTTYQASALLLFNS--SDRLSYSEIMTQLNLLDEDVIRLLHSLSC---AK 620
K + +L VTT+Q + L +N +++S+ + L D ++ R L SL K
Sbjct: 585 KNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLK 644
Query: 621 YKILIKEPNTKTILPTDY-----FEFNAKFT-------DKMRRI----KIPLPPVDEKKK 664
++L+ EP + P D+ F N +F+ K +I ++ L +++
Sbjct: 645 RQVLLYEPQVNS--PKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREE 702
Query: 665 VIEDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
E + + R +I++IMK RK + QL E VE L MF P K I ++IE
Sbjct: 703 ENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIE 758
>CUL5_RAT (Q9JJ31) Cullin homolog 5 (CUL-5) (Vasopressin-activated
calcium-mobilizing receptor) (VACM-1)
Length = 780
Score = 224 bits (570), Expect = 8e-58
Identities = 182/774 (23%), Positives = 355/774 (45%), Gaps = 76/774 (9%)
Query: 1 MSERKTIDLEQGWDFMHRGIMKLKNILEGLPEPQFSPEDYMMLYTTIYNMCTQKPPNDYS 60
+ + ++ E WDFM ++KL L + + + + L++ ++ +C S
Sbjct: 7 LKNKGSLQFEDKWDFMRPIVLKL------LRQESVTKQQWFDLFSDVHAVCLWDDKG--S 58
Query: 61 QPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMVRWLSRFFHYLDRYF 120
++ KE E+I L + D +L+ + W L + F L+
Sbjct: 59 SKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTL 118
Query: 121 IARRSLPP--------LNEVGLACFRDLVYKELHGKMRDAIISLIDQEREGEQIDRALLK 172
+ ++S + ++ L + + ++ + +++D+ + L+ ER GE D L+
Sbjct: 119 LGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVI 178
Query: 173 NVLDIFVEIGMG---KMDHYENDFEADMLKDTSAYYSRKASNWILEDSCPDYMLKAEECL 229
V + +V + K+ Y ++FE L T +Y +A +++ ++ +YM A+ L
Sbjct: 179 GVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKL 238
Query: 230 RREKDRVAHYLHSSSEPKLLEKVQNELLSVYASQLLEKEHSGCHALLRDDKCEDLSRMFR 289
+ E+ R YL + E +E + ++ + E + C +++ ++ E L MF
Sbjct: 239 KEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFS 298
Query: 290 LFSKIPRGLDPVSSIFKQHVTTEGMA-LVKHAEDAASNKKAEKRDIVGTQEQVFVRKVIE 348
L K+P G++P+ ++H+ + G+A +V AE + T + +V +++
Sbjct: 299 LMDKVPGGIEPMLKDLEEHIISAGLADMVAAAE------------TITTDSEKYVEQLLT 346
Query: 349 LHDKYLAYVNSCFQNHTLFHKALKEAFEVFCN-------------KGVA-----GNSSAE 390
L +++ V FQ+ F A +A++ N KGV + E
Sbjct: 347 LFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPE 406
Query: 391 LLATFCDNILKKGG-SEKLSDEAIEETLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDK 449
LLA +CD +L+K S+KL+ E IE L++V+ +L Y+ +KD+F +++ L RRL+ D
Sbjct: 407 LLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDI 466
Query: 450 SANDDHERSILTKLKQ-QCGGQFTSKMEGMVTDLTLAKENQTSFEEYLSNTPNADPGIDL 508
SA+ + E +++ L++ + +K+ M D+ ++++ +F+E N A P +
Sbjct: 467 SADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSV 526
Query: 509 TVTVLTTGFWP-SYKSFDLNLPAEMVKCVEVFKEFYSTKTKHRKLTWIYSLGTCNISGKF 567
+ +L G W S + ++LP E+ + +EFY RKL W + + I+ K
Sbjct: 527 NIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKN 586
Query: 568 DPKTVELVVTTYQASALLLFNS--SDRLSYSEIMTQLNLLDEDVIRLLHSLSC---AKYK 622
+ +L VTT+Q + L +N +++S+ + L D ++ R L SL K +
Sbjct: 587 EVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQ 646
Query: 623 ILIKEPNTKTILPTDY-----FEFNAKFT-------DKMRRI----KIPLPPVDEKKKVI 666
+L+ +P + P D+ F N F+ K +I ++ L +++
Sbjct: 647 VLLYDPQVNS--PKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEEN 704
Query: 667 EDVDKDRRYAIDASIVRIMKSRKVLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
E + + R +I++IMK RK + QL E VE L MF P K I ++IE
Sbjct: 705 EGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIE 758
>CC53_YEAST (Q12018) Cell division control protein 53 (Cullin A)
