BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144728.6 + phase: 0
(1266 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote... 956 0.0
MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote... 939 0.0
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote... 937 0.0
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote... 932 0.0
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote... 929 0.0
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein... 926 0.0
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote... 921 0.0
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote... 909 0.0
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote... 900 0.0
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1) 887 0.0
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,... 882 0.0
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s... 877 0.0
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,... 870 0.0
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote... 843 0.0
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,... 843 0.0
PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1 778 0.0
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g... 770 0.0
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g... 754 0.0
MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprote... 735 0.0
MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprote... 667 0.0
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein 1)
(CD243 antigen)
Length = 1280
Score = 956 bits (2470), Expect = 0.0
Identities = 528/1255 (42%), Positives = 773/1255 (61%), Gaps = 39/1255 (3%)
Query: 32 EKDITKEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFG-- 89
EKD KEK+ TV +F +++ D L M+VGT+ AI +G GLP+M ++ G+M F
Sbjct: 24 EKD-KKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANA 82
Query: 90 -------SNQTNTEDIVDQVTKVSLK-------YVYLAVGSGV--AAFLQVSCWMVTGER 133
SN TN DI D ++L+ Y Y +G+GV AA++QVS W + R
Sbjct: 83 GNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGR 142
Query: 134 QAARIRGLYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFV 193
Q +IR + I+RQ++ +FD + GE+ R++ D I + +G+K+G F Q +ATF
Sbjct: 143 QIHKIRKQFFHAIMRQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFF 201
Query: 194 GGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSI 253
GF++ FTRGW LT+V+++ P+L +S A A I+ K AYAKA V E+ + +I
Sbjct: 202 TGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAI 261
Query: 254 RTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMV 313
RTV +F G+K+ + Y+K+L + + G+ + + + +G L++ YALA W+G +V
Sbjct: 262 RTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLV 321
Query: 314 MEKGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPN 373
+ Y+ G V+ V VL + S+GQAS + AFA R AAY++F+ I +P ID+Y +
Sbjct: 322 LSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKS 381
Query: 374 GKILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVE 433
G ++I+G +E + V+FSYP+R E I G +L + SG T ALVG SG GKST + L++
Sbjct: 382 GHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQ 441
Query: 434 RFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIR 493
R YDP G V +DG +++ VR++R IG+VSQEPVLFA++I +NI YG++ T++EI
Sbjct: 442 RLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIE 501
Query: 494 SASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSAL 553
A + ANA FI KLP DT+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSAL
Sbjct: 502 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 561
Query: 554 DAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEG 613
D +SE VVQ LD+ RTT+V+AHRLSTVRNAD+IA G +V KG H EL+K+ +G
Sbjct: 562 DTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKE-KG 620
Query: 614 AYSQLVRLQEINKESE-ETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSF 672
Y +LV +Q E E E K E+ A R SL R S S+ S
Sbjct: 621 IYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDR 680
Query: 673 SVSSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFP 732
+S+ A+D E++P V R+ LN E P + G F AI NG + P
Sbjct: 681 KLSTK-----EALD---ESIP------PVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQP 726
Query: 733 IFGILTSSMIKTF--YEPFDEMKKDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQ 790
F I+ S +I F + + +++S ++++F+ LG S + Q + F AG L +
Sbjct: 727 AFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTK 786
Query: 791 RIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSG 850
R+R + F ++ +V WFD+P+N++G++ RL+ DAA V+ +G L ++ N+A +G
Sbjct: 787 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 846
Query: 851 LIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRI 910
+II+F+ WQL L++L ++P+I + G V+MK + G + K E A ++A +A+ + R
Sbjct: 847 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 906
Query: 911 VASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVES 970
V S E K +Y + +VP + +R+ I G F + +++ YA F GA LV
Sbjct: 907 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAH 966
Query: 971 GHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGT 1030
F DV VF A+ + + Q SSFAPD +KAK + A I +I+K ID G
Sbjct: 967 KLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGL 1026
Query: 1031 TLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRF 1090
++++G + + F YP+RPDI + Q L+L + G+T+ALVG SG GKSTV+ LL+RF
Sbjct: 1027 MPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1086
Query: 1091 YDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN-ATEAEII 1149
YDP +G++ LDG EI++L ++WLR +G+VSQEP+LF+ +I NIAYG ++ EI+
Sbjct: 1087 YDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIV 1146
Query: 1150 AAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSAL 1209
AA+ AN FI L Y T VG++GTQLSGGQKQR+AIARA+++ P ILLLDEATSAL
Sbjct: 1147 RAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL 1206
Query: 1210 DAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
D ESE+VVQ+ALDK RT +V+AHRLST++NAD+I V +NG + E G H+ L+
Sbjct: 1207 DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1261
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1276
Score = 939 bits (2428), Expect = 0.0
Identities = 513/1254 (40%), Positives = 765/1254 (60%), Gaps = 48/1254 (3%)
Query: 37 KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGS------ 90
KEK+ V +F +A D L M+VGT+ AI +G+ LP+M ++ G M SF S
Sbjct: 27 KEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPT 86
Query: 91 ------NQTNTEDIVDQVTK--VSLKYVYLAVGSGV--AAFLQVSCWMVTGERQAARIRG 140
Q N DI ++ + + Y Y +G+GV A++QVS W + RQ +IR
Sbjct: 87 NATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQ 146
Query: 141 LYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAF 200
+ I+ Q++ +FD + GE+ R++ D I + +G+K+G F Q +ATF GGF+I F
Sbjct: 147 KFFHAIMNQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGF 205
Query: 201 TRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFT 260
TRGW LT+V+++ P+L +S A I+ K AYAKA V E+ + +IRTV +F
Sbjct: 206 TRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFG 265
Query: 261 GEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNG 320
G+K+ + Y+ +L + + G+ + + + +G L++ YALA W+G +V+ K Y+
Sbjct: 266 GQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSI 325
Query: 321 GTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDI 380
G V+ V VL + S+GQAS + AFA R AAY++F I +P ID++ NG ++I
Sbjct: 326 GQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNI 385
Query: 381 QGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQA 440
+G +E K ++FSYP+R + I G +L + SG T ALVG SG GKST + L++R YDP
Sbjct: 386 KGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTE 445
Query: 441 GEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELAN 500
G V IDG +++ VR++R IG+VSQEPVLFA++I +NI YG++ T++EI A + AN
Sbjct: 446 GVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 505
Query: 501 AAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERV 560
A FI KLP DT+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE V
Sbjct: 506 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 565
Query: 561 VQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVR 620
VQ LD+ RTT+V+AHRLSTVRNAD+IA G +V +G H EL+++ +G Y +LV
Sbjct: 566 VQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMRE-KGIYFKLVM 624
Query: 621 LQ------EINKESEETTDHHIKRELSAK-SFRQLSQRKSLQRSISRGSSIGNSSRHSFS 673
Q E+ E E+ + ++S+K S L +R+S +RSI RG + S
Sbjct: 625 TQTAGNEIELGNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSI-RGP---HDQDRKLS 680
Query: 674 VSSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPI 733
L E++P + R+ LN E P + G F AI NG + P
Sbjct: 681 TKEALD----------EDVP------PISFWRILKLNSSEWPYFVVGIFCAIVNGALQPA 724
Query: 734 FGILTSSMIKTFYEPFDEMKK--DSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQR 791
F I+ S ++ F D+ K DS ++++F++LG S + Q + F AG L +R
Sbjct: 725 FSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKR 784
Query: 792 IRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGL 851
+R + F+ ++ +V WFD P+N++G++ RL+ DA V+ G L ++ N+A +G+
Sbjct: 785 LRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGI 844
Query: 852 IIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIV 911
II+ + WQL L++L ++P+I + G V+MK + G + K E + ++A +A+ + R V
Sbjct: 845 IISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTV 904
Query: 912 ASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESG 971
S E K +Y + ++P + +++ + G F + +++ YA F GA LV
Sbjct: 905 VSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARE 964
Query: 972 HTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTT 1031
F +V VF A+ + + Q SSFAPD +KAK + + I +I+K ID G
Sbjct: 965 LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLK 1024
Query: 1032 LDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFY 1091
++++G ++ + F YP+RPDI + Q LNL + G+T+ALVG SG GKSTV+ LL+RFY
Sbjct: 1025 PNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1084
Query: 1092 DPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN-ATEAEIIA 1150
DP +G + LDG E+ QL ++WLR +G+VSQEP+LF+ +I NIAYG ++ EI
Sbjct: 1085 DPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIER 1144
Query: 1151 AAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALD 1210
AA+ AN +FI L Y+T VG++GTQLSGGQKQR+AIARA+++ P ILLLDEATSALD
Sbjct: 1145 AAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALD 1204
Query: 1211 AESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
ESE+VVQ+ALDK RT +V+AHRLST++NAD+I V++NG + E G H+ L+
Sbjct: 1205 TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLL 1258
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein 3)
Length = 1279
Score = 937 bits (2422), Expect = 0.0
Identities = 511/1239 (41%), Positives = 756/1239 (60%), Gaps = 45/1239 (3%)
Query: 48 LFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTEDIV-------- 99
LF ++D D L M +GTI AI +G GLP+M ++ G+M F N V
Sbjct: 45 LFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLN 104
Query: 100 ------DQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTF 153
+++T+ + Y L G VAA++QVS W + RQ +IR + ILRQ++ +
Sbjct: 105 PGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGW 164
Query: 154 FDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMST 213
FD T E+ R++ D I + +G+KVG F Q +ATF GF++ F RGW LT+V+M+
Sbjct: 165 FDINDTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
Query: 214 LPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHL 273
P+L +S A A I+ + K AYAKA V E+ +G+IRTV +F G+ + + Y KHL
Sbjct: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
Query: 274 VDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGTVINVIMVVLTA 333
+ + G+ + + + +G L++ YALA W+G+ +V+ K Y G + V +L
Sbjct: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
Query: 334 SMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSY 393
+ S+GQA+ + AFA R AAY +F+ I P+ID++ G + I+G +E +V+FSY
Sbjct: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
Query: 394 PARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEF 453
P+R I G +L + SG T ALVG SG GKST + L++R YDP G + IDG +++ F
Sbjct: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
Query: 454 QVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLD 513
V ++R IG+VSQEPVLF+++I +NI YG+ T++EI+ A + ANA +FI KLPQ D
Sbjct: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFD 523
Query: 514 TMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRT 573
T+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE VQ LD+ RT
Sbjct: 524 TLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRT 583
Query: 574 TVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQ----EINKESE 629
T+V+AHRLSTVRNAD+IA G +V +G+H+EL+K EG Y +LV +Q +I E
Sbjct: 584 TIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMK-KEGVYFKLVNMQTSGSQIQSEEF 642
Query: 630 ETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSFSVSSVLPTGINAIDPGL 689
E D ++ ++ R S Q+++ S + ++ GL
Sbjct: 643 ELNDEKAATRMAPNGWKSRLFRHSTQKNLKN--------------SQMCQKSLDVETDGL 688
Query: 690 E-NLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYEP 748
E N+P V ++ LNK E P + G AI NG + P F ++ S +I F P
Sbjct: 689 EANVP------PVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIF-GP 741
Query: 749 FDEMKKDSK--FWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVG 806
D+ K K ++++F+ LG S Q + F AG L +R+R + F+ ++ ++
Sbjct: 742 GDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMS 801
Query: 807 WFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIIL 866
WFD+ +NS+G++ RL+ DAA V+ G L L+ N+A +G+II+F+ WQL L++L
Sbjct: 802 WFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLL 861
Query: 867 VLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYRK 926
++P+I ++G V+MK + G + K E A ++A +A+ +IR V S E K +Y +
Sbjct: 862 AVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE 921
Query: 927 KCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALT 986
K P + +++ I G F +S ++ YA F GA L+ +GH +F DV VF A+
Sbjct: 922 KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIV 981
Query: 987 MATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRHLSF 1046
V + +SSFAPD +KAK + A +F + +++ ID E G D +G I + F
Sbjct: 982 FGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVF 1041
Query: 1047 KYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIR 1106
YP+R ++ + Q L+L + G+T+ALVG SG GKSTV+ LL+RFYDP +G + LDG E +
Sbjct: 1042 NYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAK 1101
