BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146329.5 + phase: 0
(639 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
FTHS_SPIOL (P28723) Formate--tetrahydrofolate ligase (EC 6.3.4.3... 1153 0.0
C1TC_HUMAN (P11586) C-1-tetrahydrofolate synthase, cytoplasmic (... 845 0.0
C1TC_MOUSE (Q922D8) C-1-tetrahydrofolate synthase, cytoplasmic (... 835 0.0
C1TC_RAT (P27653) C-1-tetrahydrofolate synthase, cytoplasmic (C1... 834 0.0
C1TC_SPOFR (Q27772) C-1-tetrahydrofolate synthase, cytoplasmic (... 744 0.0
C1TC_DROME (O96553) C-1-tetrahydrofolate synthase, cytoplasmic (... 729 0.0
C1TC_YEAST (P07245) C-1-tetrahydrofolate synthase, cytoplasmic (... 710 0.0
C1TM_YEAST (P09440) C-1-tetrahydrofolate synthase, mitochondrial... 676 0.0
FTHS_MOOTH (P21164) Formate--tetrahydrofolate ligase (EC 6.3.4.3... 515 e-145
FTHS_CLOCY (Q07064) Formate--tetrahydrofolate ligase (EC 6.3.4.3... 512 e-144
FTHS_CLOAC (P13419) Formate--tetrahydrofolate ligase (EC 6.3.4.3... 506 e-143
FTHS_STRMU (Q59925) Formate--tetrahydrofolate ligase (EC 6.3.4.3... 461 e-129
SPEN_DROME (Q8SX83) Split ends protein 41 0.008
VG13_BPML5 (Q05219) Gene 13 protein (GP13) 33 3.0
PDXA_SPHAR (O85987) 4-hydroxythreonine-4-phosphate dehydrogenase... 33 3.0
MURA_DESTE (Q9ZH21) UDP-N-acetylglucosamine 1-carboxyvinyltransf... 33 3.0
PYRG_PYRHO (O59456) CTP synthase (EC 6.3.4.2) (UTP--ammonia liga... 32 3.9
GUN_BACSZ (P29019) Endoglucanase precursor (EC 3.2.1.4) (Endo-1,... 32 3.9
DHE2_CLOSY (P24295) NAD-specific glutamate dehydrogenase (EC 1.4... 32 3.9
SDHB_BACSU (O34635) Probable L-serine dehydratase, beta chain (E... 32 5.1
>FTHS_SPIOL (P28723) Formate--tetrahydrofolate ligase (EC 6.3.4.3)
(Formyltetrahydrofolate synthetase) (FHS) (FTHFS)
Length = 636
Score = 1153 bits (2982), Expect = 0.0
Identities = 563/634 (88%), Positives = 609/634 (95%)
Query: 6 SSSVMRKLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDE 65
SS +RKL+V +PVP+DIDIAN+V+P+HI++IA LNL+P HYDLYGKYKAKVLLS LDE
Sbjct: 3 SSKTVRKLEVATPVPADIDIANAVEPLHIADIAADLNLSPRHYDLYGKYKAKVLLSVLDE 62
Query: 66 LQESKDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKG 125
+QE++DGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTC+RQPSQGPTFGIKG
Sbjct: 63 VQETQDGYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCLRQPSQGPTFGIKG 122
Query: 126 GAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPP 185
GAAGGGYSQVIPMDEFNLHLTGDIHAITA+NNLLAAAIDTR+FHESTQSDKALFNRLCPP
Sbjct: 123 GAAGGGYSQVIPMDEFNLHLTGDIHAITASNNLLAAAIDTRMFHESTQSDKALFNRLCPP 182
Query: 186 NKEGKRSFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFL 245
NKEGKR+F ++M RRLKK GI KTNPDDLTPEEV KFARLDIDPDSITWRRVMD+NDRFL
Sbjct: 183 NKEGKRTFCNIMHRRLKKLGIDKTNPDDLTPEEVTKFARLDIDPDSITWRRVMDVNDRFL 242
Query: 246 RKITVGQGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVT 305
RKI+VGQGPDEKGMVRET FDISVASEIMAVLALTTSL DMRERLGKMVIGNSK+G+P+T
Sbjct: 243 RKISVGQGPDEKGMVRETGFDISVASEIMAVLALTTSLADMRERLGKMVIGNSKAGEPIT 302
Query: 306 ADDLGIGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGP 365
ADDLG+GGALTVLMKDAI+PTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGP
Sbjct: 303 ADDLGLGGALTVLMKDAINPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGP 362
Query: 366 GGFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDH 425
GGFVVTEAGFG+DIGTEKFMNIKCRYSGLTPQCAI+VAT+RALKMHGGGP VVAGKPLD
Sbjct: 363 GGFVVTEAGFGSDIGTEKFMNIKCRYSGLTPQCAIVVATVRALKMHGGGPQVVAGKPLDR 422
Query: 426 AYLTENVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYD 485
AYLTENV LVEAGC NLARHI+N+KAYG+NV+VAIN FS+DT+AELNAVKKAA+DAGA+D
Sbjct: 423 AYLTENVGLVEAGCVNLARHIINTKAYGSNVVVAINMFSSDTEAELNAVKKAAMDAGAFD 482
Query: 486 AVICSHHAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKSYGASGVEY 545
AVIC+HHAHGG+GAVDLGIAVQKACEN TQPL+FLYPLDI IKEKIEAIAKSYGA+GVEY
Sbjct: 483 AVICTHHAHGGKGAVDLGIAVQKACENVTQPLRFLYPLDISIKEKIEAIAKSYGAAGVEY 542
Query: 546 SEQAEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIY 605
SEQAEKKIE+Y+KQGFS LPICMAKTQYSFS NAA KGAP+GFILPIRDVR SIGAGFIY
Sbjct: 543 SEQAEKKIEMYSKQGFSNLPICMAKTQYSFSHNAAEKGAPSGFILPIRDVRGSIGAGFIY 602
Query: 606 PLVGTMSTMPGLPTRPCFYDIDLDTTTGQVIGLS 639
PLVGTMSTMPGLPTRPCF+DIDLDTTTG+VIGLS
Sbjct: 603 PLVGTMSTMPGLPTRPCFFDIDLDTTTGKVIGLS 636
>C1TC_HUMAN (P11586) C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]
Length = 934
Score = 845 bits (2182), Expect = 0.0
Identities = 426/627 (67%), Positives = 500/627 (78%), Gaps = 3/627 (0%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L++ +PVPSDIDI+ S +P I ++A + L +LYG+ KAKVLLSAL+ L+ DG
