BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146329.8 + phase: 0
(402 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
COXX_HUMAN (Q12887) Protoheme IX farnesyltransferase, mitochondr... 194 3e-49
COXX_YEAST (P21592) Protoheme IX farnesyltransferase, mitochondr... 157 6e-38
COXX_BRUSU (P67054) Protoheme IX farnesyltransferase (EC 2.5.1.-... 136 8e-32
COXX_BRUME (P67053) Protoheme IX farnesyltransferase (EC 2.5.1.-... 136 8e-32
COXX_AQUAE (O66544) Protoheme IX farnesyltransferase (EC 2.5.1.-... 132 2e-30
COXX_PARDE (P08301) Protoheme IX farnesyltransferase (EC 2.5.1.-... 117 7e-26
COXX_RHOSH (P56938) Protoheme IX farnesyltransferase (EC 2.5.1.-... 111 3e-24
COXX_BACPF (Q04444) Protoheme IX farnesyltransferase (EC 2.5.1.-... 107 4e-23
CTAO_BACSU (O31652) Protoheme IX farnesyltransferase (EC 2.5.1.-... 101 3e-21
CYOE_PSEPU (Q9WWR5) Protoheme IX farnesyltransferase (EC 2.5.1.-... 101 4e-21
COXX_BACSU (P24009) Protoheme IX farnesyltransferase (EC 2.5.1.-... 99 1e-20
CYOE_ECOLI (P18404) Protoheme IX farnesyltransferase (EC 2.5.1.-... 99 2e-20
COXX_RICPR (Q9ZDI2) Protoheme IX farnesyltransferase (EC 2.5.1.-... 98 3e-20
COXX_RICCN (Q92IF1) Protoheme IX farnesyltransferase (EC 2.5.1.-... 98 3e-20
CYOE_BUCAI (P57540) Protoheme IX farnesyltransferase (EC 2.5.1.-... 95 4e-19
CYOE_BUCAP (Q8K997) Protoheme IX farnesyltransferase (EC 2.5.1.-... 89 2e-17
CYOE_BUCBP (Q89AA7) Protoheme IX farnesyltransferase (EC 2.5.1.-... 65 4e-10
UBIA_PROST (O52366) 4-hydroxybenzoate octaprenyltransferase (EC ... 50 8e-06
COQ2_SCHPO (Q10252) Para-hydroxybenzoate--polyprenyltransferase,... 49 3e-05
UBIA_PASMU (P57970) 4-hydroxybenzoate octaprenyltransferase (EC ... 48 4e-05
>COXX_HUMAN (Q12887) Protoheme IX farnesyltransferase, mitochondrial
precursor (EC 2.5.1.-) (Heme O synthase)
Length = 443
Score = 194 bits (494), Expect = 3e-49
Identities = 109/277 (39%), Positives = 160/277 (57%), Gaps = 3/277 (1%)
Query: 60 SQLSKARLSLLVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDA 119
+QLSK +L+ LVV+T+ GF L G D T +GT + + +A+++NQ FE+ D+
Sbjct: 158 AQLSKIKLTALVVSTTAAGFALAPG-PFDWPCFLLTSVGTGLASCAANSINQFFEVPFDS 216
Query: 120 IMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTP 179
M RT RPL G+I+ AV +A+ + G A+L N L L N+ LY+ YTP
Sbjct: 217 NMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTP 276
Query: 180 LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCRED 239
LK+I NTWVGAVVGAIPP++GW AA+G + + +L LY WQ PHF AL++ RED
Sbjct: 277 LKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLRED 336
Query: 240 YAAGGFKMYSLADPSGRKTAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLESTALTLAISA 299
Y+ GG+ M S+ P VA+R+ + L+ L A +T+ F + + + IS
Sbjct: 337 YSRGGYCMMSVTHPG--LCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISY 394
Query: 300 AAFSFYRDRTKERARRMFHASLLYLPVFMAGLLIHRR 336
F FY D + +RR+F SL +LP+ + +L +R
Sbjct: 395 LGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKR 431
>COXX_YEAST (P21592) Protoheme IX farnesyltransferase, mitochondrial
