BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC145222.13 + phase: 0
(411 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MK06_RAT (P27704) Mitogen-activated protein kinase 6 (EC 2.7.1.3... 43 0.002
MK06_HUMAN (Q16659) Mitogen-activated protein kinase 6 (EC 2.7.1... 43 0.002
MK06_MOUSE (Q61532) Mitogen-activated protein kinase 6 (EC 2.7.1... 42 0.004
M14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7... 40 0.008
ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2... 39 0.024
ERN1_HUMAN (O75460) Serine/threonine protein kinase/endoribonucl... 39 0.032
CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.1.37)... 39 0.032
CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.1.37) (... 38 0.054
MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.1.3... 37 0.070
MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.1... 37 0.070
MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.1... 37 0.070
M14A_BRARE (Q9DGE2) Mitogen-activated protein kinase 14a (EC 2.7... 37 0.092
CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.1.37)... 37 0.092
ERN1_MOUSE (Q9EQY0) Serine/threonine protein kinase/endoribonucl... 37 0.12
CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.1.37)... 37 0.12
NTF4_TOBAC (Q40532) Mitogen-activated protein kinase homolog NTF... 36 0.16
MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.... 36 0.16
CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.1.37)... 36 0.20
M14B_CYPCA (Q9I958) Mitogen-activated protein kinase 14b (EC 2.7... 35 0.27
SLT2_YEAST (Q00772) Mitogen-activated protein kinase SLT2/MPK1 (... 35 0.35
>MK06_RAT (P27704) Mitogen-activated protein kinase 6 (EC 2.7.1.37)
(Extracellular signal-regulated kinase 3) (ERK-3)
(p55-MAPK)
Length = 720
Score = 42.7 bits (99), Expect = 0.002
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 30/217 (13%)
Query: 205 NSFERGQSMKRRRRFIIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIP 264
N E+G ++ R + L LRGL Y+H + LH+ L P ++ +NT L+
Sbjct: 117 NVLEQGPLLEEHARLFMYQL---LRGLKYIHSANVLHRDLKPANLFINTED------LVL 167
Query: 265 RLRD--LAFSVSVRYSELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADDIYEAGL 319
++ D LA + YS G L+EGL W R S L + A D++ AG
Sbjct: 168 KIGDFGLARIMDPHYSH---KGHLSEGLVTKWYR----SPRLLLSPNNYTKAIDMWAAGC 220
Query: 320 LFAYLAFVPFCEAGVMDGLSLQRLLEN------TFRLDLEATREYCIADDKLVNAIEFLD 373
+FA + AG + +Q +LE+ R +L + I +D
Sbjct: 221 IFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQ 280
Query: 374 LGDGAGWE---LLQAMLNADFRKRPTAEAVLSHRFMT 407
L G E L+ +L R TAE LSH +M+
Sbjct: 281 LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMS 317
>MK06_HUMAN (Q16659) Mitogen-activated protein kinase 6 (EC
2.7.1.37) (Extracellular signal-regulated kinase 3)
(ERK-3) (MAP kinase isoform p97) (p97-MAPK)
Length = 721
Score = 42.7 bits (99), Expect = 0.002
Identities = 60/217 (27%), Positives = 91/217 (41%), Gaps = 30/217 (13%)
Query: 205 NSFERGQSMKRRRRFIIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIP 264
N E+G ++ R + L LRGL Y+H + LH+ L P ++ +NT L+
Sbjct: 117 NVLEQGPLLEEHARLFMYQL---LRGLKYIHSANVLHRDLKPANLFINTED------LVL 167
Query: 265 RLRD--LAFSVSVRYSELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADDIYEAGL 319