Sbjct: 309 LNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDG 368
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGGY
Sbjct: 369 KYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGY 428
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 429 SQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVRR 487
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
FSD+ RRLK+ GI KT+P LT EE+N+FARLDIDP++ITW+RV+D NDRFLRKIT+GQ
Sbjct: 488 FSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQ 547
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EKG R FDISVASEIMAVLALTTSL DMRERLGKMV+ +SK G+PV+A+DLG+
Sbjct: 548 APTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVS 607
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTE 372
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVTE
Sbjct: 608 GALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTE 667
Query: 373 AGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENV 432
AGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY+ EN+
Sbjct: 668 AGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENL 727
Query: 433 ALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHH 492
LVE G +NL + I N++ +G V+VA+N F TDT++EL+ + + + + GA+DAV C+H
Sbjct: 728 ELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHW 787
Query: 493 AHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEK 551
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 788 AEGGKGALALAQAVQRAAQ-APSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQH 846
Query: 552 KIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTM 611
K E+YTKQGF LPICMAKT S S N KG PTGFILPIRD+RAS+GAGF+YPLVGTM
Sbjct: 847 KAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTM 906
Query: 612 STMPGLPTRPCFYDIDLDTTTGQVIGL 638
STMPGLPTRPCFYDIDLD T QV GL
Sbjct: 907 STMPGLPTRPCFYDIDLDPETEQVNGL 933
>C1TC_MOUSE (Q922D8) C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]
Length = 934
Score = 835 bits (2157), Expect = 0.0
Identities = 421/628 (67%), Positives = 496/628 (78%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 308 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKYQPD 367
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 368 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGIKGGAAGGG 427
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 428 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGIR 486
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 487 KFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 546
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMRERLG+MV+ +SK G+P++ +DLG+
Sbjct: 547 QSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPISCEDLGV 606
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
G LTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVT
Sbjct: 607 SGTLTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVT 666
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 667 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 726
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTDAEL+ V + + + GA+DAV C+H
Sbjct: 727 LDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAFDAVKCTH 786
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + I++KI IA + YGA +E +A+
Sbjct: 787 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSIEDKIRIIAQRIYGADDIELLPEAQ 845
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPICMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 846 NKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 905
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV GL
Sbjct: 906 MSTMPGLPTRPCFYDIDLDPETEQVNGL 933
>C1TC_RAT (P27653) C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]
Length = 934
Score = 834 bits (2154), Expect = 0.0
Identities = 420/628 (66%), Positives = 495/628 (77%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
KL++ +PVPSDI I+ S +P I +A + L +LYG+ KAKVLLSALD L+ D
Sbjct: 308 KLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPD 367
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
G YVVV GITPTPLGEGKSTTT+GL QALGA L + V C+RQPSQGPTFGIKGGAAGGG
Sbjct: 368 GKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGIKGGAAGGG 427
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHAITAANNL+AAAID RIFHE TQ+DKALFNRL P + G R
Sbjct: 428 YSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVP-SVNGVR 486
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FSD+ RRL++ GI KT+P LT +E+N+FARLDIDP++ITW+RV+D NDRFLRKIT+G