Query: 1107 QLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN-ATEAEIIAAAELANADRFISGLQ 1165
+L ++WLR Q+G+VSQEP+LF+ +I NIAYG ++ EI++AA+ AN FI L
Sbjct: 1102 KLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLP 1161
Query: 1166 QGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALDKVM 1225
Y+T VG++GTQLSGGQKQR+AIARA+I+ P+ILLLDEATSALD ESE+VVQ+ALDK
Sbjct: 1162 HKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR 1221
Query: 1226 VNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
RT +V+AHRLST++NAD+I V +NG + E G H+ L+
Sbjct: 1222 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein 3)
(MDR1A)
Length = 1276
Score = 932 bits (2409), Expect = 0.0
Identities = 513/1257 (40%), Positives = 770/1257 (60%), Gaps = 55/1257 (4%)
Query: 37 KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGS------ 90
KEK+ V +F +A D L M+VGT+ AI +G+ LP+M ++ G M SF S
Sbjct: 27 KEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSK 86
Query: 91 NQTNTEDIVDQVTKVSLK-------YVYLAVGSGV--AAFLQVSCWMVTGERQAARIRGL 141
N TN + + L+ Y Y +G+GV A++QVS W + RQ +IR
Sbjct: 87 NSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQK 146
Query: 142 YLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFT 201
+ I+ Q++ +FD + GE+ R++ D I + +G+K+G F Q +ATF GGF+I FT
Sbjct: 147 FFHAIMNQEIGWFDVH-DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFT 205
Query: 202 RGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTG 261
RGW LT+V+++ P+L +S A I+ K AYAKA V E+ + +IRTV +F G
Sbjct: 206 RGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGG 265
Query: 262 EKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGG 321
+K+ + Y+ +L + + G+ + + + +G L++ YALA W+G +V+ K Y+ G
Sbjct: 266 QKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIG 325
Query: 322 TVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQ 381
V+ V VL + S+GQAS + AFA R AAY++F+ I +P ID++ +G ++IQ
Sbjct: 326 QVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQ 385
Query: 382 GEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAG 441
G +E K ++FSYP+R E I G +L + SG T ALVG SG GKST + L++R YDP G
Sbjct: 386 GNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDG 445
Query: 442 EVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANA 501
V IDG +++ VR++R IG+VSQEPVLFA++I +NI YG++ T++EI A + ANA
Sbjct: 446 MVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA 505
Query: 502 AKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVV 561
FI KLP DT+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE VV
Sbjct: 506 YDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 565
Query: 562 QETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRL 621
Q LD+ RTT+V+AHRLSTVRNAD+IA G +V +G H EL+++ +G Y +LV
Sbjct: 566 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMRE-KGIYFKLVMT 624
Query: 622 Q------EINKESEETTDHHIKRELSAK-SFRQLSQRKSLQRSISRGSSIGNSSRHSFSV 674
Q E+ E+ ++ D ++S+K S L +R+S ++SI
Sbjct: 625 QTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSIC--------------- 669
Query: 675 SSVLPTGINAIDPGLENLPTKEK-GQEVPLS---RLATLNKPEIPVLLFGCFAAIGNGVI 730
G + D L TKE ++VP + R+ LN E P + G F AI NG +
Sbjct: 670 ------GPHDQD---RKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGL 720
Query: 731 FPIFGILTSSMIKTFYE--PFDEMKKDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKL 788
P F ++ S ++ F P + +++S ++++F++LG S + Q + F AG L
Sbjct: 721 QPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEIL 780
Query: 789 IQRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAAL 848
+R+R + F+ ++ +V WFD+P+N++G++ RL+ DAA V+ G L ++ N+A
Sbjct: 781 TKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLG 840
Query: 849 SGLIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSI 908
+G+II+ + WQL L++L ++P+I + G V+MK + G + K E + ++A +A+ +
Sbjct: 841 TGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENF 900
Query: 909 RIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLV 968
R V S E K +Y + ++P + +++ + G F + +++ YA F GA LV
Sbjct: 901 RTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYFSYAACFRFGAYLV 960
Query: 969 ESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDES 1028
F +V VF A+ + + Q SSFAPD +KA + + I R+I+K +ID
Sbjct: 961 TQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQ 1020
Query: 1029 GTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQ 1088
G + ++G ++ F YP+RP I + Q L+L + G+T+ALVG SG GKSTV+ LL+
Sbjct: 1021 GLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1080
Query: 1089 RFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNATE-AE 1147
RFYDP +G + LDG EI+QL ++WLR Q+G+VSQEP+LF+ +I NIAYG E
Sbjct: 1081 RFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEE 1140
Query: 1148 IIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATS 1207
I+ AA+ AN +FI L Y+T VG++GTQLSGGQKQR+AIARA+++ P ILLLDEATS
Sbjct: 1141 IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS 1200
Query: 1208 ALDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
ALD ESE+VVQ+ALDK RT +V+AHRLST++NAD+I V++NG + E G H+ L+
Sbjct: 1201 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLL 1257
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein 2)
Length = 1276
Score = 929 bits (2401), Expect = 0.0
Identities = 517/1251 (41%), Positives = 760/1251 (60%), Gaps = 47/1251 (3%)
Query: 37 KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTE 96
K+K + LF ++D D L M +GT+ AI +G GLP+M ++ G+M F N N
Sbjct: 31 KKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTGNFS 90
Query: 97 DIV--------------DQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLY 142
V +++T+ + Y L G VAA++QVS W + RQ +IR +
Sbjct: 91 LPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQKF 150
Query: 143 LKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTR 202
ILRQ++ +FD + T E+ R++ D I + +G+KVG F Q IATF GF++ F R
Sbjct: 151 FHAILRQEMGWFDIKGTT-ELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIR 209
Query: 203 GWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGE 262
GW LT+V+M+ P+L +S A A I+ + K AYAKA V E+ G+IRTV +F G+
Sbjct: 210 GWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIAFGGQ 269
Query: 263 KQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGT 322
+ + Y KHL + K G+ + + + +G L++ YALA W+G+ +V+ K Y G
Sbjct: 270 NKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGN 329
Query: 323 VINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQG 382
+ V +L + S+GQA+ + AFA R AAY +F+ I P+ID++ G ++I+G
Sbjct: 330 AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDNIKG 389
Query: 383 EIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGE 442
+E +V+FSYP+R I G +L + SG T ALVG SG GKST + L++R YDP G+
Sbjct: 390 NLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGK 449
Query: 443 VLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAA 502
+ IDG +++ F VR +R IG+VSQEPVLF+++I +NI YG+ T++EI A + ANA
Sbjct: 450 ISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAY 509
Query: 503 KFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQ 562
FI KLPQ DT+VGD G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE VQ
Sbjct: 510 DFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ 569
Query: 563 ETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQ 622
LD+ RTT+V+AHRLST+RNAD+IA G +V +G+H+EL+K EG Y +LV +Q
Sbjct: 570 AALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMK-KEGIYFRLVNMQ 628
Query: 623 E-----INKESE-ETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSFSVSS 676
+++E E E +D +++ ++ R S ++S+ S H +
Sbjct: 629 TAGSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSL--------KSPH----QN 676
Query: 677 VLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGI 736
L N +D N+P V ++ LNK E P + G AI NG + P F I
Sbjct: 677 RLDEETNELD---ANVP------PVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSI 727
Query: 737 LTSSMIKTFYEPFDEMKKDSK--FWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRL 794
+ S MI F P D+ K K ++++F+ LG S Q + F AG L R+R
Sbjct: 728 ILSEMIAIF-GPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRS 786
Query: 795 LCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIA 854
+ F+ ++ ++ WFD+ +NS+G++ RL+ DAA V+ G L L+ N A +G+II+
Sbjct: 787 MAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTKLALIAQNTANLGTGIIIS 846
Query: 855 FVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASF 914
F+ WQL L++L ++P I + G V+MK + G + K E A ++A +A+ +IR V S
Sbjct: 847 FIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSL 906
Query: 915 CAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTK 974
E K +Y +K P + +R+ I G F +S ++ YA F G+ L+ +GH +
Sbjct: 907 TQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMR 966
Query: 975 FSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDS 1034
F DV VF A+ + V + +SSFAPD +KAK + A +F + +++ ID G D
Sbjct: 967 FKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDK 1026
Query: 1035 VKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPD 1094
+G + + F YP+R ++ + Q L+L + G+T+ALVG SG GKSTV+ LL+RFYDP
Sbjct: 1027 FEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPM 1086
Query: 1095 SGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNAT-EAEIIAAAE 1153
+G + LDG E ++L ++WLR Q+G+VSQEP+LF+ +I NIAYG EI+ AA+
Sbjct: 1087 AGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAK 1146
Query: 1154 LANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAES 1213
AN FI L Q Y+T VG++GTQLSGGQKQR+AIARA+I+ P++LLLDEATSALD ES
Sbjct: 1147 EANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTES 1206
Query: 1214 ERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
E+VVQ+ALDK RT +V+AHRLST++NAD+I V++NG + E G H+ L+
Sbjct: 1207 EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLL 1257
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
(P-glycoprotein 3)
Length = 1278
Score = 926 bits (2392), Expect = 0.0
Identities = 518/1253 (41%), Positives = 762/1253 (60%), Gaps = 49/1253 (3%)
Query: 37 KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTE 96
K+K + LF ++D D L M++GT AI +G GLP+M ++ G+M F N N
Sbjct: 31 KKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFS 90
Query: 97 DIV--------------DQVTKVSLKYVYLAVGSGV--AAFLQVSCWMVTGERQAARIRG 140
V +++T+ + Y Y +G GV AA++QVS W + RQ +IR
Sbjct: 91 LPVNFSLSMLNPGRILEEEMTRYA--YYYSGLGGGVLLAAYIQVSFWTLAAGRQIRKIRQ 148
Query: 141 LYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAF 200
+ ILRQ++ +FD + T E+ R++ D I + +G+KVG F Q IATF GF++ F
Sbjct: 149 KFFHAILRQEMGWFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGF 207
Query: 201 TRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFT 260
RGW LT+V+M+ +L +S A A I+ + K AYAKA V E+ +G+IRTV +F
Sbjct: 208 IRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFG 267
Query: 261 GEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNG 320
G+ + + Y KHL + K G+ + + + +G L++ YALA W+G+ +V+ K Y
Sbjct: 268 GQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTI 327
Query: 321 GTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDI 380
G + V +L + S+GQA+ + AF R AAY +F+ I P+ID++ G + I
Sbjct: 328 GNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSI 387
Query: 381 QGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQA 440
+G +E +V+FSYP+R I G +L + SG T ALVG SG GKST + L++R YDP
Sbjct: 388 KGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTE 447
Query: 441 GEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELAN 500
G + IDG +++ F VR +R IG+VSQEPVLF+++I +NI YG+ T++EI+ A + AN
Sbjct: 448 GTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEAN 507
Query: 501 AAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERV 560
A FI KLPQ DT+VGD G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE
Sbjct: 508 AYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 567
Query: 561 VQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVR 620
VQ LD+ RTT+V+AHRLSTVRNAD+IA G +V +G+H+EL+K EG Y +LV
Sbjct: 568 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIK-KEGIYFRLVN 626
Query: 621 LQE-----INKESE-ETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSFSV 674
+Q +++E E E +D ++ ++ R S ++S+ SS + +R
Sbjct: 627 MQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLK--SSRAHQNR----- 679
Query: 675 SSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIF 734
L N +D N+P V ++ LNK E P + G AI NG + P F
Sbjct: 680 ---LDVETNELD---ANVP------PVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAF 727
Query: 735 GILTSSMIKTFYEPFDEMKKDSK--FWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRI 792
I+ S MI F P D+ K K ++++F+ LG S Q + F AG L R+
Sbjct: 728 SIILSEMIAIF-GPGDDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRL 786
Query: 793 RLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLI 852
R + F+ ++ ++ WFD+ +NS+G++ RL+ DAA V+ G L L+ N A +G+I
Sbjct: 787 RSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGII 846
Query: 853 IAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVA 912
I+F+ WQL L++L ++P I + G V+MK + G + K E A ++A +A+ +IR V
Sbjct: 847 ISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVV 906
Query: 913 SFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGH 972
S E K +Y +K P + +R+ I G F +S ++ YA F G+ L+ +GH
Sbjct: 907 SLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGH 966
Query: 973 TKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTL 1032
+F DV VF A+ + V + +SSFAPD +KAK + A +F + +++ ID G
Sbjct: 967 MRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWP 1026
Query: 1033 DSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYD 1092
D +G + + F YP+R ++ + Q L+L + G+T+ALVG SG GKSTV+ LL+RFYD
Sbjct: 1027 DKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYD 1086
Query: 1093 PDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN-ATEAEIIAA 1151
P +G + LDG E ++L ++WLR Q+G+VSQEP+LF+ +I NIAYG ++ EI+ A
Sbjct: 1087 PMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRA 1146
Query: 1152 AELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDA 1211
A+ AN FI L Q Y+T VG++GTQLSGGQKQR+AIARA+I+ P++LLLDEATSALD
Sbjct: 1147 AKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDT 1206
Query: 1212 ESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
ESE+VVQ+ALDK RT +V+AHRLST++NAD+I V+ NG + E G H+ L+
Sbjct: 1207 ESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLL 1259
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein 3)
