BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC145202.5 - phase: 0 /pseudo
(1053 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
TOP2_PEA (O24308) DNA topoisomerase II (EC 5.99.1.3) (PsTopII) 988 0.0
TOP2_ARATH (P30182) DNA topoisomerase II (EC 5.99.1.3) 825 0.0
TOP2_PLAFK (P41001) DNA topoisomerase II (EC 5.99.1.3) 630 e-180
TP2A_CRIGR (P41515) DNA topoisomerase II, alpha isozyme (EC 5.99... 620 e-177
TP2A_CHICK (O42130) DNA topoisomerase II, alpha isozyme (EC 5.99... 620 e-177
TP2A_HUMAN (P11388) DNA topoisomerase II, alpha isozyme (EC 5.99... 618 e-176
TP2B_MOUSE (Q64511) DNA topoisomerase II, beta isozyme (EC 5.99.... 617 e-176
TOP2_SCHPO (P08096) DNA topoisomerase II (EC 5.99.1.3) 617 e-176
TOP2_YEAST (P06786) DNA topoisomerase II (EC 5.99.1.3) 616 e-175
TP2B_CHICK (O42131) DNA topoisomerase II, beta isozyme (EC 5.99.... 615 e-175
TP2A_RAT (P41516) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3) 615 e-175
TP2B_HUMAN (Q02880) DNA topoisomerase II, beta isozyme (EC 5.99.... 615 e-175
TP2B_CRILO (Q64399) DNA topoisomerase II, beta isozyme (EC 5.99.... 614 e-175
TP2A_PIG (O46374) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3) 612 e-174
TP2A_MOUSE (Q01320) DNA topoisomerase II, alpha isozyme (EC 5.99... 610 e-174
TOP2_DROME (P15348) DNA topoisomerase II (EC 5.99.1.3) 604 e-172
TOP2_CAEEL (Q23670) Probable DNA topoisomerase II (EC 5.99.1.3) 604 e-172
TOP2_PENCH (Q9Y8G8) DNA topoisomerase II (EC 5.99.1.3) 595 e-169
TOP2_CANGA (O93794) DNA topoisomerase II (EC 5.99.1.3) 592 e-168
TOP2_CANAL (P87078) DNA topoisomerase II (EC 5.99.1.3) 590 e-168
>TOP2_PEA (O24308) DNA topoisomerase II (EC 5.99.1.3) (PsTopII)
Length = 1462
Score = 988 bits (2553), Expect = 0.0
Identities = 560/966 (57%), Positives = 674/966 (68%), Gaps = 72/966 (7%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
WT V FKPDL+KF M LE+DV+ALMKKRVLDMA C G+TV V LNGT+I KSF+DYA+
Sbjct: 203 WTKVTFKPDLEKFKMAYLEEDVVALMKKRVLDMAGCFGKTVKVELNGTLIRFKSFRDYAD 262
Query: 190 FFL---DRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQ 246
FL +++KP PLPR HAK+GDR EIC+SLSDG+FQQVSFVNSIATIKGGTHVDYIT Q
Sbjct: 263 LFLKCAEKSKPMPLPRIHAKVGDRWEICISLSDGQFQQVSFVNSIATIKGGTHVDYITNQ 322
Query: 247 ITTYIKKEV-LKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLKF- 304
ITTYI +V KKK NV A TVKN LWVFVN+LIDNPAF+SQTKE LTT+ A G K
Sbjct: 323 ITTYIMNKVNKKKKDANVKAHTVKNHLWVFVNSLIDNPAFDSQTKETLTTRQASFGSKCD 382
Query: 305 FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-----------------DAKLAGRPDSGKC 347
P SML DV+KS I+D LL FK + DA AG +S KC
Sbjct: 383 VPESMLKDVEKSGIVDTLLSWADFKQSKDLKKTDGTKTQRLRGCKAEDANEAGGRNSEKC 442
Query: 348 TLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATR-DSRKLFKKKEIQNLMAIL 406
TLILT+G K LAM+GLS VV D YGVFPL KLLN S+++ +EIQN+ IL
Sbjct: 443 TLILTEGDSAKALAMAGLS-VVGRDHYGVFPLRGKLLNVREASSKQIMDNEEIQNIKKIL 501
Query: 407 GLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFP 466
GL +NK+Y+N K LRYG LM+MA+QD DG+H KGLLINF +SFWPSLLKV F+ FT P
Sbjct: 502 GLQQNKEYTNVKSLRYGHLMIMADQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFTTP 561
Query: 467 IIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYF 524
+I+ S N + + SF SM +YE WK+ LGN+A W+IKY +GL S+ QE REYF
Sbjct: 562 VIRASHPNKTIT------SFYSMPEYEAWKERLGNSATSWKIKYYKGLGTSTPQEGREYF 615
Query: 525 QDLGKHRAYFVWDDK-DETSIKLAFSKK-AEEWEAWIGNSQPGTC-NYERKVINYRNFVN 581
DLG+HR F+WDD+ D +I+LAFSKK AE + W+ N +PGTC ++E K+INY++FVN
Sbjct: 616 SDLGRHRKDFIWDDELDGNAIELAFSKKKAEGRKIWMRNFEPGTCRDHEAKLINYKDFVN 675
Query: 582 KELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHSYCHYG 641
KEL+ S R LF SF+ L K+ +V + YV+EHS H+G
Sbjct: 676 KELILFS-------------------RADLFGSFKKKLYKEIKVAQFIGYVSEHSAYHHG 716
Query: 642 QQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPV 701
+QS+ASTIIGMAQDFVGSNNINLL P GQFGT +LGGKDHAS+R +Y +L+ VTR LF
Sbjct: 717 EQSLASTIIGMAQDFVGSNNINLLKPNGQFGTCNLGGKDHASARYIYTELSPVTRCLFHE 776
Query: 702 DDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFL 761
DDKLLEYLNEDG+SI+PNWY+PIIPLVLVNG +GT +SS IP Y+P EII NVRR L
Sbjct: 777 HDDKLLEYLNEDGKSIEPNWYMPIIPLVLVNGSEGIGTGWSSYIPNYNPREIIANVRRLL 836
Query: 762 NNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKF 821
N EE+V M PWYKGF GTIEKSAK G Y V+G V I+EQTFRI ELPIR WT+DYK+F
Sbjct: 837 NGEELVPMDPWYKGFRGTIEKSAKE-GGYIVNGTVTEIDEQTFRITELPIRKWTQDYKQF 895
Query: 822 LEKITARG------LIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTIST 875
LE IT LIE FRQ GD IV+ ++ +K E+IATI E L KKF LT TIST
Sbjct: 896 LESITDGAPNVKDPLIEDFRQNGDDAIVDIEIKMKPEKIATI-LQEGLFKKFKLTSTIST 954
Query: 876 SNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISN 935
SNM+LFDAEG KK++TPEQILEEF LRL YY + K+Y++ N +LL L K +FI
Sbjct: 955 SNMHLFDAEGN-KKFDTPEQILEEFFPLRLDYYEKSKEYILGNLNRLLLILDNKVRFILG 1013
Query: 936 IVNEKFNPINR-RAELLIEIL--------KKGKSAEPHVAGAIDYSSKEQEAGEQESVSQ 986
+VN + NR +AELLIE+ +KGKS +P VAGA D S+EQE E E+ SQ
Sbjct: 1014 VVNGEIIVSNRKKAELLIELKEKGFTPMPRKGKSTKPQVAGANDDDSEEQEDAEPETASQ 1073
Query: 987 SVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLEL 1046
SVS+EGAT GDY+ L SLP TLES++KL E EKE E + L T +WL DL+
Sbjct: 1074 SVSVEGATWGDYDDLLSLPIGTLTLESVQKLLDEKTEKEKEYEILSGTPTTSLWLKDLDE 1133
Query: 1047 FEKEFD 1052
FEK+ D
Sbjct: 1134 FEKKLD 1139
>TOP2_ARATH (P30182) DNA topoisomerase II (EC 5.99.1.3)
Length = 1473
Score = 825 bits (2132), Expect = 0.0
Identities = 475/977 (48%), Positives = 626/977 (63%), Gaps = 57/977 (5%)
Query: 122 VSLCDNGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIP 180
++ C+ + WT V FKPDL KF+M LE DV+ALM KRV D+A CLG++V V LNG IP
Sbjct: 206 ITKCNKSENWTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIP 265
Query: 181 VKSFKDYANFFLDRAKPF----PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKG 236
VKSF DY + +L A PLPR K+ DR E+C+SLS+G+FQQVSFVNSIATIKG
Sbjct: 266 VKSFTDYVDLYLSAANKSRTEDPLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKG 325
Query: 237 GTHVDYITKQITTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTT 295
GTHVDY+T QIT +I V KK K+ NV A VKN LWVFVNALIDNPAF+SQTKE LT
Sbjct: 326 GTHVDYVTSQITNHIVAAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTL 385
Query: 296 KPARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-----------------DAK 337
+ + G K L V KS +++NLL FK + DA
Sbjct: 386 RQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVLVEKLDDAA 445
Query: 338 LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR-KLFKK 396
AG +S CTLILT+G K LA++G S V+ + GVFPL KLLN S ++
Sbjct: 446 EAGGKNSRLCTLILTEGDSAKSLALAGRS-VLGNNYCGVFPLRGKLLNVREASTTQITNN 504
Query: 397 KEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKV 456
KEI+NL ILGL +N KY N LRYGQ+M+M +QD DG+H KGLLINF +SFWPSLL+V
Sbjct: 505 KEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQV 564
Query: 457 SKFMSVFTFPIIKVSMYNASDSKKG--KELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
F+ F PI+K + +KG K LSF SM +YE+WK+ L A W+IKY +GL
Sbjct: 565 PSFLVEFITPIVKAT-------RKGTKKVLSFYSMPEYEEWKESLKGNATGWDIKYYKGL 617
Query: 515 --SSAQEVREYFQDLGKHRAYFVWDDK-DETSIKLAFSKKA-EEWEAWIGNSQPGTCNYE 570
S+A+E +EYF +LG H+ FVW+D+ D +I+LAFSKK E + W+ + PG +
Sbjct: 618 GTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSSYVPGNHLDQ 677
Query: 571 RKV-INYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLT 629
R+ + Y +FVNKEL+ SM +LQRSIPS+VDGL GQRK LF +F+ K+ +V +L
Sbjct: 678 RQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLV 737
Query: 630 AYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYI 689
YV+ S H+G+QS+AS IIGMAQD+VGSNNINLL+P GQFGTR GGKD AS+R ++
Sbjct: 738 GYVSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFT 797
Query: 690 KLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYH 749
KL+ VTR+LFP DDD LL+YLNEDG+ I+P WY+PIIP VLVNG +GT +S+ IP Y+
Sbjct: 798 KLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYN 857
Query: 750 PYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIG--YYTVDGLVERINEQTFRIK 807
P EI+ NVRR LN E MV M PWY+GF GTIEK+A G YT+ GL E ++E T RI
Sbjct: 858 PREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKEGGCTYTITGLYEEVDETTIRIT 917
Query: 808 ELPIRMWTEDYKKFLEKI-TARG--LIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELR 864
ELPIR W +DYK FL+ + T G + + D + V+F + + EE + E
Sbjct: 918 ELPIRRWNDDYKNFLQSLKTDNGAPFFQDVKAYNDEKSVDFDL-ILSEENMLAARQEGFL 976
Query: 865 KKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLR 924
KKF LT TI+TSNM+LFD +G IKKY TPEQILEEF LR +YY +RK+ +VKN L
Sbjct: 977 KKFKLTTTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELL 1036
Query: 925 SLRIKQKFISNIVNEKFNPINRRAELLIEIL---------KKGKSAEPHVAGAIDYSSKE 975
L K +FI +++ + R+ ++E L +K +S E +AGA+D + E
Sbjct: 1037 KLENKARFILAVLSGEIIVNKRKKADIVEDLRQKGFTPFPRKAESVEAAIAGAVDDDAAE 1096
Query: 976 QEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTS 1035
+ E+ V S +Y+YL ++ + T+E +++L A+ D+ + ++ T+
Sbjct: 1097 EP--EEILVDPESSSSYIPGSEYDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTT 1154
Query: 1036 PDLMWLNDLELFEKEFD 1052
P +WL+DLE +KE +
Sbjct: 1155 PKSLWLSDLESLDKELE 1171
>TOP2_PLAFK (P41001) DNA topoisomerase II (EC 5.99.1.3)
Length = 1398
Score = 630 bits (1626), Expect = e-180
Identities = 372/888 (41%), Positives = 537/888 (59%), Gaps = 63/888 (7%)
Query: 210 RLEICLSLSDG-KFQQVSFVNSIATIKGGTHVDYITKQITTYIKKEVLKKKH--VNVNAD 266
R EI +S SDG +FQQVSFVNSI T KGG+HV+YI +Q+ + + K+ K + + +
Sbjct: 330 RWEIVVSKSDGSQFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGGMEIKSG 389