precursor (EC 2.5.1.-) (Heme O synthase)
Length = 462
Score = 157 bits (396), Expect = 6e-38
Identities = 104/323 (32%), Positives = 167/323 (51%), Gaps = 24/323 (7%)
Query: 35 SSSPSVSASKSNDLISLARHYGNCYSQLSKARLSLLVVATSGTGFVLGSGGAVDLSMLSY 94
S PS + S+ ++ +L + Y QL+K RL++LV+ ++ + L A +L
Sbjct: 125 SKRPSHAISEGLNMKTLKKKVIMPYLQLTKPRLTILVMLSAICSYALSPYPASVNELLCL 184
Query: 95 TCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALL 154
T +GT + + SA+ +N E + D M RT RP+ G +T A +A+ +G G ++L
Sbjct: 185 T-VGTTLCSGSANAINMGREPEFDRQMVRTQARPVVRGDVTPTQAFEFAALIGTLGVSIL 243
Query: 155 ATQTNMLAAGLAASNLVLYSFVYTPLKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNS 214
N A L ASN+ LY + YT +K+ H +NTW+GA+VG +PPL+GWAAAS S
Sbjct: 244 YFGVNPTVAILGASNIALYGWAYTSMKRKHIINTWLGALVGMVPPLMGWAAASPLSHPGS 303
Query: 215 LILPAALYFWQIPHFMALAYMCREDYAAGGFKMYSLADPSGRKTAMVAMRNSIYLIPLGF 274
L L+ WQ PHF L++ R +Y G+ M + +P A V++R SI + PL F
Sbjct: 304 WCLAGLLFAWQFPHFNTLSHNIRNEYKNAGYVMTAWKNP--LLNARVSLRYSILMFPLCF 361
Query: 275 LAYDWGVTSGWFCLESTALTLAISAAAFSFY------------RDRTKER---------A 313
+ +T ++ ++S + ++ AF FY +D K A
Sbjct: 362 GLSYFNITDWYYQIDSGLINAWLTFWAFKFYWQQRINYSAKTLKDNVKFNKGLSVANIYA 421
Query: 314 RRMFHASLLYLPVFMAGLLIHRR 336
R+ F AS+L+LP + +IH++
Sbjct: 422 RKTFMASVLHLPAILILAIIHKK 444
>COXX_BRUSU (P67054) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 315
Score = 136 bits (343), Expect = 8e-32
Identities = 95/300 (31%), Positives = 149/300 (49%), Gaps = 11/300 (3%)
Query: 45 SNDLISLARHYGNCYSQLSKARLSLLVVATSGTGFVLGSGGAVD-LSMLSYTCLGTMMVA 103
S D +L+ Y L K R+ LVV T G VL G L+++S C+ + A
Sbjct: 10 SEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIA--VGA 67
Query: 104 ASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAA 163
++ LN ++ DA+M+RT +RP+P+G I + + ++ L N LAA
Sbjct: 68 GASGALNMWYDADIDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAA 127
Query: 164 GLAASNLVLYSFVYTP-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALY 222
L A + Y+ +YT LK+ P N +G GA PP++GWAAA+G+I+ +SL+L ++
Sbjct: 128 ALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAAATGEITWDSLVLFMIIF 187
Query: 223 FWQIPHFMALAYMCREDYAAGGFKMYSLADPSGR-KTAMVAMRNSIYLIPLGFLAYDWGV 281
W PHF AL+ DY A M + + G T A+ ++ + P+G L + G
Sbjct: 188 LWTPPHFWALSLFTTNDYEAARIPM--MPNVKGELSTRRQALFYAVLMAPVGVLPWVMGF 245
Query: 282 TSGWFCLESTALTLAISAAAFSFYRDRTKER----ARRMFHASLLYLPVFMAGLLIHRRT 337
++ + ST L LA A+ + ++ + AR++F SLLYL A LL T
Sbjct: 246 AGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLLFEALT 305
>COXX_BRUME (P67053) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 315
Score = 136 bits (343), Expect = 8e-32
Identities = 95/300 (31%), Positives = 149/300 (49%), Gaps = 11/300 (3%)
Query: 45 SNDLISLARHYGNCYSQLSKARLSLLVVATSGTGFVLGSGGAVD-LSMLSYTCLGTMMVA 103
S D +L+ Y L K R+ LVV T G VL G L+++S C+ + A
Sbjct: 10 SEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIA--VGA 67
Query: 104 ASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAA 163
