BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC144720.7 + phase: 2 /pseudo/partial
(1007 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2... 205 6e-52
ADP1_YEAST (P25371) Probable ATP-dependent permease precursor 181 7e-45
BFR1_SCHPO (P41820) Brefeldin A resistance protein 179 3e-44
SCRT_DROME (P45843) Scarlet protein 178 7e-44
SNQ2_YEAST (P32568) SNQ2 protein 177 1e-43
YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W 174 1e-42
CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1 (Pleom... 172 3e-42
PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin 172 5e-42
PDRF_YEAST (Q04182) ATP-dependent permease PDR15 171 7e-42
WHIT_DROME (P10090) White protein 169 3e-41
PDRC_YEAST (Q02785) ATP-dependent permease PDR12 169 3e-41
CDR4_CANAL (O74676) ABC transporter CDR4 169 3e-41
ABG1_HUMAN (P45844) ATP-binding cassette, sub-family G, member 1... 169 4e-41
ABG8_MOUSE (Q9DBM0) ATP-binding cassette, sub-family G, member 8... 168 8e-41
YOH5_YEAST (Q08234) Probable ATP-dependent transporter YOL074C/Y... 167 2e-40
ABG8_RAT (P58428) ATP-binding cassette, sub-family G, member 8 (... 165 5e-40
WHIT_LUCCU (Q05360) White protein 164 8e-40
CDR2_CANAL (P78595) Multidrug resistance protein CDR2 164 8e-40
CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3 164 1e-39
CDR1_CANAL (P43071) Multidrug resistance protein CDR1 164 1e-39
>ABG2_HUMAN (Q9UNQ0) ATP-binding cassette, sub-family G, member 2
(Placenta-specific ATP-binding cassette transporter)
(Breast cancer resistance protein)
Length = 655
Score = 205 bits (521), Expect = 6e-52
Identities = 112/247 (45%), Positives = 158/247 (63%), Gaps = 3/247 (1%)
Query: 416 KAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNESI 475
K K IL N+ G +KPG + AI+GP+G GK++ L LA + ++G +LING
Sbjct: 57 KPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA 115
Query: 476 HSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVR 535
+ FK G+V QDDVV G LTV ENL FSA RL+ ++ EK + RVIE LGL V
Sbjct: 116 N-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIEELGLDKVA 174
Query: 536 NSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALE 595
+S VGT RGVSGG+RKR ++G+E++ +PS+L LDEPT+GLDS+++ +L L+R + +
Sbjct: 175 DSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ 234
Query: 596 GVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDY 655
G I +HQP Y++F +FD L LL G LM +HG A++ YF G + NP D+
Sbjct: 235 GRTIIFSIHQPRYSIFKLFDSLTLLASGRLM-FHGPAQEALGYFESAGYHCEAYNNPADF 293
Query: 656 YIDILEG 662
++DI+ G
Sbjct: 294 FLDIING 300
>ADP1_YEAST (P25371) Probable ATP-dependent permease precursor
Length = 1049
Score = 181 bits (460), Expect = 7e-45
Identities = 108/260 (41%), Positives = 157/260 (59%), Gaps = 7/260 (2%)
Query: 406 ISFRDLTLTLKAQNKH-----ILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGC 460
+SF ++T ++ + N +L ++G +KPG+I AIMG SGAGKTT L LA K
Sbjct: 384 LSFENITYSVPSINSDGVEETVLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTG 443
Query: 461 LVTGSILINGRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVL 520
V+GSI +NG + SF KIIGFV QDD + LTV E + SA RL LS K
Sbjct: 444 HVSGSIKVNGISMDRKSFSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKALSFEAKKA 503
Query: 521 VVERVIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSA 580
V +V+E L + +++ ++G RG+SGG+++RV++ E+V P +L LDEPTSGLD++
Sbjct: 504 RVYKVLEELRIIDIKDRIIGNEFDRGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDAS 563
Query: 581 SSQLLLRALRREALE-GVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYF 639
++ ++ L R + + + + +HQP +F +FD L+LL KG MVY G+AKKV E+
Sbjct: 564 NANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGE-MVYSGNAKKVSEFL 622
Query: 640 SGLGINVPERINPPDYYIDI 659
G P+ N DY IDI
Sbjct: 623 RNEGYICPDNYNIADYLIDI 642
Score = 35.8 bits (81), Expect = 0.59
Identities = 56/275 (20%), Positives = 114/275 (41%), Gaps = 22/275 (8%)
Query: 741 NFLKSKDLSNRKTPGVFKQYKYFLIRVGKQRLREARIQAVDYLILLLAGACLGSITKSSD 800
N L + +++ G +Q R K R ++ +YL+ +L LG++ +
Sbjct: 758 NVLNGDLPTGQQSAGFLQQLSILNSRSFKNMYRNPKLLLGNYLLTILLSLFLGTLYYNVS 817
Query: 801 QTFGA----SGYTYTVIAVSLLCKIAALRSFSLDKLHYWRE-SDSGMSSLAYFLSKDTMD 855
G + ++ L SF+L+++ + +E S++ S LAY++SK +
Sbjct: 818 NDISGFQNRMGLFFFILTYFGFVTFTGLSSFALERIIFIKERSNNYYSPLAYYISKIMSE 877
Query: 856 HFNTVIKPVVYLSMFYF----LTNPRSTFTDNYIVLLCLVYCVTGIAYALSIVFEP-GAA 910
+ P + LS+ + L + F +L+ ++ + I+FE +
Sbjct: 878 VVPLRVVPPILLSLIVYPMTGLNMKDNAFFKCIGILILFNLGISLEILTIGIIFEDLNNS 937
Query: 911 QLWSVLLPVVSTL-----IATQQKDSKILKAIANLCYSKWALQALVIANA------ERYQ 959
+ SVL+ + S L I T+ + K + N +A ++L+I ER
Sbjct: 938 IILSVLVLLGSLLFSGLFINTKNITNVAFKYLKNFSVFYYAYESLLINEVKTLMLKERKY 997
Query: 960 GVWLITRCGSLLKS-GYNLHDWSLCISILILMGVI 993
G+ + ++L + G+ + + I IL L V+
Sbjct: 998 GLNIEVPGATILSTFGFVVQNLVFDIKILALFNVV 1032
>BFR1_SCHPO (P41820) Brefeldin A resistance protein
Length = 1530
Score = 179 bits (454), Expect = 3e-44
Identities = 129/365 (35%), Positives = 196/365 (53%), Gaps = 28/365 (7%)
Query: 373 KEKAQQQENKNLTFSGVLKMATNTEKSKRPFIEISFRDLT--LTLKAQNKHILRNVTGKI 430
KE +E N + G+ EK F S+R+L + +K +++ +L V G +
Sbjct: 859 KESPDNEEELNKEYEGI-------EKGHDIF---SWRNLNYDIQIKGEHRRLLNGVQGFV 908
Query: 431 KPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNESIHSFKKIIGFVPQDDV 490
PG++TA+MG SGAGKTT L+ LA + +VTG +L+NGR +F++ G+V Q DV
Sbjct: 909 VPGKLTALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNGRGLD-STFQRRTGYVQQQDV 967
Query: 491 VHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGTVEKRGVSGG 550
G TV E L FSA R A + EK VE VI+ L ++S +++GT G++
Sbjct: 968 HIGESTVREALRFSAALRQPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPGS-GLNVE 1026
Query: 551 QRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRALRREALEGVNICMVVHQPSYA 609
QRKR +G+E+ +P+LL+ LDEPTSGLDS S+ ++ LR+ A G I +HQPS
Sbjct: 1027 QRKRATIGVELAAKPALLLFLDEPTSGLDSQSAWSIVCFLRKLADAGQAILCTIHQPSAV 1086