Sbjct: 487 KFSDIQIRRLRRLGIEKTDPAALTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIG 546
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG R FDISVASEIMAVLALT+SL DMR RLGKMV+ +SK G+P++ +DLG+
Sbjct: 547 QAPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRARLGKMVVASSKKGEPISCEDLGV 606
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GALTVLMKDAI P LMQTLEGTPV VHAGPFANIAHGNSSI+AD+IALKLVGP GFVVT
Sbjct: 607 SGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVT 666
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFGADIG EKF NIKCRYSGL P ++VAT+RALKMHGGGP V AG PL AY E+
Sbjct: 667 EAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEED 726
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ LVE G +NL + I N++ +G V+VA+N F TDTD EL+ + + + + GA+DAV C+H
Sbjct: 727 LDLVEKGFSNLRKQIENARMFGVPVVVAMNAFKTDTDTELDLIGRLSREHGAFDAVKCTH 786
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAE 550
A GG+GA+ L AVQ+A + A + LY L + +++KI IA K YGA +E +A+
Sbjct: 787 WAEGGQGALALAQAVQRASQ-APSSFQLLYDLKLSVEDKIRIIAQKIYGADDIELLPEAQ 845
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
K E+YTKQGF LPICMAKT S S N KG PTGF+LPIRD+RAS+GAGF+YPLVGT
Sbjct: 846 NKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGT 905
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
MSTMPGLPTRPCFYDIDLD T QV GL
Sbjct: 906 MSTMPGLPTRPCFYDIDLDPETEQVNGL 933
>C1TC_SPOFR (Q27772) C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]
Length = 933
Score = 744 bits (1920), Expect = 0.0
Identities = 380/628 (60%), Positives = 465/628 (73%), Gaps = 3/628 (0%)
Query: 12 KLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKD 71
++ +SP PSDI IA S +P ISE+A+ + L N YG+ KAK+ LS LD ++ +
Sbjct: 307 RITPLSPPPSDIVIARSQKPKDISELAHEIGLFSNEVSQYGRTKAKISLSVLDRMRNQQG 366
Query: 72 GYYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGG 131
Y+VV GITPTPLGEGKSTT +GL QAL A + +RQPSQGPTFG+KGGAAGGG
Sbjct: 367 AKYIVVAGITPTPLGEGKSTTLLGLVQALSAHRGRNSFAVMRQPSQGPTFGVKGGAAGGG 426
Query: 132 YSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKR 191
YSQVIPM+EFNLHLTGDIHA TAANNLLAA +D RIFHE TQ D LF+RL P K G R
Sbjct: 427 YSQVIPMEEFNLHLTGDIHAGTAANNLLAAQMDARIFHELTQKDGPLFDRLVPKIK-GVR 485
Query: 192 SFSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVG 251
FS + RRLK+ GI+KT+PD LT E +KFARL+ID I W RV+D+NDR+LRKITVG
Sbjct: 486 KFSPIQLRRLKRLGITKTDPDTLTEGEKSKFARLNIDTSKIMWNRVVDLNDRYLRKITVG 545
Query: 252 QGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGI 311
Q P EKG RETAFDISVASEIMA+LAL + D++ERL MV+ KSG+PVTADDLG+
Sbjct: 546 QSPTEKGFTRETAFDISVASEIMAILALGRDVEDIKERLANMVVALDKSGNPVTADDLGM 605
Query: 312 GGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVT 371
GAL VL++DA PTLMQ+LEGTPVLVH GPFANI HG SSI+ADKIA+KL G G+V T
Sbjct: 606 TGALLVLLRDAFEPTLMQSLEGTPVLVHTGPFANIRHGCSSILADKIAMKLAGENGYVAT 665
Query: 372 EAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTEN 431
EAGFG+DIG EKF +IKCR SG TP CA+IV+T+RALKMHGGGP V AG PL+ Y+ EN
Sbjct: 666 EAGFGSDIGMEKFFDIKCRASGDTPHCAVIVSTVRALKMHGGGPPVSAGMPLNDVYVQEN 725
Query: 432 VALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSH 491
+ L+ G NL +HI N +G V+VAINK DT AELN VK+ A+ GA+ AV+C H
Sbjct: 726 LELLSKGLCNLGKHISNGNKFGVPVVVAINKHGNDTPAELNLVKEFAVKNGAFRAVLCDH 785
Query: 492 HAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQAE 550
A GG GA++L AV +AC++ ++ FLYPL + I+EKI+ IAK YGA VEY+++
Sbjct: 786 WAKGGLGALELADAVIEACDSKSK-FDFLYPLQLSIQEKIQIIAKEMYGAGQVEYTDEVL 844
Query: 551 KKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGT 610
+KI+ +T G+ PICMAKT S + + A KGAPTGF L I + AS+GAGF+ P+VG
Sbjct: 845 EKIKTFTDMGYDKFPICMAKTSNSLTGDPAVKGAPTGFTLKINGIFASVGAGFVVPMVGE 904
Query: 611 MSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
+S MPGLPTRP YDIDL+T TG++ GL
Sbjct: 905 ISKMPGLPTRPSIYDIDLNTKTGEIEGL 932
>C1TC_DROME (O96553) C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]
Length = 968
Score = 729 bits (1883), Expect = 0.0
Identities = 374/622 (60%), Positives = 459/622 (73%), Gaps = 3/622 (0%)
Query: 18 PVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDGYYVVV 77
PVPSDI IA + +P I+ +A + L LYG KAK+ LS L+ L++ + G+YVVV
Sbjct: 348 PVPSDIVIARAQKPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVV 407
Query: 78 GGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGYSQVIP 137
G+TPTPLGEGK+TT +GL QALGA + + +RQPSQGPTFGIKGGAAGGGY+QVIP
Sbjct: 408 AGMTPTPLGEGKTTTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIP 467
