BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC145372.5 - phase: 0
(369 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
PDK_DROME (P91622) [Pyruvate dehydrogenase [lipoamide]] kinase, ... 246 9e-65
PDK2_RAT (Q64536) [Pyruvate dehydrogenase [lipoamide]] kinase is... 246 9e-65
PDK2_MOUSE (Q9JK42) [Pyruvate dehydrogenase [lipoamide]] kinase ... 245 1e-64
PDK2_HUMAN (Q15119) [Pyruvate dehydrogenase [lipoamide]] kinase ... 244 3e-64
PDK4_HUMAN (Q16654) [Pyruvate dehydrogenase [lipoamide]] kinase ... 238 2e-62
PDK1_RAT (Q63065) [Pyruvate dehydrogenase [lipoamide]] kinase is... 238 2e-62
PDK1_HUMAN (Q15118) [Pyruvate dehydrogenase [lipoamide]] kinase ... 236 5e-62
PDK4_MOUSE (O70571) [Pyruvate dehydrogenase [lipoamide]] kinase ... 235 2e-61
PDK4_SPETR (O88345) [Pyruvate dehydrogenase [lipoamide]] kinase ... 232 1e-60
PDK4_RAT (O54937) [Pyruvate dehydrogenase [lipoamide]] kinase is... 231 2e-60
PDK_ASCSU (O02623) [Pyruvate dehydrogenase [lipoamide]] kinase, ... 230 4e-60
PDK3_HUMAN (Q15120) [Pyruvate dehydrogenase [lipoamide]] kinase ... 227 3e-59
PDK_CAEEL (Q02332) Probable [pyruvate dehydrogenase [lipoamide]]... 219 9e-57
BCKD_MOUSE (O55028) [3-methyl-2-oxobutanoate dehydrogenase [lipo... 212 1e-54
BCKD_RAT (Q00972) [3-methyl-2-oxobutanoate dehydrogenase [lipoam... 210 4e-54
BCKD_HUMAN (O14874) [3-methyl-2-oxobutanoate dehydrogenase [lipo... 210 5e-54
YIE2_YEAST (P40530) Hypothetical 45.4 kDa protein in CBR5-NOT3 i... 95 3e-19
YGF9_YEAST (P53170) Hypothetical 51.9 kDa protein in PYC1-UBC2 i... 84 4e-16
CHEA_LISMO (Q48768) Chemotaxis protein cheA (EC 2.7.3.-) 42 0.002
CHEA_LISIN (Q92DW2) Chemotaxis protein cheA (EC 2.7.3.-) 40 0.007
>PDK_DROME (P91622) [Pyruvate dehydrogenase [lipoamide]] kinase,
mitochondrial precursor (EC 2.7.1.99) (Pyruvate
dehydrogenase kinase) (DmPDK)
Length = 413
Score = 246 bits (627), Expect = 9e-65
Identities = 146/367 (39%), Positives = 213/367 (57%), Gaps = 19/367 (5%)
Query: 13 SLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLP 72
SL + + + F + +S++ MDFG K I FL KEL +R+A E+ LP
Sbjct: 17 SLAKMLDFYSGFNPSPLSIKQFMDFGQNACEKKSYI---FLRKELPVRLANIMKEIALLP 73
Query: 73 CDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDE-KEFTEVIKAIKVRHNNVVPTMALG 131
+L +V +V WY+ SF D+ + + + +D ++F + I+ RHN+VV TMA G
Sbjct: 74 DNLLHTRSVSEVSSWYVKSFEDVLVYEKAEPTHDNLQKFVADLDLIRNRHNDVVQTMAQG 133
Query: 132 VQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHSPNPPP--HVVGYIH 189
V ++K++ ++ I FLDR YMSRI IRMLI QH L NP +G +
Sbjct: 134 VIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGGNPHAGGRHIGCLD 193
Query: 190 TRMSPVEVARNAVDDARSICSRQYGSAPDVHIY---GDPDFTFP----YVPAHLHLMVFE 242
+V R+A ++AR +C + Y ++P + I +P P YVP+HL+ M+FE
Sbjct: 194 PACDLSDVVRDAYENARFLCDQYYLTSPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFE 253
Query: 243 LVKNSLRAVEERYMNSDKDP-PPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYS 301
L KNS+RAV E + + + D PP+++ + G ED+ +KISD+GGGIPRS ++F Y+YS
Sbjct: 254 LFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYS 313
Query: 302 TARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRL 361
TA P +DL V +AGYGYGLPISRLYARYF GD+ ++S E +GTDA ++L L
Sbjct: 314 TAPQP--SKSDL---HTVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKAL 368
Query: 362 GDSQEPL 368
D L
Sbjct: 369 SDEANEL 375
>PDK2_RAT (Q64536) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 2, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 2) (PDK P45)
Length = 407
Score = 246 bits (627), Expect = 9e-65
Identities = 161/381 (42%), Positives = 223/381 (58%), Gaps = 38/381 (9%)
Query: 3 AKKAIETFSKSLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIA 62
A K IE FSK F + +S++ +DFGS + S FL +EL +R+A
Sbjct: 16 APKYIEHFSK-----------FSPSPLSMKQFLDFGSSNACEKT--SFTFLRQELPVRLA 62
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKV 119
E+ LP + P+V V+ WY+ S DI F + K+ D + +FT+ + I+
Sbjct: 63 NIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRN 121
Query: 120 RHNNVVPTMALGVQQLKKDV-DPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELH-- 176
RHN+VVPTMA GV + K D + NQ+ I FLDRFY+SRI IRMLI QH +
Sbjct: 122 RHNDVVPTMAQGVLEYKDTYGDDPVSNQN---IQYFLDRFYLSRISIRMLINQHTLIFDG 178