Query: 610 LFNMFDDLILLGKGGLMVYHGS----AKKVEEYFSGLG-INVPERINPPDYYIDILEGIA 664
LF+ FD L+LL KGG VY G +K + YF G ++ P+ NP +Y +D++
Sbjct: 1087 LFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYILDVI---- 1142
Query: 665 APGGSSGLSYQDLPVKWMLHNE-YPIPLDMRQHAAQFGIPQSVNSANDLGEVGKTFAGEL 723
G++ + +D W E I ++ + A F + + + E T+A L
Sbjct: 1143 -GAGATATTNRDWHEVWNNSEERKAISAELDKINASFSNSEDKKTLSK--EDRSTYAMPL 1199
Query: 724 WNDVR 728
W V+
Sbjct: 1200 WFQVK 1204
Score = 87.4 bits (215), Expect = 2e-16
Identities = 70/245 (28%), Positives = 119/245 (48%), Gaps = 10/245 (4%)
Query: 420 KHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCL-VTGSILINGRNESIHS- 477
K IL + G + ++G G+G +TFL ++ + V G+ +G +++
Sbjct: 174 KAILSHCHALANAGELVMVLGQPGSGCSTFLRSVTSDTVHYKRVEGTTHYDGIDKADMKK 233
Query: 478 -FKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLS----ADLSKPEKVLVVERVIEF-LGL 531
F + + ++DV +LT E L F+A+CR +L++ E V +I GL
Sbjct: 234 FFPGDLLYSGENDVHFPSLTTAETLDFAAKCRTPNNRPCNLTRQEYVSRERHLIATAFGL 293
Query: 532 QSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRR 591
N+ VG RGVSGG+RKRV + P++ D T GLDS+++ + LR
Sbjct: 294 THTFNTKVGNDFVRGVSGGERKRVTISEGFATRPTIACWDNSTRGLDSSTAFEFVNVLRT 353
Query: 592 EALE-GVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERI 650
A E + + +Q S ++ +FD + +L G +Y+G A K ++YF +G + R
Sbjct: 354 CANELKMTSFVTAYQASEKIYKLFDRICVL-YAGRQIYYGPADKAKQYFLDMGFDCHPRE 412
Query: 651 NPPDY 655
PD+
Sbjct: 413 TTPDF 417
>SCRT_DROME (P45843) Scarlet protein
Length = 666
Score = 178 bits (451), Expect = 7e-44
Identities = 144/495 (29%), Positives = 242/495 (48%), Gaps = 48/495 (9%)
Query: 420 KHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKA-LGCLVTGSILINGRNESIHSF 478
K I+ N TG I+PG + A+MG SG+GKTT +S LA + G +V G ILINGR
Sbjct: 88 KRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMH 147
Query: 479 KKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSV 538
+ G+V QDD+ G+++V E+L F A RL +SK E+ L+++ ++E GL S +
Sbjct: 148 RNH-GYVYQDDLFLGSVSVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTR 206
Query: 539 VGTVE-KRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALEGV 597
+G+ + K+ +SGG+RKR+ +E++ P +L DEPT+GLDS S+Q L+ L A +G
Sbjct: 207 IGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGT 266
Query: 598 NICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYI 657
I +HQPS LF+ F++++LL G + + GS + +F+ G PE NP D+ I
Sbjct: 267 TILCTIHQPSSQLFDNFNNVMLLA-DGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLI 325
Query: 658 DILEGIAAPGGSSGLSYQDLPVKWMLHNEYPIPLDMRQHAAQFGIPQSVNSANDLGEVGK 717
+L +S S Q L QF + +
Sbjct: 326 GVLATDPGYEQASQRSAQHL-------------------CDQFAVSSAAKQ--------- 357
Query: 718 TFAGELWNDVRSNVELRGEKIRLNFLKSKDLSNRKTPGVFKQYKYFLIRVGKQRLREARI 777
D+ N+E+ + NF ++ + + +K++ +R LR+ I
Sbjct: 358 -------RDMLVNLEIHMAQSG-NFPFDTEVESFRGVAWYKRFHVVWLRAIVTLLRDPTI 409
Query: 778 QAVDYL----ILLLAGACLGSITKSSDQTFGA-SGYTYTVIAVSLLCKI-AALRSFSLDK 831
Q + ++ + + GAC T+ S A G + +I+ + + + L F
Sbjct: 410 QWLRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGF 469
Query: 832 LHYWRESDSGMSSLAYFLSKDTMDHF-NTVIKPVVYLSMFYFLTNPRSTFTDNYIVLLCL 890
+ RE+ SG+ S + + + + +I+P++++ + Y+LT RSTF + +C+
Sbjct: 470 PLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCV 529
Query: 891 VYCVTGIAYALSIVF 905
V V +A A F
Sbjct: 530 V-LVMNVATACGCFF 543
>SNQ2_YEAST (P32568) SNQ2 protein
Length = 1501
Score = 177 bits (449), Expect = 1e-43
Identities = 153/504 (30%), Positives = 237/504 (46%), Gaps = 61/504 (12%)
Query: 412 TLTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGR 471
T+ + + +L NV+G PG +TA+MG SGAGKTT L+ LA + +G ++TG +L+NGR
Sbjct: 861 TIPYEGGKRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQRNVG-IITGDMLVNGR 919
Query: 472 NESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGL 531
SF++ G+V Q D+ LTV E+L FSA+ R L EK+ VE++I LG+
Sbjct: 920 PIDA-SFERRTGYVQQQDIHIAELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGM 978
Query: 532 QSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRALR 590
+ ++VG V G++ QRK++++G+E+V +P LL+ LDEPTSGLDS SS +++ LR
Sbjct: 979 EEYAEALVGEVGC-GLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLR 1037
Query: 591 REALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKK----VEEYFSGLGI-N 645
+ + G +I +HQPS LF FD L+LL KGG VY G K + YF G
Sbjct: 1038 KLSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNYFERNGARK 1097
Query: 646 VPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEYPIPLDMRQHAAQFGIPQS 705
NP +Y ILE I A G++ +D KW+ E+
Sbjct: 1098 CDSSENPAEY---ILEAIGA--GATASVKEDWHEKWLNSVEF------------------ 1134
Query: 706 VNSANDLGEVGKTFAGELWNDVRSNVELRGEKIRLNFLKSKDLSNRKTPGVFKQYKYFLI 765
E K +L ND+ S E + E D ++ Q++Y LI
Sbjct: 1135 --------EQTKEKVQDLINDL-SKQETKSE--------VGDKPSKYATSYAYQFRYVLI 1177
Query: 766 RVGKQRLREARIQAVDYLILLLAGACLGSITKSSDQTFGASGYTYTVIAVSLLCKIAAL- 824
R R +++L+ G +G + +++ +S++ A+
Sbjct: 1178 RTSTSFWRSLNYIMSKMMLMLVGGLYIGFTFFNVGKSYVGLQNAMFAAFISIILSAPAMN 1237
Query: 825 ----RSFSLDKLHYWRESDSGMSSLAYFLSKDTMDH------FNTVIKPVVYLSMFYFLT 874
R+ + +L RES S M + L + F+T+ Y + F
Sbjct: 1238 QIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSELPYHLFFSTIFFVSSYFPLRIFFE 1297
Query: 875 NPRS-TFTDNYIVLLCLVYCVTGI 897
RS + NY ++ L Y G+
Sbjct: 1298 ASRSAVYFLNYCIMFQLYYVGLGL 1321
Score = 84.3 bits (207), Expect = 1e-15
Identities = 67/252 (26%), Positives = 123/252 (48%), Gaps = 11/252 (4%)
Query: 408 FRDLTLTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKA--LGCLVTGS 465
F+ + + + I+ NV + G + ++G GAG ++FL AG+ V+G
Sbjct: 161 FKGIKAKRHQKMRQIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGE 220
Query: 466 ILING--RNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSA----DLSKPEKV 519
+ +G + E + +K + + + DV LTV++ L F+ C+ A ++SK E +
Sbjct: 221 VAYDGIPQEEMMKRYKADVIYNGELDVHFPYLTVKQTLDFAIACKTPALRVNNVSKKEYI 280