Query: 138 MDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRSFSDVM 197
M+EFNLHLTGDIHA++AANNLLAA +DTRIFHE+TQ DKAL++RL P K G+R FS +
Sbjct: 468 MEEFNLHLTGDIHAVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIK-GQRKFSPIQ 526
Query: 198 FRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQGPDEK 257
RRL+K GI+KT+PD LT +E FARLDIDPD+I W RV+DINDR+LR ITVGQ P EK
Sbjct: 527 LRRLQKLGITKTDPDTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEK 586
Query: 258 GMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIGGALTV 317
G+ RET F ISVASEIMAVLAL+ SL DM++RL MV+ K G PVTADDLG+ GAL V
Sbjct: 587 GISRETRFSISVASEIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAV 646
Query: 318 LMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGFGA 377
L+KDA+ P LMQ+LEGTPVLVHAGPFANIAHG +SI+AD++ LKLVG GFV TEAGFG+
Sbjct: 647 LLKDALEPNLMQSLEGTPVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGS 706
Query: 378 DIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENVALVEA 437
DIG EKF NIKCR SG P ++VAT+RA+KMHGGG V G PL+ Y EN+ LV+
Sbjct: 707 DIGMEKFCNIKCRTSGRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQK 766
Query: 438 GCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHHAHGGR 497
G NL +HI N KA+G V+V++N S DT AE VKKAAL+AGA+ AV+ +H A GG
Sbjct: 767 GLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHWADGGA 826
Query: 498 GAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQAEKKIELY 556
GAV L AV KACE Q + LY L++ + +K+ IA + YGA V S AE+K++
Sbjct: 827 GAVQLADAVIKACEQGNQ-FRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRL 885
Query: 557 TKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTMSTMPG 616
T GF LPICM+K SF+ +A KGAP GF L + DV S GAGF+ + G ++ MPG
Sbjct: 886 TDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPG 945
Query: 617 LPTRPCFYDIDLDTTTGQVIGL 638
LPTRP YDIDL+T TG++ GL
Sbjct: 946 LPTRPAIYDIDLNTETGEIEGL 967
>C1TC_YEAST (P07245) C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]
Length = 946
Score = 710 bits (1833), Expect = 0.0
Identities = 359/634 (56%), Positives = 462/634 (72%), Gaps = 10/634 (1%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L +++PVPSDIDI+ + QP I+++A L + + +LYG YKAK+ ++ LQ ++G
Sbjct: 314 LKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKISPKVIERLQTRQNG 373
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
Y++V GITPTPLGEGKSTTT+GL QAL A L K + +RQPS GPT G+KGGAAGGGY
Sbjct: 374 KYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGPTLGVKGGAAGGGY 433
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
SQVIPMDEFNLHLTGDIHAI AANNLLAAAIDTR+FHE+TQ + A F P K GKR
Sbjct: 434 SQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATFYNRLVPRKNGKRK 493
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
F+ M RRL + GI KTNPDDLTPEE+NKFARL+IDPD+IT +RV+DINDR LR+IT+GQ
Sbjct: 494 FTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVDINDRMLRQITIGQ 553
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
P EK R T FDI+VASE+MA+LAL+ L DM+ER+G++V+ + PVT +D+G
Sbjct: 554 APTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADVNRSPVTVEDVGCT 613
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVG-------P 365
GALT L++DAI P LMQTLEGTPVLVHAGPFANI+ G SS++AD++ALKLVG
Sbjct: 614 GALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVALKLVGTEPEAKTE 673
Query: 366 GGFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDH 425
G+VVTEAGF +G E+F NIKCR SGLTP ++VAT+RALK HGG P V G+PL
Sbjct: 674 AGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHGGAPDVKPGQPLPS 733
Query: 426 AYLTENVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYD 485
AY EN+ VE G AN+ + I N K +G V+VAINKF TDT+ E+ A++KAAL+AGA++
Sbjct: 734 AYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIAAIRKAALEAGAFE 793
Query: 486 AVICSHHAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVE 544
AV +H A GG+GA+DL AV +A N FLY ++ +++K+ I K YG + ++
Sbjct: 794 AVTSNHWAEGGKGAIDLAKAVIEA-SNQPVDFHFLYDVNSSVEDKLTTIVQKMYGGAAID 852
Query: 545 YSEQAEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFI 604
+A++KI++Y +QGF LPIC+AKTQYS S +A KG PTGF PIRDVR S GAG++
Sbjct: 853 ILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPIRDVRLSNGAGYL 912
Query: 605 YPLVGTMSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
Y L + T+PGL T + +++D G++ GL
Sbjct: 913 YALAAEIQTIPGLATYAGYMAVEVD-DDGEIDGL 945
>C1TM_YEAST (P09440) C-1-tetrahydrofolate synthase, mitochondrial
precursor (C1-THF synthase) [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9);