++ D LA + YS G L+EGL W R S L + A D++ AG
Sbjct: 168 KIGDFGLARIMDPHYSH---KGHLSEGLVTKWYR----SPRLLLSPNNYTKAIDMWAAGC 220
Query: 320 LFAYLAFVPFCEAGVMDGLSLQRLLEN------TFRLDLEATREYCIADDKLVNAIEFLD 373
+FA + AG + +Q +LE+ R +L + I +D
Sbjct: 221 IFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQ 280
Query: 374 LGDGAGWE---LLQAMLNADFRKRPTAEAVLSHRFMT 407
L G E L+ +L R TAE LSH +M+
Sbjct: 281 LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMS 317
>MK06_MOUSE (Q61532) Mitogen-activated protein kinase 6 (EC
2.7.1.37) (Extracellular signal-regulated kinase 3)
(ERK-3)
Length = 720
Score = 41.6 bits (96), Expect = 0.004
Identities = 59/217 (27%), Positives = 91/217 (41%), Gaps = 30/217 (13%)
Query: 205 NSFERGQSMKRRRRFIIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIP 264
N E+G ++ R + L LRGL Y+H + LH+ L P ++ +NT L+
Sbjct: 117 NVLEQGPLLEEHARLFMYQL---LRGLKYIHSANVLHRDLKPANLFINTED------LVL 167
Query: 265 RLRD--LAFSVSVRYSELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADDIYEAGL 319
++ D LA + YS G L+EGL W R S L + A D++ AG
Sbjct: 168 KIGDFGLARIMDPHYSH---KGHLSEGLVTKWYR----SPRLLLSPNNYTKAIDMWAAGC 220
Query: 320 LFAYLAFVPFCEAGVMDGLSLQRLLEN------TFRLDLEATREYCIADDKLVNAIEFLD 373
+FA + AG + +Q +L++ R +L + I +D
Sbjct: 221 IFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQ 280
Query: 374 LGDGAGWE---LLQAMLNADFRKRPTAEAVLSHRFMT 407
L G E L+ +L R TAE LSH +M+
Sbjct: 281 LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMS 317
>M14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC
2.7.1.37) (MAP kinase p38b) (D-p38b)
Length = 365
Score = 40.4 bits (93), Expect = 0.008
Identities = 55/195 (28%), Positives = 83/195 (42%), Gaps = 27/195 (13%)
Query: 223 LLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSVRYSELED 282
L+ LRGL Y+H +H+ L P ++++N E LR L F ++ R +E E
Sbjct: 133 LVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCE---------LRILDFGLA-RPAESEM 182
Query: 283 SGPLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAGVMDGLSLQR 342
+G + W RA L + DI+ G + A L G L
Sbjct: 183 TGYVATR-WYRAPEIM----LNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNL 237
Query: 343 LLE------NTF--RLDLEATREYCIADDKLVNAIEFLDLGDGAG---WELLQAMLNADF 391
++E + F R+ E+ R Y I ++ F D+ GA +LL+ ML D
Sbjct: 238 IMEVLGTPADEFMSRISSESARNY-IRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDA 296
Query: 392 RKRPTAEAVLSHRFM 406
KR TAE L+H +M
Sbjct: 297 DKRITAEQALAHPYM 311
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC
2.7.1.37) (Extracellular-regulated kinase A) (Rolled
protein)
Length = 376
Score = 38.9 bits (89), Expect = 0.024
Identities = 56/206 (27%), Positives = 86/206 (41%), Gaps = 37/206 (17%)
Query: 220 IIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLN-TISESEAPYLIPRLRDLAFSVSVRYS 278
I L LRGL Y+H + LH+ L P ++ LN T + + R+ D
Sbjct: 139 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIAD---------P 189
Query: 279 ELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADDIYEAGLLFA-YLAFVP-FCEAG 333
E + +G LTE + W RA L + + + DI+ G + A L+ P F
Sbjct: 190 EHDHTGFLTEYVATRWYRAPE----IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 245