Query: 520 LVVERVIEFL-GLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLD 578
+ + GL+ N+ VG RGVSGG+RKRV++ + + S+ D T GLD
Sbjct: 281 ASRRDLYATIFGLRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLD 340
Query: 579 SASSQLLLRALR-REALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEE 637
++++ +A+R L + ++Q S ++ FD + +L G +Y G + +
Sbjct: 341 ASTALEYAKAIRIMTNLLKSTAFVTIYQASENIYETFDKVTVL-YSGKQIYFGLIHEAKP 399
Query: 638 YFSGLGINVPER 649
YF+ +G P R
Sbjct: 400 YFAKMGYLCPPR 411
>YN99_YEAST (P53756) Probable ATP-dependent transporter YNR070W
Length = 1333
Score = 174 bits (440), Expect = 1e-42
Identities = 111/282 (39%), Positives = 169/282 (59%), Gaps = 14/282 (4%)
Query: 412 TLTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGR 471
T+ + + +L +V+G PG +TA++G SGAGKTT L+ LA + +G +TG +L++G
Sbjct: 737 TIPHSSGQRKLLDSVSGYCVPGTLTALIGESGAGKTTLLNTLAQRNVGT-ITGDMLVDGL 795
Query: 472 NESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGL 531
SFK+ G+V Q D+ LTV+E+L FSA+ R + EK+ VE++I L +
Sbjct: 796 PMDA-SFKRRTGYVQQQDLHVAELTVKESLQFSARMRRPQSIPDAEKMEYVEKIISILEM 854
Query: 532 QSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRALR 590
Q ++VG + G++ QRK++++G+E+V +P LL+ LDEPTSGLDS S+ +++ L+
Sbjct: 855 QEFSEALVGEIGY-GLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQSAWAVVKMLK 913
Query: 591 REALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYFSGLGI-N 645
R AL G +I +HQPS LF FD L+LLGKGG +Y G ++ V +YF G
Sbjct: 914 RLALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIKYFEKNGARK 973
Query: 646 VPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEY 687
+ NP +Y ILE I A G++ Q+ P W +EY
Sbjct: 974 CQQNENPAEY---ILEAIGA--GATASVQQNWPDIWQKSHEY 1010
Score = 103 bits (258), Expect = 2e-21
Identities = 81/271 (29%), Positives = 134/271 (48%), Gaps = 20/271 (7%)
Query: 420 KHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKA---LGCLVTGSILING--RNES 474
K IL+NV+ K G + ++G GAG T+FL + AG+ G + TG I +G + E
Sbjct: 43 KIILKNVSLLAKSGEMVLVLGRPGAGCTSFLKSAAGETSQFAGGVTTGHISYDGIPQKEM 102
Query: 475 IHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSA----DLSKPEKVLVV-ERVIEFL 529
+ +K + + + DV +LTV++ L F+ C++ A +++K E + E +
Sbjct: 103 MQHYKPDVIYNGEQDVHFPHLTVKQTLDFAISCKMPAKRVNNVTKEEYITANREFYAKIF 162
Query: 530 GLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRAL 589
GL ++ VG GVSGG+RKRV++ + + S+ D T GLDS+++ RA+
Sbjct: 163 GLTHTFDTKVGNDFISGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDSSTALEFARAI 222
Query: 590 RREA-LEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPE 648
R L G + V+Q S ++ FD + +L G ++ G + ++YF +G P
Sbjct: 223 RTMTNLLGTTALVTVYQASENIYETFDKVTVL-YAGRQIFCGKTTEAKDYFENMGYLCPP 281
Query: 649 RINPPDYYIDILEGIAAPGG----SSGLSYQ 675
R + +Y L I P G G YQ
Sbjct: 282 RQSTAEY----LTAITDPNGLHEIKPGFEYQ 308
>CGR1_CANGA (O74208) ATP-binding cassette transporter CGR1
(Pleomorphic drug resistance homolog)
Length = 1542
Score = 172 bits (437), Expect = 3e-42
Identities = 113/316 (35%), Positives = 172/316 (53%), Gaps = 16/316 (5%)
Query: 415 LKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNES 474
+K + + IL NV G +KPG +TA+MG SGAGKTT L LA + ++TG +++NGR
Sbjct: 896 IKTEVRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERTTMGVITGDVMVNGRPRD 955
Query: 475 IHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSV 534
SF + IG+ Q D+ TV E+L FSA R + +S EK VE VI+ L +++
Sbjct: 956 T-SFSRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNEYVEAVIKILEMETY 1014
Query: 535 RNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRALRREA 593
++VVG V G++ QRKR+ +G+E+ +P LL+ LDEPTSGLDS ++ + +++ A
Sbjct: 1015 ADAVVG-VPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWATCQLMKKLA 1073
Query: 594 LEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYFSGLGIN-VPE 648
G I +HQPS L FD L+ L KGG VY G K + +YF G + P
Sbjct: 1074 NHGQAILCTIHQPSAMLMQEFDRLLFLQKGGQTVYFGDLGKGCKTMIKYFEDHGAHKCPP 1133
Query: 649 RINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEYPIPLDMRQHAAQFGIPQSVNS 708
NP ++ ++++ AAPG + Y ++ W ++ ++Q Q S
Sbjct: 1134 DANPAEWMLEVVG--AAPGSHANQDYHEV---WRNSEQFK---QVKQELEQMEKELSQKE 1185
Query: 709 ANDLGEVGKTFAGELW 724
++ + K FA LW
Sbjct: 1186 LDNDEDANKEFATSLW 1201
Score = 94.0 bits (232), Expect = 2e-18
Identities = 73/250 (29%), Positives = 125/250 (49%), Gaps = 15/250 (6%)
Query: 422 ILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILI--NGR--NESIHS 477
IL+ + G +KPG + ++G G+G TT L +++ G ++ +I NG NE
Sbjct: 174 ILKPMDGLLKPGELLVVLGRPGSGCTTLLKSISSTTHGFQISKDSVISYNGLTPNEIKKH 233
Query: 478 FKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVL-------VVERVIEFLG 530
++ + + + D+ +LTV + L A RL ++ + V V + + G
Sbjct: 234 YRGEVVYNAEADIHLPHLTVYQTLVTVA--RLKTPQNRVKGVTREDFANHVTDVAMATYG 291
Query: 531 LQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALR 590
L R++ VG RGVSGG+RKRV++ + D T GLDSA++ +RAL+
Sbjct: 292 LSHTRDTKVGNDLVRGVSGGERKRVSIAEVWICGSKFQCWDNATRGLDSATALEFVRALK 351
Query: 591 REALEGVNICMV-VHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPER 649
+A N+ V ++Q S +N+F+ + +L + G +Y G A+ + YF +G P+R
Sbjct: 352 TQAHIAKNVATVAIYQCSQDAYNLFNKVSVLYE-GYQIYFGDAQHAKVYFQKMGYFCPKR 410
Query: 650 INPPDYYIDI 659
PD+ I
Sbjct: 411 QTIPDFLTSI 420
>PDR5_YEAST (P33302) Suppressor of toxicity of sporidesmin
Length = 1511
Score = 172 bits (435), Expect = 5e-42
Identities = 108/279 (38%), Positives = 160/279 (56%), Gaps = 13/279 (4%)
Query: 415 LKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNES 474
+KA+ + IL NV G +KPG +TA+MG SGAGKTT L LA + ++TG IL+NG
Sbjct: 880 IKAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGDILVNGIPRD 939
Query: 475 IHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSV 534
SF + IG+ Q D+ TV E+L FSA R A++S EK VE VI+ L ++
Sbjct: 940 -KSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKY 998
Query: 535 RNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRALRREA 593