++ LN ++ DA+M+RT +RP+P+G I + + ++ L N LAA
Sbjct: 68 GASGALNMWYDADIDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAA 127
Query: 164 GLAASNLVLYSFVYTP-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALY 222
L A + Y+ +YT LK+ P N +G GA PP++GWAAA+G+I+ +SL+L ++
Sbjct: 128 ALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAAATGEITWDSLVLFMIIF 187
Query: 223 FWQIPHFMALAYMCREDYAAGGFKMYSLADPSGR-KTAMVAMRNSIYLIPLGFLAYDWGV 281
W PHF AL+ DY A M + + G T A+ ++ + P+G L + G
Sbjct: 188 LWTPPHFWALSLFTTNDYEAARIPM--MPNVKGELSTRRQALFYAVLMAPVGVLPWVMGF 245
Query: 282 TSGWFCLESTALTLAISAAAFSFYRDRTKER----ARRMFHASLLYLPVFMAGLLIHRRT 337
++ + ST L LA A+ + ++ + AR++F SLLYL A LL T
Sbjct: 246 AGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLLFEALT 305
>COXX_AQUAE (O66544) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 292
Score = 132 bits (332), Expect = 2e-30
Identities = 83/282 (29%), Positives = 143/282 (50%), Gaps = 15/282 (5%)
Query: 59 YSQLSKARLSLLVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKND 118
Y L+K + LV+ T+ G LGS G + ++ +T LGT + AA ++ LN V + D
Sbjct: 15 YLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAAGSAVLNMVIDKDID 74
Query: 119 AIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAA----SNLVLYS 174
+M RTS+RPLP G + A + ++ + ++ T +L A L A S ++LYS
Sbjct: 75 KLMVRTSERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPALLVALASFSYVILYS 134
Query: 175 FVYTPLKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAY 234
+ LK+ PV T +G + GA+PP++G+ AASG + +N++ L ++ WQ PHF LA
Sbjct: 135 LL---LKRKSPVATEIGGISGALPPVIGYVAASGSVDINAIALFLLMFMWQPPHFWVLAL 191
Query: 235 MCREDYAAGGFKMYSLADPSGRKTAMVAMRNSIY---LIPLGFLAYDWGVTSGWFCLEST 291
+DY G P R + ++ +Y L P+ + Y G+ + + +
Sbjct: 192 KYADDYKRAGIPTL----PVARGVFITKLKTLLYTASLFPVSLIPYLTGLVENLYFVVAV 247
Query: 292 ALTLAISAAAFSFYRDRTKERARRMFHASLLYLPVFMAGLLI 333
+ L F+ + KE + ++F S++YL V +++
Sbjct: 248 VMNLIYLGLTLKFFFSK-KEESMKLFFFSIIYLAVLFGTMIV 288
>COXX_PARDE (P08301) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 298
Score = 117 bits (292), Expect = 7e-26
Identities = 94/290 (32%), Positives = 137/290 (46%), Gaps = 24/290 (8%)
Query: 59 YSQLSKARLSLLVVATSGTGFVLGSGGA---VDLSMLSYTCLGTMMVAASASTLNQVFEI 115
Y L K R+ LVV T+ G + V + + LG ++ LN ++
Sbjct: 11 YVALLKPRVMSLVVFTAFVGLWIAPQPVNPFVAFCAVLFIALG----GGASGALNMWYDA 66
Query: 116 KNDAIMRRTSQRPLPSGRITV--PHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLY 173
DA+MRRT+ RP+PSGR+T P AVG A S GL+ +L N AAG A + Y
Sbjct: 67 DIDAVMRRTAGRPVPSGRVTSQEPLAVGIALS-GLS-VMMLGAGGNWFAAGFLAFTIFFY 124
Query: 174 SFVYTP-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMAL 232
+ VYT LK+ P N +G GA PP++GWA +G I + SL++ A ++FW PHF AL
Sbjct: 125 AVVYTIWLKRSTPQNIVIGGAAGAFPPMIGWALPTGGIGIESLLMFALIFFWTPPHFWAL 184
Query: 233 AYMCREDYAAGGFKMYSLADPSGRK-TAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLEST 291
A ++DY+ G M ++ GRK T ++ L P V + S
Sbjct: 185 ALFMKDDYSKAGVPMLTVT--HGRKVTRCHIFAYTLVLAPFALWLGFTSVGGPLYLAVSV 242
Query: 292 ALTLAISAAAFSFYRDRTKERA--------RRMFHASLLYLPVFMAGLLI 333