Query: 334 VMDGLS-LQRLLENTFRLDLEATREYCIADDKLVNAIEFLDLGDGAGW------------ 380
+D L+ + +L + R DLE CI ++K N +E L W
Sbjct: 246 YLDQLNHILGVLGSPSRDDLE-----CIINEKARNYLESLPFKPNVPWAKLFPNADALAL 300
Query: 381 ELLQAMLNADFRKRPTAEAVLSHRFM 406
+LL ML + KR E L+H ++
Sbjct: 301 DLLGKMLTFNPHKRIPVEEALAHPYL 326
>ERN1_HUMAN (O75460) Serine/threonine protein
kinase/endoribonuclease IRE1 precursor
(Inositol-requiring 1) (hIRE1p) (IRE1a) (Ire1alpha)
(Endoplasmic reticulum-to-nucleus signaling 1)
[Includes: Serine/threonine protein kinase (EC
2.7.1.37); Endoribonucle
Length = 977
Score = 38.5 bits (88), Expect = 0.032
Identities = 53/187 (28%), Positives = 81/187 (42%), Gaps = 23/187 (12%)
Query: 221 IKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSV-RYSE 279
I LLQ GLA++H + +H+ L P ++ ++ + + L ++V R+S
Sbjct: 666 ITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSF 725
Query: 280 LEDSG-PLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAGVMDGL 338
SG P TEG W S E + + DI+ AG +F Y+ E G
Sbjct: 726 SRRSGVPGTEG-WIAPEMLSE-DCKENPTYTV--DIFSAGCVFYYVV----SEGSHPFGK 777
Query: 339 SLQRLLENTFRLDLEATREYCIADDKLVNAIEFLDLGDGAGWELLQAMLNADFRKRPTAE 398
SLQR + L A C+ +K + I EL++ M+ D +KRP+A
Sbjct: 778 SLQRQAN----ILLGACSLDCLHPEKHEDVI---------ARELIEKMIAMDPQKRPSAN 824
Query: 399 AVLSHRF 405
VL H F
Sbjct: 825 DVLKHPF 831
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.1.37)
(Tau protein kinase II catalytic subunit) (TPKII
catalytic subunit) (Proline-directed protein kinase 33
kDa subunit) (PDPK)
Length = 292
Score = 38.5 bits (88), Expect = 0.032
Identities = 50/195 (25%), Positives = 81/195 (40%), Gaps = 33/195 (16%)
Query: 228 LRGLAYMHDHDRLHQSLGPFSVSLNTISESE-APYLIPRLRDLAFSVSVRYSELEDSGPL 286
L+GL + H + LH+ L P ++ +N E + A + + R AF + VR E
Sbjct: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAE----- 161
Query: 287 TEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAG--VMDGLSLQRLL 344
LW R S + + + D++ AG +FA LA AG + G + L
Sbjct: 162 VVTLWYR----SPDVLFGAKLYSTSIDMWSAGCIFAELA-----NAGRPLFPGNDVDDQL 212
Query: 345 ENTFRLDLEATREYCIADDKL------------VNAIEFLDLGDGAGWELLQAMLNADFR 392
+ FRL T E A KL + + + + G +LLQ +L +
Sbjct: 213 KRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272
Query: 393 KRPTAEAVLSHRFMT 407
+R +AE L H + +
Sbjct: 273 QRISAEEALQHPYFS 287
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.1.37) (Tau
protein kinase II catalytic subunit) (TPKII catalytic
subunit) (Serine/threonine-protein kinase PSSALRE)
Length = 292
Score = 37.7 bits (86), Expect = 0.054
Identities = 51/200 (25%), Positives = 82/200 (40%), Gaps = 33/200 (16%)
Query: 223 LLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESE-APYLIPRLRDLAFSVSVRYSELE 281
LL L+GL + H + LH+ L P ++ +N E + A + + R AF + VR E
Sbjct: 106 LLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAE 161
Query: 282 DSGPLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAG--VMDGLS 339
LW R + + + D++ AG +FA LA AG + G
Sbjct: 162 -----VVTLWYRPPD----VLFGAKLYSTSIDMWSAGCIFAELA-----NAGRPLFPGND 207
Query: 340 LQRLLENTFRLDLEATREYCIADDKL------------VNAIEFLDLGDGAGWELLQAML 387
+ L+ FRL T E A KL + + + + G +LLQ +L
Sbjct: 208 VDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLL 267