++VVG V G++ QRKR+ +G+E+ +P LL+ LDEPTSGLDS ++ + + +++ A
Sbjct: 999 ADAVVG-VAGEGLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLA 1057
Query: 594 LEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYFSGLGIN-VPE 648
G I +HQPS L FD L+ + +GG VY G K + +YF G + P
Sbjct: 1058 NHGQAILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPA 1117
Query: 649 RINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEY 687
NP ++ ++++ AAPG + Y ++ W EY
Sbjct: 1118 DANPAEWMLEVVG--AAPGSHANQDYYEV---WRNSEEY 1151
Score = 98.6 bits (244), Expect = 7e-20
Identities = 149/605 (24%), Positives = 243/605 (39%), Gaps = 81/605 (13%)
Query: 382 KNLTFSGV-LKMATNTEKSKRPF--IEISFRDLTLTLKAQNKHILRNVTGKIKPGRITAI 438
KNL+ SG +A + P+ ++ R + + IL+ + G + PG + +
Sbjct: 132 KNLSASGASADVAYQSTVVNIPYKILKSGLRKFQRSKETNTFQILKPMDGCLNPGELLVV 191
Query: 439 MGPSGAGKTTFLSALAGKALGCLVTGSILINGRNESIHSFKKI----IGFVPQDDVVHGN 494
+G G+G TT L +++ G + I+ S KK + + + DV +
Sbjct: 192 LGRPGSGCTTLLKSISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVVYNAEADVHLPH 251
Query: 495 LTVEENLWFSA-----QCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGTVEKRGVSG 549
LTV E L A Q R+ + + E + GL RN+ VG RGVSG
Sbjct: 252 LTVFETLVTVARLKTPQNRIKGVDRESYANHLAEVAMATYGLSHTRNTKVGNDIVRGVSG 311
Query: 550 GQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREA-LEGVNICMVVHQPSY 608
G+RKRV++ + D T GLDSA++ +RAL+ +A + + + ++Q S
Sbjct: 312 GERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALKTQADISNTSATVAIYQCSQ 371
Query: 609 ALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYIDILEGIAAPGG 668
+++F+ + +L G +Y+G A K ++YF +G P R D+ L + +P
Sbjct: 372 DAYDLFNKVCVL-DDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADF----LTSVTSP-- 424
Query: 669 SSGLSYQDLPVKWMLHNEYPIPLDMRQHAAQFGIPQSVNSAND-------LGEVGKTFAG 721
+E + DM + IPQ+ ND E+ K
Sbjct: 425 ----------------SERTLNKDMLKKGIH--IPQTPKEMNDYWVKSPNYKELMKEVDQ 466
Query: 722 ELWNDVRSNVELRGEKIRLNFLKSKDLSNRKTPGVFKQYKYFLIRVGKQRLREARIQAVD 781
L ND ++ E E K S+ T Q KY LIR RLR I
Sbjct: 467 RLLNDDEASREAIKEAHIAKQSKRARPSSPYTVSYMMQVKYLLIR-NMWRLRN-NIGFTL 524
Query: 782 YLIL------LLAGACLGSITKSSDQT---FGASGYTYTVI--AVSLLCKIAAL------ 824
++IL L+ G+ I K D + F S + ++ A S L +I +L
Sbjct: 525 FMILGNCSMALILGSMFFKIMKKGDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPI 584
Query: 825 ----RSFSLDKLHYWRESDSGMSSLAYFLSKDTMDHFNTVIKPVVYLSMFYFLTNPRSTF 880
R++SL Y +D+ S L+ SK +I V + +FYFL + R
Sbjct: 585 TEKHRTYSL----YHPSADAFASVLSEIPSK--------LIIAVCFNIIFYFLVDFRRNG 632
Query: 881 TDNYIVLLCLVYCVTGIAYALSIVFEPGAAQLWSVLLPVVSTLIATQQKDSKILKAIANL 940
+ LL + V +++ V L ++P L+A + L
Sbjct: 633 GVFFFYLLINIVAVFSMSHLFRCVGSL-TKTLSEAMVPASMLLLALSMYTGFAIPKKKIL 691
Query: 941 CYSKW 945
+SKW
Sbjct: 692 RWSKW 696
>PDRF_YEAST (Q04182) ATP-dependent permease PDR15
Length = 1529
Score = 171 bits (434), Expect = 7e-42
Identities = 112/288 (38%), Positives = 162/288 (55%), Gaps = 15/288 (5%)
Query: 408 FRDLT--LTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGS 465
+RDL + +K + IL NV G +KPG +TA+MG SGAGKTT L LA + ++TG+
Sbjct: 886 WRDLCYDVPIKGGQRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGN 945
Query: 466 ILINGRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERV 525
I ++GR SF + IG+ Q D+ TV E+L FSA R + +S EK VE V
Sbjct: 946 IFVDGRLRD-ESFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNRYVEEV 1004
Query: 526 IEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQL 584
I+ L +Q ++VVG V G++ QRKR+ +G+E+ P LL+ LDEPTSGLDS ++
Sbjct: 1005 IKILEMQQYSDAVVG-VAGEGLNVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQTAWD 1063
Query: 585 LLRALRREALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYFS 640
+ +R+ A G I +HQPS L FD L+ L KGG VY G K + +YF
Sbjct: 1064 TCQLMRKLATHGQAILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFE 1123
Query: 641 GLGIN-VPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEY 687
G + P NP ++ ++++ AAPG + Y ++ W +EY
Sbjct: 1124 SKGAHKCPPDANPAEWMLEVVG--AAPGSHATQDYNEV---WRNSDEY 1166
Score = 91.3 bits (225), Expect = 1e-17
Identities = 69/248 (27%), Positives = 118/248 (46%), Gaps = 11/248 (4%)
Query: 422 ILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNESIHSFKKI 481
IL+ + G + PG + ++G G+G TT L +++ + G + +++ S +K
Sbjct: 185 ILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNSHGFKIAKDSIVSYNGLSSSDIRKH 244
Query: 482 ----IGFVPQDDVVHGNLTVEENLWFSA-----QCRLSADLSKPEKVLVVERVIEFLGLQ 532
+ + + D+ +LTV + L+ A Q R+ + V E + GL
Sbjct: 245 YRGEVVYNAESDIHLPHLTVYQTLFTVARMKTPQNRIKGVDREAYANHVTEVAMATYGLS 304
Query: 533 SVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRRE 592
R++ VG RGVSGG+RKRV++ + D T GLDSA++ +RAL+ +
Sbjct: 305 HTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGLDSATALEFIRALKTQ 364
Query: 593 ALEGVNICMV-VHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERIN 651
A G V ++Q S +++FD + +L G +Y G AK ++YF +G P R
Sbjct: 365 ADIGKTAATVAIYQCSQDAYDLFDKVCVL-DDGYQLYFGPAKDAKKYFQDMGYYCPPRQT 423
Query: 652 PPDYYIDI 659
D+ I
Sbjct: 424 TADFLTSI 431
>WHIT_DROME (P10090) White protein
Length = 687
Score = 169 bits (429), Expect = 3e-41
Identities = 89/250 (35%), Positives = 153/250 (60%), Gaps = 5/250 (2%)
Query: 415 LKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKA---LGCLVTGSILINGR 471
+ A KH+L+NV G PG + A+MG SGAGKTT L+ALA ++ + +G L+NG+
Sbjct: 105 IPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQ 164
Query: 472 NESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGL 531
+ +V QDD+ G+LT E+L F A R+ L+ ++V V++VI+ L L
Sbjct: 165 PVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSL 224
Query: 532 QSVRNSVVGTVEK-RGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALR 590
+++++G + +G+SGG+RKR+ E + +P LL+ DEPTSGLDS ++ +++ L+
Sbjct: 225 SKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLK 284
Query: 591 REALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERI 650