L A + R R++++A +R F SL Y + LL+
Sbjct: 243 VLNALFIAGGWQILR-RSEDQAQADGYRVEKRYFRLSLYYTFLHFLALLV 291
>COXX_RHOSH (P56938) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 284
Score = 111 bits (278), Expect = 3e-24
Identities = 78/240 (32%), Positives = 116/240 (47%), Gaps = 13/240 (5%)
Query: 103 AASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLA 162
A ++ LN D +M+RT RP+PSG + A+G ++ +L TN+ A
Sbjct: 35 AGASGALNMWSHEDIDRVMKRTRNRPVPSGTVAPGEALGIGLALSGIAVVMLGLATNLFA 94
Query: 163 AGLAASNLVLYSFVYTP-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAAL 221
AGL A + Y+ VY+ LK+ P N +G GA PP++GWA A+G +S+ SL + A +
Sbjct: 95 AGLLAFTIFFYAVVYSMWLKRTTPQNIVIGGAAGAFPPMIGWAVATGGVSVESLFMFALI 154
Query: 222 YFWQIPHFMALAYMCREDYAAGGFKMYSLADPSGRKTAMVAMRNSIYLIPLGFLAYDWGV 281
+ W PHF +LA + DY+ G M ++ R T + S+ L PL G
Sbjct: 155 FMWTPPHFWSLALFMKSDYSDAGVPMLTVTH-GRRVTRAHVLVYSLLLAPLAVAGAFTG- 212
Query: 282 TSGWFCLESTALTL---AISAAAFSFYRDRTKERARR------MFHASLLYLPVFMAGLL 332
T G L +TAL L + A ++ RD + A R F SL YL + +L
Sbjct: 213 TGGPLYL-ATALALNGWLLVGAVRTWRRDEAQAEADRYRVEKAFFRFSLYYLFLHFGAIL 271
>COXX_BACPF (Q04444) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 312
Score = 107 bits (268), Expect = 4e-23
Identities = 87/271 (32%), Positives = 128/271 (47%), Gaps = 20/271 (7%)
Query: 70 LVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPL 129
L + +GT F + L + + LG +V A TLN + D +M RT +RP
Sbjct: 55 LAIVYTGTVFTM------HLDTMIFALLGAALVMAGGCTLNNYIDRDIDHLMERTKERPT 108
Query: 130 PSGRITVPHAVGWASSVGLAGTAL---LATQTNMLAAGLAASNLVLYSFVYTP-LKQIHP 185
+GR + H + VGLA AL T AA + L +Y +YT K+
Sbjct: 109 VTGRFSAKHVL----LVGLAQAALGIIFLALTTPTAAVIGLIGLFIYVVLYTMWTKRTTT 164
Query: 186 VNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCREDYAAGGF 245
+NT VG+ GA+PPL+GWAA G + L + +L ++ WQ PHF+ALA E+Y A G
Sbjct: 165 LNTIVGSFSGAVPPLIGWAAIDGGLHLYAWLLFFIMFLWQPPHFLALAMKRVEEYRAAGI 224
Query: 246 KMYS-LADPSGRKTAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLESTALTLAISAAAFSF 304
M +A K MV + L+P+ + Y +G+ LA+ A F
Sbjct: 225 PMLPVVAGFEMTKRQMVVYVAA--LLPVSLMLYPFGLVYTIVAAVLGVGWLALGIAGFKM 282
Query: 305 YRDRTKERARRMFHASLLYLPV-FMAGLLIH 334
D + AR MF SL YL + F+ +++H
Sbjct: 283 KDD--IKWARLMFVYSLNYLTILFVLMVIVH 311
>CTAO_BACSU (O31652) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 329
Score = 101 bits (252), Expect = 3e-21
Identities = 73/244 (29%), Positives = 121/244 (48%), Gaps = 7/244 (2%)
Query: 85 GAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAVGWAS 144
G L + LGT V AS + N F+ DA M RT R +G++ + + S
Sbjct: 69 GLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMDAKMARTRSRASVTGKMPPAMILTYGS 128
Query: 145 SVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTP-LKQIHPVNTWVGAVVGAIPPLLGW 203
+G+AG A+L + N L A L + + Y+ +YT +K+ +T+VG+ GA PPL+G+
Sbjct: 129 VLGIAGLAMLYS-LNPLTAFLGLAAFIFYAIIYTVWVKRTSVWSTFVGSFPGAAPPLMGY 187
Query: 204 AAASGDISLNSLILPAALYFWQIPHFMALAYMCREDYAAGGFKMYSLADPSGRKTAMVAM 263
A +GD S+ +++L ++ WQ PHF A+ +E+Y A G + + T + M