Query: 388 NADFRKRPTAEAVLSHRFMT 407
+ +R +AE L H + +
Sbjct: 268 KCNPVQRISAEEALQHPYFS 287
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.1.37)
(Extracellular signal-regulated kinase 1) (ERK-1)
(Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1)
(p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated
protein-2 kinase) (MNK1)
Length = 380
Score = 37.4 bits (85), Expect = 0.070
Identities = 56/228 (24%), Positives = 95/228 (41%), Gaps = 37/228 (16%)
Query: 198 VSKLSSWNSFERGQSMKRRRRFIIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISES 257
V L + ++ +S + I L LRGL Y+H + LH+ L P ++ +NT +
Sbjct: 122 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 181
Query: 258 E-APYLIPRLRDLAFSVSVRYSELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADD 313
+ + + R+ D E + +G LTE + W RA L + + + D
Sbjct: 182 KICDFGLARIAD---------PEHDHTGFLTEYVATRWYRAPE----IMLNSKGYTKSID 228
Query: 314 IYEAGLLFA-YLAFVP-FCEAGVMDGLS-LQRLLENTFRLDLEATREYCIADDKLVNAIE 370
I+ G + A L+ P F +D L+ + +L + + DL CI + K N ++
Sbjct: 229 IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN-----CIINMKARNYLQ 283
Query: 371 FLDLGDGAGW------------ELLQAMLNADFRKRPTAEAVLSHRFM 406
L W +LL ML + KR T E L+H ++
Sbjct: 284 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC
2.7.1.37) (Extracellular signal-regulated kinase 1)
(ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1)
(MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK)
(Microtubule-associated protein-2 kinase) (MNK1)
Length = 380
Score = 37.4 bits (85), Expect = 0.070
Identities = 56/228 (24%), Positives = 95/228 (41%), Gaps = 37/228 (16%)
Query: 198 VSKLSSWNSFERGQSMKRRRRFIIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISES 257
V L + ++ +S + I L LRGL Y+H + LH+ L P ++ +NT +
Sbjct: 122 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 181
Query: 258 E-APYLIPRLRDLAFSVSVRYSELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADD 313
+ + + R+ D E + +G LTE + W RA L + + + D
Sbjct: 182 KICDFGLARIAD---------PEHDHTGFLTEYVATRWYRAPE----IMLNSKGYTKSID 228
Query: 314 IYEAGLLFA-YLAFVP-FCEAGVMDGLS-LQRLLENTFRLDLEATREYCIADDKLVNAIE 370
I+ G + A L+ P F +D L+ + +L + + DL CI + K N ++
Sbjct: 229 IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN-----CIINMKARNYLQ 283
Query: 371 FLDLGDGAGW------------ELLQAMLNADFRKRPTAEAVLSHRFM 406
L W +LL ML + KR T E L+H ++
Sbjct: 284 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC
2.7.1.37) (Extracellular signal-regulated kinase 1)
(ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1)
(MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK)
(Microtubule-associated protein-2 kinase)
Length = 379
Score = 37.4 bits (85), Expect = 0.070
Identities = 56/228 (24%), Positives = 95/228 (41%), Gaps = 37/228 (16%)
Query: 198 VSKLSSWNSFERGQSMKRRRRFIIKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISES 257
V L + ++ +S + I L LRGL Y+H + LH+ L P ++ +NT +
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 258 E-APYLIPRLRDLAFSVSVRYSELEDSGPLTEGL---WARASAASAFTYLEKRAFGIADD 313
+ + + R+ D E + +G LTE + W RA L + + + D
Sbjct: 181 KICDFGLARIAD---------PEHDHTGFLTEYVATRWYRAPE----IMLNSKGYTKSID 227