Formyltetrahydrofolate synthetase (EC 6.3.
Length = 975
Score = 676 bits (1744), Expect = 0.0
Identities = 351/639 (54%), Positives = 452/639 (69%), Gaps = 15/639 (2%)
Query: 13 LDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDG 72
L + SPVPSDIDI+ + P HI ++A L + + +LYG YKAK+ + L+ ++G
Sbjct: 338 LHLESPVPSDIDISRAQSPKHIKQVAEELGIHSHELELYGHYKAKISPNIFKRLESRENG 397
Query: 73 YYVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGY 132
YV+V GITPTPLGEGKSTTT+GL QAL A L K + +RQPS GPT G+KGGAAGGGY
Sbjct: 398 KYVLVAGITPTPLGEGKSTTTMGLVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGY 457
Query: 133 SQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRS 192
+QVIPMDEFNLHLTGDIHAI+AANNLLAAAIDTR+FHE+TQ + + F + P K+G R
Sbjct: 458 AQVIPMDEFNLHLTGDIHAISAANNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRK 517
Query: 193 FSDVMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQ 252
F+ M RRLK+ I K +PD LTPEEV +FARL+I+PD+IT RRV+DINDR LR+IT+G+
Sbjct: 518 FTPSMQRRLKRLDIEKEDPDALTPEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGE 577
Query: 253 GPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIG 312
EKG R T FDI+VASE+MA+LAL+ SL +M+ER+G+MVIG PVT +D+G
Sbjct: 578 AATEKGFTRTTGFDITVASELMAILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCT 637
Query: 313 GALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVG-------- 364
GALT L++DAI P LMQTLEGTPV+VHAGPFANI+ G SS++AD +ALKLVG
Sbjct: 638 GALTALLRDAIKPNLMQTLEGTPVMVHAGPFANISIGASSVIADLMALKLVGSEKNPLND 697
Query: 365 ----PGGFVVTEAGFGADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAG 420
G+VVTEAGF +G E+F +IKCR SGL P ++VAT+RALK HGG P V G
Sbjct: 698 KNIHEPGYVVTEAGFDFAMGGERFFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPG 757
Query: 421 KPLDHAYLTENVALVEAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALD 480
+ L Y EN+ V G +NL + I N K +G V+VAIN+F TD+ AE+ +KKAAL+
Sbjct: 758 QSLPKEYTEENIDFVAKGVSNLVKQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALN 817
Query: 481 AGAYDAVICSHHAHGGRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYG 539
AGA AV +H GG+GAV+L AV A + + FLY ++ I++K+ +I K YG
Sbjct: 818 AGASHAVTSNHWMEGGKGAVELAHAVVDATKE-PKNFNFLYDVNSSIEDKLTSIVQKMYG 876
Query: 540 ASGVEYSEQAEKKIELYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASI 599
+ +E S +A+KKI+ Y KQGF LPIC+AKTQYS S + + KG P GF PIRDVRASI
Sbjct: 877 GAKIEVSPEAQKKIDTYKKQGFGNLPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASI 936
Query: 600 GAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTTTGQVIGL 638
GAG++Y L + T+PGL T + +++D G++ GL
Sbjct: 937 GAGYLYALAAEIQTIPGLSTYAGYMAVEVD-DDGEIEGL 974
>FTHS_MOOTH (P21164) Formate--tetrahydrofolate ligase (EC 6.3.4.3)
(Formyltetrahydrofolate synthetase) (FHS) (FTHFS)
Length = 559
Score = 515 bits (1327), Expect = e-145
Identities = 285/624 (45%), Positives = 376/624 (59%), Gaps = 67/624 (10%)
Query: 16 VSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDGYYV 75
+S VPSDI+IA + + + E+A L + + +LYGKYKAK+ L L++ DG +
Sbjct: 1 MSKVPSDIEIAQAAKMKPVMELARGLGIQEDEVELYGKYKAKISLDVYRRLKDKPDGKLI 60
Query: 76 VVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGYSQV 135
+V ITPTP GEGK+TT+VGL AL A L K+V+ C+R+PS GP+FGIKGGAAGGGY+QV
Sbjct: 61 LVTAITPTPAGEGKTTTSVGLTDAL-ARLGKRVMVCLREPSLGPSFGIKGGAAGGGYAQV 119
Query: 136 IPMDEFNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRSFSD 195
+PM++ NLH TGDIHA+T A+NLLAA +D
Sbjct: 120 VPMEDINLHFTGDIHAVTYAHNLLAAMVDNH----------------------------- 150
Query: 196 VMFRRLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQGPD 255
+ + N ++ P + TWRRV+D+NDR LR I +G G
Sbjct: 151 ----------LQQGNVLNIDPRTI-------------TWRRVIDLNDRALRNIVIGLGGK 187
Query: 256 EKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIGGAL 315
G+ RET FDISVASE+MA L L + L D++ER ++V+G + G PVTA DL G++
Sbjct: 188 ANGVPRETGFDISVASEVMACLCLASDLMDLKERFSRIVVGYTYDGKPVTAGDLEAQGSM 247
Query: 316 TVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGF 375
+LMKDAI P L+QTLE TP +H GPFANIAHG +SI+A K ALKL +VVTEAGF
Sbjct: 248 ALLMKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIIATKTALKL---ADYVVTEAGF 304
Query: 376 GADIGTEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENVALV 435
GAD+G EKF ++KCRY+G P +IVAT+RALKMHGG P TEN+ +
Sbjct: 305 GADLGAEKFYDVKCRYAGFKPDATVIVATVRALKMHGGVP--------KSDLATENLEAL 356
Query: 436 EAGCANLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHHAHG 495
G ANL +HI N +G +VAIN F TDT+AELN + + AGA + + A G
Sbjct: 357 REGFANLEKHIENIGKFGVPAVVAINAFPTDTEAELNLLYELCAKAGA-EVALSEVWAKG 415