Query: 267 TVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLK-FFPGSMLNDVQKSQILDNLLPR 325
++N LWVFVN LI NP F+SQTKE LTTKP + G K +N+V KS IL N+L
Sbjct: 390 HIRNHLWVFVNCLIVNPTFDSQTKETLTTKPVKFGSKCILSDKTINNVLKSPILSNILLW 449
Query: 326 IPFKHRTHV----------------------DAKLAGRPDSGKCTLILTQGQYVKDLAMS 363
K + + DA AG S +CTLILT+G K ++
Sbjct: 450 AQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLILTEGDSAKTSCLA 509
Query: 364 GLSAVVDPDLYGVFPLSSKLLNATRDS-RKLFKKKEIQNLMAILGL-VRNKKYSNAKCLR 421
GLS +V D YGVFPL KLLN S ++L KEIQN+ I+GL + +K + K LR
Sbjct: 510 GLS-IVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDITDKNKDDIKGLR 568
Query: 422 YGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKG 481
YG LM+M +QD DG+H KGLLIN + FWPSLLK F+S F PI+KV K
Sbjct: 569 YGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQ-------KGS 621
Query: 482 KELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSAQEVREYFQDLGKHRAYFVWD-D 538
+E SF ++ +YE WK+ W+IKY +GL S+ +E ++YF D+ H+ F+W D
Sbjct: 622 QEYSFFTIAEYEQWKENTNLLG--WKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGD 679
Query: 539 KDETSIKLAFSKKA-EEWEAWIGNSQPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSI 596
+D SI +AFSKK E+ + W+ N G+ +++ K ++Y +FVNKEL++ S + +RSI
Sbjct: 680 RDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSI 739
Query: 597 PSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVTEHS-YCHYGQQSIASTIIGMAQD 655
P+++DG GQRK L+ F+ NL + +V +L Y+ EHS Y H+G+ S+ TII MAQ
Sbjct: 740 PNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHHGESSLQQTIINMAQT 799
Query: 656 FVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGR 715
FVGSNNIN L P GQFG+R GGKD +++R ++ KL TR +F DD +L+YLNE+G+
Sbjct: 800 FVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQ 859
Query: 716 SIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKG 775
I+P +YIP+IP +LVNGC +GT +SS IP Y+ +II N++R++N E ++ M PWYK
Sbjct: 860 KIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKD 919
Query: 776 FGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITA---RGLIE 832
F G IE + K GY T+ G++ +I+ T I ELPI+ WT+DYK+FLE++ LI
Sbjct: 920 FKGRIESNGK-TGYETI-GIINKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLIL 977
Query: 833 SFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNT 892
+ +E + F + + ++ E +E L K F L T++T+NM LFD K+++Y+T
Sbjct: 978 DYIDNSSHEDICFTIKMDPAKLQKAE-EEGLEKVFKLKSTLTTTNMTLFDPNLKLQRYST 1036
Query: 893 PEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLI 952
IL+EFC RLK Y RK YL+ + R + K KFI IVN + ++ ++L+
Sbjct: 1037 ELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLV 1096
Query: 953 EILKKGKSAEPHVAGAIDYSS-KEQEAGEQESVSQSVS-------IEGATLGDYEYLSSL 1004
E L + K +P+ D + K++E EQE + + + I G T+ DY+YL S+
Sbjct: 1097 EELYR-KGYDPYK----DINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSM 1151
Query: 1005 PFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
P + TLE ++ L +L EKE EL+ L + + + MWL D+E E+ +
Sbjct: 1152 PIFSLTLEKVEDLLTQLKEKERELEILRNITVETMWLKDIEKVEEAIE 1199
Score = 54.3 bits (129), Expect = 2e-06
Identities = 31/68 (45%), Positives = 43/68 (62%), Gaps = 5/68 (7%)
Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
NGK + V FKPDL+KF M ++ D+ +L+ KRV D+A C +V V LNG + VK F
Sbjct: 193 NGKDYVKVTFKPDLNKFGMTEMDDDIESLLFKRVYDLAGTC---SVRVYLNGQRLAVKDF 249
Query: 185 KDYANFFL 192
K Y + +L
Sbjct: 250 KSYVDLYL 257
>TP2A_CRIGR (P41515) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3)
Length = 1526
Score = 620 bits (1600), Expect = e-177
Identities = 390/987 (39%), Positives = 569/987 (57%), Gaps = 80/987 (8%)
Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
NG+ +T + F+PDL KF M++L+KD++ALM +R D+A G T V V LNG +PVK
Sbjct: 209 NGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNKLPVKG 265
Query: 184 FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
F+ Y + +L D+ L H ++ R E+CL++S+ FQQ+SFVNSIAT KGG HV
Sbjct: 266 FRSYVDMYLKDKLDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHV 325
Query: 241 DYITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
DY+ QI + + +V+KKK+ V V A VKN +W+FVNALI+NP F+SQTKE +T +
Sbjct: 326 DYVADQIVSKLV-DVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQA 384
Query: 298 ARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAK 337
G + I++++L + FK + + DA
Sbjct: 385 KSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDAN 444
Query: 338 LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKK 396
AG +S +CTLILT+G K LA+SGL VV D YGVFPL K+LN S K + +
Sbjct: 445 DAGSRNSTECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKILNVREASHKQIMEN 503
Query: 397 KEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSL 453
EI N++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF + WPSL
Sbjct: 504 AEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 563
Query: 454 LKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQG 513
L+ +F+ F PI+KVS K +EL+F S+ ++E+WK N W++KY +G
Sbjct: 564 LR-HRFLEEFITPIVKVS-------KNKQELAFYSLPEFEEWKSSTPNHKK-WKVKYYKG 614
Query: 514 L--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKKA----EEW----------E 556
L S+++E +EYF D+ +HR F + +D+ +I LAFSKK +EW
Sbjct: 615 LGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTHFMEDRRQR 674
Query: 557 AWIGNSQPGTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFE 616
+G + + Y +F+NKEL+ S + +RSIPS+VDGL GQRK LF F+
Sbjct: 675 KLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFK 734
Query: 617 MNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDL 676
N ++ +V +L V E S H+G+ S+ TII +AQ+FVGSNN+NLL P GQFGTR
Sbjct: 735 RNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLH 794
Query: 677 GGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHA 736
GGKD AS R ++ L+ +TRLLFP DD L++L +D + ++P WYIPIIP+VL+NG
Sbjct: 795 GGKDSASPRYIFTMLSPLTRLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEG 854
Query: 737 MGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLV 796
+GT +S IP + E++ N+RR L+ EE + M P YK F GTIE+ A Y ++G V
Sbjct: 855 IGTGWSCKIPNFDIREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELAS--NQYVINGEV 912
Query: 797 ERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVNVK 850
+N T I ELPIR WT+ YK+ + + G LI +R+ V F + +
Sbjct: 913 AILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMT 972
Query: 851 QEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVR 910
+E++A E+ L K F L +++ ++M LFD G +KKY+T IL++F LRLKYY
Sbjct: 973 EEKLAEAER-VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILKDFFELRLKYYGL 1031
Query: 911 RKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVAGAI 969
RK++L+ L + +FI ++ K N+ + EL+ ++++G ++P A
Sbjct: 1032 RKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKE 1091
Query: 970 DYSSKEQEAGEQES---VSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKEN 1026
E +ES S SV+ G T + YL +P T E +L + +EKE
Sbjct: 1092 AQQKVPDEEENEESDNENSDSVAESGPT---FNYLLDMPLWYLTKEKKDELCKQRNEKEQ 1148
Query: 1027 ELKTLEHTSPDLMWLNDLELFEKEFDV 1053
EL TL++ SP +W DL +F +E +V
Sbjct: 1149 ELNTLKNKSPSDLWKEDLAVFIEELEV 1175
>TP2A_CHICK (O42130) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3)
Length = 1553
Score = 620 bits (1598), Expect = e-177
Identities = 394/988 (39%), Positives = 569/988 (56%), Gaps = 88/988 (8%)
Query: 126 DNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
D +T V F+PDL KF M L+KD++ALM +R D+A G T V V LNG +PVK
Sbjct: 211 DGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIA---GSTKDVKVFLNGKRLPVKG 267
Query: 184 FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
F+ Y + +L D+ L H ++ R E+CL+LS+ FQQVSFVNSIAT KGG HV
Sbjct: 268 FRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEKGFQQVSFVNSIATTKGGRHV 327
Query: 241 DYITKQITTYIKKEVLKKKHVN---VNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
DY+ QI T + +V+KKK+ N V VKN +W+FVN+LI+NP F+SQTKE +T +
Sbjct: 328 DYVADQIVTKLI-DVVKKKNKNGVGVKPFQVKNHMWIFVNSLIENPTFDSQTKENMTLQA 386
Query: 298 ------ARLGLKFFPGSMLNDVQKSQILDNLLPRIPFKHRTHV----------------- 334
+L KF G++ I++++L + FK +T +
Sbjct: 387 KSFGSTCKLSEKFIKGAV-----GCGIVESILNWVKFKAQTQLNKKCSAVKHTKIKGVPK 441
Query: 335 --DAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK 392
DA AG +S CTLILT+G K LA+SGL VV D YGVFPL K+LN S K
Sbjct: 442 LDDANDAGSKNSIDCTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKMLNVREASHK 500
Query: 393 -LFKKKEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYS 448
+ + EI N++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF +
Sbjct: 501 QIMENAEINNIIKIVGLQYKKNYEDRESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHH 560
Query: 449 FWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEI 508
WPSLL+ F+ F PIIKVS K +E+ F S+ ++E+WK N N W+I
Sbjct: 561 NWPSLLR-HNFLEEFITPIIKVS-------KNKEEIPFYSIPEFEEWKSSTQNY-NSWKI 611
Query: 509 KYCQGL--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKK-AEEWEAWIGNSQ- 563
KY +GL S+++E +EYF D+ +HR F + +D+ +I LAFSKK EE + W+ N
Sbjct: 612 KYYKGLGTSTSKEAKEYFADMARHRIGFKYSGPEDDAAITLAFSKKKVEERKEWLTNFME 671
Query: 564 ----------PGTCNY--ERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTL 611
P Y + + Y +F+NKEL+ S + +RSIPS+VDGL GQRK L
Sbjct: 672 DRRQRNVHGLPEDYLYGKDTNYLTYNDFINKELVLFSNSDNERSIPSLVDGLKPGQRKVL 731
Query: 612 FCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQF 671
F F+ N ++ + +L V E S H+G+ S+ TII +AQ+FVGSNN+NLL P GQF
Sbjct: 732 FTCFKRNDKREVKGAQLAGSVAEMSSYHHGEASLMMTIINLAQNFVGSNNLNLLQPIGQF 791
Query: 672 GTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLV 731