Query: 314 IYEAGLLFA-YLAFVP-FCEAGVMDGLS-LQRLLENTFRLDLEATREYCIADDKLVNAIE 370
I+ G + A L+ P F +D L+ + +L + + DL CI + K N ++
Sbjct: 228 IWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN-----CIINMKARNYLQ 282
Query: 371 FLDLGDGAGW------------ELLQAMLNADFRKRPTAEAVLSHRFM 406
L W +LL ML + KR T E L+H ++
Sbjct: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330
>M14A_BRARE (Q9DGE2) Mitogen-activated protein kinase 14a (EC
2.7.1.37) (Mitogen-activated protein kinase p38a) (MAP
kinase p38a) (zp38a)
Length = 361
Score = 37.0 bits (84), Expect = 0.092
Identities = 51/194 (26%), Positives = 82/194 (41%), Gaps = 27/194 (13%)
Query: 223 LLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSVRYSELED 282
L+ LRGL Y+H D +H+ L P ++++N E L+ L F ++ R+++ E
Sbjct: 131 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---------LKILDFGLA-RHTDDEM 180
Query: 283 SGPLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAGVMDGLSLQR 342
+G + W RA L + + DI+ G + A L G LQ+
Sbjct: 181 TGYVAT-RWYRAPE----IMLNWMHYNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQ 235
Query: 343 LLENT--------FRLDLEATREYCIADDKLVNAIEFLDLGDGA---GWELLQAMLNADF 391
++ T R+ R Y I+ + F D+ GA +LL+ ML D
Sbjct: 236 IMRLTGTPPSSLISRMPSHEARTY-ISSLPQMPKRNFADVFIGANPQAVDLLEKMLVLDT 294
Query: 392 RKRPTAEAVLSHRF 405
KR TA L+H +
Sbjct: 295 DKRITAAEALAHPY 308
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.1.37)
(Tau protein kinase II catalytic subunit) (TPKII
catalytic subunit) (Serine/threonine-protein kinase
PSSALRE) (CRK6)
Length = 292
Score = 37.0 bits (84), Expect = 0.092
Identities = 49/195 (25%), Positives = 80/195 (40%), Gaps = 33/195 (16%)
Query: 228 LRGLAYMHDHDRLHQSLGPFSVSLNTISESE-APYLIPRLRDLAFSVSVRYSELEDSGPL 286
L+GL + H + LH+ L P ++ +N E + A + + R AF + VR E
Sbjct: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAE----- 161
Query: 287 TEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAG--VMDGLSLQRLL 344
LW R + + + D++ AG +FA LA AG + G + L
Sbjct: 162 VVTLWYRPPD----VLFGAKLYSTSIDMWSAGCIFAELA-----NAGRPLFPGNDVDDQL 212
Query: 345 ENTFRLDLEATREYCIADDKL------------VNAIEFLDLGDGAGWELLQAMLNADFR 392
+ FRL T E A KL + + + + G +LLQ +L +
Sbjct: 213 KRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272
Query: 393 KRPTAEAVLSHRFMT 407
+R +AE L H + +
Sbjct: 273 QRISAEEALQHPYFS 287
>ERN1_MOUSE (Q9EQY0) Serine/threonine protein
kinase/endoribonuclease IRE1 precursor
(Inositol-requiring 1) (IRE1a) (Ire1alpha) (Endoplasmic
reticulum-to-nucleus signaling 1) [Includes:
Serine/threonine protein kinase (EC 2.7.1.37);
Endoribonuclease (EC 3
Length = 977
Score = 36.6 bits (83), Expect = 0.12
Identities = 52/187 (27%), Positives = 80/187 (41%), Gaps = 23/187 (12%)
Query: 221 IKLLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSV-RYSE 279
I LL GLA++H + +H+ L P ++ L+ + + L ++V R+S
Sbjct: 666 ITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSF 725
Query: 280 LEDSG-PLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAGVMDGL 338
SG P TEG W S + + + DI+ AG +F Y+ E G
Sbjct: 726 SRRSGVPGTEG-WIAPEMLSE-DCKDNPTYTV--DIFSAGCVFYYV----ISEGNHPFGK 777
Query: 339 SLQRLLENTFRLDLEATREYCIADDKLVNAIEFLDLGDGAGWELLQAMLNADFRKRPTAE 398
SLQR + L A C DK + I EL++ M+ D ++RP+A+