+ + +G + + +HQPS LF +FD ++L+ + G + + G+ + ++FS +G P
Sbjct: 285 KLSQKGKTVILTIHQPSSELFELFDKILLMAE-GRVAFLGTPSEAVDFFSYVGAQCPTNY 343
Query: 651 NPPDYYIDIL 660
NP D+Y+ +L
Sbjct: 344 NPADFYVQVL 353
>PDRC_YEAST (Q02785) ATP-dependent permease PDR12
Length = 1511
Score = 169 bits (428), Expect = 3e-41
Identities = 103/259 (39%), Positives = 160/259 (61%), Gaps = 12/259 (4%)
Query: 410 DLTLTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILIN 469
D T+ + +L +V G +KPG++TA+MG SGAGKTT L+ LA + ++TG +L+N
Sbjct: 848 DYTIPYDGATRKLLSDVFGYVKPGKMTALMGESGAGKTTLLNVLAQRINMGVITGDMLVN 907
Query: 470 GRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFL 529
+ SF + G+V Q D L+V E+L F+A+ R + + EK VE++I L
Sbjct: 908 AKPLPA-SFNRSCGYVAQADNHMAELSVRESLRFAAELRQQSSVPLEEKYEYVEKIITLL 966
Query: 530 GLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRA 588
G+Q+ ++VG RG++ QRK++++G+E+V +PSLL+ LDEPTSGLDS S+ +++
Sbjct: 967 GMQNYAEALVGKTG-RGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQSAWSIVQF 1025
Query: 589 LRREALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYF---SG 641
+R A G +I +HQPS LF FD L+LL KGG MVY G +++ + +YF SG
Sbjct: 1026 MRALADSGQSILCTIHQPSATLFEQFDRLLLLKKGGKMVYFGDIGPNSETLLKYFERQSG 1085
Query: 642 LGINVPERINPPDYYIDIL 660
+ V E NP +Y ++ +
Sbjct: 1086 MKCGVSE--NPAEYILNCI 1102
Score = 99.8 bits (247), Expect = 3e-20
Identities = 155/720 (21%), Positives = 296/720 (40%), Gaps = 113/720 (15%)
Query: 307 ASSSAVPTEKGKTPSGLM-HMMHEIENDPHVNYNPNTGKETRHKSATKEKQPQTNTQIFK 365
AS V E S L H+ + + N+ + + + HK+ + + N F
Sbjct: 31 ASEGQVDNEDLAATSQLSRHLSNILSNEEGIERLESMARVISHKTKKEMDSFEINDLDFD 90
Query: 366 -----YAYAQLEKEKAQQQENKNLTFSGVLKMATNTEKSKRPFIEISFRDLT-------- 412
+ + E+ + + + F + + + + P +E FR++
Sbjct: 91 LRSLLHYLRSRQLEQGIEPGDSGIAFKNLTAVGVDASAAYGPSVEEMFRNIASIPAHLIS 150
Query: 413 -LTLKAQN--KHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCL-VTGSILI 468
T K+ ++I++N TG ++ G + ++G GAG +TFL L+G+ + V G
Sbjct: 151 KFTKKSDVPLRNIIQNCTGVVESGEMLFVVGRPGAGCSTFLKCLSGETSELVDVQGEFSY 210
Query: 469 NG--RNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLS-ADLSKPEKVLVVERV 525
+G ++E + +K + + P+ D +TV+E + F+ +C+ + K + V+ +
Sbjct: 211 DGLDQSEMMSKYKGYVIYCPELDFHFPKITVKETIDFALKCKTPRVRIDKMTRKQYVDNI 270
Query: 526 IEF----LGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSAS 581
+ GL+ + VG RGVSGG+RKRV++ M S+ D T GLD+++
Sbjct: 271 RDMWCTVFGLRHTYATKVGNDFVRGVSGGERKRVSLVEAQAMNASIYSWDNATRGLDAST 330
Query: 582 SQLLLRALRREALEGVNICMV-VHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFS 640
+ +A+R N +V ++Q ++ +FD +L G +Y G A K YF
Sbjct: 331 ALEFAQAIRTATNMVNNSAIVAIYQAGENIYELFDKTTVL-YNGRQIYFGPADKAVGYFQ 389
Query: 641 GLGINVPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEYPIPLDMRQHAAQF 700
+G P R+ ++ + + + L +K ++ P + +++F
Sbjct: 390 RMGWVKPNRMTSAEFLTSV---------TVDFENRTLDIKPGYEDKVP------KSSSEF 434
Query: 701 GIPQSVNSANDLGEVGKTFAGELWNDVRSNVELRGEKIRLNFLKSKDL------SNRKTP 754
+ ++ D E+ +T+ +D +S + + RL+ K + L +++
Sbjct: 435 --EEYWLNSEDYQELLRTY-----DDYQSRHPVNETRDRLDVAKKQRLQQGQRENSQYVV 487
Query: 755 GVFKQYKYFLIRVGKQRLREARIQAVDYL-ILLLAGACLGSI-----TKSSDQTFGA--- 805
+ Q Y +IR G QR++ YL L+ +GS+ KS T GA
Sbjct: 488 NYWTQVYYCMIR-GFQRVKGDSTYTKVYLSSFLIKALIIGSMFHKIDDKSQSTTAGAYSR 546
Query: 806 SGYTYTVIAVSLLCKIAAL-RSFSLDKLHYWRESDSGMSSLAYFLSKDTMDHFNTVIKPV 864
G + V+ + + +A + SFS + +S S Y LS +++ T P
Sbjct: 547 GGMLFYVLLFASVTSLAEIGNSFSSRPVIVKHKSYS-----MYHLSAESLQEIITEF-PT 600
Query: 865 VYLSMFYFLTNPRSTFTDNYIVLLCLV-YCVTGIAYALSIVFEPGAAQLWSVLLPVVSTL 923
+++ IV+LCL+ Y + + Y F+ + L
Sbjct: 601 KFVA----------------IVILCLITYWIPFMKYEAGAFFQ------------YILYL 632
Query: 924 IATQQKDSKILKAIANLCYSKWALQALVIANAERYQGVWLITRC---GSLLKSGYNLHDW 980
+ QQ S I K +A + S +A G+W++ C G +L G +H W
Sbjct: 633 LTVQQCTSFIFKFVATMSKSG--------VDAHAVGGLWVLMLCVYAGFVLPIG-EMHHW 683
>CDR4_CANAL (O74676) ABC transporter CDR4
Length = 1490
Score = 169 bits (428), Expect = 3e-41
Identities = 110/289 (38%), Positives = 171/289 (59%), Gaps = 16/289 (5%)
Query: 408 FRDLT--LTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGK-ALGCLVTG 464
+RDLT + +K++++ IL +V+G +KPG++TA+MG SGAGKTT L+AL+ + G + G
Sbjct: 848 WRDLTYQVKIKSEDRVILDHVSGWVKPGQVTALMGASGAGKTTLLNALSDRLTTGVVTEG 907
Query: 465 SILINGRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVER 524
L+NGR SF++ IG+V Q D+ TV E L F+A R +S+ EK V+
Sbjct: 908 IRLVNGRPLD-SSFQRSIGYVQQQDLHLETSTVREALEFAAYLRQPKSVSRKEKNEYVDY 966
Query: 525 VIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQ 583
+I L ++ ++VVG V G++ QRKR+++G+E+V +P LL+ LDEPTSGLDS ++
Sbjct: 967 IIRLLEMEQYADAVVG-VSGEGLNVEQRKRLSIGVELVAKPKLLVFLDEPTSGLDSQTAW 1025
Query: 584 LLLRALRREALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKK----VEEYF 639
+ + +R+ A G I +HQPS L FD L+ L +GG VY G K + YF
Sbjct: 1026 SICKLIRKLADNGQAILCTIHQPSAILLAEFDRLLFLQRGGQTVYFGDLGKNFTTLINYF 1085
Query: 640 SGLGI-NVPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEY 687
G P NP ++ ++++ AAPG + Y D+ W+ +E+
Sbjct: 1086 EKYGAPKCPPEANPAEWMLEVIG--AAPGSKANQDYYDV---WLKSSEF 1129
Score = 113 bits (282), Expect = 3e-24
Identities = 81/266 (30%), Positives = 132/266 (49%), Gaps = 17/266 (6%)
Query: 403 FIEISFRDLTLTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLV 462
++ + FR+ L IL+ + G IKPG +T ++G GAG +TFL +A + G +
Sbjct: 153 YLSLFFREYILRHTGPTFDILKPMDGLIKPGELTVVLGRPGAGCSTFLKTIASQTYGYHI 212
Query: 463 TGSILINGRNESIHSFKKI----IGFVPQDDVVHGNLTVEENLWFSAQCR--------LS 510
+I + + H KK + + + + LTV + L F+A+ R +S
Sbjct: 213 DKDSVIRYNSLTPHEIKKHYRGEVVYCAETENHFPQLTVGDTLEFAAKMRTPQNRPLGVS 272
Query: 511 ADLSKPEKVLVVERVIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLML 570
D VV V GL RN+ VG RGVSGG+RKRV++ + +
Sbjct: 273 RDAYARHLAAVVMAVY---GLSHTRNTKVGNDFIRGVSGGERKRVSIAEITLNNAMVQCW 329
Query: 571 DEPTSGLDSASSQLLLRALRREA-LEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYH 629
