BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146527.7 - phase: 0
(466 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
FKB4_SPOFR (Q26486) 46 kDa FK506-binding nuclear protein (EC 5.2... 129 1e-29
FKB4_DROME (P54397) 39 kDa FK506-binding nuclear protein (EC 5.2... 117 5e-26
FKB4_YEAST (Q06205) FK506-binding protein 4 (EC 5.2.1.8) (Peptid... 106 1e-22
FKB4_SCHPO (O74191) FK506-binding protein 39 kDa (EC 5.2.1.8) (P... 106 1e-22
FKB3_YEAST (P38911) FK506-binding nuclear protein (EC 5.2.1.8) (... 103 9e-22
FKBH_SCHPO (Q10175) Probable peptidyl-prolyl cis-trans isomerase... 84 1e-15
FKBP_NEIMB (P25138) FK506-binding protein (Peptidyl-prolyl cis-t... 82 4e-15
FKB2_YEAST (P32472) FK506-binding protein 2 precursor (EC 5.2.1.... 82 4e-15
FKBP_NEIMA (P56989) FK506-binding protein (Peptidyl-prolyl cis-t... 79 2e-14
ATRX_CAEEL (Q9U7E0) Transcriptional regulator ATRX homolog (X-li... 78 4e-14
FKB1_DROME (P48375) 12 kDa FK506-binding protein (FKBP) (Peptidy... 77 9e-14
FKB2_VICFA (Q41649) FK506-binding protein 2 precursor (EC 5.2.1.... 75 5e-13
FKBP_YEAST (P20081) FK506-binding protein 1 (FKBP) (Peptidyl-pro... 74 6e-13
FK22_ARATH (Q38936) FK506-binding protein 2-2 precursor (EC 5.2.... 74 6e-13
FKBY_HAEIN (P44760) Probable FKBP-type peptidyl-prolyl cis-trans... 73 2e-12
FKB2_MOUSE (P45878) FK506-binding protein 2 precursor (EC 5.2.1.... 72 2e-12
FKB2_HUMAN (P26885) FK506-binding protein 2 precursor (EC 5.2.1.... 72 2e-12
FK21_ARATH (Q38935) FK506-binding protein 2-1 precursor (EC 5.2.... 72 2e-12
FKB7_WHEAT (Q43207) 70 kDa peptidylprolyl isomerase (EC 5.2.1.8)... 70 1e-11
FKB1_RAT (Q62658) FK506-binding protein 1A (EC 5.2.1.8) (Peptidy... 70 2e-11
>FKB4_SPOFR (Q26486) 46 kDa FK506-binding nuclear protein (EC
5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase)
Length = 412
Score = 129 bits (325), Expect = 1e-29
Identities = 95/368 (25%), Positives = 176/368 (47%), Gaps = 53/368 (14%)
Query: 105 LDQEIVDNV-DKEAVDDGKKDGEDRENITIETKLKTDNVVADIQTHREAEPSDQL---AV 160
LD E +++ D+E ++ +++ E + + K K +N D +++A+P + +
Sbjct: 90 LDPEFEEDLEDEEEAEEEEEEEEAPPLVPAKNKRKLENA-NDATANKKAKPDKKAGKNSA 148
Query: 161 PSTVPDVGDMKKSKKKKKGKEKETKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGNEQNQQ 220
P+ D D + + +K ++ + N+ S ++ +A+ + D+D ++ +
Sbjct: 149 PAAESDSDDDDEDQLQKFLDGEDIDTDENDESFKMNTSAEGDDSDEEDDD----EDEEDE 204
Query: 221 QPDDKKAETTDKTLPSSQVGQGQDEKPKRKRKERSKEKTLFAADDACISNVVNLPQGNEH 280
+ DD+ E ++E PK+K+K+ P +
Sbjct: 205 EDDDEDDEE-------------EEEAPKKKKKQ---------------------PAAEQD 230
Query: 281 SNQDTVNGSVDNGAQDNPDGNQSEDKKVKKKKKKSKSQGSEVVNSDVPVSAE--QSSEMM 338
S DT SVD ++S+ +++KKK ++ Q +V D P E Q +E
Sbjct: 231 STLDTSKESVDMSKL-----SKSQKRRLKKKLQQQAKQQPQVNGVDKPKKEEPQQKAEKK 285
Query: 339 KEDGNNVE-DTKPSQVRTLSNGLVIQELETGKENGKIAAIGKKISINYTGKLKENGVVVE 397
K + E + + + ++ G+ I++L+ G +G +A GK + + Y G+LK+N + +
Sbjct: 286 KPEAKKEEAPVEKKEKKQIAGGVSIEDLKVG--SGPVAKAGKVVMVYYEGRLKQNNKMFD 343
Query: 398 SNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPPNSWLV 457
+ FKFRLG EVI GWD+G+ GM+VG KR++V PP+M G IPPNS LV
Sbjct: 344 NCVKGPGFKFRLGSKEVISGWDVGIAGMKVGGKRKIVCPPAMAYGAKGSPPVIPPNSTLV 403