Sbjct: 778 SLQRQAN----ILLGACNLDCFHSDKHEDVI---------ARELIEKMIAMDPQQRPSAK 824
Query: 399 AVLSHRF 405
VL H F
Sbjct: 825 HVLKHPF 831
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.1.37)
(Neuronal cyclin-dependent kinase 5)
Length = 292
Score = 36.6 bits (83), Expect = 0.12
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 228 LRGLAYMHDHDRLHQSLGPFSVSLNTISESE-APYLIPRLRDLAFSVSVRYSELEDSGPL 286
L+GLA+ H + LH+ L P ++ +N E + A + + R AF + VR E
Sbjct: 111 LKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAE----- 161
Query: 287 TEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAG--VMDGLSLQRLL 344
LW R + + + D++ AG +FA LA AG + G + L
Sbjct: 162 VVTLWYRPPD----VLFGAKLYSTSIDMWSAGCIFAELA-----NAGRPLFPGNDVDDQL 212
Query: 345 ENTFRLDLEATREYCIADDKL------------VNAIEFLDLGDGAGWELLQAMLNADFR 392
+ FRL T E A KL ++ + + + G +LLQ +L +
Sbjct: 213 KRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPV 272
Query: 393 KRPTAEAVLSHRF 405
+R A+ L H +
Sbjct: 273 QRICADEALQHPY 285
>NTF4_TOBAC (Q40532) Mitogen-activated protein kinase homolog NTF4
(EC 2.7.1.37) (P45)
Length = 393
Score = 36.2 bits (82), Expect = 0.16
Identities = 47/190 (24%), Positives = 74/190 (38%), Gaps = 24/190 (12%)
Query: 228 LRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSVRYSELEDSGPLT 287
LRGL Y+H + LH+ L P ++ LN + L+ F ++ SE +
Sbjct: 171 LRGLKYIHSANVLHRDLKPSNLLLNANCD---------LKICDFGLARVTSETDFMTEYV 221
Query: 288 EGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAGVMDGLSLQRLLENT 347
W RA L + A D++ G +F L G D + RLL
Sbjct: 222 VTRWYRAPE----LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPG-RDHVHQLRLLMEL 276
Query: 348 FRLDLEATREYCIADDKLV----------NAIEFLDLGDGAGWELLQAMLNADFRKRPTA 397
EA E+ + K + +E + A +L++ ML D R+R T
Sbjct: 277 IGTPSEAEMEFLNENAKRYIRQLPLYRRQSFVEKFPHVNPAAIDLVEKMLTFDPRRRITV 336
Query: 398 EAVLSHRFMT 407
E L+H ++T
Sbjct: 337 EDALAHPYLT 346
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC
2.7.1.37) (Mitogen-activated protein kinase p38alpha)
(MAP kinase p38alpha)
Length = 359
Score = 36.2 bits (82), Expect = 0.16
Identities = 54/194 (27%), Positives = 83/194 (41%), Gaps = 27/194 (13%)
Query: 223 LLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSVRYSELED 282
L+ LRGL Y+H D +H+ L P ++++N E L+ L F ++ R+++ E
Sbjct: 129 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---------LKILDFGLA-RHTDDEM 178
Query: 283 SGPLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYL--AFVPFCEAGVMDGLSL 340
+G + W RA L + DI+ G + A L F +D L L
Sbjct: 179 TGYVAT-RWYRAPE----IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 233
Query: 341 QRLLENTFRLDL------EATREYCIADDKLVNAIEFLDLGDGA---GWELLQAMLNADF 391
L T DL E+ R Y I + + F ++ GA +LL+ ML D
Sbjct: 234 ILRLVGTPGADLLKKISSESARNY-IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS 292
Query: 392 RKRPTAEAVLSHRF 405
KR TA L+H +
Sbjct: 293 DKRITAAQALAHAY 306
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.1.37)
(Tau protein kinase II catalytic subunit) (TPKII
catalytic subunit) (Serine/threonine-protein kinase
PSSALRE)
Length = 292
Score = 35.8 bits (81), Expect = 0.20
Identities = 48/195 (24%), Positives = 80/195 (40%), Gaps = 33/195 (16%)