D T GLDSA++ +RAL+ A + + ++Q S +++FD ++L+ + G +Y
Sbjct: 330 DNSTRGLDSATALEFIRALKASADIVHTTPLVAIYQCSQDAYDLFDKVVLMYQ-GYQIYF 388
Query: 630 GSAKKVEEYFSGLGINVPERINPPDY 655
GSAKK ++YF +G P+R D+
Sbjct: 389 GSAKKAKQYFIDMGYECPQRQTTADF 414
>ABG1_HUMAN (P45844) ATP-binding cassette, sub-family G, member 1
(White protein homolog) (ATP-binding cassette
transporter 8)
Length = 678
Score = 169 bits (427), Expect = 4e-41
Identities = 155/533 (29%), Positives = 256/533 (47%), Gaps = 61/533 (11%)
Query: 400 KRPFIEISFRDLTLTL-------KAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSA 452
+R + I FRDL+ ++ K K +L+ ++GK G + AIMGPSGAGK+T ++
Sbjct: 71 RRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 130
Query: 453 LAG-KALGCLVTGSILINGRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSA 511
LAG + G + G++LING + F+K+ ++ QDD++ +LTV+E + SA +L
Sbjct: 131 LAGYRETG--MKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQE 188
Query: 512 -DLSKPEKVLVVERVIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLML 570
D + E +V+ ++ LGL S N+ G++ SGGQRKR+ + LE+V P ++
Sbjct: 189 KDEGRRE---MVKEILTALGLLSCANTRTGSL-----SGGQRKRLAIALELVNNPPVMFF 240
Query: 571 DEPTSGLDSASSQLLLRALRREALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG 630
DEPTSGLDSAS ++ ++ A G +I +HQPS LF +FD L +L + G VY G
Sbjct: 241 DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQ-GQCVYRG 299
Query: 631 SAKKVEEYFSGLGINVPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEYPIP 690
+ Y LG+N P NP D+ +++ G EY
Sbjct: 300 KVCNLVPYLRDLGLNCPTYHNPADFVMEVASG-----------------------EYGDQ 336
Query: 691 LDMRQHAAQFGIPQSVNSANDLGEVGKTFAGELWNDVRSNVELRGEKIRLNFLKSKDLSN 750
A + G+ S + DLG + LW+ R + E++ K RL L+ KD S+
Sbjct: 337 NSRLVRAVREGMCDS-DHKRDLGGDAEV-NPFLWH--RPSEEVKQTK-RLKGLR-KDSSS 390
Query: 751 RKTPGVFKQ--YKYFLIRVGKQRLREARIQAVDYL-------ILLLAGACLGSITKSSDQ 801
+ F F I + L R + +L I LL G I + +
Sbjct: 391 MEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKK 450
Query: 802 TFGASGYT-YTVIAVSLLCKIAALRSFSLDKLHYWRESDSGMSSL-AYFLSKDTMDHFNT 859
SG+ ++++ + + + +F L+ + RE + SL AY+L+K D
Sbjct: 451 VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQ 510
Query: 860 VIKPVVYLSMFYFLTNPRSTFTDNYIVLLCLVYCVTGIAYALSIVFEPGAAQL 912
++ PV Y S+ Y++T+ S +++ L + +A +L ++ + L
Sbjct: 511 IMFPVAYCSIVYWMTSQPSDAV-RFVLFAALGTMTSLVAQSLGLLIGAASTSL 562
>ABG8_MOUSE (Q9DBM0) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 673
Score = 168 bits (425), Expect = 8e-41
Identities = 140/498 (28%), Positives = 232/498 (46%), Gaps = 54/498 (10%)
Query: 423 LRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGC-LVTGSILINGRNESIHSFKKI 481
+RN++ K++ G++ AI+G SG G+ + L + G+ G + +G I ING+ + +K
Sbjct: 89 IRNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKMKSGQIWINGQPSTPQLVRKC 148
Query: 482 IGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGT 541
+ V Q D + NLTV E L F AQ RL S+ ++ VE VI L L+ N+ VG
Sbjct: 149 VAHVRQHDQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCANTRVGN 208
Query: 542 VEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALEGVNICM 601
RGVSGG+R+RV++G++++ P +L+LDEPTSGLDS ++ L+ L R A + +
Sbjct: 209 TYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVTTLSRLAKGNRLVLI 268
Query: 602 VVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYIDILE 661
+HQP +F +F DL+LL G +Y G+A+++ +YF+ +G P NP D+Y+D+
Sbjct: 269 SLHQPRSDIFRLF-DLVLLMTSGTPIYLGAAQQMVQYFTSIGHPCPRYSNPADFYVDLTS 327
Query: 662 GIAAPGGSSGLSYQDLPVKWMLHNEYPIPLDMRQHAAQFGIPQSVNSANDLG-EVGKTFA 720
+D R + + S L E + F
Sbjct: 328 -----------------------------IDRRSKEREVATVEKAQSLAALFLEKVQGFD 358
Query: 721 GELWNDVRSNVELRGEKIRLNFLKSKDLSNR-KTPGVFKQYKYFLIRVGKQRLREARIQA 779
LW + + L + D + PG+ +Q+ + R R+
Sbjct: 359 DFLWKAEAKELNTSTHTVSLTLTQDTDCGTAVELPGMIEQFSTLIRRQISNDFRD----- 413
Query: 780 VDYLILLLAGACLGS-ITKSSDQTFGASGYTYTVIAVSLLCKIAALRSFS-----LDKLH 833
+ L++ + ACL S I GA ++ A +LL I AL F+ + K H
Sbjct: 414 LPTLLIHGSEACLMSLIIGFLYYGHGAKQLSFMDTA-ALLFMIGALIPFNVILDVVSKCH 472
Query: 834 ------YWRESDSGMSSLAYFLSKDTMDHFNTVIKPVVYLSMFYFLTNPR---STFTDNY 884
Y+ D ++ YF +K + ++Y Y+LTN R F ++
Sbjct: 473 SERSMLYYELEDGLYTAGPYFFAKILGELPEHCAYVIIYAMPIYWLTNLRPVPELFLLHF 532
Query: 885 IVLLCLVYCVTGIAYALS 902
+++ +V+C +A A S
Sbjct: 533 LLVWLVVFCCRTMALAAS 550
>YOH5_YEAST (Q08234) Probable ATP-dependent transporter
YOL074C/YOL075C
Length = 1294
Score = 167 bits (422), Expect = 2e-40
Identities = 99/285 (34%), Positives = 161/285 (55%), Gaps = 22/285 (7%)
Query: 397 EKSKRPFIEISFRDLTLTL--------------KAQNKHILRNVTGKIKPGRITAIMGPS 442
EK K I I D+ L + + K IL++V KPG I AIMGPS
Sbjct: 670 EKGKNIHITIKLEDIDLRVIFSAPFSNWKEGNFHHETKEILQSVNAIFKPGMINAIMGPS 729
Query: 443 GAGKTTFLSALAGKALGCL-----VTGSILINGRNESIHSFKKIIGFVPQDDV-VHGNLT 496
G+GK++ L+ ++G+ + +GSI+ N S FK + +V QDD + LT
Sbjct: 730 GSGKSSLLNLISGRLKSSVFAKFDTSGSIMFNDIQVSELMFKNVCSYVSQDDDHLLAALT 789
Query: 497 VEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVN 556
V+E L ++A RL L++ E++ + +I LGL+ N+++G +G+SGG+++RV
Sbjct: 790 VKETLKYAAALRLH-HLTEAERMERTDNLIRSLGLKHCENNIIGNEFVKGISGGEKRRVT 848
Query: 557 VGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALE-GVNICMVVHQPSYALFNMFD 615
+G++++ +P +L+LDEPTSGLDS +S +L L + E G I + +HQP LF F
Sbjct: 849 MGVQLLNDPPILLLDEPTSGLDSFTSATILEILEKLCREQGKTIIITIHQPRSELFKRFG 908
Query: 616 DLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYIDIL 660
+++LL K G ++GS ++ YF+ LG N P N D+++D++
Sbjct: 909 NVLLLAKSGRTAFNGSPDEMIAYFTELGYNCPSFTNVADFFLDLI 953
Score = 162 bits (409), Expect = 5e-39
Identities = 97/282 (34%), Positives = 160/282 (56%), Gaps = 25/282 (8%)
Query: 399 SKRPFIEISFRDLTLTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKAL 458
S+ P I + RDL++ N ++ + + G + A+MG SG+GKTT L+ LA K
Sbjct: 21 SRIPRISLHVRDLSIVASKTNTTLVNTFSMDLPSGSVMAVMGGSGSGKTTLLNVLASKIS 80