Query: 458 YDFELVKV 465
++ +L V
Sbjct: 404 FEVDLKNV 411
Score = 34.7 bits (78), Expect = 0.54
Identities = 39/186 (20%), Positives = 68/186 (35%), Gaps = 32/186 (17%)
Query: 7 KEAIDAGKKDSEDHENSIIETKLKTDNAFTESQIHSREAGPSDHLVDPCTVPDVGDIKKS 66
K + A + DS+D + ++ L ++ T+ S + S GD
Sbjct: 145 KNSAPAAESDSDDDDEDQLQKFLDGEDIDTDENDESFKMNTSAE----------GDDSDE 194
Query: 67 KKKKKGKEKETKSSSNGDSTELDNAEQDEPKMNMAQDLLDQEIVDNVDKEAVDDGK--KD 124
+ + +E E D E D E++ PK Q +Q+ + KE+VD K K
Sbjct: 195 EDDDEDEEDEE------DDDEDDEEEEEAPKKKKKQPAAEQDSTLDTSKESVDMSKLSKS 248
Query: 125 GEDRENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDVGDMKKSKKKKKGKEKET 184
+ R ++ + K V + ++ EP K KKK + K++E
Sbjct: 249 QKRRLKKKLQQQAKQQPQVNGVDKPKKEEP--------------QQKAEKKKPEAKKEEA 294
Query: 185 KSSSNE 190
E
Sbjct: 295 PVEKKE 300
>FKB4_DROME (P54397) 39 kDa FK506-binding nuclear protein (EC
5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase)
Length = 357
Score = 117 bits (294), Expect = 5e-26
Identities = 87/314 (27%), Positives = 137/314 (42%), Gaps = 52/314 (16%)
Query: 153 EPSDQLAVPSTVPDVGDMKKSKKKKKGKEKETKSSSNEHSTDLDNAAQDEPKMNMDEDLL 212
E DQ+ + + + +K SKK + +++ +E TD D+ +E + L
Sbjct: 96 EDDDQMTIENLLNSKA-IKNSKKSEDDEDENESGEEDEEDTDDDSQIIEE----YESFLE 150
Query: 213 TGNEQNQQQPDDKKAETTDKTLPSSQVGQGQDEKPKRKRKERSKEKTLFAADDACISNVV 272
G E++ D+ E+ ++ S + ++E+PK K V
Sbjct: 151 NGEEEDDDDVDEDNEESGEEDEQDSDDSEAEEEQPKAK--------------------VA 190
Query: 273 NLPQGNEHSNQDTVNGSVDNGAQDNPDGNQSEDKKVKKKKKKSKSQGSEVVNSDVPVSAE 332
L G +G NG + Q + KK K + KK + + E P +
Sbjct: 191 KLSPGASAKK----SGKEQNGVAKKEEAKQQQKKKEKPEAKKEQPKAKE------PAKQQ 240
Query: 333 QSSEMMKEDGNNVEDTKPSQVRTLSNGLVIQELETGKENGKIAAIGKKISINYTGKLKEN 392
+S+ RT++ G+ I + GK G+ A GK++S+ Y G+L+ N
Sbjct: 241 PASK---------------DPRTITGGVKIVDQVVGK--GEEAKQGKRVSVYYIGRLQSN 283
Query: 393 GVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPP 452
+S PFKF LG GEVI+GWD+G+ GM+VG KR + PP M G I P
Sbjct: 284 NKTFDSLLKGKPFKFALGGGEVIKGWDVGVAGMKVGGKRVITCPPHMAYGARGAPPKIGP 343
Query: 453 NSWLVYDFELVKVH 466
NS LV++ EL VH
Sbjct: 344 NSTLVFEVELKAVH 357
Score = 43.1 bits (100), Expect = 0.002
Identities = 41/203 (20%), Positives = 85/203 (41%), Gaps = 35/203 (17%)
Query: 53 DPCTVPDVGDIKKSKKKKKGKEKETKSSSNGDSTELDNAEQDEPKMNMAQDLLD---QEI 109
D T+ ++ + K K KK ++ E ++ S + E + + D + + L+ +E
Sbjct: 99 DQMTIENLLNSKAIKNSKKSEDDEDENESGEEDEE--DTDDDSQIIEEYESFLENGEEED 156
Query: 110 VDNVDKEAVDDGKKDGEDRENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDVGD 169
D+VD++ + G++D +D ++ EAE A + +
Sbjct: 157 DDDVDEDNEESGEEDEQDSDD-------------------SEAEEEQPKAKVAKLSPGAS 197
Query: 170 MKKSKKKKKGKEKETKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGNEQNQQQP--DDKKA 227
KKS K++ G K+ ++ + + A +++PK E +QQP D +
Sbjct: 198 AKKSGKEQNGVAKKEEAKQQQKKKEKPEAKKEQPK---------AKEPAKQQPASKDPRT 248
Query: 228 ETTDKTLPSSQVGQGQDEKPKRK 250
T + VG+G++ K ++
Sbjct: 249 ITGGVKIVDQVVGKGEEAKQGKR 271
>FKB4_YEAST (Q06205) FK506-binding protein 4 (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase)
Length = 392
Score = 106 bits (265), Expect = 1e-22