Length = 1281
Score = 921 bits (2381), Expect = 0.0
Identities = 514/1256 (40%), Positives = 755/1256 (59%), Gaps = 55/1256 (4%)
Query: 37 KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTE 96
K+K + LF ++D D L M++GTI AI +G GLP+M ++ G+M F +N N
Sbjct: 34 KKKVNLIGPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVNNAGNFS 93
Query: 97 DIV--------------DQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLY 142
V +++T+ + Y L G VAA++QVS W + RQ +IR +
Sbjct: 94 LPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNF 153
Query: 143 LKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTR 202
ILRQ++ +FD + T E+ R++ D I + +G+KVG F Q +ATF GF++ F R
Sbjct: 154 FHAILRQEMGWFDIKGTT-ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIR 212
Query: 203 GWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGE 262
GW LT+V+M+ P+L +S A A I+ + K AYAKA V E+ +G+IRTV +F G+
Sbjct: 213 GWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQ 272
Query: 263 KQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGT 322
+ + Y KHL + K G+ + + + +G L++ YALA W+G+ +V+ K Y G
Sbjct: 273 NKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGN 332
Query: 323 VINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQG 382
+ V +L + S+GQA+ + AFA R AAY +F+ I P+ID++ G + I+G
Sbjct: 333 AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKG 392
Query: 383 EIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGE 442
++ +V+FSYP+R I G +L + SG T ALVG SG GK+T + L++R YDP G
Sbjct: 393 NLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGT 452
Query: 443 VLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAA 502
+ IDG +++ F VR++R IG+VSQEPVLF+++I +NI YG+ T+EEI+ A + ANA
Sbjct: 453 ISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAY 512
Query: 503 KFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQ 562
+FI KLPQ DT+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE VQ
Sbjct: 513 EFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ 572
Query: 563 ETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQ 622
LD+ RTT+V+AHRLSTVRNAD+IA G +V +G+H+EL++ EG Y +LV +Q
Sbjct: 573 AALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQ-KEGVYFKLVNMQ 631
Query: 623 -----------EINKESEETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHS 671
E+ E+ D + FR S +KSL+ S + H
Sbjct: 632 TSGSQILSQEFEVELSEEKAADGMTPNGWKSHIFRN-STKKSLKSS--------RAHHHR 682
Query: 672 FSVSSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIF 731
V + D N+P V ++ LNK E P + G AI NG +
Sbjct: 683 LDVDA---------DELDANVP------PVSFLKVLKLNKTEWPYFVVGTVCAIVNGALQ 727
Query: 732 PIFGILTSSMIKTFYEPFDEMKKDSK--FWAVMFMLLGFASLLVVTAQSYFFSVAGYKLI 789
P I+ S MI F P D+ K K ++++F+ LG S Q + F AG L
Sbjct: 728 PAISIILSEMIAIF-GPGDDAVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEILT 786
Query: 790 QRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALS 849
R+R + F+ ++ ++ WFD+ +NS+G++ RL+ D A V+ G L L+ N A +
Sbjct: 787 TRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANLGT 846
Query: 850 GLIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIR 909
G+II+F+ WQL L++L ++P I ++G V+MK + G + K E A ++A +A+ +IR
Sbjct: 847 GIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIR 906
Query: 910 IVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVE 969
V S E K +Y +K P + ++ I G F +S ++ YA F GA L+
Sbjct: 907 TVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGAYLIV 966
Query: 970 SGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESG 1029
+GH +F DV VF A+ V + +SSFAPD +KAK + A +F + +++ ID G
Sbjct: 967 NGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEG 1026
Query: 1030 TTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQR 1089
D +G + + F YP+R ++ + Q L+L + G+T+ALVG SG GKSTV+ LL+R
Sbjct: 1027 LWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1086
Query: 1090 FYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN-ATEAEI 1148
FYDP +G + LDG E ++L ++WLR Q+G+VSQEPVLF+ +I NIAYG ++ EI
Sbjct: 1087 FYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEI 1146
Query: 1149 IAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSA 1208
+ AA+ AN FI L Q Y T VG++GTQLSGGQKQR+AI RA+I+ P++LLLDEATSA
Sbjct: 1147 VRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSA 1206
Query: 1209 LDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
LD ESE+VVQ+ALDK RT +V+AHRLST++NAD+I V++NG + E G H+ L+
Sbjct: 1207 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLL 1262
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1276
Score = 909 bits (2349), Expect = 0.0
Identities = 507/1277 (39%), Positives = 770/1277 (59%), Gaps = 51/1277 (3%)
Query: 17 ENNRTETSTNATTNGEKDIT--KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGL 74
EN + N + G+K KEK+ V +F +AD D L MI+GT+ AI +G L
Sbjct: 5 ENLKGRADKNFSKMGKKSKKEKKEKKPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLL 64
Query: 75 PIMTVLLGQMIHSFGSNQTNT-EDIVDQ--------VTKVSLK-------YVYLAVGSGV 118
P++ ++ G M SF + + I +Q ++ SL+ Y Y +G+GV
Sbjct: 65 PLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGV 124
Query: 119 --AAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQD 176
A++QVS W + RQ +IR + I+ Q++ +FD + GE+ R++ D I D
Sbjct: 125 LIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH-DVGELNTRLTDDVSKIND 183
Query: 177 AMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQ 236
+G+K+G F Q I TF+ GF+I F GW LT+V+++ PL+ +S A A ++ +K
Sbjct: 184 GIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKEL 243
Query: 237 TAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMF 296
AYAKA V E+ + +IRTV +F G+++ + Y+K+L + G+ + + + +G
Sbjct: 244 QAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYL 303
Query: 297 LMFLGYALAVWFGAKMVMEKGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYK 356
L++ YALA W+G +V+ Y+ G V+ V +L + S+G + + AFA R AA++
Sbjct: 304 LVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFE 363
Query: 357 MFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTA 416
+F+ I P ID++ G + I G +E K V+F+YP+R E I G +L + SG T A
Sbjct: 364 IFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVA 423
Query: 417 LVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSI 476
LVG SG GKST + L++R YDP G V IDG +++ VR++R IG+VSQEPVLFA++I
Sbjct: 424 LVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTI 483
Query: 477 KDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARA 536
+NI YG++ T++EI A + ANA FI KLP DT+VG+ G+QLSGGQKQRIAIARA
Sbjct: 484 AENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARA 543
Query: 537 ILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRG 596
+++NP+ILLLDEATSALD +SE VVQ LD+ RTT+V+AHRLSTVRNAD+IA G
Sbjct: 544 LVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGG 603
Query: 597 KMVSKGTHTELLKDPEGAYSQLVRLQEINKESEETTDHHIKR------ELSAKSFRQLSQ 650
+V +G H EL+++ +G Y +LV Q E E + + + EL+++ +
Sbjct: 604 VIVEQGNHDELMRE-KGIYFKLVMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLI 662
Query: 651 RKSLQRSISRGSSIGNSSRHSFSVSSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLN 710
R+S+ RS+ R R S A+D E++P V R+ LN
Sbjct: 663 RRSIYRSVHRKQD--QERRLSMK---------EAVD---EDVPL------VSFWRILNLN 702
Query: 711 KPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYEPFDE--MKKDSKFWAVMFMLLGF 768
E P LL G A+ NG I P+F I+ S ++ F D +++ +++ F+++G
Sbjct: 703 LSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNLFSLFFLVMGL 762
Query: 769 ASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAAS 828
S + Q + F AG L +R+R + F+ ++ ++ WFD+ +NS+GS+ RL++DA+S
Sbjct: 763 ISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASS 822
Query: 829 VRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSA 888
V+ +G L ++ N+A +G+I++ V WQL L+++V+IPLI L G ++MK + G +
Sbjct: 823 VKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQAL 882
Query: 889 DAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGV 948
K E + ++A +A+ + R + S E K +Y + +VP + +++ + G F
Sbjct: 883 KDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSF 942
Query: 949 SFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSA 1008
+ +++ YA F GA LV F +V VF A+ + +SSFAPD +KAK +
Sbjct: 943 TQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVS 1002
Query: 1009 TASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGK 1068
+ I R+I+K +ID G ++G ++ + F YP+RP+I + Q L+L + G+
Sbjct: 1003 ASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQ 1062
Query: 1069 TVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFN 1128
T+ALVG SG GKSTV+ LL+RFYDP +G + LDG EI+QL ++WLR +G+VSQEP+LF+
Sbjct: 1063 TLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFD 1122
Query: 1129 DTIRSNIAYGKGGNA-TEAEIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRV 1187
+I NIAYG A + EI+ AA+ AN +FI L Y+T VG++GTQLSGGQKQR+
Sbjct: 1123 CSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRI 1182
Query: 1188 AIARAIIKSPKILLLDEATSALDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIA 1247
AIARA+++ P ILLLDEATSALD ESE+VVQ+ALDK RT +V+AHRLST++NAD+I
Sbjct: 1183 AIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1242
Query: 1248 VVKNGVIVEKGRHETLI 1264
V++NG + E G H+ L+
Sbjct: 1243 VIENGKVKEHGTHQQLL 1259
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein 2)
Length = 1276
Score = 900 bits (2326), Expect = 0.0
Identities = 501/1262 (39%), Positives = 759/1262 (59%), Gaps = 60/1262 (4%)
Query: 37 KEKQE----TVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGS-- 90
KEK+E V +F +AD D L M++GT+ A+ +G LP++ ++ G M SF
Sbjct: 24 KEKKEKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAE 83
Query: 91 -----NQTNTEDIVD-QVTKVSLK-------YVYLAVGSGV--AAFLQVSCWMVTGERQA 135
N TN +I + +V SL+ Y Y +G+GV A++QVS W + RQ
Sbjct: 84 TSIWPNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQI 143
Query: 136 ARIRGLYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGG 195
+IR + I+ Q++ +FD + GE+ R++ D I D +G+K+G F Q IATF+
Sbjct: 144 NKIRQKFFHAIMNQEIGWFDVH-DIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAA 202
Query: 196 FVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRT 255
F++ F GW LT+V+++ PL+ +S A A ++ +K AYAKA V E+ + +IRT
Sbjct: 203 FIVGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRT 262
Query: 256 VASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVME 315
V +F G+ + + Y+K+L + G+ + + + +G L++ YALA W+G +V+
Sbjct: 263 VIAFGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLS 322
Query: 316 KGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGK 375
Y+ G V+ V +L + S+G + + FA R AAY++F+ I P ID++ G
Sbjct: 323 NEYSVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGH 382
Query: 376 ILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERF 435
+ + G +E K V+FSYP+R I G +L + SG T ALVG+SG GKST + L++R
Sbjct: 383 KPDSVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRL 442
Query: 436 YDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSA 495
YDP G V IDG +++ VR++R IG+VSQEPVLFA++I +NI YG++ T++EI A
Sbjct: 443 YDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKA 502
Query: 496 SELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDA 555
+ ANA FI KLP DT+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD
Sbjct: 503 VKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDT 562
Query: 556 KSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAY 615
+SE VVQ LD+ RTT+V+AHRLSTVRNAD+IA G +V +G H EL+K+ +G Y
Sbjct: 563 ESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKE-KGIY 621
Query: 616 SQLVRLQ------EINKESEETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSR 669
+LV +Q E+ E++ + I EL+++ F+ S RKS RSI G+ +
Sbjct: 622 CRLVMMQTRGNEVELGSEADGSQSDTIASELTSEEFKSPSVRKSTCRSIC-----GSQDQ 676
Query: 670 HSFSVSSVLPTGINAIDPGLENLPTKE-KGQEVPLSR---LATLNKPEIPVLLFGCFAAI 725
+ KE + ++VPL + LN E P L+ G A+
Sbjct: 677 E-------------------RRVSVKEAQDEDVPLVSFWGILKLNITEWPYLVVGVLCAV 717
Query: 726 GNGVIFPIFGILTSSMIKTFYEPFDEMKKDSK--FWAVMFMLLGFASLLVVTAQSYFFSV 783
NG + P+F I+ S +I F D K +++ F+++G + Q + F
Sbjct: 718 INGCMQPVFSIVFSGIIGVFTRDDDPKTKQQNCNLFSLFFLVMGMICFVTYFFQGFTFGK 777
Query: 784 AGYKLIQRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMN 843
AG L +R+R + F+ ++ ++ WFD+ NS+G++ RL++DAA+V+ + L + N
Sbjct: 778 AGEILTKRLRYMVFKSMLRQDISWFDDHRNSTGALTTRLASDAANVKGAMSSRLAGITQN 837
Query: 844 LAAALSGLIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVAND 903
+A +G+II+ V WQL L+++V+ PLI L+G ++MK + G + K E + ++A +
Sbjct: 838 VANLGTGIIISLVYGWQLTLLLVVIAPLIILSGMMEMKVLSGQALKDKKELEVSGKIATE 897
Query: 904 AVGSIRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYA 963
A+ + R V S E K +Y + ++P + +++ + G F + +++ YA F
Sbjct: 898 AIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRF 957
Query: 964 GARLVESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKID 1023
GA LV F +V VF A+ + +SSFAPD +KAK + + I R+++K ID
Sbjct: 958 GAYLVAHQIMTFENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHIIRIMEKIPSID 1017
Query: 1024 PSDESGTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTV 1083
G + ++G ++ + F YP+RPDI + Q L+L + G+T+ALVG SG GKSTV
Sbjct: 1018 SYSTRGLKPNWLEGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1077
Query: 1084 IALLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN- 1142
+ LL+RFYDP +G + LDG EI+QL ++WLR +G+VSQEP+LF+ +I NIAYG
Sbjct: 1078 VQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1137
Query: 1143 ATEAEIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLL 1202
++ EI AA+ AN +FI L Y+T VG++GTQLSGGQKQR+AIARA+++ P ILLL
Sbjct: 1138 VSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1197
Query: 1203 DEATSALDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHET 1262
DEATSALD ESE+VVQ+ALDK RT +V+AHRLST++NAD+I V++NG + E G H+
Sbjct: 1198 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQ 1257
Query: 1263 LI 1264
L+
Sbjct: 1258 LL 1259
>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1277
Score = 887 bits (2292), Expect = 0.0
Identities = 496/1258 (39%), Positives = 754/1258 (59%), Gaps = 53/1258 (4%)
Query: 37 KEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQ---- 92
KEK+ V +F +AD D L M +GT+ AI +G LP++ ++ G M SF ++
Sbjct: 26 KEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHS 85
Query: 93 ----TNTEDI--VDQVTKVSLK-------YVYLAVGSGV--AAFLQVSCWMVTGERQAAR 137
TN +I V+ SL+ Y Y +G+GV A++QVS W + RQ +
Sbjct: 86 DRAITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHK 145