Query: 459 GCLV-TGSIL-------------------INGRNESIHSFKKIIGFVPQDDVVHGNLTVE 498
G L GSI ++G++ I I+ ++PQ DV+ LT
Sbjct: 81 GGLTHNGSIRYVLEDTGSEPNETEPKRAHLDGQDHPIQKHV-IMAYLPQQDVLSPRLTCR 139
Query: 499 ENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVG 558
E L F+A +L++ S+ K L+VE++IE LGL+ +++VG RG+SGG+++R+++G
Sbjct: 140 ETLKFAADLKLNS--SERTKKLMVEQLIEELGLKDCADTLVGDNSHRGLSGGEKRRLSIG 197
Query: 559 LEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALE-GVNICMVVHQPSYALFNMFDDL 617
+M+ PS++ LDEPT+GLD+ S+ L+++ L++ A E G M +HQP + + D +
Sbjct: 198 TQMISNPSIMFLDEPTTGLDAYSAFLVIKTLKKLAKEDGRTFIMSIHQPRSDILFLLDQV 257
Query: 618 ILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYIDI 659
+L KG +VY YF +G +VP+ +NP DY+ID+
Sbjct: 258 CILSKGN-VVYCDKMDNTIPYFESIGYHVPQLVNPADYFIDL 298
>ABG8_RAT (P58428) ATP-binding cassette, sub-family G, member 8
(Sterolin-2)
Length = 694
Score = 165 bits (418), Expect = 5e-40
Identities = 92/238 (38%), Positives = 144/238 (59%), Gaps = 2/238 (0%)
Query: 423 LRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGC-LVTGSILINGRNESIHSFKKI 481
+RN++ K++ G++ AI+G +G G+ T L + G+ G + +G I ING+ + +K
Sbjct: 110 IRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKC 169
Query: 482 IGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGT 541
+ V Q D + NLTV E L F AQ RL S+ ++ VE VI L L+ N+ VG
Sbjct: 170 VAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGN 229
Query: 542 VEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALEGVNICM 601
RGVSGG+R+RV++G++++ P +L+LDEPTSGLDS ++ L+R L R A + +
Sbjct: 230 TYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLI 289
Query: 602 VVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYIDI 659
+HQP +F +F DL+LL G +Y G A+ + +YF+ +G P NP D+Y+D+
Sbjct: 290 SLHQPRSDIFRLF-DLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDL 346
>WHIT_LUCCU (Q05360) White protein
Length = 677
Score = 164 bits (416), Expect = 8e-40
Identities = 88/245 (35%), Positives = 150/245 (60%), Gaps = 5/245 (2%)
Query: 420 KHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGK-ALGCLVTGSI--LINGRNESIH 476
KH+++NV G PG + A+MG SGAGKTT L+ALA + A G ++ S ++NG
Sbjct: 99 KHLIKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSARGVQISPSSVRMLNGHPVDAK 158
Query: 477 SFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRN 536
+ +V QDD+ G+LT E+L F A R+ +++ +K+ V++VI+ L L +N
Sbjct: 159 EMQARCAYVQQDDLFIGSLTAREHLIFQATVRMPRTMTQKQKLQRVDQVIQDLSLIKCQN 218
Query: 537 SVVGTVEK-RGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREALE 595
+++G + +G+SGG+RKR+ E + +P LL+ DEPTSGLDS + +++ L++ +
Sbjct: 219 TIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFMAASVVQVLKKLSQR 278
Query: 596 GVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDY 655
G + + +HQPS LF +FD ++L+ + G + + G+ + ++FS +G P NP D+
Sbjct: 279 GKTVILTIHQPSSELFELFDKILLMAE-GRVAFLGTPVEAVDFFSFIGAQCPTNYNPADF 337
Query: 656 YIDIL 660
Y+ +L
Sbjct: 338 YVQVL 342
>CDR2_CANAL (P78595) Multidrug resistance protein CDR2
Length = 1499
Score = 164 bits (416), Expect = 8e-40
Identities = 111/289 (38%), Positives = 167/289 (57%), Gaps = 16/289 (5%)
Query: 408 FRDLT--LTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKAL-GCLVTG 464
+RDLT + +K +++ IL +V G +KPG+ITA+MG SGAGKTT L+ L+ + G + G
Sbjct: 859 WRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDG 918
Query: 465 SILINGRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVER 524
L+NG SF++ IG+V Q DV TV E L FSA R S +SK EK V+
Sbjct: 919 ERLVNGHALD-SSFQRSIGYVQQQDVHLETTTVREALQFSAYLRQSNKISKKEKDDYVDY 977
Query: 525 VIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQ 583
VI+ L + +++VG V G++ QRKR+ +G+E+V +P LL+ LDEPTSGLDS ++
Sbjct: 978 VIDLLEMTDYADALVG-VAGEGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAW 1036
Query: 584 LLLRALRREALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYF 639
+ + +R+ A G I +HQPS + FD L+ L KGG Y G + + + YF
Sbjct: 1037 SICKLMRKLADHGQAILCTIHQPSALIMAEFDKLLFLQKGGRTAYFGELGENCQTMINYF 1096
Query: 640 SGLGIN-VPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEY 687
G + P+ NP ++ + ++ AAPG + Y ++ W +EY
Sbjct: 1097 EKYGADPCPKEANPAEWMLQVVG--AAPGSHAKQDYFEV---WRNSSEY 1140
Score = 98.6 bits (244), Expect = 7e-20
Identities = 131/562 (23%), Positives = 235/562 (41%), Gaps = 69/562 (12%)
Query: 422 ILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNESIHSFKKI 481
IL+++ ++PG +T ++G GAG +T L +A G + I S H ++
Sbjct: 167 ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 226
Query: 482 ----IGFVPQDDVVHGNLTVEENLWFSAQCRL------SADLSKPEKVLVVERVIEFLGL 531
+ + + DV +L+V + L F+A+ R D K + + + GL
Sbjct: 227 YRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATY-GL 285
Query: 532 QSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRR 591
RN+ VG RGVSGG+RKRV++ + ++ D T GLDSA++ +RAL+
Sbjct: 286 SHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKT 345
Query: 592 EA-LEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERI 650
A + + ++Q S + +FD++++L + G ++ G A K +EYF +G P+R
Sbjct: 346 SATILDTTPLIAIYQCSQDAYELFDNVVVLYE-GYQIFFGKASKAKEYFENMGWKCPQRQ 404
Query: 651 NPPDYYIDI---LEGIAAPGGSSGL--SYQDLPVKWMLHNEYPIPLDMRQHAAQFGIPQS 705
D+ + E PG + + Q+ W EY ++ + ++ +
Sbjct: 405 TTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETFWKNSPEY---AELTKEIDEYFV--- 458
Query: 706 VNSANDLGEVGKTFAGELWNDVRSNVELRGEKIRLNFLKSKDLSNRKTPGVFKQYKYFLI 765
E ++ GE + + S+V + R S+ T F Q +Y +
Sbjct: 459 --------ECERSNTGETYRE--SHVGKQSNNTR--------PSSPYTVSFFMQVRYVIA 500
Query: 766 RVGKQRLREARIQAVDYLILLLAGACLGSI---TKSSDQTF----GASGYTYTVIAVSLL 818
R + + I + L L+ G L S+ + S TF GA ++ A S L
Sbjct: 501 RNFLRMKGDPSIPLISILSQLVMGLILASVFFNLRKSTDTFYFRGGALFFSVLFNAFSSL 560
Query: 819 CKIAALRSFS--LDKLHYWRESDSGMSSLAYFLSKDTMDHFNTVIKPVVYLSMFYFLTNP 876
+I +L ++K + +LA +S+ + T+ +VY YF+ N
Sbjct: 561 LEILSLYEARPIVEKHRKYALYRPSADALASIISELPVKLLMTMSFNIVY----YFMVNL 616