Identities = 110/377 (29%), Positives = 167/377 (44%), Gaps = 47/377 (12%)
Query: 113 VDKEAVDDGKKDGEDR-----ENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDV 167
+D E DD KK R +T DN D E+E + VP
Sbjct: 38 IDPEPFDDDKKPSTLRIIKRNPELTRGEYYNQDN--NDGLEEDESESEQEADVP------ 89
Query: 168 GDMKKSKKKKKGKEKETKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGNEQNQQQ------ 221
K+S K KKGK E S +E S D +N DE + + LLT + + Q Q
Sbjct: 90 ---KRSVKSKKGKAVE--QSESEDSED-ENEIDDEFEECV---LLTLSPKGQYQQALDIT 140
Query: 222 --PDDKKAETTDKTLPSSQVGQGQDEKPKRKRKERSKEKTLFAADDACISNVVNLPQGNE 279
P++ + S G E+ ++ +++ SN + E
Sbjct: 141 IAPEEDVQFVVTGSYTISLTGNYVKHPFDNSSDSDEDEEDYYSDEES--SNGEEEEEEEE 198
Query: 280 HSNQDTVNGSVD-------NGAQDNPDGNQSEDKKVKKKKKKSKSQGSE-VVNSDVPVSA 331
+++ +G D + + D +D+K K KK SK + E S P
Sbjct: 199 EDDEELSSGDDDLDDLVDASDIESRLDELVKKDEKKKNNKKDSKRKHEEDEEESAKPAEK 258
Query: 332 EQSSEMMK--EDGNNVEDTKPS-QVRTLSNGLVIQELETGKENGKIAAIGKKISINYTGK 388
+Q+++ K E + E++KP + + L G++I++ TGK G A G ++ + Y GK
Sbjct: 259 KQTTKKDKKAEKVKDSEESKPKPKTKLLEGGIIIEDRVTGK--GPHAKKGTRVGMRYVGK 316
Query: 389 LKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPPSMTSKKDGESE 448
LK NG V + N PF F+LG+GEVI+GWDIG+ GM VG +RR+V+P K
Sbjct: 317 LK-NGKVFDKNTKGKPFVFKLGQGEVIKGWDIGVAGMAVGGERRIVIPAPYAYGKQA-LP 374
Query: 449 NIPPNSWLVYDFELVKV 465
IP NS L +D +LV +
Sbjct: 375 GIPANSELTFDVKLVSM 391
Score = 38.9 bits (89), Expect = 0.028
Identities = 51/210 (24%), Positives = 92/210 (43%), Gaps = 36/210 (17%)
Query: 64 KKSKKKKKGKE-KETKSSSNGDSTELDNAEQD------EPKMNMAQDLLDQEIVDNVDKE 116
K+S K KKGK ++++S + D E+D+ ++ PK Q LD I D +
Sbjct: 90 KRSVKSKKGKAVEQSESEDSEDENEIDDEFEECVLLTLSPK-GQYQQALDITIAPEEDVQ 148
Query: 117 AVDDGKKDGEDRENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDVGDMKKSKKK 176
V G + TI T N V + SD+ + + +++
Sbjct: 149 FVVTG--------SYTISL---TGNYVK--HPFDNSSDSDEDEEDYYSDEESSNGEEEEE 195
Query: 177 KKGKEKETKSSSNEHSTDLDNAA-----------QDEPKMNMDEDLLTGNEQNQQQ---P 222
++ ++ E SS ++ DL +A+ +DE K N +D +E+++++ P
Sbjct: 196 EEEEDDEELSSGDDDLDDLVDASDIESRLDELVKKDEKKKNNKKDSKRKHEEDEEESAKP 255
Query: 223 DDKKAETTDKTLPSSQVGQGQDEKPKRKRK 252
+KK +TT K + +V ++ KPK K K
Sbjct: 256 AEKK-QTTKKDKKAEKVKDSEESKPKPKTK 284
>FKB4_SCHPO (O74191) FK506-binding protein 39 kDa (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase)
Length = 361
Score = 106 bits (265), Expect = 1e-22
Identities = 70/252 (27%), Positives = 119/252 (46%), Gaps = 17/252 (6%)
Query: 215 NEQNQQQPDDKKAETTDKTLPSSQVGQGQDEKPKRKRKERSKEKTLFAADDACISNVVNL 274
+E+ ++ +D T++ L + G + E+ + E+ + A + V
Sbjct: 127 DEEEEESDEDYDLSPTEEDLVETVSGDEESEEESESEDNSASEEDELDSAPAKKAQVKKK 186
Query: 275 PQGNEHSNQDTVNGSVDNGAQDNPDGNQSEDKKVKKKKKKSKSQGSEVVNSDVPVSAEQS 334
+E ++ + +N + +G ++KKV +K + P
Sbjct: 187 RTKDESEQEEAASPKKNNTKKQKVEGTPVKEKKVAFAEKLEQG----------PTGPAAK 236
Query: 335 SEMMKEDGNNVEDTKPSQVRTLSNGLVIQELETGKENGKIAAIGKKISINYTGKLKENGV 394
E + N K RTL G+V+ +++TG +G A GKK+ + Y GKL ENG
Sbjct: 237 KEKQQASSNAPSSPK---TRTLKGGVVVTDVKTG--SGASATNGKKVEMRYIGKL-ENGK 290
Query: 395 VVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPPNS 454
V + N PF F LG+GEVI GWD+G+ GM+ G +R++ +P M + + IP NS