Query: 496 GRGAVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIA-KSYGASGVEYSEQAEKKIE 554
G G ++L V + E+ LY LD+ IK+KI IA + YGA GV Y+ +A+K I+
Sbjct: 416 GEGGLELARKVLQTLESRPSNFHVLYNLDLSIKDKIAKIATEIYGADGVNYTAEADKAIQ 475
Query: 555 LYTKQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTMSTM 614
Y G+ LP+ MAKTQYSFSD+ G P F + +R+VR S G I P+ G + TM
Sbjct: 476 RYESLGYGNLPVVMAKTQYSFSDDMTKLGRPRNFTITVREVRLSAGGRLIVPITGAIMTM 535
Query: 615 PGLPTRPCFYDIDLDTTTGQVIGL 638
PGLP RP +ID+D G + GL
Sbjct: 536 PGLPKRPAACNIDID-ADGVITGL 558
>FTHS_CLOCY (Q07064) Formate--tetrahydrofolate ligase (EC 6.3.4.3)
(Formyltetrahydrofolate synthetase) (FHS) (FTHFS)
Length = 556
Score = 512 bits (1319), Expect = e-144
Identities = 283/620 (45%), Positives = 376/620 (60%), Gaps = 67/620 (10%)
Query: 21 SDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDGYYVVVGGI 80
+D+ IA Q I+E+AN+L + + +LYGKYKAKV L L+ ++ +D V+V I
Sbjct: 3 TDVQIAQEAQMKPITEVANYLGIQDDELELYGKYKAKVSLDVLERQKDKEDAKLVLVTAI 62
Query: 81 TPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGYSQVIPMDE 140
PTP GEGK+TT VGL L + K+ +T +R+PS GP FG+KGGAAGGGY+QV+PMD+
Sbjct: 63 NPTPAGEGKTTTNVGLSMGLNK-IGKRTITALREPSLGPCFGVKGGAAGGGYAQVVPMDD 121
Query: 141 FNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRSFSDVMFRR 200
NLH TGD HAIT+A+NLLAA
Sbjct: 122 INLHFTGDFHAITSAHNLLAA--------------------------------------- 142
Query: 201 LKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQGPDEKGMV 260
L +++ L+I+P I W+RV+D+NDR LR + +G G + G V
Sbjct: 143 -------------LLDNHLHQGNALNINPKKIVWKRVIDMNDRSLRNVIIGLGGNGDGFV 189
Query: 261 RETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIGGALTVLMK 320
R+ FDI+VASEIMA+L L TS++D++ERL KM++ +K G VTA L GA+ +L+K
Sbjct: 190 RQAQFDITVASEIMAILCLATSMSDLKERLSKMIVAYAKDGSAVTAGQLEATGAMALLLK 249
Query: 321 DAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGFGADIG 380
DA+ P L+QTLE TP +H GPFANIAHG +S++A K+ALKL +VVTE GFGAD+G
Sbjct: 250 DAVKPNLVQTLENTPAFIHGGPFANIAHGCNSVLATKVALKL---ADYVVTEGGFGADLG 306
Query: 381 TEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENVALVEAGCA 440
EKF +IK R++GL P C + VAT+RALKM+GG P ENV V+ G A
Sbjct: 307 AEKFFDIKSRFAGLKPNCDVSVATVRALKMNGGVPKT--------ELAAENVEAVKKGVA 358
Query: 441 NLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHHAHGGRGAV 500
NL RHI N +G +VAINKF DT+AEL AV+ A GA D V+ A+GG G V
Sbjct: 359 NLERHIENVAKFGVPAVVAINKFPLDTEAELKAVEDACNAKGA-DVVLSDVWANGGEGGV 417
Query: 501 DLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQAEKKIELYTKQ 559
++ V + CE LY +++ I EKIE IA + Y A GV+++ +K+I K
Sbjct: 418 EMAKKVVEICEKNEANFAPLYDVNLSIPEKIEKIATTIYRADGVDFTSDCKKQIAELEKL 477
Query: 560 GFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTMSTMPGLPT 619
G +PICMAKTQYSFSD+ GAPTGF + +R+VR S GAGFI L G M TMPGLP
Sbjct: 478 GLDKMPICMAKTQYSFSDDPTLLGAPTGFRITVREVRVSAGAGFIVALTGNMMTMPGLPK 537
Query: 620 RPCFYDIDLDTTTGQVIGLS 639
P +D+ +G++IGLS
Sbjct: 538 VPAANGMDI-LESGEIIGLS 556
>FTHS_CLOAC (P13419) Formate--tetrahydrofolate ligase (EC 6.3.4.3)
(Formyltetrahydrofolate synthetase) (FHS) (FTHFS)
Length = 556
Score = 506 bits (1304), Expect = e-143
Identities = 290/619 (46%), Positives = 368/619 (58%), Gaps = 67/619 (10%)
Query: 21 SDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDGYYVVVGGI 80
+DI IA Q HI ++A +++ + +LYGKYKAKV L LD+L++ DG V+V I
Sbjct: 3 TDIQIAQEAQMKHIKDVAELIDIHEDDLELYGKYKAKVSLDVLDQLKDKPDGKLVLVTAI 62
Query: 81 TPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGYSQVIPMDE 140
PTP GEGK+TT +GL L L KK T +R+PS GP+FG+KGGAAGGGY+QV+PM +
Sbjct: 63 NPTPAGEGKTTTNIGLSMGLNK-LGKKTSTALREPSLGPSFGVKGGAAGGGYAQVVPMAD 121
Query: 141 FNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRSFSDVMFRR 200
NLH TGD HAIT+A++LLAA +D + H +
Sbjct: 122 INLHFTGDFHAITSAHSLLAALVDNHLHHGNA---------------------------- 153
Query: 201 LKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQGPDEKGMV 260
L ID + I W+RV+D+NDR LRKI VG G +G+
Sbjct: 154 ------------------------LRIDTNRIVWKRVVDMNDRALRKIVVGLGGKAQGIT 189
Query: 261 RETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIGGALTVLMK 320
RE FDI+VASEIMA+L L D++ERLG MV+ + GD V A DL GALT+++K
Sbjct: 190 REDGFDITVASEIMAILCLANDREDLKERLGNMVVAYNVDGDAVRAKDLEAQGALTLILK 249
Query: 321 DAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGFGADIG 380
DAI+P ++QTLE TP +H GPFANIAHG +S++A K+ALK G + VTEAGFGAD+G
Sbjct: 250 DAINPNIVQTLENTPAFIHGGPFANIAHGCNSVLATKLALK---TGDYAVTEAGFGADLG 306