Sbjct: 188 CAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAGVPLLPVV-KGNHVTKIKMM 246
Query: 264 RNSIYLIPLGFL---AYDWGVTSGWFCLESTAL-TLAISAAAFSFYRDRTKERARRMFHA 319
+ L+P+ L + G S ++ L + L + I + F D + A+ MF
Sbjct: 247 QYIAVLVPVTLLFPFSLGTGHISPFYFLAALVLGGIWIKKSIKGFKTDDDVKWAKDMFVY 306
Query: 320 SLLY 323
SL+Y
Sbjct: 307 SLIY 310
>CYOE_PSEPU (Q9WWR5) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 295
Score = 101 bits (251), Expect = 4e-21
Identities = 73/248 (29%), Positives = 118/248 (47%), Gaps = 11/248 (4%)
Query: 59 YSQLSKARLSLLVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKND 118
+ Q++K + V + GF L S G VD ++ +GT +V AS N + D
Sbjct: 6 FIQITKPGIIFGNVLSVAGGFFLASKGHVDFALFLAVVIGTSLVVASGCVFNNCIDRDID 65
Query: 119 AIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYT 178
M RT R + G +++P A+ +A+ +G+AG +LL Q N L+A A ++Y Y+
Sbjct: 66 HKMERTKNRVMVQGGMSLPLALIYATLLGVAGFSLLYVQANPLSAFCALIGFIVYVGFYS 125
Query: 179 P-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCR 237
LK+ T VG++ GA+PP++G+ A S L ++ L WQ+PH A+A
Sbjct: 126 LWLKRKSVHGTLVGSLSGAMPPVIGYCAVSNSFDLAAVTLLVMFSLWQMPHSFAIAIFRF 185
Query: 238 EDYAAGGFKMYSLADPSGRKTAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLESTALTLAI 297
+DY+A + +A ++A + I L L F+ +T G + L
Sbjct: 186 KDYSAANIPVLPVA------RGILAAKKQIVLYVLAFVLATLMLTLGGY----AGLGYLA 235
Query: 298 SAAAFSFY 305
AAA Y
Sbjct: 236 VAAAMGLY 243
>COXX_BACSU (P24009) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 305
Score = 99.4 bits (246), Expect = 1e-20
Identities = 71/260 (27%), Positives = 120/260 (45%), Gaps = 31/260 (11%)
Query: 88 DLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAVGWASSVG 147
+++ + T +G+ ++ A + +N ++ D +M RT RP +G+I A+ W+ +
Sbjct: 59 NINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVTGKIQPSQAL-WSGILL 117
Query: 148 LAGTALLATQTNMLAAGLAASNLVLYSFVYTP-LKQIHPVNTWVGAVVGAIPPLLGWAAA 206
+A ++ T ++AA + + Y +YT K+ + +NT VG+V GA+PPL+GW A
Sbjct: 118 VALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTVVGSVSGAVPPLIGWTAV 177
Query: 207 SGDISLNSLILPAALYFWQIPHFMALAYMCREDYAAGGFKM----YSLADPSGRKTAMVA 262
G+I + + +L L+ WQIPHF+ALA EDY A M Y + VA
Sbjct: 178 EGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPMLPVVYGFEVTKRQIIVWVA 237
Query: 263 MRNSIYLIPLGFLAYDWG---------VTSGWFCLESTALTLAISAAAFSFYRDRTKERA 313
L+PL F G + GW L F + A
Sbjct: 238 C-----LMPLPFFLGSLGLPIVILGLLLNIGWLIL-----------GLMGFRSKNIMKWA 281
Query: 314 RRMFHASLLYLPVFMAGLLI 333
+MF SL Y+ ++ +++
Sbjct: 282 TQMFVYSLNYMTIYFVAMVV 301
>CYOE_ECOLI (P18404) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 296
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/166 (34%), Positives = 87/166 (51%), Gaps = 1/166 (0%)
Query: 78 GFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVP 137
GF+L S G++D + YT +G +V AS N + D M RT R L G I+
Sbjct: 25 GFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPA 84
Query: 138 HAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTPLKQIHPV-NTWVGAVVGA 196