Sbjct: 291 VFDKNTKGKPFAFILGRGEVIRGWDVGVAGMQEGGERKITIPAPM-AYGNQSIPGIPKNS 349
Query: 455 WLVYDFELVKVH 466
LV++ +LV+VH
Sbjct: 350 TLVFEVKLVRVH 361
>FKB3_YEAST (P38911) FK506-binding nuclear protein (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase) (Proline
rotamase) (Nucleolar proline isomerase) (FKBP-70)
Length = 411
Score = 103 bits (257), Expect = 9e-22
Identities = 92/348 (26%), Positives = 151/348 (42%), Gaps = 50/348 (14%)
Query: 156 DQLAVPSTVPDVGDMKKSKKKKKGKEKETKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGN 215
D++ S+ + + + KKK KGK+ E++S +E D D+ Q+ + + +
Sbjct: 74 DEIDEESSEEEEEEKTQKKKKSKGKKAESESEDDEEDDDEDDEFQESVLLTLSPEA---- 129
Query: 216 EQNQQQ------PDDKKAETTDKTLPSSQVG-------------QGQDEKPKRKRKERSK 256
Q QQ P+++ + S G +G+DE + S+
Sbjct: 130 -QYQQSLDLTITPEEEVQFIVTGSYAISLSGNYVKHPFDTPMGVEGEDEDEDADIYD-SE 187
Query: 257 EKTLFAADDACISN-----------VVNLPQGNEHSNQDTVNGSVDNGAQDNPDGNQSED 305
+ L +D I + V + + E +D N + ++ + + E
Sbjct: 188 DYDLTPDEDEIIGDDMDDLDDEEEEEVRIEEVQEEDEED--NDGEEEQEEEEEEEQKEEV 245
Query: 306 KKVKKKKKKSKSQGSEVVNSDVPVSAEQSSEMMK--EDGNNVEDTKPSQ------VRTLS 357
K KK KK K + E + + E K E+G +K Q + L
Sbjct: 246 KPEPKKSKKEKKRKHEEKEEEKKAKKVKKVEFKKDLEEGPTKPKSKKEQDKHKPKSKVLE 305
Query: 358 NGLVIQELETGKENGKIAAIGKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEG 417
G+VI++ G +G A G ++ + Y GKLK NG V + N PF F+LG+GEVI+G
Sbjct: 306 GGIVIEDRTIG--DGPQAKRGARVGMRYIGKLK-NGKVFDKNTSGKPFAFKLGRGEVIKG 362
Query: 418 WDIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPPNSWLVYDFELVKV 465
WDIG+ GM VG +RR+++P K IP NS L +D +LV +
Sbjct: 363 WDIGVAGMSVGGERRIIIPAPYAYGKQA-LPGIPANSELTFDVKLVSM 409
Score = 42.4 bits (98), Expect = 0.003
Identities = 58/255 (22%), Positives = 100/255 (38%), Gaps = 36/255 (14%)
Query: 5 FDKEAIDAGKKDSEDHENSIIETKLKTDNAFTESQIHSREAGPSDHLVDP--CTVPDVGD 62
FD++ ID + E+ E + + K K A +ES+ + D + T+
Sbjct: 71 FDEDEIDEESSEEEEEEKTQKKKKSKGKKAESESEDDEEDDDEDDEFQESVLLTLSPEAQ 130
Query: 63 IKKSKKKKKGKEKETKSSSNGD--------------STELDNAEQDEPKMNMAQDLLDQE 108
++S E+E + G T + +DE + D D +
Sbjct: 131 YQQSLDLTITPEEEVQFIVTGSYAISLSGNYVKHPFDTPMGVEGEDEDEDADIYDSEDYD 190
Query: 109 IVDNVDKEAVDD-GKKDGEDRENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDV 167
+ + D+ DD D E+ E + IE + D D + +E E ++ P
Sbjct: 191 LTPDEDEIIGDDMDDLDDEEEEEVRIEEVQEEDEEDNDGEEEQEEEEEEE-QKEEVKP-- 247
Query: 168 GDMKKSKKKKKGKEKETKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGNEQNQQQPDDKKA 227
+ KKSKK+KK K +E + + A+ K+ +DL E+ +P KK
Sbjct: 248 -EPKKSKKEKKRKHEEKEE---------EKKAKKVKKVEFKKDL----EEGPTKPKSKKE 293
Query: 228 ETTDKTLPSSQVGQG 242
+ DK P S+V +G
Sbjct: 294 Q--DKHKPKSKVLEG 306
>FKBH_SCHPO (Q10175) Probable peptidyl-prolyl cis-trans isomerase
C27F1.06c (EC 5.2.1.8) (PPIase) (Rotamase)
Length = 362
Score = 83.6 bits (205), Expect = 1e-15
Identities = 73/274 (26%), Positives = 126/274 (45%), Gaps = 36/274 (13%)
Query: 195 LDNAAQDEPKMNMDEDLLTGNEQNQQQPDDKKAETTDKTLPSSQVGQGQDEKPKRKRKER 254
+ N ++E +++ D L G ++ + E D ++ SS+ + ++E R +
Sbjct: 123 ITNIPEEEDSSDLENDFLYGADEFSSDEE----EMDDISVTSSE--EEEEENGARIEELN 176
Query: 255 SKEKTLFAADDACISNVVNLPQGNEHSNQDTVNGSVDNGAQDNPDGNQSEDKKVKKKKKK 314