Query: 177 SPNPP-PHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY--GDPDFTFP--- 230
S NP P +G I S +V ++A D A+ +C + Y ++PD+ I + T P
Sbjct: 179 STNPAHPKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNATQPIHM 238
Query: 231 -YVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPR 289
YVP+HL+ M+FEL KN++RA E + S PPI+I+VA G ED++IK+SD GGG+P
Sbjct: 239 VYVPSHLYHMLFELFKNAMRATVESH-ESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPL 297
Query: 290 SGLRKIFTYLYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMEN 349
+ ++F+Y+YSTA P G G +AG+GYGLPISRLYA+YF GDLQ+ SME
Sbjct: 298 RKIERLFSYMYSTAPTPQP-----GTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEG 351
Query: 350 YGTDAYLHLSRLG-DSQEPLP 369
+GTDA ++L L DS E LP
Sbjct: 352 FGTDAVIYLKALSTDSVERLP 372
>PDK2_MOUSE (Q9JK42) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 2, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 2)
Length = 407
Score = 245 bits (626), Expect = 1e-64
Identities = 159/381 (41%), Positives = 221/381 (57%), Gaps = 38/381 (9%)
Query: 3 AKKAIETFSKSLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIA 62
A K IE FSK F + +S++ +DFGS + S FL +EL +R+A
Sbjct: 16 APKYIEHFSK-----------FSPSPLSMKQFLDFGSSNACEKT--SFTFLRQELPVRLA 62
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKV 119
E+ LP + P+V V+ WY+ S DI F + K+ D + +FT+ + I+
Sbjct: 63 NIMKEINLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRN 121
Query: 120 RHNNVVPTMALGVQQLKKDV-DPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELH-- 176
RHN+VVPTMA GV + K D + NQ+ I FLDRFY+SRI IRMLI QH +
Sbjct: 122 RHNDVVPTMAQGVLEYKDTYGDDPVSNQN---IQYFLDRFYLSRISIRMLINQHTLIFDG 178
Query: 177 SPNPP-PHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY------GDPDFTF 229
S NP P +G I S +V ++A D A+ +C + Y ++PD+ I +
Sbjct: 179 STNPAHPKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNANQPIHM 238
Query: 230 PYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPR 289
YVP+HL+ M+FEL KN++RA E + S PPI+I+VA G ED++IK+SD GGG+P
Sbjct: 239 VYVPSHLYHMLFELFKNAMRATVESH-ESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPL 297
Query: 290 SGLRKIFTYLYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMEN 349
+ ++F+Y+YSTA P G G +AG+GYGLPISRLYA+YF GDLQ+ SME
Sbjct: 298 RRIERLFSYMYSTAPTPQP-----GTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEG 351
Query: 350 YGTDAYLHLSRLG-DSQEPLP 369
+GTDA ++L L DS E LP
Sbjct: 352 FGTDAVIYLKALSTDSVERLP 372
>PDK2_HUMAN (Q15119) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 2, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 2)
Length = 407
Score = 244 bits (623), Expect = 3e-64
Identities = 158/381 (41%), Positives = 220/381 (57%), Gaps = 38/381 (9%)
Query: 3 AKKAIETFSKSLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIA 62
A K IE FSK F + +S++ +DFGS + S FL +EL +R+A
Sbjct: 16 APKYIEHFSK-----------FSPSPLSMKQFLDFGSSNACEKT--SFTFLRQELPVRLA 62
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKV 119
E+ LP + P+V V+ WY+ S DI F + K+ D + +FT+ + I+
Sbjct: 63 NIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRN 121
Query: 120 RHNNVVPTMALGVQQLKKDV-DPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELH-- 176
RHN+VVPTMA GV + K D + NQ+ I FLDRFY+SRI IRMLI QH +
Sbjct: 122 RHNDVVPTMAQGVLEYKDTYGDDPVSNQN---IQYFLDRFYLSRISIRMLINQHTLIFDG 178
Query: 177 SPNPP-PHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY------GDPDFTF 229
S NP P +G I + EV ++A D A+ +C + Y ++PD+ I
Sbjct: 179 STNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHM 238
Query: 230 PYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPR 289
YVP+HL+ M+FEL KN++RA E + S PPI+++VA G ED++IK+SD GGG+P
Sbjct: 239 VYVPSHLYHMLFELFKNAMRATVESH-ESSLILPPIKVMVALGEEDLSIKMSDRGGGVPL 297
Query: 290 SGLRKIFTYLYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMEN 349
+ ++F+Y+YSTA P G G +AG+GYGLPISRLYA+YF GDLQ+ SME
Sbjct: 298 RKIERLFSYMYSTAPTPQP-----GTG-GTPLAGFGYGLPISRLYAKYFQGDLQLFSMEG 351
Query: 350 YGTDAYLHLSRLG-DSQEPLP 369
+GTDA ++L L DS E LP
Sbjct: 352 FGTDAVIYLKALSTDSVERLP 372
>PDK4_HUMAN (Q16654) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 4, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 4)