Query: 138 IRGLYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFV 197
IR + I+ Q++ +FD + GE+ R++ D I D +G+K+G F Q I TF GF+
Sbjct: 146 IRQKFFHAIMNQEIGWFDVN-DAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFI 204
Query: 198 IAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVA 257
I F GW LT+V+++ PL+ +S A A ++ +K AYAKA V E+ + +IRTV
Sbjct: 205 IGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVI 264
Query: 258 SFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKG 317
+F G+K+ + Y+K+L + + G+ + + + +G L++ YALA W+G +V+
Sbjct: 265 AFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNE 324
Query: 318 YNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKIL 377
Y+ G V+ V +L + S+G + + AFA R AAY++F+ I P ID++ G
Sbjct: 325 YSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKP 384
Query: 378 EDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYD 437
+ I G +E K VYF+YP+R E I G +L + SG T ALVG SG GKST + L++R YD
Sbjct: 385 DSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYD 444
Query: 438 PQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASE 497
P GEV IDG +++ VR++R IG+VSQEPVLFA++I +NI YG++ T++EI A +
Sbjct: 445 PIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVK 504
Query: 498 LANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKS 557
ANA FI KLP DT+VG+ G+QLSGGQKQRIAIARA+++NP+ILLLDEATSALD +S
Sbjct: 505 EANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 564
Query: 558 ERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQ 617
E VVQ LD+ RTT+V+AHRLSTVRNAD+IA G +V +G H EL+K+ +G Y +
Sbjct: 565 EAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKE-KGIYFK 623
Query: 618 LVRLQEINKESE------ETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHS 671
LV Q E E E+ EL+++ + R+S++RSI R
Sbjct: 624 LVMTQTRGNEIEPGNNAYESQSDTGASELTSEESKSPLIRRSIRRSIHRRQDQERRLSSK 683
Query: 672 FSVSSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIF 731
V +P V ++ LN E P L+ G A+ NG I
Sbjct: 684 EDVDEDVPM--------------------VSFWQILKLNISEWPYLVVGVLCAVINGCIQ 723
Query: 732 PIFGILTSSMIKTFYEPFDE--MKKDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLI 789
P+F I+ S ++ F D +++ ++++F+++G S + Q + F AG L
Sbjct: 724 PVFAIVFSKIVGVFSRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILT 783
Query: 790 QRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALS 849
+R+R + F+ ++ ++ WFD+ +N++GS+ RL++DA++V+ +G L ++ N+A +
Sbjct: 784 KRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGT 843
Query: 850 GLIIAFVA--SWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGS 907
G+I++ V WQL L+++V+IPLI L G ++MK + G + K E + ++A +A+ +
Sbjct: 844 GIILSLVLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAIEN 903
Query: 908 IRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARL 967
R V S E K +Y + ++P + +++ + G F + +++ YA F GA L
Sbjct: 904 FRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGAYL 963
Query: 968 VESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDE 1027
V F +V VF A+ + +SSFAPD +KAK + + I +I+K +ID
Sbjct: 964 VARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEIDSYST 1023
Query: 1028 SGTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALL 1087
G + ++G ++ + F YP+RP+I + Q L+ + G+T+ LVG SG GKSTV+ LL
Sbjct: 1024 EGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLL 1083
Query: 1088 QRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGN-ATEA 1146
+RFY+P +G + LDG EI+QL ++ +R +G+VSQEP+LF+ +I NIAYG +
Sbjct: 1084 ERFYNPMAGTVFLDGKEIKQLNVQCVR-ALGIVSQEPILFDCSIAENIAYGDNSRVVSHE 1142
Query: 1147 EIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEAT 1206
EI+ AA AN +FI L + Y+T VG++GTQLSGGQKQR+AIARA+++ P ILLLDEAT
Sbjct: 1143 EIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1202
Query: 1207 SALDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
SALD ESE+VVQ+ALDK RT VV+AHRLST++NAD+I V++NG + E G H+ L+
Sbjct: 1203 SALDTESEKVVQEALDKAREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLL 1260
>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11)
Length = 1321
Score = 882 bits (2278), Expect = 0.0
Identities = 497/1291 (38%), Positives = 763/1291 (58%), Gaps = 45/1291 (3%)
Query: 17 ENNRTETSTNATTNGEKDITKEKQET---VPFHKLFSFADSTDILLMIVGTIGAIGNGLG 73
EN+ E+ + + + + EK+ V F +LF F+ STDI LM VG++ A +G+
Sbjct: 16 ENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIA 75
Query: 74 LPIMTVLLGQMIHSF-----------------------------GSNQTNTE-----DIV 99
P + ++ G M F N TN +I
Sbjct: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
Query: 100 DQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETN 159
++ K + Y +AV + ++Q+ W++ RQ ++R Y + I+R ++ +FD +
Sbjct: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNS- 194
Query: 160 TGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVV 219
GE+ R S D I DA+ +++ F+Q + + + GF++ F RGW LT+V++S PL+ +
Sbjct: 195 VGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGI 254
Query: 220 SGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKS 279
A + + + + AYAKA V ++ I S+RTVA+F GEK+ V Y K+LV +
Sbjct: 255 GAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRW 314
Query: 280 GVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKG-YNGGTVINVIMVVLTASMSLG 338
G+ +G + G G L+FL YA+A W+G+ +V+++G Y GT++ + + V+ +++LG
Sbjct: 315 GIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLG 374
Query: 339 QASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARPE 398
AS L AFA GRAAA +FETI R+P ID +G L+ I+GEIE V F YP+RPE
Sbjct: 375 NASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPE 434
Query: 399 ELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWI 458
I N ++ I G TALVG SG+GKST + L++RFYDP G V +DG +++ ++W+
Sbjct: 435 VKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWL 494
Query: 459 RGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVGD 518
R +IG+V QEPVLF+++I +NI YG++ AT+E+I A++ ANA FI LPQ DT+VG+
Sbjct: 495 RDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 519 HGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVVA 578
G Q+SGGQKQR+AIARA+++NP+ILLLD ATSALD +SE +VQE L +I T + VA
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVA 614
Query: 579 HRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINKE--SEETTDHHI 636
HRLSTVR AD I G V +GTH ELL + +G Y LV LQ + +EE
Sbjct: 615 HRLSTVRAADTIIGFEHGTAVERGTHEELL-ERKGVYFTLVTLQSQGNQALNEEDIKDAT 673
Query: 637 KRELSAKSFRQLSQRKSLQRSI-SRGSSIGNSSRHSFSVSSVLPTGINAIDPGLENLPTK 695
+ ++ A++F + S + SL+ SI R S + H ++ V D +++P +
Sbjct: 674 EDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQ 733
Query: 696 EKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYEP-FDEMKK 754
E+ + P+ R+ + PE P +L G A NG + P++ L S ++ TF P +E +
Sbjct: 734 EEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRS 793
Query: 755 DSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPENS 814
++F+ +G SL Q Y F+ +G L +R+R F ++ ++ WFD+ NS
Sbjct: 794 QINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNS 853
Query: 815 SGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIGL 874
G++ RL+ DA+ V+ G +G++V + +IIAF SW+L+L+IL P + L
Sbjct: 854 PGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLAL 913
Query: 875 NGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYRKKCEVPMKT 934
+G Q + + GF++ K E Q+ N+A+ +IR VA E + +E + E P KT
Sbjct: 914 SGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKT 973
Query: 935 GIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALTMATVGISQ 994
I++ I G F + ++F + S+ G L+ + FS VFRV A+ ++ + +
Sbjct: 974 AIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGR 1033
Query: 995 SSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRHLSFKYPSRPDI 1054
+ S+ P +KAK + A F+++D++ I + +G D+ +G+I+ F YPSRPD
Sbjct: 1034 AFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDS 1093
Query: 1055 QIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLKWLR 1114
Q+ L+++I G+T+A VG SG GKST I LL+RFYDPD G++ +DG + +++ +++LR
Sbjct: 1094 QVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLR 1153
Query: 1115 QQMGLVSQEPVLFNDTIRSNIAYGKGGNATEAE-IIAAAELANADRFISGLQQGYDTIVG 1173
+G+VSQEPVLF +I NI YG E +IAAA+ A F+ L + Y+T VG
Sbjct: 1154 SNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVG 1213
Query: 1174 ERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALDKVMVNRTTVVV 1233
+G+QLS G+KQR+AIARAI++ PKILLLDEATSALD ESE+ VQ ALDK RT +V+
Sbjct: 1214 SQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVI 1273
Query: 1234 AHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
AHRLST++NAD+IAV+ GV++EKG HE L+
Sbjct: 1274 AHRLSTIQNADIIAVMAQGVVIEKGTHEELM 1304
Score = 379 bits (973), Expect = e-104
Identities = 218/600 (36%), Positives = 347/600 (57%), Gaps = 8/600 (1%)
Query: 24 STNATTNGEKDI-TKEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLG 82
ST +KDI +E+ E P ++ F+ + + M+VG++GA NG P+ L
Sbjct: 719 STYEEDRKDKDIPVQEEVEPAPVRRILKFS-APEWPYMLVGSVGAAVNGTVTPLYAFLFS 777
Query: 83 QMIHSFGSNQTNTEDIVDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLY 142
Q++ +F + E+ Q+ V L +V + S FLQ + +GE R+R
Sbjct: 778 QILGTFSI--PDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFG 835
Query: 143 LKTILRQDVTFFDKETNT-GEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFT 201
+ +L QD+ +FD N+ G + R++ D +Q A G ++G + +IAF+
Sbjct: 836 FRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFS 895
Query: 202 RGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTG 261
W L++V++ P L +SGA ++ AS+ + A + + + +IRTVA
Sbjct: 896 FSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGK 955
Query: 262 EKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGG 321
E++ + L +K+ + + I G +MF+ + + +G ++ +G +
Sbjct: 956 ERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFS 1015
Query: 322 TVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQ 381
V VI V+ ++ +LG+A S ++A + +A + F+ + R+P I Y+ G+ ++ Q
Sbjct: 1016 YVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQ 1075
Query: 382 GEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAG 441
G+I+ + F+YP+RP+ + NG S+ I G T A VG SG GKST I L+ERFYDP G
Sbjct: 1076 GKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQG 1135
Query: 442 EVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATI--EEIRSASELA 499
+V+IDG + K+ V+++R IG+VSQEPVLFA SI DNI YG + I E + +A++ A
Sbjct: 1136 KVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQA 1195
Query: 500 NAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSER 559
F+ LP+ +T VG GSQLS G+KQRIAIARAI+++P+ILLLDEATSALD +SE+
Sbjct: 1196 QLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
Query: 560 VVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLV 619
VQ LD+ RT +V+AHRLST++NAD+IA++ +G ++ KGTH EL+ +GAY +LV
Sbjct: 1256 TVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQ-KGAYYKLV 1314
>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 877 bits (2266), Expect = 0.0
Identities = 497/1302 (38%), Positives = 766/1302 (58%), Gaps = 66/1302 (5%)
Query: 17 ENNRTETSTNATTNGEK----DITKEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGL 72
E N S + N +K D KE V F +LF F+ S DI LM++G + A+ +G+
Sbjct: 15 EENHAFESDGSHNNDKKSRLQDKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGM 74
Query: 73 GLPIMTVLLGQMIH-----------------------------SFGSNQTNTE-----DI 98
P + ++ G M SF N TN DI
Sbjct: 75 AQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDI 134
Query: 99 VDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKET 158
++ K S Y + + + + Q+ W++TG RQ R+R +Y + I+R ++ +FD T
Sbjct: 135 ESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDC-T 193
Query: 159 NTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLV 218
+ GE+ R + D I DA+ +++ FLQ ++T + G ++ F RGW LT+V+++ PL+
Sbjct: 194 SVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIG 253
Query: 219 VSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYK 278
+ A + + I + AYAKA + ++ + SIRTVA+F GE + V Y K+LV +
Sbjct: 254 IGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQR 313
Query: 279 SGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVM-EKGYNGGTVINVIMVVLTASMSL 337
G+++G + G G L+F YALA W+G+ +V+ E+ Y GT++ + + V+ A+M++
Sbjct: 314 WGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNI 373
Query: 338 GQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARP 397
G ASS L F+ G +AA +F+TI R+P ID +G L+ I+GEIE V F YP+RP
Sbjct: 374 GHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 398 EELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRW 457
+ I + S+ I G TTALVG SG+GKST + L++RFYDP G V +DG +++ +RW
Sbjct: 434 DVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRW 493
Query: 458 IRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVG 517
+R +IG+V QEPVLF+++I +NI +G++ AT+E+I A++ ANA FI LPQ DT+VG
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVG 553
Query: 518 DHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVV 577
+ G Q+SGGQKQR+AIARA+++NP+ILLLD ATSALD +SE VQE L++I T + V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISV 613
Query: 578 AHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINKESEETTDHHIK 637
AHRLSTVR AD+I G V +GTH ELL + +G Y LV LQ + + T
Sbjct: 614 AHRLSTVRAADVIIGFEHGVAVERGTHEELL-ERKGVYFMLVTLQSQGDNAHKET----- 667
Query: 638 RELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSFSVSSVLPTGINAIDPGL-------- 689
+ + ++ +L+R+ SRG S +S R S S + DP L
Sbjct: 668 ----SIMGKDATEGGTLERTFSRG-SYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSS 722
Query: 690 -----ENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKT 744
+N E+ + P+ R+ N PE +L G +A NG + PI+ +L S ++ T
Sbjct: 723 YKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGT 782
Query: 745 F-YEPFDEMKKDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSM 803
F ++ + + + F++LG S+ Q Y F+ +G L +R+R F+ ++
Sbjct: 783 FSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQ 842
Query: 804 EVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLAL 863
++GWFD+ N+ G + RL+ DA+ V+ G +G++V + ++ L+IAF SW+L+L
Sbjct: 843 DIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSL 902
Query: 864 IILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMEL 923
II + P + L+G VQ K + GF++ K E+A Q+ ++A+ +IR VA E + ++
Sbjct: 903 IITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKA 962
Query: 924 YRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFF 983
+ + + KT +R+ I G F S + F + ++ G L+ FS VFRV