S E+ A++ + V + E ++D + K ++K+KK
Sbjct: 177 SDEEDAEQAEEEILEKPVPKDEVAEKHSKDKL--------------------KKEEKEKK 216
Query: 315 SKSQGSEVVNSDVPVSAEQSSEMMKEDGNNVEDTKPSQVRTLSNGLVIQELETGKENGKI 374
+ S+ VN + E + T P QV L + +Q+ G +G
Sbjct: 217 TAVDVSDSVNGKKRKTEPAGEGEQTEKKSKSTKTYPKQV--LEGNVTVQDKVKG--DGPA 272
Query: 375 AAIGKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLV 434
A K++S+ Y G+L NG V + N PF F LG EVI+GWD+G+ GM+VG +R +
Sbjct: 273 AKRKKRVSMRYIGRLT-NGKVFDKNITGKPFTFNLGLEEVIKGWDVGIVGMQVGGERTIH 331
Query: 435 VPPSMT--SKKDGESENIPPNSWLVYDFELVKVH 466
+P +M SK+ IP NS LV+D +L+ V+
Sbjct: 332 IPAAMAYGSKR---LPGIPANSDLVFDVKLLAVN 362
>FKBP_NEIMB (P25138) FK506-binding protein (Peptidyl-prolyl
cis-trans isomerase) (PPIase) (EC 5.2.1.8) (Rotamase)
Length = 109
Score = 81.6 bits (200), Expect = 4e-15
Identities = 46/109 (42%), Positives = 68/109 (62%), Gaps = 4/109 (3%)
Query: 359 GLVIQELETGKENGKIAAIGKKISINYTGKLKENGVVVESNAGEA-PFKFRLGKGEVIEG 417
GL+I++L+ G GK A GK+I+++YTG L ENG +S+ P LG G+VI+G
Sbjct: 3 GLIIEDLQEGF--GKEAVKGKEITVHYTGWL-ENGTKFDSSLDRRQPLTITLGVGQVIKG 59
Query: 418 WDIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPPNSWLVYDFELVKVH 466
WD G GM+ G KR+L +P M G IPP++ L+++ EL+KV+
Sbjct: 60 WDEGFGGMKEGGKRKLTIPSEMGYGAHGAGGVIPPHATLIFEVELLKVY 108
>FKB2_YEAST (P32472) FK506-binding protein 2 precursor (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (FKBP-13) (FKBP-15)
Length = 135
Score = 81.6 bits (200), Expect = 4e-15
Identities = 42/89 (47%), Positives = 58/89 (64%), Gaps = 1/89 (1%)
Query: 378 GKKISINYTGKLKENGVVVESNAGE-APFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVP 436
G K+ ++YTG L E+G V +S+ +P F LG G VI+GWD G+ GM VGEKR+L +P
Sbjct: 43 GDKVKVHYTGSLLESGTVFDSSYSRGSPIAFELGVGRVIKGWDQGVAGMCVGEKRKLQIP 102
Query: 437 PSMTSKKDGESENIPPNSWLVYDFELVKV 465
S+ + G IPP++ LV+D ELV V
Sbjct: 103 SSLAYGERGVPGVIPPSADLVFDVELVDV 131
>FKBP_NEIMA (P56989) FK506-binding protein (Peptidyl-prolyl
cis-trans isomerase) (PPIase) (EC 5.2.1.8) (Rotamase)
Length = 109
Score = 79.0 bits (193), Expect = 2e-14
Identities = 45/108 (41%), Positives = 67/108 (61%), Gaps = 4/108 (3%)
Query: 360 LVIQELETGKENGKIAAIGKKISINYTGKLKENGVVVESNAGEA-PFKFRLGKGEVIEGW 418
L+I++L+ G GK A GK+I+++YTG L ENG +S+ P LG G+VI+GW
Sbjct: 4 LIIEDLQEGF--GKEAVKGKEITVHYTGWL-ENGTKFDSSLDRRQPLTITLGVGQVIKGW 60
Query: 419 DIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPPNSWLVYDFELVKVH 466
D G GM+ G KR+L +P M G IPP++ L+++ EL+KV+
Sbjct: 61 DEGFGGMKEGGKRKLTIPSEMGYGARGAGGVIPPHATLIFEVELLKVY 108
>ATRX_CAEEL (Q9U7E0) Transcriptional regulator ATRX homolog
(X-linked nuclear protein-1)
Length = 1359
Score = 78.2 bits (191), Expect = 4e-14
Identities = 93/407 (22%), Positives = 163/407 (39%), Gaps = 65/407 (15%)
Query: 7 KEAIDAGKKDSEDHENSIIETKLKTDNAFTESQIHSREAGPSDHLVDPCTVPDVGDIKKS 66
K + ++D +D E S ++ K+ +S+ S E+ + D KKS
Sbjct: 58 KRKASSSEEDDDDEEESPRKSSKKSRKR-AKSESESDESDEEE------------DRKKS 104
Query: 67 KKKKK----GKEKETKSSSNGDSTELDNAEQDEPKMNMAQDLLDQEIVDNVDKEAVDDGK 122
K KKK KEK K + S + D+ E+ E K K+ +
Sbjct: 105 KSKKKVDQKKKEKSKKKRTTSSSEDEDSDEEREQKSKKKSK--------KTKKQTSSESS 156