Query: 381 TEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENVALVEAGCA 440
EKF +IKCRY+GL P A+IVAT+RALKMHGG VA + L TEN+ + G
Sbjct: 307 AEKFFDIKCRYAGLNPDVAVIVATVRALKMHGG----VAKEDLG----TENLDALAKGMT 358
Query: 441 NLARHILNSKAYGANVIVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHHAHGGRGAV 500
NL RHI N +G +VAIN F TDT+AE V + G D I A GG G V
Sbjct: 359 NLERHIENVAKFGVPSVVAINAFPTDTEAEKQLVFDKCKEMGV-DVAISDVFAKGGDGGV 417
Query: 501 DLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQAEKKIELYTKQ 559
+L V CEN K LY ++ I EKI IAK Y A V +S+ A+K+I K
Sbjct: 418 ELAQKVIDVCENKKSDFKVLYDVEESIPEKITKIAKEIYRADKVNFSKAAKKQIAELEKL 477
Query: 560 GFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTMSTMPGLPT 619
G LPICMAKTQYSFSD+ A GAP GF L IRD+ + GAGFI L G + MPGLP
Sbjct: 478 GLDKLPICMAKTQYSFSDDPALLGAPEGFELTIRDLELAAGAGFIVALTGDIMRMPGLPK 537
Query: 620 RPCFYDIDLDTTTGQVIGL 638
P +D+ G++IGL
Sbjct: 538 VPAANRMDV-LPNGEIIGL 555
>FTHS_STRMU (Q59925) Formate--tetrahydrofolate ligase (EC 6.3.4.3)
(Formyltetrahydrofolate synthetase) (FHS) (FTHFS)
Length = 556
Score = 461 bits (1185), Expect = e-129
Identities = 271/621 (43%), Positives = 363/621 (57%), Gaps = 71/621 (11%)
Query: 21 SDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDGYYVVVGGI 80
+DI+IA SV I+ + L + +LYGKYKAK+ + ++E+ G V+V I
Sbjct: 3 TDIEIAQSVDLRPITNVVKKLGFDFDDLELYGKYKAKLTFDKIKAVEENAPGKLVLVTAI 62
Query: 81 TPTPLGEGKSTTTVGLCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGYSQVIPMDE 140
PTP GEGKST T+GL AL + KK + IR+PS GP GIKGGAAGGGY+QV+PM++
Sbjct: 63 NPTPAGEGKSTITIGLADALNK-IGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMED 121
Query: 141 FNLHLTGDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRSFSDVMFRR 200
NLH TGD+HAIT ANN L+A ID + H+ +
Sbjct: 122 INLHFTGDMHAITTANNALSALIDNHL-HQGNE--------------------------- 153
Query: 201 LKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQGPDEKGMV 260
L ID I W+RV+D+NDR LR +TVG G G+
Sbjct: 154 ------------------------LGIDQRRIIWKRVVDLNDRALRHVTVGLGSPINGIP 189
Query: 261 RETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGDPVTADDLGIGGALTVLMK 320
RE FDI+VASEIMA+L L T++ D++ERL +VIG PV DL + GAL +++K
Sbjct: 190 REDGFDITVASEIMAILCLATNVEDLKERLANIVIGYRFDRSPVYVRDLEVQGALALILK 249
Query: 321 DAIHPTLMQTLEGTPVLVHAGPFANIAHGNSSIVADKIALKLVGPGGFVVTEAGFGADIG 380
+AI P L+QT+ GTP VH GPFANIAHG +S++A AL+L + +TEAGFGAD+G
Sbjct: 250 EAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRL---ADYTITEAGFGADLG 306
Query: 381 TEKFMNIKCRYSGLTPQCAIIVATIRALKMHGGGPAVVAGKPLDHAYLTENVALVEAGCA 440
EKF++IK +P +IVATIRALKM+GG VA L+ ENV V+AG A
Sbjct: 307 AEKFLDIKAPNLPTSPDAVVIVATIRALKMNGG----VAKDALNQ----ENVEAVKAGFA 358
Query: 441 NLARHILNSKAYGANVIVAINKFSTDTDAELNAVKK--AALDAGAYDAVICSHHAHGGRG 498
NLARH+ N + YG V+VAIN+F TDT+ E+ ++ AA+D + S A+G G
Sbjct: 359 NLARHVENMRKYGVPVVVAINEFITDTNDEIAVLRNLCAAIDV---PVELASVWANGADG 415
Query: 499 AVDLGIAVQKACENATQPLKFLYPLDIGIKEKIEAIAKS-YGASGVEYSEQAEKKIELYT 557
VDL + EN K LY ++ ++EK+ IAK Y A V + ++A+ +I
Sbjct: 416 GVDLANTLINTIENNPSHYKRLYDNNLSVEEKVTEIAKEIYRADKVIFEKKAKTQIAQIV 475
Query: 558 KQGFSGLPICMAKTQYSFSDNAAAKGAPTGFILPIRDVRASIGAGFIYPLVGTMSTMPGL 617
K G+ LPICMAKTQYSFSD+ GAPTGF + IR++ +GAGFI L G + TMPGL
Sbjct: 476 KNGWDNLPICMAKTQYSFSDDPKLLGAPTGFDITIRELVPKLGAGFIVALTGDVMTMPGL 535
Query: 618 PTRPCFYDIDLDTTTGQVIGL 638
P +P ++D+ G +GL
Sbjct: 536 PKKPAALNMDV-AADGTALGL 555
>SPEN_DROME (Q8SX83) Split ends protein
Length = 5560
Score = 41.2 bits (95), Expect = 0.008
Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 9/120 (7%)
Query: 96 LCQALGAFLDKKVVTCIRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHL---------T 146
+ A A ++V T ++QPS T G+ GG S + P DE++ H+ +
Sbjct: 1197 MMNASAAAKRRRVTTTMQQPSSSSTTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQLHS 1256
Query: 147 GDIHAITAANNLLAAAIDTRIFHESTQSDKALFNRLCPPNKEGKRSFSDVMFRRLKKFGI 206
H + + + T + E + RL PP + + DVM+ L KFG+
Sbjct: 1257 HHSHEASGGESADGSRPGTPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGV 1316
>VG13_BPML5 (Q05219) Gene 13 protein (GP13)
Length = 593
Score = 32.7 bits (73), Expect = 3.0
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 442 LARHILNSKAYGANV-IVAINKFSTDTDAELNAVKKAALDAGAYDAVICSHHAHGGR 497
L +H+LN+K + N +AI K + D+ +++A A L GA + S A GR
Sbjct: 532 LRQHVLNAKRHPTNYDAIAIRKVTKDSSKKIDAAVCAVLAFGARQDYLMSKKARSGR 588
>PDXA_SPHAR (O85987) 4-hydroxythreonine-4-phosphate dehydrogenase
(EC 1.1.1.262) (4-(phosphohydroxy)-L-threonine
dehydrogenase)
Length = 330
Score = 32.7 bits (73), Expect = 3.0