GTR GGKD AS R ++ L+ + RLLFP DD +L +L +D + ++P WY+PIIP+VL+
Sbjct: 792 GTRLHGGKDSASPRYIFTMLSPLARLLFPPVDDNVLRFLYDDNQRVEPEWYMPIIPMVLI 851
Query: 732 NGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYT 791
NG +GT +S IP + E + N+R L+ +E + M P YK F GTI++ G Y
Sbjct: 852 NGAEGIGTGWSCKIPNFDIRETVNNIRCLLDGKEPLPMLPSYKNFKGTIDE--LGPNQYV 909
Query: 792 VDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNF 845
+ G V ++ T I ELP+R WT+ YK+ + + G LI +++ V F
Sbjct: 910 ISGEVSILDSTTIEITELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYKEYHTDTTVKF 969
Query: 846 KVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRL 905
V + +E++A E L K F L ++ ++M LFD G +KKY +P+ IL+EF LRL
Sbjct: 970 VVKMSEEKLAEAEA-VGLHKVFKLQTNLTCNSMVLFDHVGFLKKYESPQDILKEFFELRL 1028
Query: 906 KYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPH 964
+YY RK++L+ L + +FI ++ K N+ + LI++L ++G ++P
Sbjct: 1029 RYYGLRKEWLIGMLGAESAKLNNQARFILEKIDGKIVIENKPKKELIQVLIQRGYESDP- 1087
Query: 965 VAGAIDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEK 1024
V + +KE+E G+ ES +S + AT D+ YL ++P T E +L + D K
Sbjct: 1088 VKAWKELQNKEEEEGD-ESGEESAA---ATGPDFNYLLNMPLWYLTKEKKDELCKQRDNK 1143
Query: 1025 ENELKTLEHTSPDLMWLNDLELFEKEFD 1052
+ EL+ L+H SP +W DL F +E D
Sbjct: 1144 DKELEDLKHKSPSDLWKEDLAAFVEELD 1171
>TP2A_HUMAN (P11388) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3)
Length = 1531
Score = 618 bits (1593), Expect = e-176
Identities = 391/992 (39%), Positives = 570/992 (57%), Gaps = 88/992 (8%)
Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
NG+ +T + F+PDL KF M++L+KD++ALM +R D+A G T V V LNG +PVK
Sbjct: 210 NGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNKLPVKG 266
Query: 184 FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
F+ Y + +L D+ L H ++ R E+CL++S+ FQQ+SFVNSIAT KGG HV
Sbjct: 267 FRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHV 326
Query: 241 DYITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKP 297
DY+ QI T + +V+KKK+ V V A VKN +W+FVNALI+NP F+SQTKE +T +P
Sbjct: 327 DYVADQIVTKLV-DVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQP 385
Query: 298 ARLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAK 337
G + I++++L + FK + + DA
Sbjct: 386 KSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDAN 445
Query: 338 LAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKK 396
AG +S +CTLILT+G K LA+SGL VV D YGVFPL K+LN S K + +
Sbjct: 446 DAGGRNSTECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKILNVREASHKQIMEN 504
Query: 397 KEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSL 453
EI N++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF + WPSL
Sbjct: 505 AEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 564
Query: 454 LKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQG 513
L+ +F+ F PI+KVS K +E++F S+ ++E+WK N W++KY +G
Sbjct: 565 LR-HRFLEEFITPIVKVS-------KNKQEMAFYSLPEFEEWKSSTPNHKK-WKVKYYKG 615
Query: 514 L--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKKA-EEWEAWIGNSQPGTCNY 569
L S+++E +EYF D+ +HR F + +D+ +I LAFSKK ++ + W+ N
Sbjct: 616 LGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMED--RR 673
Query: 570 ERKVIN---------------YRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCS 614
+RK++ Y +F+NKEL+ S + +RSIPS+VDGL GQRK LF
Sbjct: 674 QRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 733
Query: 615 FEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTR 674
F+ N ++ +V +L V E S H+G+ S+ TII +AQ+FVGSNN+NLL P GQFGTR
Sbjct: 734 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTR 793
Query: 675 DLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGC 734
GGKD AS R ++ L+ + RLLFP DD L++L +D + ++P WYIPIIP+VL+NG
Sbjct: 794 LHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGA 853
Query: 735 HAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDG 794
+GT +S IP + EI+ N+RR ++ EE + M P YK F GTIE+ A Y + G
Sbjct: 854 EGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAP--NQYVISG 911
Query: 795 LVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVN 848
V +N T I ELP+R WT+ YK+ + + G LI +R+ V F V
Sbjct: 912 EVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVK 971
Query: 849 VKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYY 908
+ +E++A E+ L K F L +++ ++M LFD G +KKY+T IL +F LRLKYY
Sbjct: 972 MTEEKLAEAER-VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYY 1030
Query: 909 VRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVA- 966
RK++L+ L + +FI ++ K N+ + EL+ ++++G ++P A
Sbjct: 1031 GLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAW 1090
Query: 967 -----GAIDYSSKEQEAGEQES-VSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAE 1020
D E+ E+E+ S SV+ G T + YL +P T E +L
Sbjct: 1091 KEAQQKVPDEEENEESDNEKETEKSDSVTDSGPT---FNYLLDMPLWYLTKEKKDELCRL 1147
Query: 1021 LDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
+EKE EL TL+ SP +W DL F +E +
Sbjct: 1148 RNEKEQELDTLKRKSPSDLWKEDLATFIEELE 1179
>TP2B_MOUSE (Q64511) DNA topoisomerase II, beta isozyme (EC 5.99.1.3)
Length = 1612
Score = 617 bits (1590), Expect = e-176
Identities = 385/986 (39%), Positives = 556/986 (56%), Gaps = 78/986 (7%)
Query: 126 DNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
D +T + F+PDL KF M+ L+KD++ALM +R D+A C G V V+ NG +PV F
Sbjct: 219 DGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKG--VKVMFNGKKLPVNGF 276
Query: 185 KDYANFFL-DRAKP--FPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVD 241
+ Y + ++ D+ L H +R ++CL+LS+ FQQ+SFVNSIAT KGG HVD
Sbjct: 277 RSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVD 336
Query: 242 YITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPA 298
Y+ Q+ + + EV+KKK+ V+V VKN +WVF+N LI+NP F+SQTKE +T +P
Sbjct: 337 YVVDQVVSKLI-EVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPK 395
Query: 299 RLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKL 338
G K I++++L + FK +T + DA
Sbjct: 396 SFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDAND 455
Query: 339 AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKK 397
AG S +CTLILT+G K LA+SGL V+ D YGVFPL K+LN S K + +
Sbjct: 456 AGGKHSLECTLILTEGDSAKSLAVSGLG-VIGRDRYGVFPLRGKILNVREASHKQIMENA 514
Query: 398 EIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLL 454
EI N++ I+GL K Y +A K LRYG++M+M +QD+DG+H KGLLINF + WPSLL
Sbjct: 515 EINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 574
Query: 455 KVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
K F+ F PI+K S K +ELSF S+ ++++WKK + N W+IKY +GL
Sbjct: 575 KHG-FLEEFITPIVKAS-------KNKQELSFYSIPEFDEWKKHIENQ-KAWKIKYYKGL 625
Query: 515 --SSAQEVREYFQDLGKHRAYFVW-DDKDETSIKLAFSKKA-EEWEAWIGNSQP------ 564
S+A+E +EYF D+ +HR F + +D+ +I LAFSKK ++ + W+ N
Sbjct: 626 GTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR 685
Query: 565 ----------GTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCS 614
GT K + Y +F+NKEL+ S + +RSIPS+VDG GQRK LF
Sbjct: 686 LHGLPEQFLYGTAT---KHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTC 742
Query: 615 FEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTR 674
F+ N ++ +V +L V E S H+G+Q++ TI+ +AQ+FVGSNNINLL P GQFGTR
Sbjct: 743 FKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTR 802
Query: 675 DLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGC 734
GGKD AS R ++ L+ + RLLFP DD LL++L +D + ++P WYIPIIP+VL+NG
Sbjct: 803 LHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGA 862
Query: 735 HAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDG 794
+GT ++ +P Y EI+ NVRR L + M P YK F GTI++ G Y V G
Sbjct: 863 EGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQE--LGQNQYAVSG 920
Query: 795 LVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVN 848
+ ++ T I ELP+R WT+ YK+ + + G LI +++ V F V
Sbjct: 921 EIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVK 980
Query: 849 VKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYY 908
+ +E++A E L K F L T++ ++M LFD G +KKY T + IL+EF LRL YY
Sbjct: 981 MTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYY 1039
Query: 909 VRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPHVAG 967
RK++LV L + +FI + K NR + LI++L ++G ++P A
Sbjct: 1040 GLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAW 1099
Query: 968 AIDYSSKEQEAGEQESVSQSVSIEGATLG-DYEYLSSLPFENFTLESLKKLEAELDEKEN 1026
+E Q S S G G D+ Y+ ++ + T E +++L + D K
Sbjct: 1100 KEAQEKAAEEEDSQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGR 1159
Query: 1027 ELKTLEHTSPDLMWLNDLELFEKEFD 1052
E+ L+ SP +W DL F +E D
Sbjct: 1160 EVNDLKRKSPSDLWKEDLAAFVEELD 1185
>TOP2_SCHPO (P08096) DNA topoisomerase II (EC 5.99.1.3)
Length = 1485
Score = 617 bits (1590), Expect = e-176
Identities = 383/968 (39%), Positives = 558/968 (57%), Gaps = 63/968 (6%)
Query: 123 SLCDNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVK 182
SL ++T + FKPDL KF M ++ D+++++K+R+ DMA + ET V LN I +
Sbjct: 253 SLKKPDEYTKITFKPDLAKFGMDKIDDDMVSIIKRRIYDMAGTVRET-KVYLNNERISIS 311
Query: 183 SFKDYANFFL--DRAKPFPLPRT-HAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTH 239
FK Y +L D PR + + DR ++ ++SDG+F+QVSFVN+I+TI+GGTH
Sbjct: 312 GFKKYVEMYLASDTKPDEEPPRVIYEHVNDRWDVAFAVSDGQFKQVSFVNNISTIRGGTH 371
Query: 240 VDYITKQITTYIKKEVLKK-KHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPA 298
V+Y+ +I I + V K+ K V A +KN + VFVN I+NP+F+SQTKE LTTK +
Sbjct: 372 VNYVANKIVDAIDEVVKKENKKAPVKAFQIKNYVQVFVNCQIENPSFDSQTKETLTTKVS 431
Query: 299 RLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV------------------DAKLA 339