Query: 123 KDGEDRENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDVGDMKKSKKKKKGKEK 182
++ E+ + K K +V +T E++ D K SKK KKG +K
Sbjct: 157 EESEEERKVKKSKKNKEKSVKKRAETSEESDE--------------DEKPSKKSKKGLKK 202
Query: 183 ETKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGNEQNQQQPDDKKAETTDKTLPSSQVG-- 240
+ KS S S D + + K + + +E + P+ KK E ++ SS+
Sbjct: 203 KAKSESESESEDEKEVKKSKKKSK--KVVKKESESEDEAPEKKKTEKRKRSKTSSEESSE 260
Query: 241 --------QGQDEKPKRKRKERSKEKTLFAADDACISNVVNLPQGNEHSNQDTVNGSVDN 292
+ ++ PK K+K+ K L + +++ S+V LPQ + ++ S D
Sbjct: 261 SEKSDEEEEEKESSPKPKKKKPLAVKKLSSDEESEESDVEVLPQKKKRGAVTLISDSEDE 320
Query: 293 GAQDNPDGNQSEDKKVKKKK-KKSKSQGSEVVNSDVPVSAEQSSEMMKEDGNNVEDTKPS 351
Q + ++KV KKK KK +S S +S+ ++ + S+ + KP
Sbjct: 321 KDQKSESEASDVEEKVSKKKAKKQESSESGSDSSEGSITVNRKSK---------KKEKPE 371
Query: 352 QVRTLSNGLVIQELETGKENGKIAAIGKKISINYTGKLKE-NGVVVE 397
+ + G+++ + KE K+ K KE NG+V+E
Sbjct: 372 KKK---KGIIMDSSKLQKETIDAERAEKERRKRLEKKQKEFNGIVLE 415
Score = 48.1 bits (113), Expect = 5e-05
Identities = 43/235 (18%), Positives = 99/235 (41%), Gaps = 4/235 (1%)
Query: 124 DGEDRENITIETKLKTDNVVADIQTHREAEPSDQLAVPSTVPDVGDMKKSKKKKKGKEKE 183
DG E+ +E + +N + + + E ++ P +K+ ++ + E
Sbjct: 12 DGHVIEDEDLEMARQIENERKEKRAQKLKEKREREGKPPPKKRPAKKRKASSSEEDDDDE 71
Query: 184 TKSSSNEHSTDLDNAAQDEPKMNMDEDLLTGNEQNQQQPDDKKAETTDK--TLPSSQVGQ 241
+S A + DE+ +++++ D KK E + K T SS+
Sbjct: 72 EESPRKSSKKSRKRAKSESESDESDEEEDRKKSKSKKKVDQKKKEKSKKKRTTSSSEDED 131
Query: 242 GQDEKPKRKRKERSKEKTLFAADDACISNVVNLPQGNEHSNQDTVNGSVDNGAQDNPDGN 301
+E+ ++ +K+ K K +++ + S + ++ + + +V + + + D
Sbjct: 132 SDEEREQKSKKKSKKTKKQTSSESSEESEEERKVKKSKKNKEKSVKKRAETSEESDEDEK 191
Query: 302 QSEDKKVKKKKKKSKSQGSEVVN-SDVPVSAEQSSEMMKEDGNNVEDTKPSQVRT 355
S+ K KKK SE + +V S ++S +++K++ + ED P + +T
Sbjct: 192 PSKKSKKGLKKKAKSESESESEDEKEVKKSKKKSKKVVKKESES-EDEAPEKKKT 245
>FKB1_DROME (P48375) 12 kDa FK506-binding protein (FKBP)
(Peptidyl-prolyl cis-trans isomerase) (PPIase) (EC
5.2.1.8) (Macrolide binding protein)
Length = 108
Score = 77.0 bits (188), Expect = 9e-14
Identities = 37/88 (42%), Positives = 51/88 (57%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G+K++++YTG L + S PFKF +GKGEVI GWD G+ + VG+ +L+ P
Sbjct: 20 GQKVTVHYTGTLDDGTKFDSSRDRNKPFKFTIGKGEVIRGWDEGVAQLSVGQSAKLICSP 79
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKV 465
G IPPNS L +D EL+KV
Sbjct: 80 DYAYGSRGHPGVIPPNSTLTFDVELLKV 107
>FKB2_VICFA (Q41649) FK506-binding protein 2 precursor (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (15 kDa FKBP) (FKBP-15)
Length = 151
Score = 74.7 bits (182), Expect = 5e-13
Identities = 37/89 (41%), Positives = 53/89 (58%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G K+ ++Y GKL + V S +P F LG G+VI+GWD GL GM +GEKR+L +P
Sbjct: 49 GDKVKVHYRGKLTDGTVFDSSFERNSPIDFELGGGQVIKGWDQGLLGMCLGEKRKLKIPA 108
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKVH 466
+ + G IP + L++D ELV V+
Sbjct: 109 KLGYGEQGSPPTIPGGATLIFDTELVGVN 137
>FKBP_YEAST (P20081) FK506-binding protein 1 (FKBP) (Peptidyl-prolyl
cis-trans isomerase) (PPIase) (EC 5.2.1.8)
(Rapamycin-binding protein)
Length = 114
Score = 74.3 bits (181), Expect = 6e-13