Length = 411
Score = 238 bits (607), Expect = 2e-62
Identities = 144/367 (39%), Positives = 217/367 (58%), Gaps = 27/367 (7%)
Query: 17 EVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLS 76
EV + + + +S++ ++DFGS+ + S FL +EL +R+A E++ LP L
Sbjct: 23 EVEHFSRYSPSPLSMKQLLDFGSENACERT--SFAFLRQELPVRLANILKEIDILPTQLV 80
Query: 77 QKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKVRHNNVVPTMALGVQ 133
+V V+ WY+ S D+ F E K+ +D+K +F + + ++ RH+NVVPTMA G+
Sbjct: 81 NTSSVQLVKSWYIQSLMDLVEFHE-KSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGII 139
Query: 134 QLKK--DVDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHSPNPP--PHVVGYIH 189
+ K VDP + NQ+ + FLDRFYM+RI RML+ QH+ + S + P +G I
Sbjct: 140 EYKDACTVDP-VTNQN---LQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSID 195
Query: 190 TRMSPVEVARNAVDDARSICSRQYGSAPDVHI------YGDPDFTFPYVPAHLHLMVFEL 243
V V ++A + +R +C + Y S+P++ + + D YVP+HLH M+FEL
Sbjct: 196 PNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFEL 255
Query: 244 VKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTA 303
KN++RA E N PI +IV G ED+TIKISD GGG+P + ++F+Y YSTA
Sbjct: 256 FKNAMRATVEHQENQPS-LTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTA 314
Query: 304 RNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRL-G 362
P+ +++ N +AG+GYGLPISRLYA+YF GDL + S+ YGTDA ++L L
Sbjct: 315 PTPVMDNSR-----NAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSS 369
Query: 363 DSQEPLP 369
+S E LP
Sbjct: 370 ESIEKLP 376
>PDK1_RAT (Q63065) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 1, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 1) (PDK P48)
Length = 434
Score = 238 bits (607), Expect = 2e-62
Identities = 150/371 (40%), Positives = 224/371 (59%), Gaps = 34/371 (9%)
Query: 17 EVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLS 76
+V + F + +S++ +DFGS + S FL +EL +R+A E+ LP +L
Sbjct: 45 QVDFYARFSPSPLSMKQFLDFGSVNACEKT--SFMFLRQELPVRLANIMKEISLLPDNLL 102
Query: 77 QKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKVRHNNVVPTMALGVQ 133
+ P+V V+ WY+ S +++ F + K+ D K EFT+ + I+ RHN+V+PTMA GV
Sbjct: 103 RTPSVQLVQSWYIQSLQELLDFKD-KSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVT 161
Query: 134 QLKKD--VDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELH----SPNPPPHVVGY 187
+ K+ VDP + +Q+ + FLDRFYMSRI IRML+ QH L SP+ H+ G
Sbjct: 162 EYKESFGVDP-VTSQN---VQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHI-GS 216
Query: 188 IHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY-------GDPDFTFPYVPAHLHLMV 240
I+ VEV ++ ++AR +C Y ++P++ + G P YVP+HL+ MV
Sbjct: 217 INPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAKSPGQP-IQVVYVPSHLYHMV 275
Query: 241 FELVKNSLRAVEERYMNSDKDP-PPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYL 299
FEL KN++RA E + +DK PPI++ V G ED+T+K+SD GGG+P + ++F Y+
Sbjct: 276 FELFKNAMRATMEHH--ADKGVYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYM 333
Query: 300 YSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLS 359
YSTA P E + V +AG+GYGLPISRLYA+YF GDL++ S+E YGTDA +++
Sbjct: 334 YSTAPRPRVETSRA-----VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 388
Query: 360 RLG-DSQEPLP 369
L +S E LP
Sbjct: 389 ALSTESIERLP 399
>PDK1_HUMAN (Q15118) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 1, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 1)
Length = 436
Score = 236 bits (603), Expect = 5e-62
Identities = 148/372 (39%), Positives = 223/372 (59%), Gaps = 34/372 (9%)
Query: 17 EVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLS 76
+V + F + +S++ +DFGS + S FL +EL +R+A E+ LP +L
Sbjct: 45 QVDFYARFSPSPLSMKQFLDFGSVNACEKT--SFMFLRQELPVRLANIMKEISLLPDNLL 102
Query: 77 QKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKVRHNNVVPTMALGVQ 133
+ P+V V+ WY+ S +++ F + K+ D K +FT+ + I+ RHN+V+PTMA GV
Sbjct: 103 RTPSVQLVQSWYIQSLQELLDFKD-KSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVI 161
Query: 134 QLKKD--VDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELH------SPNPPPHVV 185
+ K+ VDP + +Q+ + FLDRFYMSRI IRML+ QH L SP+ H+
Sbjct: 162 EYKESFGVDP-VTSQN---VQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHI- 216