G + L ++KS +++ +L K + DA A
Sbjct: 432 AFGSQCTLSDKFLKAIKKSSVVEEVLKFATAKADQQLSKGDGGLRSRITGLTKLEDANKA 491
Query: 340 GRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR-KLFKKKE 398
G +S KC LILT+G K LA+SGLS VV D YGVFPL KLLN S ++ KE
Sbjct: 492 GTKESHKCVLILTEGDSAKSLAVSGLS-VVGRDYYGVFPLRGKLLNVREASHSQILNNKE 550
Query: 399 IQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSK 458
IQ + I+G K Y++ K LRYG LM+M +QD DG+H KGL+IN+ S +PSLL++
Sbjct: 551 IQAIKKIMGFTHKKTYTDVKGLRYGHLMIMTDQDHDGSHIKGLIINYLESSYPSLLQIPG 610
Query: 459 FMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGLSSAQ 518
F+ F PIIK + N + F ++ +YE WK E N W+IKY +GL ++
Sbjct: 611 FLIQFITPIIKCTRGNQVQA-------FYTLPEYEYWK-EANNNGRGWKIKYYKGLGTSD 662
Query: 519 --EVREYFQDLGKHRAYF-VWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGT-CNYERKV 573
+++ YF DL +H YF +KD I++AF+KK A+ + W+ +PG +Y +
Sbjct: 663 HDDMKSYFSDLDRHMKYFHAMQEKDAELIEMAFAKKKADVRKEWLRTYRPGIYMDYTQPQ 722
Query: 574 INYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAYVT 633
I +F+N+EL+ SM + RSIPSVVDGL GQRK ++ F+ NL +T+V RL YV
Sbjct: 723 IPIDDFINRELIQFSMADNIRSIPSVVDGLKPGQRKVVYYCFKRNLVHETKVSRLAGYVA 782
Query: 634 EHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKLNC 693
+ H+G+ S+ TI+ +AQ+FVGSNNINLL+P GQFGTR GGK+ ++SR L L+
Sbjct: 783 SETAYHHGEVSMEQTIVNLAQNFVGSNNINLLMPNGQFGTRSEGGKNASASRYLNTALSP 842
Query: 694 VTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPYEI 753
+ R+LF +DD+LL Y N++G+ I+P +Y+PI+P+VLVNG +GT +S+ IP Y+P +I
Sbjct: 843 LARVLFNSNDDQLLNYQNDEGQWIEPEYYVPILPMVLVNGAEGIGTGWSTFIPNYNPKDI 902
Query: 754 IKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPIRM 813
N+R LN E + M PWY+GF G+I K A Y + G++ +I E I ELPIR
Sbjct: 903 TANLRHMLNGEPLEIMTPWYRGFRGSITKVAP--DRYKISGIINQIGENKVEITELPIRF 960
Query: 814 WTEDYKKFLEKITARGLIESFRQKG---DYEI----VNFKVNVKQEEIATIEK-DEELRK 865
WT+D K++LE GL+ + + + DYE N NV E E +E L
Sbjct: 961 WTQDMKEYLE----AGLVGTEKIRKFIVDYESHHGEGNVHFNVTLTEAGMKEALNESLEV 1016
Query: 866 KFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRS 925
KF L+ T +TSNM FDA G+IKKY++ E IL EF +RL+ Y RRK+++V +
Sbjct: 1017 KFKLSRTQATSNMIAFDASGRIKKYDSVEDILTEFYEVRLRTYQRRKEHMVNELEKRFDR 1076
Query: 926 LRIKQKFISNIVNEKFNPINRRAELLIEILKKGK---SAEPHVAGAIDYSSKEQEAGEQE 982
+ +FI I+ + ++ + LI LK+ K ++P +D + A E++
Sbjct: 1077 FSNQARFIHMIIEGELVVSKKKKKDLIVELKEKKFQPISKPKKGHLVDLEVENALAEEEQ 1136
Query: 983 S--VSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMW 1040
S VSQ + Y YL S+P + T E +L + DE EL L +P +W
Sbjct: 1137 SGDVSQDEDSDA-----YNYLLSMPLWSLTYERYVELLKKKDEVMAELDALIKKTPKELW 1191
Query: 1041 LNDLELFE 1048
L+DL+ FE
Sbjct: 1192 LHDLDAFE 1199
>TOP2_YEAST (P06786) DNA topoisomerase II (EC 5.99.1.3)
Length = 1428
Score = 616 bits (1588), Expect = e-175
Identities = 371/983 (37%), Positives = 557/983 (55%), Gaps = 77/983 (7%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
+T V FKPDL +F MK L+ D++ +M++RV D+ + + + V LNG + +++FK+Y
Sbjct: 194 YTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRD-INVYLNGKSLKIRNFKNYVE 252
Query: 190 FFL-------------DRAKPFPLPRT-HAKLGDRLEICLSLSDGKFQQVSFVNSIATIK 235
+L D A +P + ++ +R E+ ++SD FQQ+SFVNSIAT
Sbjct: 253 LYLKSLEKKRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTM 312
Query: 236 GGTHVDYITKQITTYIKKEVLKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTT 295
GGTHV+YIT QI I + + KKK +V + +KN +++F+N LI+NPAF SQTKE LTT
Sbjct: 313 GGTHVNYITDQIVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTT 372
Query: 296 KPARLGLKF-FPGSMLNDVQKSQIL-----------DNLLPRIPFKHRTHV-------DA 336
+ G + P +N + K+ + +N L + ++ + DA
Sbjct: 373 RVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEENALKKSDGTRKSRITNYPKLEDA 432
Query: 337 KLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR-KLFK 395
AG + KCTL+LT+G LA++GL AVV D YG +PL K+LN S ++ K
Sbjct: 433 NKAGTKEGYKCTLVLTEGDSALSLAVAGL-AVVGRDYYGCYPLRGKMLNVREASADQILK 491
Query: 396 KKEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLK 455
EIQ + I+GL KKY + K LRYG LM+M +QD DG+H KGL+INF S +P LL
Sbjct: 492 NAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLD 551
Query: 456 VSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL- 514
+ F+ F PIIKVS+ + + ++F +M YE W++E + W+ KY +GL
Sbjct: 552 IQGFLLEFITPIIKVSITKPTKNT----IAFYNMPDYEKWREEESHKFT-WKQKYYKGLG 606
Query: 515 -SSAQEVREYFQDLGKH-RAYFVWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGTC-NYE 570
S AQEVREYF +L +H + + D+ I LAFSKK A++ + W+ +PGT +
Sbjct: 607 TSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGTVLDPT 666
Query: 571 RKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTA 630
K I +F+NKEL+ S+ + RSIP+V+DG GQRK L+ F+ NL + +V +L
Sbjct: 667 LKEIPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAP 726
Query: 631 YVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIK 690
YV+E + H+G+QS+A TIIG+AQ+FVGSNNI LL+P G FGTR GGKD A++R +Y +
Sbjct: 727 YVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTE 786
Query: 691 LNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHP 750
LN +TR +F DD L +Y+ ED ++++P WY+PI+P++LVNG +GT +S+ IP ++P
Sbjct: 787 LNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNP 846
Query: 751 YEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELP 810
EIIKN+R +N+EE+ M PW++G+ GTIE+ Y + G +E+I + I ELP
Sbjct: 847 LEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEP--LRYRMYGRIEQIGDNVLEITELP 904
Query: 811 IRMWTEDYKKFL-------EKITARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEEL 863
R WT K++L +KI + I+ ++ D + + F + + EE+A K
Sbjct: 905 ARTWTSTIKEYLLLGLSGNDKI--KPWIKDMEEQHD-DNIKFIITLSPEEMAKTRK-IGF 960
Query: 864 RKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLL 923
++F L IS NM FD GKIKKYN+ +IL EF +RL+YY +RK ++ + +
Sbjct: 961 YERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEV 1020
Query: 924 RSLRIKQKFISNIVNEKFNPINRRAELLIEILKK------GKSAEPHVAGAID------- 970
+ KFI I+ ++ N+ +I+ L+ K +P+ D
Sbjct: 1021 EKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQIN 1080
Query: 971 -----YSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKE 1025
S +E E E ++ G YEYL + + T E +KL + EKE
Sbjct: 1081 DVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKE 1140
Query: 1026 NELKTLEHTSPDLMWLNDLELFE 1048
EL+ L S +W DL+ FE
Sbjct: 1141 TELENLLKLSAKDIWNTDLKAFE 1163
>TP2B_CHICK (O42131) DNA topoisomerase II, beta isozyme (EC 5.99.1.3)
Length = 1627
Score = 615 bits (1587), Expect = e-175
Identities = 385/982 (39%), Positives = 559/982 (56%), Gaps = 78/982 (7%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSFKDYA 188
+T + F+PDL KF M+NL+KD+++LM +R D+A C G V V+LNG +PV F+ Y
Sbjct: 240 YTCITFQPDLSKFKMENLDKDIVSLMTRRAYDLAGSCKG--VKVMLNGKKLPVNGFRSYV 297
Query: 189 NFFL-DRAKP--FPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITK 245
+ ++ D+ L H + +R ++CL+LS+ FQQ+SFVNSIAT KGG HVDY+
Sbjct: 298 DLYVKDKLDETGVALKVIHEVVNERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVD 357
Query: 246 QITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGL 302
Q+ + EV+KKK+ V+V VKN +WVFVN LI+NP+F+SQTKE +T +P G
Sbjct: 358 QVVGKLI-EVVKKKNKAGVSVKPFQVKNHIWVFVNCLIENPSFDSQTKENMTLQPKSFGS 416
Query: 303 KF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKLAGRP 342
K I++++L + FK +T + DA AG
Sbjct: 417 KCQLSEKFFKAASNCGIIESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGK 476
Query: 343 DSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQN 401
S CTLILT+G K LA+SGL V+ D YGVFPL K+LN S K + + EI N
Sbjct: 477 HSLDCTLILTEGDSAKSLAVSGLG-VIGRDRYGVFPLRGKILNVREASHKQIMENAEINN 535
Query: 402 LMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSK 458
++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF + WPSLLK
Sbjct: 536 IIKIVGLQYKKSYEDPESLKSLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHG- 594
Query: 459 FMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SS 516
F+ F PI+K S K +ELSF S+ ++++WKK + N W+IKY +GL S+
Sbjct: 595 FLEEFITPIVKAS-------KNKQELSFYSIPEFDEWKKHMENH-KAWKIKYYKGLGTST 646
Query: 517 AQEVREYFQDLGKHRAYFVW-DDKDETSIKLAFSKKA-EEWEAWIGNSQP---------- 564
A+E +EYF D+ +HR F + +D+ +I LAFSKK ++ + W+ N
Sbjct: 647 AKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGL 706
Query: 565 ------GTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMN 618
GT K + Y +F+NKEL+ S + +RSIPS+VDGL GQRK LF F+ N
Sbjct: 707 PEQFLYGTAT---KHLTYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCFKRN 763
Query: 619 LTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGG 678
++ +V +L V E S H+G+Q++ TI+ +AQ+FVGSNN+NLL P GQFGTR GG
Sbjct: 764 DKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNLLQPIGQFGTRLHGG 823
Query: 679 KDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMG 738
KD AS R ++ L+ + RLLFP DD LL++L +D + ++P WYIPIIP+VLVNG +G
Sbjct: 824 KDAASPRYIFTMLSPLARLLFPSVDDNLLKFLYDDNQRVEPEWYIPIIPMVLVNGAEGIG 883
Query: 739 TCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVER 798
T ++ +P Y EI+ NVRR L+ + M P YK F GTI++ G Y V G +
Sbjct: 884 TGWACKLPNYDTREIVNNVRRMLDGLDPHPMLPNYKNFRGTIQE--LGQNQYVVSGEIFV 941
Query: 799 INEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVNVKQE 852
++ T I ELP+R WT+ YK+ + + G LI +++ V F V + +E
Sbjct: 942 VDRNTVEITELPVRTWTQVYKEQVLEPMLNGTEKTPALISDYKEYHTDTTVKFVVKMTEE 1001
Query: 853 EIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRK 912
++A E L K F L +++ ++M LFD G +KKY T + IL+EF LRL YY RK
Sbjct: 1002 KLAQAEA-AGLHKVFKLQTSLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLHYYSLRK 1060