Identities = 40/90 (44%), Positives = 57/90 (62%), Gaps = 2/90 (2%)
Query: 378 GKKISINYTGKLKENGVVVESNAGE-APFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVP 436
G ++I+YTG L ENG +S+ +PF+ +G G+VI+GWD+G+ + VGEK RL +P
Sbjct: 26 GDLVTIHYTGTL-ENGQKFDSSVDRGSPFQCNIGVGQVIKGWDVGIPKLSVGEKARLTIP 84
Query: 437 PSMTSKKDGESENIPPNSWLVYDFELVKVH 466
G IPPNS LV+D EL+KV+
Sbjct: 85 GPYAYGPRGFPGLIPPNSTLVFDVELLKVN 114
>FK22_ARATH (Q38936) FK506-binding protein 2-2 precursor (EC
5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (15 kDa FKBP) (FKBP-15-2)
Length = 163
Score = 74.3 bits (181), Expect = 6e-13
Identities = 37/89 (41%), Positives = 53/89 (58%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G I ++Y GKL + V S PF+F+LG G+VI+GWD GL G VGEKR+L +P
Sbjct: 52 GDTIKVHYRGKLTDGTVFDSSFERGDPFEFKLGSGQVIKGWDQGLLGACVGEKRKLKIPA 111
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKVH 466
+ + G IP + L++D EL+ V+
Sbjct: 112 KLGYGEQGSPPTIPGGATLIFDTELIAVN 140
>FKBY_HAEIN (P44760) Probable FKBP-type peptidyl-prolyl cis-trans
isomerase (EC 5.2.1.8) (PPIase) (Rotamase)
Length = 241
Score = 72.8 bits (177), Expect = 2e-12
Identities = 55/183 (30%), Positives = 91/183 (49%), Gaps = 10/183 (5%)
Query: 287 NGSVDNGAQDNPDGNQSEDKKVKKKKKKSKSQGSEVVNSDVPVSAEQSSEMMKEDGNN-- 344
N + +G +D +G K K +K + V S AE ++ KE+G+
Sbjct: 61 NARILDGLKDALEGKVDVRKDEKIQKTLESIEAKLVAASKA--KAESIAKQAKEEGDKFR 118
Query: 345 VEDTKPSQVRTLSNGLVIQELETGKENGKIAAIGKKISINYTGKLKENGVVVESNAGEA- 403
E K V+T +GL+ + GK G + ++YTGKL NG V +S+
Sbjct: 119 AEFAKGKDVKTTQSGLMYKIESAGK--GDTIKSTDTVKVHYTGKLP-NGKVFDSSVERGQ 175
Query: 404 PFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPPSMTSKKDGESENIPPNSWLVYDFELV 463
P +F+L +VI+GW GL+ ++ G K + V+ P + + G +IPPNS L++D E++
Sbjct: 176 PVEFQLD--QVIKGWTEGLQLVKKGGKIQFVIAPELGYGEQGAGASIPPNSTLIFDVEVL 233
Query: 464 KVH 466
V+
Sbjct: 234 DVN 236
>FKB2_MOUSE (P45878) FK506-binding protein 2 precursor (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (13 kDa FKBP) (FKBP-13)
Length = 140
Score = 72.4 bits (176), Expect = 2e-12
Identities = 37/88 (42%), Positives = 53/88 (60%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G + ++YTGKL++ S PF F LG G+VI+GWD GL GM GEKR+LV+P
Sbjct: 47 GDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPS 106
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKV 465
+ + G IP + LV++ EL+K+
Sbjct: 107 ELGYGERGAPPKIPGGATLVFEVELLKI 134
>FKB2_HUMAN (P26885) FK506-binding protein 2 precursor (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (13 kDa FKBP) (FKBP-13)
Length = 142
Score = 72.4 bits (176), Expect = 2e-12
Identities = 37/88 (42%), Positives = 53/88 (60%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G + ++YTGKL++ S PF F LG G+VI+GWD GL GM GEKR+LV+P
Sbjct: 49 GDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPS 108
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKV 465
+ + G IP + LV++ EL+K+
Sbjct: 109 ELGYGERGAPPKIPGGATLVFEVELLKI 136
>FK21_ARATH (Q38935) FK506-binding protein 2-1 precursor (EC
5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (15 kDa FKBP) (FKBP-15-1)
Length = 153
Score = 72.4 bits (176), Expect = 2e-12