Sbjct: 963 FEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVS 1022
Query: 984 ALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRH 1043
++ ++ + ++ S+ P +KAK + A F+++D+K I+ E+G D+ +G+I+
Sbjct: 1023 SVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFID 1082
Query: 1044 LSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGI 1103
F YPSRPDIQ+ L+++++ G+T+A VG SG GKST I LL+RFYDPD G + +DG
Sbjct: 1083 CKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGH 1142
Query: 1104 EIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNATEAE-IIAAAELANADRFIS 1162
+ +++ +++LR +G+VSQEPVLF+ +I NI YG E IAAA+ A F+
Sbjct: 1143 DSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVM 1202
Query: 1163 GLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALD 1222
L + Y+T VG +G+QLS G+KQR+AIARAI++ PKILLLDEATSALD ESE+ VQ ALD
Sbjct: 1203 SLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALD 1262
Query: 1223 KVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
K RT +V+AHRLST++N+D+IAVV GV++EKG HE L+
Sbjct: 1263 KAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLM 1304
Score = 363 bits (932), Expect = 2e-99
Identities = 208/591 (35%), Positives = 338/591 (56%), Gaps = 7/591 (1%)
Query: 32 EKDITKEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSN 91
+ D+ E+ E P ++ + + + ++VG++ A NG PI ++L Q++ +F +
Sbjct: 728 DNDVLVEEVEPAPVRRILKY-NIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTF--S 784
Query: 92 QTNTEDIVDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDV 151
+ E ++ + L +V L S FLQ + +GE R+R K +L QD+
Sbjct: 785 LLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDI 844
Query: 152 TFFDK-ETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVL 210
+FD N G + R++ D +Q A G +VG + + +IAF W L++++
Sbjct: 845 GWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLII 904
Query: 211 MSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYS 270
P L +SGA ++ AS+ + A KA + + + +IRTVA E + + +
Sbjct: 905 TIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFE 964
Query: 271 KHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGTVINVIMVV 330
L YK+ V + I G+ + FL + A +G ++ +G V V+ V
Sbjct: 965 VELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSV 1024
Query: 331 LTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVY 390
++ ++G+ S ++A + +A + F+ + R+P I+ Y G+ ++ QG+I+ +
Sbjct: 1025 ALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCK 1084
Query: 391 FSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINM 450
F+YP+RP+ + NG S+ + G T A VG SG GKST I L+ERFYDP G V+IDG +
Sbjct: 1085 FTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDS 1144
Query: 451 KEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGA--TIEEIRSASELANAAKFIDKL 508
K+ ++++R IG+VSQEPVLF SI DNI YG + ++E +A++ A F+ L
Sbjct: 1145 KKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSL 1204
Query: 509 PQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRI 568
P+ +T VG GSQLS G+KQRIAIARAI+++P+ILLLDEATSALD +SE+ VQ LD+
Sbjct: 1205 PEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKA 1264
Query: 569 MVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLV 619
RT +V+AHRLST++N+D+IA++ +G ++ KGTH +L+ +GAY +LV
Sbjct: 1265 REGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQ-KGAYYKLV 1314
>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 870 bits (2249), Expect = 0.0
Identities = 496/1302 (38%), Positives = 769/1302 (58%), Gaps = 64/1302 (4%)
Query: 17 ENNRTETSTNATTNGEKDITKEKQE----TVPFHKLFSFADSTDILLMIVGTIGAIGNGL 72
E N S N +K ++K++ V F +LF F+ S D LM +G++ A+ +G+
Sbjct: 15 EENHAFESDGFHNNDKKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGM 74
Query: 73 GLPIMTVLLGQMIH-----------------------------SFGSNQTNTE-----DI 98
P M ++ G + SF N TN DI
Sbjct: 75 AQPGMIIVFGILTDIFVEYDIERQELSIPGKVCMNNTIVWINSSFNQNMTNGTSCGLVDI 134
Query: 99 VDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKET 158
+V K S Y + V + + Q+ W++TG RQ ++R Y + I+R ++ +FD T
Sbjct: 135 NSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDC-T 193
Query: 159 NTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLV 218
+ GE+ R S D I +A+ +++ FLQ ++T + G ++ F RGW LT+V+++ PL+
Sbjct: 194 SVGELNSRFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIG 253
Query: 219 VSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYK 278
+ A + + + + AYAKA + ++ + SIRTVA+F GE + V Y K+L+ +
Sbjct: 254 IGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQR 313
Query: 279 SGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKG-YNGGTVINVIMVVLTASMSL 337
G+++G + G G L+F YALA W+G+++V+++G Y GT+I + + V+ A+M++
Sbjct: 314 WGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNI 373
Query: 338 GQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARP 397
G ASS L F+ G +AA +F+TI R+P +D +G L+ I+GEIE V F YP+RP
Sbjct: 374 GNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 398 EELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRW 457
E I N S+ I G TTA VG SG+GKST + L++RFYDP G V +DG +++ +RW
Sbjct: 434 EVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRW 493
Query: 458 IRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVG 517
+R +IG+V QEPVLF+++I +NI G++ AT+E+I A++ ANA FI LPQ DT+VG
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVG 553
Query: 518 DHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVV 577
+ G Q+SGGQKQR+AIARA+++ P+ILLLD ATSALD +SE VQ L++I T + V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISV 613
Query: 578 AHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINKESEETTDHHIK 637
AHRLSTVR+AD+I G V +GTH ELL + +G Y LV LQ S+E H
Sbjct: 614 AHRLSTVRSADVIIGFEHGTAVERGTHEELL-ERKGVYFMLVTLQ-----SQEDNTH--- 664
Query: 638 RELSAKSFRQLSQRKSLQRSISRGS-------SIGNSSRHSFS-VSSVLPTGI----NAI 685
+E K + ++ + +R+ SRGS SI S+ S +S P I ++
Sbjct: 665 KETGIKG-KDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLSHEPPLAIGDHKSSY 723
Query: 686 DPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTF 745
+ +N E+ + P+ R+ N E P +L G A NG + PI+ +L S ++KTF
Sbjct: 724 EDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTF 783
Query: 746 YEPFDEMKKDSKF-WAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSME 804
E ++ + + F++LG SL Q Y F+ +G L +R+R F+ ++ +
Sbjct: 784 SLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQD 843
Query: 805 VGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALI 864
+GWFD+ +N+ G + RL+ DA+ V+ G +G++V + ++IAF+ +W+L+L+
Sbjct: 844 IGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLV 903
Query: 865 ILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELY 924
I V P + L+G VQ K + GF++ K + E+A Q+ N+A+ +IR VA E + ++ +
Sbjct: 904 ISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAF 963
Query: 925 RKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFA 984
+ E KT IR+ + G + S + F + ++ G L+ FS VFRV +
Sbjct: 964 EVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSS 1023
Query: 985 LTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRHL 1044
+ M+ + ++ S+ P +KAK + A F+++D+K ID +G D+ +G+I+
Sbjct: 1024 IAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDC 1083
Query: 1045 SFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIE 1104
F YPSRPDIQ+ L++++ G+T+A VG SG GKST I LL+RFYDPD G + +DG +
Sbjct: 1084 KFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHD 1143
Query: 1105 IRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNATEAE-IIAAAELANADRFISG 1163
+++ +++LR +G+VSQEPVLF+ +I NI YG E IAAA+ A F+
Sbjct: 1144 SKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMS 1203
Query: 1164 LQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALDK 1223
L + Y+T VG +G+QLS G+KQR+AIARAI++ PKILLLDEATSALD ESE+ VQ ALDK
Sbjct: 1204 LPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDK 1263
Query: 1224 VMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLIN 1265
RT +V+AHRLST++N+D+IAV+ GV++EKG H+ L++
Sbjct: 1264 AREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMD 1305
Score = 363 bits (932), Expect = 2e-99
Identities = 209/591 (35%), Positives = 340/591 (57%), Gaps = 7/591 (1%)
Query: 32 EKDITKEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSN 91
+ D+ E+ E P ++ + + ++ ++VG + A NG PI ++L Q++ +F +
Sbjct: 728 DNDVLVEEVEPAPVRRILKY-NISEWPYILVGALCAAINGAVTPIYSLLFSQILKTF--S 784
Query: 92 QTNTEDIVDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDV 151
+ E ++ + L +V L S FLQ + +GE R+R K +LRQD+
Sbjct: 785 LVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDI 844
Query: 152 TFFDK-ETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVL 210
+FD + N G + R++ D +Q A G +VG + +IAF W L++V+
Sbjct: 845 GWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVI 904
Query: 211 MSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYS 270
P L +SGA ++ AS+ + KA + + + +IRTVA E + + +
Sbjct: 905 SVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFE 964
Query: 271 KHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGTVINVIMVV 330
L YK+ + + + G+ + FL + A +G +++ + N V V+ +
Sbjct: 965 VELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSI 1024
Query: 331 LTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVY 390
++ ++G+ S ++A + +A + F+ + R+P ID Y G+ ++ QG+I+ +
Sbjct: 1025 AMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCK 1084
Query: 391 FSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINM 450
F+YP+RP+ + NG S+ + G T A VG SG GKST I L+ERFYDP G V+IDG +
Sbjct: 1085 FTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDS 1144
Query: 451 KEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGA--TIEEIRSASELANAAKFIDKL 508
K+ V+++R IG+VSQEPVLF SI DNI YG + ++E +A++ A F+ L
Sbjct: 1145 KKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSL 1204
Query: 509 PQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRI 568
P+ +T VG GSQLS G+KQRIAIARAI+++P+ILLLDEATSALD +SE+ VQ LD+
Sbjct: 1205 PEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKA 1264
Query: 569 MVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLV 619
RT +V+AHRLST++N+D+IA++ +G ++ KGTH +L+ D +GAY +LV
Sbjct: 1265 REGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLM-DQKGAYYKLV 1314
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein A)
Length = 1321
Score = 843 bits (2178), Expect = 0.0
Identities = 472/1275 (37%), Positives = 746/1275 (58%), Gaps = 44/1275 (3%)
Query: 26 NATTNGEKDITKEKQETV----PFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLL 81
N +NGE IT++ +E V +L+ + + + LL+ +GT+ A+ G GLP+M++L
Sbjct: 39 NIDSNGEIKITRDAKEEVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQ 98
Query: 82 GQMIHSF-----------------GSNQTNTEDIVDQVTKVSLKYVYLAVGSGVAAFLQV 124
G++ +F G N T T D V V Y + VG A + V
Sbjct: 99 GKVSQAFINEQIVINNNGSTFLPTGQNYTKT-DFEHDVMNVVWSYAAMTVGMWAAGQITV 157
Query: 125 SCWMVTGERQAARIRGLYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGK 184
+C++ E+ R+R ++K+ILRQ++++FD ++G + ++ + +++ G+K+G
Sbjct: 158 TCYLYVAEQMNNRLRREFVKSILRQEISWFDTN-HSGTLATKLFDNLERVKEGTGDKIGM 216
Query: 185 FLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAH 244
Q ++ F+ GF++AFT W LT+V+++ P+ + G A+A + A + YAKA
Sbjct: 217 AFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGK 276
Query: 245 VVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYAL 304
VVE+TI SIRTV S G + + YS + + K+GV +G G+ G F+ +AL
Sbjct: 277 VVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFAL 336
Query: 305 AVWFGAKMVMEKGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRR 364
A + G V + N G ++ V+ SM+LG A L+ + AA ++E + R+
Sbjct: 337 AFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRK 396
Query: 365 PEIDAYDPNGKILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSG 424
P ID+ G+ I+G+I ++ V+F+YP+RP+ I G +L + +G T ALVG SG G
Sbjct: 397 PVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCG 456
Query: 425 KSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGK 484
KSTIISL+ R+YD G++ IDG+++++ + ++R + +VSQEP LF +I++NIS GK
Sbjct: 457 KSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGK 516
Query: 485 DGATIEEIRSASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRIL 544
+G T EE+ +A ++ANA KFI LP G +T+VGD G+QLSGGQKQRIAIARA+++NP+IL
Sbjct: 517 EGITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKIL 576
Query: 545 LLDEATSALDAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTH 604
LLDEATSALDA+SE +VQ+ LD+ RTT+++AHRLST+RNAD+I G++V G H
Sbjct: 577 LLDEATSALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDH 636
Query: 605 TELLKDPEGAYSQLVRLQEINKESEETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSI 664
L+ +G Y LV Q + + RE S RQ S+ + L R S I
Sbjct: 637 RALMAQ-QGLYYDLVTAQTFTDAVDSAAEGKFSRENSVA--RQTSEHEGLSRQASEMDDI 693
Query: 665 GNSSRHSFSVSSVLPTGINAIDPGLENLP-----------TKEKGQEVPLSRLATLNKPE 713
N R S ++ S+ T ID E + + Q+ L + +P
Sbjct: 694 MNRVRSS-TIGSI--TNGPVIDEKEERIGKDALSRLKQELEENNAQKTNLFEILYHARPH 750
Query: 714 IPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYEPFDEMKKDSKFWAVMFMLLGFASLLV 773
L G A G I+P + + +S + F + FWA+MF++L A +
Sbjct: 751 ALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFAGNPADFLSQGHFWALMFLVLAAAQGIC 810
Query: 774 VTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIV 833
++F +A L + +R F V+S +G+FD P+N+SG + RL+ D ++RT +
Sbjct: 811 SFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAI 870
Query: 834 GDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMM 893
++ L + ++G+ +AF WQ+AL+I+ ++P++ Y++ + G + +
Sbjct: 871 DFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASE 930
Query: 894 YEEASQVANDAVGSIRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLL 953
+ ++ ++A +A+ ++R V + E+ E + +K ++P K I++ I G +G + +L
Sbjct: 931 FADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVL 990
Query: 954 FCVYALSFYAGARLVESGHTKFSD--VFRVFFALTMATVGISQSSSFAPDSSKAKSATAS 1011
+ + ++ G L+ + V RV +A+T++T + ++S+ P+ +KA A
Sbjct: 991 YLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGI 1050
Query: 1012 IFRMIDKKSKIDPSDESGTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVA 1071
IF M+ K SKID +G + G++ +++ F YP RP+I+I + L+ ++ G+T+A
Sbjct: 1051 IFGMLRKISKIDSLSLAGEK-KKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLA 1109
Query: 1072 LVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTI 1131
LVG SG GKSTV+ALL+RFYD GEI +DG EI+ L + R Q+ +VSQEP LF+ +I
Sbjct: 1110 LVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSI 1169