Query: 913 QYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPHVAGAIDY 971
++LV L + +FI + K NR LI++L ++G ++P A
Sbjct: 1061 EWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKRDLIQMLVQRGYESDPVKAWKEAQ 1120
Query: 972 SSKEQEAGEQESVSQSVSIEGATLG-DYEYLSSLPFENFTLESLKKLEAELDEKENELKT 1030
+E Q + + S G+T G D+ Y+ ++ + T E +++L D KE EL
Sbjct: 1121 EKAAEEEDPQNANDDASSASGSTSGPDFNYILNMSLWSLTKEKVEELIKHRDSKERELND 1180
Query: 1031 LEHTSPDLMWLNDLELFEKEFD 1052
L+ S +W DL F +E +
Sbjct: 1181 LKRKSASDLWKEDLAAFVEELE 1202
>TP2A_RAT (P41516) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3)
Length = 1526
Score = 615 bits (1586), Expect = e-175
Identities = 382/985 (38%), Positives = 566/985 (56%), Gaps = 80/985 (8%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKSFKDY 187
+T + F+PDL KF M++L+KD++ALM +R D+A G T V V LNG +PVK F+ Y
Sbjct: 212 YTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNRLPVKGFRSY 268
Query: 188 ANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYIT 244
+ +L D+ L H ++ R E+CL++S+ FQQ+SFVNSIAT KGG HVDY+
Sbjct: 269 VDMYLKDKVDETGNALKVVHEQVNPRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVA 328
Query: 245 KQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLG 301
QI + + +V+KKK+ V V AD VKN +W+F NA+I+NP F+SQTKE +T + G
Sbjct: 329 DQIVSKLV-DVVKKKNKGGVAVKADQVKNHMWIFGNAVIENPTFDSQTKENMTLQAKSFG 387
Query: 302 LKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKLAGR 341
+ I++++L + FK + + DA AG
Sbjct: 388 STCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHNRIKGIPKLDDANDAGS 447
Query: 342 PDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQ 400
+S +CTLILT+G K LA+SGL VV D YGVFPL K+LN S K + + EI
Sbjct: 448 RNSAECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKILNVREASHKQIMENAEIN 506
Query: 401 NLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVS 457
N++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF + WPSLL+
Sbjct: 507 NIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-H 565
Query: 458 KFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--S 515
+F+ F PI+KVS K +E++F S+ ++E+WK N W++KY +GL S
Sbjct: 566 RFLEEFITPIVKVS-------KNKQEIAFYSLPEFEEWKSTNPNHKK-WKVKYYKGLGTS 617
Query: 516 SAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKK-AEEWEAWIGNSQPGTCNYERKV 573
+++E +EYF ++ +HR F + +D+ +I LAFSKK ++ + W+ N +RK+
Sbjct: 618 TSKEAKEYFANMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMED--RRQRKL 675
Query: 574 IN---------------YRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMN 618
+ Y +F+NKEL+ S + +RSIPS+VDGL GQRK LF F+ N
Sbjct: 676 LGLPEDYLYGQTTMYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRN 735
Query: 619 LTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGG 678
++ +V +L V E S H+G+ S+ TII +AQ+FVGSNN+NLL P GQFGTR GG
Sbjct: 736 DKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGG 795
Query: 679 KDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMG 738
KD AS R ++ L+ + RLLFP DD L +L +D + ++P WYIPIIP+VL+NG +G
Sbjct: 796 KDSASPRYIFTMLSPLARLLFPSKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIG 855
Query: 739 TCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVER 798
T +S IP + E++ N+RR L+ EE + M P YK + GTIE+ A Y ++G V
Sbjct: 856 TGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNYKGTIEELAS--NQYVINGEVAI 913
Query: 799 INEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVNVKQE 852
+N T I ELPIR WT+ YK+ + + G LI +R+ V F + + +E
Sbjct: 914 LNSTTIEITELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVIKMTEE 973
Query: 853 EIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRK 912
++A E+ L K F L +++ ++M LFD G +KKY+T IL +F LRLKYY RK
Sbjct: 974 KLAEAER-VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRK 1032
Query: 913 QYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVA---GA 968
++L+ L + +FI ++ K N+ + EL+ ++++G ++P A
Sbjct: 1033 EWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQ 1092
Query: 969 IDYSSKEQEAGEQESVSQSVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENEL 1028
+E+ +ES S+S S + + YL +P T E +L + DEKE EL
Sbjct: 1093 QKVPEEEENEENEESESESTSPAAESGPTFNYLLDMPLWYLTKEKKDELCKQRDEKEQEL 1152
Query: 1029 KTLEHTSPDLMWLNDLELFEKEFDV 1053
TL+ +P +W DL F +E +V
Sbjct: 1153 NTLKKKTPSDLWKEDLAAFVEELEV 1177
>TP2B_HUMAN (Q02880) DNA topoisomerase II, beta isozyme (EC 5.99.1.3)
Length = 1626
Score = 615 bits (1585), Expect = e-175
Identities = 385/986 (39%), Positives = 556/986 (56%), Gaps = 78/986 (7%)
Query: 126 DNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
D +T + F+PDL KF M+ L+KD++ALM +R D+A C G V V+ NG +PV F
Sbjct: 231 DGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRG--VKVMFNGKKLPVNGF 288
Query: 185 KDYANFFL-DRAKP--FPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVD 241
+ Y + ++ D+ L H +R ++CL+LS+ FQQ+SFVNSIAT KGG HVD
Sbjct: 289 RSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVD 348
Query: 242 YITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPA 298
Y+ Q+ + EV+KKK+ V+V VKN +WVF+N LI+NP F+SQTKE +T +P
Sbjct: 349 YVVDQVVGKLI-EVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPK 407
Query: 299 RLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKL 338
G K I++++L + FK +T + DA
Sbjct: 408 SFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDAND 467
Query: 339 AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKK 397
AG S +CTLILT+G K LA+SGL V+ D YGVFPL K+LN S K + +
Sbjct: 468 AGGKHSLECTLILTEGDSAKSLAVSGLG-VIGRDRYGVFPLRGKILNVREASHKQIMENA 526
Query: 398 EIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLL 454
EI N++ I+GL K Y +A K LRYG++M+M +QD+DG+H KGLLINF + WPSLL
Sbjct: 527 EINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 586
Query: 455 KVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
K F+ F PI+K S K +ELSF S+ ++++WKK + N W+IKY +GL
Sbjct: 587 KHG-FLEEFITPIVKAS-------KNKQELSFYSIPEFDEWKKHIENQ-KAWKIKYYKGL 637
Query: 515 --SSAQEVREYFQDLGKHRAYFVW-DDKDETSIKLAFSKKA-EEWEAWIGNSQP------ 564
S+A+E +EYF D+ +HR F + +D+ +I LAFSKK ++ + W+ N
Sbjct: 638 GTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR 697
Query: 565 ----------GTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCS 614
GT K + Y +F+NKEL+ S + +RSIPS+VDG GQRK LF
Sbjct: 698 LHGLPEQFLYGTAT---KHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTC 754
Query: 615 FEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTR 674
F+ N ++ +V +L V E S H+G+Q++ TI+ +AQ+FVGSNNINLL P GQFGTR
Sbjct: 755 FKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTR 814
Query: 675 DLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGC 734
GGKD AS R ++ L+ + RLLFP DD LL++L +D + ++P WYIPIIP+VL+NG
Sbjct: 815 LHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGA 874
Query: 735 HAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDG 794
+GT ++ +P Y EI+ NVRR L+ + M P YK F GTI++ G Y V G
Sbjct: 875 EGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQE--LGQNQYAVSG 932
Query: 795 LVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVN 848
+ ++ T I ELP+R WT+ YK+ + + G LI +++ V F V
Sbjct: 933 EIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVK 992
Query: 849 VKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYY 908
+ +E++A E L K F L T++ ++M LFD G +KKY T + IL+EF LRL YY
Sbjct: 993 MTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYY 1051
Query: 909 VRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPHVAG 967
RK++LV L + +FI + K NR + LI++L ++G ++P A
Sbjct: 1052 GLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAW 1111
Query: 968 AIDYSSKEQEAGEQESVSQSVSIEGATLG-DYEYLSSLPFENFTLESLKKLEAELDEKEN 1026
+E Q S S G G D+ Y+ ++ + T E +++L + D K
Sbjct: 1112 KEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGR 1171
Query: 1027 ELKTLEHTSPDLMWLNDLELFEKEFD 1052
E+ L+ SP +W DL F +E D
Sbjct: 1172 EVNDLKRKSPSDLWKEDLAAFVEELD 1197
>TP2B_CRILO (Q64399) DNA topoisomerase II, beta isozyme (EC 5.99.1.3)
Length = 1612
Score = 614 bits (1584), Expect = e-175
Identities = 385/986 (39%), Positives = 556/986 (56%), Gaps = 78/986 (7%)
Query: 126 DNGKWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMA-VCLGETVTVVLNGTVIPVKSF 184
D +T + F+PDL KF M+ L+KD++ALM +R D+A C G V V+ NG +PV F
Sbjct: 219 DGEDYTCITFQPDLAKFKMEKLDKDIVALMTRRAYDLAGSCKG--VKVMFNGKKLPVNGF 276
Query: 185 KDYANFFL-DRAKP--FPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVD 241
+ Y + ++ D+ L H +R ++CL+LS+ FQQ+SFVNSIAT KGG HVD
Sbjct: 277 RSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVD 336
Query: 242 YITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPA 298
Y+ Q+ + EV+KKK+ V+V VKN +WVF+N LI+NP F+SQTKE +T +P
Sbjct: 337 YVVDQVVGKLI-EVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPK 395
Query: 299 RLGLKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKL 338
G K I++++L + FK +T + DA
Sbjct: 396 SFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDAND 455
Query: 339 AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKK 397
AG S +CTLILT+G K LA+SGL V+ D YGVFPL K+LN S K + +
Sbjct: 456 AGGKHSLECTLILTEGDSAKSLAVSGLG-VIGRDRYGVFPLRGKILNVREASHKQIMENA 514
Query: 398 EIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLL 454
EI N++ I+GL K Y +A K LRYG++M+M +QD+DG+H KGLLINF + WPSLL
Sbjct: 515 EINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 574
Query: 455 KVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL 514
K F+ F PI+K S K +ELSF S+ ++++WKK + N W+IKY +GL
Sbjct: 575 KHG-FLEEFITPIVKAS-------KNKQELSFYSIPEFDEWKKHIENQ-KAWKIKYYKGL 625