Query: 186 GYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY-------GDPDFTFPYVPAHLHL 238
G I+ + +EV ++ ++AR +C Y ++P++ + G P YVP+HL+
Sbjct: 217 GSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQP-IQVVYVPSHLYH 275
Query: 239 MVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTY 298
MVFEL KN++RA E + N PP I++ V G ED+T+K+SD GGG+P + ++F Y
Sbjct: 276 MVFELFKNAMRATMEHHANRGVYPP-IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNY 334
Query: 299 LYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 358
+YSTA P E + V +AG+GYGLPISRLYA+YF GDL++ S+E YGTDA +++
Sbjct: 335 MYSTAPRPRVETSRA-----VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI 389
Query: 359 SRLG-DSQEPLP 369
L DS E LP
Sbjct: 390 KALSTDSIERLP 401
>PDK4_MOUSE (O70571) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 4, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 4)
Length = 412
Score = 235 bits (599), Expect = 2e-61
Identities = 149/382 (39%), Positives = 221/382 (57%), Gaps = 30/382 (7%)
Query: 4 KKAIETFSKSLI-EEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIA 62
+ A S SL+ EV + + + +S++ ++DFGS+ + S FL +EL +R+A
Sbjct: 9 RSASSLSSASLVPREVELFSRYSPSPLSMKQLLDFGSENACERT--SFAFLRQELPVRLA 66
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKV 119
E++ LP L P+V V+ WY+ S D+ F E K+ D+K EF + + ++
Sbjct: 67 NILKEIDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHE-KSPEDQKALSEFVDTLVKVRN 125
Query: 120 RHNNVVPTMALGVQQLKKD--VDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHS 177
RH+NVVPTMA G+ + K VDP + NQ+ + FLDRFYM+RI RML+ QH+ + S
Sbjct: 126 RHHNVVPTMAQGILEYKDTCTVDP-VTNQN---LQYFLDRFYMNRISTRMLMNQHILIFS 181
Query: 178 PNPP--PHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY-------GDPDFT 228
+ P +G I V V ++A + A+ +C + Y ++P++++ G P
Sbjct: 182 DSKTGNPSHIGSIDPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLTQVNGKFPGQP-IH 240
Query: 229 FPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIP 288
YVP+HLH M+FEL KN++RA E N P+ V G ED+TIKISD GGG+P
Sbjct: 241 IVYVPSHLHHMLFELFKNAMRATVEHQENRPS-LTPVEATVVLGKEDLTIKISDRGGGVP 299
Query: 289 RSGLRKIFTYLYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISME 348
++F+Y YSTA P+ +++ N +AG+GYGLPISRLYA+YF GDL + SM
Sbjct: 300 LRITDRLFSYTYSTAPTPVMDNSR-----NAPLAGFGYGLPISRLYAKYFQGDLNLYSMS 354
Query: 349 NYGTDAYLHLSRL-GDSQEPLP 369
YGTDA ++L L +S E LP
Sbjct: 355 GYGTDAIIYLKALSSESVEKLP 376
>PDK4_SPETR (O88345) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 4, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 4)
Length = 412
Score = 232 bits (592), Expect = 1e-60
Identities = 142/368 (38%), Positives = 217/368 (58%), Gaps = 29/368 (7%)
Query: 17 EVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLS 76
EV + + + +S++ ++DFGS + S FL +EL +R+A E++ LP L+
Sbjct: 23 EVELFSRYSPSPLSMKQLLDFGSDNACERTSFS--FLRQELPVRLANILKEIDVLPDRLT 80
Query: 77 QKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKVRHNNVVPTMALGVQ 133
+V V+ WY+ S ++ F E K+ D+K +F + + ++ RH+NVVPTMA G+
Sbjct: 81 NTSSVQLVKSWYIQSLMELVEFHE-KSPEDQKNLSDFVDTLIKVRNRHHNVVPTMAQGIL 139
Query: 134 QLKKD--VDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHSPNPP--PHVVGYIH 189
+ K VDP + NQ + FLDRFYM+RI RML+ QH+ + S + P +G I
Sbjct: 140 EYKDTCTVDP-VTNQS---LQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSID 195
Query: 190 TRMSPVEVARNAVDDARSICSRQYGSAPDVHIY-------GDPDFTFPYVPAHLHLMVFE 242
+ V V ++A + ++ +C + Y ++P++ + G P YVP+HLH M+FE
Sbjct: 196 PKCDVVAVIQDAFESSKMLCDQYYLTSPELKLTQVNGKFPGQP-IHIVYVPSHLHHMLFE 254
Query: 243 LVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYST 302
L KN++RA ER S P+ +IV G ED+TIKISD GGG+P ++F+Y+YST
Sbjct: 255 LFKNAMRATVER-QESWPSLTPVEVIVVLGKEDLTIKISDRGGGVPLRITDRLFSYMYST 313
Query: 303 ARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRL- 361
A P+ +++ N +AG+GYGLPISRLYA+YF GDL + S+ YGTDA ++L L
Sbjct: 314 APTPVMDNSR-----NAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALS 368
Query: 362 GDSQEPLP 369
+S E LP
Sbjct: 369 SESVEKLP 376
>PDK4_RAT (O54937) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 4, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 4)
Length = 412
Score = 231 bits (589), Expect = 2e-60