Query: 1132 RSNIAYG-KGGNATEAEIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIA 1190
NI YG + T A++ AA LAN FI+ L +G++T VG+RGTQLSGGQKQR+AIA
Sbjct: 1170 AENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIA 1229
Query: 1191 RAIIKSPKILLLDEATSALDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVK 1250
RA++++PKILLLDEATSALD ESE+VVQ+ALD+ RT +V+AHRL+TV NAD IAVV
Sbjct: 1230 RALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVS 1289
Query: 1251 NGVIVEKGRHETLIN 1265
NG I+EKG H L++
Sbjct: 1290 NGTIIEKGTHTQLMS 1304
Score = 333 bits (853), Expect = 2e-90
Identities = 198/575 (34%), Positives = 312/575 (53%), Gaps = 10/575 (1%)
Query: 58 LLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTEDIVDQVTKVSLKYVYLAVGSG 117
L + +G A G P +V ++ F N D + Q +L ++ LA G
Sbjct: 752 LSLFIGMSTATIGGFIYPTYSVFFTSFMNVFAGNPA---DFLSQGHFWALMFLVLAAAQG 808
Query: 118 VAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETN-TGEVIGRMSGDTVLIQD 176
+ +FL + E +R + +L Q + FFD N +G++ R++ D ++
Sbjct: 809 ICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRT 868
Query: 177 AMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQ 236
A+ + + + + V G +AF GW + +++++ LP++ K
Sbjct: 869 AIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSA 928
Query: 237 TAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMF 296
+ +A + + + I ++RTV + E N+ + L +K + E FI G+ G
Sbjct: 929 SEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASS 988
Query: 297 LMFLGYALAVWFGAKMVMEKG--YNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAA 354
+++L A G +++ V+ V+ + ++ +LG A+S +A A
Sbjct: 989 VLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAG 1048
Query: 355 YKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTT 414
+F +++ +ID+ G+ + + G++ K V F+YP RPE I G S + G T
Sbjct: 1049 GIIFGMLRKISKIDSLSLAGE-KKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQT 1107
Query: 415 TALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFAS 474
ALVG SG GKST+++L+ERFYD GE+ IDG +K R +I +VSQEP LF
Sbjct: 1108 LALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDC 1167
Query: 475 SIKDNISYGKD--GATIEEIRSASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIA 532
SI +NI YG D T+ ++ A+ LAN FI +LP+G +T VGD G+QLSGGQKQRIA
Sbjct: 1168 SIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIA 1227
Query: 533 IARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAI 592
IARA+++NP+ILLLDEATSALD +SE+VVQE LDR RT +V+AHRL+TV NAD IA+
Sbjct: 1228 IARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAV 1287
Query: 593 IHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINKE 627
+ G ++ KGTHT+L+ + +GAY +L + Q K+
Sbjct: 1288 VSNGTIIEKGTHTQLMSE-KGAYYKLTQKQMTEKK 1321
>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 843 bits (2178), Expect = 0.0
Identities = 482/1292 (37%), Positives = 749/1292 (57%), Gaps = 46/1292 (3%)
Query: 17 ENNRTETSTNATTNGEKDITKEKQET----VPFHKLFSFADSTDILLMIVGTIGAIGNGL 72
E N S + N +K ++K+++ + F +LF F+ TDI LM +G++ A +G+
Sbjct: 15 EENHGFESDGSYNNEKKSRLQDKKKSDSVRIGFFQLFRFSSWTDIWLMCMGSLCACIHGI 74
Query: 73 GLPIMTVLLGQMIHSF-----------------------------GSNQTNTE-----DI 98
P + ++ G M F N TN DI
Sbjct: 75 AQPGVLLIFGTMTDVFIDYDTELQELKIPGKACVNNTIVWINSSLNQNVTNGTRCGLLDI 134
Query: 99 VDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKET 158
++ + + Y + + ++Q+ W + Q ++R Y + I+R + + D +
Sbjct: 135 ESEMIRFAGYYAGIGIAVLTTGYIQICFWGIAAAHQIQKMRKSYFRKIMRMGIGWVDCNS 194
Query: 159 NTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLV 218
G++ S D I D+ +++ F+Q + + + GF++ F++ W LT+V++S PL+
Sbjct: 195 -VGKLNTPFSVDFNKINDSSADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIG 253
Query: 219 VSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYK 278
+ A + + + + AYAKA V ++ I S+RTVA+F GEK+ V Y K+LV +
Sbjct: 254 LGAAIIGLSVSKFTDYELKAYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQR 313
Query: 279 SGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKG-YNGGTVINVIMVVLTASMSL 337
G+ +G + G G L+F YALA W+G+K+V+E+G Y+ G ++ + + V+ +++L
Sbjct: 314 WGIRKGIVMGFFTGYMWCLIFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNL 373
Query: 338 GQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARP 397
G AS L AFAAGRAAA +FETI R+P ID +G LE I+GEIE V F YP+RP
Sbjct: 374 GNASPCLEAFAAGRAAASSIFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRP 433
Query: 398 EELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRW 457
E I N S+ I G TALVG SG+GKST + L+ RFY P G V ++ +++ ++W
Sbjct: 434 EVKILNNLSMVIKPGEMTALVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQW 493
Query: 458 IRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVG 517
+R +IG+V QEPVLF +I + I YG++ AT+E++ A++ ANA FI LPQ DT+VG
Sbjct: 494 LRNQIGIVEQEPVLFFHTIAEKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLVG 553
Query: 518 DHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVV 577
+ G Q+SGGQKQR+AIARA+++NP+ILLLD ATSALD +SE +VQE L + T V V
Sbjct: 554 EGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEALSKTQHGHTIVSV 613
Query: 578 AHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINK--ESEETTDHH 635
AHR +T+R AD+I G V +GT ELL + +G Y LV LQ + EE
Sbjct: 614 AHRPATIRTADVIIGCEHGAAVERGTEEELL-ERKGVYFALVTLQSQRNQGDQEENEKDA 672
Query: 636 IKRELSAKSFRQLSQRKSLQRSI-SRGSSIGNSSRHSFSVSSVLPTGINAIDPGLENLPT 694
+ ++ K+F + + + SL+ S+ R S + H ++ + D ++LP
Sbjct: 673 TEDDIPEKTFSRGNYQDSLRASLRQRSKSQLSYLAHEPPMAVEDHKSTHEEDRKDKDLPA 732
Query: 695 KEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYEP-FDEMK 753
+E + + R+ LN PE P +L G A NG + P++ L S ++ TF P +E +
Sbjct: 733 QEDIEPASVRRIMKLNAPEWPYMLLGSMGAAVNGAVTPLYAFLFSQILGTFSLPDKEEQR 792
Query: 754 KDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPEN 813
++F+ LG S Q Y F+ +G L +R+R F ++ ++GWFD+ N
Sbjct: 793 SQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRN 852
Query: 814 SSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIG 873
S G++ RL+ DA+ V+ G +G++V + +IIAF+ SW+L L I+ P +
Sbjct: 853 SPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLA 912
Query: 874 LNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYRKKCEVPMK 933
L+G +Q K + GF++ K E+A Q+ ++A+ +IR VA E K +E + + E P K
Sbjct: 913 LSGALQTKMLTGFASRDKQALEKAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYK 972
Query: 934 TGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALTMATVGIS 993
I++ + G FG S + F + S+ G L+ + FS VFRV A+ ++ +
Sbjct: 973 MAIKKANVYGLCFGFSQCITFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
Query: 994 QSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRHLSFKYPSRPD 1053
++SS+ P +KAK + A F+++D++ I+ +G D+ +G+I+ F YPSRPD
Sbjct: 1033 RASSYTPSYAKAKISAARFFQLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPD 1092
Query: 1054 IQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLKWL 1113
IQ+ L++++ +T+A VG SG GKST I LL+RFYDPD G++ +DG + R++ +++L
Sbjct: 1093 IQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFL 1152
Query: 1114 RQQMGLVSQEPVLFNDTIRSNIAYGKGGNATEAE-IIAAAELANADRFISGLQQGYDTIV 1172
R +G+VSQEPVLF +I+ NI YG E IIAAA+ A F+ L + Y+T V
Sbjct: 1153 RSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNV 1212
Query: 1173 GERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALDKVMVNRTTVV 1232
G +G+QLS G+KQR+AIARAI++ PKILLLDEATSALD ESE+ VQ ALDK RT +V
Sbjct: 1213 GSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1272
Query: 1233 VAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
+AHRLST++N+D+IAV+ G+++EKG HE L+
Sbjct: 1273 IAHRLSTIQNSDIIAVMSQGMVIEKGTHEELM 1304
Score = 373 bits (958), Expect = e-102
Identities = 208/563 (36%), Positives = 333/563 (58%), Gaps = 6/563 (1%)
Query: 60 MIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTEDIVDQVTKVSLKYVYLAVGSGVA 119
M++G++GA NG P+ L Q++ +F + + E+ Q+ + L +V L S
Sbjct: 755 MLLGSMGAAVNGAVTPLYAFLFSQILGTF--SLPDKEEQRSQINGICLLFVTLGCVSFFT 812
Query: 120 AFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETNT-GEVIGRMSGDTVLIQDAM 178
FLQ + +GE R+R + +L QD+ +FD N+ G + R++ D +Q A
Sbjct: 813 QFLQGYTFAKSGELLTKRLRKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGAT 872
Query: 179 GEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTA 238
G ++G + +IAF W LT+ ++ P L +SGA ++ AS+ + A
Sbjct: 873 GSQIGMMVNSFTNVTVAMIIAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQA 932
Query: 239 YAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLM 298
KA + + + +IRTVA E++ + + L YK + + + G+ G +
Sbjct: 933 LEKAGQITSEALSNIRTVAGIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCIT 992
Query: 299 FLGYALAVWFGAKMVMEKGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMF 358
F+ + + +G ++ +G + V VI V+ ++ +LG+ASS ++A + +A + F
Sbjct: 993 FIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFF 1052
Query: 359 ETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALV 418
+ + R+P I+ Y G+ ++ QG+I+ + F+YP+RP+ + NG S+ + T A V
Sbjct: 1053 QLLDRQPPINVYSSAGEKWDNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFV 1112
Query: 419 GQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKD 478
G SG GKST I L+ERFYDP G+V+IDG + ++ ++++R IG+VSQEPVLFA SIKD
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKD 1172
Query: 479 NISYGKDGATI--EEIRSASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARA 536
NI YG + I E I +A++ A F+ LP+ +T VG GSQLS G+KQRIAIARA
Sbjct: 1173 NIKYGDNTQEIPMERIIAAAKKAQVHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARA 1232
Query: 537 ILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRG 596
I+++P+ILLLDEATSALD +SE+ VQ LD+ RT +V+AHRLST++N+D+IA++ +G
Sbjct: 1233 IVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQG 1292
Query: 597 KMVSKGTHTELLKDPEGAYSQLV 619
++ KGTH EL+ +GAY +LV
Sbjct: 1293 MVIEKGTHEELMVQ-KGAYYKLV 1314
>PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1
Length = 1362
Score = 778 bits (2009), Expect = 0.0
Identities = 473/1284 (36%), Positives = 716/1284 (54%), Gaps = 59/1284 (4%)
Query: 33 KDITKEKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSF---- 88
K I + + ++ S+AD DI+L + GTI IG GLG+P+M+++ GQ+ +F
Sbjct: 68 KQINDTPAKLSGYPRILSYADKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAFTDLA 127
Query: 89 -GSNQTNTEDIVDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTIL 147
G ++ + VD L ++Y+A+G +++ +++ GER A RIR YL IL
Sbjct: 128 SGKGASSFQHTVDHFC---LYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDYLHAIL 184
Query: 148 RQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLT 207
Q++ +FD+ GE+ R++ DT IQD +GEKVG IATFV GFVIAF R W T
Sbjct: 185 SQNIGYFDR-LGAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFT 243
Query: 208 VVLMSTLPLLVVSGAAMAVIIGRMASKGQTAY-AKAAHVVEQTIGSIRTVASFTGEKQAV 266
++L S P + G + V +KGQ A A+++ VE+ +IR +F +
Sbjct: 244 LILSSMFPA-ICGGIGLGVPFITKNTKGQIAVVAESSTFVEEVFSNIRNAFAFGTQDILA 302
Query: 267 ANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGTVINV 326
Y+K+L+ + G+ + G+ VG F+ + Y LA W G +++ + +I
Sbjct: 303 KLYNKYLITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLLHAGDLDVSKLIGC 362
Query: 327 IMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIEL 386
VL AS SL S + +F + +AA K+F+TI R I+A+ P G +++DI+GEIEL
Sbjct: 363 FFAVLIASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIKGEIEL 422
Query: 387 KEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLID 446
K + F YP RPE L+ + FSL PSG TALVG SGSGKSTII LVERFYDP G+V +D
Sbjct: 423 KNIRFVYPTRPEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGGQVFLD 482
Query: 447 GINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYG-----KDGATIEEIR----SASE 497
G +++ V +R +I LV QEPVLFA+++ +NI+YG K + EE+ A++
Sbjct: 483 GKDLRTLNVASLRNQISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRVYDAAK 542
Query: 498 LANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKS 557
LANA FI LP+ T VG G +SGGQKQRIAIARA++ +P+ILLLDEATSALD+KS
Sbjct: 543 LANAYDFIMTLPEQFSTNVGQRGFLMSGGQKQRIAIARAVISDPKILLLDEATSALDSKS 602
Query: 558 ERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQ 617
E +VQ+ LD +RTT+V+AHRLST+RNAD I +++ GK+V +G+H ELL D GAY++
Sbjct: 603 EVLVQKALDNASRSRTTIVIAHRLSTIRNADNIVVVNAGKIVEQGSHNELL-DLNGAYAR 661
Query: 618 LVRLQEIN--KESEETTDHHIK---RELSAKSF-----------------RQLSQRKSLQ 655
LV Q+++ ++ +E + ++ RE+ SF + +L
Sbjct: 662 LVEAQKLSGGEKDQEMVEEELEDAPREIPITSFGDDDEDNDMASLEAPMMSHNTDTDTLN 721
Query: 656 RSISRGSSIGNSSRHSFSVSSVLPTGINAIDPG-LENLPTKEKGQEVPLSRLATL----- 709
++ ++ + V+S + + D G L P K K + + +L
Sbjct: 722 NKLNEKDNVVFEDKTLQHVASEIVPNLPPADVGELNEEPKKSKKSKKNNHEINSLTALWF 781
Query: 710 ------NKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYE--PFDEMKKDSKFWAV 761
EI LL G A++ G +P+ + + + F + D + K + F AV
Sbjct: 782 IHSFVRTMIEIICLLIGILASMICGAAYPVQAAVFARFLNIFTDLSSTDFLHKVNVF-AV 840
Query: 762 MFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPENSSGSVGAR 821
+++L ++ + A ++QRIR F ++ +V +FD EN+ G++
Sbjct: 841 YWLILAIVQFFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFDRSENTVGAITTS 900
Query: 822 LSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIGLNGYVQMK 881
LS S+ + G LG L +S I++ W+L L+ L P+I GY +++
Sbjct: 901 LSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVR 960
Query: 882 SMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYRKKCEVPMKTGIRQGII 941
++ Y+E++ A ++ +IR VAS E V Y P + +
Sbjct: 961 ALDQVQEKLSAAYKESAAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIASLK 1020
Query: 942 SGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALTMATVGISQSSSFAPD 1001
SG F + + F + AL+F+ G+ L+ G + F A+ Q ++ D
Sbjct: 1021 SGLFFSAAQGVTFLINALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSAD 1080
Query: 1002 SSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVK-GEIELRHLSFKYPSRPDIQIFQDL 1060
+KAK+A I + + K KID G ++S++ IE R + F YP+R I++ + L
Sbjct: 1081 VTKAKAAAGEIKYLSESKPKIDTWSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGL 1140
Query: 1061 NLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLV 1120
NLT+ G+ VA VG SG GKST I L++RFYD D+G + +DG+ +R + R+Q+ LV
Sbjct: 1141 NLTVKPGQFVAFVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNINDYRKQIALV 1200
Query: 1121 SQEPVLFNDTIRSNIAYGKGGNATEAEIIAAAELANADRFISGLQQGYDTIVGERGTQLS 1180
SQEP L+ T+R NI G + +E E+I A + AN FI GL GY+T+ G++G+ LS
Sbjct: 1201 SQEPTLYQGTVRENIVLGASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQKGSSLS 1260
Query: 1181 GGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALDKVMVNRTTVVVAHRLSTV 1240