Identities = 38/89 (42%), Positives = 51/89 (56%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G KI ++Y GKL + V S P +F LG G+VI GWD GL G VGEKR+L +P
Sbjct: 52 GDKIKVHYRGKLTDGTVFDSSFERGDPIEFELGTGQVIPGWDQGLLGACVGEKRKLKIPS 111
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKVH 466
+ +G IP + L++D ELV V+
Sbjct: 112 KLGYGDNGSPPKIPGGATLIFDTELVAVN 140
>FKB7_WHEAT (Q43207) 70 kDa peptidylprolyl isomerase (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase)
Length = 559
Score = 70.1 bits (170), Expect = 1e-11
Identities = 31/87 (35%), Positives = 51/87 (57%)
Query: 377 IGKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVP 436
+G ++ ++YTG L + S + FKF+LG+G+VI+GWD G++ M+ GE +P
Sbjct: 59 VGDEVEVHYTGTLLDGKKFDSSRDRDDTFKFKLGQGQVIKGWDQGIKTMKKGENALFTIP 118
Query: 437 PSMTSKKDGESENIPPNSWLVYDFELV 463
P + + G IP N+ L +D EL+
Sbjct: 119 PELAYGESGSPPTIPANATLQFDVELL 145
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/89 (32%), Positives = 49/89 (54%), Gaps = 3/89 (3%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEA-PFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVP 436
G +++ TGKL++ V ++ E PF+F+ + VIEG D + M+ GE + +P
Sbjct: 293 GAVVTVKITGKLQDGTVFLKKGHDEQEPFEFKTDEEAVIEGLDRAVLNMKKGEVALVTIP 352
Query: 437 PSMT--SKKDGESENIPPNSWLVYDFELV 463
P S + + +PPNS ++Y+ ELV
Sbjct: 353 PEYAYGSTESKQDAIVPPNSTVIYEVELV 381
Score = 37.0 bits (84), Expect = 0.11
Identities = 28/89 (31%), Positives = 42/89 (46%), Gaps = 9/89 (10%)
Query: 380 KISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPPS- 438
++ + Y +L E+G VV + G +F + G + ++ M+ GEK L V P
Sbjct: 178 EVFVKYEARL-EDGTVVSKSEG---VEFTVKDGHLCPALAKAVKTMKKGEKVLLAVKPQY 233
Query: 439 ----MTSKKDGESENIPPNSWLVYDFELV 463
M GE +PPN+ LV D ELV
Sbjct: 234 GFGEMGRPAAGEGGAVPPNASLVIDLELV 262
>FKB1_RAT (Q62658) FK506-binding protein 1A (EC 5.2.1.8)
(Peptidyl-prolyl cis-trans isomerase) (PPIase)
(Rotamase) (12 kDa FKBP) (FKBP-12) (Immunophilin FKBP12)
Length = 107
Score = 69.7 bits (169), Expect = 2e-11
Identities = 34/88 (38%), Positives = 51/88 (57%)
Query: 378 GKKISINYTGKLKENGVVVESNAGEAPFKFRLGKGEVIEGWDIGLEGMRVGEKRRLVVPP 437
G+ ++YTG L++ S PFKF LGK EVI GW+ G+ M VG++ +L++ P
Sbjct: 19 GQTCVVHYTGMLEDGKKFDSSRDRNKPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISP 78
Query: 438 SMTSKKDGESENIPPNSWLVYDFELVKV 465
G IPP++ LV+D EL+K+
Sbjct: 79 DYAYGATGHPGIIPPHATLVFDVELLKL 106
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.302 0.124 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,827,735
Number of Sequences: 164201
Number of extensions: 2671205
Number of successful extensions: 14817
Number of sequences better than 10.0: 1027
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 855
Number of HSP's that attempted gapping in prelim test: 10694
Number of HSP's gapped (non-prelim): 2907
length of query: 466
length of database: 59,974,054
effective HSP length: 114
effective length of query: 352
effective length of database: 41,255,140
effective search space: 14521809280
effective search space used: 14521809280
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 68 (30.8 bits)
Medicago: description of AC146527.7