Identities = 144/368 (39%), Positives = 214/368 (58%), Gaps = 29/368 (7%)
Query: 17 EVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLS 76
EV + + + +S++ ++DFGS+ + S FL +EL +R+A E++ LP L
Sbjct: 23 EVELFSRYSPSPLSMKQLLDFGSENACERTSFS--FLRQELPVRLANILKEIDILPEHLV 80
Query: 77 QKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKVRHNNVVPTMALGVQ 133
P+V V+ WY+ S D+ F E K+ D+K +F + + ++ RH+NVVPTMA G+
Sbjct: 81 NTPSVQLVKSWYIQSLMDLVEFHE-KSPEDQKVLSDFVDTLVKVRNRHHNVVPTMAQGIL 139
Query: 134 QLKKD--VDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHSPNPP--PHVVGYIH 189
+ K + VDP + NQ+ + FLDRFYM+RI RML+ QH+ + S + P +G I
Sbjct: 140 EYKDNCTVDP-VTNQN---LQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSID 195
Query: 190 TRMSPVEVARNAVDDARSICSRQYGSAPDVHIY-------GDPDFTFPYVPAHLHLMVFE 242
V V +A + A+ +C + Y ++P++ + G P YVP+HLH M+FE
Sbjct: 196 PNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQP-IHIVYVPSHLHHMLFE 254
Query: 243 LVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYST 302
L KN++RA E N P+ V G ED+TIKISD GGG+P ++F+Y YST
Sbjct: 255 LFKNAMRATVEHQENRPF-LTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYST 313
Query: 303 ARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRL- 361
A P+ +++ N +AG+GYGLPISRLYA+YF GDL + SM YGTDA ++L L
Sbjct: 314 APTPVMDNSR-----NAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALS 368
Query: 362 GDSQEPLP 369
+S E LP
Sbjct: 369 SESIEKLP 376
>PDK_ASCSU (O02623) [Pyruvate dehydrogenase [lipoamide]] kinase,
mitochondrial precursor (EC 2.7.1.99) (Pyruvate
dehydrogenase kinase)
Length = 399
Score = 230 bits (587), Expect = 4e-60
Identities = 139/377 (36%), Positives = 220/377 (57%), Gaps = 24/377 (6%)
Query: 4 KKAIETFSKSLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIAR 63
++ + F+ ++ ++ + F+ + ++++ +DFG T K+ + FL EL +R+A
Sbjct: 5 RRLLGPFTSAIARKLEHYSQFQPSSLTIQQYLDFGQTGTMKSSFL---FLKNELLVRLAN 61
Query: 64 RAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMND-EKEFTEVIKAIKVRHN 122
E+ LP L + P+ V +WY +SF D+ F + D +F + ++ I RH+
Sbjct: 62 IMQEISLLPPTLLKMPSRRLVSNWYCESFEDLLQFEHAQVEPDIMSKFNDQLQTILKRHS 121
Query: 123 NVVPTMALGVQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHS---PN 179
VV TMA G+ +L++ I ++ ++ FLDRFY++RI IRML QH+ + P
Sbjct: 122 RVVETMAEGLIELRESEGVDIASERGIQY--FLDRFYINRISIRMLQNQHLVVFGVVLPE 179
Query: 180 PPPHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAP----DVHIYGDPDFTFPYV--P 233
P H+ G I V +A ++AR +C R Y +AP ++H +P V P
Sbjct: 180 SPRHI-GCIDPGCDVESVVHDAYENARFLCERYYLTAPGMKLEMHNSVNPGMPISIVAVP 238
Query: 234 AHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLR 293
+HL+ ++FEL KNS+RA E + +D+D PPI+++V G ED++IKISD GGG+ R+ L
Sbjct: 239 SHLYHIMFELFKNSMRATVENH-GADEDLPPIKVMVVRGAEDLSIKISDRGGGVSRTILD 297
Query: 294 KIFTYLYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTD 353
++FTY+YSTA P + G +AGYGYGLP+SRLYARYF GD+ ++SME YGTD
Sbjct: 298 RLFTYMYSTAPPPPRD------GTQPPLAGYGYGLPLSRLYARYFHGDMYLVSMEGYGTD 351
Query: 354 AYLHLSRLG-DSQEPLP 369
A + L + ++ E LP
Sbjct: 352 AMIFLKAIPVEASEVLP 368
>PDK3_HUMAN (Q15120) [Pyruvate dehydrogenase [lipoamide]] kinase
isozyme 3, mitochondrial precursor (EC 2.7.1.99)
(Pyruvate dehydrogenase kinase isoform 3)
Length = 406
Score = 227 bits (579), Expect = 3e-59
Identities = 143/370 (38%), Positives = 210/370 (56%), Gaps = 29/370 (7%)
Query: 16 EEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDL 75
+++ ++ F + +S++ +DFG + S FL KEL +R+A E+ LP +L
Sbjct: 14 KQIERYSRFSPSPLSIKQFLDFGRDNACEKT--SYMFLRKELPVRLANTMREVNLLPDNL 71
Query: 76 SQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEK---EFTEVIKAIKVRHNNVVPTMALGV 132
+P+V V+ WY+ SF ++ + E K+ D + F +V+ ++ RHN+VVPTMA GV
Sbjct: 72 LNRPSVGLVQSWYMQSFLELLEY-ENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGV 130
Query: 133 QQLKKDV--DPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELH----SPNPPPHVVG 186
+ K+ DP I I FLDRFY +RI RMLI QH L +P P H+ G
Sbjct: 131 IEYKEKFGFDPFISTN----IQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHI-G 185
Query: 187 YIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIYG------DPDFTFPYVPAHLHLMV 240
I + +V ++A + A+ +C + Y AP++ + D YVP+HL M+