Query: 515 --SSAQEVREYFQDLGKHRAYFVW-DDKDETSIKLAFSKKA-EEWEAWIGNSQP------ 564
S+A+E +EYF D+ +HR F + +D+ +I LAFSKK ++ + W+ N
Sbjct: 626 GTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR 685
Query: 565 ----------GTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCS 614
GT K + Y +F+NKEL+ S + +RSIPS+VDG GQRK LF
Sbjct: 686 LHGLPEQFLYGTAT---KHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTC 742
Query: 615 FEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTR 674
F+ N ++ +V +L V E S H+G+Q++ TI+ +AQ+FVGSNNINLL P GQFGTR
Sbjct: 743 FKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTR 802
Query: 675 DLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGC 734
GGKD AS R ++ L+ + RLLFP DD LL++L +D + ++P WYIPIIP+VL+NG
Sbjct: 803 LHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGA 862
Query: 735 HAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDG 794
+GT ++ +P Y EI+ NVRR L+ + M P YK F GTI++ G Y V G
Sbjct: 863 EGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQE--LGQNQYAVSG 920
Query: 795 LVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVN 848
+ ++ T I ELP+R WT+ YK+ + + G LI +++ V F V
Sbjct: 921 EIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVK 980
Query: 849 VKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYY 908
+ +E++A E L K F L T++ ++M LFD G +KKY T + IL+EF LRL YY
Sbjct: 981 MTEEKLAQAEA-AGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYY 1039
Query: 909 VRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL-KKGKSAEPHVAG 967
RK++LV L + +FI + K NR + LI++L ++G ++P A
Sbjct: 1040 GLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVRAW 1099
Query: 968 AIDYSSKEQEAGEQESVSQSVSIEGATLG-DYEYLSSLPFENFTLESLKKLEAELDEKEN 1026
+E Q S S G G D+ Y+ ++ + T E +++L + D K
Sbjct: 1100 KEAQEKAAEEEDTQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGR 1159
Query: 1027 ELKTLEHTSPDLMWLNDLELFEKEFD 1052
E+ L+ SP +W DL F +E D
Sbjct: 1160 EVNDLKRKSPSDLWKEDLAAFVEELD 1185
>TP2A_PIG (O46374) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3)
Length = 1533
Score = 612 bits (1578), Expect = e-174
Identities = 390/995 (39%), Positives = 568/995 (56%), Gaps = 94/995 (9%)
Query: 127 NGK-WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKS 183
NG+ +T + F PDL KF M++L+KD++ALM +R D+A G T V V LNG +PVK
Sbjct: 210 NGEDYTCITFHPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNKLPVKG 266
Query: 184 FKDYANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHV 240
F+ Y + +L D+ PL H ++ R E+CL++S+ FQQ+SFVNSIAT KGG HV
Sbjct: 267 FRSYVDLYLKDKVDETGNPLKIIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHV 326
Query: 241 DYITKQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTK- 296
DY+ QI + +V+KKK+ V V A VKN +W+FVNALI+NP F+SQTKE +T +
Sbjct: 327 DYVADQIVAKLV-DVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQV 385
Query: 297 -----PARLGLKFFPGSMLNDVQKSQILDNLLPRIPFKHRTHV----------------- 334
+L KF ++ I++++L + FK + +
Sbjct: 386 KSFGSTCQLSEKFIKAAI-----GCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPK 440
Query: 335 --DAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK 392
DA AG +S +CTLILT+G K LA+SGL VV D YGVFPL K+LN S K
Sbjct: 441 LDDANDAGGRNSTECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKILNVREASHK 499
Query: 393 -LFKKKEIQNLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYS 448
+ + EI N++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF +
Sbjct: 500 QIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHH 559
Query: 449 FWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEI 508
WPSLL+ +F+ F PI+KVS K +E++F S+ ++E+WK N W++
Sbjct: 560 NWPSLLR-HRFLEEFITPIVKVS-------KNKQEMAFYSLPEFEEWKSSTPNHKK-WKV 610
Query: 509 KYCQGL--SSAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKKA----EEW------ 555
KY +GL S+++E +EYF D+ +HR F + +D+ +I LAFSKK +EW
Sbjct: 611 KYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTHFME 670
Query: 556 ----EAWIGNSQPGTCNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTL 611
+G + + Y +F+NKEL+ S + +RSIPS+VDGL GQRK L
Sbjct: 671 DRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVL 730
Query: 612 FCSFEMNLTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQF 671
F F+ N ++ +V +L V E S H+G+ S+ TII +AQ+FVGSNN+NLL P GQF
Sbjct: 731 FTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQF 790
Query: 672 GTRDLGGKDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLV 731
GTR GGKD AS R ++ L+ + RLLFP DD L++L +D + ++P WYIPIIP+VL+
Sbjct: 791 GTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLI 850
Query: 732 NGCHAMGTCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYT 791
NG +GT +S IP + E++ N+R ++ EE + M P YK F GTIE+ A Y
Sbjct: 851 NGAEGIGTGWSCKIPNFDVREVVNNIRLLMDGEEPLPMLPSYKNFKGTIEELAP--NQYV 908
Query: 792 VDGLVERINEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNF 845
+ G V +N T I ELPIR WT+ YK+ + + G LI +R+ V F
Sbjct: 909 ISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKF 968
Query: 846 KVNVKQEEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRL 905
V + +E++A E+ L K F L +++ ++M LFD G +KKY+T IL +F LRL
Sbjct: 969 VVKMTEEKLAEAER-VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRL 1027
Query: 906 KYYVRRKQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPH 964
KYY RK++L+ L + +FI ++ K N+ + EL+ ++++G ++P
Sbjct: 1028 KYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPV 1087
Query: 965 VA------GAIDYSSKEQEAGEQES-VSQSVSIEGATLGDYEYLSSLPFENFTLESLKKL 1017
A D E+ E+E+ S SV+ G T + YL +P T E +L
Sbjct: 1088 KAWKEAQQKVPDEEENEESDNEKEADKSDSVADSGPT---FNYLLDMPLWYLTKEKKDEL 1144
Query: 1018 EAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
+EKE EL+TL+ SP +W DL F +E +
Sbjct: 1145 CKLRNEKEQELETLKRKSPSDLWKEDLAAFIEELE 1179
>TP2A_MOUSE (Q01320) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3)
Length = 1528
Score = 610 bits (1572), Expect = e-174
Identities = 381/984 (38%), Positives = 563/984 (56%), Gaps = 79/984 (8%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGET--VTVVLNGTVIPVKSFKDY 187
+T + F+PDL KF M++L+KD++ALM +R D+A G T V V LNG ++PVK F+ Y
Sbjct: 213 YTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIA---GSTKDVKVFLNGNMLPVKGFRSY 269
Query: 188 ANFFL-DRAKPF--PLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYIT 244
+ +L D+ L H ++ R E+CL++S+ FQQ+SFVNSIAT KGG HVDY+
Sbjct: 270 VDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVA 329
Query: 245 KQITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLG 301
QI + + +V+KKK+ V V A VKN +W+FVNALI+NP F+SQTKE +T + G
Sbjct: 330 DQIVSKLV-DVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFG 388
Query: 302 LKF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV-------------------DAKLAGR 341
+ I++++L + FK + + DA AG
Sbjct: 389 STCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGS 448
Query: 342 PDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQ 400
+S +CTLILT+G K LA+SGL VV D YGVFPL K+LN S K + + EI
Sbjct: 449 RNSTECTLILTEGDSAKTLAVSGLG-VVGRDKYGVFPLRGKILNVREASHKQIMENAEIN 507
Query: 401 NLMAILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVS 457
N++ I+GL K Y + K LRYG++M+M +QD+DG+H KGLLINF + WPSLL+
Sbjct: 508 NIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-H 566
Query: 458 KFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--S 515
+F+ F PI+KVS K +E++F S+ ++E+WK N W++KY +GL S
Sbjct: 567 RFLEEFITPIVKVS-------KNKQEIAFYSLPEFEEWKSSTPNHKK-WKVKYYKGLGTS 618
Query: 516 SAQEVREYFQDLGKHRAYFVWDD-KDETSIKLAFSKK-AEEWEAWIGNSQPGTCNYERKV 573
+++E +EYF D+ +HR F + +D+ +I LAFSKK ++ + W+ N +RK+
Sbjct: 619 TSKEAKEYFADMKRHRIQFKYPGPEDDAAISLAFSKKQVDDRKEWLTNFMED--RRQRKL 676
Query: 574 IN---------------YRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMN 618
+ Y +F+NKEL+ S + +RSIPS+VDGL GQRK LF F+ N
Sbjct: 677 LGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRN 736
Query: 619 LTKQTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGG 678
++ +V +L V E S H+G+ S+ TII +AQ+FVGSNN+NLL P GQFGTR GG
Sbjct: 737 DKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGG 796
Query: 679 KDHASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMG 738
KD AS R ++ L+ + RLLFP DD L +L +D + ++P WY PI +VL+NG +G
Sbjct: 797 KDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYNPINTMVLINGAEGIG 856
Query: 739 TCFSSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVER 798
T +S IP + E++ N+RR L+ EE + M P YK F GTIE+ A Y ++G V
Sbjct: 857 TGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELAS--NQYVINGEVAI 914
Query: 799 INEQTFRIKELPIRMWTEDYKKFLEKITARG------LIESFRQKGDYEIVNFKVNVKQE 852
++ T I ELPIR WT+ YK+ + + G LI +R+ V F + + +E
Sbjct: 915 LDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEE 974
Query: 853 EIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRK 912
++A E+ L K F L +++ ++M LFD G +KKY+T IL +F LRLKYY RK
Sbjct: 975 KLAEAER-VGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRK 1033
Query: 913 QYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEPHVA-GAID 970
++L+ L + +FI ++ K N+ + EL+ ++++G ++P A
Sbjct: 1034 EWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQ 1093
Query: 971 YSSKEQEAGEQESVSQSVSIEGATLG-DYEYLSSLPFENFTLESLKKLEAELDEKENELK 1029
++E E+ S S A G + YL +P T E +L + +EKE EL
Sbjct: 1094 QKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELN 1153
Query: 1030 TLEHTSPDLMWLNDLELFEKEFDV 1053
TL+ SP +W DL +F +E +V
Sbjct: 1154 TLKQKSPSDLWKEDLAVFIEELEV 1177
>TOP2_DROME (P15348) DNA topoisomerase II (EC 5.99.1.3)
Length = 1447