Query: 228 LRGLAYMHDHDRLHQSLGPFSVSLNTISESE-APYLIPRLRDLAFSVSVRYSELEDSGPL 286
L+GL + H + LH+ L P ++ +N E + A + + R AF + VR E
Sbjct: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAE----- 161
Query: 287 TEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAG--VMDGLSLQRLL 344
LW R + + + D++ AG +FA LA AG + G + L
Sbjct: 162 VVTLWYRPPD----VLFGAKLYSTSIDMWSAGCIFAELA-----NAGRPLFPGNDVDDQL 212
Query: 345 ENTFRLDLEATREYCIADDKL------------VNAIEFLDLGDGAGWELLQAMLNADFR 392
+ FRL T E + KL + + + + G +LLQ +L +
Sbjct: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272
Query: 393 KRPTAEAVLSHRFMT 407
+R +AE L H + +
Sbjct: 273 QRISAEEALQHPYFS 287
>M14B_CYPCA (Q9I958) Mitogen-activated protein kinase 14b (EC
2.7.1.37) (Mitogen-activated protein kinase p38b) (MAP
kinase p38b) (cp38b)
Length = 361
Score = 35.4 bits (80), Expect = 0.27
Identities = 51/194 (26%), Positives = 80/194 (40%), Gaps = 27/194 (13%)
Query: 223 LLQGALRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSVRYSELED 282
L+ LRGL Y+H D +H+ L P ++++N E L+ L F ++ R ++ E
Sbjct: 131 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---------LKILDFGLA-RLTDDEM 180
Query: 283 SGPLTEGLWARASAASAFTYLEKRAFGIADDIYEAGLLFAYLAFVPFCEAGVMDGLSLQR 342
+G + W RA L + + DI+ G + A L G LQ+
Sbjct: 181 TGYVAT-RWYRAPE----IMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQ 235
Query: 343 LLENT--------FRLDLEATREYCIADDKLVNAIEFLDLGDGA---GWELLQAMLNADF 391
++ T R+ R Y I + F D+ GA +LL+ ML D
Sbjct: 236 IMRLTGTPPASLISRMPSHEARNY-INSLSYMPKRNFADVFVGANPMAVDLLEKMLVLDT 294
Query: 392 RKRPTAEAVLSHRF 405
KR TA L+H +
Sbjct: 295 DKRITASQALAHPY 308
>SLT2_YEAST (Q00772) Mitogen-activated protein kinase SLT2/MPK1 (EC
2.7.1.37) (MAP kinase MPK1)
Length = 484
Score = 35.0 bits (79), Expect = 0.35
Identities = 51/197 (25%), Positives = 88/197 (43%), Gaps = 32/197 (16%)
Query: 228 LRGLAYMHDHDRLHQSLGPFSVSLNTISESEAPYLIPRLRDLAFSVSVRYSE--LEDSGP 285
L GL Y+H D LH+ L P ++ +N + L+ F ++ YSE +E+S
Sbjct: 138 LCGLKYIHSADVLHRDLKPGNLLVNADCQ---------LKICDFGLARGYSENPVENSQF 188
Query: 286 LTEGL---WARASAASAFTYLEKRAFGIADDIYEAGLLFA-YLAFVPFCEAGVMDGLSLQ 341
LTE + W RA L + + A D++ AG + A +L P + G L
Sbjct: 189 LTEYVATRWYRAPE----IMLSYQGYTKAIDVWSAGCILAEFLGGKPIFK-GKDYVNQLN 243
Query: 342 RLL--------ENTFRLDLEATREYCIADDKLVNAIEFLDL---GDGAGWELLQAMLNAD 390
++L E R+ + ++Y I + + F++L + +LL+ ML D
Sbjct: 244 QILQVLGTPPDETLRRIGSKNVQDY-IHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFD 302
Query: 391 FRKRPTAEAVLSHRFMT 407
+KR T + L H +++
Sbjct: 303 PQKRITVDEALEHPYLS 319
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.319 0.135 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,760,088
Number of Sequences: 164201
Number of extensions: 1814364
Number of successful extensions: 4609
Number of sequences better than 10.0: 80
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 4573
Number of HSP's gapped (non-prelim): 92
length of query: 411
length of database: 59,974,054
effective HSP length: 113
effective length of query: 298
effective length of database: 41,419,341
effective search space: 12342963618
effective search space used: 12342963618
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Medicago: description of AC145222.13