Sbjct: 186 SIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHML 245
Query: 241 FELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLY 300
FEL KNS+RA E Y + + P ++ +V G ED++IKISD GGG+P + ++F Y+Y
Sbjct: 246 FELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMY 305
Query: 301 STARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSR 360
STA P L +AG+GYGLPISRLYARYF GDL++ SME GTDA ++L
Sbjct: 306 STAPRP-----SLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA 360
Query: 361 L-GDSQEPLP 369
L +S E LP
Sbjct: 361 LSSESFERLP 370
>PDK_CAEEL (Q02332) Probable [pyruvate dehydrogenase [lipoamide]]
kinase, mitochondrial precursor (EC 2.7.1.99) (Pyruvate
dehydrogenase kinase)
Length = 401
Score = 219 bits (558), Expect = 9e-57
Identities = 140/379 (36%), Positives = 214/379 (55%), Gaps = 26/379 (6%)
Query: 3 AKKAIETFSKSLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIA 62
++K + F SL +++ + F+ + ++++ +DFG TS N S FL EL +R+A
Sbjct: 4 SRKLLGPFVGSLAKKLDYYSQFQPSSLTIQQYLDFGRIGTSAN---SYTFLKNELLVRLA 60
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDE-KEFTEVIKAIKVRH 121
E LP L Q P+ V +WY +SF D+ F + ++ F + + + RH
Sbjct: 61 NIMQEFTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASDSSPEQVARFNDQLTVVLKRH 120
Query: 122 NNVVPTMALGVQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHS---P 178
+VV TMA G+ +L++ I ++ ++ FLDRFY++RI IRML QH+ + P
Sbjct: 121 AHVVETMAEGLIELRESDGVDIASEKGIQY--FLDRFYINRISIRMLQNQHLVVFGNVLP 178
Query: 179 NPPPHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIY-------GDPDFTFPY 231
P HV G I V +A ++AR +C R Y ++P + + G P +
Sbjct: 179 ESPRHV-GCIDPACDVESVVYDAFENARFLCDRYYLTSPSMKLEMHNAVEKGKP-ISIVA 236
Query: 232 VPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSG 291
VP+HL+ M+FEL KN++RA E Y D D P I++ V G ED++IKI D GGG+ R+
Sbjct: 237 VPSHLYHMMFELFKNAMRATVE-YHGVDDDLPDIKVYVVKGQEDLSIKICDRGGGVSRTI 295
Query: 292 LRKIFTYLYSTARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYG 351
L +++ Y+YSTA P + G +AGYGYGLP+SRLYARYF GDL ++SME +G
Sbjct: 296 LERLYNYMYSTAPPPPRD------GTQAPLAGYGYGLPLSRLYARYFLGDLFLVSMEGHG 349
Query: 352 TDAYLHLSRLG-DSQEPLP 369
TDA ++L + ++ E LP
Sbjct: 350 TDACIYLKAVPVEASEVLP 368
>BCKD_MOUSE (O55028) [3-methyl-2-oxobutanoate dehydrogenase
[lipoamide]] kinase, mitochondrial precursor (EC
2.7.1.115) (Branched-chain alpha-ketoacid dehydrogenase
kinase) (BCKDHKIN) (BCKD-kinase)
Length = 412
Score = 212 bits (539), Expect = 1e-54
Identities = 121/342 (35%), Positives = 189/342 (54%), Gaps = 17/342 (4%)
Query: 34 MMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLSQKPAVLKVRDWYLDSFR 93
M+ G +LL S ++L +EL +RIA R LP + P +L V + Y+ +F+
Sbjct: 75 MLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQ 134
Query: 94 DIRSFSEIKNMNDEKEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKIINQDFVEIHQ 153
+ F IK+ DE ++ ++++ + H +VV +A G+++ +K + QD +
Sbjct: 135 KLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI------QDEKLVRY 188
Query: 154 FLDRFYMSRIGIRMLIGQHVELHSPNPPPHVVGYIHTRMSPVEVARNAVDDARSICSRQY 213
FLD+ SR+GIRML H+ LH P VG I TR+SP ++ VD AR +C +Y
Sbjct: 189 FLDKTLTSRLGIRMLATHHLALHEDKPD--FVGIICTRLSPKKIIEKWVDFARRLCEHKY 246
Query: 214 GSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGL 273
G+AP V I G FP++P L ++ EL+KN++RA E ++++ + P + I +A+
Sbjct: 247 GNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANND 306
Query: 274 EDVTIKISDEGGGIPRSGLRKIFTYLYSTAR--------NPLDEHADL-GVGDNVTMAGY 324
D+ I+ISD GGGI L ++ Y ++TA NPL H D+ G + M G+
Sbjct: 307 IDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRINPLFGHLDMHSGGQSGPMHGF 366
Query: 325 GYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRLGDSQE 366
G+GLP SR YA Y GG LQ+ S++ GTD YL L + +E
Sbjct: 367 GFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREE 408
>BCKD_RAT (Q00972) [3-methyl-2-oxobutanoate dehydrogenase
[lipoamide]] kinase, mitochondrial precursor (EC
2.7.1.115) (Branched-chain alpha-ketoacid dehydrogenase
kinase) (BCKDHKIN) (BCKD-kinase)
Length = 412
Score = 210 bits (535), Expect = 4e-54
Identities = 123/373 (32%), Positives = 202/373 (53%), Gaps = 20/373 (5%)
Query: 3 AKKAIETFSKSLIEEVHKWGCFKQTGVSLRYMMDFGSKPTSKNLLISAQFLHKELAIRIA 62