Query: 877 RSTFTDNYIVLLCLVYCVTGIAYALSIVFEPGAAQLWSVLLPVVSTLIATQQKDSKILKA 936
R T + + L C +++ + GA V+T IAT S +
Sbjct: 617 RRTAGNFFFYWLMCASCTLVMSHMFRSI---GA----------VTTTIATAMSLSTVF-L 662
Query: 937 IANLCYSKWALQALVIANAERY 958
+A + Y+ + L I R+
Sbjct: 663 LAMIIYAGFVLPIPYILGWSRW 684
>CDR3_CANAL (O42690) Opaque-specific ABC transporter CDR3
Length = 1501
Score = 164 bits (414), Expect = 1e-39
Identities = 116/317 (36%), Positives = 182/317 (56%), Gaps = 19/317 (5%)
Query: 372 EKEKAQQQENKNLTFSGVLKMATNT-EKSKRPFIEIS----FRDLTLT--LKAQNKHILR 424
E E+A L FSG +++ + + R ++ S +R+LT T +K++ + IL
Sbjct: 801 EDEEAYMDGMAPLDFSGSTEISDYSYDYMDRKLLDTSNIFHWRNLTYTVKIKSEERVILN 860
Query: 425 NVTGKIKPGRITAIMGPSGAGKTTFLSALAGK-ALGCLVTGSILINGRNESIHSFKKIIG 483
N+ G +KPG +TA+MG SGAGKTT L+AL+ + G + +G+ ++NG E SF++ IG
Sbjct: 861 NIDGWVKPGEVTALMGASGAGKTTLLNALSERLTTGVITSGTRMVNG-GELDSSFQRSIG 919
Query: 484 FVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVERVIEFLGLQSVRNSVVGTVE 543
+V Q D+ TV E L FSA+ R +S EK VE++I+ L +++ +++VG V
Sbjct: 920 YVQQQDLHLETSTVREALKFSARLRQPNSVSIAEKDSYVEKIIDLLEMRTYVDAIVG-VP 978
Query: 544 KRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQLLLRALRREALEGVNICMV 602
G++ QRKR+ + +E+V P LL+ LDEPTSGLDS ++ + + +R+ A G I
Sbjct: 979 GEGLNVEQRKRLTIAVELVARPKLLVFLDEPTSGLDSQTAWSICKLIRKLANHGQAILCT 1038
Query: 603 VHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYFSGLGIN-VPERINPPDYYI 657
+HQPS L FD L+LL KG VY G + + EYF G + P+ NP ++ +
Sbjct: 1039 IHQPSAILLEEFDRLLLLQKGE-TVYFGEFGANCHTLIEYFERNGASKCPQHANPAEWML 1097
Query: 658 DILEGIAAPGGSSGLSY 674
++ AAPG + Y
Sbjct: 1098 GVIG--AAPGTQANQDY 1112
Score = 102 bits (255), Expect = 4e-21
Identities = 84/306 (27%), Positives = 152/306 (49%), Gaps = 27/306 (8%)
Query: 376 AQQQENKNLTFSGVLKMATNT-EKSKRPFIEISFRDLTLTLKAQNKHILRNVTGKIKPGR 434
A + + + +GVLK A N K ++ + SF IL+ + G IKPG
Sbjct: 125 AIESDYQTTVSNGVLKYARNIFNKFRKDNDDYSF------------DILKPMEGLIKPGE 172
Query: 435 ITAIMGPSGAGKTTFLSALAGKALGCLVTGSILIN----GRNESIHSFKKIIGFVPQDDV 490
+T ++G GAG +TFL +A + G V +I+ ++E + + + + + +
Sbjct: 173 VTVVLGRPGAGCSTFLKTIACRTEGFHVADGSVISYDGITQDEIRNHLRGEVVYCAETET 232
Query: 491 VHGNLTVEENLWFSAQCRLSAD----LSKPEKVL-VVERVIEFLGLQSVRNSVVGTVEKR 545
NLTV E L F+A + + +S+ E VV+ V+ GL +N+ VG R
Sbjct: 233 HFPNLTVGETLEFAALMKTPQNRPMGVSREEYAKHVVDVVMATYGLSHTKNTKVGNDFIR 292
Query: 546 GVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRREA-LEGVNICMVVH 604
G+SGG+RKR+++ +++ S+ D T GLD+A++ + +L+ A + + ++
Sbjct: 293 GISGGERKRLSIAEVTLVQASIQCWDNSTRGLDAATALEFISSLKTSASILNDTPLIAIY 352
Query: 605 QPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERINPPDYYIDI---LE 661
Q S +++FD +I++ + G ++ GS+++ YF +G +R PD+ I E
Sbjct: 353 QCSQNAYDLFDKVIVMYE-GYQIFFGSSQRAAAYFKKMGFVCQDRQTTPDFLTSITSPAE 411
Query: 662 GIAAPG 667
I PG
Sbjct: 412 RIIKPG 417
>CDR1_CANAL (P43071) Multidrug resistance protein CDR1
Length = 1501
Score = 164 bits (414), Expect = 1e-39
Identities = 111/289 (38%), Positives = 167/289 (57%), Gaps = 16/289 (5%)
Query: 408 FRDLT--LTLKAQNKHILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKAL-GCLVTG 464
+RDLT + +K +++ IL +V G +KPG+ITA+MG SGAGKTT L+ L+ + G + G
Sbjct: 861 WRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDG 920
Query: 465 SILINGRNESIHSFKKIIGFVPQDDVVHGNLTVEENLWFSAQCRLSADLSKPEKVLVVER 524
L+NG SF++ IG+V Q DV TV E L FSA R S +SK EK V+
Sbjct: 921 ERLVNGHALD-SSFQRSIGYVQQQDVHLPTSTVREALQFSAYLRQSNKISKKEKDDYVDY 979
Query: 525 VIEFLGLQSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLM-LDEPTSGLDSASSQ 583
VI+ L + +++VG V G++ QRKR+ +G+E+V +P LL+ LDEPTSGLDS ++
Sbjct: 980 VIDLLEMTDYADALVG-VAGEGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAW 1038
Query: 584 LLLRALRREALEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHG----SAKKVEEYF 639
+ + +R+ A G I +HQPS + FD L+ L KGG Y G + + + YF
Sbjct: 1039 SICKLMRKLADHGQAILCTIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYF 1098
Query: 640 SGLGIN-VPERINPPDYYIDILEGIAAPGGSSGLSYQDLPVKWMLHNEY 687
G + P+ NP ++ + ++ AAPG + Y ++ W +EY
Sbjct: 1099 EKYGADPCPKEANPAEWMLQVVG--AAPGSHAKQDYFEV---WRNSSEY 1142
Score = 93.2 bits (230), Expect = 3e-18
Identities = 69/245 (28%), Positives = 121/245 (49%), Gaps = 13/245 (5%)
Query: 422 ILRNVTGKIKPGRITAIMGPSGAGKTTFLSALAGKALGCLVTGSILINGRNESIHSFKKI 481
IL+++ ++PG +T ++G GAG +T L +A G + I S H ++
Sbjct: 169 ILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERH 228
Query: 482 ----IGFVPQDDVVHGNLTVEENLWFSAQCRL------SADLSKPEKVLVVERVIEFLGL 531
+ + + DV +L+V + L F+A+ R D K + + + GL
Sbjct: 229 YRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATY-GL 287
Query: 532 QSVRNSVVGTVEKRGVSGGQRKRVNVGLEMVMEPSLLMLDEPTSGLDSASSQLLLRALRR 591
RN+ VG RGVSGG+RKRV++ + ++ D T GLDSA++ +RAL+
Sbjct: 288 SHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKT 347
Query: 592 EA-LEGVNICMVVHQPSYALFNMFDDLILLGKGGLMVYHGSAKKVEEYFSGLGINVPERI 650
A + + ++Q S +++FD +++L + G ++ G A K +EYF +G P+R
Sbjct: 348 SAVILDTTPLIAIYQCSQDAYDLFDKVVVLYE-GYQIFFGKATKAKEYFEKMGWKCPQRQ 406
Query: 651 NPPDY 655
D+
Sbjct: 407 TTADF 411
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.326 0.138 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 112,429,165
Number of Sequences: 164201
Number of extensions: 4667100
Number of successful extensions: 21241
Number of sequences better than 10.0: 1016
Number of HSP's better than 10.0 without gapping: 856
Number of HSP's successfully gapped in prelim test: 160
Number of HSP's that attempted gapping in prelim test: 18662
Number of HSP's gapped (non-prelim): 1685
length of query: 1007
length of database: 59,974,054
effective HSP length: 120
effective length of query: 887
effective length of database: 40,269,934
effective search space: 35719431458
effective search space used: 35719431458
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 71 (32.0 bits)
Medicago: description of AC144720.7