++ +A+ +G+AG LL N LA L V+Y VY+ + H V T +G++ GA
Sbjct: 85 VSLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGA 144
Query: 197 IPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCREDYAA 242
PP++G+ A +G+ + IL A WQ+PH A+A +DY A
Sbjct: 145 APPVIGYCAVTGEFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQA 190
>COXX_RICPR (Q9ZDI2) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 310
Score = 98.2 bits (243), Expect = 3e-20
Identities = 78/269 (28%), Positives = 123/269 (44%), Gaps = 6/269 (2%)
Query: 59 YSQLSKARLSLLVVATSGTGFVLGSGGAVDL-SMLSYTCLGTMMVAASASTLNQVFEIKN 117
Y L K R+ LV+ T G L L + ++ C+ + A SA +N ++
Sbjct: 23 YILLMKPRVMSLVIFTGFVGMWLAPDSIHPLIAGIAVICIA--LGAGSAGAMNMWYDRDI 80
Query: 118 DAIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVY 177
D +M+RT RP+ G I A+ + G +A N+LA+ L + Y +Y
Sbjct: 81 DILMKRTQNRPIVRGVIEPDEALSFGLITGFFAVFFMALCVNILASFLLLFTIFYYICIY 140
Query: 178 TP-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMC 236
T LK+ N +G V GA+PP++G AA S ISL S+IL ++ W PH A+A C
Sbjct: 141 TIWLKRRSIQNIVIGGVSGALPPVIGHAAVSNTISLESIILFLIIFIWTPPHSWAIALFC 200
Query: 237 REDYAAGGFKMYSLADPSGRKTAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLESTALTLA 296
+DY M + + T + SI L + + + G+ + + + + L
Sbjct: 201 NDDYKHCKIPMMPVVKGT-LYTKKQILIYSIILFIVSLMPFFIGMNNDIYLIIVCIIGLV 259
Query: 297 ISAAAFS-FYRDRTKERARRMFHASLLYL 324
AFS FY ++A+R F S+ YL
Sbjct: 260 FLYYAFSLFYDTPDNKQAKRFFTYSIFYL 288
>COXX_RICCN (Q92IF1) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 305
Score = 98.2 bits (243), Expect = 3e-20
Identities = 82/279 (29%), Positives = 130/279 (46%), Gaps = 8/279 (2%)
Query: 59 YSQLSKARLSLLVVATSGTGFVLGSGGAVD-LSMLSYTCLGTMMVAASASTLNQVFEIKN 117
Y L K R+ LV+ T G L ++ ++ C+ + A SA +N ++
Sbjct: 23 YILLMKPRVMSLVIFTGFVGMWLAPYSVHPFIAGIAVVCIA--LGAGSAGAINMWYDRDI 80
Query: 118 DAIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVY 177
D++M+RT +RP+ G I A+ + G +A N+LA+ L + Y +Y
Sbjct: 81 DSLMKRTQKRPIVRGVIESDEALSFGLITGFFAVFFMALCVNLLASFLLLFTIFYYICIY 140
Query: 178 TP-LKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMC 236
T LK+ N +G V GA+PP++G+AA S ISL S+IL ++ W PH ALA C
Sbjct: 141 TIWLKRRSIQNIVIGGVSGALPPVIGYAAVSNTISLESIILFLIIFIWTPPHSWALALFC 200
Query: 237 REDYAAGGFKMYSLADPSGRKTAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLESTALTLA 296
+DY M A T + SI L + + + G+ + + + S L +
Sbjct: 201 NDDYKNCKVPMMP-AVKGTLYTKKQILIYSILLFIVSLMPFFIGMNNFIYLIISGILGVV 259
Query: 297 ISAAAFS-FYRDRTKERARRMFHASLLYLPVFMAGLLIH 334
A S FY ++A+R F S+ YL F LL++
Sbjct: 260 FLYYAGSLFYDTPDNKQAKRFFAYSIFYL--FFIFLLLY 296
>CYOE_BUCAI (P57540) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 285
Score = 94.7 bits (234), Expect = 4e-19
Identities = 68/256 (26%), Positives = 125/256 (48%), Gaps = 10/256 (3%)
Query: 78 GFVLGSG-GAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITV 136
GF+ S A + + YT LG +V ASA N + +I D M+RTS R L + V
Sbjct: 24 GFLFASRHAAFNYVLFIYTILGASLVIASACVFNNLIDIDIDKKMKRTSNRVLSKKLLPV 83