+K +++S I+ V + + T + Y G +LL S ++L +EL +RIA
Sbjct: 47 SKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYS---GRSQDGSHLLKSGRYLQQELPVRIA 103
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEKEFTEVIKAIKVRHN 122
R LP + P +L V + Y+ +F+ + F IK+ DE ++ ++++ + H
Sbjct: 104 HRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHK 163
Query: 123 NVVPTMALGVQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHSPNPPP 182
+VV +A G+++ +K ++ + + + FLD+ SR+GIRML H+ LH P
Sbjct: 164 DVVTLLAEGLRESRKHIEDEKL------VRYFLDKTLTSRLGIRMLATHHLALHEDKPD- 216
Query: 183 HVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFE 242
VG I TR+SP ++ VD AR +C +YG+AP V I G FP++P L ++ E
Sbjct: 217 -FVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPE 275
Query: 243 LVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYST 302
L+KN++RA E ++++ + P + I +A+ D+ I+ISD GGGI L ++ Y ++T
Sbjct: 276 LLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTT 335
Query: 303 AR--------NPLDEHADL-GVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTD 353
A +PL H D+ G + M G+G+GLP SR YA Y GG LQ+ S++ GTD
Sbjct: 336 AEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD 395
Query: 354 AYLHLSRLGDSQE 366
YL L + +E
Sbjct: 396 VYLRLRHIDGREE 408
>BCKD_HUMAN (O14874) [3-methyl-2-oxobutanoate dehydrogenase
[lipoamide]] kinase, mitochondrial precursor (EC
2.7.1.115) (Branched-chain alpha-ketoacid dehydrogenase
kinase) (BCKDHKIN) (BCKD-kinase)
Length = 412
Score = 210 bits (534), Expect = 5e-54
Identities = 119/342 (34%), Positives = 191/342 (55%), Gaps = 17/342 (4%)
Query: 34 MMDFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLSQKPAVLKVRDWYLDSFR 93
M+ G +LL SA++L +EL +RIA R LP + P +L V + Y+ +F+
Sbjct: 75 MLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQ 134
Query: 94 DIRSFSEIKNMNDEKEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKIINQDFVEIHQ 153
+ F IK+ DE ++ ++++ + H +VV +A G+++ +K ++ + + +
Sbjct: 135 KLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKL------VRY 188
Query: 154 FLDRFYMSRIGIRMLIGQHVELHSPNPPPHVVGYIHTRMSPVEVARNAVDDARSICSRQY 213
FLD+ SR+GIRML H+ LH P VG I TR+SP ++ VD AR +C +Y
Sbjct: 189 FLDKTLTSRLGIRMLATHHLALHEDKPD--FVGIICTRLSPKKIIEKWVDFARRLCEHKY 246
Query: 214 GSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGL 273
G+AP V I G FP++P L ++ EL+KN++RA E ++++ + P + I +A+
Sbjct: 247 GNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANND 306
Query: 274 EDVTIKISDEGGGIPRSGLRKIFTYLYSTAR--------NPLDEHADLGVG-DNVTMAGY 324
D+ I+ISD GGGI L ++ Y ++TA +PL H D+ G + M G+
Sbjct: 307 VDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGF 366
Query: 325 GYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRLGDSQE 366
G+GLP SR YA Y GG LQ+ S++ GTD YL L + +E
Sbjct: 367 GFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREE 408
>YIE2_YEAST (P40530) Hypothetical 45.4 kDa protein in CBR5-NOT3
intergenic region
Length = 394
Score = 94.7 bits (234), Expect = 3e-19
Identities = 71/303 (23%), Positives = 141/303 (46%), Gaps = 17/303 (5%)
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEKEFTEVIKAIKVRHN 122
+R ++RLP + P + + YL S + + S + +++ + + H
Sbjct: 90 KRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLDDHE 149
Query: 123 NVVPTMALGVQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGIRMLIGQHVELHSPNPPP 182
+ + +A G+Q+++ PK +I QFL+ RI +++L+ ++ L + N
Sbjct: 150 DAIVVLAKGLQEIQSCY-PKF------QISQFLNFHLKERITMKLLVTHYLSLMAQNKGD 202
Query: 183 ---HVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIYGDP--DFTFPYVPAHLH 237
++G +H + ++ ++ D IC ++ + + P D TF +P L
Sbjct: 203 TNKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQRTPVLIHPPSQDITFTCIPPILE 262
Query: 238 LMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFT 297
++ E+ KN+ A + + + P I ++ D +++ ++I D GGGI +F
Sbjct: 263 YIMTEVFKNAFEA--QIALGKEHMPIEINLLKPDD-DELYLRIRDHGGGITPEVEALMFN 319
Query: 298 YLYST--ARNPLDEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAY 355
Y YST ++ E DL ++G G+GLP+ + Y FGG + + S+ +GTD Y
Sbjct: 320 YSYSTHTQQSADSESTDLPGEQINNVSGMGFGLPMCKTYLELFGGKIDVQSLLGWGTDVY 379
Query: 356 LHL 358
+ L
Sbjct: 380 IKL 382
>YGF9_YEAST (P53170) Hypothetical 51.9 kDa protein in PYC1-UBC2
intergenic region