Identities = 20/91 (21%), Positives = 45/91 (48%), Gaps = 10/91 (10%)
Query: 3 SSSSSSVMRKLD-VVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLS 61
S+ S + +KLD V+SP P + + P+ ++ + +H++L + A ++ +
Sbjct: 131 STGSLKLAKKLDRVISPTPGESYLVLLTGPLRVAHLTDHMSLR----QVIDVISADLVAT 186
Query: 62 ALDELQESKDGY-----YVVVGGITPTPLGE 87
A+ +L E+ + + V G+ P +G+
Sbjct: 187 AVGQLHEAMQSWGIAQPRIAVAGLNPHAMGD 217
>MURA_DESTE (Q9ZH21) UDP-N-acetylglucosamine
1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate
transferase) (UDP-N-acetylglucosamine enolpyruvyl
transferase) (Fragment)
Length = 243
Score = 32.7 bits (73), Expect = 3.0
Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 5/77 (6%)
Query: 403 ATIRALKMHGGGPAVVAGKPLDHAYLTENVALVEAGCANLARHILNSKAYGANVIVAINK 462
A +RA + G VVAG + +NV ++ G NL + + + GA + A
Sbjct: 171 ACVRATDLRAGAALVVAGLMAEGETRIDNVQYIDRGYFNLEQKL---RMLGARIWRA--P 225
Query: 463 FSTDTDAELNAVKKAAL 479
+ T A+ NAV+K+AL
Sbjct: 226 YDEKTPAQDNAVRKSAL 242
>PYRG_PYRHO (O59456) CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase)
(CTP synthetase)
Length = 537
Score = 32.3 bits (72), Expect = 3.9
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 13/103 (12%)
Query: 200 RLKKFGISKTNPDDLTPEEVNKFARLDIDPDSITWRRVMDINDRFLRKITVGQGPDEKGM 259
+LK G KT P T V + L I PD+I R + + +KI++ + +
Sbjct: 178 KLKVVGEQKTKP---TQHSVKELRSLGIQPDAIVARSEDPLEEEARKKISLFTNVPREAV 234
Query: 260 VRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIGNSKSGD 302
V +A+D+ E+ +L RE LGK +I K D
Sbjct: 235 V--SAYDVEDTYEVPLLLE--------REGLGKYLIKRLKLED 267
>GUN_BACSZ (P29019) Endoglucanase precursor (EC 3.2.1.4)
(Endo-1,4-beta-glucanase) (Cellulase) (Endo-K)
Length = 463
Score = 32.3 bits (72), Expect = 3.9
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 10/86 (11%)
Query: 1 MTSSSSSSVMRKLDVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLL 60
+T+SS S + K + P P ++ + ++P H+S+ LN +Y Y +K K L
Sbjct: 47 ITNSSQVSAVAK--EMKPFPQQVNYSGILKPNHVSQ--ESLNNAVKNY--YNDWKKKYLK 100
Query: 61 SALDELQESKDGYYVVVGGITPTPLG 86
+ L L G Y V G IT P G
Sbjct: 101 NDLSSL----PGGYYVKGEITGNPDG 122
>DHE2_CLOSY (P24295) NAD-specific glutamate dehydrogenase (EC
1.4.1.2) (NAD-GDH)
Length = 449
Score = 32.3 bits (72), Expect = 3.9
Identities = 59/226 (26%), Positives = 90/226 (39%), Gaps = 29/226 (12%)
Query: 179 FNRLCPPNKEGKRSFSDVMFRRLKKFGISKTNPDDLTPEEVNKF-ARLDIDPDSITWRRV 237
FN P K G R V +K G + D LT + D DP+ + R V
Sbjct: 81 FNGAIGPYKGGLRFAPSVNLSIMKFLGFEQAFKDSLTTLPMGGAKGGSDFDPNGKSDREV 140
Query: 238 MDINDRFLRKITVGQGPDEKGMVRETAFDISVASEIMAVLALTTSLTDMRERLGKMVIG- 296
M F+ ++ GPD + A D+ V + + + R+ +G G
Sbjct: 141 MRFCQAFMTELYRHIGPD----IDVPAGDLGVGAREIGYM-----YGQYRKIVGGFYNGV 191
Query: 297 -----NSKSGDPVTADDLGIGGALTVLMKDAIHPTLMQTLEGTPVLVHAGPFANIAHGNS 351
S G V + G G +V +A+ TL G V + AG F N+A G +
Sbjct: 192 LTGKARSFGGSLVRPEATGYG---SVYYVEAVMKHENDTLVGKTVAL-AG-FGNVAWGAA 246
Query: 352 SIVAD--KIALKLVGPGGFVVTEAGFGADIGTEKFMN--IKCRYSG 393
+A+ A+ L GP G++ G I TE+ +N ++ R SG
Sbjct: 247 KKLAELGAKAVTLSGPDGYIYDPEG----ITTEEKINYMLEMRASG 288
>SDHB_BACSU (O34635) Probable L-serine dehydratase, beta chain (EC
4.3.1.17) (L-serine deaminase) (SDH) (L-SD)
Length = 220
Score = 32.0 bits (71), Expect = 5.1
Identities = 28/156 (17%), Positives = 63/156 (39%), Gaps = 21/156 (13%)
Query: 14 DVVSPVPSDIDIANSVQPIHISEIANHLNLTPNHYDLYGKYKAKVLLSALDELQESKDGY 73
D++ PV +++ I +A L+G+ ++++S E+ G+
Sbjct: 8 DIIGPVMIGPSSSHTAGAARIGRVAR---------SLFGREPERIIVSFYGSFAETYKGH 58
Query: 74 ---YVVVGGITPTPLGEGKSTTTVGLCQALGAFLDKKVVTC---------IRQPSQGPTF 121
++GG+ + + T + + +A G ++ +V I +
Sbjct: 59 GTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPVHPNTAKITISDEKGEL 118
Query: 122 GIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANN 157
+ G + GGG ++ ++ F L L+G+ AI +N
Sbjct: 119 ELTGISIGGGKIEITELNGFELRLSGNHPAILVVHN 154
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.136 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,269,783
Number of Sequences: 164201
Number of extensions: 3411973
Number of successful extensions: 8648
Number of sequences better than 10.0: 29
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 8590
Number of HSP's gapped (non-prelim): 34
length of query: 639
length of database: 59,974,054
effective HSP length: 117
effective length of query: 522
effective length of database: 40,762,537
effective search space: 21278044314
effective search space used: 21278044314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Medicago: description of AC146329.5