GGQKQR+AIARA+I++PKILLLDEATSALD+ SE+VVQ+AL+ RTTV +AHRLS++
Sbjct: 1261 GGQKQRIAIARALIRNPKILLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSSI 1320
Query: 1241 KNADVIAVVKNGVIVEKGRHETLI 1264
++AD I V GVI E G H L+
Sbjct: 1321 QDADCIFVFDGGVIAEAGTHAELV 1344
Score = 352 bits (903), Expect = 4e-96
Identities = 231/658 (35%), Positives = 348/658 (52%), Gaps = 26/658 (3%)
Query: 626 KESEETTDHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSFSVSSVLPTGINAI 685
K + D+ +LS KS + S ++S + S P +
Sbjct: 7 KSTSTVKDNEHSLDLSIKSIPSNEKNFSTEKSENEASESHVVDVVKDPFEQYTPEEQEIL 66
Query: 686 DPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTF 745
+ + P K G LS +K +I + L G IG G+ P+ +++ + + F
Sbjct: 67 YKQINDTPAKLSGYPRILSYA---DKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAF 123
Query: 746 YEPFDEMKKDSKFWAVMFMLLGFASLLV-VTAQSYFFSV----AGYKLIQRIRLLCFEKV 800
+ S V L F + + V SY ++V AG ++ +RIR +
Sbjct: 124 TDLASGKGASSFQHTVDHFCLYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDYLHAI 183
Query: 801 VSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQ 860
+S +G+FD +G + R++ D ++ +G+ +GL+ +A +SG +IAF+ W+
Sbjct: 184 LSQNIGYFDRL--GAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWK 241
Query: 861 LALIILVLIPLI----GLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCA 916
LI+ + P I GL K+ KG A + E+S + +IR +F
Sbjct: 242 FTLILSSMFPAICGGIGLGVPFITKNTKGQIA----VVAESSTFVEEVFSNIRNAFAFGT 297
Query: 917 ENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFS 976
++ + +LY K + GI + I G G FF+ + VY L+F+ G RL+ +G S
Sbjct: 298 QDILAKLYNKYLITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLLHAGDLDVS 357
Query: 977 DVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVK 1036
+ FFA+ +A+ ++ S SA IF ID+ S I+ +G + +K
Sbjct: 358 KLIGCFFAVLIASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIK 417
Query: 1037 GEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSG 1096
GEIEL+++ F YP+RP++ + + +L SGK ALVG SGSGKST+I L++RFYDP G
Sbjct: 418 GEIELKNIRFVYPTRPEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGG 477
Query: 1097 EITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYG-----KGG---NATEAEI 1148
++ LDG ++R L + LR Q+ LV QEPVLF T+ NI YG KG E +
Sbjct: 478 QVFLDGKDLRTLNVASLRNQISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRV 537
Query: 1149 IAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSA 1208
AA+LANA FI L + + T VG+RG +SGGQKQR+AIARA+I PKILLLDEATSA
Sbjct: 538 YDAAKLANAYDFIMTLPEQFSTNVGQRGFLMSGGQKQRIAIARAVISDPKILLLDEATSA 597
Query: 1209 LDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLINV 1266
LD++SE +VQ ALD +RTT+V+AHRLST++NAD I VV G IVE+G H L+++
Sbjct: 598 LDSKSEVLVQKALDNASRSRTTIVIAHRLSTIRNADNIVVVNAGKIVEQGSHNELLDL 655
Score = 331 bits (848), Expect = 9e-90
Identities = 195/574 (33%), Positives = 311/574 (53%), Gaps = 6/574 (1%)
Query: 56 DILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTEDIVDQVTKVSLKYVYLAVG 115
+I+ +++G + ++ G P+ + + ++ F ++ D + +V ++ ++ LA+
Sbjct: 791 EIICLLIGILASMICGAAYPVQAAVFARFLNIF--TDLSSTDFLHKVNVFAVYWLILAIV 848
Query: 116 SGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETNT-GEVIGRMSGDTVLI 174
A + E RIR +T+LRQDV FFD+ NT G + +S +
Sbjct: 849 QFFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQDVEFFDRSENTVGAITTSLSTKIQSL 908
Query: 175 QDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASK 234
+ G +G F Q++ + +++ GW L +V +ST P+++ +G + ++ K
Sbjct: 909 EGLSGPTLGTFFQILTNIISVTILSLATGWKLGLVTLSTSPVIITAGYYRVRALDQVQEK 968
Query: 235 GQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTF 294
AY ++A ++ +IRTVAS E+ A Y L+ + SG+
Sbjct: 969 LSAAYKESAAFACESTSAIRTVASLNREENVFAEYCDSLIKPGRESAIASLKSGLFFSAA 1028
Query: 295 MFLMFLGYALAVWFGAKMVMEKGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAA 354
+ FL AL W+G+ ++ + YN + ++ GQ + +AAA
Sbjct: 1029 QGVTFLINALTFWYGSTLMRKGEYNIVQFYTCFIAIVFGIQQAGQFFGYSADVTKAKAAA 1088
Query: 355 YKMFETIKRRPEIDAYDPNGKILEDIQGE-IELKEVYFSYPARPEELIFNGFSLHIPSGT 413
++ + +P+ID + GK +E +Q IE ++V FSYP R + G +L + G
Sbjct: 1089 GEIKYLSESKPKIDTWSTEGKKVESLQSAAIEFRQVEFSYPTRRHIKVLRGLNLTVKPGQ 1148
Query: 414 TTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFA 473
A VG SG GKST I L+ERFYD G VL+DG+N++++ + R +I LVSQEP L+
Sbjct: 1149 FVAFVGSSGCGKSTTIGLIERFYDCDNGAVLVDGVNVRDYNINDYRKQIALVSQEPTLYQ 1208
Query: 474 SSIKDNISYGKD-GATIEEIRSASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIA 532
++++NI G + EE+ A + AN +FI LP G +T+ G GS LSGGQKQRIA
Sbjct: 1209 GTVRENIVLGASKDVSEEEMIEACKKANIHEFILGLPNGYNTLCGQKGSSLSGGQKQRIA 1268
Query: 533 IARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAI 592
IARA+++NP+ILLLDEATSALD+ SE+VVQE L+ RTTV +AHRLS++++AD I +
Sbjct: 1269 IARALIRNPKILLLDEATSALDSHSEKVVQEALNAASQGRTTVAIAHRLSSIQDADCIFV 1328
Query: 593 IHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINK 626
G + GTH EL+K G Y +LV Q +NK
Sbjct: 1329 FDGGVIAEAGTHAELVKQ-RGRYYELVVEQGLNK 1361
>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
(P-glycoprotein 65)
Length = 1302
Score = 770 bits (1988), Expect = 0.0
Identities = 473/1304 (36%), Positives = 733/1304 (55%), Gaps = 77/1304 (5%)
Query: 20 RTETSTNATTNGEKDITK-----EKQETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGL 74
R E ST+++ ++ E E + F KLF F+ +I + G I L L
Sbjct: 3 RDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTL 62
Query: 75 PIMTVLLGQM----------------IHS---FGSNQT--------NTEDIVDQVTKVSL 107
P + ++ + +H+ FG +T N E + D +
Sbjct: 63 PAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGI 122
Query: 108 KYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETNTGEVIGRM 167
+V ++ V + + RQ R+R +++RQD+ + D + M
Sbjct: 123 LLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQN-FTQSM 181
Query: 168 SGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVI 227
D I+D + EKVG F+ L+ F+ I+F+ GW LT+ + S +PL+++ +A
Sbjct: 182 VDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKF 241
Query: 228 IGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKSGVFEGFIS 287
G++ ++ Q +YA A ++ E+ + SIRTV SF GEK V Y LV K+ ++G S
Sbjct: 242 QGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFS 301
Query: 288 GVGVGTFMFLMFLGYALAVWFGAKMVME------KGYNGGTVINVIMVVLTASMSLGQAS 341
G+ +++L A A W+G ++++ K Y ++ ++ + ++ + +
Sbjct: 302 GLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTA 361
Query: 342 SGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILE-DIQGEIELKEVYFSYPARPEEL 400
L +FA R A +F+ I +ID +GK+L ++G++E ++V+F YP+RPE +
Sbjct: 362 PFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVI 421
Query: 401 IFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIRG 460
+ G ++ I +G T ALVG SG GKST + L++RFYDP G VL+D ++++++ ++W+R
Sbjct: 422 VHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRS 481
Query: 461 KIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVGDHG 520
I +V QEPVLF +I NISYGK GAT +EI +A+ A A +FI LP+ +M+G+ G
Sbjct: 482 NIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERG 541
Query: 521 SQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNRTTVVVAHR 580
SQLSGGQKQRIAIARA+++NP+ILLLDEATSALD +SE+ VQ+ LD RTT+VV+HR
Sbjct: 542 SQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHR 601
Query: 581 LSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINKESEETTDHHIKREL 640
LS +R AD I IH GK++ +G+H +L+ EGAY +VR +IN E +++E
Sbjct: 602 LSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDE------VEKED 654
Query: 641 SAKSFRQLSQ---RKSLQRS-ISRGSSIGNSSRHSFSVSSVLPTGINAIDPGLENLPTKE 696
S + +Q S KS + S ++ NS + + L NA P ++
Sbjct: 655 SIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQS---AEAPPEK 711
Query: 697 KGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTFYE--PFDEMKK 754
SR+ L K E L+ G +A+ G ++P F ++ E P D +++
Sbjct: 712 PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRR 771
Query: 755 DSKF-WAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPEN 813
+ WA + L F + LV Q+Y F+ AG L R+R + F +V+ EVGWFD+ N
Sbjct: 772 TAVLSWACLG--LAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENN 829
Query: 814 SSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIG 873
S G++ ARLS +A ++ +G L ++ L+ +S + +A +W+LAL+ L P+I
Sbjct: 830 SVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV 889
Query: 874 LNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYR---KKCEV 930
+ ++ K M K + EEA ++A +++ +IR VA E V+ Y ++ EV
Sbjct: 890 GSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEV 949
Query: 931 PMKTGIR-QGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALTMAT 989
++ +R +G+++ + +FF YA++ G LV G F D+ +V L +
Sbjct: 950 LIRQKLRWRGVLNSTMQASAFF----AYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGS 1005
Query: 990 VGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIEL------RH 1043
+ ++QS +F P S A A +F+++D+K KI GT +++ ++ L R
Sbjct: 1006 MMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGTIKNTLAKQLNLFEGVRYRG 1063
Query: 1044 LSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGI 1103
+ F+YP+RPD +I L+L + G+TVALVG SG GKST + LLQR+YDPD G I +D
Sbjct: 1064 IQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHD 1123
Query: 1104 EIR-QLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNATE-AEIIAAAELANADRFI 1161
+I+ L L +R ++G+VSQEP LF +I NIAYG + EIIAAA+ ANA FI
Sbjct: 1124 DIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFI 1183
Query: 1162 SGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDAL 1221
L GYDT +G RGTQLSGGQKQR+AIARA++++PKILLLDEATSALD +SE++VQ AL
Sbjct: 1184 ISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQAL 1243
Query: 1222 DKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLIN 1265
D RT +V+AHRLSTV+NADVI V++NG +VE+G H LI+
Sbjct: 1244 DTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS 1287
>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
(P-glycoprotein 49)
Length = 1302
Score = 754 bits (1946), Expect = 0.0
Identities = 453/1243 (36%), Positives = 712/1243 (56%), Gaps = 38/1243 (3%)
Query: 43 VPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTEDIVDQV 102
+P+ + + + T +L+ +G LP+ GQ + + S + N + I+D
Sbjct: 60 IPYFMII-YGEFTSLLVDRTVGVGTSSPAFALPMFGG--GQQLTN-ASKEENNQAIIDDA 115
Query: 103 TKVSLKYVYLAVGSGVAAFLQVSCWMVTGER----QAARIRGLYLKTILRQDVTFFDKET 158
T + + VGS VA FL ++ + R Q RIR L+L+ +LRQD+ ++D +
Sbjct: 116 TAFGIGSL---VGS-VAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSS 171
Query: 159 NTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLV 218
+ +M+ D +++ +GEK+ + LI TFV G V AF GW LT+V++S +P ++
Sbjct: 172 GSN-FASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFII 230
Query: 219 VSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYK 278
+ + +A + G +A K +Y+ AA+VVE+ IRTV +F+G+++ + K L+
Sbjct: 231 AATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAEN 290
Query: 279 SGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKG------YNGGTVINVIMVVLT 332
+G +G SG+G +++L ALA+W+G +++++ Y ++ V+ V+
Sbjct: 291 TGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIM 350
Query: 333 ASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFS 392
+ +LG AS + A A AA +F I R ++D D G E+ G I + + F
Sbjct: 351 GAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFR 410
Query: 393 YPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKE 452
YPARP+ I G ++ + G T A VG SG GKST+I L++RFYDP+AG V +DG +++
Sbjct: 411 YPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRT 470
Query: 453 FQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGL 512
V W+R +IG+V QEPVLFA++I +NI YG+ AT +I A+ AN FI +LP+G
Sbjct: 471 LNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGY 530
Query: 513 DTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVNR 572
DT VG+ G+Q+SGGQKQRIAIARA+++ P++LLLDEATSALD SE+ VQ L+
Sbjct: 531 DTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGP 590
Query: 573 TTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEGAYSQLVRLQEINKESEETT 632
TT+VVAHRLST+ NAD I + G + +GTH EL+ + G Y +LV + + KE+ E
Sbjct: 591 TTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELM-ERRGLYCELVSITQ-RKEATEAD 648
Query: 633 DHHIKRELSAKSFRQLSQRKSLQRSISRGS-------SIGNSSRHSFSVSSVLPTGINAI 685
+ + KS + LS ++ + G+S F S T
Sbjct: 649 EGAVAGRPLQKS-QNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRAS----TRRKRR 703
Query: 686 DPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSSMIKTF 745
+ KE +V ++L LN PE ++ G A++ +G FP++G+
Sbjct: 704 SQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGIL 763
Query: 746 YEPFDEMKKDSKFW-AVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEKVVSME 804
+ D++ + +++F+ +G + L Q+Y F+ AG K+ R+R F ++ +
Sbjct: 764 SDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQD 823
Query: 805 VGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALI 864
+ +FD+ NS G++ +RL++D ++V+ G +G ++ +A + G+++ FV SWQ L+
Sbjct: 824 IAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLL 883
Query: 865 ILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELY 924
LV +PL+ L+ Y++ + + + AK EEASQVA +A+ +IR V C E +V++ Y
Sbjct: 884 TLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQY 943
Query: 925 RKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFA 984
++ + R+ G F + F Y +S Y G LV + D+ +V A
Sbjct: 944 VQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEA 1003
Query: 985 LTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKS-KIDPSDESGTTLDSVKGEIELRH 1043
L + + Q+ ++AP+ + A + + + + S + +P T++ +G+I +
Sbjct: 1004 LIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYEN 1063
Query: 1044 LSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGI 1103
+ F+YP+R I Q LNLTI TVALVG SGSGKST + LL R+YDP SG + L G+
Sbjct: 1064 VGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGV 1123
Query: 1104 EIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKG--GNATEAEIIAAAELANADRFI 1161
+ L LR ++GLVSQEPVLF+ TI NIAYG + + EII AA+ +N FI
Sbjct: 1124 PSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFI 1183
Query: 1162 SGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDAL 1221
S L QGYDT +G+ +QLSGGQKQR+AIARA++++PKIL+LDEATSALD ESE+VVQ AL
Sbjct: 1184 SALPQGYDTRLGKT-SQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQAL 1242
Query: 1222 DKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
D+ RT + +AHRL+TV+NAD+I V+K GV+VE G H+ L+
Sbjct: 1243 DEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
>MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprotein C)