Length = 445
Score = 84.3 bits (207), Expect = 4e-16
Identities = 64/264 (24%), Positives = 126/264 (47%), Gaps = 19/264 (7%)
Query: 36 DFGSKPTSKNLLISAQFLHKELAIRIARRAVELERLPCDLSQKPAVLKVRDWYLDSFRDI 95
D +K T ++ S +F+ +EL IRIA + +L++LP ++ ++V + Y + F
Sbjct: 90 DDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESF 149
Query: 96 RSFSEIKNMNDEKEFTEVIKAIKVRHNNV-VPTMALGVQQLK-KDVDPKIINQDFVEIHQ 153
R + I+ + D +F + IK + N + +P + +G + D+ P+ ++ Q
Sbjct: 150 RKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPR------EKMDQ 203
Query: 154 FLDRFYMSRIGIRMLIGQHVELHSPN------PPPHVVGYIHTRMSPVEVARNAVDDARS 207
L +RI R+++ +HV +++ N V+G I S + A ++++
Sbjct: 204 LLSDLLRARISRRLIVEEHV-VYTANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQK 262
Query: 208 ICSRQYGS---APDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSD-KDPP 263
Y P+ I GD +F ++P HL ++ E+++N+ A + Y+ + P
Sbjct: 263 FIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPE 322
Query: 264 PIRIIVADGLEDVTIKISDEGGGI 287
PI + V E +ISD+ GG+
Sbjct: 323 PIIVTVVSNDESYLFRISDKAGGV 346
>CHEA_LISMO (Q48768) Chemotaxis protein cheA (EC 2.7.3.-)
Length = 618
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/325 (21%), Positives = 118/325 (35%), Gaps = 55/325 (16%)
Query: 63 RRAVELERLPCDLSQKPAVLKVRDWYLDSFRDIRSFSEIKNMNDEKEFTEVIKAIKVRHN 122
R A+ELE + +D DI ++ + +E E +VI+ IK
Sbjct: 174 REAIELEEFEQSFEVVLESAQTKDEIKAVILDISEIEKV-TVTEEVEEVQVIEPIKK--- 229
Query: 123 NVVPTMALGVQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGIRML-----------IGQ 171
+Q K ++ K I +I + ++ F S I + + +
Sbjct: 230 --------AAKQTTKRLENKTIRVQLEKIEKLMNVFEESVIERARIDEIAEKTNNKELME 281
Query: 172 HVELHSPNPPPHVVGYIHTRMSPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPY 231
H+ S G ++ RM PV+ N +++ G D+ I G
Sbjct: 282 HLGRFSSISKEIQNGLLNMRMVPVDSVFNRFPKMVRTLAKELGKKIDLVIEGADTEVDKI 341
Query: 232 VPAHLHLMVFELVKNSL----RAVEERYMNSDKDPPPIRIIVADGLEDVTIKISDEGGGI 287
V + + L++NS+ VE R N + I + +V I+I+D+G GI
Sbjct: 342 VIDEIGDPLVHLIRNSVDHGAETVEVRRKNGKNETATINLKAFHSGNNVVIEIADDGAGI 401
Query: 288 -PRSGLRK-------------------IFTYLYSTARNPLDEHADLGVGDNVTMAGYGYG 327
R L K IF L+ + + D+ +DL +G G G
Sbjct: 402 NKRKVLEKAIAKNVVTRAESTKMTDAEIFDLLFDSGFSTADQVSDL--------SGRGVG 453
Query: 328 LPISRLYARYFGGDLQIISMENYGT 352
L + R GG + + S EN G+
Sbjct: 454 LDVVRNTILKIGGKISVESSENAGS 478
>CHEA_LISIN (Q92DW2) Chemotaxis protein cheA (EC 2.7.3.-)
Length = 618
Score = 40.4 bits (93), Expect = 0.007
Identities = 60/282 (21%), Positives = 103/282 (36%), Gaps = 43/282 (15%)
Query: 106 DEKEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKIINQDFVEIHQFLDRFYMSRIGI 165
D E +V +V ++ + +Q K ++ K I +I + ++ F S I
Sbjct: 205 DISEIEKVTVTEEVEEVQIIEPIKKAAKQTTKRLENKTIRVQLEKIEKLMNVFEESVIER 264
Query: 166 RML-----------IGQHVELHSPNPPPHVVGYIHTRMSPVEVARNAVDDARSICSRQYG 214
+ + +H+ S G ++ RM PV+ N +++ G
Sbjct: 265 ARIDEIAEKTNNKELMEHLGRFSSISKEIQNGLLNMRMVPVDSVFNRFPKMVRTLAKELG 324
Query: 215 SAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSL----RAVEERYMNSDKDPPPIRIIVA 270
D+ I G V + + L++NS+ VE R N + I +
Sbjct: 325 KKIDLVIEGADTEVDKIVIDEIGDPLVHLIRNSVDHGAETVEVRRKNGKNETATINLKAF 384
Query: 271 DGLEDVTIKISDEGGGI-PRSGLRK-------------------IFTYLYSTARNPLDEH 310
+V I+I D+G GI R L K IF L+ + + D+
Sbjct: 385 HSGNNVVIEIVDDGAGINKRKVLEKAIAKNVVTRAESTKMTDSEIFDLLFDSGFSTADQV 444
Query: 311 ADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGT 352
+DL +G G GL + R GG + + S EN G+
Sbjct: 445 SDL--------SGRGVGLDVVRNTILKIGGKISVESSENAGS 478
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.140 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,238,143
Number of Sequences: 164201
Number of extensions: 1996107
Number of successful extensions: 4574
Number of sequences better than 10.0: 66
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 4443
Number of HSP's gapped (non-prelim): 67
length of query: 369
length of database: 59,974,054
effective HSP length: 112
effective length of query: 257
effective length of database: 41,583,542
effective search space: 10686970294
effective search space used: 10686970294
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Medicago: description of AC145372.5