Score = 604 bits (1558), Expect = e-172
Identities = 378/998 (37%), Positives = 568/998 (56%), Gaps = 90/998 (9%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
+T + F PDL KF M L++D++ALM +R D+A + V+V LNG + V++FKDY +
Sbjct: 195 YTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAAS-SKGVSVFLNGNKLGVRNFKDYID 253
Query: 190 FFL----DRAKPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITK 245
+ D + P P+ H +R E+ SD FQQVSFVNSIAT KGG HVD++
Sbjct: 254 LHIKNTDDDSGP-PIKIVHEVANERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVD 312
Query: 246 QITTYIKKEVLKKKH---VNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGL 302
+ + EVLKKK+ +N+ V+N LWVFVN LI+NP F+SQTKE +T + G
Sbjct: 313 NLIKQLL-EVLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGS 371
Query: 303 KF-FPGSMLNDVQKSQILDNLLPRIPFKHRTHV------------------DAKLAGRPD 343
K +N++ KS I++++L FK + + DA AG +
Sbjct: 372 KCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKN 431
Query: 344 SGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDS-RKLFKKKEIQNL 402
S KCTLILT+G K LA+SGL V+ DLYGVFPL KLLN + ++L + EI NL
Sbjct: 432 SIKCTLILTEGDSAKSLAVSGLG-VIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNL 490
Query: 403 MAILGLVRNKKY---SNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKF 459
I+GL KKY + K LRYG++M+M +QD+DG+H KGLLINF ++ WP LL++ F
Sbjct: 491 CKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-F 549
Query: 460 MSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSA 517
+ F PI+K + KK +ELSF S+ ++E+WK + N + + IKY +GL S++
Sbjct: 550 LEEFITPIVKAT-------KKNEELSFYSLPEFEEWKNDTANH-HTYNIKYYKGLGTSTS 601
Query: 518 QEVREYFQDLGKHRAYFVWDDK-DETSIKLAFSKK-AEEWEAWIGNSQ-----------P 564
+E +EYFQD+ +HR F +D D+ SI +AFSKK E + W+ N P
Sbjct: 602 KEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMDEVKRRKELGLP 661
Query: 565 GTCNYER--KVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQ 622
Y + K I Y +F+N EL+ S + +RSIPS+VDGL GQRK +F F+ N ++
Sbjct: 662 ERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKRE 721
Query: 623 TEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHA 682
+V +L+ V E S H+G+ S+ TI+ +AQ+FVG+NNINLL P GQFGTR GGKD A
Sbjct: 722 VKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCA 781
Query: 683 SSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFS 742
S+R ++ ++ +TRL++ DD LL+Y +DG+ I+P WY+PIIP+VLVNG +GT +S
Sbjct: 782 SARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWS 841
Query: 743 SDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQ 802
+ I Y+P EI+KN+R+ +N +E M PWYK F G +E + G Y G ++ ++
Sbjct: 842 TKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSD--GRYIQTGNIQILSGN 899
Query: 803 TFRIKELPIRMWTEDYKK-FLEKIT-----ARGLIESFRQKGDYEIVNFKVNVKQEEIAT 856
I ELP+ +WT++YK+ LE ++ +G+I +R+ V F ++ E
Sbjct: 900 RLEISELPVGVWTQNYKENVLEPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFER 959
Query: 857 IEKDE-ELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYL 915
I +E + F LT T+ST+ M+ FD ++++ T IL+E+ LR +YY RR+ +L
Sbjct: 960 IHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFL 1019
Query: 916 VKNFTQLLRSLRIKQKFISNIVNEKFNPINR-RAELLIEILKKGKSAEP-----HVAGAI 969
V T L + +FI +K N+ R + E+LK+G +P
Sbjct: 1020 VGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKME 1079
Query: 970 DYSSKEQEAGEQESVSQSVSIEG---------------ATLGDYEYLSSLPFENFTLESL 1014
D ++E E+E + SVS + + ++YL + T E
Sbjct: 1080 DAEQADEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKK 1139
Query: 1015 KKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
+L + D K +EL++L +P+++WL+DL+ E + +
Sbjct: 1140 NELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKLN 1177
>TOP2_CAEEL (Q23670) Probable DNA topoisomerase II (EC 5.99.1.3)
Length = 1520
Score = 604 bits (1558), Expect = e-172
Identities = 381/998 (38%), Positives = 565/998 (56%), Gaps = 94/998 (9%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
+T + F PDL KF MK L+ D+ LM +R D+A + V V LNG IP+K F+DY
Sbjct: 249 FTKITFSPDLAKFKMKELDDDICHLMARRAYDVAGS-SKGVAVFLNGKRIPIKGFEDYVQ 307
Query: 190 FFLDRA--KPFPLPRTHAKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVDYITKQ- 246
+ + + PL + ++GDR ++ L+LS+ FQQVSFVNSIAT KGG HVDY+ Q
Sbjct: 308 MYTSQFNNEGEPLKIAYEQVGDRWQVALALSEKGFQQVSFVNSIATTKGGRHVDYVADQM 367
Query: 247 ITTYIK--KEVLKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTTKPARLGLKF 304
+ +I K L K +N+ +KN +WVFVN LI+NP F+SQTKE +T + + G
Sbjct: 368 VAKFIDSIKRKLTKTSMNIKPFQIKNHMWVFVNCLIENPTFDSQTKETMTLQQKQFGSTC 427
Query: 305 FPGSMLNDVQKSQ-ILDNLLPRIPFKHRTHV-------------------DAKLAGRPDS 344
+ S I D ++ + FK + DA AG +S
Sbjct: 428 VLSEKFSKAASSVGITDAVMSWVRFKQMDDLNKKCSKTKTSKLKGIPKLEDANDAGTKNS 487
Query: 345 GKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSRK-LFKKKEIQNLM 403
+CTLILT+G K LA+SGLS VV D YGVFPL KLLN + K + E+ ++
Sbjct: 488 QQCTLILTEGDSAKTLAVSGLS-VVGRDKYGVFPLRGKLLNVREGNMKQIADNAEVNAMI 546
Query: 404 AILGLVRNKKYSNA---KCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKVSKFM 460
ILGL KKY K LRYG+LMVMA+QD+DG+H KGL+INF + FWPSL++ F+
Sbjct: 547 KILGLQYKKKYETEDDFKTLRYGKLMVMADQDQDGSHIKGLVINFIHHFWPSLIQ-RNFV 605
Query: 461 SVFTFPIIKVSMYNASDSKKGKE-LSFDSMQQYEDWKKELGNTANDWEIKYCQGL--SSA 517
F PI+K + KGKE +SF S+ +Y +W+ N + ++IKY +GL S++
Sbjct: 606 EEFITPIVKAT--------KGKEEVSFYSLPEYSEWRMNTDNWKS-YKIKYYKGLGTSTS 656
Query: 518 QEVREYFQDLGKHRAYFVWDDKDE-TSIKLAFSKKA-EEWEAWI-------------GNS 562
+E +EYF D+ +HR F ++ D+ ++ +AFSKK EE + W+ G +
Sbjct: 657 KEAKEYFLDMVRHRIRFKYNGADDDNAVDMAFSKKKIEERKDWLSKWMREKKDRKQQGLA 716
Query: 563 QPGTCNYERKVINYRNFVNKEL-LFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTK 621
+ N + + + +++FVN+EL LFS++ N +RSIP +VDG GQRK LF F+ +
Sbjct: 717 EEYLYNKDTRFVTFKDFVNRELVLFSNLDN-ERSIPCLVDGFKPGQRKVLFACFKRADKR 775
Query: 622 QTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDH 681
+ +V +L V E S H+G+QS+ TI+ +AQD+VGSNNINLL+P GQFGTR GGKD
Sbjct: 776 EVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDS 835
Query: 682 ASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCF 741
AS+R ++ +L+ VTR LFP DD +L +L E+ + I+P WY PIIP+VLVNG +GT +
Sbjct: 836 ASARYIFTQLSPVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGIGTGW 895
Query: 742 SSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINE 801
S++IP Y+P E++KN++R + E ++ PWYK F G I + + G V +++
Sbjct: 896 STNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDP--SRFACYGEVAVLDD 953
Query: 802 QTFRIKELPIRMWTEDYKKFLEKITARGLIESFRQKG----DYE------IVNFKVNVKQ 851
T I ELPI+ WT+DYK EK+ GL+ES +K DY+ V F V +
Sbjct: 954 NTIEITELPIKQWTQDYK---EKV-LEGLMESSDKKSPVIVDYKEYHTDTTVKFVVKLSP 1009
Query: 852 EEIATIEKDEELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRR 911
++ +E+ ++L + F L I+T+ M LFDA G ++ Y +PE I +EF R + YV+R
Sbjct: 1010 GKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGCLRTYTSPEAITQEFYDSRQEKYVQR 1069
Query: 912 KQYLVKNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEILKKGK-SAEPHVAGAID 970
K+YL+ + L + +FI +N + N++ ++++L K K A+P +
Sbjct: 1070 KEYLLGVLQAQSKRLTNQARFILAKINNEIVLENKKKAAIVDVLIKMKFDADPVKKWKEE 1129
Query: 971 YSSKE-QEAG---------------EQESVSQSVSIEGATLGDYEYLSSLPFENFTLESL 1014
KE +E+G E E++S + L DY+YL + + E
Sbjct: 1130 QKLKELRESGEIELDEDDLAAVAVEEDEAISSAAKAVETKLSDYDYLVGMALIKLSEEEK 1189
Query: 1015 KKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
KL E +EK E++ +E + +W DL+ F E D
Sbjct: 1190 NKLIKESEEKMAEVRVIEKKTWQDLWHEDLDNFVSELD 1227
>TOP2_PENCH (Q9Y8G8) DNA topoisomerase II (EC 5.99.1.3)
Length = 1587
Score = 595 bits (1535), Expect = e-169
Identities = 374/965 (38%), Positives = 554/965 (56%), Gaps = 59/965 (6%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
+T V FKPD KF M ++ D AL+K+RV D+A V V LNG+ IP+++FK Y
Sbjct: 249 YTKVTFKPDYAKFGMTGMDDDFEALVKRRVYDLAGTA--KVAVKLNGSRIPIRNFKMYME 306
Query: 190 FFL-----DRAKPFPLPRTH---AKLGDRLEICLSLSDGKFQQVSFVNSIATIKGGTHVD 241
+ +R P + R E+ ++SDG FQQVSFVNSIA GGTHV+
Sbjct: 307 MYTKAIRRERGDMGPAGKNEIITCSPDPRWEVGFAVSDGAFQQVSFVNSIAITSGGTHVN 366
Query: 242 YITKQITTYIKKEVLKKKHVNVNADTVK-----NQLWVFVNALIDNPAFNSQTKEMLTTK 296
YI QI + + ++V KK N N T+K N +++FVNALI NPAF SQTKE LTTK
Sbjct: 367 YIADQICSKLAEQVKKK---NKNGATLKPAQIRNHIFIFVNALIVNPAFTSQTKEQLTTK 423
Query: 297 PARLGLK------FFPGSMLNDVQKS------QILDNLLPRIPFKHRTHV------DAKL 338
++ G K F+ + +V + Q D +L + R+ + DA
Sbjct: 424 QSQFGSKCVLEEDFYKKILKTEVMTNILHFAQQKADQMLKKTDGGRRSRMNNPKLTDANK 483
Query: 339 AGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRDSR--KLFKK 396
AG + CTLILT+G K LAM+G AVV PDL+GVFPL KLLN RD+ ++ K
Sbjct: 484 AGTKEGHHCTLILTEGDSAKGLAMAG-RAVVGPDLFGVFPLRGKLLNV-RDASFDQIAKN 541
Query: 397 KEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSLLKV 456
+EIQN+ +GL K+Y++ + LRYG LM+ +QD DG+H KGLLINF + +PSLLK+
Sbjct: 542 QEIQNIKNFIGLQHKKEYTDTRGLRYGHLMITTDQDHDGSHIKGLLINFLQAQFPSLLKI 601
Query: 457 SKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQGL-- 514
+F+ F PI+KV + K+ SF +M +YE WK+E G+ WE KY +GL
Sbjct: 602 PEFLIEFITPIVKV--WKGDPKNPTKQRSFFTMPEYEAWKEEHGHERG-WEHKYYKGLGT 658
Query: 515 SSAQEVREYFQDLGKH-RAYFVWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGT-CNYER 571
S+ ++ + YF+DL +H + + D + I+LAFSKK A+E + + +PGT ++
Sbjct: 659 STTEDAQIYFRDLDRHLKEFHTMQDNEVELIELAFSKKKADERKGNVRQFRPGTFLDHSV 718
Query: 572 KVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVCRLTAY 631
I Y +F+NKEL+ SM + RSIPSVVDGL GQRK L+ F NL K +V L +
Sbjct: 719 DKITYTDFINKELILFSMADNIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGH 778