Length = 1268
Score = 735 bits (1898), Expect = 0.0
Identities = 440/1260 (34%), Positives = 692/1260 (54%), Gaps = 38/1260 (3%)
Query: 30 NGEKDITKEKQETVP---------FHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVL 80
N E DIT K P F +F AD D +L G I + NG +P +++
Sbjct: 7 NPEDDITLGKFTPKPSPQDSYQGNFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLI 66
Query: 81 LGQMIHSFGSNQTNTED-------IVDQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGER 133
+ ++ ++ ++ ++ L+Y YL V + ++ SC ER
Sbjct: 67 FEGIANALMEGESQYQNGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCER 126
Query: 134 QAARIRGLYLKTILRQDVTFFDKETNTGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFV 193
+ IR YLK++LRQD +FD ET G + +MS I+D +G+KVG + +ATF+
Sbjct: 127 RLHCIRKKYLKSVLRQDAKWFD-ETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFI 185
Query: 194 GGFVIAFTRGWLLTVVLMSTLPLLVVSGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSI 253
G I F W LT+V+M T+PL + S A + R +AY+ A + + I I
Sbjct: 186 SGVSIGFYMCWQLTLVMMITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGI 245
Query: 254 RTVASFTGEKQAVANYSKHLVDGYKSGVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMV 313
RTV +F + + Y+ L + + G+ + I + + LMF A+A W+GA +
Sbjct: 246 RTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLA 305
Query: 314 MEKGYNGGTVINVIMVVLTASMSLGQASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPN 373
+ G V V VL + LG+A+ L A R A + +F+ I PEI
Sbjct: 306 AAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSE 365
Query: 374 GKILEDIQGEIELKEVYFSYPARPEELIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVE 433
GKI E IQG++ + F+YP RPE I G S + G T ALVG SG GKST I L+
Sbjct: 366 GKIPEKIQGKLTFDGIEFTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLM 425
Query: 434 RFYDPQAGEVLIDGINMKEFQVRWIRGKIGLVSQEPVLFASSIKDNISYGKDGATIEEIR 493
RFY+ AG + +DGI ++E+ +RW+R IG+V QEP++F +++ +NI G T ++I
Sbjct: 426 RFYNQCAGMIKLDGIPIQEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIE 485
Query: 494 SASELANAAKFIDKLPQGLDTMVGDHGSQLSGGQKQRIAIARAILKNPRILLLDEATSAL 553
A ++ANA +FI KL DT++G QLSGGQKQR+AIARAI++ P+ILLLDEATSAL
Sbjct: 486 EACKMANAHEFICKLSDRYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSAL 545
Query: 554 DAKSERVVQETLDRIMVNRTTVVVAHRLSTVRNADMIAIIHRGKMVSKGTHTELLKDPEG 613
D +SER+VQ LD+ RTT+ +AHRLST+RNA I + +G + +GTH EL+ +G
Sbjct: 546 DTESERMVQTALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDG 605
Query: 614 AYSQLVRLQEINKESEETTDHHIKRELSAKSFRQLS----QRKSLQRSISRGSSIGNSSR 669
Y+ +V+ QEI + E+TT + E + +SF + S + + LQ+S++R S+ +
Sbjct: 606 IYASMVKAQEIERAKEDTTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDST--RLRQ 663
Query: 670 HSFSVSSVLPTGINAIDPGLENLPTKEKGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGV 729
S ++ +P I+ E + +E E L + PE+ ++ + G
Sbjct: 664 SMISTTTQVPEW--EIENAREEM-IEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGF 720
Query: 730 IFPIFGILTSSMIKTFYEPFDEMKKDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLI 789
+P F I+ + K D++ + ++ F+LL F + AG +
Sbjct: 721 TWPAFSIVYGQLFKILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMS 780
Query: 790 QRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALS 849
R+R+ F ++ + +FD+ ++ GS+ +RL+ DA +V+ + L ++ + +
Sbjct: 781 GRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFC 840
Query: 850 GLIIAFVASWQLALI-----ILVLIPLIGLNGYVQMKSMKGFSADAKMMYEEASQVANDA 904
G+ +AF W +A I +L+++ + Y++ + + + EAS++ ++
Sbjct: 841 GVGVAFYYGWNMAPIGLATALLLVVVQSSVAQYLKFRGQRDMDSAI-----EASRLVTES 895
Query: 905 VGSIRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAG 964
+ + + V + + + + + + P + I +G+ F ++ + +A+++ G
Sbjct: 896 ISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFG 955
Query: 965 ARLVESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDP 1024
L+ + + VF+V AL MA++ + ++S+ P+ +A+ + +F MI +KS ID
Sbjct: 956 LWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDN 1015
Query: 1025 SDESGTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVI 1084
+G T ++KG I +R + F YP+R + N++ + G+TVALVG SG GKST I
Sbjct: 1016 RGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTI 1074
Query: 1085 ALLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNAT 1144
L++R+YD G + +D +IR L +K LR + LV QEP LFN TIR NI YG N T
Sbjct: 1075 QLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGL-ENIT 1133
Query: 1145 EAEIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDE 1204
+ ++ AA LAN F+ GL GYDT VG G +LSGGQKQRVAIARAI++ PKILLLDE
Sbjct: 1134 QDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDE 1193
Query: 1205 ATSALDAESERVVQDALDKVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETLI 1264
ATSALD ESE++VQ+ALDK + RT VV+AHRLST++NAD I V +NG +E+G H+TL+
Sbjct: 1194 ATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLL 1253
Score = 340 bits (872), Expect = 1e-92
Identities = 195/514 (37%), Positives = 298/514 (57%), Gaps = 13/514 (2%)
Query: 757 KFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLLCFEK-----VVSMEVGWFDEP 811
K + + + LG A L SYF + Y L +R RL C K V+ + WFDE
Sbjct: 96 KMFCLRYFYLGVALFLC----SYFANSCLYTLCER-RLHCIRKKYLKSVLRQDAKWFDE- 149
Query: 812 ENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPL 871
+ G + ++S+ ++ +GD +G+LV +A +SG+ I F WQL L++++ +PL
Sbjct: 150 -TTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPL 208
Query: 872 IGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVGSIRIVASFCAENKVMELYRKKCEVP 931
+ Y+ K + + + Y A +AN+ + IR V +F A+ + Y +
Sbjct: 209 QLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEA 268
Query: 932 MKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGARLVESGHTKFSDVFRVFFALTMATVG 991
+ GIR+ II L+F A++F+ GA L +G VF VF+A+ + T
Sbjct: 269 RRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRR 328
Query: 992 ISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSDESGTTLDSVKGEIELRHLSFKYPSR 1051
+ +++ + A+ A IF++ID + +I + G + ++G++ + F YP+R
Sbjct: 329 LGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTR 388
Query: 1052 PDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLK 1111
P+++I + ++ ++ G+TVALVG SG GKST I LL RFY+ +G I LDGI I++ ++
Sbjct: 389 PELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIR 448
Query: 1112 WLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNATEAEIIAAAELANADRFISGLQQGYDTI 1171
WLR +G+V QEP++F T+ NI G T+ +I A ++ANA FI L YDT+
Sbjct: 449 WLRSTIGIVQQEPIIFVATVAENIRMGDV-LITDQDIEEACKMANAHEFICKLSDRYDTV 507
Query: 1172 VGERGTQLSGGQKQRVAIARAIIKSPKILLLDEATSALDAESERVVQDALDKVMVNRTTV 1231
+G QLSGGQKQRVAIARAI++ P+ILLLDEATSALD ESER+VQ ALDK RTT+
Sbjct: 508 IGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTL 567
Query: 1232 VVAHRLSTVKNADVIAVVKNGVIVEKGRHETLIN 1265
+AHRLST++NA I V G+I E+G H+ LI+
Sbjct: 568 CIAHRLSTIRNASKILVFDQGLIAERGTHDELIS 601
>MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1280
Score = 667 bits (1722), Expect = 0.0
Identities = 415/1261 (32%), Positives = 682/1261 (53%), Gaps = 86/1261 (6%)
Query: 40 QETVPFHKLFSFADSTDILLMIVGTIGAIGNGLGLPIMTVLLGQMIHSFGSNQTNTEDIV 99
+ETV ++F +AD+TD +LMI GT A+ G G+P+ + + G++ S + E+
Sbjct: 52 RETVGPIEIFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDLMSGVGSAEE-- 109
Query: 100 DQVTKVSLKYVYLAVGSGVAAFLQVSCWMVTGERQAARIRGLYLKTILRQDVTFFDKETN 159
+ K SL VY+ + +A V CW V RQ ARIR L+ + +LRQD+ + D E +
Sbjct: 110 -KAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLLFFRAVLRQDIGWHD-EHS 167
Query: 160 TGEVIGRMSGDTVLIQDAMGEKVGKFLQLIATFVGGFVIAFTRGWLLTVVLMSTLPLLVV 219
G + RM+GDT +IQ+ + +K+ + + + V G++ F W LT++++ +P ++V
Sbjct: 168 PGALTARMTGDTRVIQNGINDKLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIV 227
Query: 220 SGAAMAVIIGRMASKGQTAYAKAAHVVEQTIGSIRTVASFTGEKQAVANYSKHLVDGYKS 279
A + I+ ++ + +AKA + + + +IRTV +F E + ++K ++
Sbjct: 228 MAAIIGSIVSKITESSRKYFAKAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGR 287
Query: 280 GVFEGFISGVGVGTFMFLMFLGYALAVWFGAKMVMEKGYNGGTVINVIMVVLTASMSLGQ 339
G+ + S + M LM++ Y +A +FG+ +V + +I+ + VL S LG
Sbjct: 288 GIRKELASNLSAAVIMALMYVSYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGF 347
Query: 340 ASSGLSAFAAGRAAAYKMFETIKRRPEIDAYDPNGKILEDIQGEIELKEVYFSYPARPEE 399
+ +AF RAAAY++F+ I R P +D D G + + IE + V F+YP RP
Sbjct: 348 VAPSRTAFTESRAAAYEIFKAIDRVPPVDI-DAGGVPVPGFKESIEFRNVRFAYPTRPGM 406
Query: 400 LIFNGFSLHIPSGTTTALVGQSGSGKSTIISLVERFYDPQAGEVLIDGINMKEFQVRWIR 459
++F SL I G A G SG GKS++I L++RFYDP G VL+DG+ M+E +R R
Sbjct: 407 ILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWR 466
Query: 460 GKIGLVSQEPVLFASSIKDNISYGKDGATIEEIRSASELANAAKFIDKLPQGLDTMVGDH 519
+IG+VSQEP LFA ++ +N+ GK AT EE+ A AN I LP DT VG
Sbjct: 467 DQIGIVSQEPNLFAGTMMENVRMGKPNATDEEVVEACRQANIHDTIMALPDRYDTPVGPV 526
Query: 520 GSQLSGGQKQRIAIARAILKNPRILLLDEATSALDAKSERVVQETLDRIMVN--RTTVVV 577
GS LSGGQKQRIAIARA++K P ILLLDEATSALD KSE VQ LD+++ T VV+
Sbjct: 527 GSLLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQAALDQLIQRGGTTVVVI 586
Query: 578 AHRLSTVRNADMIAII-HRG----KMVSKGTHTELLKDPEGAYSQLVRLQEINKESEETT 632
AHRL+T+R+ D I + H G ++ GT ELL + +G ++ + ++Q +
Sbjct: 587 AHRLATIRDMDRIYYVKHDGAEGSRITESGTFDELL-ELDGEFAAVAKMQGV-------- 637
Query: 633 DHHIKRELSAKSFRQLSQRKSLQRSISRGSSIGNSSRHSFSVSSVLPTG-INAIDPGL-- 689
L G+S+ ++ + S + +L + +D +
Sbjct: 638 ---------------------LAGDAKSGASVRDAKKASGHLGVILDEADLAQLDEDVPR 676
Query: 690 ---ENLPTKE------KGQEVPLSRLATLNKPEIPVLLFGCFAAIGNGVIFPIFGILTSS 740
+N+P E K +V RL +NK + + G +++ G P I+
Sbjct: 677 TARQNVPIDELAKWEVKHAKVGFLRLMRMNKDKAWAVALGILSSVVIGSARPASSIVMGH 736
Query: 741 MIKTFYE-----PFDEMKKDSKFWAVMFMLLGFASLLVVTAQSYFFSVAGYKLIQRIRLL 795
M++ E + ++ + +A +F++ A+ F+ AG L +IR+L
Sbjct: 737 MLRVLGEYSATKDVEALRSGTNLYAPLFIVFAVANFSGWILHG-FYGYAGEHLTTKIRVL 795
Query: 796 CFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGDALGLLVMNLAAALSGLIIAF 855
F +++ ++ +FD P +G++ LS D +V + G ++GL V + SGL++ F
Sbjct: 796 LFRQIMRQDINFFDIPGRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTMCIIASGLVVGF 855
Query: 856 VASWQLALIILVLIPL---------IGLNGYVQMKSMKGFSADAKMMYEEASQVANDAVG 906
+ W+LAL+ L +PL + +NGY KS +G + D + +A+
Sbjct: 856 IYQWKLALVALACMPLMIGCSLTRRLMINGYT--KSREGDTDDT---------IVTEALS 904
Query: 907 SIRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFCVYALSFYAGAR 966
++R V S + +E ++ +R+GII+G +G++ F+ + VYAL F+ G++
Sbjct: 905 NVRTVTSLNMKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFWYGSK 964
Query: 967 LVESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRMIDKKSKIDPSD 1026
L++ G +F DV ++ ++ +FA + A+++ +F +ID+ +D
Sbjct: 965 LIDKGEAEFKDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDRVPDVDI-- 1022
Query: 1027 ESGTTLDSVKG-EIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGESGSGKSTVIA 1085
E D +G +IE R++ F Y +RP + +N+ + L+G++G GKSTVI
Sbjct: 1023 EQAGNKDLGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGKSTVIQ 1082
Query: 1086 LLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNIAYGKGGNATE 1145
+L RFY+ SG I+++G ++ L + R+ + +V QEP LF+ T+R NI Y + G AT+
Sbjct: 1083 MLARFYERRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYAREG-ATD 1141
Query: 1146 AEIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIKSPKILLLDEA 1205
E+ AA LA+ I GYDT VG +G LSGGQKQR+AIAR +++ P++LLLDEA
Sbjct: 1142 EEVEEAARLAHIHHEIIKWTDGYDTEVGYKGRALSGGQKQRIAIARGLLRRPRLLLLDEA 1201
Query: 1206 TSALDAESERVVQDALD--KVMVNRTTVVVAHRLSTVKNADVIAVVKNGVIVEKGRHETL 1263
TSALD+ +E VQ+ ++ + TTV +AHRL+T+++ D I ++ +G I+E+G HE L
Sbjct: 1202 TSALDSVTEAKVQEGIEAFQAKYKVTTVSIAHRLTTIRHCDQIILLDSGCIIEQGSHEEL 1261
Query: 1264 I 1264
+
Sbjct: 1262 M 1262
Score = 324 bits (830), Expect = 1e-87
Identities = 192/558 (34%), Positives = 311/558 (55%), Gaps = 11/558 (1%)
Query: 716 VLLFGCFAAIGNGVIFPIFGILTSSMIKTFYEPFDEMKKDSKFWAVMFMLLGFASLLVVT 775
+++ G A+ G P+F + + ++ + +++ + +G A L+
Sbjct: 71 LMIAGTAFAVACGAGMPVFSFIFGRIAMDLMSGVGSAEEKAAKTSLIMVYVGIAMLIACA 130
Query: 776 AQSYFFSVAGYKLIQRIRLLCFEKVVSMEVGWFDEPENSSGSVGARLSADAASVRTIVGD 835
++VA + + RIRLL F V+ ++GW DE +S G++ AR++ D ++ + D
Sbjct: 131 GHVMCWTVAACRQVARIRLLFFRAVLRQDIGWHDE--HSPGALTARMTGDTRVIQNGIND 188
Query: 836 ALGLLVMNLAAALSGLIIAFVASWQLALIILVLIPLIGLNGYVQMKSMKGFSADAKMMYE 895
L +MN + + G I FV SW+L L+++ ++P I + + + + ++ +
Sbjct: 189 KLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITESSRKYFA 248
Query: 896 EASQVANDAVGSIRIVASFCAENKVMELYRKKCEVPMKTGIRQGIISGSGFGVSFFLLFC 955
+A +A + + +IR V +F E+ +E + K GIR+ + S V L++
Sbjct: 249 KAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYV 308
Query: 956 VYALSFYAGARLVESGHTKFSDVFRVFFALTMATVGISQSSSFAPDSSKAKSATASIFRM 1015
Y ++F+ G+ LVE G +D+ F A+ M + G+ + +++++A IF+
Sbjct: 309 SYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKA 368
Query: 1016 IDKKSKIDPSDESGTTLDSVKGEIELRHLSFKYPSRPDIQIFQDLNLTIHSGKTVALVGE 1075
ID+ +D D G + K IE R++ F YP+RP + +F+DL+L I G+ VA G
Sbjct: 369 IDRVPPVD-IDAGGVPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSGA 427
Query: 1076 SGSGKSTVIALLQRFYDPDSGEITLDGIEIRQLQLKWLRQQMGLVSQEPVLFNDTIRSNI 1135
SG GKS+VI L+QRFYDP G + +DG+ +R+L L+ R Q+G+VSQEP LF T+ N+
Sbjct: 428 SGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPNLFAGTMMENV 487
Query: 1136 AYGKGGNATEAEIIAAAELANADRFISGLQQGYDTIVGERGTQLSGGQKQRVAIARAIIK 1195
GK NAT+ E++ A AN I L YDT VG G+ LSGGQKQR+AIARA++K
Sbjct: 488 RMGK-PNATDEEVVEACRQANIHDTIMALPDRYDTPVGPVGSLLSGGQKQRIAIARALVK 546
Query: 1196 SPKILLLDEATSALDAESERVVQDALDKVMV--NRTTVVVAHRLSTVKNADVIAVVKN-- 1251
P ILLLDEATSALD +SE VQ ALD+++ T VV+AHRL+T+++ D I VK+
Sbjct: 547 RPPILLLDEATSALDRKSEMEVQAALDQLIQRGGTTVVVIAHRLATIRDMDRIYYVKHDG 606
Query: 1252 ---GVIVEKGRHETLINV 1266
I E G + L+ +
Sbjct: 607 AEGSRITESGTFDELLEL 624
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.319 0.135 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 133,036,306
Number of Sequences: 164201
Number of extensions: 5514739
Number of successful extensions: 27742
Number of sequences better than 10.0: 1020
Number of HSP's better than 10.0 without gapping: 875
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 22013
Number of HSP's gapped (non-prelim): 3105
length of query: 1266
length of database: 59,974,054
effective HSP length: 122
effective length of query: 1144
effective length of database: 39,941,532
effective search space: 45693112608
effective search space used: 45693112608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 72 (32.3 bits)
Medicago: description of AC144728.6