Query: 137 PHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTPL-KQIHPVNTWVGAVVG 195
+A +G+ G ++L N ++ LA +Y +YT K+ +T++G+ G
Sbjct: 84 FSVFNFAIFLGVLGLSILGCLVNFISMSLAVFGFFIYVVLYTMFYKRRSFYSTFIGSFSG 143
Query: 196 AIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCREDYAAGGFKMYSLADPSG 255
+ P ++G+ A S I + S++L + FWQ+ HF +++ M +DY ++S+
Sbjct: 144 STPSVIGYTAVSNTIDICSILLFVIVIFWQMSHFYSISIMRIKDYREAKIPVFSVV---- 199
Query: 256 RKTAMVAMRNSIYLIPLGFLAYDW---GVTSGWFCLESTALTLAISAAAFS-FYRDRTKE 311
+ A+ Y++ F + + G S F L S+ + S ++S ++ K+
Sbjct: 200 KGVAITKKHIFFYVLNFSFFSSLFTFLGYLSYNFLLLSSIVNFYWSFLSYSNIKKNNDKK 259
Query: 312 RARRMFHASLLYLPVF 327
AR++F+ S++ + F
Sbjct: 260 NARKLFYFSIIVIVFF 275
>CYOE_BUCAP (Q8K997) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 284
Score = 89.4 bits (220), Expect = 2e-17
Identities = 57/183 (31%), Positives = 93/183 (50%), Gaps = 1/183 (0%)
Query: 59 YSQLSKARLSLLVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKND 118
Y +++K R+ + + F+ S ++ + +T LGT +V AS+ N + +I D
Sbjct: 5 YLEITKPRIIIGNIILIIGSFLFSSFPFFNVFLFFFTILGTSLVIASSCIFNNLIDIDID 64
Query: 119 AIMRRTSQRPLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYT 178
M RT R L I+ A +AS +G+ G +L N+L+ L+ V+Y F YT
Sbjct: 65 TKMNRTKNRVLVKNLISPTSASIFASFIGIVGFFILGLFVNILSMFLSFIGFVIYVFFYT 124
Query: 179 -PLKQIHPVNTWVGAVVGAIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCR 237
LK+ +T++G+ G+IP ++G A S I L +L FWQ+ HF A+A +
Sbjct: 125 FFLKRKSMYSTFIGSFSGSIPSVIGHTAISNSIDLFCFLLFIIFIFWQMSHFYAIAILYI 184
Query: 238 EDY 240
DY
Sbjct: 185 NDY 187
>CYOE_BUCBP (Q89AA7) Protoheme IX farnesyltransferase (EC 2.5.1.-)
(Heme O synthase)
Length = 288
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/172 (26%), Positives = 77/172 (44%), Gaps = 1/172 (0%)
Query: 78 GFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVP 137
G+ + + G + +L L ++ SA LN V + D IM RT R L
Sbjct: 29 GYGVAARGHIYSKLLFLDSLSLFLIVGSACVLNNVIDCDIDKIMLRTQCRLLVKYNKFCK 88
Query: 138 HAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTP-LKQIHPVNTWVGAVVGA 196
A+ A + G L N++ L + Y F+Y+ LK+ ++T VG++ G+
Sbjct: 89 LAILIAMFMLFLGLILCVKFINVVCFCLFLLGWLTYIFLYSFFLKKTSAISTIVGSISGS 148
Query: 197 IPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCREDYAAGGFKMY 248
+PP++G+ + + + SL L WQIPH A+ + DY ++
Sbjct: 149 LPPIVGYCSVTNNFDFCSLNLLIMFALWQIPHSYAICILHFRDYKIANIPVF 200
>UBIA_PROST (O52366) 4-hydroxybenzoate octaprenyltransferase (EC
2.5.1.-) (4-HB polyprenyltransferase)
Length = 288
Score = 50.4 bits (119), Expect = 8e-06
Identities = 54/203 (26%), Positives = 94/203 (45%), Gaps = 11/203 (5%)
Query: 50 SLARHYGNCYSQLSKARL---SLLVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASA 106
S+A + YS+L + SLL++ + + + L +L G ++ A+
Sbjct: 4 SMALSKWHAYSRLMRIDRPIGSLLLLWPTYWALWIAAQSIPSLHILIVFTAGVFLMRAAG 63
Query: 107 STLNQVFEIKNDAIMRRTSQRPLPSGRITVPHA-VGWASSVGLAGTALLATQTNMLAAGL 165
+N + D + RT RPLPSG +T A + +AS VGL + LL N + L
Sbjct: 64 CVINDFADRHFDGHVERTKHRPLPSGDVTEKEAKILFASLVGL--SFLLVLTLNSMTIWL 121
Query: 166 AASNLVLYSFVYTPLKQI-HPVNTWVGAVVG-AIPPLLGWAAASGDISLNSLILPAALYF 223