Query: 632 VTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRKLYIKL 691
V+ + +G+ S+ TI+G+AQ FVGSNN+N L P G FG+R GG D AS+R +Y +L
Sbjct: 779 VSGTTAYQHGEGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRL 838
Query: 692 NCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIPKYHPY 751
R +F DD LL Y +DG I+ Y+P++P++L+NG +GT +SS P Y+P
Sbjct: 839 WPFARRVFHNHDDPLLTYNEDDGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPE 898
Query: 752 EIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRIKELPI 811
+I++N++R ++ E + M+PW++GF G E +A G + G+++ ++ I ELPI
Sbjct: 899 DIVENLKRMMDGEPLKPMQPWFRGFTG--EVTAVGQDRFKFSGIIKETGDKEVEITELPI 956
Query: 812 RMWTEDYKKFLEKI----TARGLIESFRQKGDYEIVNFKVNVKQEEIATIEKDEELRKKF 867
R WT+D+K LE I I+ ++ + V+F + + ++ + T E L +KF
Sbjct: 957 RTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIA-EGLEEKF 1015
Query: 868 NLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFTQLLRSLR 927
L+ T++T+N+ FD E +I KY + E I++EF +RLKYY RRKQY + + L L
Sbjct: 1016 KLSKTMTTTNLVAFDPE-RITKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKELDKLS 1074
Query: 928 IKQKFISNIVNEKF-NPINRRAELLIEILKKGKSAEPHVAGAIDYSSKEQEAGEQESVSQ 986
+ +F+ I++ K ++A L+ E+ +K P V A+ E E+E S+
Sbjct: 1075 NQARFVQMIIDGKLVISKKKKAVLVAELKEKDFKPFPKVKEAVKAGETEPVVEEEED-SE 1133
Query: 987 SVSIEGATLGDYEYLSSLPFENFTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLEL 1046
S E Y+YL +P + T E ++KL ++ +KE E+ TL S + +W DLE
Sbjct: 1134 SGDTE-VLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWKRDLED 1192
Query: 1047 FEKEF 1051
F E+
Sbjct: 1193 FINEW 1197
>TOP2_CANGA (O93794) DNA topoisomerase II (EC 5.99.1.3)
Length = 1406
Score = 592 bits (1527), Expect = e-168
Identities = 366/988 (37%), Positives = 549/988 (55%), Gaps = 88/988 (8%)
Query: 130 WTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYAN 189
+T V FKPDL +F M++L+ D++ +M++RV D+ + + V V LNG + +++FK+Y
Sbjct: 193 YTKVAFKPDLSRFGMESLDSDILGVMRRRVYDINGSVRD-VNVYLNGKPLKIRNFKNYVE 251
Query: 190 FFLDRAK-------------PFPLPRT-HAKLGDRLEICLSLSDGKFQQVSFVNSIATIK 235
+L + P +P + ++ DR EI ++SD F+QVSFVNSIAT
Sbjct: 252 LYLKSLEKMRKMDNGESDTTPSNIPTILYERVSDRWEIAFAVSDISFKQVSFVNSIATTT 311
Query: 236 GGTHVDYITKQITTYIKKEVLKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTKEMLTT 295
GGTHV+YI QI + ++LKKK N+ +KN +++F+N LI+NPAF SQTKE LTT
Sbjct: 312 GGTHVNYIADQIVRKVS-DILKKKKKNIKPYQIKNNMFIFINCLIENPAFTSQTKEQLTT 370
Query: 296 KPARLGLKF-FPGSMLNDVQKSQIL-----------DNLLPRIPFKHRTHV-------DA 336
+ G + +N + K+ + +N L + ++ + DA
Sbjct: 371 RVKDFGSRCDISSDYINKIMKTDLATKIFEIADENANNALKKSDGSRKSRITDYPKLEDA 430
Query: 337 KLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLN---ATRDSRKL 393
AG D KCTLILT+G LA++GL AVV D YG +PL K+LN AT D ++
Sbjct: 431 NKAGTKDGYKCTLILTEGDSALSLAVAGL-AVVGRDYYGCYPLRGKMLNVREATAD--QI 487
Query: 394 FKKKEIQNLMAILGLVRNKKYSNAKCLRYGQLMVMANQDEDGAHFKGLLINFFYSFWPSL 453
K EIQ + I+GL KKY + K LRYG LM+M +QD DG+H KGL+INF + +P L
Sbjct: 488 LKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFIETSFPGL 547
Query: 454 LKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDWEIKYCQG 513
L + F+ F PI+KV++ K +SF ++ YE W++E + + W+ KY +G
Sbjct: 548 LDIPGFLIEFITPIVKVTITKPIK----KVISFFNLPDYEKWREEESHKYS-WKQKYYKG 602
Query: 514 L--SSAQEVREYFQDLGKHRAYF---VWDDKDETSIKLAFSKK-AEEWEAWIGNSQPGTC 567
L S++ E+ EYF +L H F DDKD I LAFSKK A++ + W+ +PGT
Sbjct: 603 LGTSTSPEIIEYFSNLDTHLKKFHALQGDDKD--LIDLAFSKKKADDRKEWLRQYEPGTV 660
Query: 568 -NYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTKQTEVC 626
+ I +F+NKEL+ S+ + RSIPSV+DG GQRK L+ F+ NLT + +V
Sbjct: 661 LDPTLNEIPISDFINKELILFSLADNVRSIPSVLDGFKPGQRKVLYTCFKKNLTTEKKVA 720
Query: 627 RLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDHASSRK 686
L V++++ H+G+Q++ TIIGMAQ+FVG+NNI L P G FGTR GGKD A++R
Sbjct: 721 NLAPAVSDYTAYHHGEQALVQTIIGMAQNFVGTNNIYFLKPNGAFGTRATGGKDAAAARY 780
Query: 687 LYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCFSSDIP 746
+Y +LN + R +F DD L Y+ ED ++++P WY+P++P+VL+NG +GT +S+ IP
Sbjct: 781 IYTELNKIARKVFHPADDPLFRYVQEDEKTVEPEWYLPVVPMVLINGAEGIGTGWSTSIP 840
Query: 747 KYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINEQTFRI 806
++P +++ N+R LN+EEM M PW++G+ GT+EK Y + G +E++ T I
Sbjct: 841 PFNPLDVVNNIRHLLNDEEMDDMHPWFRGWTGTMEKIES--QRYRMYGRIEQVGPNTLEI 898
Query: 807 KELPIRMWTEDYKKFLEKITARGLIESFR------QKGDYEIVNFKVNVKQEEIATIEKD 860
ELP R WT K+ L + G E + ++ E + F + + EE+ K
Sbjct: 899 TELPARTWTSTIKEHL--LLGLGGSEKVKPWIKDMEEQHAETIKFIIKLTDEEMTKTRK- 955
Query: 861 EELRKKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLVKNFT 920
++F L IS NM FD GKIKKY+ +IL++F +RL+YY +RK Y+
Sbjct: 956 LGFYERFKLISPISLQNMVAFDYRGKIKKYDHVHEILKDFYEVRLEYYQKRKDYMTGRLQ 1015
Query: 921 QLLRSLRIKQKFISNIVNEKFNPINRRAELLIEILKK------GKSAEPHVAGAIDYS-- 972
L + KFI I+++ N+ + LI L++ K +PH G ID
Sbjct: 1016 WEAEKLSFQVKFIKMIIDKSLIVTNKPKKQLISELEELGFPRINKEGKPHF-GKIDEEVE 1074
Query: 973 -----------SKEQEAGEQESVSQSVSIEG--ATLGDYEYLSSLPFENFTLESLKKLEA 1019
+ +EA ++ ++ G G YEYL L + T E +KL
Sbjct: 1075 AIISEDEDEDLEESEEATRKKDKDDESTVNGPEELFGTYEYLLGLKIWSLTKERYEKLLK 1134
Query: 1020 ELDEKENELKTLEHTSPDLMWLNDLELF 1047
+ EKE EL+ L S +W NDL+ F
Sbjct: 1135 QKQEKETELENLLKLSAKDLWNNDLDDF 1162
>TOP2_CANAL (P87078) DNA topoisomerase II (EC 5.99.1.3)
Length = 1461
Score = 590 bits (1522), Expect = e-168
Identities = 361/1004 (35%), Positives = 560/1004 (54%), Gaps = 92/1004 (9%)
Query: 129 KWTNVMFKPDLDKFDMKNLEKDVIALMKKRVLDMAVCLGETVTVVLNGTVIPVKSFKDYA 188
++T + F+PDL KFDM L+ D+++++++RV D+ + + + LN + + SFK Y
Sbjct: 243 EYTKITFRPDLSKFDMDCLDNDLLSVLRRRVYDLCGTV-KNCNIYLNDKRLNISSFKGYV 301
Query: 189 NFFLDRAK---PFPLPR----------THAKLGDRLEICLSLSDGKFQQVSFVNSIATIK 235
++ K P P P+ H DR E+ ++SDG F QVSFVNSIAT
Sbjct: 302 EMYVKAIKERSPEPEPQDGTIKNFTTIVHEVFNDRWEVAFAVSDGSFNQVSFVNSIATTS 361
Query: 236 GGTHVDYITKQIT-----TYIKKEVLKKKHVNVNADTVKNQLWVFVNALIDNPAFNSQTK 290
GGTHV Y++ QI T KKE KKK + + V++ +++F+N LI+NPAF SQTK
Sbjct: 362 GGTHVKYVSDQIINKLVETLSKKEKGKKK-LMIKPQEVRDNMFLFINCLIENPAFTSQTK 420
Query: 291 EMLTTKPARLGLK---FFPGSMLNDVQKSQILDNL-----------LPRIPFKHRTH--- 333
E LTTK ++ G K +++N + K+ I+D + L + ++
Sbjct: 421 EQLTTKVSQFGGKDKFVANDNLINRILKTSIVDKIRAIANANEDKALQKADGSRKSRIKG 480
Query: 334 ----VDAKLAGRPDSGKCTLILTQGQYVKDLAMSGLSAVVDPDLYGVFPLSSKLLNATRD 389
VDA AG D CTLILT+G +LA++GLS VV D YG FPL KLLN
Sbjct: 481 QVNLVDANKAGTKDGHNCTLILTEGLSAMNLAVAGLS-VVGRDYYGCFPLRGKLLNVREA 539
Query: 390 SR-KLFKKKEIQNLMAILGLVRNKKYS--NAKCLRYGQLMVMANQDEDGAHFKGLLINFF 446
S ++ K EI +L I+GL K Y+ N K LRYG +M+M +QD+DG+H KGL+INF
Sbjct: 540 SADQISKNAEINSLKQIIGLQHKKVYTAENIKSLRYGHIMIMTDQDQDGSHIKGLIINFL 599
Query: 447 YSFWPSLLKVSKFMSVFTFPIIKVSMYNASDSKKGKELSFDSMQQYEDWKKELGNTANDW 506
+ +P LL + F+ F PI+KV++ A + + + F +M ++E W+ G W
Sbjct: 600 ETSFPGLLDIPGFLLEFITPIVKVTV-KARGAGGKRVIPFYTMPEFEHWRDTEGKQCR-W 657
Query: 507 EIKYCQGL--SSAQEVREYFQDLGKH-RAYFVWDDKDETSIKLAFSKK-AEEWEAWIGNS 562
KY +GL S+ E REYF L +H + + +D+ I LAFSKK A+E + W+
Sbjct: 658 TQKYYKGLGTSTPMEAREYFTALDRHLKRFHALQGEDKDYIDLAFSKKKADERKEWLQGF 717
Query: 563 QPGT-CNYERKVINYRNFVNKELLFSSMKNLQRSIPSVVDGLTLGQRKTLFCSFEMNLTK 621
PGT + E I +F+NKE + SM + RSIPSV+DG GQRK L+ F+ L
Sbjct: 718 LPGTHLDPEITEIPISDFINKEFILFSMSDNVRSIPSVLDGFKPGQRKVLYGCFKKKLRS 777
Query: 622 QTEVCRLTAYVTEHSYCHYGQQSIASTIIGMAQDFVGSNNINLLIPYGQFGTRDLGGKDH 681
+ +V +L YV+E++ H+G+QS+ TIIG+AQ+FVGSNNIN+L P G FG+R GGKD
Sbjct: 778 EIKVAQLAGYVSENTGYHHGEQSLVQTIIGLAQNFVGSNNINVLKPNGSFGSRAAGGKDF 837
Query: 682 ASSRKLYIKLNCVTRLLFPVDDDKLLEYLNEDGRSIQPNWYIPIIPLVLVNGCHAMGTCF 741
+++R ++ +L+ +TR +F DD L Y+ +D ++++P WY+P++P++LVNG +GT +
Sbjct: 838 SAARYIFTELSEITRKIFNPLDDPLYTYVQDDEQTVEPEWYLPVLPMILVNGAEGIGTGW 897
Query: 742 SSDIPKYHPYEIIKNVRRFLNNEEMVSMKPWYKGFGGTIEKSAKGIGYYTVDGLVERINE 801
S++IP Y+P +++ N+RR +N EE+ M PWYKG+GG +E G + V G +E+I+
Sbjct: 898 STNIPSYNPKDLVTNIRRLMNGEELQEMTPWYKGWGGDLE--PMGPQKFKVSGRIEQIDS 955
Query: 802 QTFRIKELPIRMWTEDYKKFLEKITARGLIESF-RQKGDYEIVNFKVNVKQEEIATIEKD 860
T I E+P++ WT + K+FL + + + ++ + + VK + E
Sbjct: 956 NTVEITEIPVKTWTNNVKEFLLSGFGNEKTQPWIKDMEEHHTTSIRFVVK---LTDAEMQ 1012
Query: 861 EELR----KKFNLTCTISTSNMYLFDAEGKIKKYNTPEQILEEFCTLRLKYYVRRKQYLV 916
+ LR ++F L ++S +NM FD G+IKKYN +I+++F +RL+YY +RK Y+
Sbjct: 1013 KSLRIGLLERFKLVSSLSLANMVAFDPMGRIKKYNDVLEIIKDFYYVRLEYYQKRKDYMT 1072
Query: 917 KNFTQLLRSLRIKQKFISNIVNEKFNPINRRAELLIEIL------------KKGKSAEPH 964
N L L + +FI I+ ++ + N++ + L+ +L K KS+E
Sbjct: 1073 DNLQNQLLMLSEQARFIKMIIEKQLSVANKKKKQLVALLEEHNFTKFSKDGKPIKSSEEL 1132
Query: 965 VAGAIDYSSKEQEAGEQE----------------SVSQSVSIEGATLGDYEYLSSLPFEN 1008
+ G D + +E+E EQE Q+ + Y+YL + +
Sbjct: 1133 LTG--DDADEEEETQEQEGDEDVGNTSVANIQEGEPEQAAHVPETIYSSYDYLLGMAIWS 1190
Query: 1009 FTLESLKKLEAELDEKENELKTLEHTSPDLMWLNDLELFEKEFD 1052
T E ++ + D+KE EL L S +W DL+ F EFD
Sbjct: 1191 LTYERFMRIMQQRDQKEAELNALLSKSAKDLWNQDLDEFLAEFD 1234
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.323 0.139 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,870,126
Number of Sequences: 164201
Number of extensions: 5106123
Number of successful extensions: 14753
Number of sequences better than 10.0: 225
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 14005
Number of HSP's gapped (non-prelim): 345
length of query: 1053
length of database: 59,974,054
effective HSP length: 121
effective length of query: 932
effective length of database: 40,105,733
effective search space: 37378543156
effective search space used: 37378543156
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 71 (32.0 bits)
Medicago: description of AC145202.5