Length = 815
Score = 221 bits (564), Expect = 4e-57
Identities = 194/811 (23%), Positives = 361/811 (43%), Gaps = 124/811 (15%)
Query: 8 DLEQGWDFMHRGIMKLKNILEGLPEPQ------FSPEDYMMLYTTIYNMCTQKPPND--- 58
DLE W+F+ GI ++ + SP YM +YT IYN C K +
Sbjct: 10 DLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHF 69
Query: 59 ------------YSQPLYDKYKEAFEEYIVSTVLPSLREKHDEFMLRELVKRWANHKIMV 106
+Y+K K + YI++ ++ + E L+ VKRW I
Sbjct: 70 STDSRTGQSTILVGSEIYEKLKNYLKNYILN-----FKQSNSETFLQFYVKRWKRFTIGA 124
Query: 107 RWLSRFFHYLDRYFI------ARRSLPPLNEVGLACFRDLVYKELHGKMRDAIISLIDQE 160
+L+ F Y++RY++ +R + +N + L ++++++ + + ++ +
Sbjct: 125 IFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLG 184
Query: 161 REGEQIDRALLKNVLDIFVEIGMGKMDH-------YENDFEADMLKDTSAYYSRKASNWI 213
REG+ I R+ + + V +G+ D Y FE LK T YY++ ++++
Sbjct: 185 REGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYL 244
Query: 214 LEDSCPDYMLKAEECLRREKDRVAHYLHSSSEPKL------------LEKVQNELLSVYA 261
+ S +Y+ +A E ++RE+ + Y ++ L +EK++NE + +
Sbjct: 245 EKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLD 304
Query: 262 SQLLEKEHSGCHALLRDDKCEDLSRMFRLFSKIPRGLDPVSSIFKQHVTTEG-------M 314
++ +EK S +AL+R D F+ IPR ++S+F+ +V G +
Sbjct: 305 ARDIEKITS-LYALIRRD-----------FTLIPR----MASVFENYVKKTGENEISSLL 348
Query: 315 ALVKH---AEDAASNKKAEKRDIVGTQEQVFVRKVIELHDKYLAYVNSCFQNHTLFHKAL 371
A+ KH + A+ KK + +++K++E+HD + N F + KAL
Sbjct: 349 AMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKAL 408
Query: 372 KEAFEVFCNKGV----------AGNSSAELLATFCDNILKKGGSEKLSDEAIEETLEKVV 421
A F N A + ++E+LA + D +LKK +++ + +E ++
Sbjct: 409 DNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDED---II 465
Query: 422 KLLAYISDKDLFAEFYRKKLARRLLFDKSANDDHERSILTKLKQQCGGQFTSKMEGMVTD 481
+ Y++DKD F YR+ A+RL+ S + + E +I+ +L+ ++T K+ M D
Sbjct: 466 TIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQD 525
Query: 482 LTLAKENQTSFEEYLSNTPNADPG--IDLTVTVLTTGFWP-SYKSFDLNLPAEMVKCVEV 538
+ L+K + F L N P+ DL VL WP SY+ + LP E+V E
Sbjct: 526 IRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEK 585
Query: 539 FKEFYSTKTKHRKLTWIYSLGTCNIS---GKFDPKTVELVVTTYQASALLLFNSSDRLSY 595
KE YS K R L W++ L + GK VT +Q + LLL+N +D L+
Sbjct: 586 LKESYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTL 645
Query: 596 SEIMTQLNLLDEDVIRLLHSLSCAKYKIL---------IKEPNTKTILPTDY--FEFNAK 644
I +L + + + + K+K++ + +P T+ L Y + N
Sbjct: 646 ENIQEGTSLTIQHIAAAM--VPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNIN 703
Query: 645 FTDKMRR---------------IKIPLPPVDEKKKVIEDVDKDRRYAIDASIVRIMKSRK 689
F ++ K+ + E +++ ++++ +R+ ++A IVRIMK+++
Sbjct: 704 FASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKR 763
Query: 690 VLGYQQLVMECVEQLGRMFKPDVKAI*KRIE 720
L + LV EC+ Q + F V + + I+
Sbjct: 764 NLPHTTLVNECIAQSHQRFNAKVSMVKRAID 794
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.137 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,848,410
Number of Sequences: 164201
Number of extensions: 3563110
Number of successful extensions: 10120
Number of sequences better than 10.0: 54
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 9909
Number of HSP's gapped (non-prelim): 64
length of query: 720
length of database: 59,974,054
effective HSP length: 118
effective length of query: 602
effective length of database: 40,598,336
effective search space: 24440198272
effective search space used: 24440198272
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Medicago: description of AC146552.7