+ + L L +++Y +K++ H + +GA G +IP +G++A S + L +L
Sbjct: 122 SVAGLAL-AWIYPFVKRVSHLLQVVLGAAFGWSIP--MGFSAVSESLPLVCWVLFLVNIL 178
Query: 224 WQIPHFMALAYMCREDYAAGGFK 246
W + + A + R D G K
Sbjct: 179 WSVIYDTQYAMVDRNDDLKIGVK 201
>COQ2_SCHPO (Q10252) Para-hydroxybenzoate--polyprenyltransferase,
mitochondrial precursor (EC 2.5.1.-)
(PHB:polyprenyltransferase) (P-hydroxybenzoate
polyprenyl diphosphate transferase)
Length = 358
Score = 48.5 bits (114), Expect = 3e-05
Identities = 51/202 (25%), Positives = 100/202 (49%), Gaps = 17/202 (8%)
Query: 32 STFSSSPS-VSASKSN--DLISLARHYGNCYSQLSKAR--LSLLVVATSGTGFVLGSGGA 86
S+ S +P+ +S SK + DL S Y Y+++S+A ++ + T +L + A
Sbjct: 39 SSNSVTPNLISPSKKSWKDLFSKRWQY---YAEISRAGSPTGTYLLYSPCTWSILMAAYA 95
Query: 87 VDLSMLSYTCL------GTMMVAASASTLNQVFEIKNDAIMRRTSQRPLPSGRITVPHAV 140
D S+++ T + G+ ++ ++ +N +++ + DA + R+ RPL SG+++V A+
Sbjct: 96 YDSSLVNVTKMLALFGVGSFLMRSAGCVINDLWDRELDAKVERSKSRPLASGKLSVRQAI 155
Query: 141 GWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTPLKQIHPVNTWVGAVVGAIPPL 200
SV L + + Q N L ++LV +Y +K+I V + +
Sbjct: 156 S-LLSVQLTASLGILLQLNPYTIKLGVASLVPVC-IYPAMKRITYYPQVVLGLTFGYGAV 213
Query: 201 LGWAAASGDISLN-SLILPAAL 221
+GW A +G+ +N S++ P L
Sbjct: 214 MGWPALAGEACMNWSVVAPLYL 235
>UBIA_PASMU (P57970) 4-hydroxybenzoate octaprenyltransferase (EC
2.5.1.-) (4-HB polyprenyltransferase)
Length = 290
Score = 48.1 bits (113), Expect = 4e-05
Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 9/252 (3%)
Query: 68 SLLVVATSGTGFVLGSGGAVDLSMLSYTCLGTMMVAASASTLNQVFEIKNDAIMRRTSQR 127
+LL++ + L G DLS+LS LG + + A+ +N + D ++RTS+R
Sbjct: 23 TLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAAGCVINDYADRHIDGAVKRTSKR 82
Query: 128 PLPSGRITVPHAVGWASSVGLAGTALLATQTNMLAAGLAASNLVLYSFVYTPLKQ-IHPV 186
PL +G T P W + + + +L N A L+ V +F+Y +K+ H
Sbjct: 83 PLATGAAT-PEEAKWLFVLLVFCSFILVLFLNTYAIVLSFI-AVFLAFIYPFMKRYTHLP 140
Query: 187 NTWVGAVVG-AIPPLLGWAAASGDISLNSLILPAALYFWQIPHFMALAYMCREDYAAGGF 245
++G G +IP + + A+ + L +L A W + + A + R+D G
Sbjct: 141 QLFLGMAFGWSIP--MAYGASIEALPLECWLLFFANLAWTVAYDTQYAMVDRDDDLRIGV 198
Query: 246 KMYSLADPSGRKTAMVAMRNSIYLIPLGFLAYDWGVTSGWFCLESTALTLAISAAAFSFY 305
K ++ + ++++ + L LG + Y + + +F + A L +
Sbjct: 199 KSTAILF-AQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVVLFLATLLFVYQC--KLI 255
Query: 306 RDRTKERARRMF 317
+DR +E + F
Sbjct: 256 KDRERESCFKAF 267
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,326,759
Number of Sequences: 164201
Number of extensions: 1682884
Number of successful extensions: 5245
Number of sequences better than 10.0: 37
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 5113
Number of HSP's gapped (non-prelim): 64
length of query: 402
length of database: 59,974,054
effective HSP length: 112
effective length of query: 290
effective length of database: 41,583,542
effective search space: 12059227180
effective search space used: 12059227180
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Medicago: description of AC146329.8